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André Sousa concludes his bachelor's in Medicinal Biotechnology in 2019 at the Polytechnic Institute of Porto. In 2021, in the same institute, he has finished his master's in Health Biochemistry. Currently, his main focus is on metabolism and cancer progression, studying a variety of in vitro areas such as inflammation, molecular signaling, central metabolism, and proliferation mechanisms. Presently, he is endorsed in the Ph.D. program of Metabolism, clinic, and experimentation by the Medicine Faculty of Porto University, and his dissertation will focus on the evaluation of the paradox between prostate cancer and type 2 Diabetes Mellitus.
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Identification

Personal identification

Full name
André Miguel Pinto de Sousa

Citation names

  • André P Sousa

Author identifiers

Ciência ID
471F-9426-6FFD
ORCID iD
0000-0003-1460-5361

Email addresses

  • andre.mp.sousa2@hotmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Spanish; Castilian Intermediate (B1) Elementary (A2) Elementary (A2) Upper intermediate (B2) Beginner (A1)
Education
Degree Classification
2021/09/13 - 2025
Ongoing
 Metabolismo - Clínica e Experimentação (Doutoramento)
Major in Metabolismo
Universidade do Porto Faculdade de Medicina, Portugal
"Study of metabolic and biochemical implications of diabetes in prostate cancer patients - the upcoming paradox " (THESIS/DISSERTATION)
2019/10/10 - 2021/12/14
Concluded
 Bioquímica em Saúde (Mestrado)
Major in Bioquímica clínica e metabólica
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
"Unraveling prostate cancer paradox - molecular, metabolic, and cytometric mechanisms in type 2 diabetes and metabolic syndrome." (THESIS/DISSERTATION)
 19
2016/10/10 - 2019/07/02
Concluded
 Biotecnologia Medicinal (Licenciatura)
Major in Biotecnologia
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
"Metabolismo de células tumorais em obesidade" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2020/01/03 - Current Research Assistant (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2022/10/01 - 2026/09/30 Researcher (Research) Associação para a Inovação e Desenvolvimento da FCT, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
(...)
2021/02/01 - 2022/09/30 Researcher (Research) Instituto Politécnico do Porto, Portugal
Instituto Politécnico do Porto, Portugal
2019/04/01 - 2019/06/30 Research Trainee (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2021/02/01 - 2024/02/29 IPP4COVID - Prevention and Sustainable Optimization of the Diagnosis of COVID-19 on a Large Scale
IPP4COVID/02/2020
Research Fellow
Instituto Politécnico do Porto, Portugal
Ongoing

Other

Designation Funders
2023/01/01 - 2024/07/01 Use of Aptamers towards Theranostics and Precision Medicine in Prostate Carcinoma
2022.09032.PTDC
Researcher
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2020 - 2020/08 IPP4AFA - Support for SARS-CoV-2 molecular diagnosis at ACES Entre Douro e Vouga || Feira/Arouca
104_596694627
Volunteer
LaBMI | PORTIC | PPORTO, Portugal
Concluded
2020 - 2020/08 IPP4AVSS - Support for SARS-CoV-2 molecular diagnosis at ACES Tamega || Vale do Sousa Sul
112_596698921
Volunteer
LaBMI | PORTIC | PPORTO, Portugal
Concluded
Outputs

Publications

Book
  1. Caderno de Diagnóstico Molecular e Química Clínica. Porto, Portugal. 2021.
    Published
Book chapter
  1. "Biologia da doença; Fluorescência; PCR's; Estudo de cromossomas e as suas alterações; Domínios de Imunoglobolinas; O rim e a sua função; Equilíbrio e desequilíbrio ácido-base; Fígado e função biliar; Urianálise.". In Caderno de Diagnóstico Molecular e Química Clínica. Porto, Portugal, 2021.
    Published
  2. "Ciência de animais de laboratório; Biotérios; Modelos animais; Ética, legislação e bem-estar animal.". In Introduçãoà ciência de animais de laboratório. Porto, Portugal, 2021.
    Published
  3. "Análise de níveis/dados de expressão com o reactome; Pesquisa in silico de novas drogas e alvos terapêuticos.". In Introdução à Bioinformática e Biologia Computacional. Porto, Portugal, 2021.
    Published
Conference abstract
  1. Costa, R., Sousa, A. P., Soares, R. and Gomes, A.. "Prostate Cancer Cell Lines Inhibition by Umbilical Cord Blood Serum". Paper presented in Cord Blood Connect, 2021.
    Published
  2. Teixeira, C., Guedes, C., Sousa, A. P., Lopes, S., Luís, C., Soares, R., Baylina, P., Moreira, F., Alencastre I. and Fer. "Alterações morfopatológicas no rim de rato com obesidade e insulino-resistência". Paper presented in 17º Portuguese Diabetes Congress, Vilamoura, 2021.
    Published
  3. Sousa, A. P., Luís, C., Lopes, S., Guedes, C., Teixeira, C., Rigor, J., Mendes-Martins, D., Costa, R., Soares, R., Bayli. "Efeito da testosterona e estradiol no paradoxo diabetes/cancro de próstata". Paper presented in 17º Portuguese Diabetes Congress, Vilamoura, 2021.
    Published
  4. Sousa, A., Lopes, S., Luís, C., Guedes, C., Teixeira, C., Rigor, J., Mendes, D., Costa, R., Duarte, F., Soares, R., Bayl. "Avaliação do potencial anti tumoral de fármacos antidiabéticos em cancro de próstata". Paper presented in 17º Portuguese Diabetes Congress, Vilamoura, 2021.
    Published
  5. Sousa, A. P., Luís, C., Rigor, J., Barbosa, J., Martins, D., Costa, R. and Fernandes, R.. "Prostate cancer cell Pc3 behavior under a simulated type 2 diabetic microenvironment". Paper presented in 16º Portuguese Diabetes Congress, Vilamoura, 2020.
    Published
Conference poster
  1. Frantz Gojon; André P Sousa; Rocha, Ana Catarina; Claúdia Sousa-Mendes ; Ilda Rodrigues ; Raquel Soares; Raquel Costa; Fernandes, Ruben. "Influência de membranas de policaprolactona na remodelação celular de um modelo animal de úlceras de pé diabético". Paper presented in 19º Congresso Português de Diabetes, 2023.
  2. André P Sousa; Rocha, Ana Catarina; Raquel Soares; Pilar Baylina; Raquel Costa; Marco G. Alves ; Fernandes, Ruben. Corresponding author: Fernandes, Ruben. "Influência de doenças metabólicas na modelação de vias de sinalização de um modelo celular de cancro de próstata". Paper presented in 19º Congresso Português de Diabetes, 2023.
  3. André P Sousa; José M. Coelho Macedo ; Patrick Pais; Rocha, Ana Catarina; Raquel Soares; Pilar Baylina; Raquel Costa; Marco G. Alves ; Fernandes, Ruben. Corresponding author: Fernandes, Ruben. "Efeito da exposição de produtos de glicação avançada (AGE) em modelos celulares de epitélio tumoral e não tumoral de próstata". Paper presented in 19º Congresso Português de Diabe, 2023.
  4. Rocha, Ana Catarina; André P Sousa; Teixeira, Catarina; Almeida, Cátia; Baylina, Pilar; Soares, Raquel; Martins-Mendes, Daniela; Fernandes, Ruben. "Adiposidade promovida pela Pioglitazona potencia a agressividade de tumores do pâncreas em pacientes obesos". Paper presented in 19º Congresso Português de Diabetes, 2023.
  5. Aveiro, Alexandra; Soares-Guedes, Carla; André P Sousa; Teixeira, Catarina; Baylina Machado, Pilar; Pereira, Ana. "The influence of adipocytes¿ secretome and imune response on bacterial growth". Paper presented in 1st Conference of the Doctoral Program in Metabolism ¿ Clinical and experimental, 2022.
  6. Aveiro, Alexandra; Soares-Guedes, Carla; André P Sousa; Teixeira, Catarina; Baylina Machado, Pilar; Pereira, Ana. "The influence of secretome adipocytes on bacterial infections and immune response". Paper presented in 1st Conference of the Doctoral Program in Metabolism Clinical and Experimental, 2022.
  7. Oliveira, Marco; Soares, Sílvia; André P Sousa; Teixeira, Catarina; Correa-Duarte, Miguel; Carla F. Pereira; Baylina Machado, Pilar; Fernandes, Ruben. "Otimização da biossíntese de nanopartículas de ouro e o seu potencial terapêutico no cancro da próstata". Paper presented in 4º ENCONTRO NACIONAL JOVENS INVESTIGADORES EM ONCOLOGIA - Liga Portuguesa Contra o Cancro, 2022.
  8. Costa, R., Sousa, A. P., Leite, F., Soares, R. and Gomes, A.. "Umbilical Cord Mesenchymal Stem Cell Secretome Inhibitory Effects in Prostate Cancer Cell Lines". Paper presented in Cell Bio Virtual 2021-An Online ASCB|EMBO Meeting, 2021.
  9. Sousa, A. P., Soares, R., Fernandes, R., Costa, R., and Gomes, A.. "Umbilical cord blood serum potential anti-tumor effects in prostate cancer". Paper presented in ASPIC-ASEICA international meeting, 2021.
  10. Sousa, A. P., Soares, S., Alves, M. G., Soares, R., Baylina, P., Costa, R. and Fernandes, R.. "PCa paradox - biochemical and metabolic state between prostate cancer and diabetes mellitus type 2". Paper presented in ASPIC-ASEICA international meeting, 2021.
  11. Sousa, A., Leite, F., Soares, R., Gomes, A. and Costa, R.. "Umbilical cord mesenchymal stem cells secretome suppresses prostate cancer through the activation of p53 pathway". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, 2021.
  12. Costa, R., Sousa, A. P., Soares, R. and Gomes, A.. "Prostate Cancer Cell Lines Inhibition by Umbilical Cord Blood Serum". Paper presented in Cord Blood Connect, 2021.
  13. Oliveira, M., Soares, S., Sousa, A. P., Correa-Duarte, M., Baylina, P. and Fernandes, R.. "Biosynthesis of gold nanoparticles by Pseudomonas aeruginosa with therapeutical potential in prostate carcinoma". Paper presented in 4th Annual Meeting CINBIO, 2021.
  14. Teixeira, C., Sousa, A. P., Gojon, F., Santos, I., Coelho, A., Baylina, P. and Fernandes, R.. "Caco-2: a model to test the infectivity of SARS-CoV-2". Paper presented in 27th Porto Cancer Meeting i3S, 2021.
  15. Sousa, A. P., Teixeira, C., Santos, I., Gojon, F., Coelho, A., Rigor, J., Mendes, D., Soares, R., Costa, R., Baylina, P.. "Biopotential from antidiabetic drugs - exploiting therapeutical approaches for prostate cancer". Paper presented in 27th Porto Cancer Meeting i3S, 2021.
  16. Sousa, A. P., Franco, C., Cunha, D. M., Baylina, P. and Fernandes, R.. "Unravelling the role of a-hydroxybutyrate in insulin resistance". Paper presented in IJUP’21 – 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  17. Sousa, A. P., Luís, C., Martins-Mendes, D., Rigor, J., Soares, S., Alves, M. G., Soares, R., Baylina, P., Costa, R. and. "Does diabetic secretome encloses the key to fight prostate cancer?". Paper presented in AIMS meeting, 2021.
  18. Sousa, A. P., Lopes, S., Luís, C., Guedes, C., Teixeira, C., Rigor, J., Mendes, D., Costa, R., Duarte, F., Soares, R., B. "Avaliação do potencial anti tumoral de fármacos antidiabéticos em cancro de próstata". Paper presented in 17º Portuguese Diabetes Congress, 2021.
  19. Sousa, A. P., Luís, C., Lopes, S., Guedes, C., Teixeira, C., Rigor, J., Mendes-Martins, D., Costa, R., Soares, R., Bayli. "Efeito da testosterona e estradiol no paradoxo diabetes/cancro de próstata". Paper presented in 17º Portuguese Diabetes Congress, 2021.
  20. Teixeira, C., Guedes, C., Sousa, A. P., Lopes, S., Luís, C., Soares, R., Baylina, P., Moreira, F., Alencastre, I. and Fe. "Alterações morfopatológicas no rim de rato com obesidade e insulino-resistência". Paper presented in 17º Portuguese Diabetes Congress, 2021.
  21. Luís, C., Sousa, A. P., Duarte, M., Teves, F., Fuente, J., Soares, R. and Fernandes, R.. "Níveis elevados de estradiol e testosterona afectam o estímulo resposta imune contra o cancro da próstata". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  22. Sousa, A. P., Luís, C., Rigor, J., Barbosa, J., Martins, D., Costa, R. and Fernandes, R.. "Prostate cancer cell Pc3 behavior under a simulated type 2 diabetic microenvironment". Paper presented in 16º Portuguese Diabetes Congress, 2020.
Journal article
  1. Oliveira, Marco; André P Sousa; Sara Sá; Sílvia Soares; Ana Cláudia Pereira; Ana Catarina Rocha; Patrick Pais; et al. "Harvesting the Power of Green Synthesis: Gold Nanoparticles Tailored for Prostate Cancer Therapy". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25042277.
    10.3390/ijms25042277
  2. Carla Luís; André P. Sousa; Raquel Costa; Ana T. Maduro; Patrick J. Pais; Sara Sá; Álvaro Gestoso; et al. "Exploring the Anti-Cancer Properties of Pomegranate Peel Aqueous Extract". Applied Sciences (2023): https://doi.org/10.3390/app132111773.
    10.3390/app132111773
  3. André Sousa; Ana Catarina Oliveira; Cátia Almeida; Mariana Carneiro; Patrick Pais; Rejane Viana; Rúben Fernandes; et al. "Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic". Applied Sciences (2023): https://www.mdpi.com/2076-3417/13/21/11933.
    10.3390/app132111933
  4. Sílvia Soares; Cláudia Pereira; André P. Sousa; Ana Catarina Oliveira; Maria Goreti Sales; Miguel A. Correa-Duarte; Susana G. Guerreiro; Rúben Fernandes. "Metabolic Disruption of Gold Nanospheres, Nanostars and Nanorods in Human Metastatic Prostate Cancer Cells". Cells (2023): https://doi.org/10.3390/cells12050787.
    10.3390/cells12050787
  5. Teixeira, Catarina; André P Sousa; Rocha, Ana Catarina; Pereira, Ana; Martins-Mendes, Daniela; Baylina Machado, Pilar; Pedro Barata; Fernandes, Ruben. "Enhanced 3T3-L1 Differentiation into Adipocytes by Pioglitazone Pharmacological Activation of Peroxisome Proliferator Activated Receptor-Gamma (PPAR-¿)". Biology (2022):
    Published
  6. Teixeira, C., Sousa, A. P., Santos, I., Rocha, A., Alencastre, I., Pereira, A., Mendes, D., Barata, P., Baylina, P. and. "Enhanced 3T3-L1 differentiation into adipocytes by pioglitazone pharmacological activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma)". Paper under major reviews in MDPI - Biology, ID: biology-1604738, IF = 5.079. (2022):
    Submitted
  7. Sousa, A. P., Costa, R., Alves, M. G., Soares, R., Baylina, P. and Fernandes, R.. "The impact of metabolic syndrome and type 2 diabetes mellitus on prostate cancer". Frontiers in Cell and Developmental Biology (2022): https://doi.org/10.3389/fcell.2022.843458.
    Accepted
  8. Santos, S. R., Barata, P., Charmier, A., Lehmann, I., Rodrigues, S., Melosini, M. M., Pais, P. J., Sousa, A. P., Teixeir. "Cannabidiol and terpenes formulation reducing SARS-CoV2 Infectivity tackling a therapeutic strategy". Frontiers in Immunology 373 (2022): https://doi.org/10.3389/fimmu.2022.841459.
    Open access • Published
  9. Susana Santos; Pedro Barata; Adilia Charmier; Inês Lehmann; Suzilaine Rodrigues; Matteo M Melosini; Pais, Patrick J; et al. "Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy". Frontiers in Immunology 13 (2022): 841459. https://www.frontiersin.org/articles/10.3389/fimmu.2022.841459/full.
  10. André P. Sousa; Diogo M. Cunha; Carolina Franco; Catarina Teixeira; Frantz Gojon; Pilar Baylina; Ruben Fernandes. "Which Role Plays 2-Hydroxybutyric Acid on Insulin Resistance?". Metabolites-MDPI 11 12 (2021): 835-835. https://doi.org/10.3390/metabo11120835.
    Published • 10.3390/metabo11120835
Thesis / Dissertation
  1. "Unraveling prostate cancer paradox - molecular, metabolic, and cytometric mechanisms in type 2 diabetes and metabolic syndrome". Master, Instituto Politécnico do Porto Escola Superior de Saúde, 2021.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/10/04 Sousa, A. P., Soares, R. and Fernandes, R. "Prostate cancer therapy based on PSMA". Fundação AstraZeneca Innovate Competition, iMed Conference 12.0 Lisbon, 2020 Fundação AstraZeneca Innovate Competition, iMed Conference 12.0 Lisbon
Fundação AstraZeneca Innovate Competition (Porto, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/08/01 - 2022/09/30 iLoF internship – Summer internship contest – Polytechnic Institute of Porto Implementation and improvement of photonic detection system; sample preparation and data structuring.
iLoF - Intelligent Lab on Fiber, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/11/30 - 2019/11/30 Scientific nature event, with the participation of 120 registrants, about the degree of Medicinal Biotechnology named “BMeeting”.
Member
 Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/01 - 2023/11/30 Medical Genetics Medical Genetics (Licenciatura) Universidade Fernando Pessoa, Portugal
2022/02/21 - 2022/02/25 Hands-On course on methodologies in angiogenesis. Metabolismo ¿ Biopatologia e Experimentação (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2021/07/19 - 2021/07/23 Hands-On course on methodologies in angiogenesis. Metabolismo ¿ Biopatologia e Experimentação Universidade do Porto Faculdade de Medicina, Portugal

Scientific expedition

Activity description Institution / Organization
2023/07/01 - 2023/12/31 iLoF Service contract Blood sample collection, plasma/PBMC/CSF recovery, and high-throughput sample structure; clinical data acquisition and processing. iLoF - Intelligent Lab on Fiber, Portugal
2022/03/21 - 2022/04/24 "IACOBUS" - research exchange grant Universidade de Vigo Centro de Investigaciones Biomédicas, Spain
Distinctions

Award

2022 Merit student - master degree
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022 Best poster presentation – 1st Conference of the Doctoral Program in Metabolism – Clinical and Experimental
Universidade do Porto Faculdade de Medicina, Portugal

Other distinction

2022 "IACOBUS" research exchange grant
IACOBUS , Spain
2020 Finalist of research competition (top 3)
Fundação AstraZeneca Innovate Competition, iMed Conference 12.0 Lisbon, Portugal