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Belém Sampaio Marques graduated in Biology from the University of the Azores in 2003 and obtained a Ph.D. in Health Sciences from the University of Minho in 2012. Between 2013 and 2019, she developed postdoctoral studies on the study and elucidation of mechanisms related to aging and age-related diseases, using the yeast Saccharomyces cerevisiae as a model for neurodegenerative diseases, namely Parkinson¿s disease. Since 2019, she has been working as a Junior Researcher at ICVS and also serves as an Assistant Professor at the School of Medicine, University of Minho. Her research focuses on elucidating the molecular mechanisms and cellular processes of aging and age-related diseases. As of June 2023, she has shifted her research focus towards developing models to study Parkinson¿s disease and exploring the role of the secretome of mesenchymal stem cells (MSCs) in neuroprotection and repair. Her track record is currently mirrored by 48 publications in international peer-reviewed journals (>2400 citations and h-index=20, Scopus; January 2024), and 2 book chapter. She supervised 1 PhD and 7 MSc thesis. She has been an ad-hoc reviewer for more than 20 journals and some funding agencies. She is also review editor from Stem Cell Research - Frontiers in Cell and Developmental Biology. Belém has been a project reviewer for the National Science Centre (NCN), Poland and Graduate Women in Science (GWIS). Belém received 5 awards and/or honors.
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Identification

Personal identification

Full name
Belém Sampaio Marques

Citation names

  • Sampaio-Marques, B

Author identifiers

Ciência ID
441F-52DC-EBE4
ORCID iD
0000-0001-6580-0971
Researcher Id
M-4758-2013
Scopus Author Id
16204129000

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Beginner (A1) Beginner (A1) Intermediate (B1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2012
Concluded
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"The emerging role of autophagy/mitophagy in a-synuclein-induced toxicity: studies on the yeast chronological aging model" (THESIS/DISSERTATION)
 Approved
2003
Concluded
 Licenciatura em Biologia no ramo de Biologia Aplicada (Licenciatura)
Universidade dos Açores, Portugal
"Hidrolases Extracelulares de um fungo Entomopatogénico (Entomophthorales: Entomophthoraceae ): Determinantes Indutores em cultura" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/02/01 - Current Contracted Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2014/09/01 - Current Assistant (University Teacher) Universidade do Minho - Escola de Medicina, Portugal

Others

Category
Host institution 		Employer
2013/03/01 - 2019/01/31 Post-Doctoral Fellowship (SFRH/BPD/90533/2012) Laboratório Associado ICVS 3B's, Portugal
2008/05/01 - 2012/10/30 PhD student (SFRH/BD/41674/2007) Laboratório Associado ICVS 3B's, Portugal
2005/05/01 - 2008/04/30 Researcher (SFRH/BI/15406/2005) Laboratório Associado ICVS 3B's, Portugal
2004/09/01 - 2005/07/30 Postgraduation Universidade Católica- Escola Superior de Biotecnologia, Portugal
2002/09/01 - 2003/02/28 Internship Universidade dos Açores Departamento de Biologia, Portugal
Projects

Grant

Designation Funders
2021/01/01 - 2025/12/31 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
LA/P/0050/2020
10.54499/LA/P/0050/2020
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/20 - 2025/02/19 Grant
DL 57/2016/CP1377/CT0072
10.54499/DL57/2016/CP1377/CT0072
Researcher
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Immunometabolic requirements in Buruli Ulcer
2022.05266.PTDC
Researcher
Fundação para a Ciência e a Tecnologia
2022/02/01 - 2023/05/31 Extracellular Vesicles as Potential Biomarkers in Fabry disease Progression
Amicus_PL_2021
Amicus_PL_2021
Researcher
Laboratório Associado ICVS 3B's, Portugal
 Amicus Therapeutics Inc
Ongoing
2020/04/01 - 2022/09/30 Reinforcing the response to COVID-19 pandemic by improving diagnostic tools and capacity.
NORTE-01-0145-FEDER-072555
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/16 - 2021/07/15 Innovative Microfluidic Platform for Analysis of myeloid Leukemia blasts mielóide
PTDC/EMD-EMD/30782/2017
POCI-01-0145-FEDER-030782
Researcher
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2021/06/30 Biomimetic microenvironment for the study and development of targeted therapies in hematological malignancies
PTDC/EMD-EMD/28159/2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2020/06/01 - 2020/09/30 Develop fast, highly accurate, low-cost PCR-based protocol to test SARS-CoV-2
208_596865986
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2019/02/19 REGULATION OF AUTOPHAGY DURING AGING: A ROLE FOR YEAST AMPK SNF1 IN RESPONSE TO DNA REPLICATION STRESS
SFRH/BPD/90533/2012
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 Personalized NOS - NORTE-01-0145-FEDER-000013
NORTE-01-0145-FEDER-000013
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016/09/01 - 2017/08/31 Acute myeloid leukemia and human adipose stromal/stem cell-derived cell sheets: exploring the niche contribution for AML malignancy.
ICVS
Principal investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Laboratório Associado ICVS 3B's
Concluded
2011/01 - 2014/06 Study on the relationship between aging and autophagy in yeast Saccharomyces cerevisiae
Provided by PTCRIS: 114116
PTDC/BIA-MIC/114116/2009
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/05/01 - 2012/10/31 YEAST MODELS OF NEURODEGENERATIVE DISEASES: PROTEIN MISFOLDING AND CELL DEATH
SFRH/BD/41674/2007
 Fundação para a Ciência e a Tecnologia
Concluded
2005/05/01 - 2008/04/30 MICOLOGIA CELULAR E MOLECULAR: EPIDEMIOLOGIA DE MICOSES SISTEMÁTICAS E AVALIAÇÃO DE FACTORES DE RISCO
SFRH/BI/15406/2005
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Sampaio-Marques, Belém; Burhans, William C.; Ludovico, Paula. "Yeast at the Forefront of Research on Ageing and Age-Related Diseases". In Progress in Molecular and Subcellular Biology, 217-242. Springer International Publishing, 2019.
    10.1007/978-3-030-13035-0_9
  2. Sampaio-Marques, Belém; Almeida, Bruno; Maciel, Patrícia; Ludovico, Paula. "Protein misfolding and cell death". In Protein Misfolding in Biology and Disease, edited by Tiago outeiro. Kerala, India: Transworld Research Network, 2008.
    Published
Conference poster
  1. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Detecção não invasiva de doença residual mínima em leucemia mielóide aguda usando um sistema de microfluídica para o isolamento e concentração de blastos leucémicos em sangue periférico ou em médula óssea". Paper presented in 3º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2021.
  2. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Isolation and concentration of acute myeloid leukemia blasts in measurable residual disease using a microfluidic system". Paper presented in NanoPT2021 (online), 2021.
  3. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Isolation of Acute Myeloid Leukemia Blasts Using a Microfluidic System for Accurate Assessment of Minimal Residual Disease". Paper presented in EuroNanoForum (online), 2021.
  4. Teixeira, Alexandra; Abalde-Cela, Sara; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; Ludovico, Paula; Diéguez, Lorena. "Desenvolvimento de uma plataforma de microfluídica para diagnóstico e monitorização de doença residual mínima em leucemia mielóide aguda". Paper presented in 2º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2020.
  5. Silva, Helena; Castro, Isabel; Sousa, Rafael; Sousa, Hugo; Sampaio-Marques, Belém; LUDOVICO, PAULA. "INTEGRATION OF LIPID METABOLISM WITH KREBS CYCLE IN ACUTE MYELOID LEUKEMIA§". Paper presented in ISCAM, 2019.
  6. Sousa, Hugo; Sampaio-Marques, Belém; Fernandes , Angela; Castro, Isabel; Sanz-Perez, Juan; LUDOVICO, PAULA. "CLINICAL IMPLICATIONS OF THE AUTOPHAGY CORE GENE VARIATIONS IN ACUTE MYELOID LEUKEMIA". Paper presented in ISCAM 2019, 2019.
  7. Teixeira, Alexandra; Oliveira, Kevin; Abalde-Cela, Sara; Sampaio-Marques, Belém; LUDOVICO, PAULA; Diéguez, Lorena. "A microfluidics platform for the SERS-based detection of acute myeloid leukemia". Paper presented in NanoMed Europe (NME), 2019.
  8. Pereira, H; Sampaio-Marques, B; Ludovico, P.. "Uncovering the molecular mechanisms that tie autophagy and UPS during ageing". Paper presented in 11th Symposium on Metabolism,, 2019.
  9. Pereira, Hélder; Teixeira, Alexandra; Sampaio-Marques, Belém; LUDOVICO, PAULA. "Messenger molecules modulating yeast chronological aging". Paper presented in International Meeting on Yeast Ageing and apoptosis (IMYA), 2018.
  10. Teixeira, Alexandra; Pereira, Olga; Fernandes, Sara; Sampaio-Marques, Belém; Castro, Isabel; LUDOVICO, PAULA. "Interplay between glutaminolysis and autophagy in acute myeloid leukemia cells". Paper presented in 1st Meeting on Vesicular Biology, 2018.
  11. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Interplay between energetic metabolism and autophagic regulation in acute myeloid leukemia cells". Paper presented in 1st Meeting on Vesicular Biology, 2018.
  12. Sampaio-Marques, B; Pereira, H; Ludovico, P.. "Caloric restriction alleviates a-synuclein toxicity in aged yeast cells through regulation of proteolytic systems". Paper presented in 13th International Meeting on Yeast Ageing and Apoptosis (IMYA 13), 2018.
  13. Ana Rita Santos; Hélder Pereira; Belém Sampaio-Marques ; Paula Ludovico. "Effects of charged side chain amino acids supplementation on a- synuclein-mediated toxicity". Paper presented in 1st Meeting on Vesicular Biology, 2018.
  14. Hélder Pereira; Ana Rita Santos; Belém Sampaio-Marques ; Paula Ludovico. "Caloric restriction coordinately balances the proteolytic systems activity during aging of yeast cells expressing alpha-synuclein.". Paper presented in 1st Meeting on Vesicular Biology, 2018.
  15. Teixeira, Alexandra; Pereira, Olga; Mesquita, Ângela; Fernandes, Sara; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Glutaminolysis and autophagy interplay in acute myeloid leukemia cells". Paper presented in ESH 4th International Conference on Acute Myeloid Leukemia ¿Molecular and Translational¿: Advances in Biology and Treatment, 2017.
  16. Pereira, Olga; Fernandes, Sara; Teixeira, Alexandra; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Metabolic cell signalling pathways and autophagy regulation in acute myeloid leukemia cells". Paper presented in ESH 4th International Conference on Acute Myeloid Leukemia ¿Molecular and Translational¿: Advances in Biology and Treatment, 2017.
  17. Fernandes, Sara; Pereira, Olga; Teixeira, Alexandra; Mesquita, Ângela; Fernandes, Ângela; Sampaio-Marques, Belém; Castro, Isabel; et al. "Cell signaling pathways and autophagy regulation in acute myeloid leukemia". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  18. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Energy metabolism in acute myeloid leukemia cells". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  19. Sampaio-Marques, B.; Guimarães J ; Ludovico P. "Coordinate regulation of autophagy and proteasome mediates chronological lifespan extension by caloric restriction". Paper presented in 12th IMYA, 2017.
  20. Fernandes A; Barros P; Afonso AR; Sampaio-Marques, B.; Silva P; Cerveira N; Bizarro S; et al. "Functioning of autophagy on acute myeloid leukemia patients". Paper presented in 3rd PROTEOSTASIS MEETING, 2016.
  21. Fernandes A; Barros P; Afonso AR; Sampaio-Marques, B.; Silva P; Cerveira N; Bizarro S; et al. "Proteolytic systems function on acute myeloid leukemia patients: relation with metabolic disorders". Paper presented in XIX National Congress of Biochemistry (SPB2016), 2016.
  22. Fernandes A; Azevedo M; Pereira O; Sampaio-Marques, B.; Paiva A; Correia-Neves M; Castro I; Ludovico P. "Proteolytic systems as important targets of acute myeloid leukemia therapeutic approaches". Paper presented in Porto Cancer Meeting, 2015.
  23. Sampaio-Marques, B.; Guedes A; Ludovico P. "The TOR pathway and Sirtuin 2 collaborate in the regulation of autophagy of caloric restricted aged cells". Paper presented in IMYA X, 2014.
  24. Sampaio-Marques, B.; Guedes A; Vasilevskiy I; Ludovico P. "Transcriptional regulation of autophagy during yeast chronological aging by nutrient-sensing players". Paper presented in MICROBIOTEC'13, 2013.
  25. Sampaio-Marques, B.; Ludovico P. "Caloric restriction regulates autophagy in yeast aged cells in response to proteotoxicity". Paper presented in 9th IMYA – International Meeting on Yeast Apoptosis, 2012.
  26. Sampaio-Marques, B.; Felgueiras C; Silva A; Rodrigues M; Tenreiro S; Franssens V; Reichert AS; et al. "Alpha-synuclein-induced toxicity is dependent on Sir2-mediated mitophagy in yeast aged cells". Paper presented in 6th International Symposium on Autophagy, 2012.
  27. Silva, A.; Sampaio-Marques, B.; Santos, M. ; Ludovico, P.. "HSP90: endogenous modulators of yeast acetic acid-induced apoptotic cell death". Paper presented in Microbiotec'11, 2011.
  28. Sampaio-Marques, B.; Felgueiras C; Silva A; Ludovico P. "Mitophagy is contributing to alpha-synuclein, wild- type and A53T mutant form, toxicity in aged cells". Paper presented in Microbitec'11, 2011.
  29. Silva A; Sampaio-Marques, B; Ludovico P. "The role of HSP90 in yeast acetic acid-induced apoptosis". Paper presented in 8th International Meeting on yeast Apoptosis, 2011.
  30. Sampaio-Marques, B; Silva A; Ludovico P. "Heterologous expression of the expanded form of ataxin-3 induces cell death in yeast". Paper presented in 8th International Meeting on yeast Apoptosis, 2011.
  31. Sampaio-Marques, B; Rodrigues M; Silva A; Ludovico P. "Heterologous expression of alpha-synuclein, wild-type and A53T mutant form, induces autophagy in yeast". Paper presented in Autophagy (40th keystone symposia season meeting), 2011.
  32. Marques H; Silva A; Sampaio-Marques, B; Ludovico P. "Aconitase as target of degradation during oxidative stress induced apoptosis in Saccharomyces cerevisiae". Paper presented in Microbiotec 09, 2009.
  33. Almeida AJ; Xavier S; Cunha C; Sampaio-Marques, B; Ludovico P; Rodrigues F. "Expression of the Paracoccidioides brasiliensis CDC42 homolog in Saccharomyces cerevisiae triggers a multiple budding phenotype". Paper presented in Microbiotec 09, 2009.
  34. Almeida AJ; Cunha C; Carmona J; Sampaio-Marques, B; Carvalho A; Malavazi I; Steensma Y; et al. "Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis". Paper presented in Microbiotec 09, 2009.
  35. Osorio NS; Sampaio-Marques, B; Pearce DA; Oliveira R; Laranjinha J; Sousa N; Rodrigues F. "Studying the role of nitric oxide in the pathological mechanism of Batten disease". Paper presented in 33rd FEBS Congress and 11th IUBMB Conference, 2008.
  36. Almeida AJ; Cunha C; Sampaio-Marques, B; Carmona JA; Carvalho A; Logarinho E; Leão C; et al. "Singular yeast cell morphology of Paracoccidioides brasiliensis is associated to virulence: down-regulation of the CDC42 homolog". Paper presented in 33rd FEBS Congress and 11th IUBMB Conference, 2008.
  37. Almeida B; Sampaio-Marques, B; Silva A; Ludovico P. "Deletion of HBN1 results in yeast aberrant mitochondrial morphology and chronological life span extension". Paper presented in International Symposium on Mitochondrial Physiology and Pathology IUBMB Symposium, 2008.
  38. Almeida B; Silva A; Mesquita A; Sampaio-Marques, B; Leão C; Rodrigues F; Ludovico P. "Glyceraldehyde-3- phosphate dehydrogenase as a crucial mediator of Saccharomyces cerevisiae apoptotic cell death". Paper presented in 6th IMYA – International Meeting on Yeast Apoptosis, 2008.
  39. Sampaio-Marques, B.; Rodrigues F; Ludovico P; Leão C. "Suvival/Death of Saccharomyces cerevisiae stationary phase cells: nutrients effect". Paper presented in XXV Small Meeting on Yeast Transport and Energetics, 2007.
  40. Almeida B; Buttner S; Ohlmeier S; Silva A; Mesquita A; Sampaio-Marques, B; Osório N; et al. "Evidence for NO-mediated apoptosis in yeast". Paper presented in XIII International Conference on Yeast Genetics and Molecular Biology, 2007.
  41. Almeida AJ; Cunha C; Sampaio-Marques, B; Ludovico P; Leão C; Rodrigues F; Carvalho A; Carmona JA. "Molecular bases for Paracoccidioides brasiliensis multiple budding cellular division: a role for the small Rho-like GTPase Cdc42p". Paper presented in XLI Congress of the Portuguese Society for Microscopy, 2007.
  42. Gomes P; Sampaio-Marques, B; Ludovico P; Rodrigues F; Leão C. "Essential amino acids determine lifespan in yeast". Paper presented in 46th Annual Meeting of the American Society for Cell Biology, 2006.
  43. Gomes P; Sampaio-Marques, B; Ludovico P; Rodrigues F; Leão C. "Essential amino acid supplementation of auxotrophic yeast strains determines lifespan and oxidative stress resistance". Paper presented in XVth National Congress of Biochesmestry, 2006.
Journal article
  1. Pinho, Tiffany S.; Cibrão, Jorge Ribeiro; Silva, Deolinda; Barata-Antunes, Sandra; Campos, Jonas; Afonso, João L.; Sampaio-Marques, Belém; et al. "In vitro neuronal and glial response to magnetically stimulated piezoelectric poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)/cobalt ferrite (CFO) microspheres". Biomaterials Advances 159 (2024): 213798. http://dx.doi.org/10.1016/j.bioadv.2024.213798.
    10.1016/j.bioadv.2024.213798
  2. Marques, Cláudia Raquel; Campos, Jonas; Sampaio-Marques, Belém; Antunes, Filipa Ferreira; dos Santos Cunha, Raquel Medina; Silva, Deolinda; Antunes, Sandra Barata; et al. "Secretome of Bone Marrow Mesenchymal Stromal Cells Cultured in a Dynamic System Induces Neuroprotection and Modulates Microglial Responsiveness in an a-Synuclein Overexpression Rat Model". Cytotherapy (2024): http://dx.doi.org/10.1016/j.jcyt.2024.02.008.
    10.1016/j.jcyt.2024.02.008
  3. Ana Silva; Ana Félix; Mónica Cerqueira; Céline S. Gonçalves; Sampaio-Marques, Belém; Adhemar Longatto-Filho; Fátima Baltazar; Julieta Afonso. "Effects of Lactate Transport Inhibition by AZD3965 in Muscle-Invasive Urothelial Bladder Cancer". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15122688.
    10.3390/pharmaceutics15122688
  4. Marco Caligaris; Sampaio-Marques, Belém; Riko Hatakeyama; Benjamin Pillet; Ludovico P; Claudio De Virgilio; Joris Winderickx; Raffaele Nicastro. "The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses". Journal of Fungi (2023): https://www.mdpi.com/2309-608X/9/8/787.
    10.3390/jof9080787
  5. Ana Inês Silva; Manuel Direito; Pinto-Ribeiro, Filipa; LUDOVICO, PAULA; Belém Sampaio-Marques ; Filipa Pinto-Ribeiro; Ludovico P; Sampaio-Marques, B.. Corresponding author: Belém Sampaio-Marques . "Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: a Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders". Journal of Clinical Medicine (2023): https://www.mdpi.com/2077-0383/12/11/3699.
    Under revision • 10.3390/jcm12113699
  6. Esther Clavero; Jose Manuel Sánchez Maldonado; Angelica Macauda; Rob Ter Horst; Sampaio-Marques, B.; Artur Jurczyszyn; Alyssa Clay-Gilmour; et al. "Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/10/8500.
    10.3390/ijms24108500
  7. Marie-Anne Deprez; Marco Caligaris; Joëlle Rosseels; Riko Hatakeyama; Ruben Ghillebert; Sampaio-Marques, Belém; Kaivalya Mudholkar; et al. "The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1". PLOS Genetics 19 2 (2023): e1010641-e1010641. http://dx.doi.org/10.1371/journal.pgen.1010641.
    10.1371/journal.pgen.1010641
  8. Alexandra Teixeira; Luís Carreira; Sara Abalde-Cela; Sampaio-Marques, Belém; Anabela C. Areias; Ludovico P; L. Diéguez. "Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review". Cancers (2023): https://www.mdpi.com/2072-6694/15/5/1362.
    10.3390/cancers15051362
  9. Farida Tripodi; Ermelinda Falletta; Manuela Leri; Cristina Angeloni; Daniela Beghelli; Laura Giusti; Riccardo Milanesi; et al. "Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts". Nutrients (2022): https://www.mdpi.com/2072-6643/14/20/4368.
    10.3390/nu14204368
  10. Marques, Fernanda; Pinto, Luísa; Azevedo, Maria Manuel; Sampaio-Marques, Belém; Areias, Anabela C.; Salgueira, Ana; Costa, Manuel Joao; Rodrigues, Fernando; Ludovico, Paula. Corresponding author: Ludovico, Paula. "Innovative, integrative, and interactive in-class activity on metabolic regulation: Evaluating educational impacts". Biochemistry and Molecular Biology Education 49 6 (2021): 870-881. http://dx.doi.org/10.1002/bmb.21569.
    10.1002/bmb.21569
  11. Sainz, Juan; García-Verdejo, Francisco José; Martínez-Bueno, Manuel; Kumar, Abhishek; Sánchez-Maldonado, José Manuel; Díez-Villanueva, Anna; Vodicková, Ludmila; et al. "Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts". Cancers 13 6 (2021): 1258. http://dx.doi.org/10.3390/cancers13061258.
    10.3390/cancers13061258
  12. Isabel Castro*; Sampaio-Marques, Belém*; Anabela Areias*; Sousa, H; Ângela Fernandes; José Manuel Sanchez-Maldonado; Cristina Cunha; et al. "Functional Genetic Variants in ATG10 Are Associated with Acute Myeloid Leukemia". Cancers (2021): https://www.mdpi.com/2072-6694/13/6/1344. * Authors contributed equally to the work.
    10.3390/cancers13061344
  13. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  14. Struyfs, Caroline; Cools, Tanne L.; De Cremer, Kaat; Sampaio-Marques, Belém; Ludovico, Paula; Wasko, Brian M.; Kaeberlein, Matt; Cammue, Bruno P.A.; Thevissen, Karin. "The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast". Biochimica et Biophysica Acta (BBA) - Biomembranes 1862 8 (2020): 183255. http://dx.doi.org/10.1016/j.bbamem.2020.183255.
    10.1016/j.bbamem.2020.183255
  15. Oliveira-Pinto, Sofia; Pontes, Olívia; Lopes, Diogo; Sampaio-Marques, Belém; Costa, Marta D.; Carvalho, Luísa; Gonçalves, Céline S.; et al. "Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment". Bioorganic Chemistry 100 (2020): 103942. http://dx.doi.org/10.1016/j.bioorg.2020.103942.
    10.1016/j.bioorg.2020.103942
  16. Lemos, Sílvia; Sampaio-Marques, Belém; Ludovico, Paula; Gaivão, Isabel; Palmeira, Carlos; Martins, Gabriela; Peixoto, Francisco; Pinto-Leite, Rosário; Oliveira, Paula. "Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line". Anti-Cancer Drugs 31 5 (2020): 507-517. http://dx.doi.org/10.1097/cad.0000000000000901.
    10.1097/cad.0000000000000901
  17. Humbert, Magali; Morán, María; de la Cruz-Ojeda, Patricia; Muntané, Jordi; Wiedmer, Tabea; Apostolova, Nadezda; McKenna, Sharon L.; et al. "Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot". Biology 9 3 (2020): 59. http://dx.doi.org/10.3390/biology9030059.
    10.3390/biology9030059
  18. Lage, Patrícia; Sampaio-Marques, Belém; Ludovico, Paula; Mira, Nuno P.; Mendes-Ferreira, Ana. "Transcriptomic and chemogenomic analyses unveil the essential role of Com2-regulon in response and tolerance of Saccharomyces cerevisiae to stress induced by sulfur dioxide". Microbial Cell 6 11 (2019): 509-523. http://dx.doi.org/10.15698/mic2019.11.697.
    10.15698/mic2019.11.697
  19. Castro, Isabel; Sampaio-Marques, Belém; Ludovico, Paula. "Targeting Metabolic Reprogramming in Acute Myeloid Leukemia". Cells 8 9 (2019): 967. http://dx.doi.org/10.3390/cells8090967.
    10.3390/cells8090967
  20. Sampaio-Marques, Belém; Guedes, Ana; Vasilevskiy, Igor; Gonçalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell 18 4 (2019): http://dx.doi.org/10.1111/acel.12922.
    10.1111/acel.12922
  21. Sampaio-Marques, Belém*; Pereira, Hélder*; Santos, Ana R.; Teixeira, Alexandra; Ludovico, Paula. "Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis". Aging 10 12 (2018): 3821-3833. http://dx.doi.org/10.18632/aging.101675. * Authors contributed equally to the work.
    10.18632/aging.101675
  22. Silva, Joana Margarida; Rodrigues, Sara; Sampaio-Marques, Belém; Gomes, Patrícia; Neves-Carvalho, Andreia; Dioli, Chrysoula; Soares-Cunha, Carina; et al. "Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology". Cell Death & Differentiation 26 8 (2018): 1411-1427. http://dx.doi.org/10.1038/s41418-018-0217-1.
    10.1038/s41418-018-0217-1
  23. Pontes, Olívia; Costa, Marta; Santos, Filipa; Sampaio-Marques, Belém; Dias, Tatiana; Ludovico, Paula; Baltazar, Fátima; Proença, Fernanda. "Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment". European Journal of Medicinal Chemistry 157 (2018): 101-114. http://dx.doi.org/10.1016/j.ejmech.2018.07.058.
    10.1016/j.ejmech.2018.07.058
  24. Pereira, Olga; Teixeira, Alexandra; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; Ludovico, Paula. "Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells". Journal of Cellular and Molecular Medicine 22 10 (2018): 4807-4817. http://dx.doi.org/10.1111/jcmm.13737.
    10.1111/jcmm.13737
  25. Sampaio-Marques, Belém; Ludovico, Paula. "Linking cellular proteostasis to yeast longevity". FEMS Yeast Research 18 5 (2018): http://dx.doi.org/10.1093/femsyr/foy043.
    10.1093/femsyr/foy043
  26. Costa, Marina; Cerqueira, Mariana T.; Santos, Tírcia C.; Sampaio-Marques, Belém; Ludovico, Paula; Marques, Alexandra P.; Pirraco, Rogério P.; Reis, Rui L.. "Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy". Acta Biomaterialia 55 (2017): 131-143. http://dx.doi.org/10.1016/j.actbio.2017.03.034.
    10.1016/j.actbio.2017.03.034
  27. Ferreira, A C; Santos, T; Sampaio-Marques, B; Novais, A; Mesquita, S D; Ludovico, P; Bernardino, L; et al. "Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours". Molecular Psychiatry 23 4 (2017): 1031-1039. http://dx.doi.org/10.1038/mp.2017.95.
    10.1038/mp.2017.95
  28. Guedes, Ana; Ludovico, Paula; Sampaio-Marques, Belém. "Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy". Mechanisms of Ageing and Development 161 (2017): 270-276. http://dx.doi.org/10.1016/j.mad.2016.04.006.
    10.1016/j.mad.2016.04.006
  29. Vriens, Kim; Kumar, Phalguni Tewari; Struyfs, Caroline; Cools, Tanne L.; Spincemaille, Pieter; Kokalj, Tadej; Sampaio-Marques, Belém; et al. "Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway". Oxidative Medicine and Cellular Longevity 2017 (2017): 1-17. http://dx.doi.org/10.1155/2017/4064628.
    10.1155/2017/4064628
  30. Guerreiro, Joana; Sampaio-Marques, Belém; Soares, Renata; Coelho, Ana; Leao, Cecilia; Ludovico, Paula; Sa-Correia, Isabel. "Mitochondrial proteomics of the acetic acid - induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii - derived hybrid strain". Microbial Cell 3 2 (2016): 65-78. http://dx.doi.org/10.15698/mic2016.02.477.
    10.15698/mic2016.02.477
  31. Mesquita, I.; Moreira, D.; Sampaio-Marques, B.; Laforge, M.; Cordeiro-da-Silva, A.; Ludovico, P.; Estaquier, J.; Silvestre, R.. "AMPK in Pathogens". EXS 107 (2016): 287-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021851263&partnerID=MN8TOARS.
  32. Sampaio-Marques, Belém; Ludovico, Paula. "Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies". Biomolecules 5 2 (2015): 735-757. http://dx.doi.org/10.3390/biom5020735.
    10.3390/biom5020735
  33. Fernandes Â; Azevedo MM; Pereira O; Sampaio-Marques, B; Paiva A; Correia-Neves M; Castro I; et al. "Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.". Oncotarget 6 31 (2014): 31428-31440. http://europepmc.org/abstract/med/25537507.
    10.18632/oncotarget.2947
  34. Gama, José B.; Ohlmeier, Steffen; Martins, Teresa G.; Fraga, Alexandra G.; Sampaio-Marques, B.; Carvalho, Maria A.; Proença, Fernanda; et al. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen". PLoS Neglected Tropical Diseases 8 8 (2014): e3066. http://dx.doi.org/10.1371/journal.pntd.0003066.
    10.1371/journal.pntd.0003066
  35. Barros, Alexandre A.; Rita, Ana; Duarte, C.; Pires, Ricardo A.; Sampaio-Marques, Belém; Ludovico, Paula; Lima, Estevão; Mano, João F.; Reis, Rui L.. "Bioresorbable ureteral stents from natural origin polymers". Journal of Biomedical Materials Research Part B: Applied Biomaterials 103 3 (2014): 608-617. http://dx.doi.org/10.1002/jbm.b.33237.
    10.1002/jbm.b.33237
  36. Sampaio-Marques, Belém; Burhans, William; Ludovico, Paula. "Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing". Microbial Cell 1 4 (2014): 118-127. http://dx.doi.org/10.15698/mic2014.04.136.
    10.15698/mic2014.04.136
  37. Silva, Alexandra; Sampaio-Marques, Belém; Fernandes, Ângela; Carreto, Laura; Rodrigues, Fernando; Holcik, Martin; Santos, Manuel A. S.; Ludovico, Paula. "Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid". PLoS ONE 8 8 (2013): e71294. http://dx.doi.org/10.1371/journal.pone.0071294.
    10.1371/journal.pone.0071294
  38. Weinberger, Martin; Sampaio-Marques, Belém; Ludovico, Paula; Burhans, William C.. "DNA replication stress-induced loss of reproductive capacity inS. cerevisiaeand its inhibition by caloric restriction". Cell Cycle 12 8 (2013): 1189-1200. http://dx.doi.org/10.4161/cc.24232.
    10.4161/cc.24232
  39. Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy 8 10 (2012): 1494-1509. http://dx.doi.org/10.4161/auto.21275.
    10.4161/auto.21275
  40. Costa-de-Oliveira, Sofia; Sampaio-Marques, Belém; Barbosa, Matilde; Ricardo, Elisabete; Pina-Vaz, Cidália; Ludovico, Paula; Rodrigues, Acácio G.. "An alternative respiratory pathway on Candida krusei: implications on susceptibility profile and oxidative stress". FEMS Yeast Research 12 4 (2012): 423-429. http://dx.doi.org/10.1111/j.1567-1364.2012.00789.x.
    10.1111/j.1567-1364.2012.00789.x
  41. Silva, A.; Almeida, B.; Sampaio-Marques, B.; Reis, M.I.R.; Ohlmeier, S.; Rodrigues, F.; Vale, A. do; Ludovico, P.. "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813 12 (2011): 2044-2049. http://dx.doi.org/10.1016/j.bbamcr.2011.09.010.
    10.1016/j.bbamcr.2011.09.010
  42. Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Fernando; Ludovico, Paula. "Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?". Biochemical Society Transactions 39 5 (2011): 1466-1470. http://dx.doi.org/10.1042/bst0391466.
    10.1042/bst0391466
  43. Mendes-Ferreira, Ana; Sampaio-Marques, Belém; Barbosa, Catarina; Rodrigues, Fernando; Costa, Vítor; Mendes-Faia, Arlete; Ludovico, Paula; Leão, Cecília. "Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae". Applied and Environmental Microbiology 76 24 (2010): 7918-7924. http://dx.doi.org/10.1128/aem.01535-10.
    10.1128/aem.01535-10
  44. Mesquita, A.; Weinberger, M.; Silva, A.; Sampaio-Marques, Belém; Almeida, B.; Leao, C.; Costa, V.; et al. "Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity". Proceedings of the National Academy of Sciences 107 34 (2010): 15123-15128. http://dx.doi.org/10.1073/pnas.1004432107.
    10.1073/pnas.1004432107
  45. Almeida, A.J.; Cunha, C.; Carmona, J.A.; Sampaio-Marques, Belém; Carvalho, A.; Malavazi, I.; Steensma, H.Y.; et al. "Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis". Fungal Genetics and Biology 46 12 (2009): 919-926. http://dx.doi.org/10.1016/j.fgb.2009.08.004.
    10.1016/j.fgb.2009.08.004
  46. Osório, N. S.; Sampaio-Marques, B.; Chan, C.-H.; Oliveira, P.; Pearce, D. A.; Sousa, N.; Rodrigues, F.. "Neurodevelopmental delay in theCln3ex7/8mouse model for Batten disease". Genes, Brain and Behavior 8 3 (2009): 337-345. http://dx.doi.org/10.1111/j.1601-183x.2009.00478.x.
    10.1111/j.1601-183x.2009.00478.x
  47. Almeida, B.; Silva, A.; Mesquita, A.; Sampaio-Marques, B.; Rodrigues, F.; Ludovico, P.. "Drug-induced apoptosis in yeast". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783 7 (2008): 1436-1448. http://dx.doi.org/10.1016/j.bbamcr.2008.01.005.
    10.1016/j.bbamcr.2008.01.005
  48. Almeida, Bruno; Buttner, Sabrina; Ohlmeier, Steffen; Silva, Alexandra; Mesquita, Ana; Sampaio-Marques, Belém; Oso´rio, Nuno S.; et al. "NO-mediated apoptosis in yeast". Journal of Cell Science 120 18 (2007): 3279-3288. http://dx.doi.org/10.1242/jcs.010926.
    10.1242/jcs.010926
  49. Gomes, Pedro; Sampaio-Marques, Belém; Ludovico, Paula; Rodrigues, Fernando; Leão, Cecília. "Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span". Mechanisms of Ageing and Development 128 5-6 (2007): 383-391. http://dx.doi.org/10.1016/j.mad.2007.04.003.
    10.1016/j.mad.2007.04.003
  50. Almeida, B.; Sampaio-Marques, B.; Carvalho, J.; Silva, M.T.; Leão, C.; Rodrigues, F.; Ludovico, P.. "An atypical active cell death process underlies the fungicidal activity of ciclopirox olamine against the yeast Saccharomyces cerevisiae". FEMS Yeast Research 7 3 (2007): 404-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147118520&partnerID=MN8TOARS.
    10.1111/j.1567-1364.2006.00188.x
Thesis / Dissertation
  1. Sampaio-Marques, B. "The emerging role of autophagy/mitophagy in a-synuclein-induced toxicity: studies on the yeast chronological aging model". PhD, Universidade do Minho - Escola de Medicina, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/23 Poster presentation: Sampaio-Marques B, Pereira HR, Paiva S and Ludovico P. Abrogation of endocytosis blocks the spread of alpha-synuclein in the yeast model of synucleinopathies. Microbiotec'21, November 2021, Virtual edition. Microbiotec'21
2021/11/23 Poster presentation: Ferreira B, Gomez M, Dourado S, Martins C, Sampaio-Marques B and Ludovico P. The effect of alternative sugars in the yeast Saccharomyces cerevisiae fitness. Microbiotec'21, November 2021, Virtual edition. MICROBIOTEC’21
2021/06/14 Poster presentation: . Lameira I, Martins M, Sampaio-Marques B, Ludovico P and Areias AC. Flow cytometry as a tool to characterize an engineered 3D in vitro model of Acute Myeloid Leukemia. XVII Congress of the Iberian Society of Cytometry, June 2021, Virtual edition XVII Congress of the Iberian Society of Cytometry
2021/06/14 Poster presentation: Barros M*, Cunha S *, Areias AC, Ludovico P and Sampaio-Marques B. Detection of Exosomes by conventional flow cytometry: protocol optimization. XVII Congress of the Iberian Society of Cytometry, June 2021, Virtual edition. XVII Congress of the Iberian Society of Cytometry
2021/06/09 Poster presentation: Areias AC, Castro I, Sampaio-Marques B, Sousa H, Fernandes A, Sanchez-Maldonado JM, Cunha C, Carvalho A, Sainz J and Ludovico P. Association of ATG10 functional genetic variants in Acute Myeloid Leukemia. EHA 2021, June 2021, Virtual edition. EHA2021 Virtual
2019/04/23 Alpha-synuclein induces DNA damage and autophagy degradation of ribonucleotide reductase 1 in yeast and human cells COST Transautophagy: Annual Meeting
(Sofia, Bulgaria)
2018/06/08 Caloric restriction rescues aged yeast cells from a-synuclein toxicity through regulation of proteolytic systems XXI Jornadas de Biologia de Leveduras "Professor Nicolau van Uden"
(Braga, Portugal)
2016/12/09 Caloric restriction alleviates a-synuclein toxicity-induced premature aging through modulation of Sir2 XIX Congresso Nacional de Bioquimica
(Guimarães, Portugal)
2016/11/05 The impact of a-synuclein on proteostasis and longevity: the crosstalk betwwen Tor1 and Sir2. Proteostasis and its Biological Implications
2015/09/30 Heterologous expression of alpha-synuclein in yeast aged cells promotes DNA replication stress. 11th International Meeting on Yeast Apoptosis - IMYA XI
(Porto, Portugal)
2014/07/12 The emerging role of autophagy and mitophagy in a-synuclein-induced toxicity: studies on the yeast chronological aging model XX Jornadas de Biologia de Leveduras Nicolau van Uden
(Lisboa, Portugal)
2012/06/15 Autophagy and aged yeast cells: response to proteotoxic stress under caloric restriction. XIX Jornadas de Biologia de Leveduras Nicolau van Uden
(Lisboa, Portugal)
2011/05/04 Proteotoxic stress and yeast chronological lifespan 8th IMYA – International Meeting on Yeast Apoptosis
(Kent, United Kingdom)
2009/11/29 Oxidative stress during chronological life span in Saccharomyces cerevisiae Microbiotec 09
(Vilamoura, Portugal)
2007 Evidence for NO-mediated apoptosis in yeast XIII International Conference on Yeast Genetics and Molecular Biology
(Melbourne, Australia)
2007 Óxido nítrico como mediador da apoptose em Saccharomyces cerevisiae XV Jornadas de Biologia de Leveduras Prof. Nicolau van UDEN
(Porto, Portugal)
2007 Survival/Death of Saccharomyces cerevisiae stationary phase cells: nutrient effects XV Jornadas de Biologia de Leveduras Prof. Nicolau van UDEN
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/05/01 - 2023/06/30 Studying the impact of autophagy's molecular regulation on aging
Supervisor
 Bioquímica (Degree)
Universidade do Minho, Portugal
2023/05/01 - 2023/06/30 Implications of the Autophagy Core Gene Variations in Acute Myeloid Leukemia
Co-supervisor
 Bioquímica (Degree)
Universidade do Minho, Portugal
2021/09/01 - 2022/12/30 Study on the effects of food supplements on yeast chronological aging
Supervisor
 Master in Health Sciences (Master)
Universidade do Minho Escola de Medicina, Portugal
2021/09/01 - 2022/12/30 Exossomas como Potenciais Biomarcadores da Doença de Fabry
Co-supervisor of Bruna Rafaela Coelho Ribeiro
Ciências de Engenharia Biomédica (Master)
Universidade do Minho, Portugal
2017 - 2022/03/30 The role of cell signalling during yeast chronological lifespan
Supervisor of Hélder Ricardo Cardoso Pereira
 Ciências da Saúde (PhD)
Universidade do Minho, Portugal
2020/10/01 - 2022/02/25 Amino acids homeostasis meets aging: studies in the yeast model
Supervisor
 Bioquímica Aplicada (Master)
Universidade do Minho, Portugal
2020/10/01 - 2022/02/15 Detection and quantification of cell-free circulating nucleic acids (cfCNAs) in blood samples of patients with acute myeloid leukemia (AML): Protocol optimization
Supervisor
 Bioquímica Aplicada (Master)
Universidade do Minho, Portugal
2020/10/01 - 2021/12/30 Isolation and characterization of extracellular vesicles from bone marrow of patients with cardiovascular diseases and blood cancer
Co-supervisor
 Ciências da Saúde (Master)
Universidade do Minho, Portugal
2019/10/21 - 2019/12/13 Exploiting Metabolic Reprogramming on Acute Myeloid Leukemia (AML) response to chemotherapy
Co-supervisor of Helena Maria Ferreira da Silva
 Medicina (Other)
Universidade do Minho, Portugal
2018/01/07 - 2019/02/28 Caloric restriction rescues aged yeast cells from a-synuclein toxicity through regulation of proteolytic systems
Supervisor of Hélder Pereira
 PhD program in Health Sciences (Other)
Universidade do Minho, Portugal
2018/10 - 2018/12 The effects of arginine supplementation on a-synuclein-mediated toxicity: studies on yeast aging mode
Co-supervisor of Maria de Fátima Moreira de Carvalho
 Medicina (Other)
Universidade do Minho, Portugal
2018/03 - 2018/05 Glutaminolysis-autophagy crosstalk in acute myeloid leukemia cells: combined effect of chemotherapy and glutaminolysis inhibition
Co-supervisor
 Master in Health Sciences (Other)
Universidade do Minho, Portugal
2017 - 2018 Anti-aging strategies in yeast: the impact of amino acids supplementation
Supervisor of Ana Rita Fernandes dos Santos
 Ciências da Saúde (Master)
Universidade do Minho, Portugal
2016/05/01 - 2016/07/31 Modelo de levedura da proteína associada à doença de Parkinson, Parkin: caracterização da sua função durante o envelhecimento cronológico.
Supervisor of Ana Maria Relvas da Silva Cunha
 Biologia (Degree)
Universidade do Minho, Portugal
2015/04 - 2015/05 The role of the yeast sucrose non-fermenting protein (Snf1) kinase in the regulation of autophagy in yeast aged cells under a-synuclein-mediated toxicity
Co-supervisor of , Tânia Sofia Martins Marques
 Inter-university doctoral programme in Ageing and Chronic disease (Other)
Universidade do Minho - Escola de Medicina, Portugal
2015/03 - 2015/04 The interplay between autophagy and DNA replication stress during aging: the role of the of the yeast sucrose non-fermenting protein (Snf1) kinase
Co-supervisor
 Inter-university doctoral program in Ageing and Chronic disease (Other)
Universidade do Minho - Escola de Medicina, Portugal
2014/05/01 - 2014/06/30 Caracterização da autofagia como resposta ao stress associado à replicação de DNA durante o envelhecimento: o papel da proteína cinase não-fermentadora de sacarose (SNF1) de levedura
Supervisor of Liliane Calçada Barroso
 Biologia (Degree)
Universidade do Minho, Portugal
2014/05/01 - 2014/06/30 A relação entre a via de TOR1 (Target of rapamycin) e Sir2 na regulação da autofagia em células envelhecidas em condições de restrição calórica
Supervisor of Andreia Daniela Cardoso Fernandes
 Biologia (Degree)
Universidade do Minho, Portugal
2013/10 - 2013/12 The role of alpha-synuclein toxicity in DNA replication stress: study on a yeast cellular model of aging
Co-supervisor of Igor Vasilevskiy
 Medicina (Other)
Universidade do Minho, Portugal
2012/07/01 - 2012/07/31 Construction of yeast models for assessment of autophagy in the study of Huntington’s disease
Co-supervisor of Jorge Diogo Cruz Ramos Silva
 Medicina (Other)
Universidade do Minho, Portugal
2011/05 - 2011/06 Construction of yeast models (Saccharomyces cerevisiae) for assessment of mitophagy and macroautophagy in the study of Parkinson’s disease
Co-supervisor of João Pacheco
 Medicina (Other)
Universidade do Minho, Portugal
2011/04 - 2011/05 The role of mitophagy on a-synuclein toxicity in aged yeast
Co-supervisor of Filipa Carvalho Marques
 Inter-university doctoral programme in Ageing and Chronic disease (Other)
Universidade do Minho - Escola de Medicina, Portugal
2010/10 - 2010/12 Heterologous expression of alpha-synuclein, wild-type and A53T mutant form, induces autophagy in yeast
Co-supervisor
 Medicina (Other)
Universidade do Minho, Portugal
2010/05 - 2010/06 Evaluation of the expression of a-synuclein protein in the yeast model of Parkinson disease
Supervisor of Daniela Fernandes
 Medicina (Other)
Universidade do Minho, Portugal
2010/05 - 2010/06 Evaluation of the expression of huntingtin protein in the yeast model for Huntington disease
Supervisor of Inês Pires
 Medicina (Other)
Universidade do Minho, Portugal
2009/06/01 - 2009/07/31 Evaluation of IRES-mediated HSP90 expression during yeast programmed cell death
Co-supervisor of Tiago Mota
 Medicina (Other)
Universidade do Minho, Portugal
2009/05 - 2009/06 alpha-Synuclein toxicity in yeast aged cells: the role of autophagy
Co-supervisor of Vitor Hugo Dias Martins
 PhD program in Health Sciences (Other)
Universidade do Minho - Escola de Medicina, Portugal
2008/05 - 2008/06 Evaluation of metacaspase digestome in the yeast model of Parkinson disease
Co-supervisor of Hugo Monteiro
 Medicina (Other)
Universidade do Minho, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/04/11 - 2023/04/28 Pos-graduation course: CELL FUNCTIONAL AND PHENOTYPICAL ANALYSIS: the usefulness of flow cytometry and related tools (5th ed) (2021/04/12 - 2021/04/30) (2023/04/11 - 2023/04/28)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/04/12 - 2021/04/30 Pos-graduation course: CELL FUNCTIONAL AND PHENOTYPICAL ANALYSIS: the usefulness of flow cytometry and related tools (4th ed) (2021/04/12 - 2021/04/30)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/02/11 - 2019/02/22 Pos-graduation course: CELL FUNCTIONAL AND PHENOTYPICAL ANALYSIS: the usefulness of flow cytometry and related tools (3rd Edition) (2019/02/11 - 2019/02/22)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/04/03 - 2017/04/21 Pos Graduation course: CELL FUNCTIONAL AND PHENOTYPICAL ANALYSIS: the usefulness of flow cytometry and related tools (2nd Edition) (2017/04/03 - 2017/04/21)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/03/29 - 2016/04/08 Pos-graduation course: CELL FUNCTIONAL AND PHENOTYPICAL ANALYSIS: the usefulness of flow cytometry and related tools (2016/03/29 - 2016/04/08)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/09/29 - 2015/10/03 The International Meeting on Yeast Apoptosis. In this conference coveredr areas like Cell death/Pathways, Organelles in cell death, Yeast models in cancer and other diseases. (2015/09/29 - 2015/10/03)
Congress (Member of the Organising Committee)
 Universidade do Minho, Portugal
2015/04/07 - 2015/04/10 Pos graduation course: AUTOPHAGY IN HEALTH AND DISEASE: CONCEPTUAL AND METHODOLOGICAL ADVANCES. (2015/04/07 - 2015/04/10)
Other (Co-organisor)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/11 The unique biology of RNA protein granules in brain pathologies
(Thesis) Main arguer
 Beatriz Barros dos Santos (Master)
Universidade do Minho Departamento de Biologia, Portugal
2023/10/19 Administration of MSCs Secretome as a Therapeutic Strategy for Neonatal Hypoxic Ischemic Encephalopathy
(Thesis) Main arguer
 Andreia Filipa Francisco Valente da Silva (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2023/02/22 Novel Psychoactive Substances and Parkinson’s Disease: Molecular and cellular mechanisms of a-synuclein aggregation in the presence of synthetic cannabinoids and cathinones
(Thesis) Main arguer
 Carla Filipa da Silva Ferreira (PhD)
Universidade do Porto, Portugal
2022/07/04 Regulation of pulmonary CD4 T cell responses to Mycobacterium tuberculosis infection
(Thesis) Arguer
 Catarina Machado Ferreira (PhD)
Universidade do Minho, Portugal
2022/02/01 New method for monitoring the progression of cell death
(Thesis) Main arguer
 António José Gonçalves Ribeiro (Master)
Universidade do Minho Escola de Ciências, Portugal
2021/12/13 Searching for mitochondrial targets of the ubiquitin ligase APC/CCdh1
(Thesis) Main arguer
 Maria Barbedo Ramalho Figueiredo Tavares (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2021/10/21 Study of the metabolic profile in Acute Myeloid Leukemia (AML) cell lines.
(Thesis) Main arguer
 Ricardo Rafael Figueiredo de Sousa (Master)
Universidade do Minho Centro de Química, Portugal
2018 Anti-aging strategies in yeast: the impact of amino acids supplementation
Supervisor
 Ana Rita Fernandes dos Santos (Master)
Universidade do Minho - Escola de Medicina, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/01/01 - 2021/12/31 Cancers (2072-6694) MDPI
2021/01/01 - 2021/12/31 Metabolites (2218-1989) MDPI
2021/01/01 - 2021/12/31 Antioxidants (2076-3921) MDPI
2021/01/01 - 2021/12/31 Cells (2073-4409) MDPI
2021/01/01 - 2021/12/31 Yeast (1097-0061) Wiley Online Library
2021/01/01 - 2021/12/31 Life (2075-1729) MDPI
2021/01/01 - 2021/12/31 Frontiers in Cell and Developmental Biology (2296-634X) Frontiers
2020/09/09 - 2020/09/27 Scientific Reports (2045-2322 ) Nature Publishing Group
2020/05/22 - 2020/06/07 Proteomics and System Biology (1615-9861) Wiley Online Library
2020/02/12 - 2020/03/12 Proteomics and Systems Biology (1615-9861) Wiley Online Library
2020/01 - 2020/01 Yeast (1097-0061) Wiley (Blackwell Publishing)
2019/05 - 2019/05 PROTEOMICS (1615-9861) Wiley (John Wiley & Sons)
2018/08 - 2018/08 Environmental Technology & Innovation (2352-1864) Elsevier
2017/10 - 2017/12 Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2017/09 - 2017/09 Annals of the New York Academy of Sciences (1749-6632) Wiley (Blackwell Publishing)
2016/10 - 2017/06 Journal of Neuroscience Research (1097-4547) Wiley (John Wiley & Sons)
2016/02 - 2016/05 Journal of Cellular and Molecular Medicine (1582-4934) Wiley (Blackwell Publishing)
2015/06 - 2015/06 Microbial Cell (2311-2638) Shared Science Publishers OG
2014/11 - 2014/12 DNA and Cell Biology (1557-7430) Mary Ann Liebert
2014/09/01 - 2014/09/15 Journal of Biochemistry (0021-924X) Heighten Science Publications Corporation
2013/05/13 - 2013/06/02 Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited

Committee member

Activity description
Role 		Institution / Organization
2020/03/31 - Current COVID19 Diagnosis - A team of volunteers to diagnosis COVID-19 was created at Life and Health Sciences Research Institute (ICVS).
Coordinator
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016 - Current Members of the “ICVS International Seminars”. These seminars give a unique opportunity interact and discuss with distinguished and internationally renowned researchers in many areas of life and health.
Member
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/01 - Current Academic Profile 1 Medicina (Licenciatura) Universidade do Minho, Portugal
2023/01 - Current Academic Profile 2 Medicina (Licenciatura) Universidade do Minho, Portugal
2022/05 - Current Fundamentals of Medicine 2 Medicina (Licenciatura) Universidade do Minho, Portugal
2021/11 - Current Fundamentals of Medicine 1 Medicina (Licenciatura) Universidade do Minho, Portugal
2021/09 - Current Introduction to Training in Medicine Medicina (Licenciatura) Universidade do Minho, Portugal
2023/09/12 - 2023/11/29 Introduction to Training in Medicine Medicina (Licenciatura) Universidade do Minho, Portugal
2014/09 - 2019/06 Cells and Molecules in the Degree of Medicine Medicina (Mestrado integrado) Universidade do Minho, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/05/01 - 2023/05/12 Evaluation of the proposal with the title: Utilizing Nanopore Sequencing to Determine Mitochondrial Terminators. Candidate: Laura Marvin
Evaluator
 Graduate Women in Science, United States Graduate Women in Science
2021/09/15 - 2021/10/15 Evaluation of the grant proposal: The adaptive role of Quiescent:Non-Quiescent cells ratio in Saccharomyces cerevisiae yeast populations with registration number 2021/41/N/NZ8/02953 submitted to National Science Center
Evaluator
 National Science Centre (NCN), Poland National Science Centre (NCN)
2021/03/01 - 2021/05/03 Evaluation of the proposal with the title: ATPGobble: tool to manipulate ATP/ADP ratio in vivo. Candidate: Alexandra Evelyn Ekvik.
Evaluator
 Graduate Women in Science, United States Graduate Women in Science
2021/03/01 - 2021/05/03 Evaluation of the proposal with the title: Revealing the Mechanisms of Candida albicans Antifungal Tolerance using High-ThroughputMicrocolony Tracking. Candidate: Federica Sartori.
Evaluator
 Graduate Women in Science, United States Graduate Women in Science
2020/09/01 - 2020/09/15 Evaluation of a project proposal from BBSRC
Evaluator
 Biotechnology and Biological Sciences Research Council, United Kingdom Biotechnology and Biological Sciences Research Council
2020/07/06 - 2020/07/22 Innovate Competition - iMed Conference 12.0 Lisbon. This conference included an Innovate Contest, which awards research grants, totaling 8,000, to the winners. I participate in the pre-selection phase of research projects through the evaluation of 3 projects.
Evaluator
2020/03/03 - 2020/06/03 Reviewer for the Graduate Women in Science (GWIS) National Fellowship Program. Evaluation of the research proposal: Elucidating How Mutants Remotely Control Xylanase A Enzyme Activity.
Evaluator
 Graduate Women in Science, United States Graduate Women in Science

Journal scientific committee

Journal title (ISSN) Publisher
2022/09 - Current Frontiers in Cell and Developmental Biology - Stem Cell Research (2296-634X ) Frontiers
Distinctions

Award

2021 Best Poster Communication Award MICROBIOTEC 2021
Sociedade Portuguesa de Microbiologia, Portugal

Portuguese Society of Biotechnology, Portugal
2017 1º INL-ICVS Hackathon
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2014 Prémio Curso Young Investigator
2013 Young Scientist Prize - SPM Tribute to Isabel Spencer-Martins
2007 "Young Investigator Award" for a Poster Presentation