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Ana Sofia Fonseca Ramos holds a degree in Biotechnology Engineering (2003), an MSc in Biotechnology Engineering (2011), and a PhD in Health Sciences (2025). She has completed multiple hands-on training programs in bioinformatics and computational biology, including pharmaceutical bioinformatics, artificial intelligence in drug discovery, next-generation sequencing (NGS) analysis, bulk RNA-seq, network and pathway analysis, and metagenomics (Qiime2). With a strong background in cancer research and bioinformatics, Ana Sofia has published three articles in peer-reviewed international journals, presented at 11 scientific events, and supervised two undergraduate theses, co-supervised three BSc projects, and one MSc thesis. Since 2021, she has been an Assistant Professor at Universidade Lusófona, where she teaches Human Genetics, Immunology, and Bioinformatics. Her research focuses on identifying diagnostic and prognostic biomarkers in cancer, investigating tumor microenvironment progression-related mechanisms, and discovering novel inhibitors. More recently, she has expanded her interests to inflammatory mechanisms and their role in disease progression.
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Identification

Personal identification

Full name
Ana Sofia Fonseca Ramos

Citation names

  • Ramos, Sofia
  • Ramos, A. S.

Author identifiers

Ciência ID
4912-EC14-A39A
ORCID iD
0000-0001-5846-6194
Scopus Author Id
58327366700

Email addresses

  • sofia.ramos@ulusofona.pt (Professional)

Telephones

Mobile phone
  • 912635765 (Personal)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
French Elementary (A2) Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2025/01/12 - 2025/02/09
Concluded
 NGS - Sequence to insights (Outros)
Decode Life Bioinformatics training institute, India
2024/12/01 - 2024/12/31
Concluded
 Cancer Genomics (Outros)
Decode Life Bioinformatics training institute, India
2024/12/11 - 2024/12/18
Concluded
 Mini-course - Metagenomics: from basics to applications (Outros)
NyberMan, Netherlands
2023/11/01 - 2023/11/30
Concluded
 Drug discovery and Development (Outros)
Decode Life Bioinformatics training institute, India
2023/09/01 - 2023/09/30
Concluded
 Genomes, Networks and Pathways (Outros)
Decode Life Bioinformatics training institute, India
2018/11/26 - 2023/09/30
Ongoing
 Health Sciences (Doktor (PhD))
Major in Biomedicine
Universidad de Alcalá, Spain
2023/07/10 - 2023/08/02
Concluded
 Workshop on RNASeq data analysis using R (Outros)
GeneSpectrum Life Sciences, India
2023/06/05 - 2023/07/04
Concluded
 DMSL Python (Outros)
Decode Life Bioinformatics training institute, India
2023/05/22 - 2023/05/26
Concluded
 Molecular Bioinformatics Online Practical Course (Outros)
Major in Bioinformatica Molecular
Universidade do Porto Faculdade de Medicina, Portugal
2023/04/21 - 2023/05/15
Concluded
 Epigenetics - Human Health (Outros)
Major in Genetics
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/04/05 - 2023/04/20
Concluded
 Epigenetics - Foundations (Outros)
Major in Genetics
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/06 - 2023/04/10
Concluded
 MOOC Machine Learning y Big Data para la Bioinformática (Diplôme d´études supérieures)
Major in Machine learning and Bioinformatics
Universidad de Granada, Spain
2023/01/16 - 2023/03/22
Concluded
 Artificial Intelligence in Drug Discovery (Outros)
Major in Pharmaceutical Bioinformatics
Uppsala Universitet, Sweden
2023/01/15 - 2023/03/03
Concluded
 The 7th Evidence-Based Research Training School (Outros)
Major in Evidence-based Research in Clinical Health Research
Høgskulen på Vestlandet, Norway
2022/11/21 - 2023/01/06
Concluded
 Applied Pharmaceutical Bioinformatics (Outros)
Major in Pharmaceutical Bioinformatics
Uppsala Universitet, Sweden
2022/08/29 - 2022/10/30
Concluded
 Pharmaceutical Bionformatics (Outros)
Major in Pharmaceutical Bioinformatics
Uppsala Universitet, Sweden
2022/08/29 - 2022/10/13
Concluded
 Applied Pharmaceutical Structural Bioinformatics (Outros)
Major in Pharmaceutical Bioinformatics
Uppsala Universitet, Sweden
2022/07/22 - 2022/08/18
Concluded
 Next Generation Sequencing Analysis (Outros)
Major in Bioinformatics applied to Genetics
Decode Life Bioinformatics training institute, India
2022/04/30 - 2022/07/16
Concluded
 Data Science com Python (DESE)
Major in Data Science
Universidade Lusófona, Portugal
2020/03/11 - 2020/05/31
Concluded
 Training in Clinical Trial Monitoring (Outros)
CBIOS, the Research Center for Biosciences & Health Technologies, Portugal
 14
2015/03/18 - 2016/02/28
Concluded
 MBA em Gestão de Empresas (Pós-Graduação)
Institute of Business Management, Portugal
 17
2009/11/02 - 2011/11/07
Concluded
 Biotechnology Engineering (Mestrado)
Major in Biotechnology applied to health
Universidade Lusófona, Portugal
"Allogenic Transplantation of Hematopoietic Progenitors - Study of Factors Associated with Graft versus Host Disease in Portuguese context " (THESIS/DISSERTATION)
 14
1998/10/11 - 2003/12/31
Concluded
 Biotechnology engineering (Licenciatura)
Universidade Lusófona, Portugal
"Effect of Daclizumab in preventing graft-versus-host disease through selective depletion of alloreactive cells" (THESIS/DISSERTATION)
 15
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/01 - Current Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2021/09/01 - 2022/07/31 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal

Other Careers

Category
Host institution 		Employer
2004/05/14 - 2004/08/27 Assistente (Técnico Superior de Saúde - Laboratório) Instituto Clínico e Imunológico de Lisboa, Portugal
Projects

Contract

Designation Funders
2020/11/16 - Current Lusophone flora fighting disease: focus on therapeutic lysyl oxidase modulators
ILIND/F+/EI/01/2020
PhD student
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. Ferreira, Sandra; Ramos, Sofia; Santos, Beatriz; Nascimento, Carlota; Santos, Mariana; Diaz-Lanza Ana María; Rijo, Patricia; et al. "LusoModLox: in search of therapeutic lysyl oxidase inhibitors". Paper presented in CBIOS Conference, Lisbon, 2023.
    Published • https://doi:10.19277/bbr.20.2.320
  2. Ferreira, Sandra; Ramos, Sofia; Holota, Serhii; Khyluk, Dmytro; Lesyk, Roman; Finyuk, Natalia; Santos, Daniel; Nuno Saraiva; Fernandes, Ana Sofia. Corresponding author: Fernandes, Ana Sofia. "A Novel Lysyl Oxidase Like 2 Inhibitor decreases Breast Cancer cells migration". Paper presented in 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology, Coimbra, 2023.
    Published
  3. Ramos, Sofia; Gregório, João; Fernandes, Ana Sofia; Saraiva, Nuno. "Synchronized expression dysregulation of Redox and Calcium-related genes: implications for breast cancer patient survival.". Paper presented in 5th CBIOS conference, Lisbon, 2023.
    Published
  4. Ramos, Sofia; Fernandes, Ana Sofia; Saraiva, Nuno. "Simultaneous expression dysregulation of redox and calcium signalling-related genes: impact on breast cancer patient survival". Paper presented in FEBS, Lisbon, 2022.
    Published
  5. Ferreira, Sandra; Ramos, Sofia; Holota, Serhii; Khyluk, Dmytro; Lesyk, Roman; Saraiva, Nuno; Fernandes, Ana Sofia. "Lysyl oxidase like 2 as a therapeutic target for breast cancer: bioinformatics analysis and biochemical evaluation of 4-thiazolidinone derivatives". Paper presented in FEBS, Lisbon, 2022.
    Published
  6. Ramos, Sofia; Ferreira, Sandra; Fernandes, Ana Sofia; Garcia Saraiva, Nuno. "Lysyl Oxidases in the pathophysiology of breast cancer: a bioinformatics approach.". Paper presented in Biomed Biopharm Res, 2021.
    Published
  7. Ramos, Sofia; Ferreira, Sandra; Nuno Saraiva; Fernandes, Ana Sofia. Corresponding author: Ramos, Sofia. "Bioinformatics analysis for Lysyl Oxidases as therapeutic targets for breast cancer". Paper presented in Molecular Analysis for Precision Oncology Congress 2021, 2021.
    Published
Conference poster
  1. Ramos, Sofia; Gregório, João; Fernandes, Ana Sofia; Saraiva, Nuno. "Coordinated Expression of Genes Related to Redox status and Ca2+ homeostasis: Implications for Breast Cancer Patient Survival.". Paper presented in EACR Virtual Conference on Signaling Circuits in Cancer, 2024.
  2. Ramos, Sofia; Gregório, João; Fernandes, Ana Sofia; Nuno Saraiva. Corresponding author: Nuno Saraiva. "Crosstalk between Expression of Redox and Calcium Signaling Genes and Its Impact on Breast Cancer Patient Survival.RSGDREAM 2023". Paper presented in RECOMB/ISCB Conference on Regulatory & Systems Genomics with DREAM Challenges (RSGDREAM) 2023, 2023.
  3. Ferreira, Sandra; Ramos, Sofia; Diaz-Lanza Ana María; Fernandes, Ana Sofia; Nuno Saraiva; Rijo, Patricia; Brito Palma, Bernardo. Corresponding author: Fernandes, Ana Sofia. "Exploring the Multifaceted Potential of EPCU in Targeting Tumorigenesis and Hormone Regulation". Paper presented in 2nd Asian Council Symposium, 2023.
  4. Ramos, Sofia; Gregório, João; Ana Sofia Fernandes; Nuno Saraiva. Corresponding author: Nuno Saraiva. "The influence of Redox and Calcium signalling-related gene expression profiles on the progression of Breast Cancer". Paper presented in Encontro de Ciencia 2023, 2023.
  5. Ramos, Sofia; Ana Sofia Fernandes; Saraiva, Nuno. "Expression profile of cellular redox and calcium signalling-related genes: role in breast cancer progression.". Paper presented in The Biochemistry Global Summit, Lisbon 2022, 2022.
  6. Ferreira, Sandra; Ramos, Sofia; Holota, Serhii; Khyluk, Dmytro; Lesyk, Roman; Saraiva, Nuno; Fernandes, Ana Sofia. "Lysyl oxidase like 2 as a therapeutic target for breast cancer: bioinformatics analysis and biochemical evaluation of 4-thiazolidinone derivatives". Paper presented in The Biochemistry Global Summit, Lisbon 2022, 2022.
  7. Ferreira, Sandra; Ramos, Sofia; Serhii Holota; Dmytro Khyluk; Roman Lesyk; Nuno Saraiva; Ana Sofia Gregório Fernandes. Corresponding author: Ana Sofia Gregório Fernandes. "Targeting lysyl oxidases for breast cancertherapy: bioinformatic analysis and evaluationof 4-thiazolidinone derivatives as LOXL2inhibitors". Paper presented in The Biochemistry Global Summit, 25th IUBMB Congress, 46th FEBS Congress, 15th PABMB Congress, 2022.
  8. Alves, Bárbara; Calado, Rita; Rodrigues, João C.; Jorge, João; Abdul, Sházia; Guerreiro, Íris; Portela, Raquel; et al. Corresponding author: Nunes, Alexandra. "NiPharmins as efficacious prophylactic options to prevent Staphylococcal infections". Paper presented in 3rd INSA's Young Researcher Day, Lisbon, Portugal, 8 November, 2022.
  9. Ramos, Sofia; Santana, Miguel; Nunes, Alexandra. "Bioinformatic analysis of Claudin genes family as therapeutic targets for pancreatic adenocarcinoma". Paper presented in ISCB-Latin America SolBio BioNetMX Conference on Bioinformatics 2022, Juriquilla, Mexico, 3-7 November, 2022.
  10. Ferreira, Sandra; Ramos, Sofia; Saraiva, Nuno; Fernandes, Ana Sofia. "Lysyl Oxidases in the pathophysiology of breast cancer: a bioinformatics approach". Paper presented in 56º Congresso Anual da SBFIS Online, 2021.
  11. Ramos, Sofia; Ferreira, Sandra; Saraiva, Nuno; Fernandes, Ana Sofia. "Bioinformatics analysis for Lysyl Oxidases as therapeutic targets for breast cancer.". Paper presented in Molecular Analysis for Precision Oncology Virtual Congress 2021, 2021.
  12. Ramos, Sofia; Ferreira, Sandra; Saraiva, Nuno; Fernandes, Ana Sofia. "Lisil Oxidases como possíveis alvos terapêuticos para o cancro da mama: análise baseada na bioinformática.". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia. Congresso Híbrido., 2021.
  13. Sofia Ramos; Nuno Saraiva; Ana Sofia Fernandes. "Bioinformatic Databases as a tool to analyze alterations in Cell Physiology in Carcinogenesis: A comparative analysis of open access data analysis platforms.". Paper presented in Fisiologia ainda sob estresse em tempos da COVID-19, 2020.
Journal article
  1. Luz, Paulo; Ramos, Sofia; Oliveira, Maria José; Costa, João G.; Saraiva, Nuno; Fernandes, Ana S.. "Interaction between redox regulation, immune activation, and response to treatment in HER2+ breast cancer". Redox Biology 82 (2025): 103609. https://doi.org/10.1016/j.redox.2025.103609.
    Published • 10.1016/j.redox.2025.103609
  2. Ferreira, Sandra; Ramos, Sofia; Holota, Serhii; Khyluk, Dmytro; Lesyk, Roman; Finyuk, Natalia; dos Santos,Daniel JVA; et al. "Lysyl oxidase like 2: an enzyme at the crossroad of Toxicology and Pharmacology". Toxicology Letters 384 1 (2023): S92.
    Open access • Published
  3. Ramos, Sofia; Ferreira, Sandra; Fernandes, Ana S.; Saraiva, Nuno. "Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.883998.
    Open access • Published • 10.3389/fphar.2022.883998
  4. Ramos, Sofia; Fernandes, Ana Sofia; Saraiva, Nuno. "Gene expression and survival analysis in cancer research using online open access platforms: a comparative analysis". Biomedical and Biopharmaceutical Research Journal 17 2 (2020): 1-19. http://dx.doi.org/10.19277/bbr.17.2.247.
    10.19277/bbr.17.2.247

Other

Other output
  1. Human Genetics - Oncobiology (didactic material). 2022. Ramos, Sofia; Nunes, Alexandra.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10 Crosstalk between expression of redox and calcium-related genes and its potential to unveil new therapeutic targets for breast cancer. LIV Congresso da Sociedade Portuguesa de Farmacologia
(Lisbon, Portugal)
2023/11/10 Synchronized expression of Redox and Calcium-related genes. implications for breast cancer patient survival V Jornadas CBIOS
CBIOS, Universidade Lusofona (Lisbon, Portugal)
2023/10 Targeting Lysyl Oxidase Like 2 to prevent breast cancer metastases X Congresso Iberoamericano de Ciências Farmacêuticas
(Coimbra, Portugal)
2022/11/03 Online oral presentation of poster entitled "Bioinformatic analysis of Claudin family as therapeutic targets for pancreatic adenocarcinoma" 4th ISCB-Latin America SoIBio BioNetMX Conference on Bioinformatics 2022
ISCB-Latin America SoIBio BioNetMX (Juriquilla, Mexico)
2022/03/14 Presentation of preliminary results of doctoral project: Expression profile of cellular redox and calcium signalling-related genes: role in breast cancer progression Lab meeting, CBIOS
Universidade Lusófona (Lisbon, Portugal)
2020/10/02 Presenting poster "Bioinformatics databases as a tool to analyze alterations in cell phisiology in carcinogenesis: A Comparative analysis of open access data analysis platforms" 55º Congresso anual da SBFIS
Sociedade Brasileira de Fisiologia (online event) (São Paulo, Brazil)
2020/02/28 Presentation of Doctoral project: Expression profile of cellular redox and calcium signalling-related genes: role in breast cancer progression CBIOS Sessions
CBIOS - Universidade Lusófona (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Identifying novel druggable inhibitors for Chronic Obstructive Pulmonary Disease_ an in silico approach
Supervisor
Faculdade de Engenharia da Universidade Lusofona, Portugal
2024 - Current Identifying novel druggable inhibitors for Chronic Obstructive Pulmonary Disease_ an in silico approach
Co-supervisor
 Degree (Degree)
Faculdade de Engenharia da Universidade Lusofona, Portugal
2023 - Current Processos celulares associados a genes com expressão correlacionada com TMBIM1, 4 e 6 em amostras gliomas: análise bioinformática.
Co-supervisor
Escola de Ciências e Tecnologias da Saúde da Universidade Lusófona , Portugal
2024 - 2024 Protocolo otimizado para imagens 3D da embriogénese do peixe-zebra
Supervisor
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2024 - 2024 Development of a System for Locomotion Analysis in Zebrafish (Danio rerio) Using Artificial Intelligence
Co-supervisor
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2022/01/04 - 2022/07/12 Projeto de final de curso - Nph-1 como Opção Profilática Eficaz na Prevenção de Infeções Estafilocócicas
Co-supervisor
 Biologia (Degree)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2021/11/05 - 2022/06/15 Projeto de final de curso - Análise bioinformática de perfis de expressão génica das Claudinas em pacientes com adenocarcinoma pancreático
Co-supervisor
 Biologia (Degree)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/11/08 - Current Poster participation entitled "NiPharmins as efficacious prophylactic options to prevent Staphylococcal infections"
Meeting
 3o Dia do Jovem Investigador INSA 2022
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2022/09/20 - Current Participation in Virtual Ensembl Browser Workshop
Congress
 4th Congress in Women in Bioinformatics and Data Science Latin America
Women in Bioinformatics and Data Science Latin America, Argentina
2021/02/12 - Current Participation in specific formation "Effect of TMBIM family members in glioma"
Meeting
 CBIOS Sessions
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2024/02/13 - 2024/02/14 Coordinated Expression of Genes Related to Redox status and Ca2+ homeostasis: Implications for Breast Cancer Patient Survival
Conference
 Virtual Conference on Signaling Circuits in Cancer
European Association For Cancer Research, United Kingdom
2023/05/04 - 2023/05/05 Congress participation in the work intitled "Validação Portuguesa da Obsession with COVID-19 Scale (PT-OCS)"
Congress
 XI Congresso Iberoamericano de Avaliação Psicológica
Universidade do Algarve, Portugal
2021/03/12 - 2021/03/12 Participation in specific formation "Mechanisms of resistance to trastuzumab and pertuzumab in her2-positive breast cancer: preliminary analysis of redox and immune-related biomarker"
Meeting
 CBIOS Sessions
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2021/02/17 - 2021/02/18 Participation in virtual meeting "Advances in Redox Biology and Medicine: From Basic Mechanisms to Clinical Implications"
Congress
 "Advances in Redox Biology and Medicine: From Basic Mechanisms to Clinical Implications"
Israel Society for Oxygen and Free Radical Research, Israel
2020/11/23 - 2020/11/23 Presenting poster "Bioinformatic Databases as a tool in cancer research: a comparative analysis of gene expression and survival data platforms."
Meeting
 IV Jornadas CBIOS under the theme “There is research beyond COVID-19”
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2020/09/25 - 2020/09/25 Participation in virtual conference "Cancer Biology: From basic to translation research" Cancer Biology: From basic to translation research
Liga Portuguesa Contra o Cancro, Portugal
2019/10/02 - 2019/10/02 Participation in Cell Migration Workshop
Workshop
 Cell Migration Workshop
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2018/06/22 - 2018/06/22 Introduction to Meta-analysis
Congress
 Introduction to Meta-analysis, 3º Congresso Internacional do Centro de Investigação Interdisciplinar Egas Moniz
Centro de Investigação Interdisciplinar Egas Moniz, CiiEM, Research and Innovation in Human & Health Sciences, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/06 Estudo da estrutura da flavocitocromo c sulfureto desidrogenase de Thiocapsa roseopersicina
(Thesis) Arguer
 Margarida Carreira (Other)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2023 Desenvolvimento de novos veículos de administração de fármacos
(Thesis) Arguer
 Pedro Cruz (Other)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal

Association member

Society Organization name Role
2023/11/05 - 2025/11/05 EACR - The European Association for Cancer Research
2023/10/01 - 2025/10/01 ISCB - International Society for Computational Biology
Distinctions

Award

2025 B.INOV 2.0
Ordem dos Farmaceuticos, Portugal