???global.info.a_carregar???
Marco Serafini is a PhD candidate at the Faculty of Pharmacy of the University of Lisbon. He obtained his Master's Degree in Pharmaceutical Chemistry and Technology in 2020 in the Department of Pharmacy of University of Pisa, Italy. During his master thesis, he was involved in a project focused on drug discovery of new selective thyromimetics with potential therapeutic use, under the supervision of Professor Simona Rapposelli. In particular, he synthetized new small molecules based on the diphenylmethane scaffold for the treatment of liver disease such as NASH and NAFLD. Additionally, as part of his work, he managed the assesment of the ADME-Tox profile and the effects on autophagic flux of these molecules by using both biochemical and cell-based assays, at the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Hamburg, Germany, under the supervision of Dr. Sheraz Gul. During his stay at the Fraunhofer, he had the opportunity to develop skills in cell cultures and in the use of tools and equipment employed for High-Throughput and High-Content Screening, including Echo 550 Liquid Handler (Labcyte) and Envision 2100 Multilabel Reader (PerkinElmer). After his graduation, he performed a research trainee at Research Institute for Medicines (iMed.ULisboa) at the faculty of Pharmacy of University of Lisbon under the supervision of Professor Rui Moreira and Francisca Lopes, where he managed the development of novel indole-based drug leads for the treatment of Tuberculosis and the synthesis of four membered ring scaffolds. Throughout his research experience, Marco acquired several skills in organic synthesis, analytical techniques and biological assays.
Identification

Personal identification

Full name
Marco Serafini

Citation names

  • Serafini, Marco

Author identifiers

Ciência ID
4317-F7C8-DF0E
ORCID iD
0000-0003-4687-2640

Email addresses

  • marco.serafini.55ms@gmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Italian (Mother tongue)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2013/09/30 - 2020/03/04
Concluded
Pharmaceutical Chemistry and Technology (Master)
Università degli Studi di Pisa Dipartimento di Farmacia, Italy
"Synthesis and biological evaluation of novel TR-beta selective agonists sustained by ADME-toxicity analysis" (THESIS/DISSERTATION)
110/110 cum laude
Affiliation

Science

Category
Host institution
Employer
2020/09/15 - 2021/03/15 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/10/01 - 2019/12/31 Research Trainee (Research) Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port (IME SP), Germany
Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port (IME SP), Germany
2019/04/01 - 2019/09/25 Research Trainee (Research) Università degli Studi di Pisa Dipartimento di Farmacia, Italy
Università degli Studi di Pisa Dipartimento di Farmacia, Italy

Others

Category
Host institution
Employer
2018/09/03 - 2019/03/05 Student Trainee Farmacia Novelli, Italy
Projects

Grant

Designation Funders
2019 - 2019/12/18 In vitro screening for autophagic promotion and ADME-Toxicity features of new small molecules
279999_2019
Master Student Fellow
Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port (IME SP), Germany
Università degli Studi di Pisa
Concluded

Contract

Designation Funders
2020 - 2021/03/14 Synthetic Approaches to Novel Antimycobacterial and Antimalarial Compounds
487/2020
Erasmus Traineeship
Universidade de Lisboa Faculdade de Farmácia, Portugal
Università degli Studi di Pisa
Concluded
Outputs

Publications

Thesis / Dissertation
  1. Serafini, Marco. "Synthesis and biological evaluation of novel TR-beta selective agonists sustained by ADME-toxicity analysis". Master, Università degli Studi di Pisa Dipartimento di Farmacia, 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/03/04 Development of new drug leads for Tuberculosis Lab Meeting
iMed.ULisboa, Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)
2021/02/11 AUTACs: Cargo-Specific Degraders Using Selective Autophagy Lab Meeting
iMed.ULisboa, Faculty of Pharmacy, University of Lisbon (Lisbon, Portugal)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/01/28 - 2021/01/28 6th EFMC-YSN MedChemBioOnline - "PROTAC and Small Molecules Development" 6th EFMC-YSN MedChemBioOnline
2020/04/27 - 2020/04/30 MedChemTrain e-scool MedChemTrain e-school