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João Trigueiro-Louro (JTL) is a Medical Doctor (NOVA Medical School), working as general practitioner; and a Pharmacist (FFUL). JTL has also a PhD. in Pharmacy (Microbiology), with experience in R&D in the field of influenza virus and coronavirus. He has been collaborating with HRA team in several projects with respect to the susceptibility of influenza virus and coronavirus to antiviral drugs; evolution of influenza viruses; molecular determinants of influenza pathogenesis; and exploring new influenza, coronavirus and flavivirus targets and their role on viral replication. During and following his PhD, JTL has been dedicated to discover and validate novel influenza and SARS-CoV-2 targets for antiviral development, holding strong expertise in large sequence data treatment and analysis; in computational tools (e.g. machine learning) for structural characterization of viral targets; and on viral infection experiments. During COVID-19 pandemic, JTL has also collaborated as volunteer consultant in the COVID-19 Task Force (DGS). JTL has also experience in pharmaceutical industry (pharmacovigilance). JTL is author and coauthor of 10 scientific publications in the field of influenza and coronavirus; and presenter of more than 10 oral communications, from which he has won three awards regarding best scientific communication. JTL has been co-supervisor of 3 Master projects at Faculty of Pharmacy, University of Lisbon.
Identification

Personal identification

Full name
João Trigueiro-Louro

Citation names

  • Trigueiro-Louro, João

Author identifiers

Ciência ID
4418-D8DC-249A
ORCID iD
0000-0003-0384-5319

Email addresses

  • joao.louro@insa.min-saude.pt (Professional)
  • jlouro@chlo.min-saude.pt (Professional)

Addresses

  • Instituto Nacional de Saúde Doutor Ricardo Jorge, IP. Avenida Padre Cruz, 1649-016, Lisboa, Lisboa, Portugal (Professional)
  • Hospital de São Francisco Xavier, Estr. Forte do Alto Duque , 1449-005, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Virology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Clinical Medicine - General and Internal Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2017/01/01 - 2022/05/05
Concluded
Doutoramento em Farmácia (Doutoramento)
Major in Microbiologia
Universidade de Lisboa Faculdade de Farmácia, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
"Conserved proteins of influenza virus and coronavirus as emerging therapeutic targets" (THESIS/DISSERTATION)
Approved with Distinction and Honours
2022
Concluded
Basic Life Support (Outros)
Centro Hospitalar de Lisboa Ocidental EPE, Portugal
2015/09/01 - 2021/06/01
Concluded
Mestrado Integrado em Medicina (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
17
2020
Concluded
TEAM (Trauma Evaluation and Management) Course (Outros)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017
Concluded
Pharmacovigilance and Drug Safety Course (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
17
2014
Concluded
Integrated Masters in Pharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Susceptibility of influenza A virus to antiviral drugs. Targeting the NS1 dealer as a new anti-influenza virus strategy." (THESIS/DISSERTATION)
16 (0-20 grading scale)
Affiliation

Science

Category
Host institution
Employer
2015/02/14 - Current Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2020 - 2020 Visiting Researcher (Research) Direção-Geral da Saúde, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2021 - 2024 Tutor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Other Careers

Category
Host institution
Employer
2022/01/01 - Current Interno (Médica) Centro Hospitalar de Lisboa Ocidental EPE, Portugal
Centro Hospitalar de Lisboa Ocidental EPE, Portugal

Others

Category
Host institution
Employer
2015/01/15 - Current Research collaborator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/01/01 - 2021/02/28 Ph.D. Candidate: Ph.D. Programme in Medicines and Pharmaceutical Innovation (i3DU). Title: Novel antivirals against Influenza: Targeting the NS1 dealer as an emerging therapeutic target Tutor: Prof. Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2017/01/01 - 2017/12/01 Invited assistant - Public Health Universidade Lusófona de Humanidades e Tecnologias, Portugal
2016/06/01 - 2016/12/30 Health Care Compliance Integrity Intern Tutors: José Antunes (Medical director) and Ana Marta Cunha HCBIO) Janssen-Cilag Farmacêutica Lda, Portugal
2015/10/01 - 2016/06/30 Associate fellow (ref:2015DDI1232) Project:New antivirals and new brands: Phenotypic susceptibility profiles of influenza virus to the new NAIs and cost-efficient alternative solutions for neuraminida Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2015/04/07 - 2015/09/30 Research grant holder Ref.PID/HPI/2015/002 Project: “Functional compatibility of the replication complex as a determinant of virulence in influenza for vaccine production”-FCT Tutors: Prof Dr. José Az Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/02/13 - 2014/12/15 Research student at Host-Pathogen Interaction Unit Advisor: Prof. Dr. Helena Rebelo de Andrade Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/06/02 - 2014/07/31 Curricular Training in a Hospital Supervisor: Dr. Margarida Freitas Hospital CUF Descobertas, Portugal
2014/03/03 - 2014/05/30 Research trainee within Public Health England Advisors: Dr. Angie Lackenby and Joanna Ellis Public Health England, United Kingdom
2013/09/02 - 2013/09/30 Scientific research at Department of Bioinorganic Chemistry. Advisor: Dr. Justyn Ochocki Uniwersytet Medyczny w Lodzi Wydzial Lekarski, Poland
Projects

Contract

Designation Funders
2023/02/01 - Current Delivering a Unified Research Alliance of Biomedical and public health Laboratories against Epidemics (DURABLE) 101102733
101102733
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Ongoing
2018/09/01 - 2021/08/31 Reverse Genetics Vaccine Seeds for Influenza: Mechanisms that drive the co-segregation of PB1 with antigenic proteins
PTDC/SAU-INF/30729/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Concluded
2018/09/01 - 2021/07/31 Novel antivirals against Influenza: NS1 target validation and lead discovery
PTDC/QUI-OUT/32572/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
Concluded
2019/01/01 - 2019/12/31 Research Institute for Medicines
UID/DTP/04138/2019
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Trigueiro-Louro, João; Rebelo-de-Andrade, Helena. "Diagnóstico Laboratorial da Gripe". In Manual Sobre gripe, 125-170. lisboa, Portugal: Lidel, 2018.
    Published
Conference poster
  1. Trigueiro-Louro, João; Figueiredo-Nunes, Inês; Santos, Luís A.; Almeida, Filipe; Correia, Vanessa; Guedes, Rita C.; Brito, Rui M.M.; Rebelo-de-Andrade, Helena. "Exploring influenza A and B therapeutics: NS1 as a potential universal antiviral target". Paper presented in The seventh ESWI Influenza Conference, Virtual Edition, 2020.
  2. Trigueiro-Louro, João; Santos, Luís A.; Almeida, Filipe; Correia, Vanessa; Brito, Rui M.M.; Rebelo-de-Andrade, Helena. "NS1 as a promising anti-influenza target: new putative druggable hot spots and their relevance on viral replication". Paper presented in The seventh ESWI Influenza Conference, Virtual Edition, 2020.
  3. Trigueiro-Louro, João; Correia, Vanessa; Figueiredo-Nunes, Inês; Gíria, Marta; Rebelo-de-Andrade, Helena. "Exploring coronavirus locks: Sequence-to-structure characterization of SARS-CoV-2, SARS-CoV and MERS-CoV proteins". Paper presented in The seventh ESWI Influenza Conference, Virtual Edition, 2020.
  4. Figueiredo-Nunes, Inês; Trigueiro-Louro, João; Correia, Vanessa; Gíria, Marta; Rebelo-de-Andrade, Helena. "Exploring antiviral strategies against a broad range of beta-CoVs: Spike and Polymerase proteins as promising anti-CoV targets". Paper presented in Special isirv-AVG Virtual Conference on ¿Therapeutics for COVID-19¿, 2020.
  5. Santos L.A.; Almeida F.; Trigueiro-Louro J.; Rebelo-de-Andrade H. "Cosegregation of influenza A A/H1N1pdm09 PB1 and glycoproteins HA and NA as a determinant factor for antigen yield". Paper presented in Seventh ESWI Influenza and COVID-19 Conference. Virtual Edition., 2020.
  6. Trigueiro-Louro, João. "PB1-HA functional compatibility contributes to genome segregation patterns and to the overall viral fitness in A(H1N1)pdm09 vaccine seeds.". Paper presented in OPTIONS X for the control of influenza Conference, 2019.
  7. Trigueiro-Louro, João. "Exploiting lineage-specificity of influenza B virus neuraminidase inhibitor natural susceptibility and selective pressure strength at resistance-associated sites.". Paper presented in OPTIONS X for the control of influenza Conference. Singapore, 2019.
  8. Trigueiro-Louro, João. "Unlocking the antiviral target potential of influenza A virus NS1 protein". Paper presented in OPTIONS X for the control of influenza Conference., 2019.
  9. Correia, Vanessa; Santos, Luís A.; Trigueiro-Louro, João; Abecasis, Ana; Rebelo-de-Andrade, Helena. "Victoria and Yamagata: Exploiting lineage-specificity of influenza B virus neuraminidase inhibitor natural susceptibility and selective pressure strength at resistance-associated sites". Paper presented in OPTIONS X for the Control of Influenza, 2019.
  10. Trigueiro-Louro, João. "Na rota dos descobrimentos de novos alvos antivirais contra a gripe - Mapeamento computacional do domínio efetor da proteína NS1.". Paper presented in V Congresso Nacional de Virologia, 2018.
  11. Trigueiro-Louro, João. "A cost-efficient solution: reagent comparison guide for neuraminidase inhibition assay". Paper presented in 19th Annual Meeting of the European Society for Clinical Virology, 2016.
Journal article
  1. Santos, Luís A.; Almeida, Filipe; Gíria, Marta; Trigueiro-Louro, João; Rebelo-de-Andrade, Helena. "Adaptive evolution of PB1 from influenza A(H1N1)pdm09 virus towards an enhanced fitness". Virology 578 (2023): 1-6. http://dx.doi.org/10.1016/j.virol.2022.11.003.
    10.1016/j.virol.2022.11.003
  2. Figueiredo-Nunes, Inês; Trigueiro-Louro, João; Rebelo-de-Andrade, Helena. "Exploring new antiviral targets for influenza and COVID-19: Mapping promising hot spots in viral RNA polymerases". Virology 578 (2023): 45-60. http://dx.doi.org/10.1016/j.virol.2022.11.001.
    10.1016/j.virol.2022.11.001
  3. Almeida, Filipe; Santos, Luís A.; Trigueiro-Louro, João M.; Rebelo-de-Andrade, Helena. "Optimization of A(H1N1)pdm09 vaccine seed viruses: The source of PB1 and HA vRNA as a major determinant for antigen yield". Virus Research 315 (2022): 198795. http://dx.doi.org/10.1016/j.virusres.2022.198795.
    10.1016/j.virusres.2022.198795
  4. David, Susana; Dorado, Guillermo; Duarte, Elsa L.; David-Bosne, Stephanie; Trigueiro-Louro, João; Rebelo-de-Andrade, Helena. "COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity". Immunogenetics 74 4 (2022): 381-407. http://dx.doi.org/10.1007/s00251-022-01261-w.
    10.1007/s00251-022-01261-w
  5. Trigueiro-Louro, João; Santos, Luís; Almeida, Filipe; Correia, Vanessa; Brito, Rui; Rebelo-de-Andrade, Helena. Corresponding author: Trigueiro-Louro, João. "NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral replication". Virology 565 (2022): 106-116. http://dx.doi.org/10.1016/j.virol.2021.11.001.
    10.1016/j.virol.2021.11.001
  6. Trigueiro-Louro, João; Correia, Vanessa; Figueiredo-Nunes, Inês; Gíria, Marta; Rebelo-de-Andrade, Helena. Corresponding author: Rebelo-de-Andrade, Helena. "Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike". Computational and Structural Biotechnology Journal 18 (2020): 2117-2131. https://doi.org/10.1016/j.csbj.2020.07.017.
    10.1016/j.csbj.2020.07.017
  7. Trigueiro-Louro, J.M.; Correia, V.; Santos, L.A.; Guedes, R.C.; Brito, R.M.M.; Rebelo-de-Andrade, H.. "To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential". Virology 535 (2019): 297-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070696556&partnerID=MN8TOARS.
    10.1016/j.virol.2019.04.009
  8. Gíria, M.; Santos, L.; Louro, J.; Rebelo de Andrade, H.. "Reverse genetics vaccine seeds for influenza: Proof of concept in the source of PB1 as a determinant factor in virus growth and antigen yield". Virology 496 (2016): 21-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969785437&partnerID=MN8TOARS.
    10.1016/j.virol.2016.05.015
Thesis / Dissertation
  1. "Conserved proteins of influenza virus and coronavirus as potential novel therapeutic targets". PhD, Universidade de Lisboa Faculdade de Farmácia, 2022. http://hdl.handle.net/10451/54912.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/08 Exploring the NS5 protein of dengue virus as a novel antiviral target DURABLE annual meeting
DURABLE (Roterdam, Netherlands)
2020/10/04 Current status of vaccine development. COVID-19 panel Infection and Sepsis Symposium
Grupo de Investigação e Desenvolvimento em Infeção e Sepsis (Porto, Portugal)
2019/10/04 Tratamento e Medidas de Prevenção no quesito Gripe X Jornadas de Ciências da Saúde. X Jornadas de Ciências da Saúde
Instituto Universitário Egas Moniz (Almada, Portugal)
2019/04/10 Tratamento e Medidas de Prevenção no quesito Gripe X Jornadas de Ciências da Saúde
Instituto Universitário Egas Moniz (Lisboa, Portugal)
2014/05/28 A non-infectious transfection system for expression of a non-human neuraminidase Virus Reference Department (VRD) Seminar
Public Health England, Colindale, United Kingdom (London, United Kingdom)
2014/05/28 Characterization of influenza A(H1N1)pdm09 viruses in original material from portuguese clinical samples Virus Reference Department (VRD) Seminar
Public Health England (London, United Kingdom)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023 - Current Exploring proteins of dengue virus as novel antiviral targets
Co-supervisor
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Current Exploring the NS5 protein of dengue virus as a novel antiviral target
Co-supervisor
Mestrado Integrado em Ciências Farmacêuticas (Scientific initiation)
2020/04/04 - 2020/12/01 Novas estratégias terapêuticas contra proteínas conservadas do vírus influenza - Final Monograph
Co-supervisor
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/13 - 2020/01/25 ProjectII: Influenza A and B virus NS1 protein as a potential therapeutic target
Co-supervisor
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/10/04 - 2019/06/06 Project I: Influenza B virus NS1 protein as a potential therapeutic target
Co-supervisor of Inês Figueiredo Nunes
Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Consulting

Activity description Institution / Organization
2022 - 2022 Webinar - Antivirais Orais para o tratamento da COVID-19 Pfizer Portugal, Portugal
2020/04/01 - 2020/10/31 Volunteer Consultant in Virology General Directorate of Health, Lisbon Portugal (COVID-19 Task Force) SARS-CoV-2 virology and Public Health control measures for COVID-19 Direção-Geral da Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/04/16 - 2021/04/16 Bioinformatic tools for the identification of emerging therapeutic targets (early drug discovery) Curso: Infeções Emergentes de Etiologia Vírica. Mestrado em Ciências Biofarmacêuticas. Lisboa (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2020 Young Scientist Award

Other distinction

2017 Ph.D. fellowship
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal