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Ana Lúcia Marques Batista de Carvalho has a PhD in Biosciences (2017) by University of Coimbra and her Master in Biochemistry in 2010 by University of Coimbra with her Master Thesis being developed at Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli. Presently she is a Junior Researcher at Unidade de I&D Química-Física Molecular of the University of Coimbra within the CEEC 2017 call. She has published 39 articles in journals with peer review with a total of 526 citations and H-index of 14 (search done by author Batista de Carvalho, A.L.M.). Supervised or co-supervised several MSc and BSc students. She is presently co-supervisor of 3 PhD student. She participated in 4 projects and is presently a member of two funded R&D Project NeedfoRSpeed (2022.03336.PTDC) and BetterBone (2022.04286.PTDC). She is an Associated member of the Royal Society of Chemistry (RSC), belongs to the Clinical Infrared and Raman Spectroscopy for Medical Diagnosis (CLIRSPEC) as well as to the Portuguese Society of Biochemistry (SPB). She has expertise in applying vibrational spectroscopy (FTIR (either benchtop or Syncrothron radiation), Raman and with neutrons) to the study of biological samples such as human cells and tissues. She is currently conducting research on the identification, using vibrational spectroscopy, of early liver rejection biomarkers in liver biopsies demonstrating scientific independence with 2 papers published as senior author and 6 as corresponding author . She is also enrolled in the design of Pt/Pd-based anticancer agents.
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Identification

Personal identification

Full name
ANA LÚCIA MARQUES BATISTA DE CARVALHO

Citation names

  • Ana L. M. Batista de Carvalho
  • Batista de Carvalho, A.L.M.
  • A.L.M., Batista de Carvalho

Author identifiers

Ciência ID
4419-A4AF-3D7C
ORCID iD
0000-0003-1280-3321
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=_WaX7AEAAAAJ&view_op=list_works&sortby=pubdate
Researcher Id
A-2929-2014
Scopus Author Id
55355733500

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences
  • Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2023/03/30 - 2023/03/30
Concluded
 Workshop sobre Género e Liderança para a Excelência na Investigação (Outros)
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/07/19 - 2022/07/19
Concluded
 Curso de Boas Práticas na Orientação Doutoral (Outros)
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/03/15 - 2022/03/15
Concluded
 Gestão de Dados de Investigação (Outros)
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/02/22 - 2022/02/22
Concluded
 Supervisão Doutoral: Abordagens e Práticas (Outros)
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2022/02/07 - 2022/02/07
Concluded
 TIMB3 Workshop Imaging in Biosciences (Outros)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2021/11/18 - 2021/11/19
Concluded
 Joint FEBS/SPB/UMinho Symposium on Evidence Based Teaching in Your Biomolecular Classroom: Catalysing Student Engagement (Outros)
Universidade do Minho, Portugal
2021/03/23 - 2021/03/25
Concluded
 Advanced Infrared Microspectroscopy Analysis Training - QUASAR software (Outros)
Diamond Light Source Ltd, United Kingdom
2018/10/10 - 2018/10/12
Concluded
 Interdisciplinary Summer School on Clinical Biophotonics (Outros)
Raman4Clinics, Germany
2017/03/19 - 2017/03/21
Concluded
 X-Ray Absorption Spectroscopy Workshop (Outros)
Diamond Light Source, United Kingdom
2017
Concluded
 Doutoramento em Biociências especialização em Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Cisplatin-like Compounds as Potential Chemotherapeutics: from the Bench to the Cell." (THESIS/DISSERTATION)
 Aprovado com distinção e louvor por unanimidade
2016 - 2016
Concluded
 Interdisciplinary Summer School on Clinical Biophotonics (Outros)
Raman4Clinics, Germany
2015 - 2015
Concluded
 SALSA Summer University 2015 - Sensitivity & Selectivity (Outros)
School of Analytical Sciences Adlershof , Germany
2014 - 2014
Concluded
 Multivariate IR Microspectroscopy Analysis Training Course – Unscrambler X (Outros)
Diamond Light Source, United Kingdom
2014 - 2014
Concluded
 Hands-on course on Microscopy Analysis Imaging at the Center for Neuroscien (Outros)
Centro de Neurociências Coimbra, Portugal
2013 - 2013
Concluded
 Ciência em Animais de Laboratório - Categoria B (Outros)
Universidade do Porto, Portugal
2013 - 2013
Concluded
 Segurança e Saúde Ocupacional em Laboratórios (Outros)
Biocant Park - Formações Microbiologia, Portugal
2011 - 2011
Concluded
 Biostatistics (Outros)
Centro de Neurociências Coimbra, Portugal
2010
Concluded
 2º Ciclo em Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universita degli Studi di Roma La Sapienza Dipartimento di Scienze Biochimiche Alessandro Rossi Fanelli, Italy
"Cytotoxic Effect Induced by Combination of Polyamines Metabolites and Endocannabinoid, Anandamide, on Human Cancer Cell: A New Anticancer Strategy" (THESIS/DISSERTATION)
 17
2005 - 2008
Concluded
 1º Ciclo em Bioquímica (Licenciatura)
Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
"Caracterização Conformacional e Avaliação de Citotoxicidade de Complexos de Pt(II) e Pd(II) com Diaminas" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/05/16 - Current Contracted Researcher (Research) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2017/12/19 - 2018/12/18 Postdoc (Research) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2010/11 - 2017/08 Researcher (Research) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2009/10 - 2010/06 Research Trainee (Research) Università degli Studi di Roma La Sapienza, Italy
2008/02 - 2008/07 Research Trainee (Research) Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
Projects

Grant

Designation Funders
2015/07 - 2020/12 BioImpact - Biochemical Impact of Ptatinum and Palladium Anticancer Agents
PTDC/QEQ-MED/1890/2014
Researcher
Fundacao para a Ciencia e a Tecnologia
Concluded
2016 - 2017 ReNATURE - Valorisation of the NAtural Endogenous Resources of the Central Region of Portugal
Centro-01-0145-FEDER-000007
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2012 Actividade Anticancerígena de Novos Complexos de Pd(II) com Poliaminas - Um Estudo Multidisciplinar
PTDC/QUI/66701/2006
PhD Student Fellow
Unidade I&D Química-Físicia Molecular, Portugal
 Fundacao para a Ciencia e a Tecnologia
Concluded

Other

Designation Funders
2023/02/20 - Current BetterBone - Metabolite-activated 3D stem cell differentiation into bone
2022.04286.PTDC
Investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - Current NeedfoRSpeed - A compressive spectrometer for melanoma diagnosis
2022.03336.PTDC
Investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/18 - 2022/10/18 VibsONCancer - Molecular Cancer Diagnostics by Vibrational Spectroscopy
POCI-01-0145-FEDER-0016786
Centro-01-0145-FEDER-029956
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018/06/22 - 2021/06/21 Molecular Cancer Diagnostics by Vibrational Spectroscopy
PTDC/QUI-QAN/29956/2017
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Batista De Carvalho, A.L.M.; Fiuza, S.M.; Tomkinson, J.; Batista De Carvalho, L.A.E.; Marques, M.P.M.. Pt(II) complexes with linear diamines. I-Vibrational study of Pt-diaminopropane. 2013.
    10.3233/978-1-61499-184-7-147
Book chapter
  1. Batista de Carvalho, A.L.M.; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) Complexes with Linear Diamines. I - Vibrational Study of Pt-Diaminopropane". In Spectroscopy of Biological Molecules, 147-156. Lansdale: IOS Press, 2013.
    Published
Conference abstract
  1. Vojtek, Martin; Marques, Maria P. M.; Batista de Carvalho, Ana L. M.; Mota-Filipe, Helder; Ferreira, Isabel M. P. L. V. O.; Diniz, Carmen. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022.
    10.3390/ecmc2022-13469
Conference paper
  1. Martin Vojtek; Maria P. M. Marques; Ana L. M. Batista de Carvalho; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022.
    10.3390/ECMC2022-13469
  2. Marques, M.P.M.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Intracellular Water - A Secondary Target in Chemotherapy - Impact of Pt/Pd Anticancer Drugs in Breast Cancer Cells Probed by Neutron Techniques". Paper presented in 7th International Workshop on Electron-volt Neutron Spectroscopy, 2017.
  3. Oliveira, L.C.; Batista de Carvalho, A.L.M.; Marques, M.P.M.; Fonseca, A.P.. "Parameterising PDK1-Induced Perturbations on the Dose-Response Profile of Human Glioblastoma". 2016.
  4. Batista de Carvalho, A.L.M.; Tempera, G.; Viceconte, N.; Saccoccio, S.; Bidollari, E.; Nalli, M.; Morera, E.; et al. "Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: A new anticancer strategy". Paper presented in The 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
    Published • 10.1186/1753-6561-4-S2-P31
Conference poster
  1. Martins, Clara B.; Vojtek, M.; Diniz, C.; Batista de Carvalho, L. A. E.; Marques, MPM; Ana L. M. Batista de Carvalho. ""Metabolic effect of Pd(II) Trinuclear Chelate with spermidine on TNBC-Sensitive and -Resistant to cisplatin"". Paper presented in HIRES 2023 Synergies in High Resolution Spectroscopy, 2023.
  2. Vojtek, M. (5F15-7817-94DC); Marques, MPM; Ana L. M. Batista de Carvalho; Ferreira, I.M.P.L.V.O.; Mota-Filipe, H.; Diniz, C.. "Palladium-spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-independent Cell Death in Triple-negative Breast Cancer Cells". Paper presented in 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022), 2023.
  3. Carneiro, Tatiana J.; Vojtek, M. (5F15-7817-94DC); Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "O Perfil Metabólico de Tumor e Cérebro de Ratinhos Xenógrafos de Cancro da Mama Triplo-Negativo Revela Efeito Promissor do Complexo Pd2Espermina Relativamente a Cisplatina". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  4. Carneiro, Tatiana J.; Vojtek, M. (5F15-7817-94DC); Gonçalves-Monteiro, Salomé; Ana L. M. Batista de Carvalho; Marques, MPM; Diniz, C.; Gil, A.M.. "NMR metabolomics unveils a beneficial metabolic response of mice brain to Palladium(II)-Spermine, a possible alternative to cisplatin for cancer treatment". Paper presented in The 19th European Magnetic Resonance Congress (EUROMAR 2023), 2023.
  5. Martins, Clara B.; Vojtek, M. (5F15-7817-94DC); Diniz, C.; Batista de Carvalho, Luis Alberto Esteves; Marques, MPM; Ana L. M. Batista de Carvalho. "Metabolic Profiling of Breast Cancer Cell Lines by Vibrational Microspectroscopy". Paper presented in 47th FEBS Conference, 2023.
  6. Martins, Clara B.; Ana L. M. Batista de Carvalho; A. P. Mamede; Silva, J. D.; Santos, I.P.; Figueiredo, P. ; Sarter, M.; et al. "Unraveling the Healthy-to-Cancer Transition: Water Dynamics as a Key Biomarker". Paper presented in 9º Encontro Nacional de Utilizadores de Radiação de Sincrotrão, 2023.
  7. Martins, Clara B.; Ana L. M. Batista de Carvalho; A. P. Mamede; Silva, J.D.; Santos, I.P.; Figueiredo, P.; Sarter, M.; et al. "Unraveling the Healthy-to-Cancer Transition: Water Dynamics as a Key Biomarker". Paper presented in ILL Soft Matter Summer School, 2023.
  8. A.L.M., Batista de Carvalho. "Chemotherapeutic response to cisplatin and Pd2-Spm drugs in PC-3 cell line by FTIR microspectroscopy". Paper presented in VIII Encontro Nacional de Estudantes de Química (VIII ENEQUI), 2022.
  9. A.L.M., Batista de Carvalho. "Spectral Histopathology: A Brighter Future for Breast Cancer Diagnosis". Paper presented in 12th International Conference on Clinical Spectroscopy (SPEC 2022), 2022.
  10. A.L.M., Batista de Carvalho. "Who's who? Discrimination of Breast Cell Lines by Raman Microspectroscopy". Paper presented in 27th International Conference on Raman Spectroscopy (ICORS), 2022.
  11. A.L.M., Batista de Carvalho. "Who's who? Discrimination of Breast Cell Lines by FTIR Microspectroscopy". Paper presented in 19th European Conference on Spectroscopy of Biological Molecules, ECSBM 2022, 2022.
  12. Pires, C.L.; Praça, C.; Martins, P.A.T.; Ana L. M. Batista de Carvalho; Ferreira, L.; Marques, M.P.M.. "Re-use of Caco-2 Monolayers in Permeability Assays - Validation Regarding Cell Monolayer Integrity". Paper presented in 7th International Iberian Biophysics Congress, 2021.
  13. A. P. Mamede; Santos, I.P.; Figueiredo, P. ; Ana L. M. Batista de Carvalho; Marques, M.P.M.; Batista de Carvalho, L. A. E.. "Spectral Histopathology - A Rising Field for Breast Cancer Diagnosis". Paper presented in ICAVS11 Conference, 2021.
  14. Ana L. M. Batista de Carvalho. "Spectral Histopathology - A Rising Field for Breast Cancer Diagnosis". Paper presented in 11th International Conference on Advanced Vibrational Spectroscopy (ICAVS 11), 2021.
  15. Carneiro, T.; Araújo, A.R.; Diniz, C.; Batista de Carvalho, A.L.M.; Marques, M.P.M.; Gil, A.M.. "NMR Metabolomics to Assess Nephrotoxicity Induced by Cisplatin and Pd2(spermine) in a Mouse Model". Paper presented in Jornadas CICECO 2019 “Where Science Meets Society”, 2019.
  16. Batista de Carvalho, L.A.E.; Batista de Carvalho, A.L.M.; Parker, S.F.; Marques, M.P.M.. "Complete Vibrational Study of a Novel Pt(II)-based Anticancer Drug, by Combined FTIR, Raman and INS Techniques". Paper presented in SPEC Conference (SPEC 2018) – Shedding New Light on Disease, 2018.
  17. Mamede, A.P.; Matos, C.S.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Pt(II) and Pd(II) Polyamine Complexes in the Spotlight of Metastatic Prostate Cancer Treatment". Paper presented in 43rd FEBS Congress – Biochemistry Forever, 2018.
  18. Martins, A.S.; Batista de Carvalho, A.L.M.; Lamego, I.; Marques, M.P.M.; Gil, A.. "Cytotoxic Impact of Platinum and Palladium-based Drugs on MG-63 Cells". Paper presented in Jornadas CICECO 2018 “Living Science Together”, 2018.
  19. Dias, J.R.; Ana L. M. Batista de Carvalho; Barroca, M.J.; Moreira da Silva, A.. "Antioxidant and cytotoxic effects of Salicornia ramosissima extracts in cancer cells". Paper presented in 1st International Meeting on Innovation & Development in the Food Sector, 2018.
  20. Moreira da Silva, A.; Santos, L.; Simões, L.; Batista de Carvalho, A.L.M.; Barroca, M.J.. "Cytotoxic and Antioxidant Activities of White Portuguese Crowberry Extracts". Paper presented in 2nd Conference Food Bioactives & Health, 2018.
  21. Ana L. M. Batista de Carvalho; Doherty, J.; Gardner, P.; Frogley, M.; Cinque, G.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Probing Drug-DNA Interplay by THz Spectroscopy". Paper presented in 9th International Workshop on Infrared Microscopy and Spectroscopy with Accelerator Based Sources (WIRMS), 2017.
  22. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelly, C.; Batista de Carvalho, L.A.E; Marques, M.P.M.. "Impact of Quercetin on Chemotherapy Response in Metastatic Human Breast Cancer – A Vibrational Microspectroscopy Study". Paper presented in 42nd FEBS Congress – from Molecules to Cells and Back, 2017.
  23. Marques, M.P.M.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Anticancer Drug Impact on Intracellular Water". Paper presented in Meeting of the COST-BM1401 Working Group – Raman-based Applications for Clinical Diagnostics (Raman4Clinics), 2017.
  24. Ruano, C.; Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Otero, J.C.; Marques, M.P.M.. "Effect of Antioxidants on Breast Cancer Cells Probed by Raman Microspectroscopy". Paper presented in XXXVI Reunião Bienal da Real Sociedade Espanhola de Química, 2017.
  25. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Chemoprevention Strategies Against Melanoma - New Perspectives using Raman Microspectroscopy". Paper presented in RAMAN4CLINICS – SUMMER SCHOOL Clinical Biophotonics, 2016.
  26. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Potential Chemopreventive Compounds Against Melanoma - New perspective using Raman Spectroscopy". Paper presented in XXV Reunión Nacional de Espectroscopia (XXV RNE) - IX Congreso Ibérico de Espectroscopia (IX CIE), 2016.
  27. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelley, C.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Impact of Dietary Antioxidants on Chemotherapy Response Probed by Vibrational Microspectroscopy in Metastatic Human Breast Cancer". Paper presented in Faraday Discussions, 2016.
    10.1039/C6FD90024K
  28. Silva, A.; Batista de Carvalho, A.L.M.; Maia, C.; Ferreira, R.; Marques, M.P.M.; Batista de Carvalho, L.A.E.; Patício, M.; Roda, J.. "Prevalence of Subclinical Deficit of Vitamin K, Detected by Spectroscopy of Micro-Raman". Paper presented in RAMAN4CLINICS – SUMMER SCHOOL Clinical Biophotonics, 2016.
  29. Batista de Carvalho, A.L.M.; Pilling, M.; Gardner, P.; Doherty, J.; Cinque, G.; Wehbe, K.; Kelley, C.; Marques, M.P.M.; Batista de Carvalho, L.A.E.. "Chemotherapy Response of Quercetin Combined with a Cisplatin-like Agent Probed by Microvibrational Spectroscopy in Triple Negative Breast Cancer". Paper presented in IX CIE (IX Congresso Ibérico de Espectroscopia/XXV Reunión Española de Espectroscopía), 2016.
  30. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Garcia-Sakai, V.; Hatter, L.; Batista de Carvalho, L.A.E.. "Intracellular Water - an Overlooked Target of Drug Activity? Cisplatin´s Impact in Breast Cancer Cells Probed by Neutron Techniques". Paper presented in Workshop 50 Years of Neutron Backscattering Spectroscopy, 2016.
  31. Marques, M.P.M.; Cibin, G.; Gianolio, D.; Cinque, G.; Kelley, C.; Gardner, P.; Pilling, M.; et al. "Anticancer Drugs: from Molecule to Cell". Paper presented in Clinical Infrared and Raman Spectroscopy for Medical Diagnosis (CLIRSPEC) Network Conference, 2015.
  32. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Correlating Biological Activity and Chemical Fingerprint: Raman Microspectroscopy Studies in Human Cancer Cells". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, 2015.
  33. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Effect of Dietary Phytochemicals in Cancer: Raman Microspectroscopy Studies in Human Breast Cancer Cells". Paper presented in 6 th European Conference on Chemistry for Life Sciences (6 th ECCLS), 2015.
  34. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Cinque, G.; Kelley, C.; Gardner, P.; Pilling, M.; Doherty, J.; Marques, M.P.M.. "Raman Microspectroscopy Study of Cisplatin-like Complexes Behaviour on a Breast Cancer Cell Line". Paper presented in XVI European Conference on the Spectroscopy of Biological Molecules (ECSBM 16), 2015.
  35. Medeiros, P.S.C.; Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "Efeito de fitoquimicos da dieta na quimioprevenção do cancro: estudo de espectroscopia de Ramam em cancro de mama". Paper presented in I Encontro Científico NEQ/AAC, 2015.
  36. Costa, F.; Ana L. M. Batista de Carvalho; Marques, M.P.M.; Diniz, C.. "Anti-angiogenic Properties of a Paladium Derivative Compound - Pd2Spm". Paper presented in Reunião de Estudantes Investigadores da Universidade do Porto (IJUP),, 2014.
  37. Monteiro, J.; Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Impact of a Dietary Antioxidant in Cancer Cells: a Raman Microspectroscopy Study". Paper presented in VIII Congresso Ibérico de Espectroscopia/XXIV Reunión Española de Espectroscopía, 2014.
  38. Marques, M.P.M.; Lopes, R.P.; Gianolio, D.; Ana L. M. Batista de Carvalho; Cibin, G.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Parker, S.F.. "Pt-based Anticancer Drugs - DNA-Interaction and Acquired Resistance Probed by EXAFS and Simultaneous INS and Raman Scattering". Paper presented in SPEC 2014, 2014.
  39. Batista de Carvalho, L.A.E.; Parker, S.F.; Batista de Carvalho, A.L.M.; Amado, A.M.; Marques, M.P.M.. "Cyclodextrin-encapsulation of Platinum-based Anticancer Drugs". Paper presented in SPEC 2014, 2014.
  40. Batista de Carvalho, A.L.M.; Diniz, C.; Marques, M.P.M.. "Pd2-Spm and Docetaxcel as Potential Anti-angiogenic Agents: An In-vivo Study". Paper presented in XXIII EFMC-ISMC Symposium (XXIII International Symposium on Medicinal Chemistry), 2014.
  41. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Probing the Cellular Impact of Cisplatin on Human Breast Cancer Cells: a Raman Microspectroscopy Study". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  42. Matos, C.S.M.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Pt(II) and Pd(II) Polyamine Complexes as Promising Anticancer Approaches Towards Metastatic Prostate Cancer". Paper presented in Atualizações em Oncologia, Congress Cimago 2013, 2013.
  43. Batista de Carvalho, A.L.M.; Frias, C.R.; Otero, J.C.; Marques, M.P.M.. "In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy". Paper presented in 38º FEBS Congress (Federation of European Biochemical Societies) (FEBS2013), 2013.
  44. Batista de Carvalho, A.L.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "In Vitro Probing of Breast Cancer Cells by Raman Microspectroscopy". Paper presented in XV European Conference on the Spectroscopy of Biological Molecules (ECSBM11), 2013.
  45. Matos, C.S.M.; Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Multinuclear Pt(II) and Pd(II) Polyamine Complexes as Promising Anticancer Approaches Towards Metastatic Prostate Cancer". Paper presented in XI International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy, 2012.
  46. Batista de Carvalho, A.L.M.; Marques, M.P.M.. "Anti-Metastatic Activity of a Pd(II)-Spermine Complex Against Human Breast Cancer". Paper presented in XI International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy, 2012.
  47. Ana L. M. Batista de Carvalho; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) and Pd(II) Complexes with Linear Diamines - An INS Study". Paper presented in VII Congresso Ibérico de Espectroscopia/XXIII Reunión Española de Espectroscopía, 2012.
  48. Batista de Carvalho, A.L.M.; Fiuza, S.M.; Amado, A.M.; Marques, M.P.M.; Batista de Carvalho, L.A.E.. "Vibrational Study of Pt(dap)Cl2 and Pd(dap)Cl2". Paper presented in XIV European Conference on the Spectroscopy of Biological Molecules, 2011.
  49. Ana L. M. Batista de Carvalho; Agostinelli, E.; Viceconte, N.; Saccoccio, S.; Bidollari, E.; Nalli, M.; Morera, E.; Ortar, G.; Tempera, G.. "Overcoming Multi-drug Resistance - Polyamine Oxidative Products as Potential Cytotoxics". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  50. Batista de Carvalho, A.L.M.; Fiuza, S.M.; Amado, A.M.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Conformational Analysis of Pt(II) and Pd(II) Ethylenediamine Complexes". Paper presented in V Congresso Ibérico de Espectroscopia (V CIE), 2008.
Journal article
  1. Maria M. Félix; Mariana V. Tavares; Inês P. Santos; Ana L. M. Batista de Carvalho; Luís A. E. Batista de Carvalho; Maria Paula M. Marques. "Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy". Molecules 29 5 (2024): https://doi.org/10.3390/molecules29050922.
    Published • 10.3390/molecules29050922
  2. Carneiro, Tatiana J.; Ana L. M. Batista de Carvalho; Vojtek, Martin; Laginha, Raquel C.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry (2024):
    Published
  3. Bispo, Daniela S. C.; Correia, Marlene; Carneiro, Tatiana J.; Martins, Ana S.; Reis, Aliana A. N.; Batista de Carvalho, A.L.M.; Marques, Maria P. M.; Gil, Ana M.. "Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells". International Journal of Molecular Sciences 24 24 (2023): 17556. http://dx.doi.org/10.3390/ijms242417556.
    10.3390/ijms242417556
  4. Carneiro, Tatiana J.; A.L.M., Batista de Carvalho; Vojtek, Martin; Carmo, Inês F.; Marques, MPM; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0.
    10.1186/s12935-023-03124-0
  5. Marques, M. P. M.; A.L.M., Batista de Carvalho; Martins, C. B.; Silva, J. D.; Sarter, M.; García Sakai, V.; Stewart, J. R.; de Carvalho, L. A. E. Batista. "Cellular dynamics as a marker of normal-to-cancer transition in human cells". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-47649-w.
    10.1038/s41598-023-47649-w
  6. Pinto, Sara M. A.; Ferreira, Ana R. R.; Teixeira, Daniela S. S.; Nunes, Sandra C. C.; Batista de Carvalho, A.L.M.; Almeida, Joseany M. S.; Garda, Zoltan; et al. "Fluorinated Mn(III)/(II)-Porphyrin with Redox-Responsive 1H and 19F Relaxation Properties". Chemistry - A European Journal 29 53 (2023): http://dx.doi.org/10.1002/chem.202301442.
    10.1002/chem.202301442
  7. Martin Vojtek; Clara B. Martins; Raquel Ramos; Sara Gomes Duarte; Isabel M. P. L. V. O. Ferreira; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Carmen Diniz. "Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041205.
    10.3390/pharmaceutics15041205
  8. Jéssica D. Silva; Joana Marques; Inês P. Santos; Ana L. M. Batista de Carvalho; Clara B. Martins; Raquel C. Laginha; Luís A. E. Batista de Carvalho; Maria Paula M. Marques. "A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line". Molecules (2023): https://doi.org/10.3390/molecules28041698.
    10.3390/molecules28041698
  9. Raquel C. Laginha; Clara B. Martins; Ana L. C. Brandão; Joana Marques; M. Paula M. Marques; Luís A. E. Batista de Carvalho; Inês P. Santos; Ana L. M. Batista de Carvalho. "Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24031888.
    10.3390/ijms24031888
  10. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773.
    10.3390/ijms232213773
  11. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; João R. Neves; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics 14 2 (2022): 259-259. https://doi.org/10.3390/pharmaceutics14020259.
    10.3390/pharmaceutics14020259
  12. Martin Vojtek; Salomé Gonçalves-Monteiro; Patrícia Šeminská; Katarína Valová; Loreto Bellón; Patrícia Dias-Pereira; Franklim Marques; et al. "Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10020210.
    10.3390/biomedicines10020210
  13. Inês P. Santos; Clara B. Martins; Luís A. E. Batista de Carvalho; Maria P. M. Marques; Ana L. M. Batista de Carvalho. "Who's Who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR Microspectroscopy". Cancers (2022): https://doi.org/10.3390/cancers14020452.
    10.3390/cancers14020452
  14. Adriana P. Mamede; Inês P. Santos; Ana L. M. Batista de Carvalho; Paulo Figueiredo; Maria C. Silva; Maria P. M. Marques; Luís A. E. Batista de Carvalho. "Breast cancer or surrounding normal tissue? A successful discrimination by FTIR or Raman microspectroscopy". The Analyst (2022): https://doi.org/10.1039/D2AN00622G.
    10.1039/D2AN00622G
  15. M. P. M. Marques; I. P. Santos; A. L. M. Batista de Carvalho; A. P. Mamede; C. B. Martins; P. Figueiredo; M. Sarter; V. García Sakai; L. A. E. Batista de Carvalho. "Water dynamics in human cancer and non-cancer tissues". Physical Chemistry Chemical Physics (2022): https://doi.org/10.1039/D2CP00621A.
    10.1039/D2CP00621A
  16. Mamede, Adriana P.; Santos, Inês P.; Batista de Carvalho, Ana L. M.; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, Maria P. M.; Batista de Carvalho, Luís A. E.. "A New Look into Cancer - A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance". Cancers 13 21 (2021): 5336. http://dx.doi.org/10.3390/cancers13215336.
    10.3390/cancers13215336
  17. Mamede, Adriana P.; Santos, Inês P.; Ana L. M. Batista de Carvalho; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, Maria P. M.; Batista de Carvalho, Luís A. E.. "A New Look into Cancer - A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance". Cancers 13 21 (2021): 5336. http://dx.doi.org/10.3390/cancers13215336.
    Published • 10.3390/cancers13215336
  18. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775-10775. https://doi.org/10.3390/ijms221910775.
    10.3390/ijms221910775
  19. Cristiana L. Pires; Catarina Praça; Patrícia A. T. Martins; Ana L. M. Batista de Carvalho; Lino Ferreira; Maria Paula M. Marques; Maria João Moreno. "Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13101563.
    10.3390/pharmaceutics13101563
  20. Ana S. Martins; Ana L. M. Batista de Carvalho; Maria P. M. Marques; Ana M. Gil. "Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs". Molecules (2021): https://doi.org/10.3390/molecules26164805.
    10.3390/molecules26164805
  21. Batista de Carvalho, Luis Alberto Esteves; Mamede, Adriana Pereira; Batista de Carvalho, Ana Lucia Marques; Marques, Joana; Cinque, Gianfelice; Rudic, Svemir; Marques, Maria Paula Matos. "Metallodrug-protein interaction probed by synchrotron terahertz and neutron scattering spectroscopy". Biophysical Journal 120 15 (2021): 3070-3078. http://dx.doi.org/10.1016/j.bpj.2021.06.012.
    10.1016/j.bpj.2021.06.012
  22. Martin Vojtek; Salomé Gonçalves-Monteiro; Edgar Pinto; Sára Kalivodová; Agostinho Almeida; Maria P. M. Marques; Ana L. M. Batista de Carvalho; et al. "Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice". Pharmaceuticals 14 2 (2021): 173-173. https://doi.org/10.3390/ph14020173.
    10.3390/ph14020173
  23. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Ana M. Gil. "Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent". Metabolites 11 2 (2021): 114-114. https://doi.org/10.3390/metabo11020114.
    10.3390/metabo11020114
  24. M. P. M. Marques; A. L. M. Batista de Carvalho; A. P. Mamede; A. Dopplapudi; V. García Sakai; L. A. E. Batista de Carvalho. "Role of intracellular water in the normal-to-cancer transition in human cells—insights from quasi-elastic neutron scattering". Structural Dynamics (2020): https://doi.org/10.1063/4.0000021.
    10.1063/4.0000021
  25. Martins, Ana S.; Batista de Carvalho, Ana L.M.; Lamego, Inês; Marques, M.¿ Paula. M.; Gil, Ana M.. "Cytotoxicity of Platinum and Palladium Chelates against Osteosarcoma". ChemistrySelect 5 20 (2020): 5993-6000. http://dx.doi.org/10.1002/slct.202001361.
    10.1002/slct.202001361
  26. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Svemir Rudic; Madhusudan Tyagi; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. "A New Look into the Mode of Action of Metal-Based Anticancer Drugs". Molecules 25 2 (2020): 246-246. https://doi.org/10.3390/molecules25020246.
    10.3390/molecules25020246
  27. Marques, M. P. M.; Batista de Carvalho, A.L.M.; Mamede, A. P.; Rudic, S.; Dopplapudi, A.; García Sakai, V.; Batista de Carvalho, L. A. E.. "Intracellular water as a mediator of anticancer drug action". International Reviews in Physical Chemistry 39 1 (2020): 67-81. http://dx.doi.org/10.1080/0144235x.2020.1700083.
    10.1080/0144235x.2020.1700083
  28. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; C Diniz; Ana Batista de Carvalho; MPM Marques; Ana M. Gil. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites (2019): https://www.mdpi.com/2218-1989/9/11/279.
    10.3390/metabo9110279
  29. Maria Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Inês P. Santos; Victoria García Sakai; Asha Dopplapudi; Gianfelice Cinque; et al. "Chemotherapeutic Targets in Osteosarcoma: Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering". The Journal of Physical Chemistry B (2019): https://doi.org/10.1021/acs.jpcb.9b05596.
    10.1021/acs.jpcb.9b05596
  30. Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; James Doherty; Mark Frogley; Gianfelice Cinque; et al. "Anticancer drug impact on DNA - a study by neutron spectroscopy coupled with synchrotron-based FTIR and EXAFS". Physical Chemistry Chemical Physics (2019): https://doi.org/10.1039/C8CP05881D.
    10.1039/C8CP05881D
  31. Lucas D. Dias; Ana Batista de Carvalho; Sara Pinto; Gilberto; Mário J. F. Calvete; Liane M. Rossi; M. P. M. Marques; Mariette M. Pereira. "Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63)". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/52.
    10.3390/molecules24010052
  32. Batista de Carvalho, A.L.M.; Parker, S.F.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Novel platinum-based anticancer drug: a complete vibrational study". Acta Crystallographica Section C: Structural Chemistry 74 5 (2018): 628-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046549535&partnerID=MN8TOARS.
    10.1107/S2053229618005843
  33. Batista de Carvalho, A.L.M.; Caselli, F.; Rodrigues, V.; Paiva-Martins, F.; Marques, M.P.M.. "Antiproliferative Activity of Olive Oil Phenolics against Human Melan oma Cells". Letters in Drug Design & Discovery 14 9 (2017): 1053-1059.
    Published • 10.2174/1570180814666170110145658
  34. Marques, M.P.M.; Batista De Carvalho, A.L.M.; Sakai, V.G.; Hatter, L.; Batista De Carvalho, L.A.E.; Garcia-Sakai, V.. "Intracellular water-an overlooked drug target? Cisplatin impact in cancer cells probed by neutrons". Physical Chemistry Chemical Physics 19 4 (2017): 2702-2713. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021304395&partnerID=MN8TOARS.
    Published • 10.1039/c6cp05198g
  35. De Carvalho, A.L.M.B.; Medeiros, P.S.C.; Costa, F.M.; Ribeiro, V.P.; Sousa, J.B.; Diniz, C.; Marques, M.P.M.. "Anti-invasive and anti-proliferative synergism between docetaxel and a polynuclear Pd-spermine agent". PLoS ONE 11 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996537166&partnerID=MN8TOARS.
    10.1371/journal.pone.0167218
  36. A. L. M. Batista de Carvalho; M. Pilling; P. Gardner; J. Doherty; G. Cinque; K. Wehbe; C. Kelley; et al. "Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy". Faraday Discussions 187 - (2016): 273-298. https://doi.org/10.1039/C5FD00148J.
    Published • 10.1039/C5FD00148J
  37. Medeiros, P.S.C.; Batista De Carvalho, A.L.M.; Ruano, C.; Otero, J.C.; Marques, M.P.M.; Frias, C.R.. "Raman microspectroscopy for probing the impact of a dietary antioxidant on human breast cancer cells". Food and Function 7 6 (2016): 2800-2810. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975454450&partnerID=MN8TOARS.
    Published • 10.1039/c6fo00209a
  38. Batista de Carvalho, A.L.M.; Marques, M.P.M.; Frias, C.R.; Otero, J.C.. "In Vitro Probing of Human Refractory Prostate Cancer Cells by MicroRaman Spectroscopy". FEBS Journal- Main Symposia And Workshops 280 -- (2013): 3-617.
    Published • 10.1111/febs.12340
  39. Ana L. M. Batista de Carvalho; Fiuza, S.M.; Tomkinson, J.; Batista de Carvalho, L.A.E.; Marques, M.P.M.. "Pt(II) Complexes with Linear Diamines - Part I: Vibrational Study of Pt-Diaminopropane Dichloride". Spectroscopy: An International Journal 27 5-6 (2012): 403-413.
    Published • 10.1155/2012/206297
  40. Matos, C.S.; Ana L. M. Batista de Carvalho; Lopes, R.P.; Marques, M.P.M.. "New strategies against prostate cancer - Pt(II)-based chemotherapy". Current Medicinal Chemistry 19 27 (2012): 4678-4687. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875266301&partnerID=MN8TOARS.
Report
  1. A.L.M., Batista de Carvalho. 2022. Synchrotron Terahertz and Neutron Scattering Spectroscopies to Pave the Way to Understand Chemoresistance. https://www.diamond.ac.uk/docroot/flippingbooks/DiamondAnnualReview2022/index.html.
  2. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Martins, C.; Sarter, M.; Stewart, R; Garcia-Sakai, V.; Batista De Carvalho, L.A.E.. 2022. Cellular Dynamics as a Marker of Normal-to-Cancer Transformation. https://doi.org/10.5286/ISIS.E.RB2210188.
  3. Marques, M.P.M.; Ana L. M. Batista de Carvalho; Santos, I.; Mamede, Adriana; Garcia-Sakai, V.; Batista De Carvalho, L.A.E.. 2021. Probing Water Dynamics in Healthy and Cancer Human Tissues by QENS. https://doi.org/10.5286/ISIS.E.RB2010015.
  4. Marques, MPM; Ana L. M. Batista de Carvalho; A. P. Mamede; Dopplapudi, A.; García Sakai, V.; Batista De Carvalho, L.A.E.. 2021. Understanding Normal-to-Cancer Transition in Human Cells with the Use of Neutrons. https://doi.org/10.5286/ISIS.E.RB1910015.
  5. Marques, MPM; Ana L. M. Batista de Carvalho; Marques, J.; Rudic, S.; Batista De Carvalho, L.A.E.. 2020. Probing Chemoresistance to Pt- and Pd-Drugs by INS Spectroscopy. https://doi.org/10.5286/ISIS.E.RB2010013.
  6. Marques, MPM; Ana L. M. Batista de Carvalho; A. P. Mamede; García Sakai, V.; Dopplapudi, A.; Batista De Carvalho, L.A.E.. 2019. Understanding Normal-to-Cancer Transformation in Human Cells with the Use of Neutrons. https://doi.org/10.5286/ISIS.E.RB1910015.
  7. Marques, MPM; Ana L. M. Batista de Carvalho; Rudic, S.; Batista De Carvalho, L.A.E.. 2019. Probing Drug Pharmacodynamics by INS: The Effect of Cisplatin-like Anticancer Drugs on DNA. https://doi.org/10.5286/ISIS.E.RB1820103.
  8. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Dopplapudi, A.; Batista De Carvalho, L.A.E.. 2018. Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. https://doi.org/10.5286/ISIS.E.RB1810012.
  9. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Batista De Carvalho, L.A.E.. 2017. Probing Drug Pharmacodynamics by QENS - The Effect of Cisplatin-Like Anticancer Drugs on DNA Dynamical Profile. https://doi.org/10.5286/ISIS.E.RB1710167.
  10. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Batista De Carvalho, L.A.E.. 2017. Intracellular Water as a Secondary Drug Target in Chemotherapy: The Impact of a New Pd-Based Anticancer Agents on Human Breast Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1620050.
  11. Marques, MPM; Ana L. M. Batista de Carvalho; García Sakai, V.; Hatter, L.; Batista De Carvalho, L.A.E.. 2015. Drug Effects on Intracellular Water Dynamics: Cisplatin in Human Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1510054.
  12. Batista De Carvalho, L.A.E.; Ana L. M. Batista de Carvalho; García Sakai, V.; Hatter, L.; Vaz, P.D.; Marques, MPM. 2015. Drug Effects on Intracellular Water: Cisplatin in Human Cancer Cells. https://doi.org/10.5286/ISIS.E.RB1510053.
Thesis / Dissertation
  1. Carvalho, Ana Lúcia Marques Batista de. "Cisplatin-like Compounds as Potential Chemotherapeutics: from the Bench to the Cell". 2017. http://hdl.handle.net/10316/31864.

Other

Other output
  1. Intracellular water could help us distinguish between healthy and malignant cells. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2021 (highlight). 2021. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://www.isis.stfc.ac.uk/Pages/SH20_IntracellularWater.aspx.
  2. Metallodrug-protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy. Diamond Light Source Annual Report (2021) (highlight). 2021. A.L.M., Batista de Carvalho.
  3. Probing Chemoresistance to Pt- and Pd-Drugs via THz Spectroscopy. Diamond Light Source Annual Report 2019. 2019. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Adriana P. Mamede; Gianfelice Cinque; Luís A. E. Batista de Carvalho.
  4. Probing Drug Pharmacodynamics by INS: The Effect of Cisplatin-like Anticancer Drugs on DNA. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2019. 2019. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Svemir Rudic; Adriana P. Mamede; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1820103.
  5. Anticancer Drug Impact on DNA - A Study by Neutron Spectrocopy, Synchrotron-based FTIR and EXAFS. 2018. Ana L.M. Batista de Carvalho; Adriana P. Mamede; Asha Dopplapudi; Victoria Garcia Sakai; James Doherty; Mark Frogley; Gianfelice Cinque; et al. https://doi.org/10.1101/398826.
    10.1101/398826
  6. Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. Diamond Light Source Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Gianfelice Cinque; Luís A. E. Batista de Carvalho.
  7. An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs. Diamond Light Source Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Diego Gianolio; Luís A. E. Batista de Carvalho.
  8. Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2018. 2018. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Asha Dopplapudi; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1810012.
  9. Probing Drug Pharmacodynamics by QENS - The Effect of Cisplatin-Like Anticancer Drugs on DNA Dynamical Profile. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2017. 2017. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1710167.
  10. Intracellular Water as a Secondary Drug Target in Chemotherapy: The Impact of a New Pd-Based Anticancer Agents on Human Breast Cancer Cells. The Rutherford Appleton Laboratory, ISIS Facility Annual Report 2017. 2017. M. Paula M. Marques; Ana L. M. Batista de Carvalho; Victoria Garcia Sakai; Luís A. E. Batista de Carvalho. https://doi.org/10.5286/ISIS.E.RB1620050.
  11. Drug Effects on Intracellular Water: Cisplatin in Human Cancer Cells RB1510053. 2015. Batista de Carvalho, L.A.E.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Hatter, L.; Vaz, P.D.; Marques, M.P.M..
  12. Drug Effects on Intracellular Water Dynamics: Cisplatin in Human Breast Cancer Cells RB1400034. 2014. Marques, M.P.M.; Hatter, L.; Parker, S.F.; Batista de Carvalho, A.L.M.; Garcia-Sakai, V.; Batista de Carvalho, L.A.E..
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/01 New Strategies to Fight Cancer - The Role of Neutrons The Simulation Meets Molecular Spectroscopy (SiMol) Meeting
2023/11 Liver Graft rejection diagnosis by vibrational spectroscopy Reunião do Serviço de Anatomia Patológica do CHUC
(Coimbra, Portugal)
2023/10/26 Development of Palladium-spermine complex (Pd2Spm) for triple-negative breast cancer cells - in vitro and in vivo X Congresso Iberoamericano de Ciências Farmacêuticas
2023/10/11 Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatment European Large-Scale Facilities and the Research Infrastructures: Opportunities and How to Apply
(Portugal)
2023/09/01 Thriving Advantages of Drug Combination in Osteosarcoma Treatment - A Vibrational Microspectroscopy Study 12th International Conference on Advanced Vibrational Spectroscopy (ICAVS12)
(Poland)
2023/08/27 Advantages of FTIR Microspectroscopy with Synchrotron Radiation - an Inside View into Osteosarcoma Treatment 9º Encontro Nacional de Utilizadores de Radiação de Sincrotrão
(Portugal)
2023/07/08 NMR Metabolomics Unveils a Beneficial Metabolic Response of Mice Brain to Pd2Spermine, a Possible Alternative to Cisplatin in Cancer Treatment 19th European Magnetic Resonance Congress (EuroMar2023)
(United Kingdom)
2023/04/20 Shining the Beam on Human Cells and Tissues Molecular Spectroscopy Group Seminar Series
Royal Society of Chemistry
2023/04/04 Vibrational Microspectroscopy for the Discrimination of Breast Cancer Cell Lines XV Encontro Nacional de Química-Física
Sociedade Portuguesa de Química (Portugal)
2023 Pt and Pd-Complexes Against Breast Cancer International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship (4th edition)
(Portugal)
2022 Shining the Beam on Water in Human Cells and Tissues 3rd ESS ILL User Meeting
2022 The Biochemical Profile of Breast Cancer - Diagnosing with Raman Spectroscopy 27th International Conference on Raman Spectroscopy (ICORS)
2022 Role of Water Dynamics in Normal-to-Cancer Transition - Insights from Neutron Scattering Techniques 12th International Conference on Clinical Spectroscopy (SPEC 2022)
2022 Fluorinated Platforms for MRI Imaging 14º Encontro Nacional de Química Orgânica & 7º Encontro Nacional de Química Medicinal
2021 Intracellular Water Dynamics as a Mediator of Chemotherapy-induced Cell Death QENS-WINS 2021 Conference
2021 Normal-to-Cancer Transition - Insights from Quasi-elastic Neutron Scattering ICAVS11 Conference
2021 Anticancer Activity of Palladium-spermine Complex Against Triple-negative Breast Cancer 8th European Congress of Pharmacology (EPHAR 2021)
2020/01/08 Compostos Anticancerígenos - Novos medicamentos para o tratamento do cancro Programa Cientificamente Provável
Escola Secundária D. Duarte (Coimbra, Portugal)
2019 Shining the Beam on Cells - Intracellular Water as a Mediator of Anticancer Drug Action UK Neutron and Muon Science and User Meeting (NMSUM) 2019
2019 Probing Drug Pharmacodynamics by Optical and Neutron-based Vibrational Spectroscopy: Interaction of Cisplatin-like Anticancer Agents with DNA 10th International Conference on Advanced Vibrational Spectroscopy (ICAVS10)
2019 Shining the Beam on Biosystems: From Cancer Cells to Bones ILL – Synergies with Portugal Workshop,
2019 Synchrotron-based FTIR and Quasi-elastic Neutron Scattering in the Search for New Chemotherapeutic Targets Against Osteosarcoma XVIII European Conference on the Spectroscopy of Biological Molecules (ECSBM 18)
2019 Nuclear Magnetic Resonance Metabolomics to Evaluate the Metabolic Impact of Cisplatin and a Potential New Anti-cancer Drug - Palladium(II)-spermine - in a Mouse Model III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship
2018/10/12 Early Investigator Session - Ana Batista de Carvalho Raman4Clinics Summer School
(Coimbra, Portugal)
2018 Anticancer Metal-Polyamine Complexes Against Breast Cancer 11º Encontro de Investigação Jovem da Universidade do Porto (IJUP18)
2018 Anticancer Metal Complexes with Polyamines Against Breast Cancer: Cellular Uptake and Selective Cytotoxicity XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia
2018 Water - a Potential New Target for Chemotherapeutic Intervention? UK Neutron and Muon Science and User Meeting (NMSUM) 2018
2018 Searching for New Drug Targets - The Impact of Anticancer Drugs on Intracellular Water Probed by Neutron Spectroscopy SPEC Conference (SPEC 2018) – Shedding New Light on Disease
2018 Shining the Beam on Cells - In Search of Improved Anticancer Drugs 7th Annual Niels Bohr International Academy Workshop-School on ESS Science in Copenhagen (NBIA7): Deciphering the Hidden Dynamics of Soft Matter
2018 Metalloprophyrin as a Catalyst for the Synthesis of Diatereomeric (-)-isopulegol Epoxide: Antiproliferative Activity Against Human Osteosarcoma 7th EuCheMS Conference on Nitrogen Ligands
2017 Probing Breast Cancer Cells with Neutrons: The Impact of Anticancer Drugs on Intracellular Water
(United Kingdom)
2016 Synergetic Effect Induced by Docetaxel and Pd-spermine Complex in Human Triple Negative Breast Cancer Farmadrid
(Madrid, Spain)
2016 Vibracional Spectroscopy - Applications in Forensic and Medicinal Chemistry ANALÍTICA – 2016, 8º Encontro da Divisão de Química Analítica
(Lisboa, Portugal)
2016 Novel Chemotherapeutic Strategies Probed by Raman Spectroscopy Meeting of the COST-BM1401 Working Group – Raman-based Applications for Clinical Diagnostics (Raman4Clinics)
(Jena, Germany)
2016 Chemotherapeutic Response to Cisplatin-like Drugs in Human Breast Cancer Cells Probed by Vibrational Microspectroscopy Faraday Discussion “Advanced Vibrational Spectroscopy for Biomedical Applications
(Cambridge, United Kingdom)
2015 MicroRaman Spectroscopic Signature of Drug Action: Pd-Based Anticancer Agents Against Human Breast Cancer 8th International Conference on Advance Vibrational Spectroscopy (ICAVS 8)
(Viena, Austria)
2015 Spectral Signature of Drug Action - from the Bench to the Cell XVI European Conference on the Spectroscopy of Biological Molecules (ECSBM 16)
(Bochum, Germany)
2015 Efeito de Compostos Fenólicos Presentes na Dieta: Caso de Estudo por Espectroscopia de Raman em Células de Cancro de Mama Cientific Meeting of Chemistry Students Association of the University of Coimbra (NEQ/AAC)
(Coimbra, Portugal)
2012 Platinum and Palladium-based Anticancer Strategies - A Molecular View VII CIE (VII Congresso Ibérico de Espectroscopia/XXIII Reunión Española de Espectroscopía)
(Cordoba, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/01 - Current From Bench to Cell: A Roadmap to Fight Lung Cancer Based on Ni-Agents
Supervisor
 Biosciences (PhD) (PhD)
Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2022/09 - Current Liver Graft Rejection Diagnosis by Vibrational Spectroscopy
Supervisor
 Biosciences (PhD)
Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2020/12 - Current New Drugs to Fight Breast Cancer: a Close Look into Cellular Response
Co-supervisor
 Biosciences (PhD)
Universidade de Coimbra Departamento de Ciencias da Vida, Portugal
2022/09 - 2023/09 Estudo de complexos análogos de Pt(II) e Pd(II) em linha celular de osteossarcoma por microespectroscopia vibracional
Supervisor
 Chemistry (Master)
Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07 Estudo do impacto da cisplatina em linha celular saudável de próstata PNT-2 por microespectroscopia de FTIR
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07 Estudo do impacto da cisplatina em linha celular saudável de próstata PNT-2 por microespectroscopia de Raman
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07 Novos métodos de diagnóstico percoce de rejeição hepática - microespectroscopia de Raman
Supervisor
 Medicinal Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2022/02 - 2022/07 Novos métodos de diagnóstico precoce de rejeição hepática - microespectroscopia de FTIR
Co-supervisor
 Medicinal Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2022 - 2022 Desenvolvimento de Novos Agentes Anticancerígenos com Pd(II) Contra o Cancro do Cólon - Estudo por Microespetroscopia Vibracional
Supervisor
 Medicinal Chemistry (Degree)
Universidade de Coimbra, Portugal
2020/09 - 2021/12 New Pt and Pd-based Anticancer Agents Toward Colon Cancer
Co-supervisor
 Biochemistry (Master)
Universidade de Coimbra, Portugal
2021/02 - 2021/07 Resposta Quimioterapêutica de Compostos de Pd(II) em Células Humanas de Cancro da Próstata por Microespetroscopia de Raman
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2021/02 - 2021/07 Resposta Quimioterapêutica de Compostos de Pd(II) em Células Humanas de Cancro da Próstata por Microespetroscopia de FTIR
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2021/02 - 2021/07 Pt(II) and Pd(II) Polyamine Complexes as Novel Anticancer Agents
Co-supervisor
 Medicinal Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2020/02 - 2020/07 Identificação de biomarcadores espectrais em linhas celulares de cancro de mama por micro-espectroscopia de Raman
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2020/02 - 2020/07 Identificação de biomarcadores espectrais em linhas celulares de cancro de mama por micro-espectroscopia de FTIR
Supervisor
 Chemistry (Degree)
Universidade de Coimbra Departamento de Química, Portugal
2019 - 2019 Poder antioxidante da Corema album
Supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018 Valorização da planta halófita Salicornia ramosissima: nova formulação de bolachas e outros estudos biológicos
Co-supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018 A contribution to the valorisation of a marine plant: Corema album
Co-supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2018 - 2018 Efeitos do Crómio Hexavalente em Células Epiteliais de Pulmão Humano
Co-supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2017 - 2017 Desenvolvimento de Agentes Quimiopreventivos e Quimioterapêuticos (de Pt (II)e Pd(II)) – Estudo por Espectroscopia Vibracional e Ensaios de Biologia Celular
Co-supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2017 - 2017 Ensaios de Avaliação da Atividade Biológica de Compostos Fenólicos em Células Tumurais Humanas
Co-supervisor
Unidade I&D Química-Físicia Molecular, Portugal
2016 - 2016 Enhancement of wine antioxidant capacity by development of an innovative production methodology - new insights on the in vitro anthocyanin gut absorption
Co-supervisor
 Técnicas de Cultura Celular (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico)
Supervisor
 Cursos de Verão da Universidade de Coimbra (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico)
Supervisor
 Cursos de Verão da Universidade de Coimbra (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico)
Supervisor
 Cursos de Verão da Universidade de Coimbra (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Estudos de Caracterização Estrutural e Avaliação das Propriedades Biológicas de Compostos com Potencial Aplicação em Medicina (terapia e diagnóstico)
Supervisor
 Cursos de Verão da Universidade de Coimbra (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Correlating Biological Activity and Chemical Fingerprint: Raman Microspectroscopy Studies in Human Breast Cancer Cells
Supervisor
 Bioquímica (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2014 - 2014 Anti-angiogenic Properties of a Palladium Derivative Compound: Pd2Spm
Supervisor
 Técnicas de manipulação de CAM (Other)
Universidade do Porto, Portugal
2013 - 2013 A Novel Integration Approach:Perturbation Studies in Vitro using PDK1/Akt Inhibitor in Glioblastoma Multiforme
Supervisor
 Técnicas de Cultura Celular (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2013 - 2013 Olive Oil Components as Potential Chemopreventive Agents Against Cancer - Cell Biology Studies
Supervisor
 Técnicas de Cultura Celular (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2012 - 2012 Phytochemicals as Chemopreventive Agents Towards Cancer - Structure-Activity Relationships
Supervisor
 Técnicas de Cultura Celular (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2012 - 2012 A Microespectroscopia Raman como Biosensor - Aplicação em Células Humanas
Supervisor
 Técnicas de Espectroscopia Vibracional (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2011 - 2011 Phytochemicals from Olive Oil as Cancer Chemopreventive Agents
Supervisor
 Técnicas de Cultura Celular (Other)
Unidade I&D Química-Físicia Molecular, Portugal
2010 - 2010 Complexos de Pt(II) e Pd(II) com Poliaminas como Potenciais Agentes Anticancerígenos
Supervisor
 Biochemistry (Master)
Unidade I&D Química-Físicia Molecular, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/03/14 - 2019/03/14 5º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2019/03/14)
Workshop (Member of the Organising Committee)
 Neutron and Muon Users in Portugal (NeMPo), Portugal
2018/10/10 - 2018/10/12 Summer School of the COST-BM1401 - Raman-based Applications for Clinical Diagnostics (Raman4Clinics) (2018/10/10 - 2018/10/12)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2018/10/07 - 2018/10/09 Meeting of the COST-BM1401 - Raman-based Applications for Clinical Diagnostics (Raman4Clinics) (2018/10/07 - 2018/10/09)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2017/11/20 - 2017/11/20 2º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2017/11/20 - 2017/11/20)
Workshop (Member of the Organising Committee)
 Neutron and Muon Users in Portugal (NeMPo), Portugal
2017/05/31 - 2017/05/31 1º Workshop do Núcleo de Utilizadores Portugueses de Neutrões&Muões (2017/05/31 - 2017/05/31)
Workshop (Member of the Organising Committee)
 Neutron and Muon Users in Portugal (NeMPo), Portugal
2011/08/29 - 2011/09/03 XIV European Conference on the Spectroscopy of Biological Molecules (ECSBM 14) (2011/08/29 - 2011/09/03)
Conference (Member of the Organising Committee)
2009/04/18 - 2009/04/19 Jornadas Científicas - 30º Aniversário da Licenciatura em Bioquímica (2009/04/18 - 2009/04/19)
Conference (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2008/04/24 - 2008/04/25 III Encontro Nacional de Estudantes de Bioquímica (ENEBIOQ) (2008/04/24 - 2008/04/25)
Meeting (Member of the Organising Committee)
 Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018 - 2023 Iniciativa da Secretaria de Estado da Educação, através da Rede de Bibliotecas Escolares e da Secretaria de Estado da Ciência, Tecnologia e Ensino Superior. "Novos Medicamentos para o Tratamento do Cancro" Palestra na escola Secundária Quinta das Flores. Demonstrações laboratoriais (hands-on) na área da Química Medicinal, para alunos do ensino secundário.
Exhibition
 Programa Cientificamente Provável
Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2022 - 2022 –Palestra, workshop e visita aos laboratórios da Unidade de I&D Química-Física Molecular com demonstrações do tipo de investigação realizadas no âmbito da utilização de espetroscopia vibracional
Exhibition
 Semana da Ciência e da Tecnologia
Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2021 - 2021 Dia Aberto da Unidade de I&D Química-Física Molecular - Visita aos laboratórios da Unidade de I&D Química-Física Molecular com demonstrações do tipo de investigação realizadas no âmbito da utilização de espetroscopia vibracional.
Exhibition
 Semana da Ciência e da Tecnologia
Universidade de Coimbra Unidade de Investigacao e Desenvolvimento Quimica-Fisica Molecular, Portugal
2019 - 2019 Demonstrações laboratoriais (hands-on) na área da Química Medicinal
Exhibition
Escola Secundária José Falcão , Portugal
2019 - 2019 Poluição ambiental por metais: determinação por espectrofotometria de absorção molecular no visível
Workshop
 Encontro de Ensino e Divulgação da Química da Sociedade Portuguesa de Química
Sociedade Portuguesa de Química, Portugal
2018 - 2018 Ocupação científica de jovens nas férias - com actividades laboratoriais e de campo relativas ao estudo de compostos extraídos das plantas (endógenas da região Centro de Portugal) com propriedades benéficas para a saúde. (http://www.cienciaviva.pt/estagios/jovens/ocjf2018/)
Exhibition
 Ciência Viva no Laboratório (FCT)
Fundação para a Ciência e a Tecnologia, Portugal
2015 - 2018 Demonstrações laboratoriais (hands-on) na área da Química Medicinal e Bioquímica
Exhibition
 Universidade de Verão
Centro Hospitalar e Universitario de Coimbra EPE Centro de Simulação Biomédica dos Hospitais da Universidade de Coimbra, Portugal
2017 - 2017 Ocupação científica de jovens nas férias - com actividades laboratoriais e de campo relativas a: (i) estudo de compostos extraídos das plantas com propriedades benéficas para a saúde; (ii) desenvolvimento de novos fármacos (ex. anticancerígenos). (http://www.cienciaviva.pt/estagios/jovens/ocjf2017/)
Exhibition
 Ciência Viva no Laboratório (FCT)
Fundação para a Ciência e a Tecnologia, Portugal
2017 - 2017 Divulgar a ciência que se faz nos centros de investigação da FCTUC, promovendo uma literacia científica
Exhibition
 1ª Mostra de Ciência
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Apresentações teóricas e demonstrações experimentais na área da Quimioprevenção e Quimioterapia, promovida pela Comissão Europeia no âmbito das Ações Marie Curie. Noite Europeia dos Investigadores (Researchers´ Night)
Universidade de Coimbra, Portugal
2015 - 2015 Apresentações teóricas e demonstrações computacionais na área da Química/Desenvolvimento de Fármacos Anticancerígenos, promovida pela Comissão Europeia no âmbito das Ações Marie Curie. Noite Europeia dos Investigadores (Researchers´ Night)
Universidade de Coimbra, Portugal
2015 - 2015 Visita aos laboratórios da Unidade de I&D Química-Física Molecular e demonstrações práticas para alunos dos ensinos básico e secundário de Escolas do distrito de Coimbra Semana da Ciência e Tecnologia do Museu da Ciência da Universidade de Coimbra
Universidade de Coimbra, Portugal
2009 - 2009 Seminários teóricos e atividades laboratoriais para alunos do ensino secundário, organizado pelo Núcleo de Estudantes de Bioquímica da Associação da Académica de Coimbra (NEBIOQ).
Exhibition
 Dia aberto da Bioquímica
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023 Desenvolvimento de Novos Agentes Anticancerígenos com Pd(II) Contra o Cancro do Cólon - Estudo por Microespetroscopia Vibracional
Supervisor
 Bruna Queiroz de Brito (Other)
Universidade de Coimbra, Portugal
2023 New Drugs to Fight Osteosarcoma - A Complete Vibrational Microscpectroscopy Study
Supervisor
 Raquel Cadete Laginha da Silva (Master)
Universidade de Coimbra, Portugal
2022 Impact of Adenosine on Sensitivity of Triple Negative Breast Cancer Cells Towards Platinum-Derived Chemotherapeutic Drugs
(Thesis) Arguer
 Ana Sofia Silva Cerquido (Master)
Universidade do Porto, Portugal
2021 Avaliação do impacto metabólico de complexo de Pd-(II) em linha celular de cancro da próstata por microespectroscopia de FTIR
Supervisor
 Raquel Cadete Laginha da Silva (Other)
Universidade de Coimbra, Portugal
2021 Avaliação do impacto metabólico de complexo de Pd-(II) em linha celular de cancro da próstata por microespetroscopia de Raman
Supervisor
 Beatriz Rodrigues (Other)
Universidade de Coimbra, Portugal
2018 Desenvolvimento de Estratégias para a Valorização de uma Planta Endógena da Costa Marítima Portuguesa: a Corema album (L.) D. Don
(Thesis) Arguer
 Luís Miguel da Silva Simões (Master)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2018 Multiplicação e Estabelecimento in vitro e ex vitro de Salicornia ramosissima
(Thesis) Arguer
 Marta Susana da Silva Clemente (Master)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Association member

Society Organization name Role
2020 - Current Associação miniBIOQS - Associação Ciência para Todos Secretária do Conselho Fiscal
2018 - Current Grupo Português de Utilizadores de Neutrões e Muões (NeMPo)
2016 - Current Royal Society of Chemistry
2016 - Current Clirspec
2010 - Current Portuguese Society of Biochemistry
2020 - 2021 Projeto Student Keep Voluntária

Conference scientific committee

Conference name Conference host
2020/02/19 - 2020/02/20 V Encontro Científico do NEQ/AAC Núcleo de Estudantes de Química da Associação Académica de Coimbra (NEQ/AAC)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Tuturial em Química Química (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2021/02 - Current Estrutura e Modelação de Biomacromoléculas Química Medicinal (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2021 - Current Desenvolvimento de Fármacos II Química Medicinal (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2021 - Current Iniciação à Investigação e Desenvolvimento Química (Mestrado) Universidade de Coimbra Departamento de Química, Portugal
2020/02 - Current Estágio Laboratorial Química (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2019/09 - Current Química Biológica Química/Química Medicinal (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal
2020/03 - 2020/07 Laboratórios de Química II Química/Química Medicinal (Licenciatura) Universidade de Coimbra Departamento de Química, Portugal

Mentoring / Tutoring

Topic Student name
2023/07 - 2023/09 Avaliação da citotoxicidade de complexos metálicos de Pd(II) e Pt(II) em linha celular de cancro de colon Sabrina Louise Lopes Pereira
2023/07 - 2023/09 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de colon por microespectroscopia de Raman Mariana Isabel Breia Silva
2023/06 - 2023/09 Avaliação da citotoxicidade de complexos metálicos de Pd(II) e Pt(II) em linha celular de cancro de mama Rita Maria Marrazes Fernandes
2023/08 - 2023/08 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de colon por microespectroscopias de Infravermelho João Fernando de Sousa Henriques
2022/06 - 2022/09 Avaliação do efeito citotóxico de complexos metálicos de Pd(II) e Pt(II) em linha celular de pulmão (não tumorais) Rita Maria Marrazes Fernandes
2022/06 - 2022/07 Novos métodos de diagnóstico de rejeição hepática pós transplantação - espectroscopia vibracional Catarina Alcobia Montargil
2020/09 - 2021/12 Synthesis and Characterization of a Biocompatible Fluorinated Mn(III)-Porphyrin as a Redox Responsive 19F-NMR/T1 Bimodal MRI Contrast Agent Ana Rita Rolo Ferreira
2021/06 - 2021/09 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais) por microespectroscopias de Raman e Infravermelho Raquel Cadete Laginha da Silva
2021/07 - 2021/08 Avaliação da atividade citotóxica e citoestática de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais Carolina dos Santos Neto
2021/07 - 2021/08 Avaliação da resposta quimioterapêutica de complexos metálicos de Pd(II) e Pt(II) em linhas celulares de próstata (tumorais e não tumorais) por microespectroscopias de Raman e Infravermelho Inês Gonçalves Cruz
2019/08 - 2019/08 Caracterização de Linhas Celulares de Mama por Microespetroscopia de Raman Bárbara Lima

Scientific expedition

Activity description Institution / Organization
2024/09 - 2024/09 Probing Metallodrug Action on Human Cancer Cells by QSM ISIS@MACH ITALIA, Italy
2024/02 - 2024/02 Probing drug pharmacokinetics by QENS. The effect of cisplatin-like anticancer agents on HSA blood protein Institut Laue–Langevin, France
2023/12 - 2023/12 Experiment SM34458: "THz Spectroscopy - an Unmet Approach to Study DNA Interaction in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol" Diamond Light Source Ltd, United Kingdom
2023/05 - 2023/05 Experiment SM33051: "Impact of Metallogrugs on Cellular Membrane Lipids Probed by Combined SR-Infrared Spectroscopy and Neutron Scattering" Diamond Light Source Ltd, United Kingdom
2022/04 - 2022/04 Experiment SM32861: "Thriving Advantages of Drug Combination in Osteosarcoma Treatment: Pt(II) and Pd(II) Complexes Application According to the EURAMOS-1 Protocol" Diamond Light Source Ltd, United Kingdom
2022/04 - 2022/04 Experiment SM26320: "An Enhanced Insight of Cell Response to Anticancer Drugs by AFM-IR Nanospectroscopy" Diamond Light Source Ltd, United Kingdom
2022/01 - 2022/01 Experiment SM29925: "SR-FTIR Microspectroscopy of Live Single Cells to Probe Anticancer Drug Action" Diamond Light Source Ltd, United Kingdom
2019 - 2019 Experiment SM21620: "Probing Chemoresistance to Pt- and Pd-Drugs via THz Spectroscopy" Diamond Light Source Ltd, United Kingdom
2018/10 - 2018/10 Experiment SM19692: "Combined Quasi-elastic Neutron Scattering and SR-Infrared Microspectroscopy for Improving Chemotherapeutic Success Against Osteosarcoma" Diamond Light Source Ltd, United Kingdom
2018/05 - 2018/05 Experiment SP18498: "An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs" Diamond Light Source Ltd, United Kingdom
2017/05 - 2017/05 Experiment SP16058: "An EXAFS Approach to the Pharmacodynamics of Unconventional Pt- and Pd-Based Anticancer Drugs" Diamond Light Source Ltd, United Kingdom
2017/02 - 2017/02 Experiment SM14895: "Probing Polynuclear Cisplatin-like Agents Activity on DNA via Thz Spectroscopy Diamond Light Source Ltd, United Kingdom
2016 - 2016 Experiment SM13726: "Infrared Signature of Drug Action at the Single Cell Level - Cisplatin-Like Agents. SR-FTIR Imaging via FPA on Human Breast Cancer Cells" Diamond Light Source Ltd, United Kingdom
2015 - 2015 Experiment SM10065: "SR-IR Signature of Drug Action at Single Cell Level - Novel Cisplatin-like Agents" Diamond Light Source Ltd, United Kingdom
Distinctions

Other distinction

2024 ISIS Highlight - How water dynamics could be a new cancer biomarker
ISIS Pulsed Neutron and Muon Source, United Kingdom
2021 ISIS Highlight - Human Tissue Measured for the First Time using QENS
ISIS Pulsed Neutron and Muon Source, United Kingdom
2020 ISIS Highlight - Intracellular water could help us distinguish between healthy and malignant cells
ISIS Pulsed Neutron and Muon Source, United Kingdom
2019 ISIS Highlight - Anticancer Drug Impact on DNA: a Study by Neutron Spectroscopy Coupled with Synchrotron-based FTIR and EXAFS
ISIS Pulsed Neutron and Muon Source, United Kingdom
2019 PCCP HOT Articles/Editor choice for themed collection 2019 - Anticancer Drug Impact on DNA: A Study by Neutron Spectroscopy coupled to Synchrotron-based FTIR and EXAFS
2019 ISIS Neutron & Muon Source Impact Award 2019 - Public Engagement & Society, "Shining the Beam on Cells category - Intracellular Water as a Mediator of Anticancer Drug Action"
ISIS Pulsed Neutron and Muon Source, United Kingdom
2017 ISIS Highlight - Intracellular Water - an Overlooked Cancer Drug Target
ISIS Pulsed Neutron and Muon Source, United Kingdom
2017 Diamond Highlight - Probing Polynuclear Cisplatin-like Agents Activity on DNA via THz Spectroscopy
Diamond Light Source Ltd, United Kingdom