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Inês Rodrigues Lopes graduated in Biochemistry at the University of Coimbra in 2014 and obtained her MSc degree in Biochemistry in 2016 at the University of Porto. Currently, she is a PhD student of the PhD Programme in Experimental Biology and Biomedicine (PDBEB), at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. Inês works in the areas of Microbiology and Cell Biology. Her studies focus on the virulence mechanisms and molecular processes operating in hosts infected with bacterial pathogens with high impact in human health, such as Staphylococcus aureus, Shigella flexneri, Salmonella Typhimurium, Escherichia coli and Group B Streptococcus. She has published 5 papers in peer-reviewed journals, mainly in the area of infectious diseases. During her PhD project, Inês characterized the infection profile of 191 Staphylococcus aureus clinical isolates within various host cell types. This comprehensive study was accomplished by integrating high-content, fluorescence microscopy-based and luminescence-based high-throughput screening approaches which established Staphylococcus aureus intracellular lifestyle as a prevalent feature of infection, with potential implications for the effective treatment of staphylococcal infections (Rodrigues Lopes I, et al., 2022). In addition, Inês screened a genome-wide collection of 1,920 transposon-mapped Staphylococcus aureus mutants (NTML collection), to identify bacterial factors that modulate different stages of Staphylococcus aureus intracellular infection within professional and non-professional phagocytes, to define novel therapeutic approaches.
Identification

Personal identification

Full name
Inês Rodrigues Lopes

Citation names

  • Rodrigues Lopes, Inês
  • Lopes, Inês Rodrigues

Author identifiers

Ciência ID
4517-A68E-1EA0
ORCID iD
0000-0003-1527-543X

Email addresses

  • ines.lopes13ns@gmail.com (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019 - 2022
Ongoing
Experimental Biology and Biomedicine (Doutoramento)
Major in Biotecnologia e Saúde
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
"Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants" (THESIS/DISSERTATION)
2014 - 2016
Concluded
Biochemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Exploring the immunobiological basis of prospective strategies towards two human neonatal pathogens: Group B Streptococcus and Escherichia coli" (THESIS/DISSERTATION)
2010 - 2014
Concluded
Biochemistry (Licenciatura)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Chimeric studies: towards the non-invasive evaluation of renal grafts" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2017/09 - 2018/12 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/08 - 2018/09 Visiting Researcher (Research) Universidade de São Paulo Hospital das Clínicas, Brazil
Universidade de São Paulo Hospital das Clínicas, Brazil
2017/01 - 2017/07 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution
Employer
2019/01 - Current PhD student fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/09 - 2016/12 Master student Fellow Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/01 - 2014/07 Bachelor student Fellow Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal
Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal
Projects

Grant

Designation Funders
2019/01 - Current Staphylococcus aureus intracellular lifestyle: phenotypical profiles and underlying molecular determinants
PD/BD/146464/2019
PhD Student Fellow
Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2022/12 Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Team member
Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/09 - 2018/12 Intracellular Staphylococcus aureus: deciphering bacterial and cellular factors involved in host cell invasion by clinically relevant strains to define new therapeutic approaches (StaphIn)
Infect-ERA/0001/2015
Research Fellow
Centro de Inovação em Biomedicina e Biotecnologia, Portugal
European Commission Seventh Framework Programme for Research and Technological Development Health
Ongoing
2015/09 - 2016/12 Avaliação do impacto de uma nova vacina contra as doenças dos recém-nascidos causadas pelo estreptococos do grupo B na microbiota comensal
POCI-01-0145-FEDER-016607
Master Student Fellow
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Ongoing
Outputs

Publications

Conference poster
  1. Rodrigues Lopes, Inês; Alcantara, Laura Maria ; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena Pedrero ; Cabrerizo, Ana Marina ; Bonhomme, Melanie ; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in EMBO| EMBL Symposium: New Approaches and Concepts in Microbiology, 2023.
  2. Rodrigues Lopes, Inês; Silva, Ricardo Jorge; Josse, Jerome; Vega, Elena P. ; Bonhomme, Melanie ; Lopez, Daniel ; Laurent, Frederic; et al. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in BEB Day 2022- The Overview Effect, 2022.
  3. Rodrigues Lopes, Inês; Silva, Ricardo Jorge; Josse, Jerome ; Vega, Elena P. ; Bonhomme, Melanie ; Lopez, Daniel ; Laurent, Frederic; et al. Corresponding author: Eulalio, Ana. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Paper presented in EMBO| EMBL Symposium: New Approaches and Concepts in Microbiology, 2021.
  4. Cunha, Pedro; Morais, Catarina; Rodrigues Lopes, Inês; Mestre, Beatriz; Jurado, Amália S; Pedroso de Lima, Maria C. "Differentiation therapy toward glioblastoma stem-like cells". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  5. Carvalho, Diana; Marques, Bruno ; Rodrigues Lopes, Inês; Simões, Olivia ; Gomes, José ; Gonçalves, Ana ; Mateus, Rosário; et al. "Potential molecular markers of chronic dysfunction in urine of kidney transplant patients". Paper presented in 29th European Immunogenetics and Histocompatibility Conference, 2015.
Journal article
  1. Rodrigues Lopes, Inês; Alcantara, Laura Maria ; Silva, Ricardo Jorge; Josse, Jerome ; Vega, Elena Pedrero ; Cabrerizo, Ana Marina ; Bonhomme, Melanie ; et al. Corresponding author: Eulalio, Ana. "Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature". Nature Communications 13 7174 (2022):
    Published • 10.1038/s41467-022-34790-9
  2. Aguilar, Carmen; Cruz, Ana Rita; Rodrigues Lopes, Ines; Maudet, Claire; Sunkavalli, Ushasree; Silva, Ricardo Jorge; Sharan, Malvika; et al. Corresponding author: Eulalio, Ana. "Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection". Nature Microbiology 5 1 (2019): 192-205.
    Published • 10.1038/s41564-019-0614-3
  3. Rodrigues Lopes, Ines; Silva, Ricardo Jorge; Caramelo, Ines; Eulalio, Ana; Mano, Miguel. Corresponding author: Mano, Miguel. "Shedding light on microRNA function via microscopy-based screening". Methods 152 (2019): 55-64.
    Published • 10.1016/j.ymeth.2018.09.011
  4. Tawk, Caroline; Nigro, Giulia; Rodrigues Lopes, Ines; Aguilar, Carmen; Lisowski, Clivia; Mano, Miguel; Sansonetti, Philippe; Vogel, Jörg; Eulalio, Ana. Corresponding author: Eulalio, Ana. "Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens". The EMBO Journal 37 23 (2018):
    Published • 10.15252/embj.201798529
  5. Cunha, Pedro P; Costa, Pedro M; Morais, Catarina M; Rodrigues Lopes, Inês; Cardoso, Ana M; Cardoso, Ana L; Mano, Miguel; Jurado, Amália S; Pedroso de Lima, Maria C. "High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors". Human Molecular Genetics 26 22 (2017): 4375-4387.
    Published • 10.1093/hmg/ddx323
Thesis / Dissertation
  1. Lopes, Inês. "Exploring the immunobiological basis of prospective strategies towards two human neonatal pathogens: Group B Streptococcus and Escherichia coli". Master, Universidade do Porto Faculdade de Ciências, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/09 Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature Innovative Therapies Retreat 2022
Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2022/02 Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature High-Throughput Screening for Target and Drug Discovery Course (PDBEB)
University of Coimbra (Coimbra, Portugal)
2021/09 Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature Innovative Therapies Retreat 2021
Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2019/12 Interaction of Staphylococcus aureus with host cells: evaluation of the prevalence of the intracellular lifestyle Microbiotec 19
Sociedade Portuguesa de Microbiologia, Sociedade Portuguesa de Biotecnologia (Coimbra, Portugal)
2016/02 Deciphering the innate immune response of neonates to the pathogen Escherichia coli 9th IJUP | Investigação Jovem da Universidade do Porto
Universidade do Porto (Porto, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2019/12/09 - 2019/12/10 BEBDAY 2019 (2019/12/09 - 2019/12/10)
Conference (Member of the Organising Committee)
Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/02/01 - 2021/02/05 High-Throughput Screening for Target and Drug Discovery Course
Workshop
High-Throughput Screening for Target and Drug Discovery
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/04/01 - 2019/04/05 Host and Microbe Interactions II (Biology at the Host Microbe Interface PHD Program)
Workshop
Host and Microbe Interactions II (Biology at the Host Microbe Interface PHD Program)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/03/18 - 2019/03/22 Fighting Infection Course (PDBEB)
Workshop
Fighting Infection
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/14 - 2017/09/14 High Content Imaging and Complementary Techonologies
Workshop
High Content Imaging and Complementary Techonologies
PerkinElmer Inc, United States
2016/07/15 - 2016/07/15 GABBA Annual Symposium: Breaking Boundaries in Science
Symposium
GABBA Annual Symposium: Breaking Boundaries in Science
Universidade do Porto, Portugal
2014/03/24 - 2014/03/24 Células Estaminais: da investigação básica à aplicação terapêutica
Workshop
Células Estaminais: da investigação básica à aplicação terapêutica
Instituto Português do Sangue e da Transplantação IP, Portugal
2013/06/08 - 2013/06/08 2nd BEB Symposium: Seeding Curiosity, Harvesting Science
Symposium
2nd BEB Symposium: Seeding Curiosity, Harvesting Science
Centro de Inovação em Biomedicina e Biotecnologia, Portugal