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Marta Mesquita is an Anatomical Pathological Technician at the Oncology Institute in Lisbon (IPO) and her main interests are to combine professional activity, the exercise of laboratory functions inherent to anatomopathological diagnosis, with the development of scientific research, namely translational research in oncobiology in order to contribute to the improvement of health care for cancer patients. With this goal in mind, she participated and contributed with her expertise in numerous scientific projects developed by multidisciplinary teams at the cancer institute and in collaboration with research institutes as Gulbenkian Institute of Science (IGC) that resulted in several international publications. She has a PhD in Biomedicine by the university of Beira Interior, whose thesis was focused in Barrett's Esophagus disease. This work brought new insights about the pathways underlying BE malignant progression with the identification of potential biomarkers relevant for the diagnosis, prognosis and management of BE patients thus contributing to an improved understanding of BE biology and an optimized support for clinical decisions. She organized several scientific events and trained several junior scientists. Also, she is regularly invited to give lectures in higher education schools. At present she continues to pursuit her goal of combining her daily job with scientific research.
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Identification

Personal identification

Full name
Marta Catarina Piedade Sirgado Mesquita
Gender
Female

Citation names

  • Sirgado, M
  • Mesquita, M
  • Mesquita, Marta

Author identifiers

Ciência ID
441F-D76D-CC7E
ORCID iD
0000-0003-4738-8949

Email addresses

  • mmesquita@ipolisboa.min-saude.pt (Professional)
  • martamesquita78@gmail.com (Personal)
  • marta-sirgado@hotmail.com (Personal)

Addresses

  • Instituto Português de Oncologia de Lisboa Francisco Gentil. Rua Professor Lima Basto, 1099-023, LISBOA, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Anatomy and mMrphology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2012 - 2020
Concluded
 Biomedicina (Doutoramento)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
 Aprovado com distinção
1996 - 2000
Concluded
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
 17/20
Affiliation

Other Careers

Category
Host institution 		Employer
1999 - 2019 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Anatomia Patológica, Citológica e Tanatológica) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Others

Category
Host institution 		Employer
2022 - Current TSDT Especialista na Área de Anatomia Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2019 - 2022 TSDT na Área de Anatomia Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Projects

Grant

Designation Funders
2009 - 2012 Causes and Consequences of Centrosome and Ploidy Abnormalities in Human Cancer Using Barrett's Esophagus as a Model
HMSP-CT/SAL-ICT/0075/2009
Scientific Initiation Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018 - Current Origin and consequences of centrosome abnormalities in early human tumorigenesis
PDTC/MED-ONC/31565/2017
Researcher
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - Current Caracterização Endoscopico-Histológica da Neo-Junção Esófago-Gástrica após Esofagectomia (Endoscopic and Histologic Characterization of the Neo-Esophagogastric Junction after Esophagectomy)
N/A
Researcher
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Ongoing
2016 - 2018 Depicting Barrett's Esophagus Biopatogenesis and Its Malignant Progression in Three-Dimensional in Vitro Models
N/A
Researcher
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 iNOVA4Health
Concluded
2008 - 2011 Estudos de perda de heterozigotia (LOH) e sequenciação do gene HRPT2 ( Studies of Loss of heterozygosity (LOH) and sequencing of the HRPT2 gene)
N/A
Technical development
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Concluded
2008 - 2010 Estudo das Alterações Centrossómicas e da sua Repercussão Celular no Esófago de Barrett e Adenocarcinoma Associado (Study of Centrosomal Alterations and their consequences in Barrett's Esophagus and Associated Adenocarcinoma)
N/A
Researcher
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Sociedade Portuguesa de Gastroenterologia
Concluded
2008 - 2009 Caracterização das mutações da beta-catenina nos carcimomas pouco diferenciados e indiferenciados da tiróide (Characterization of beta-catenin mutations in poorly differentiated and undifferentiated thyroid carcinomas)
N/A
Technical development
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Concluded
2005 - 2006 Mecanismos de metastização dos carcinomas papilares e foliculares da tiróide (Metastatic mechanisms in papillar and follicular thyroid carcinomas)
N/A
Technical development
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
 Liga Portuguesa Contra o Cancro
Concluded

Other

Designation Funders
2012 - 2015 Esófago de Barrett – Contributos para a Definição do Conceito e para o Conhecimento do Risco de Progressão Neoplásica numa População Portuguesa (Barrett's Esophagus - Contributions to the Conceptual Definition and to the Knowledge about Risk of Neoplastic Progression in a Portuguese Population)
N/A
Researcher
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Concluded
2005 - 2008 Prolactin receptor expression in benign and malignant breast lesions of male and female patients
N/A
Technical development
Concluded
Outputs

Publications

Conference poster
  1. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Corresponding author: Lopes, Carla AM. "Timing and regulation of centrosome amplification in human tumorigenesis". Paper presented in Symposium on Tumor Biology: from basic biology to disease, 2018.
  2. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Corresponding author: Lopes, Carla AM. "Centrosome amplification in human tumorigenesis: where, when and how?". Paper presented in CRUK (Cancer Research UK) Symposium Oesophageal Cancer, 2017.
  3. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Corresponding author: Lopes, Carla AM. "Centrosome Amplification in human cancerigenesis: where, when and how?". Paper presented in EACR (European Association for Cancer Research) Conference Goodbye Flat Biology, 2016.
  4. Lopes, Carla AM; Mesquita, Marta; Bettencourt-Dias, Monica; Chaves, Paula. Corresponding author: Lopes, Carla AM. "p53 loss leads to centrosome number amplification in tumor initiation". Paper presented in 3rd EMBO Conference on Centrosomes and SPBs, 2014.
  5. Mesquita, M. "Unravelling novel mechanisms of Barrett's esophagus progression: Centrosome amplification precedes the onset of invasion". Paper presented in 25th European Congress of Pathology, 2013.
  6. Mesquita, M. "Centrosome abnormalities in Barrett's malignant transformation". Paper presented in One day symposium with Carlos Caldas, 2012.
  7. Mesquita, M. "Centrosome profile in Barrett's esophagus". Paper presented in EMBO Conference on Centrosomes and spindle pole bodies, 2011.
  8. Mesquita, M. "Centrosome profile in Barret's metaplastic epithelium and associated neoplasia: an immunofluorescence study". Paper presented in 1st EMBO Conference on centrosomes and spindle pole bodies, 2008.
  9. Mesquita, M. "Prolactin receptor expression in benign and malignant breast lesions of male and female patients". Paper presented in 20th European Congress of Pathology, 2005.
  10. Mesquita, M. "Equipamentos de Protecção Individual Necessários à Realização de Cortes de Congelação no Criostato em Exame Extemporâneo (Personal Protective Equipment Necessary to Make Cryostat Frozen sections during Extemporaneous Exams)". Paper presented in IV Encontro Nacional das Tecnologias da Saúde, 2003.
Journal article
  1. Marta Mesquita; Hugo Pinto Marques; Cardoso J; Silva S; Neto JL; Gonçalves-Reis M; Proença D; et al. "A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liver Transplantation.". Annals of surgery (2022): https://europepmc.org/articles/PMC9534058.
    10.1097/sla.0000000000005637
  2. Marta Mesquita; da Mata S; Franchi-Mendes T; Sofia Abreu; Filipe B; Morgado S; Mesquita M; et al. "Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures.". Cancers (2021): https://europepmc.org/articles/PMC8465429.
    10.3390/cancers13184695
  3. Lopes, Carla A.M.; Mesquita, Marta; Cunha, Ana Isabel; Cardoso, Joana; Carapeta, Sara; Laranjeira, Cátia; Pinto, António E.; et al. "Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis". Journal of Cell Biology 217 7 (2018): 2353-2363. http://dx.doi.org/10.1083/jcb.201711191.
    10.1083/jcb.201711191
  4. Marteil, Gaëlle; Guerrero, Adan; Vieira, André F.; de Almeida, Bernardo P.; Machado, Pedro; Mendonça, Susana; Mesquita, Marta; et al. "Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-03641-x.
    10.1038/s41467-018-03641-x
  5. Pereira, Filipe; Pereira, Sofia S.; Mesquita, Marta; Morais, Tiago; Costa, Madalena M.; Quelhas, Pedro; Lopes, Carlos; Monteiro, Mariana P.; Leite, Valeriano. "Lymph Node Metastases in Papillary and Medullary Thyroid Carcinoma Are Independent of Intratumoral Lymphatic Vessel Density". European Thyroid Journal 6 2 (2017): 57-64. http://dx.doi.org/10.1159/000457794.
    10.1159/000457794
  6. Cardoso, Joana; Mesquita, Marta; Dias Pereira, António; Bettencourt-Dias, Mónica; Chaves, Paula; Pereira-Leal, José B.. "CYR61 and TAZ Upregulation and Focal Epithelial to Mesenchymal Transition May Be Early Predictors of Barrett's Esophagus Malignant Progression". PLOS ONE 11 9 (2016): e0161967. http://dx.doi.org/10.1371/journal.pone.0161967.
    10.1371/journal.pone.0161967
  7. Cavaco BM; Santos R; Félix A; Carvalho D; Lopes JM; Domingues R; Sirgado M; et al. "Identification of de novo germline mutations in the HRPT2 gene in two apparently sporadic cases with challenging parathyroid tumor diagnoses.". (2011): http://europepmc.org/abstract/med/21360064.
    10.1007/s12022-011-9151-1
  8. Ferreira M; Mesquita M; Quaresma M; André S. "Prolactin receptor expression in gynaecomastia and male breast carcinoma.". (2008): http://europepmc.org/abstract/med/18613925.
    10.1111/j.1365-2559.2008.03059.x
  9. Sancho M; Vieira JM; Casalou C; Mesquita M; Pereira T; Cavaco BM; Dias S; Leite V. "Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.". (2006): http://europepmc.org/abstract/med/17065406.
    10.1677/joe.1.06688
Thesis / Dissertation
  1. Mesquita, M. "Biomarkers in Barrett's esophagus:understanding the disease and supporting clinical decisions.". PhD, Universidade da Beira Interior Faculdade de Ciências da Saúde, 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018 Culturas 3D de Carcinoma Colorretal- uma ferramenta com potencial aplicação em terapêutica dirigida. (3D Cultures of Colorectal Carcinoma - a tool with potential application in targeted therapy). XIX Congresso Técnico de Anatomia Patológica
APTAP (Angra do Heroísmo, Portugal)
2017 CYR61 and TAZ upregulation and focal epithelial to mesenchymal transition may be early predictors of Barrett's esophagus malignant progression. One day symposium with Patrick Tan: Knowns and Unknowns in Gastric Cancer and Other Tumours of the Digestive System
IPATIMUP (Porto)
2012 WWTR1 and CYR61 are early markers of Barrett's esophagus malignant progression 24th European Congress of Pathology
European Society of Pathology (Praga, Czech Republic)
2004 Aplicação prática de cortes de grandes superfícies no carcinoma do colo do útero (Practical application of large sections in cervical carcinoma) VI Congresso Técnico de Anatomia Patológica
(Pombal)
2004 A Postura dos Profissionais de Saúde Perante a Morte (Health Professionals emotional management in the face of Death). I Jornadas de Ciências Sociais e Humanas em Saúde
ESTESL (LISBOA, Portugal)
2002 Uma abordagem da morte (An approach to death). IV Congresso Técnico de Anatomia Patológica
ESTESL (LISBOA, Portugal)
2001 Coloração de Verhoeff: função de cada reagente da solução de trabalho de Verhoeff na coloração das fibras elásticas (Verhoeff staining: function of each reagent in the Verhoeff working solution in the staining of elastic fibers) III Congresso Técnico de Anatomia Patológica
APTAP (Porto, Portugal)
1999 Derrames pleurais metastáticos: Casuística de 1 ano (Metastatic pleural effusions: 1-year series) Simposium de Citologia
ESTESL (LISBOA, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014 - 2014 Moderadora no XV Congresso Técnico de Anatomia Patológica, num painel intitulado: A importância da patologia molecular na decisão das terapias alvo. Chair at the 15th Technical Congress of Pathological Anatomy, in a panel entitled: The importance of molecular pathology in the decision of target therapies. (2014 - 2014)
Congress (Other)
2013/05/17 - 2013/05/19 Membro da comissão organizadora do “XIV Congresso Técnico de Anatomia Patológica” (Member of the organizing committee of the “XIV Technical Congress of Pathological Anatomy”). (2013/05/17 - 2013/05/19)
Congress (President of the Organising Committee)
2010/10/13 - 2010/10/13 Colaboração na organização do “I Curso de Imunocitoquímica e SISH para Citotécnicos”realizado no serviço de Anatomia patológica do HPP Hospital de Cascais. Collaboration in the organization of the “I Course on Immunocytochemistry and SISH for Cytotechnicians” held at the Pathological Anatomy service of the HPP Hospital de Cascais. (2010/10/13 - 2010/10/13)
Other (Co-organisor)
2008/05/16 - 2008/05/18 Membro da comissão organizadora do “X Congresso Técnico de Anatomia Patológica. Member of the organizing committee of the “X Technical Congress of Pathological Anatomy" (2008/05/16 - 2008/05/18)
Congress

Association member

Society Organization name Role
2005 - 2015 Direção Nacional da Associação Portuguesa de Técnicos de Anatomia Patológica (National Board of the Portuguese association for Anatomical Pathological Technicians)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Docente convidada para leccionar o tema: Estudo de fatores genéticos predisponentes para doenças multifatoriais comuns: Cancro Esporádico vs Cancro familiar na Unidade Curricular: Estudo Laboratorial Genético, do 1º ano do Curso de Mestrado em Tecnologias Clinico-Laboratoriais Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2019/11/30 - Current Docente convidada para leccionar o tema: Técnicas Moleculares em Patologia Oncológica na Unidade Curricular: Métodos Laboratoriais Aplicados às doenças Oncológicas, do 1º ano do Curso de Mestrado em Tecnologias Clinico-Laboratoriais (Invited Professor to teach a Seminar about "Molecular Techniques in Oncological Pathology" in the class: Laboratory Methods Applied to Oncological Diseases, 1st year of the Master's degree in Clinical and Laboratory Technologies). Mestrado em Tecnologias Clinico-Laboratoriais (Mestrado) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2019 - Current Docente convidada para leccionar o tema: Procedimento Anatomopatológico para biópsias de medula óssea na Unidade Curricular: Hematologia Laboratorial de Urgência, do 1º ano do Curso de Mestrado em Tecnologias Clinico-Laboratoriais Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015 - Current Docente convidada para leccionar a componente teórica do Seminário de Técnicas Especiais do Modulo de Introdução à Patologia do 3ºano do Mestrado Integrado em Medicina da Faculdade de Ciências da Saúde da Universidade da Beira Interior (Invited Lecturer of the theoretical component of the Special Techniques Seminar of the Introduction to Pathology Module of the 3rd year of the Integrated Master in Medicine at the Faculty of Health Sciences of the University of Beira Interior) Medicina (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2010/10/13 - 2013/10/13 Docente convidada para leccionar o tema: “Técnica Histopatológica para Megafragmentos”- na Escola Superior de Tecnologia da Saúde de Lisboa com a duração de 2 horas (Invited lecturer to teach : “Histopathological Technique for Mega Sections” - at the Escola Superior de Tecnologia da Saúde de Lisboa, with a duration of 2 hours Anatomia Patológica, Citológica e Tanatológica (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
Distinctions

Award

2018 Melhor comunicação oral do evento