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My academic journey began with a Bachelor of Science in Biochemistry, completed in June 2021 at the School of Sciences, University of Minho. I further pursued a Master of Science in Molecular Genetics, graduating in December 2023 from the same institution, and later expanded my knowledge through a Postgraduate Program in Bioinformatics at the Department of Informatics in 2025. Driven by a passion for research, I am currently a researcher at NOVA Medical School Research, contributing to the Pep-SICO project, which aims to develop peptide-based compartments capable of detecting and distinguishing phosphorylated aggregates of Tau 3R and 4R isoforms in biofluids — providing an innovative and accurate diagnostic tool for non-Alzheimer tauopathies. Beyond academics, I have organized several scientific events and actively participated in others. My areas of expertise include bioinformatics, molecular biology, biochemistry, human genetics, and neuroscience, allowing me to approach scientific challenges from a multidisciplinary perspective.
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Identification

Personal identification

Full name
Beatriz Barros dos Santos

Citation names

  • B. Barros-Santos

Author identifiers

Ciência ID
4A11-4128-404D
ORCID iD
0000-0002-5056-1629

Email addresses

  • beatriz.barros@nms.unl.pt (Professional)

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Korean Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2023/09 - 2025/10/31
Concluded
 Bioinformatics (Pós-Graduação)
Universidade do Minho Departamento de Informática, Portugal
 15
2024/04/08 - 2025/01/04
Concluded
 Scientific research skills course (Outros)
Universidade do Minho Escola de Medicina, Portugal
 19
2021/09 - 2023/12/11
Concluded
 Molecular Genetics (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"The unique biology of RNA-protein granules in brain pathologies" (THESIS/DISSERTATION)
 18
2023/04/17 - 2023/04/21
Concluded
 Proteomics Approaches in Life Sciencies (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 19
2022/11/14 - 2022/11/25
Concluded
 Laboratory Animal Science (Outros)
Universidade do Minho Escola de Medicina, Portugal
2018/09 - 2021/06
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Optimization of the encapsulation of Candida albicans proteins in DODAB:MO liposomes by the incubation method" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2025/11/04 - Current Researcher (Research) Universidade Nova de Lisboa Medical School, Portugal
2024/04/08 - 2025/07/04 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2024/01/02 - 2024/04/05 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2025/03/20 - 2025/06/25 Challenging current models of valence encoding in the mammalian brain – VALENCE
101003187
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 European Research Council
Ongoing
2024/04/08 - 2024/12/08 Detection of AD markers in blood samples
2022.04850.PTDC
Research Fellow
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. B. Barros-Santos; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Papadimitriou, Georgia; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Silva, JM. "Therapeutic potential of mTOR inhibitor - Torisel – for the clearance of Tau accumulation and RNA-protein granules in stress and Alzheimer’s Disease pathologies". Paper presented in XIX Meeting of the Portuguese Society for Neuroscience, 2025, 2025.
  2. Nóbrega-Martins, Rita; Cunha, Adriana; Guedes, Sofia; B. Barros-Santos; Campos-Marques, Carlos; Papadimitriou, Georgia; Maciel, Patrícia; et al. Corresponding author: Joana Margarida Silva. "The therapeutic potential of TUDCA in stress-related brain pathologies". Paper presented in XIX Meeting of the Portuguese Society for Neuroscience, 2025.
  3. B. Barros-Santos; Papadimitriou, Georgia; Campos-Marques, Carlos; Nóbrega-Martins, Rita; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. Corresponding author: Joana Margarida Silva. "Therapeutic potential of mTOR inhibitor – Torisel - against stress and Alzheimer’s Disease pathologies". Paper presented in 3rd Symposium on Alzheimer's Disease, 2025.
  4. Nóbrega-Martins, Rita; Cunha, Adriana; Guedes, Sofia; B. Barros-Santos; Campos-Marques, Carlos; Papadimitriou, Georgia; Maciel, Patrícia; Duarte-Silva, S; Joana Margarida Silva. Corresponding author: Joana Margarida Silva. "The therapeutic potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2025, 2025.
  5. B. Barros-Santos; Guedes, Sofia; Papadimitriou, Georgia; Campos-Marques, Carlos; Martina Samiotaki; Sotiropoulos, Ioannis; Silva, JM. Corresponding author: Silva, JM. "Sentinels of synaptic function: exploring RNA-binding proteins in Down syndrome synaptic degeneration". Paper presented in ICVS Retreat, 2025.
  6. B. Barros-Santos; Papadimitriou, Georgia; Gens, Matilde Sofia Antunes; Wolozin, Benjamin; Sotiropoulos, Ioannis; Silva, JM. Corresponding author: Silva, JM. "Therapeutic potential of mTOR inhibitor – Torisel - against stress and Alzheimer’s Disease pathologies". Paper presented in XIX Meeting of the Portuguese Society for Neuroscience, 2025, 2025.
  7. B. Barros-Santos; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Papadimitriou, Georgia; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. Corresponding author: B. Barros-Santos. "Therapeutic potential of mTOR inhibitor – Torisel - against stress and Alzheimer’s Disease pathologies". Paper presented in ERA Chairs annual meeting IMMUNOHUB & NCBIO, 2024.
  8. B. Barros-Santos; Gerontidi, Dimitra ; Papadimitriou, Georgia; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. "Therapeutic potential of mTOR inhibitor for the clearance of Tau accumulation and RNA-protein granules in stress and Alzheimer’s Disease pathologies". Paper presented in ICVS Retreat 2024, 2024.
  9. Anastasia Megalokonomou; Campos-Marques, Carlos; B. Barros-Santos; Papadimitriou, Zeta; Vamvaka Iakovou, Anastasia; Godinho, Bruno; Watts, Jonathan K; et al. Corresponding author: Anastasia Megalokonomou. "Antisense Oligonucleotides as a novel RNA-targeted therapeutic approach against Tau-driven neuronal malfunction". Paper presented in EPHAR - Federation of European Pharmacological Societies 2024, 2024.
  10. Megalokonomou A.; Campos-Marques C.; Godinho B.; Watts J.; Samiotaki M.; Panayotou G.; Papadimitriou G.; et al. "A novel RNA-targeted therapeutic approach against Tau-driven neuronal pathology in Alzheimer's disease brain pathology.". Paper presented in 73rd National Conference of Hellenic Society of Biochemistry and Molecular Biology (HSBMB), Athens, Greece, 2023.
  11. Megalokonomou A.; Campos-Marques C.; Godinho B.; Watts J.; Samiotaki M.; Panayotou G.; Papadimitriou G.; et al. "A novel RNA-targeted therapeutic approach against Tau-driven neuronal pathology in Alzheimer's disease brain pathology.". Paper presented in 10th Young Scientists Day of National Conference of Hellenic Society of Biochemistry and Molecular Biology (HSBMB), Athens, Greece, 2023.
  12. Papadimitriou G; Campos-Marques C; B. Barros-Santos; Gomes P; Dioli C; Wolozin B; Silva JM; Sotiropoulos I. Corresponding author: Papadimitriou G. "Dissecting the molecular interplay between Tau & RNA-binding proteins in stress-driven brain pathology". Paper presented in 30th Meeting of the Hellenic Society for Neuroscience (HSfN), Athens, Greece, 2023.
  13. Nóbrega-Martins, Rita; Guedes, Sofia; Udochukwu, Lucian; B. Barros-Santos; Campos-Marques, Carlos; Silva, Iara; Maciel, Patrícia. "Therapeutical potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in ISN-ESN 2023 Meeting, 2023, 2023.
Journal article
  1. Maria jose Lagartos-Donate; Guang Lu; Xurui Jin; Shi-qi Zhang; Jun-ping Pan; Shu-Qin Cao; Jon Storm-Mathisen; et al. "NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C". Science Advances (2025): https://www.science.org/doi/10.1126/sciadv.ady9811.
    10.1126/sciadv.ady9811
  2. Rita Nóbrega-Martins; Beatriz Barros-Santos; Georgia Papadimitriou; Ioannis Sotiropoulos; Benjamin Wolozin; Joana Margarida Silva. "RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration". Journal of Neurochemistry (2025): https://doi.org/10.1111/jnc.70269.
    10.1111/jnc.70269
  3. Beatriz Barros-Santos; Carlos Campos-Marques; Andreia Filipa Salvador; Joana Margarida Silva. "Integration of omics to explore novel disease pathways in Down syndrome neurodegeneration – focusing on integrated stress response". Brain Organoid and Systems Neuroscience Journal (2025): https://doi.org/10.1016/j.bosn.2025.04.006.
    10.1016/j.bosn.2025.04.006
  4. Campos-Marques, Carlos; Anastasia Megalokonomou; B. Barros-Santos; Godinho, Bruno; Soares-Cunha, Carina; Lee, Jonathan; Wagh, Atish A; et al. "Screening of novel ASOs against Tau protein - shifting isoforms". Molecular Therapy (2025):
    Submitted
  5. Campos-Marques, Carlos; B. Barros-Santos; Sotiropoulos, Ioannis; Silva, JM. "Brain plasticity and behavioral deficits in Down syndrome: "space" for therapeutic intervention?". (2025):
    Submitted
  6. Megalokonomou, A.; Campos-Marques, C.; Dinopoulos, M.; Godinho, B.; Watts, J.; Papadimitriou, G.; Vamvaka-Iakovou, A.; et al. "Antisense oligonucleotides as a novel therapeutic approach in Tau-related brain pathology". Neuroscience Applied 4 (2025): 105504. https://doi.org/10.1016/j.nsa.2025.105504.
    Published • 10.1016/j.nsa.2025.105504
Thesis / Dissertation
  1. "The unique biology of RNA protein granules in brain pathologies". Master, Universidade do Minho Escola de Ciências, 2024.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/10/12 - 2025/03/28 Bioinformatics Open Days (XIV Edition) (2025/03/26 - 2025/03/28)
Conference (President of the Organising Committee)
 Universidade do Minho Escola de Engenharia, Portugal
2024/02/15 - 2024/03/16 Bioinformatics Open Days (XIII Edition) (2024/03/14 - 2024/03/16)
Conference (Member of the Organising Committee)
 Universidade do Minho Escola de Engenharia, Portugal
2024/03/12 - 2024/03/12 Brain awareness week (2024/03/11 - 2024/03/17)
Festival (Co-organisor)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/09/29 - 2023/09/29 The European Researchers' Night is a Europe-wide public event, which displays the diversity of science and its impact on citizens' daily lives in fun, inspiring ways. (2023/09/29 - 2023/09/29)
2023/03/15 - 2023/03/15 Brain awareness week (2023/03/13 - 2023/03/19)
Festival (Co-organisor)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/02/06 - 2025/02/07 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Symposium
 3rd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2024/12/05 - 2024/12/06 ERA Chairs annual meeting IMMUNOHUB & NCBIO, 2024
Meeting
 ERA Chairs annual meeting IMMUNOHUB & NCBIO, 2024
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/03/16 - 2024/03/16 Introduction to Computational Protein Design Tools
Workshop
 Bioinformatics Open Days (XIII Edition)
Universidade do Minho Escola de Engenharia, Portugal
2021/12/15 - 2023/06/27 EIPODs inspire (18 months’ mentorship from an EMBL Interdisciplinary Postdoc to expand the scientific network and explore cutting-edge life science research)
Other
 EIPODs inspire
EMBL Heidelberg Genomics Core Facility, Germany
2023/02/11 - 2023/02/11 Nanoparticle Production and Characterization for Biomedical Applications
Workshop
 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2023/02/10 - 2023/02/11 Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Symposium
 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
Universidade do Porto Faculdade de Engenharia, Portugal
2021/12/16 - 2021/12/17 23rd EMBL PhD Symposium: The Big Picture: Zooming into Life
Symposium
 23rd EMBL PhD Symposium: The Big Picture: Zooming into Life
EMBL Heidelberg Genomics Core Facility, Germany
2021/03 - 2021/03 Nanoparticle Production and Characterization for Biomedical Applications
Workshop
 Jornadas da Ciência
Universidade do Porto, Portugal
2020/03 - 2020/03 Data Analysis
Workshop
 Jornadas da Ciência
Universidade do Minho Escola de Ciências, Portugal
2019/03 - 2019/03 An hour of python
Workshop
 Jornadas da Ciência
Universidade do Minho Escola de Ciências, Portugal
2019/03 - 2019/03 Animal experimentation – what can we do? How can we do it? And how do we feel about it?
Workshop
 Jornadas da Ciência
Universidade do Minho Escola de Ciências, Portugal

Association member

Society Organization name Role
2025/01 - Current Portuguese Society of Neurosciences Member
2023/01 - Current International Society for Neurochemistry Member

Committee member

Activity description
Role 		Institution / Organization
2021/12 - 2023/06 Journal UMinho Science (JUS)
President / Vice-president
 Universidade do Minho, Portugal

Mentoring / Tutoring

Topic Student name
2024/03/01 - Current Sentinels of synaptic function: exploring RNA-binding proteins in Down syndrome synaptic degeneration Sofia Gonçalves
2023/03/01 - 2025/10/31 Autophagy as a regulator of synaptic function in a model of Tau pathology Matilde Antunes