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Maria José Borrego is a Researcher at the Portuguese National Institute of Health (Instituto Nacional de Saúde Doutor Ricardo Jorge, INSA, IP) where she works in the Department of Infectious Diseases, being the Head of the National Reference laboratory for Sexually Transmitted Infections. Thus she works mostly in Health Sciences. Se has published more than 55 papers in peer reviewed journals. Through her professional activity, Maria José has interacted with about 186 coauthors.
Identification

Personal identification

Full name
Maria José Borrego

Citation names

  • Borrego, Maria
  • Maria José Borrego
  • Borrego MJ

Author identifiers

Ciência ID
4812-0368-4249
ORCID iD
0000-0002-8604-8800

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Elementary (A2) Advanced (C1) Elementary (A2) Advanced (C1) Advanced (C1)
Education
Degree Classification
1993 - 1999/06/21
Concluded
Medicina Veterinária (Doutoramento)
Major in Microbiologia
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Aprovado
1986
Concluded
Medicina Veterinária (Licenciatura)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
15
Affiliation

Science

Category
Host institution
Employer
1999/06/21 - Current Auxiliary Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
1993 - 1999 Research Assistant (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
1989 - 1993 Research Trainee (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Positions / Appointments

Category
Host institution
Employer
2010/01/01 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Projects

Grant

Designation Funders
2020/04/01 - Current Genomic and transcriptomic traits driving intra-and-inter-patient evolution of clinically relevant Chlamydia trachomatis strains
SFRH/BD/147447/2019
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/01/01 - 2021/03/01 Genomics of Neisseria gonorrhoeae tropism and antimicrobial resistance
SFRH/BD/109264/2015
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2012/01/01 - 2016/09/30 Molecular dynamics of Chlamydia trachomatis chromosome and plasmid
SFRH/BD/68532/2010
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2015/07/31 Evolutionary dynamics of Chlamydia trachomatis genome and identification of molecular patterns of hypothetical protein coding genes
SFRH/BD/68527/2010
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/03 - 2015/06 Novel approach to "understand" syphilis Fundação para a Ciência e a Tecnologia, I.P.
2014/03 - 2015/03 Nova abordagem para compreensão da sífilis
EXPL/BIA-MIC/0309/2013
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2014/08 Characterisation of host cell pathways altered by effectors of Brucella, Chlamydia, and Coxiella: identification of novel therapeutic targets Fundação para a Ciência e a Tecnologia, I.P.
2009/08/01 - 2014/03/11 NEW APPROACHES FOR THE DIAGNOSIS OF HUMAN PAPILLOMAVIRUS INFECTION: RELEVANCE FOR CLINICAL PRACTICE AND CANCER PREVENTION
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F470442%F2008/PT
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2010/02 - 2013/07 Functional analyses of inclusion membrane proteins of Chlamydia trachomatis Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/06 Study of evasion mechanisms to innate immunity in group B streptococcal infections: identification of novel therapeutic targets. Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/03 Tracking the synthesis of the Chlamydia cell wall - a biological paradox in intracellular and evasive bacteria
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2008/01/01 - 2012/12/31 Molecular Epidemiology and virulence factors in Streptococcus agalactiae
SFRH/BD/48231/2008
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Concluded
2006/01/01 - 2011/06/30 Genomic and Transcriptomic features of Chlamydia trachomatis: tracking the basis for the ecological success
SFRH/BD/25651/2005
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded
1995/12/04 - 1996/12/31 Estudo da epidemiologia molecular e da patogenia das infeções causadas por Chlamydia trachomatis
BD/5246/95
PhD Student Fellow
Centre Hospitalier Universitaire Amiens-Picardie Site Nord, France
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/10/01 - 2021/09/30 Desenvolvimento e avaliação de um surfactante sob a forma de Hidrogel na prevenção de infecções transmitidas por contacto direto
PTDC/BIA-MIC/31561/2017
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/01/09 - 2020/01/03 TraSyph - Tracing the Treponema pallidum genetic footprints associated with syphilis outcomes and stages
TraSyph
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
European Society of Clinical Microbiology and Infectious Diseases
Ongoing
2015/01/02 - 2018/03/31 Inquérito Serológico Nacional 2015-2016
not applicable
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
EEA Grants
Concluded
2011/03/01 - 2014/08/31 Caracterização das vias celulares alteradas pelos efectores de Brucella, Chlamydia e Coxiella: identificação de novos alvos terapêuticos
ERA-PTG/0004/2010
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 457 - 2011-2012
PEst-OE/BIA/UI0457/2011
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Análises funcionais de proteínas da membrana de inclusão de Chlamydia trachomatis
PTDC/SAU-MII/099623/2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Estudo de mecanismos de evasão à imunidade inata na infecção por Estreptococcos do grupo B: identificação de novos alvos terapêuticos.
PTDC/SAU-MII/105114/2008
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/03/31 Análise da síntese da parede celular em Chlamydia - um paradoxo biológico numa bactéria intracelular e evasiva
PTDC/BIA-MIC/100747/2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 18 - 2011-2012
PEst-OE/SAU/LA0018/2011
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/04/30 Análise da estrutura mosaico do cromossoma de Chlamydia trachomatis por microarrays
PTDC/BIA-BCM/71117/2006
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2007/12/31 Epidemiologia molecular de Treponema pallidum
não tem
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Comissão de Fomento da Investigação em Cuidados de Saúde
Concluded
2002/01/01 - 2004/12/31 Variação genética das proteínas membranares polimórficas (pmp) nos genótipos de Chlamydia trachomatis
39822/MGI/2001
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002/01 - 2004/12 Variação genética das proteínas membranares polimórficas (pmp) nos genótipos de Chlamydia trachomatis
39822/MGI/2001
Fundação para a Ciência e a Tecnologia
1999/01/01 - 2001/12/31 Salpingites por Chlamydia trachomatis: estudo de fenómenos imunopatológicos responsáveis por infertilidade tubária na mulher
180/99
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Comissão de Fomento da Investigação em Cuidados de Saúde
Concluded
1993/01/01 - 1995/12/31 Investigação epidemiológica, laboratorial e clínica das doenças sexualmente transmissíveis e infecção pelo HIV/SIDA
PBIC/T/SAU1520/92
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1993/01 - 1995/12 Investigação epidemiológica, laboratorial e clínica das doenças sexualmente transmissíveis e infecção pelo HIV/SIDA
PBIC/T/SAU1520/92
Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2016/10/01 - 2021/02/28 Contribution of genomics and transcriptomics to the understanding of the biological role of DNases in Streptococcus agalactiae
não tem
Supervisor
Instituto Nacional de Saúde Doutor Ricardo Jorge IP Departamento de Doenças Infeciosas, Portugal
Ongoing
2018/01/02 - 2019/12/31 Estudo de vigilância da etiologia e prevalência em Portugal continental de 4 microrganismos (Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium e Trichomonas vaginalis) responsáveis por infeções sexualmente transmissíveis
não tem
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. Lopo S; C Roque; I Costa; Borrego MJ; J Azevedo. Corresponding author: Lopo S. "Genital herpes in a STD outpatient clinic in Lisbon". Paper presented in 19th Annual Meeting of the European Society for Clinical Virology, Lisbon, 2016.
    Published
Conference paper
  1. Nunes, A.; Ferreira, R.; Borges, V.; Borrego, M.J.; Gomes, João Paulo. "Molecular features underlying the higher ecological success of C. trachomatis E and F genotypes". 2011.
  2. Santo, I.; Azevedo, J.; Borrego, M.J.; Gomes, João Paulo; Verdasca, N.; Pista, A.. "Chlamydia trachomatis infection in patients selected for HPV detection". 2011.
  3. Borges, V.; Nunes, A.; Ferreira, R.; Borrego, M.J.; Gomes, João Paulo. "A Bioinformática na Identificação dos Processos Moleculares de Interacção entre o Agente Patogénico e o Homem". 2011.
  4. Ferreira, R.; Borges, V.; Nunes, A.; Borrego, M.J.; Gomes, João Paulo. "Transcriptomic analysis of plasmid and plasmid-related chromosomal ORFs in C. trachomatis strains with different cell-appetence". 2011.
Journal article
  1. Borges V; Duque MP; Martins JV; Vasconcelos P; Ferreira R; Sobral D; Pelerito A; et al. "Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.". Nature medicine (2023): http://europepmc.org/abstract/med/37696933.
    10.1038/s41591-023-02542-x
  2. Caldeira MB; Neves JM; Pestana M; Corte-Real R; Borrego MJ; Cordeiro R; Machado J; et al. "Demographic and Clinical Characteristics of Mpox Patients Attending an STD Clinic in Lisbon.". International journal of environmental research and public health (2023): http://europepmc.org/abstract/med/37835073.
    10.3390/ijerph20196803
  3. Rodrigues R; Vieira-Baptista P; Catalão C; Borrego MJ; Sousa C; Vale N. "Chlamydial and Gonococcal Genital Infections: A Narrative Review.". Journal of personalized medicine (2023): http://europepmc.org/abstract/med/37511783.
    10.3390/jpm13071170
  4. Caldeira M; Fernandes C; Neves J; João A; Calado R; Pinto AR; Borrego MJ; et al. "Outbreak of monkeypox in an STD clinic in Lisbon.". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/36268678.
    10.1111/jdv.18679
  5. Joana Isidro; Vítor Borges; Miguel Pinto; Daniel Sobral; João Dourado Santos; Alexandra Nunes; Verónica Mixão; et al. "Addendum: Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus". Nature Medicine (2022): https://doi.org/10.1038/s41591-022-02036-2.
    10.1038/s41591-022-02036-2
  6. Brazão C; Garrido PM; Alpalhão M; Roda Â; Vieitez-Frade J; Ferreira JA; Pelerito A; et al. "Monkeypox virus infection in HIV-1-coinfected patients previously vaccinated against smallpox: A series of 4 cases from Portugal.". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/36223385.
    10.1111/jdv.18655
  7. Alpalhão M; Sousa D; Frade JV; Patrocínio J; Garrido PM; Correia C; Brazão C; et al. "Human immunodeficiency virus infection may be a contributing factor to monkeypox infection: Analysis of a 42-case series.". Journal of the American Academy of Dermatology (2022): http://europepmc.org/abstract/med/36156305.
    10.1016/j.jaad.2022.09.029
  8. Inês Silvestre; Vítor Borges; Sílvia Duarte; Nunes, Alexandra; Rita Sobral; Luís Vieira; João Paulo Gomes; Maria José Borrego. "Global gene expression analysis of Streptococcus agalactiae at the exponential growth phase". Cellular and Molecular Biology 68 7 (2022): 1-8. http://dx.doi.org/10.14715/cmb/2022.68.7.1.
    10.14715/cmb/2022.68.7.1
  9. Alpalhão M; Frade JV; Sousa D; Patrocínio J; Garrido PM; Correia C; Brazão C; et al. "Monkeypox: a new (sexually transmissible) epidemic?". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/35841292.
    10.1111/jdv.18424
  10. Pereira IS; Pais SV; Borges V; Borrego MJ; Gomes JP; Mota LJ. "The Type III Secretion Effector CteG Mediates Host Cell Lytic Exit of Chlamydia trachomatis.". Frontiers in cellular and infection microbiology (2022): http://europepmc.org/abstract/med/35903198.
    10.3389/fcimb.2022.902210
  11. Joana Isidro; Vítor Borges; Miguel Pinto; Daniel Sobral; João Dourado Santos; Alexandra Nunes; Verónica Mixão; et al. "Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus". Nature Medicine (2022): https://doi.org/10.1038/s41591-022-01907-y.
    10.1038/s41591-022-01907-y
  12. Perez Duque M; Ribeiro S; Martins JV; Casaca P; Leite PP; Tavares M; Mansinho K; et al. "Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022.". Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin (2022): http://europepmc.org/abstract/med/35656830.
    10.2807/1560-7917.es.2022.27.22.2200424
  13. Day MJ; Jacobsson S; Spiteri G; Kulishev C; Sajedi N; Woodford N; Blumel B; et al. "Significant increase in azithromycin "resistance" and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019.". BMC infectious diseases (2022): http://europepmc.org/abstract/med/35672671.
    10.1186/s12879-022-07509-w
  14. Sánchez-Busó L; Cole MJ; Spiteri G; Day M; Jacobsson S; Golparian D; Sajedi N; et al. "Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study.". The Lancet. Microbe (2022): http://europepmc.org/abstract/med/35659907.
    10.1016/s2666-5247(22)00044-1
  15. Cole MJ; Day M; Jacobsson S; Amato-Gauci AJ; Spiteri G; Unemo M; the European Gonorrhoea Response Plan Group; European Gonorrhoea Response Plan Group. "The European response to control and manage multi- and extensively drug-resistant Neisseria gonorrhoeae.". Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin (2022): http://europepmc.org/abstract/med/35514307.
    10.2807/1560-7917.es.2022.27.18.2100611
  16. Bonito F; Alves J; Lodhia Z; Cordeiro D; Borges V; Azevedo J; Borrego MJ. "Clinical and epidemiological characterization of lymphogranuloma venereum in a sexually transmitted diseases clinic in Lisbon, 2001-2020.". Sexually transmitted diseases (2022): http://europepmc.org/abstract/med/35404912.
    10.1097/olq.0000000000001634
  17. Borges, Vítor; Isidro, Joana; Trovão, Nídia Sequeira; Duarte, Sílvia; Cortes-Martins, Helena; Martiniano, Hugo; Gordo, Isabel; et al. "SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal". Communications Medicine 2 1 (2022): http://dx.doi.org/10.1038/s43856-022-00072-0.
    Open access • Published • 10.1038/s43856-022-00072-0
  18. Silvestre I; Nunes A; Borges V; Isidro J; Silva C; Vieira L; Gomes JP; Borrego MJ. "Genomic insights on DNase production in Streptococcus agalactiae ST17 and ST19 strains.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2021): http://europepmc.org/abstract/med/34147652.
    10.1016/j.meegid.2021.104969
  19. Neves JM; Ramos Pinheiro R; Côrte-Real R; Borrego MJ; Rodrigues A; Fernandes C. "Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center.". Journal of the European Academy of Dermatology and Venereology : JEADV (2021): http://europepmc.org/abstract/med/33896044.
    10.1111/jdv.17302
  20. Jacobsson, Susanne; Cole, Michelle J.; Spiteri, Gianfranco; Day, Michaela; Unemo, Magnus. "Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016". BMC Infectious Diseases 21 1 (2021): http://dx.doi.org/10.1186/s12879-021-05931-0.
    10.1186/s12879-021-05931-0
  21. Unemo, Magnus; Ahlstrand, Josefine; Sánchez-Busó, Leonor; Day, Michaela; Aanensen, David; Golparian, Daniel; Jacobsson, Susanne; et al. "High susceptibility to zoliflodacin and conserved target (GyrB) for zoliflodacin among 1209 consecutive clinical Neisseria gonorrhoeae isolates from 25 European countries, 2018". Journal of Antimicrobial Chemotherapy (2021): http://dx.doi.org/10.1093/jac/dkab024.
    10.1093/jac/dkab024
  22. Borges, Vítor; Isidro, Joana; Correia, Cristina; Cordeiro, Dora; Vieira, Luís; Lodhia, Zohra; Fernandes, Cândida; et al. "Transcontinental dissemination of the L2b/D-Da recombinant Chlamydia trachomatis Lymphogranuloma venereum (LGV) strain: need of broad multi-country molecular surveillance". Clinical Infectious Diseases (2021): http://dx.doi.org/10.1093/cid/ciab067.
    10.1093/cid/ciab067
  23. Hadad R; Cole MJ; Ebeyan S; Jacobsson S; Tan LY; Golparian D; Erskine S; et al. "Evaluation of the SpeeDx ResistancePlus® GC and SpeeDx GC 23S 2611 (beta) molecular assays for prediction of antimicrobial resistance/susceptibility to ciprofloxacin and azithromycin in Neisseria gonorrhoeae.". The Journal of antimicrobial chemotherapy (2021): http://europepmc.org/abstract/med/32929456.
    10.1093/jac/dkaa381
  24. Miguel Pinto; Vítor Borges; Joana Isidro; João Carlos Rodrigues; Luís Vieira; Maria José Borrego; João Paulo Gomes. "Neisseria gonorrhoeae clustering to reveal major European whole-genome-sequencing-based genogroups in association with antimicrobial resistance". Microbial Genomics (2020): https://doi.org/10.1099/mgen.0.000481.
    10.1099/mgen.0.000481
  25. Maria José Borrego. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections (2020): 1-58. http://dx.doi.org/10.1080/22221751.2020.1844552.
    10.1080/22221751.2020.1844552
  26. Maria José Borrego. "Biofilm formation by ST17 and ST19 strains of Streptococcus agalactiae". Research in Microbiology (2020): http://dx.doi.org/10.1016/j.resmic.2020.08.001.
    10.1016/j.resmic.2020.08.001
  27. Maria José Borrego. "Cephalosporin-resistant Neisseria gonorrhoeae isolated in Portugal, 2019". Sexually Transmitted Diseases Publish Ah (2020): http://dx.doi.org/10.1097/olq.0000000000001218.
    10.1097/olq.0000000000001218
  28. Pinto M; Rodrigues JC; Matias R; Água-Doce I; Cordeiro D; Correia C; Gomes JP; et al. "Fifteen years of a nationwide culture collection of Neisseria gonorrhoeae antimicrobial resistance in Portugal.". European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2020): http://europepmc.org/abstract/med/32494956.
    Accepted • 10.1007/s10096-020-03907-7
  29. Cole, Michelle J.; Quinten, Chantal; Jacobsson, Susanne; Day, Michaela; Amato-Gauci, Andrew J.; Woodford, Neil; Spiteri, Gianfranco; Unemo, Magnus. "The European gonococcal antimicrobial surveillance programme (Euro-GASP) appropriately reflects the antimicrobial resistance situation for Neisseria gonorrhoeae in the European Union/European Economic Area". BMC Infectious Diseases 19 1 (2019): http://dx.doi.org/10.1186/s12879-019-4631-x.
    Published • 10.1186/s12879-019-4631-x
  30. Borges, Vítor; Cordeiro, Dora; Salas, Ana Isabel; Lodhia, Zohra; Correia, Cristina; Isidro, Joana; Fernandes, Cândida; et al. "Chlamydia trachomatis: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature". Microbial Genomics 5 11 (2019): http://dx.doi.org/10.1099/mgen.0.000313.
    Published • 10.1099/mgen.0.000313
  31. Cole MJ; Quaye N; Jacobsson S; Day M; Fagan E; Ison C; Pitt R; et al. "Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data.". BMC infectious diseases 19 (2019): http://europepmc.org/abstract/med/30909883.
    Published • 10.1186/s12879-019-3900-z
  32. Borrego, Maria. "Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon STD clinic". International Journal of STD & AIDS (2019):
    Accepted
  33. Florindo, Carlos; Barroco, Cinthia Alves; Silvestre, Inês; Damião, Vera; Gomes, João Paulo; Spellerberg, Barbara; Santos-Sanches, Ilda; Borrego, Maria José. "Capsular Type, Sequence Type and Microbial Resistance Factors Impact on DNase Activity of Streptococcus agalactiae Strains from Human and Bovine Origin". European Journal of Microbiology and Immunology 8 4 (2018): 149-154. http://dx.doi.org/10.1556/1886.2018.00026.
    10.1556/1886.2018.00026
  34. Day, Michaela J.; Spiteri, Gianfranco; Jacobsson, Susanne; Woodford, Neil; Amato-Gauci, Andrew J.; Cole, Michelle J.; Unemo, Magnus. "Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016". BMC Infectious Diseases 18 1 (2018): http://dx.doi.org/10.1186/s12879-018-3528-4.
    Published • 10.1186/s12879-018-3528-4
  35. Harris, Simon R; Cole, Michelle J; Spiteri, Gianfranco; Sánchez-Busó, Leonor; Golparian, Daniel; Jacobsson, Susanne; Goater, Richard; et al. "Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey". The Lancet Infectious Diseases 18 7 (2018): 758-768. http://dx.doi.org/10.1016/s1473-3099(18)30225-1.
    10.1016/s1473-3099(18)30225-1
  36. Borrego, Maria. "Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015.". BMC infectious diseases (2017): http://europepmc.org/abstract/med/28893203.
    10.1186/s12879-017-2707-z
  37. Borrego, Maria. "Global survey of mRNA levels and decay rates of Chlamydia trachomatis trachoma and lymphogranuloma venereum biovars.". Heliyon (2017): http://europepmc.org/abstract/med/28795162.
    10.1016/j.heliyon.2017.e00364
  38. Pinto M; Antelo M; Ferreira R; Azevedo J; Santo I; Borrego MJ; Gomes JP. "A retrospective cross-sectional quantitative molecular approach in biological samples from patients with syphilis.". (2017): http://europepmc.org/abstract/med/28161356.
    10.1016/j.micpath.2017.01.059
  39. Borrego, Maria. "Parallel Evolution of Group B Streptococcus Hypervirulent Clonal Complex 17 Unveils New Pathoadaptive Mutations.". mSystems (2017): http://europepmc.org/abstract/med/28904998.
    10.1128/msystems.00074-17
  40. Jacobsson S; Golparian D; Cole M; Spiteri G; Martin I; Bergheim T; Borrego MJ; et al. "WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014.". (2016): http://europepmc.org/abstract/med/27432597.
  41. Pinto M; Borges V; Antelo M; Pinheiro M; Nunes A; Azevedo J; Borrego MJ; et al. "Genome-scale analysis of the non-cultivable Treponema pallidum reveals extensive within-patient genetic variation.". (2016): http://europepmc.org/abstract/med/27748767.
    10.1038/nmicrobiol.2016.190
  42. Inácio ÂS; Nunes A; Milho C; Mota LJ; Borrego MJ; Gomes JP; Vaz WL; Vieira OV. "In Vitro Activity of Quaternary Ammonium Surfactants against Streptococcal, Chlamydial, and Gonococcal Infective Agents.". (2016): http://europepmc.org/abstract/med/26976875.
    10.1128/aac.00166-16
  43. Inácio ÂS; Domingues NS; Nunes A; Martins PT; Moreno MJ; Estronca LM; Fernandes R; et al. "Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in antibacterial prophylaxis.". (2016): http://europepmc.org/abstract/med/26679255.
    10.1093/jac/dkv405
  44. Cole MJ; Spiteri G; Jacobsson S; Pitt R; Grigorjev V; Unemo M; Euro-GASP Network. "Is the tide turning again for cephalosporin resistance in Neisseria gonorrhoeae in Europe? Results from the 2013 European surveillance.". (2015): http://europepmc.org/abstract/med/26259560.
    10.1186/s12879-015-1013-x
  45. Borrego, Maria; Ferreira, R.; Antelo, M.; Nunes, A.; Borges, V.; Damião, V.; Borrego, M.J.; Gomes, João Paulo. "In Silico Scrutiny of Genes Revealing Phylogenetic Congruence with Clinical Prevalence or Tropism Properties of Chlamydia trachomatis Strains". (2015): http://hdl.handle.net/10400.18/2971.
    10.1534/g3.114.015354
  46. Borges V; Pinheiro M; Antelo M; Sampaio DA; Vieira L; Ferreira R; Nunes A; et al. "Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.". (2015): http://europepmc.org/abstract/med/26207372.
    10.1371/journal.pone.0133420
  47. Cole MJ; Spiteri G; Town K; Unemo M; Hoffmann S; Chisholm SA; Amato-Gauci AJ; et al. "Risk factors for antimicrobial-resistant Neisseria gonorrhoeae in Europe.". (2014): http://europepmc.org/abstract/med/25581808.
    10.1097/olq.0000000000000185
  48. da Cunha M; Milho C; Almeida F; Pais SV; Borges V; Maurício R; Borrego MJ; et al. "Identification of type III secretion substrates of Chlamydia trachomatis using Yersinia enterocolitica as a heterologous system.". (2014): http://europepmc.org/abstract/med/24533538.
    10.1186/1471-2180-14-40
  49. Florindo C; Damiao V; Silvestre I; Farinha C; Rodrigues F; Nogueira F; Martins-Pereira F; et al. "Epidemiological surveillance of colonising group B Streptococcus epidemiology in the Lisbon and Tagus Valley regions, Portugal (2005 to 2012): emergence of a new epidemic type IV/clonal complex 17 clone.". (2014): http://europepmc.org/abstract/med/24957747.
  50. Rodrigues, J.C.; Reis, L.; Cordeiro, D.; João, Inês; Diniz, M.; Nunes, A.; Florindo, C.; et al. "Vigilância laboratorial das infeções por Neisseria gonorrhoeae em Portugal, 2004-2013". (2014): http://hdl.handle.net/10400.18/2382.
  51. Ferreira, R.; Antelo, M.; Nunes, A.; Borges, V.; Damião, V.; Borrego, M.J.; Gomes, João Paulo. "In silico scrutiny of genes revealing phylogenetic congruence with clinical prevalence or tropism properties of Chlamydia trachomatis strains". (2014): http://hdl.handle.net/10400.18/3161.
    10.1534/g3.114.015354
  52. Florindo, C; Damião, V; Lima, J; Nogueira, I; Rocha, I; Caetano, P; Ribeiro, L; et al. "Accuracy of prenatal culture in predicting intrapartum group B streptococcus colonization status". (2014): http://hdl.handle.net/10400.10/1755.
    10.3109/14767058.2013.820700.
  53. Borges V; Ferreira R; Nunes A; Sousa-Uva M; Abreu M; Borrego MJ; Gomes JP. "Effect of long-term laboratory propagation on Chlamydia trachomatis genome dynamics.". (2013): http://europepmc.org/abstract/med/23542454.
    10.1016/j.meegid.2013.03.035
  54. Ferreira R; Borges V; Nunes A; Borrego MJ; Gomes JP. "Assessment of the load and transcriptional dynamics of Chlamydia trachomatis plasmid according to strains' tissue tropism.". (2013): http://europepmc.org/abstract/med/23590987.
    10.1016/j.micres.2013.02.001
  55. Nunes A; Borrego MJ; Gomes JP. "Genomic features beyond Chlamydia trachomatis phenotypes: what do we think we know?". (2013): http://europepmc.org/abstract/med/23523596.
    10.1016/j.meegid.2013.03.018
  56. Silva S; Henriques R; Borrego MJ; Gomes JP; Afonso E. "Congenital neurosyphilis - authors' reply.". (2013): http://europepmc.org/abstract/med/23718919.
    10.1016/S1473-3099(13)70123-3
  57. Almeida F; Borges V; Ferreira R; Borrego MJ; Gomes JP; Mota LJ. "Polymorphisms in inc proteins and differential expression of inc genes among Chlamydia trachomatis strains correlate with invasiveness and tropism of lymphogranuloma venereum isolates.". (2012): http://europepmc.org/abstract/med/23042990.
    10.1128/JB.01428-12
  58. Borges V; Nunes A; Ferreira R; Borrego MJ; Gomes JP. "Directional evolution of Chlamydia trachomatis towards niche-specific adaptation.". (2012): http://europepmc.org/abstract/med/22961851.
    10.1128/JB.01291-12
  59. Silva S; Henriques R; Gomes JP; Borrego MJ; Afonso E. "Could we miss congenital neurosyphilis?". (2012): http://europepmc.org/abstract/med/23017366.
    10.1016/S1473-3099(12)70059-2
  60. Florindo C; Ferreira R; Borges V; Spellerberg B; Gomes JP; Borrego MJ. "Selection of reference genes for real-time expression studies in Streptococcus agalactiae.". (2012): http://europepmc.org/abstract/med/22634000.
    10.1016/j.mimet.2012.05.011
  61. Ferreira R; Borges V; Nunes A; Nogueira PJ; Borrego MJ; Gomes JP. "Impact of loci nature on estimating recombination and mutation rates in Chlamydia trachomatis.". (2012): http://europepmc.org/abstract/med/22870399.
    10.1534/g3.112.002923
  62. Tavares, E; Fernandes, C; Borrego, MJ; Rodrigues, A; Cardoso, J. "Resistência aos Antibióticos em Neisseria Gonorrhoeae - Passado, Presente e Futuro". (2012): http://hdl.handle.net/10400.17/1396.
  63. Santo I; Azevedo J; Nunes B; Gomes JP; Borrego MJ; Santo, I.; Azevedo, J.; et al. "Partner notification for chlamydia trachomatis urogenital infections: eight years of patient referral experience in the major Portuguese sexually transmitted infections clinic, 2000-07.". (2011): http://europepmc.org/abstract/med/21998173.
    10.1258/ijsa.2011.010268
  64. Florindo C; Gomes JP; Rato MG; Bernardino L; Spellerberg B; Santos-Sanches I; Borrego MJ. "Molecular epidemiology of group B streptococcal meningitis in children beyond the neonatal period from Angola.". (2011): http://europepmc.org/abstract/med/21474607.
    10.1099/jmm.0.031674-0
  65. Florindo, C.; Gomes, João Paulo; Rato, M.G.; Bernardino, L.; Spellerberg, B.; Santos-Sanches, I.; Borrego, M.J.. "Molecular epidemiology of group B streptococcal". (2011): http://hdl.handle.net/10400.18/634.
    doi:10.1099/jmm.0.031674-0
  66. Florindo C; Pereira R; Boura M; Nunes B; Paulino A; Gomes JP; Borrego MJ. "Genotypes and antimicrobial-resistant phenotypes of Neisseria gonorrhoeae in Portugal (2004-2009).". (2010): http://europepmc.org/abstract/med/20940158.
    10.1136/sti.2010.044321
  67. Cole MJ; Chisholm SA; Hoffmann S; Stary A; Lowndes CM; Ison CA; European Surveillance of Sexually Transmitted Infections Network. "European surveillance of antimicrobial resistance in Neisseria gonorrhoeae.". (2010): http://europepmc.org/abstract/med/20940154.
    10.1136/sti.2010.044164
  68. Florindo C; Viegas S; Paulino A; Rodrigues E; Gomes JP; Borrego MJ. "Molecular characterization and antimicrobial susceptibility profiles in Streptococcus agalactiae colonizing strains: association of erythromycin resistance with subtype III-1 genetic clone family.". (2010): http://europepmc.org/abstract/med/19886900.
    10.1111/j.1469-0691.2010.03106.x
  69. Borges V; Ferreira R; Nunes A; Nogueira P; Borrego MJ; Gomes JP; Borges, V.; et al. "Normalization strategies for real-time expression data in Chlamydia trachomatis.". (2010): http://europepmc.org/abstract/med/20619305.
    10.1016/j.mimet.2010.06.013
  70. Nunes, A.; Nogueira, P.J.; Borrego, M.J.; Gomes, João Paulo; Nunes A; Nogueira PJ; Borrego MJ; Gomes JP. "Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distinct evolutionary scenarios for B- and T-cell epitopes: worldwide survey". (2010): http://hdl.handle.net/10400.18/135.
    10.1371/journal.pone.0013171
  71. Nunes A; Borrego MJ; Nunes B; Florindo C; Gomes JP. "Evolutionary dynamics of ompA, the gene encoding the Chlamydia trachomatis key antigen.". (2009): http://europepmc.org/abstract/med/19783629.
    10.1128/JB.00895-09
  72. Gomes JP; Nunes A; Florindo C; Ferreira MA; Santo I; Azevedo J; Borrego MJ. "Lymphogranuloma venereum in Portugal: unusual events and new variants during 2007.". (2009): http://europepmc.org/abstract/med/19125144.
    10.1097/OLQ.0b013e31818b1e27
  73. Savage EJ; van de Laar MJ; Gallay A; van der Sande M; Hamouda O; Sasse A; Hoffmann S; et al. "Lymphogranuloma venereum in Europe, 2003-2008.". (2009): http://europepmc.org/abstract/med/20003898.
  74. Savage EJ; Hughes G; Ison C; Lowndes CM; European Surveillance of Sexually Transmitted Infections network. "Syphilis and gonorrhoea in men who have sex with men: a European overview.". (2009): http://europepmc.org/abstract/med/19941803.
  75. Florindo C; Reigado V; Gomes JP; Azevedo J; Santo I; Borrego MJ. "Molecular typing of treponema pallidum clinical strains from Lisbon, Portugal.". (2008): http://europepmc.org/abstract/med/18753355.
    10.1128/JCM.00128-08
  76. Nunes A; Nogueira PJ; Borrego MJ; Gomes JP. "Chlamydia trachomatis diversity viewed as a tissue-specific coevolutionary arms race.". (2008): http://europepmc.org/abstract/med/18947394.
    10.1186/gb-2008-9-10-r153
  77. Martins ER; Florindo C; Martins F; Aldir I; Borrego MJ; Brum L; Ramirez M; Melo-Cristino J. "Streptococcus agalactiae serotype Ib as an agent of meningitis in two adult nonpregnant women.". (2007): http://europepmc.org/abstract/med/17881554.
    10.1128/JCM.01358-07
  78. Gomes JP; Bruno WJ; Nunes A; Santos N; Florindo C; Borrego MJ; Dean D. "Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots.". (2007): http://europepmc.org/abstract/med/17090662.
    10.1101/gr.5674706
  79. Nunes A; Gomes JP; Mead S; Florindo C; Correia H; Borrego MJ; Dean D. "Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains.". (2007): http://europepmc.org/abstract/med/17849007.
    10.1371/journal.pone.0000878
  80. Gomes JP; Borrego MJ; Atik B; Santo I; Azevedo J; Brito de Sá A; Nogueira P; Dean D. "Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis.". (2006): http://europepmc.org/abstract/med/16289001.
    10.1016/j.micinf.2005.05.014
  81. Gomes JP; Nunes A; Bruno WJ; Borrego MJ; Florindo C; Dean D. "Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: evidence for serovar Da recombination and correlation with tissue tropism.". (2006): http://europepmc.org/abstract/med/16352844.
    10.1128/JB.188.1.275-286.2006
  82. Gomes JP; Hsia RC; Mead S; Borrego MJ; Dean D. "Immunoreactivity and differential developmental expression of known and putative Chlamydia trachomatis membrane proteins for biologically variant serovars representing distinct disease groups.". (2005): http://europepmc.org/abstract/med/15784185.
    10.1016/j.micinf.2004.11.014
  83. Gomes JP; Bruno WJ; Borrego MJ; Dean D. "Recombination in the genome of Chlamydia trachomatis involving the polymorphic membrane protein C gene relative to ompA and evidence for horizontal gene transfer.". (2004): http://europepmc.org/abstract/med/15205432.
    10.1128/JB.186.13.4295-4306.2004
  84. Betsou F; Borrego MJ; Guillaume N; Catry MA; Romão S; Machado-Caetano JA; Sueur JM; et al. "Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor.". (2003): http://europepmc.org/abstract/med/12738647.
    10.1128/CDLI.10.3.446-450.2003
  85. Borrego MJ; Gomes JP; Lefebvre JF; Eb F; Orfila J; Catry MA. "Genotyping of Portuguese Chlamydia trachomatis urogenital isolates.". (1997): http://europepmc.org/abstract/med/9582485.
  86. Borrego MJ; Ferraz-Oliveira F; Fadia F; Torgal J; Catry MA. "[Genotype of C. trachomatis strains isolated in a region of Guinea-Bissau: Farim]". (1996): http://europepmc.org/abstract/med/9889569.
  87. Guerreiro D; Borrego MJ; Teles Lda C; Catry MD. "[Chlamydia trachomatis in family planning. Is screening necessary?].". (1996): http://europepmc.org/abstract/med/9005688.
  88. Catry MA; Borrego MJ; Cardoso J; Azevedo J; Santo I. "Comparison of the Amplicor Chlamydia trachomatis test and cell culture for the detection of urogenital chlamydial infections.". (1995): http://europepmc.org/abstract/med/7590718.
Preprint
  1. João Paulo Gomes; Joana Isidro; Vitor Borges; Miguel Pinto; Daniel Sobral; João Santos; Verónica Mixão; et al. "Multi-country outbreak of monkeypox virus: phylogenomic characterization and signs of microevolution". 2022. https://doi.org/10.21203/rs.3.rs-1700947/v1.
    10.21203/rs.3.rs-1700947/v1
  2. Borges V; Cordeiro D; Salas AI; Lodhia Z; Correia C; Isidro J; Fernandes C; et al. "Chlamydia trachomatisoutbreak: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature". 2019. http://europepmc.org/abstract/PPR/PPR77629.
    10.1101/622324

Other

Other output
  1. Genomic insights on DNase production in Streptococcus agalactiae ST17 and ST19 strains. 2020. Inês Silvestre; Alexandra Nunes; Vítor Borges; Joana Isidro; Catarina Silva; Luís Vieira; João Paulo Gomes; Maria José Borrego. https://doi.org/10.1101/2020.12.09.418327.
    10.1101/2020.12.09.418327
  2. Global gene expression analysis of Streptococcus agalactiae at exponential growth phase. 2020. Inês Silvestre; Vítor Borges; Sílvia Duarte; Alexandra Nunes; Rita Sobral; Luís Vieira; João Paulo Gomes; Maria José Borrego. https://doi.org/10.1101/2020.11.13.381939.
    10.1101/2020.11.13.381939