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Ana Luísa Novo de Oliveira. Completed the Doutoramento in PhD in Biotechnology in 2013/11/18 by Universitat de Barcelona Departament de Fisicoquímica, Licenciatura in Biochemistry in 2008/09/22 by Universidade do Porto Faculdade de Ciências and Master in Molecular Biotechnology in 2010/09/10 by Universitat de Barcelona Departament de Fisicoquímica. Is Researcher in REQUIMTE LAQV Porto and Invited Assistant Professor in Universidade do Porto Departamento de Química e Bioquímica. Published 13 articles in journals. Participates and/or participated as Researcher in 4 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry and Exact Sciences with emphasis on Physical Sciences with emphasis on Chemical Physics. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: "Drug Discovery"; "Molecular Dynamics Simulations; "Computational Enzymology"; .
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Identification

Personal identification

Full name
Ana Luísa Novo de Oliveira

Citation names

  • Oliveira, Ana

Author identifiers

Ciência ID
481B-9131-FBE5
ORCID iD
0000-0001-6594-6022

Email addresses

  • anoliveira@fc.up.pt (Professional)

Addresses

  • Rua do Campo Alegre n. 1021, 4169-007 , Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Physical Sciences - Chemical Physics
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2013/11/18
Concluded
 PhD in Biotechnology (Doutoramento)
Universitat de Barcelona Departament de Fisicoquímica, Spain
 Excellent CumLaude
2010/09/10
Concluded
 Molecular Biotechnology (Master)
Universitat de Barcelona Departament de Fisicoquímica, Spain
2008/09/22
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2019/04/01 - Current Researcher (Research) REQUIMTE LAQV Porto, Portugal
2018/09/01 - 2019/03/31 Postdoc (Research) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2014/03/01 - 2018/08/31 Researcher (Research) Uppsala Universitet, Sweden
2009/09/01 - 2014/02/28 Research Assistant (Research) Universidad de Barcelona Facultad de Farmácia, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Departamento de Química e Bioquímica, Portugal
2012/09/01 - 2013/09/30 Associate Professor (University Teacher) Universidad de Barcelona Facultad de Farmácia, Spain
Projects

Grant

Designation Funders
2008/10 - 2012/03 Unraveling the molecular mechanism of nitrosative stress resistance in tuberculosis
grant.223335
PhD Student Fellow
European Commission
2009 - 2011 Bases del mecanismo molecular de resistencia a estrés nitrosativo en tuberculosis.
SAF2008-05595-C02-01
PhD Student Fellow
Ministerio de educación y ciencia
2009 - 2010 Mecanismo molecular de acción en la hemoglobina truncad N de M. tuberculosis. Implicaciones terapéuticas
PCI2006-A7-0688
PhD Student Fellow
Ministerio de educación y ciencia
Concluded

Contract

Designation Funders
2021/03/29 - 2024/03/28 Murderous Venom - Towards a Universal Antidote Against Snakebite
PTDC/QUI-OUT/1401/2020
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/29 - 2024/03/28 Murderous Venom - Towards a Universal Antidote Against Snakebite
PTDC/QUI-OUT/1401/2020
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/01 - 2018/12 Datorbaserade studier av biologisk katalys och molekylär igenkänning
grant.2014-03688_VR
Researcher
Vetenskapsradet
Concluded
2014 - 2018 Quantitative structural-based models for ligand interactions with G-protein coupled receptors
2014-2118
Researcher
Vetenskapsradet

Other

Designation Funders
2020/04/01 - Current Biodegrading Plastics
2019215204
Researcher
Universidade do Porto, Portugal
 Partnership for Advanced Computing In Europe
Ongoing
2019 - 2020 Enzyme instantaneous disorder as a key player in the catalytic power of enzymes
CHM151
Researcher
Oak Ridge National Laboratory
Ongoing
2019 - 2020 Local and collective motions as a gateway to the catalytic power of enzymes
CHM150
Researcher
Universidade do Porto, Portugal
 Oak Ridge National Laboratory
Ongoing
2018/10/02 - 2019/10/01 Bacterial Initiation factors and Termination factors as new targets to novel antibiotics
2018184467
Researcher
Universidade do Porto, Portugal
 Partnership for Advanced Computing In Europe
Concluded
2015 - 2016 Search for putative binding sites that can bind new antibiotics inhibiting the protein synthesis
SNAC
Integration into Research Grant Fellow
Uppsala universitet Institutionen för medicinsk cellbiologi, Sweden
 National Supercomputer Centre in Linkoping
Concluded
2014 - 2015 Protein synthesis release factors (RF1 and RF2) as targets for new antibiotics
SNIC 2014/1-241
Integration into Research Grant Fellow
Uppsala Universitet Institutionen för teknikvetenskaper, Sweden
 National Supercomputer Centre in Linkoping
Concluded
Outputs

Publications

Book chapter
  1. Oliveira, Ana. "Molecular simulations of globins: Exploring the relationship between structure, dynamics and function". In Recent Advances in Pharmaceutical Sciences, 2011, Chapter 6, 133-153. 2011.
    Published
Conference abstract
  1. Cristina Almeida; Ana Oliveira; Pedro Fernandes; Georgina Correia-da-Silva; Maria João Ramos; Tiago Augusto; Natércia Teixeira; Cristina Amaral. "A novel approach for ER<sup>+</sup> breast cancer treatment: A new compound that modulates aromatase and ER". 2019.
    10.3390/ecmc2019-06337
Journal article
  1. Ana Novo de Oliveira; Andreimar Martins Soares; Saulo Luís da Silva. "Peptides from Animal Venom and Poisons". International Journal of Peptide Research and Therapeutics 29 5 (2023): http://dx.doi.org/10.1007/s10989-023-10557-8.
    10.1007/s10989-023-10557-8
  2. Ana Novo de Oliveira; Andreimar Martins Soares; Saulo Luís Da Silva. "Why to Study Peptides from Venomous and Poisonous Animals?". International Journal of Peptide Research and Therapeutics (2023): https://doi.org/10.1007/s10989-023-10543-0.
    10.1007/s10989-023-10543-0
  3. Juliana Castro-Amorim; Ana Oliveira; Ashis K. Mukherjee; Maria Joao Ramos; Pedro Alexandrino Fernandes. "Unraveling the Reaction Mechanism of Russell’s Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?". Journal of Chemical Information and Modeling (2023): http://dx.doi.org/10.1021/acs.jcim.2c01156.
    10.1021/acs.jcim.2c01156
  4. Juliana Castro-Amorim; Ana Novo de Oliveira; Saulo Luís Da Silva; Andreimar M. Soares; Ashis K. Mukherjee; Maria Joao Ramos; Pedro Alexandrino Fernandes. "Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction". Journal of Medicinal Chemistry (2023): http://dx.doi.org/10.1021/acs.jmedchem.3c00097.
    10.1021/acs.jmedchem.3c00097
  5. Carlos F. M. Silva; Teresa Leão; Filipa Dias; Ana M. Tomás; Diana C. G. A. Pinto; Eduardo F. T. Oliveira; Ana Oliveira; Pedro A. Fernandes; Artur M. S. Silva. "Structure–Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania (Leishmania) infantum Promastigotes". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020669.
    10.3390/pharmaceutics15020669
  6. Ana Oliveira; LAQV/ REQUIMTE/ DQB/ FCUP. "Bases de Dados de Proteínas". Revista de Ciência Elementar 10 4 (2022): http://dx.doi.org/10.24927/rce2022.052.
    10.24927/rce2022.052
  7. "A combined experimental and computational study to discover novel tyrosinase inhibitors". Journal of Inorganic Biochemistry 234 (2022): 111879-111879. http://dx.doi.org/10.1016/j.jinorgbio.2022.111879.
    10.1016/j.jinorgbio.2022.111879
  8. Ana L. Oliveira; Matilde F. Viegas; Saulo L. da Silva; Andreimar M. Soares; Maria J. Ramos; Pedro A. Fernandes. "The chemistry of snake venom and its medicinal potential". Nature Reviews Chemistry (2022): https://doi.org/10.1038/s41570-022-00393-7.
    10.1038/s41570-022-00393-7
  9. Daniela Malafaia; Ana Oliveira; Pedro A. Fernandes; Maria J. Ramos; Hélio M. T. Albuquerque; Artur M. S. Silva. "Chromeno[3,4-b]xanthones as First-in-Class AChE and Aß Aggregation Dual-Inhibitors". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/8/4145.
    10.3390/ijms22084145
  10. Oliveira, Ana. "Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs.". Biochimie (2020): https://doi.org/10.1016/j.biochi.2020.11.023.
    10.1016/j.biochi.2020.11.023
  11. Oliveira, Ana. "Estrogen receptor-positive (ER+) breast cancer treatment: Are multi-target compounds the next promising approach?". Biochemical Pharmacology (2020): http://dx.doi.org/10.1016/j.bcp.2020.113989.
    10.1016/j.bcp.2020.113989
  12. Oliveira, Ana Oliveira. "Como criar um novo fármaco". Revista de Ciência Elementar 8 2 (2020): http://dx.doi.org/10.24927/rce2020.020.
    10.24927/rce2020.020
  13. Pinto, Alexandre V. Pinto; Oliveira, Ana N. L. Oliveira; Jerves, Carola Jerves; Mendonça, Filipa Lopes de Mendonça; Coutinho, Inês F. M. Coutinho; Coimbra, João T. S. Coimbra; Sousa, João P.M. Sousa; et al. "Proteínas Virais no Protein Data Bank". Revista de Ciência Elementar 8 2 (2020): http://dx.doi.org/10.24927/rce2020.022.
    10.24927/rce2020.022
  14. Oliveira, Ana. "Structural Specificity of Flavonoids in the Inhibition of Human Fructose 1,6-Bisphosphatase". Journal of Natural Products (2020): http://dx.doi.org/10.1021/acs.jnatprod.0c00014.
    10.1021/acs.jnatprod.0c00014
  15. Oliveira, Ana. "Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling". Reproductive Toxicology (2020): http://dx.doi.org/10.1016/j.reprotox.2020.01.003.
    10.1016/j.reprotox.2020.01.003
  16. Oliveira, Ana. "Anandamide targets aromatase: A breakthrough on human decidualization". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2019): http://dx.doi.org/10.1016/j.bbalip.2019.08.008.
    10.1016/j.bbalip.2019.08.008
  17. Oliveira, Ana. "Inhibition of translation termination by small molecules targeting ribosomal release factors". Scientific Reports (2019): http://dx.doi.org/10.1038/s41598-019-51977-1.
    10.1038/s41598-019-51977-1
  18. Vasile S; Esguerra M; Jespers W; Oliveira A; Sallander J; Åqvist J; Gutiérrez-de-Terán H. "Characterization of Ligand Binding to GPCRs Through Computational Methods.". Methods in molecular biology (Clifton, N.J.) (2018): http://europepmc.org/abstract/med/29188557.
    10.1007/978-1-4939-7465-8_2
  19. Oliveira, Ana. "Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors". Molecules (2017): http://dx.doi.org/10.3390/molecules22111945.
    10.3390/molecules22111945
  20. Hamnevik E; Enugala TR; Maurer D; Ntuku S; Oliveira A; Dobritzsch D; Widersten M. "Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer.". The FEBS journal (2017): http://europepmc.org/abstract/med/28963762.
    10.1111/febs.14279
  21. Lind C; Oliveira A; Åqvist J. "Origin of the omnipotence of eukaryotic release factor 1.". Nature communications (2017): http://europepmc.org/abstract/med/29127299.
    10.1038/s41467-017-01757-0
  22. Carbajales C; Azuaje J; Oliveira A; Loza MI; Brea J; Cadavid MI; Masaguer CF; et al. "Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates.". Journal of medicinal chemistry (2017): http://europepmc.org/abstract/med/28368607.
    10.1021/acs.jmedchem.7b00138
  23. Bharate SB; Singh B; Kachler S; Oliveira A; Kumar V; Bharate SS; Vishwakarma RA; Klotz KN; Gutiérrez de Terán H. "Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.". Journal of medicinal chemistry (2016): http://europepmc.org/abstract/med/27227326.
    10.1021/acs.jmedchem.6b00552
  24. Singh S; Thakur N; Oliveira A; Petruk AA; Hade MD; Sethi D; Bidon-Chanal A; et al. "Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling.". The Journal of biological chemistry (2014): http://europepmc.org/abstract/med/24928505.
    10.1074/jbc.m114.578187
  25. Singh, S.; Thakur, N.; Oliveira, A.; Petruk, A.A.; Hade, M.D.; Sethi, D.; Bidon-Chanal, A.; et al. "Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: Role of the CD loop and Pre-A motif in electron cycling". Journal of Biological Chemistry 289 31 (2014): 21573-21583. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905395528&partnerID=MN8TOARS.
    10.1074/jbc.M114.578187
  26. Oliveira A; Allegri A; Bidon-Chanal A; Knipp M; Roitberg AE; Abbruzzetti S; Viappiani C; Luque FJ. "Kinetics and computational studies of ligand migration in nitrophorin 7 and its ¿1-3 mutant.". Biochimica et biophysica acta (2013): http://europepmc.org/abstract/med/23624263.
    10.1016/j.bbapap.2013.04.009
  27. Oliveira, A.; Singh, S.; Bidon-Chanal, A.; Forti, F.; Martí, M.A.; Boechi, L.; Estrin, D.A.; Dikshit, K.L.; Luque, F.J.. "Role of PheE15 Gate in Ligand Entry and Nitric Oxide Detoxification Function of Mycobacterium tuberculosis Truncated Hemoglobin N". PLoS ONE 7 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869068674&partnerID=MN8TOARS.
    10.1371/journal.pone.0049291
Thesis / Dissertation
  1. "Theoretical study of ligand migration in Hemeproteins: Truncated Hemoglobin N and Nitrophorin 7". 2013. https://www.tdx.cat/handle/10803/307543#page=13.