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Sara Freitas. Concluiu o Doutoramento em Biologia em 2023 pela Universidade do Porto, Faculdade de Ciências (SFRH/BD/116009/2016), o Mestrado em Toxicologia e Contaminação Ambientais em 2014 pela Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar e Licenciatura em Biologia em 2011 pela Universidade do Porto Faculdade de Ciências. Atualmente é assitente de investigação de Cultura de Microalgas e Bioprocesso no projeto BlueBio4Future (BB4F). É também labmanager no laboratório Cyanobacterial Natural Products (CNP), CIIMAR. Publicou 11 artigos em revistas especializadas. Possui 1 patente(s) registada(s). Participa e/ou participou como Outra em 3 projeto(s). Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia e Biotecnologia. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Produtos Naturais; Cianobactérias ; Biotecnologia; .
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Identification

Personal identification

Full name
Sara Freitas

Citation names

  • Freitas, Sara

Author identifiers

Ciência ID
441F-A480-0725
ORCID iD
0000-0002-3345-4100

Email addresses

  • sfreitas@ciimar.up.pt (Professional)

Telephones

Telephone
  • 223 401 8 Ext.: 70 (Professional)

Addresses

  • CIIMAR-Centro de Interdisciplinar de Investigação Marinha e Ambiental . Avenida General Norton de Matos, S/N, 4450-208, Matosinhos, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2017/09 - 2023/12/13
Concluded
 Biologia (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Discovery of New Chemistry and Enzymology from Cyanobacteria" (THESIS/DISSERTATION)
 Aprovada
2014
Concluded
 Toxicologia e Contaminação Ambientais (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Toxicological Assessment of Marine Cyanobacterial Extracts in Human Cell Lines – Proteomic and Gene Expression Approach" (THESIS/DISSERTATION)
 18
2011
Concluded
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Feeding behavior of the Red Fox, Vulpes vulpes, in Portugal" (THESIS/DISSERTATION)
 13
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2020/10/06 - 2021/02/05 Visiting Professor (University Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2017 - 2022/03/13 PhD Schoolarship Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2014/11/01 - 2015/10/31 Estágio profissional Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2014/07/07 - 2014/07/11 Monitora do programa Ciência Viva no Laboratório - Ocupação Científica de Jovens nas Férias (OCJF) com o título de "Cianobactérias no ataque às células cancerígenas". Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2013 - 2014/01/24 Master Internship Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Projects

Contract

Designation Funders
2022/03/16 - 2025/09/30 BlueBio4Future – Blue Biotechnology and Bioengineering for the Current and Future Development of a Blue Bioeconomy in Portugal
952374
10.3030/952374
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 European Commission
Ongoing

Other

Designation Funders
2020/10 - Current ATLÂNTIDA
NORTE-01-0145-FEDER-000040
Member of research team
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2017 - Current Halversity
PTDC/BIA-BQM/29710/2017
Other
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2016/01/01 - Current BLUEandGREEN Project
692419
Other
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Concluded
Outputs

Publications

Conference poster
  1. Freitas, Sara; Castelo-Branco, Raquel; Wenzel-Storjohann, Arlette; Vasconcelos, Vitor; Leão, Pedro N.; Tasdemir, Deniz. "Discovery of Desmamides A-C, New Lipoglycopeptides from the Endophytic Cyanobacterium Desmonostoc muscorum LEGE 12446". Paper presented in 3rd Synthetic Biology of Natural Products Conference, 2022.
  2. "Molecular Network Guided Isolation of Novel Glycolipopeptides from Desmonostoc muscorum". Paper presented in XII EUROPEAN CONFERENCE ON MARINE NATURAL, 2021.
  3. "GNPS-guided isolation of cyanobacterial secondary metabolites from the lege culture collection". Paper presented in XVI MaNaPro & XI ECMNP, 2019.
  4. "Discovery and characterization of new natural products from promising Cyanobacteria". Paper presented in 30th International Symposium on the Chemistry of Natural Products, 2018.
  5. "Elucidating the Mechanisms Involved in the Cytotoxicity Induced by Marine Cyanobacteria Strains against the RKO Colon Adenocarcinoma Cell Line". Paper presented in 4th Cyanobacteria Iberic Congress, 2015.
  6. "Toxicological Assessment of Marine Cyanobacterial Extracts in Human Cell Lines – Proteomic and Gene Expression Approach". Paper presented in 3rd Cyanobacteria Iberic Congress, 2013.
  7. "Toxicological Assessment of Marine Cyanobacterial Extracts in Human Cell Lines – Proteomic and Gene Expression Approach". Paper presented in 6th Meeting of Young Researchers of University of Porto (IJUP), 2013.
Journal article
  1. Brito, Ângela; Martins, Teresa; Freitas, Sara; Castelo Branco, Raquel; Rego, Adriana; Vasconcelos, Vitor M.; Gerwick, William H.; Tamagnini, Paula; Leão, Pedro N.. "Isolation and Biosynthesis of Hyellamide, a Glycosylated N-Acyltyrosine Derivative, from the Cyanobacterium Hyella patelloides LEGE 07179". Journal of Natural Products 88 3 (2025): 850-856. https://doi.org/10.1021/acs.jnatprod.4c00968.
    10.1021/acs.jnatprod.4c00968
  2. Castelo-Branco, Raquel; Pereira, João P.; Freitas, Sara; Preto, Marco; Vieira, Ana R.; Morais, João; Leão, Pedro N.. "Genome-informed Discovery of Monchicamides A–K: Cyanobactins from the Microcoleaceae Cyanobacterium LEGE 16532". Journal of Natural Products 88 1 (2024): 86-93. https://doi.org/10.1021/acs.jnatprod.4c01063.
    10.1021/acs.jnatprod.4c01063
  3. Reis, João P. A.; Freitas, Sara; Procházková, Tereza; Leão, Pedro N.. "Expanding the Diversity of the Cyanobacterial Dialkylresorcinol Bartoloside Family". Journal of Natural Products 87 12 (2024): 2709-2715. https://doi.org/10.1021/acs.jnatprod.4c00832.
    10.1021/acs.jnatprod.4c00832
  4. Girão, Mariana; Freitas, Sara; Martins, Teresa P.; Urbatzka, Ralph; Carvalho, Maria F.; Leão, Pedro N.. "Decylprodigiosin: a new member of the prodigiosin family isolated from a seaweed-associated Streptomyces". Frontiers in Pharmacology 15 (2024): https://doi.org/10.3389/fphar.2024.1347485.
    10.3389/fphar.2024.1347485
  5. Leão, Pedro N.; Martins, Teresa P.; Abt, Kathleen; Reis, João P. A.; Figueiredo, Sandra; Castelo-Branco, Raquel; Freitas, Sara. "Incorporation and modification of fatty acids in cyanobacterial natural products biosynthesis". Chemical Communications 59 30 (2023): 4436-4446. http://dx.doi.org/10.1039/d3cc00136a.
    10.1039/d3cc00136a
  6. Freitas, Sara; Castelo-Branco, Raquel; Wenzel-Storjohann, Arlette; Vasconcelos, Vitor M.; Tasdemir, Deniz; Leão, Pedro N.. "Structure and Biosynthesis of Desmamides A–C, Lipoglycopeptides from the Endophytic Cyanobacterium Desmonostoc muscorum LEGE 12446". Journal of Natural Products 85 7 (2022): 1704-1714. https://doi.org/10.1021/acs.jnatprod.2c00162.
    10.1021/acs.jnatprod.2c00162
  7. Carrasco del Amor, Ana; Freitas, Sara; Urbatzka, Ralph; Fresnedo, Olatz; Cristobal, Susana. "Application of Bioactive Thermal Proteome Profiling to Decipher the Mechanism of Action of the Lipid Lowering 132-Hydroxy-pheophytin Isolated from a Marine Cyanobacteria". Marine Drugs 17 6 (2019): 371. http://dx.doi.org/10.3390/md17060371.
    Published
  8. Freitas, Sara; Silva, Natália Gonçalves; Sousa, Maria Lígia; Ribeiro, Tiago; Rosa, Filipa; Leão, Pedro N.; Vasconcelos, Vitor; Reis, Mariana Alves; Urbatzka, Ralph. "Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities". Marine Drugs 17 4 (2019): 229. http://dx.doi.org/10.3390/md17040229.
    Published
  9. Martins, Teresa P.; Rouger, Caroline; Glasser, Nathaniel R.; Freitas, Sara; de Fraissinette, Nelly B.; Balskus, Emily P.; Tasdemir, Deniz; Leão, Pedro N.. "Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols". Natural Product Reports 36 10 (2019): 1437-1461. http://dx.doi.org/10.1039/c8np00080h.
    Published • 10.1039/c8np00080h
  10. Urbatzka, Ralph; Freitas, Sara; Palmeira, Andreia; Almeida, Tiago; Moreira, João; Azevedo, Carlos; Afonso, Carlos; et al. "Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives". European Journal of Medicinal Chemistry 151 (2018): 272-284. http://dx.doi.org/10.1016/j.ejmech.2018.03.036.
    Published • 10.1016/j.ejmech.2018.03.036
  11. Noinart, Jidapa; Buttachon, Suradet; Dethoup, Tida; Gales, Luís; Pereira, José; Urbatzka, Ralph; Freitas, Sara; et al. "A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces stipitatus KUFA 0207". Marine Drugs 15 5 (2017): 139. http://dx.doi.org/10.3390/md15050139.
    Published
  12. Costa, M.S.; Rego, A.; Ramos, V.; Afonso, T.B.; Freitas, S.; Preto, M.; Lopes, V.; et al. "The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84961829578&partnerID=MN8TOARS.
    10.1038/srep23436
  13. Afonso, T.B.; Costa, M.S.; Rezende De Castro, R.; Freitas, S.; Silva, A.; Schneider, M.P.C.; Martins, R.; Leão, P.N.. "Bartolosides E-K from a Marine coccoid cyanobacterium". Journal of Natural Products 79 10 (2016): 2504-2513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994005797&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.6b00351
  14. Freitas, S.; Martins, R.; Campos, A.; Azevedo, J.; Osório, H.; Costa, M.; Barros, P.; Vasconcelos, V.; Urbatzka, R.. "Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line". Toxicon 119 (2016): 140-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973482142&partnerID=MN8TOARS.
    10.1016/j.toxicon.2016.05.016
  15. Freitas, S.; Martins, R.; Costa, M.; Leão, P.N.; Vitorino, R.; Vasconcelos, V.; Urbatzka, R.. "Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells". Marine Drugs 14 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989873363&partnerID=MN8TOARS.
    10.3390/md14090158

Intellectual property

Patent
  1. 2019. "Hydroxypheophorbide compounds, methods and uses thereof".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/06 DISCOVERY OF DESMAMIDES A-C, NEW LIPOGLYCOPEPTIDES FROM THE ENDOPHYTIC CYANOBACTERIUM DESMONOSTOC MUSCORUM LEGE 12446 XIII European Congress on Marine Natural Products and XVII International Symposium on Marine Natural Products
(Granada, Spain)
2022/09/09 Discovery of Desmamides A-C, New Lipoglycopeptides from the Endophytic Cyanobacterium Desmonostoc muscorum LEGE 12446 Blue Think Conference
CIIMAR (Matosinhos, Portugal)
2017/06/30 Molecular mechanisms behind the selective cytotoxicity of Hierridin B CIIMAR Seminar
CIIMAR (Matosinhos, Portugal)
2015/07 Mechanisms Involved in the Cytotoxicity of Marine Picocyanobacteria Strains Against the RKO Colon Adenocarcinoma Cell Line 1st International Summer School of Natural Products
(Naples, Italy)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/09/12 - 2023/09/12 International Conference on Marine Biotechnology, BB4F. Registo dos participantes no início da conferência; Organização dos coffee breaks. (2023/09/12 - 2023/09/12)
Conference (Member of the Organising Committee)
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Distinctions

Award

2023 ORAL COMMUNICATION AWARD in XVII MaNaPro & XIII ECMP
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Spain
2022 BIOCHEMISTRY AND BIOTECHNOLOGY best oral presentation
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal