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Paulo Jorge Gonçalves de Bettencourt. Concluiu o(a) Doutoramento em Farmácia em 2012/12/11 pelo(a) Universidade de Lisboa, Bacharelato em Biotecnologia em 1995 pelo(a) Grupo Lusófona e Master em Immunology and Immunogenetics em 2006 pelo(a) The University of Manchester Faculty of Biology Medicine and Health. É Professor Auxiliar no(a) Universidade Católica Portuguesa Faculdade de Medicina, Dirigente de laboratório, instituto, museu, centro ou observatório no(a) Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde e Membro do Conselho Científico da Faculdade de Medicina no(a) Universidade Católica Portuguesa. Publicou 35 artigos em revistas especializadas. Possui 3 capítulo(s) de livros. Participou em 21 evento(s). Coorientou 2 tese(s) de doutoramento. Orientou 7 dissertação(ões) de mestrado. Orientou 1 trabalho(s) de conclusão de curso de licenciatura/bacharelato e coorientou 1. Recebeu 9 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador Pós-doutorado em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Imunologia, Ciências Médicas e da Saúde com ênfase em Ciências da Saúde com ênfase em Doenças Infeciosas, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Microbiologia, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Molecular e Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Confocal microscopy; Intracellular bacteria; Teses de doutoramento - 2012; miRNA; microRNA; Mycobacterium tuberculosis; Macrophages; Host-pathogen interaction; Lipids; Vaccinologia; COVID-19; Vectores virais; ChAdOx-1; Vaccinology; Viral vectors; Immunopeptidomics; Antigen discovery; Host-pathogen interactions; Plasmodium falciparum; RNA interference; Caenorhabditis elegans; Mass spectrometry; Gene expression; Tuberculosis; Malaria; Mycobacteriology; Bacteriology ; Bacillus Calmette-Guérin; HIV/AIDS; Microbial Pathogenesis; Bacteriophages; HIV; Infectious diseases; RNA vaccines; Adjuvants and vaccines; Antigen processing and presentation; Bacterial infections; Infectious disease; MHC and polymorphic genes; imunopatologia; autoimunidade; linfopenia; celulas T reguladoras; HIV/SIDA; Patogenia microbiana; Bacteriófagos; phagocytosis; Rabs/SNARES; tráfego intracelular; filamentação da actina; microRNAs; maturação do fagossoma; sinais pró-inflamatórios; apresentação de antigénios; enzimas lizossomais; peptideos antimicrobianos; linfocitos; inflamação; doenças auto-imune; regulação; Diabetes tipo 1; TLR; Sistema imune inato; Genetica; Interferência por RNA ; Tumor microenvironment; Hypoxia-inducible factor; Factor-inhibiting HIF; B cell lymphoma; Tumor suppression; .
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Identification

Personal identification

Full name
Paulo Jorge Gonçalves de Bettencourt

Citation names

  • Bettencourt, Paulo
  • Bettencourt, P
  • Bettencourt, PJG

Author identifiers

Ciência ID
411F-ED5D-F52B
ORCID iD
0000-0002-4884-5470

Email addresses

  • pbettencourt@ucp.pt (Professional)

Addresses

  • Faculdade de Medicina, Universidade Católica Portuguesa, Estrada Octávio Pato, 2635-631, Rio de Mouro, Sintra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2012/12/11
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade de Lisboa, Portugal
"Role of Pro- and Anti-inflammatory Lipids in Intracellular Survival and Killing of Mycobacteria" (THESIS/DISSERTATION)
2006
Concluded
 Immunology and Immunogenetics (Master)
The University of Manchester Faculty of Biology Medicine and Health, United Kingdom
"Analysis of the Recombination Activating Genes 1 and 2" (THESIS/DISSERTATION)
1995
Concluded
 Biotecnologia (Bacharelato)
Grupo Lusófona, Portugal
Affiliation

Science

Category
Host institution 		Employer
2013/10/01 - 2020/12/31 Postdoc (Research) University of Oxford The Jenner Institute, United Kingdom
University of Oxford The Jenner Institute, United Kingdom
2007 - 2012 Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2007 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2001 - 2003 Researcher (Research) Cenix BioScience GmbH, Germany
Cenix BioScience GmbH, Germany
1996 - 1997 Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
1994 - 1995 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/01/01 - Current Assistant Professor (University Teacher) Universidade Católica Portuguesa Faculdade de Medicina, Portugal
Universidade Católica Portuguesa Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021/09/28 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
2021/04/22 - Current Membro do Conselho Científico da Faculdade de Medicina Universidade Católica Portuguesa, Portugal
2021/09/28 - 2023/09/25 Organic Unit Sub-director Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
2018 - 2020 Collection Responsible Officer, Human Tissue Act University of Oxford The Jenner Institute, United Kingdom
University of Oxford The Jenner Institute, United Kingdom

Others

Category
Host institution 		Employer
1998 - 2000 Empresário em nome individual Empresário em nome individual, Portugal
Projects

Grant

Designation Funders
2010/02 - 2013/07 Dissecting the intracelllular traffficking factors involved in M. tuberculosis killing/survival within human macrophages using RNA interference.
grant.Provided by PTCRIS: 98024
 Stichting Weten
2010/02 - 2013/07 Dissecação dos factores de tráfego intracelular envolvidos na morte /sobrevivência do M. tuberculosis em macrófagos humanos usando interferência por RNA.
Provided by PTCRIS: PTDC/SAU-MII/098024/2008
PTDC/SAU-MII/098024/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01 - 2012/06 Interferência do Mycobacterium tuberculosis com as vias endocíticas/apresentadoras de antigénios em macrófagos e células dendríticas de dadores saudáveis ou imunocomprometidos.
Provided by PTCRIS: PIC/IC/82859/2007
grant.Provided by PTCRIS: 82859
PIC/IC/82859/2007
 Fundação para a Ciência e a Tecnologia

Stichting Weten
Concluded
2007/09/01 - 2011/08/31 ROLE OF PRO- AND ANTI-INFLAMMATORY LIPIDS IN INTRACELLULAR SURVIVAL AND KILLING OF MYCOBACTERIA
SFRH/BD/32033/2006
Provided by PTCRIS: SFRH/BD/32033/2006
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2008/12 Genetics of the Innate Immune Response in the Non-Obese Diabetic Mouse
grant.Provided by PTCRIS: 83459
 Stichting Weten
2007/01 - 2008/12 Inflammatory components in the biology of regulatory T cells and the prevention of auto-immune disease
grant.Provided by PTCRIS: 82408
 Stichting Weten
2005/06 - 2007/07 Genetics of the Innate Immune Response in the Non-Obese Diabetic Mouse
grant.Provided by PTCRIS: 62964
 Stichting Weten
2005/06 - 2007/07 Inflammatory components in the biology of regulatory T cells and the prevention of auto-immune disease
grant.Provided by PTCRIS: 58192
 Stichting Weten
2005/06 - 2007/07 Componentes da inflamação na biologia de Células T reguladoras e na prevenção de doenças auto-imunes
Provided by PTCRIS: POCI/SAU-MMO/58192/2004
POCI/SAU-MMO/58192/2004
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1995/12 - 1997/11 EXTRACÇÃO, PURIFICAÇÃO E CARACTERIZAÇÃO DE LÍPIDOS DA PAREDE CELULAR DE MICOBACTÉRIAS
Provided by PTCRIS: PRAXIS XXI/BTL/6272/95
PRAXIS XXI/BTL/6272/95
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/07 - 2020/12/31 OptiMalVax: Optimizing a deployable high efficacy malaria vaccine
info:eu-repo/grantAgreement/NHMRC/International Collaborations/GNT1147654/AU
European Union's Horizon 2020 research and innovation programme under grant agreement No 733273
Post-doc
University of Oxford The Jenner Institute, United Kingdom
 National Health and Medical Research Council
Ongoing
2010/02/01 - 2013/07/31 Papel do M. tuberculosis no controlo por microRNAs da filamentação de actina e outros sinais pró-inflamatórios em macrófagos infectados.
PTDC/BIA-BCM/102123/2008
European Molecular Biology Laboratory, Germany
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 775 - 2011-2012
PEst-OE/SAU/UI0775/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09/01 - 2010/12/31 Repertório de receptores da célula T no geração e manutenção da tolerância imunológica: Requisitos qualitativos e quantitativos.
PTDC/SAU-MII/71402/2006
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/06/01 - 2007/07/31 Genética da resposta imune inata na diabetes tipo 1 murina
POCI/SAU-MMO/62964/2004
Provided by PTCRIS: POCI/SAU-MMO/62964/2004
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Barbosa, C.R.R.; Bettencourt, P.J.G.. "Harnessing the power of CD8+ T-cells: identification and validation of peptides bound to major histocompatibility complex class I by immunopeptidomics". 133-161. Elsevier, 2022.
    10.1016/b978-0-323-91146-7.00008-1
  2. Bettencourt, Paulo. "Mycobacterial infection of macrophages: the effect of the multiplicity of infection". In Antimicrobial Research: Novel Bioknowledge and Educational Programs; Méndez-Vilas, A., Ed, 651-664. Spain: Formatex, 2017.
    Published
  3. Bettencourt, Paulo; Pires, David; Carmo, Nuno; Anes, Elsa. "Application of confocal microscopy for quantification of intracellular mycobacteria in macrophages.". In Microscopy: Science, Technology, Applications and Education, 614-621. Spain: Formatex, 2010.
    Published
Conference poster
  1. Paulo Bettencourt. "MSc in immunology and vaccinology". 2024.
  2. Laura Matarazzo; Laura Taina-González; Ricardo Pinheiro; Pires D; María de la Fuente; Paulo Bettencourt. "New mRNA - nanoemulsions vaccine platform: application for Tuberculosis vaccine development". 2023.
  3. Paulo Bettencourt; Salem Almujri; Annalisa Nicastri; Rachel Tanner; Elena Stylianou; Iman Satti; Nicola Ternette; Helen McShane. "Identification of overlapping MHC-bound peptides presented by Mycobacterium tuberculosis and Mycobacterium bovis BCG infected cells using immunopeptidomics". 2023.
  4. Hugo Mateus; Ricardo Pinheiro; Hugo M. Santos; Paulo Bettencourt. "Identification of peptides presented by major histocompatibility complex in macrophages through immunopeptidomics". 2023.
  5. Ricardo Pinheiro; Cloé Abreu; Paulo Bettencourt. "Implementation of a pre-Good Laboratory Practice management system for academic research". 2023.
  6. Laura Matarazzo; Laura Taina-González; Ricardo Pinheiro; David Pires; Maria de la Fuente; Paulo Bettencourt. "Development of a new mRNA vaccine platform for tuberculosis". 2023.
  7. E. Stylianou; M. de la Fuente; H. McShane; Bettencourt, Paulo. "New platform for mRNA vaccines against tuberculosis". Paper presented in The Collaboration for TB Vaccine Discovery (CTVD) 8th Annual Meeting, at the Bill and Melinda Gates Foundation, Seattle, USA., 2022.
  8. Elena Stylianou; Maria de la Fuente; Helen McShane; Paulo Bettencourt. "New platform for mRNA vaccines against tuberculosis". 2022.
  9. Bettencourt, Paulo. "Immunopeptidomics-based identification of antigens presented by MHC-I and MHC-II for vaccines against tuberculosis". Paper presented in Keystone Symposia Conference on Tuberculosis: Immunity and Immune Evasion, Santa Fe, USA., 2020.
  10. Bettencourt, Paulo. "Using Immunopeptidomics and Immunoinformatics to Identify Novel Antigens for Subunit Vaccines for Tuberculosis". Paper presented in Keystone Symposia Conference on Tuberculosis: Science Aimed at Ending the Epidemic, Online, 2020.
  11. Bettencourt, Paulo. "Identifying T cell epitopes by Plasmodium vivax-infected reticulocyte immunopeptidomics". Paper presented in Malaria Gordon Research Seminar, Les Diablerets, Switzerland., 2019.
  12. Bettencourt, Paulo. "Identification of novel mycobacterial antigens presented by MHC-I and -II by immunopeptidomics for vaccines against tuberculosis". Paper presented in 17th International Congress of Immunology, Beijing, China., 2019.
  13. Bettencourt, Paulo. "Discovery of New Mycobacterial Antigens Using Mass Spectrometry". Paper presented in The Jenner Institute Student Symposium, Oxford, United Kingdom., 2019.
  14. Bettencourt, Paulo. "High throughput isolation of vaccine-grade malaria sporozoites from whole mosquitoes without dissection". Paper presented in 68th Annual Meeting of the ASTHM, National Harbor, USA., 2019.
  15. Paulo Bettencourt. "Antigen Discovery and Pre-Clinical Evaluation of Vaccines Against Tuberculosis". 2018.
  16. Bettencourt, Paulo. "Immunopeptidomics of BCG: A Novel Strategy for the Identification of Tuberculosis Vaccine Candidates". Paper presented in The Collaboration for TB Vaccine Discovery (CTVD) 4th Annual Meeting, at the Bill and Melinda Gates Foundation, Seattle, USA., 2018.
  17. Bettencourt, Paulo. "Antigen Discovery and Pre-Clinical Evaluation of Vaccines Against Tuberculosis". Paper presented in VALIDATE 2nd Annual Meeting, York, UK., 2018.
  18. Bettencourt, Paulo. "Factors defining the ability of a liver-stage malaria antigen to reactivate protective CD8+ T cell responses". Paper presented in Malaria Gordon Research Seminar, Les Diablebets, Switzerland., 2017.
  19. Bettencourt, Paulo. "Plasmodium falciparum NF135 Immunopeptidome in Humanized Mice". Paper presented in Malaria Gordon Research Seminar, Les Diablebets, Switzerland., 2017.
  20. Bettencourt, Paulo. "Identifying the factors which make a liver-stage malaria antigen efficacious". Paper presented in British Society for Immunology Congress, Brighton, UK., 2017.
  21. Bettencourt, Paulo. "Identification of Peptides Presented by MHC Class I Molecules in Infected Hepatocytes: Immunogenicity and Efficacy of Novel Malaria Vaccine Candidates". Paper presented in British Society for Immunology - Oxford Immunology Group Annual Meeting, Oxford, UK., 2016.
  22. Bettencourt, Paulo. "Plasmodium falciparum Immunopeptidome in Humanized Mice". Paper presented in EMBO Workshop on Advanced Proteomics, Varna, Italy., 2016.
  23. Bettencourt, Paulo. "Cut or be Cut: Cathepsins and their Inhibitors during mycobacterial infection of Macrophages and Dendritic Cells". Paper presented in 5th iMed.UL Postgraduate Students Meeting, Lisbon, Portugal., 2013.
  24. Bettencourt, Paulo. "Host factors affecting Mycobacterium tuberculosis survival within macrophage". Paper presented in EMBO Conference: Tuberculosis 2012: Biology, pathogenesis, intervention strategies, Paris, France., 2012.
  25. Bettencourt, Paulo. "To Control or to be Controlled During M. tuberculosis Infection? Cathepsins and their Inhibitors within Host Dendritic Cells or Macrophages". Paper presented in EMBO Conference: Tuberculosis 2012: Biology, pathogenesis, intervention strategies, Paris, France., 2012.
  26. Bettencourt, Paulo. "MicroRNA Reduces N-WASP and Controls Phagocytosis of Mycobacterium tuberculosis". Paper presented in Keystone Symposia Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies, Vancouver, Canada., 2011.
  27. Bettencourt, Paulo. "Cathepsins B and S Content in Mycobacterium Containing Compartments in Human Macrophages and Dendritic cells". Paper presented in Current Opinion in Cellular Host-Pathogen Interactions 2010 Conference, Amsterdam, The Netherlands., 2010.
  28. Bettencourt, Paulo. "Interference of Mycobacterium tuberculosis with the endocytic pathways on macrophages and dendritic cells from healthy donors: role of Cathepsins". Paper presented in 3rd International Symposium Celular Delivery of Therapeutic Macromolecules, Cardiff, Wales (United Kingdom)., 2010.
  29. Bettencourt, Paulo. "Role of Mycobacterium tuberculosis outer-membrane porins in bacterial survival within macrophages". Paper presented in 3rd International Symposium Celular Delivery of Therapeutic Macromolecules, Cardiff, Wales (United Kingdom)., 2010.
  30. Bettencourt, Paulo. "MicroRNAs are Involved in Early Steps of Mycobacteria Infection on Macrophages". Paper presented in 2nd EMBO-Institut Pasteur Meeting on Host Genetics Control of Infectious Diseases, Paris, France., 2009.
  31. Bettencourt, Paulo. "Pro- and Anti- Inflammatory Lipids Modulation of Gene Expression on Mycobacteria-Infected Macrophages". Paper presented in Toll2008: Recent Advances in Patter Recognition, Cascais, Portugal., 2008.
  32. Bettencourt, Paulo. "Characterization of Transgenic Mice Ubiquitously Expressing The Recombination Activating Genes-1 and -2 Independently". Paper presented in 30th Annual Meeting of the Portuguese Society for Immunology, Oeiras, Portugal., 2004.
  33. Bettencourt, Paulo. "Comprehensive genome wide RNAi screen for cell division genes in C.elegans". Paper presented in 14th International C. elegans Meeting, University of California, Los Angeles, USA., 2003.
  34. Bettencourt, Paulo. "Purificação de glicolípidos serologicamente activos isolados de Mycobacterium tuberculosis estirpe Canetti". Paper presented in First National Meeting of Mycobacteriologists, Lisboa, Portugal., 1997.
  35. Bettencourt, Paulo. "A multi-antigen ELISA (MA-ELISA) for the serodiagnosis of tuberculosis". Paper presented in 18º Annual Congress of the European Society of Mycobacterilogy, Cordoba, Spain., 1997.
  36. Bettencourt, Paulo. "Extracção e Purificação de Glicolípidos e Fosfolípidos da Parede de Mycobacterium tuberculosis". Paper presented in X National Congress of Biochemistry, Braga, Portugal., 1996.
  37. Bettencourt, Paulo. "Evaluation of protein and glycolipid antigens in the serodiagnosis of tuberculosis". Paper presented in 17º Annual Congress of the European Society of Mycobacterilogy, Paris, France., 1996.
Edited book
  1. Paulo Bettencourt; Ana Mineiro; Paulo Alves; Nuno Rosa; André Correia; Marlene Barros. Center for Interdisciplinary Research in Health (CIIS) National Meeting 2023. BioMed Central Ltd.. 2023.
    10.1186/s12919-023-00269-8
Journal article
  1. Revés J; Fernandez-Clotet A; Ordás I; Buisson A; Bazoge M; Hordonneau C; Ellul P; et al. "Early biological therapy within 12 months of diagnosis leads to higher transmural healing rates in Crohn's disease.". Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2024): http://europepmc.org/abstract/med/39209193.
    10.1016/j.cgh.2024.07.034
  2. Stein Emil Vollset; Hazim S Ababneh; Yohannes Habtegiorgis Abate; Cristiana Abbafati; Rouzbeh Abbasgholizadeh; Mohammadreza Abbasian; Hedayat Abbastabar; et al. "Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00685-8.
    10.1016/s0140-6736(24)00685-8
  3. Michael Brauer; Gregory A Roth; Aleksandr Y Aravkin; Peng Zheng; Kalkidan Hassen Abate; Yohannes Habtegiorgis Abate; Cristiana Abbafati; et al. "Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00933-4.
    10.1016/s0140-6736(24)00933-4
  4. Steinmetz, Jaimie D; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen; Servili, Chiara; Cavallera, Vanessa; et al. "Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet Neurology 23 4 (2024): 344-381. http://dx.doi.org/10.1016/s1474-4422(24)00038-3.
    10.1016/s1474-4422(24)00038-3
  5. Mohsen Naghavi; Kanyin Liane Ong; Amirali Aali; Hazim S Ababneh; Yohannes Habtegiorgis Abate; Cristiana Abbafati; Rouzbeh Abbasgholizadeh; et al. "Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00367-2.
    10.1016/s0140-6736(24)00367-2
  6. Alize J Ferrari; Damian Francesco Santomauro; Amirali Aali; Yohannes Habtegiorgis Abate; Cristiana Abbafati; Hedayat Abbastabar; Samar Abd ElHafeez; et al. "Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00757-8.
    10.1016/s0140-6736(24)00757-8
  7. Jorge R Ledesma; Jianing Ma; Meixin Zhang; Ann V L Basting; Huong Thi Chu; Avina Vongpradith; Amanda Novotney; et al. "Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021". The Lancet Infectious Diseases (2024): http://dx.doi.org/10.1016/s1473-3099(24)00007-0.
    10.1016/s1473-3099(24)00007-0
  8. Austin E Schumacher; Hmwe Hmwe Kyu; Amirali Aali; Cristiana Abbafati; Jaffar Abbas; Rouzbeh Abbasgholizadeh; Madineh Akram Abbasi; et al. "Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00476-8.
    10.1016/s0140-6736(24)00476-8
  9. Natalia V Bhattacharjee; Austin E Schumacher; Amirali Aali; Yohannes Habtegiorgis Abate; Rouzbeh Abbasgholizadeh; Mohammadreza Abbasian; Mohsen Abbasi-Kangevari; et al. "Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021". The Lancet (2024): http://dx.doi.org/10.1016/s0140-6736(24)00550-6.
    10.1016/s0140-6736(24)00550-6
  10. Jingyi Ma; Khatoun Al Moussawi; Hantao Lou; Hok Fung Chan; Yihua Wang; Joseph Chadwick; Chansavath Phetsouphanh; et al. "Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment". Proceedings of the National Academy of Sciences of the United States of America 121 10 (2024): https://ciencia.ucp.pt/en/publications/1fd1518a-2e3f-48bf-89bc-082fcd67b476.
    10.1073/pnas.2309957121
  11. Teresa Nazareth; Gonçalo Seixas; José Lourenço; Paulo J. G. Bettencourt. "Aedes albopictus arrives in Lisbon: an emerging public health threat". Frontiers in Public Health (2023): http://dx.doi.org/10.3389/fpubh.2023.1332334.
    10.3389/fpubh.2023.1332334
  12. Laura Matarazzo; Paulo Bettencourt. "mRNA vaccines". Frontiers in Immunology 14 (2023): https://ciencia.ucp.pt/en/publications/881b5975-d319-475a-9416-090acdd0655c.
    10.3389/fimmu.2023.1172691
  13. Agnès Fernández-Clotet; Joana Revés; Antonhy Buisson; Pierre Ellul; Ainara Elorza; Marta Aduna; Iago Rodríguez-Lago; et al. "35 - LA INTRODUCCIÓN PRECOZ DE LOS FÁRMACOS BIOLÓGICOS EN LOS PRIMEROS 12 MESES DEL DIAGNOSTICO CONSIGUE MAYOR REMISIÓN CLÍNICA, ENDOSCÓPICA Y TRANSMURAL EN LA ENFERMEDAD DE CROHN: ESTUDIO MULTICÉNTRICO EUROPEO CON UN ANÁLISIS PROPENSITY SCORE". Gastroenterología y Hepatología 46 (2023): S67-S67. https://doi.org/10.1016%2Fs0210-5705%2823%2900167-x.
    10.1016/s0210-5705(23)00167-x
  14. J Revés; A Fernandez-Clotet; I Ordás; A Buisson; P Ellul; A Elorza; M Aduna; et al. "P581 Early biological therapy within the first 12 months after diagnosis leads to higher clinical, endoscopic, and transmural remission in Crohn’s disease: European multicentre study with a propensity-score matched analysis". Journal of Crohn's and Colitis 17 Supplement (2023): i709-i709. https://doi.org/10.1093%2Fecco-jcc%2Fjjac190.0711.
    10.1093/ecco-jcc/jjac190.0711
  15. Pires, D.; Bettencourt, P.J.G.. "Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines against Tuberculosis". Journal of Visualized Experiments 2023 197 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85166550147&partnerID=MN8TOARS.
    10.3791/65447
  16. Paulo J. G. Bettencourt; Jorge H. Leitão. "Microbial Antigen Identification and Vaccine Delivery Systems". Vaccines (2022): https://doi.org/10.3390/vaccines10122053.
    10.3390/vaccines10122053
  17. "Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study.". Scientific reports (2022): https://doi.org/10.1038/s41598-022-11748-x.
    10.1038/s41598-022-11748-x
  18. Jamie Medley; Aaron Goff; Paulo J. G. Bettencourt; Madelaine Dare; Liam Cole; Daire Cantillon; Simon J. Waddell. "Dissecting the Mycobacterium bovis BCG Response to Macrophage Infection to Help Prioritize Targets for Anti-Tuberculosis Drug and Vaccine Discovery". Vaccines 10 1 (2022): 113-113. https://doi.org/10.3390/vaccines10010113.
    10.3390/vaccines10010113
  19. "100 years of the Bacillus Calmette-Guérin vaccine". Vaccine (2021): http://dx.doi.org/10.1016/j.vaccine.2021.11.038.
    10.1016/j.vaccine.2021.11.038
  20. Paulo Bettencourt. "6th European Congress of Immunology, 1-4 September 2021, Virtual meeting.". European journal of immunology (2021): https://doi.org/10.1002/eji.202170200.
    10.1002/eji.202170200
  21. Bettencourt PJG. "The 100th anniversary of bacille Calmette-Guérin (BCG) and the latest vaccines against COVID-19.". The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease (2021): http://europepmc.org/abstract/med/34330344.
    10.5588/ijtld.21.0372
  22. Joshua Blight; Katarzyna A Sala; Erwan Atcheson; Holger Kramer; Aadil El-Turabi; Eliana Real; Farah A Dahalan; et al. "Dissection-independent production of Plasmodium sporozoites from whole mosquitoes". Life Science Alliance (2021): https://doi.org/10.26508/lsa.202101094.
    10.26508/lsa.202101094
  23. Paulo Bettencourt. "Current Challenges in the Identification of Pre-Erythrocytic Malaria Vaccine Candidate Antigens". Frontiers in Immunology 11 (2020): https://doi.org/10.3389%2Ffimmu.2020.00190.
    10.3389/fimmu.2020.00190
  24. Bettencourt, Paulo. "Identification of antigens presented by MHC for vaccines against tuberculosis.". NPJ Vaccines (2020): https://europepmc.org/articles/PMC6941960.
    10.1038/s41541-019-0148-y
  25. Tanner, R.; O’Shea, M.K.; White, A.D.; Müller, J.; Harrington-Kandt, R.; Matsumiya, M.; Dennis, M.J.; et al. "Author Correction: The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays (Scientific Reports, (2017), 7, 1, (43478), 10.1038/srep43478)". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063951474&partnerID=MN8TOARS.
    10.1038/s41598-019-41387-8
  26. Bettencourt, P.; Mueller, J.; Nicastri, A.; Madhavan, M.; Fotso, C. B.; Cantillon, D.; Charles, P. D.; et al. "Identification of novel mycobacterial antigens presented by MHC-I and -II by immunopeptidomics for vaccines against tuberculosis". European Journal of Immunology (2019): https://publons.com/publon/27681529/.
  27. Eileen McNeill; Elena Stylianou; Mark J. Crabtree; Rachel Harrington-Kandt; Anna-Lena Kolb; Marina Diotallevi; Ashley B. Hale; et al. "Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin". Nature Communications 9 1 (2018): https://doi.org/10.1038%2Fs41467-018-07714-9.
    10.1038/s41467-018-07714-9
  28. Tanner, R.; O'Shea, M.K.; White, A.D.; Müller, J.; Harrington-Kandt, R.; Matsumiya, M.; Dennis, M.J.; et al. "The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014687396&partnerID=MN8TOARS.
    10.1038/srep43478
  29. Pires D; Bernard EM; Pombo JP; Carmo N; Fialho C; Gutierrez MG; Bettencourt P; Anes E; Bettencourt, Paulo. "Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation.". Frontiers in immunology (2017): http://europepmc.org/abstract/med/29326705.
    10.3389/fimmu.2017.01819
  30. Pires, D.; Marques, J.; Pombo, J.P.; Carmo, N.; Bettencourt, P.; Neyrolles, O.; Lugo-Villarino, G.; et al. "Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84985995945&partnerID=MN8TOARS.
    10.1038/srep32247
  31. Bettencourt, Paulo; Bettencourt, P.; Pires, D.; Anes, E.. "Immunomodulating microRNAs of mycobacterial infections". Tuberculosis 97 (2016): 1-7. https://publons.com/publon/1690937/.
    10.1016/J.TUBE.2015.12.004
  32. Bettencourt, Paulo; Marion, Sabrina; Pires, David; Santos, Leonor F.; Lastrucci, Claire; Carmo, Nuno; Blake, Jonathon; et al. "Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p". Frontiers in Cellular and Infection Microbiology 4 JUN (2013): https://publons.com/publon/8524/.
    10.3389/FCIMB.2013.00019
  33. Pires, D.; Bettencourt, P.; Carmo, N.; Niederweis, M.; Anes, E.. "Role of mycobacterium tuberculosis outermembrane porins in bacterial survival within macrophages". Drug Discovery Today 15 23-24 (2010): 1112-1113. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285235700097&KeyUID=WOS:000285235700097.
    10.1016/J.DRUDIS.2010.09.437
  34. Pires, D.; Bettencourt, P.; Carmo, N.; Bergant, T.; Jordao, L.; Anes, E.. "Interference of mycobacterium tuberculosis with the endocytic pathways on macrophages and dendritic cells from healthy donors: role of cathepsins". Drug Discovery Today 15 23-24 (2010): 1112-1112. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285235700096&KeyUID=WOS:000285235700096.
    10.1016/j.drudis.2010.09.436
  35. C. J. Echeverri; A. A. Hyman; A. Coulson; P. Gönczy; K. Oegema; K. C. Gunsalus; F. Piano; et al. "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans". Nature (London) (2005): https://publons.com/publon/1690940/.
    10.1038/NATURE03353
Thesis / Dissertation
  1. Bettencourt, Paulo Jorge Gonçalves de, 1970-. "Role of pro-and anti-inflammatory lipids in intracellular survival and killing of mycobacteria". PhD, 2012. http://hdl.handle.net/10451/8683.
  2. Bettencourt, Paulo. "Analysis of Transgenic mice Expressing the Recombination Activating Genes 1 and 2". Master, The University of Manchester Faculty of Biology Medicine and Health, 2006.

Other

Other output
  1. Development of a new mRNA vaccine platform for tuberculosis. 2023. Laura Matarazzo; Laura Taina-González; Ricardo Pinheiro; David Pires; María de la Fuente; Paulo Bettencourt. https://ciencia.ucp.pt/en/publications/3010909d-802d-46ee-b015-f630893b7111.
  2. Mass spectrometry-based identification of peptides presented by major histocompatibility complex in macrophages. 2023. Hugo Mateus; Ricardo Pinheiro; Hugo M. Santos; Paulo Bettencourt. https://ciencia.ucp.pt/en/publications/6585fbdd-f324-4ad6-abac-4f1e2246eda5.
  3. Implementation of a pre-Good Laboratory Practice management system for academic research. 2023. Ricardo Pinheiro; Cloé Abreu; Paulo Bettencourt. https://ciencia.ucp.pt/en/publications/586db79a-0862-4ff2-9a8d-6962d6ad04e0.
  4. Identification of peptides presented by MHC. exploring new vaccine antigen candidates against tuberculosis. 2021. Paulo Bettencourt. https://ciencia.ucp.pt/en/publications/dab59ff8-f163-464f-adf8-865b9090eb77.
  5. Dissection-independent production of a protective whole-sporozoite malaria vaccine. 2020. Joshua Blight; Katarzyna A. Sala; Erwan Atcheson; Holger Kramer; Aadil El-Turabi; Eliana Real; Farah A. Dahalan; et al. https://doi.org/10.1101/2020.06.22.164756.
    10.1101/2020.06.22.164756
  6. Identification of novel mycobacterial antigens presented by MHC-I and -II by immunopeptidomics for vaccines against tuberculosis. 2019. Paulo Bettencourt; J. Mueller; A. Nicastri; M. Madhavan; C. B. Fotso; D. Cantillon; P. D. Charles; et al. https://ciencia.ucp.pt/en/publications/062bc677-2a1c-4380-bd97-7623810b10aa.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/11 Immunopeptidomics-based identification of antigens for the development of vaccines against tuberculosis and malaria
NOVA School of Science and Technology, Universidade NOVA de Lisboa (Lisboa, Portugal)
2021/07 Using immunopeptidomics and immunoinformatics to identify novel antigens for subunit vaccines for tuberculosis The Acid Fast Club Summer Meeting 2021
(Southampton, United Kingdom)
2020/10/02 Immunopeptidomics-based identification of antigens presented by MHC-I and MHC-II for vaccines against tuberculosis and malaria
Professor Samuel Behar (Worcester, United States)
2020/02/12 Identification of peptides presented by MHC for vaccines against tuberculosis OxBacNet
University of Oxford (Oxford, United Kingdom)
2020/01/20 Immunopeptidomics-based identification of antigens presented by MHC-I and MHC-II for vaccines against tuberculosis Keystone Symposia Conference on Tuberculosis: Immunity and Immune Evasion
Keystone Symposia (Santa Fe, United States)
2019/09/30 New malaria vaccine candidates: identification and validation of peptides presented by HLA-I in reticulocytes infected with Plasmodium vivax using immunopeptidomics XLIV Annual Congress of the Brazilian Society for Immunology
Brazilian Society for Immunology (Florianópolis, Brazil)
2019/07/04 Identification of novel mycobacterial antigens presented by MHC-I and -II by immunopeptidomics for vaccines against tuberculosis The Acid Fast Club Summer Meeting 2019
Acid Fast Club (St. Andrews, United Kingdom)
2019/05/10 Identification of novel antigens presented by MHC class I using immunopeptidomics for vaccines against malaria Malaria Vaccines for the World
University of Oxford (Oxford, United Kingdom)
2019/02/26 Identification of malaria peptides presented by MHC class I molecules using immunopeptidomics OptiMalVax Annual Meeting
University of Oxford (Vilamoura, Portugal)
2018/04/05 Identification of Peptides Presented by MHC Molecules from Hepatocytes Infected with Plasmodium falciparum using Mass Spectrometry OptiMalVax First Annual Meeting
University of Leiden (Leiden, Netherlands)
2018/02/07 Identification of Mycobacterial Antigens Presented by MHC Molecules from Infected Macrophages using Mass Spectrometry OxBacNet
University of Oxford (Oxford, United Kingdom)
2017/07/01 Plasmodium falciparum NF135 Immunopeptidome in Humanized Mice The Basic Science of Malaria: A Springboard for New Approaches to Control and Elimination
Gordon Seminar (Les Diablerets, Switzerland)
2017/01/06 Identification of Antigens Presented by MHC Molecules from Infected Macrophages using Mass Spectrometry The Acid Fast Club Winter Meeting 2017
Acid Fast Club (London, United Kingdom)
2016/05/02 Evaluation of Plasmodium falciparum SPECT-1 as novel a pre-erythrocytic vaccine candidate Malaria Vaccines for the World Conference
Leiden University Medical Center (Leiden, Netherlands)
2014/07/02 Mycobacterium tuberculosis regulates cathepsin S activity by manipulating the expression of miR-106b 6th iMed.UL Postgraduate Students Meeting
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2014/06/18 Mycobacterium tuberculosis manipulates host cathepsins to increase its survival and lower the expression of antigen presentation molecules Lisbon Workshop on New Strategies to Fight Tuberculosis
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2014/04/28 Designing a New Generation of Tuberculosis Vaccines Based on the Identification of MHC-Associated Peptides OxBacNet
University of Oxford (Oxford, United Kingdom)
2012/04/13 MicroRNA-142-3p Modula a Fagocitose de Micobactérias por Macrófagos através do N-WASP CPM URIA Seminar
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2009/04 Are MicroRNAs Involved in Mycobacterium tuberculosis Infections? URIA Workshop: Mycobacterium Biology and Pathogenesis
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2008/04/10 How Intracellular Pathogens Survive Inside Host Cells? EMBO Practical Course on High-Throughput microRNA Profiling
The European Molecular Biology Laboratory (Heidelberg, Germany)
1997/11 Extracção e Purificação de Glicolípidos da Parede Celular de Mycobacterium tuberculosis Scientific Meeting at the Center for Malaria and Other Tropical Diseases
Universidade Nova de Lisboa
1996/06/05 Structure of the granuloma induced by the intradermal injection of the tubercle bacilli triglycosyl phenolphtiocerol dimycocerosate (PGL-Tb1) in rabbits Annual Congress of the European Society of Mycobacteriology
European Society of Mycobacteriology (Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/12/04 - 2024/05/29 Basic Microbiology Training
Supervisor of Udé Sambú
 Curso Técnico e Superior Profissional de Microbiologia e Biologia Celular (Other)
Instituto Universitário Egas Moniz Escola Superior de Saúde Egas Moniz, Portugal
2024/01/08 - 2024/05/10 Developing a platform for mRNA vacines against tuberculosis
Supervisor of Hansol Min
 Medicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
2023/09/18 - 2024/01/22 Design and development of a mRNA vaccine platform: application for tuberculosis vaccine development
Supervisor of Daniek Sesink
 Medicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
2023/07/10 - 2023/11/24 Design and development of RNA vaccines against tuberculosis
Supervisor of Denzelle-Mae Zimmerman
 Medicine (Master)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Netherlands
2022/09/05 - 2023/11/13 IDENTIFICATION OF PEPTIDES PRESENTED BY MAJOR HISTOCOMPATIBILITY COMPLEX IN MACROPHAGES THROUGH IMMUNOPEPTIDOMICS
Supervisor of Hugo Alexandre Leitão Mateus
 MASTER IN MOLECULAR GENETICS AND BIOMEDICINE (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/06/15 - 2023/06/14 Research and Teaching Laboratory - Research Assistant
Supervisor
Universidade Católica Portuguesa Faculdade de Medicina, Portugal
2018/10/07 - 2022/11/23 PhD student supervision from start to completion. Co-supervisor with Helen McShane and Nicola Ternette on the elution and identification of peptides presented by MHC using Immunopeptidomics (Mass Spectrometry and Bioinformatics).
Co-supervisor of Salem Almurji
University of Oxford The Jenner Institute, United Kingdom
2022/02/21 - 2022/07/06 Host-pathogen interactions
Supervisor of Léa Carré
Université de Technologie de Compiègne, France
2022/03/15 - 2022/04/08 Interações Hospedeiro-Patogénio na Tuberculose: Quantificação de vacinas BCG in vitro
Supervisor of Maria João Sintrão Young
Medicina (Degree)
Universidade do Algarve, Portugal
2018/10/01 - 2019/03/29 PhD student: Training of the PhD candidate in Health Sciences at Oswaldo Cruz Foundation - René Rachou Research Center, on Immunopeptidomics and Antigen Identification in Malaria.
Co-supervisor of Camila Barbosa
University of Oxford The Jenner Institute, United Kingdom
2018/09/17 - 2019/02/08 Undergraduate: Supervision and training of the undergraduate student, Biochemistry Department, University of Oxford.
Supervisor of Katie Plummer
University of Oxford The Jenner Institute, United Kingdom
2018/09/17 - 2019/02/08 Undergraduate: Co-supervision and training of the undergraduate student, Biochemistry Department, University of Oxford.
Co-supervisor of Samih Inceer
University of Oxford The Jenner Institute, United Kingdom
2018/04/03 - 2018/07/06 MSc student: Supervision of the Master student . Thesis title: "Tuberculosis antigen discovery by mass spectrometry".
Supervisor of Meera Madhavan
 MSc in Integrated Immunology (Master)
University of Oxford The Jenner Institute, United Kingdom
2017/01/30 - 2017/07/21 MSc student: Training of the MSc student from Walter Sisulu University, Mthatha, South Africa, from 30th January to 21st July 2017.
Supervisor of Carine Bokop Fotso
University of Oxford The Jenner Institute, United Kingdom
2016/08/08 - 2016/11/23 Undergraduate: Co-supervision of the undergraduate medical student University of Utrecht, The Netherlands.
Co-supervisor of Emma Chisholm Dickinson
 Medicine (Degree)
University of Oxford The Jenner Institute, United Kingdom
2016/07/18 - 2016/09/09 Undergraduate: Training of the undergraduate PharmD student from Federal University of Espirito Santo, Brazil, as a recipient of the prestigious NDM internship award.
Supervisor of Carolina Mastella Botelho
University of Oxford The Jenner Institute, United Kingdom
2015/07/01 - 2015/08/28 Undergraduate: Training of undergraduate Biology student from the University of São Paulo, Brazil, as a recipient of the prestigious NDM internship award.
Supervisor of Juliana de Moraes Rodrigues
University of Oxford The Jenner Institute, United Kingdom
2014/04/28 - 2014/07/15 MSc student: MSc Global Health Science, University of Oxford. Thesis title: "Identification of Plasmodium Peptides as Potential Candidates for New Malaria Vaccines". Awarded a distinction grade.
Supervisor of Quazim Alayo
 MSc Global Health Science (Master)
University of Oxford The Jenner Institute, United Kingdom
2010 - 2011 Graduate: Supervision of the Research Assistant work.
Co-supervisor of Leonor Freire Santos
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020 - Current How to supervise/ to be a transfer and confirmation assessor/ to examine a final viva at Oxford, UK How to supervise/ to be a transfer and confirmation assessor/ to examine a final viva at Oxford
2019 - Current Introduction in principles of PBL and tutoring/teaching skills, Maastricht University, Lisbon, Portugal
Workshop
 Introduction in principles of PBL and tutoring/teaching skills
2018 - Current Preparing for Learning and Teaching at Oxford, University of Oxford, Oxford, UK
Workshop
 Preparing for Learning and Teaching at Oxford
2018 - Current Developing Learning and Teaching, University of Oxford, Oxford, UK
Workshop
 Developing Learning and Teaching
2018 - Current Human Tissue Act Training, University of Oxford, Oxford, UK
Workshop
 Human Tissue Act Training
2018 - Current Problem-Based Learning Course, University of Maastricht, Maastricht, The Netherlands
Workshop
 Problem-Based Learning Course,
2018 - Current NIH Certificate on Protecting Human Research Participants. Certification Number: 2945106
Other
National Institutes of Health, United States
2017 - Current Certificate of DPhil Supervision at Oxford, University of Oxford, Oxford, UK
Other
 Certificate of DPhil Supervision at Oxford
2015 - Current Mass Spectrometry Data Analysis - PEAKS Software Training Workshop, February 2015, Oxford UK
Workshop
 Mass Spectrometry Data Analysis
Bioinformatics Solutions Inc, Canada
2010 - Current IMM Nanocourse: Get the Best From Your Sequences. February 2010, IMM, Lisboa, Portugal
Workshop
 IMM Nanocourse: Get the Best From Your Sequences
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2010 - Current Harvard Medical School - Portugal: RNA Therapeutics. March 2010, IMM, Lisboa, Portugal
Workshop
 Harvard Medical School – Portugal: RNA Therapeutics
2010 - Current Harvard Medical School - Portugal: Quantitative Light Microscopy in Living Cells. April 2010, IMM, Lisboa, Portugal
Workshop
 Harvard Medical School – Portugal: Quantitative Light Microscopy in Living Cells
Harvard Medical School, United States
2009 - Current BioFIG and GABBA Workshop on Gene Expression: 15th April 2009. Faculdade de Ciências, Universidade de Lisboa, Portugal
Workshop
 BioFIG and GABBA Workshop on Gene Expression
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - Current URIA/IMM Symposium. Host-Pathogen Interactions: Strategies for Therapeutic Development. Faculdade de Farmácia, Universidade de Lisboa, Portugal
Symposium
 Host-Pathogen Interactions: Strategies for Therapeutic Development
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - Current IMM Flow Cytometry Workshop. November 2009. IMM, Lisboa, Portugal
Workshop
 Flow Cytometry Workshop
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2008 - Current EMBO Practical Course on High-Throughput microRNA Profiling, April 2008 Heidelberg, Germany
Workshop
European Molecular Biology Laboratory, Germany
2007 - Current Portuguese Government License (Direcção Geral de Veterinária) to carry out regulated procedures in living animals (mice and rats), (group 2), since 4th April 2007
Other
 Portuguese Government License
2006 - Current Laboratory Animal Science Course, with accreditation from FELASA – Federation of European Laboratory Animal Science Associations - Level C (person responsible for directing animal experiments, 80 hours), April 2006, IHMT, Lisboa, Portugal.
Other
 Laboratory Animal Science
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/09/24 - 2020/12/31 Home Office Personal License (PIL) No. IB6B1AA13, to carry out regulated procedures in living animals (mice), modules 1 to 4.
Other
 Home Office Personal License
Home Office, United Kingdom

University of Oxford The Jenner Institute, United Kingdom
2016/07/31 - 2016/08/07 EMBO Workshop on Advanced Proteomics, Varna, Italy
Workshop
 EMBO Workshop on Advanced Proteomics
2016/07/04 - 2016/07/08 MaxQuant Proteomics Data Analysis Course, from 4th to 8th July, 2016, Oxford, UK
Workshop
 MaxQuant Proteomics Data Analysis Course
Max-Planck-Institut für Biochemie, Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/22 The stimulation of the complement system to induce immunogenic cell death as a cancer therapy
(Thesis) Main arguer
 Maria Luís Bretes Gonçalo (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/07/18 Vacinas em desenvolvimento para a tuberculose
(Thesis) Main arguer
 Inês Raposo de Melo Carneiro (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12/13 MiR-21 role in colon cancer predisposition in PSC-IBD patients
(Thesis) Main arguer
 Sarah Tibourtine (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09/22 Developing host-directed-therapies for Mycobacterium tuberculosis and HIV co-infection based on Cystatins manipulation
(Thesis) Main arguer
 Manoj Kumar Mandal (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/12/03 Fatores imunogenéticos para avaliação do risco de infeção por Sars-CoV-2
(Thesis) Main arguer
 Rita Alexandra Lima Marques (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

Society Organization name Role
2023/01/05 - Current Human Proteome Organization - HUPO Member
2022/11/29 - Current Global Burden of Disease (GBD) Collaborator Network Collaborator
2019 - Current European Society of Mycobacteriology Member
2017 - Current Acid Fast Club (membership by invitation only) Member
2017 - Current The Validate Network Associate Member
2017 - Current International Veterinary Vaccine Network Associate Member
2016 - Current British Society for Immunology Member
2016 - Current Microbiology Society Member
2014 - Current PARSUK - Portuguese Association of Researchers and Students in the United Kingdom Member
2004 - Current Portuguese Society of Immunology Member
2004 - Current Associação Viver a Ciência Member
1996 - Current Portuguese Biochemical Society Member

Consulting

Activity description Institution / Organization
2016 - 2020 Planning, submission and execution of the application of the Portuguese Catholic University Medical degree to the Portuguese Governmental authorities (A3ES). Co-founder of the Medical degree and the Faculty Medicine of the Catholic University of Portugal. Universidade Católica Portuguesa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/05/12 - Current Introduction to the Research Laboratory in Immunology Block coordinator of the Integrated Masters in Medicine, at the Faculty of Medicine, UCP. Medicina (Mestrado integrado) Universidade Católica Portuguesa Faculdade de Medicina, Portugal
2021/01/01 - 2022/07/07 Block coordinator of the Integrated Masters in Medicine, at the Faculty of Medicine, UCP. Block Digestion & Defence I Medicina (Mestrado integrado) Universidade Católica Portuguesa Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/10/18 The Lancet Microbe Interview. Provided an independent comment about the study from William Heath´s group: Ganley, M., Holz, L.E., Minnell, J.J. et al. mRNA vaccine against malaria tailored for liver-resident memory T cells. Nat Immunol 24, 1487-1498 (2023). https://doi.org/10.1038/s41590-023-01562-6 The Lancet Microbe
2020/04/12 "A covid-19 mata menos nos países com pessoas vacinadas com a BCG?". I gave an interview to the major Portuguese newspaper about the use of BCG as potential vaccine against COVID-19. Público
2020/01/09 "Tuberculose: há novos alvos para melhorar a velha vacina que temos". I gave an interview to the major Portuguese newspaper Público about my BCG work published in 2020. Público

Interview (tv / radio show)

Program Topic
2021/02/12 - Current Guest for an interview in the major Portuguese TV channel RTP about COVID-19 vaccines, program Janela Global, on 12th February 2021.
2020/04/29 - Current Special Guest for a 50 minutes interview in the major Portuguese TV channel RTP about vaccines, program Grande Entrevista, on 29th April 2020. A ciência e a indústria farmacêutica numa corrida contra o coronavírus

Journal scientific committee

Journal title (ISSN) Publisher
2024/03/19 - Current Journal of Medical Microbiology (0022-2615) Microbiology Society
2023/08/29 - Current PLOS Global Public Health (2767-3375) Public Library of Science (PLOS)
2023 - Current Microbes and Infection Institut Pasteur
2021 - Current Access microbiology (2516-8290) Microbiology Society
2020 - Current Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (1876-4320) Elsevier
2020 - Current Emerging microbes & infections (2222-1751) Springer Nature
2020 - Current BMC immunology (1471-2172) London: BioMed Central
2020 - Current European journal of inflammation (2058-7392) SAGE Publishing
2020 - Current Frontiers in public health (2296-2565) Frontiers Media S.A.
2020 - Current npj vaccines (2059-0105) Springer Nature
2020 - Current Pathogens (2076-0817) MDPI
2020 - Current Vaccines (2076-393X) MDPI
2020 - Current Vaccine (0264-410X) Elsevier
2019/09/27 - Current Frontiers in Immunology (1664-3224) Frontiers Media S.A.
2019 - Current Immunology letters (1879-0542) Elsevier
2017 - Current Journal of immunology research (2314-7156) Hindawi
2015 - Current Parasite immunology (0141-9838) John Wiley & Sons, Inc.
2015 - Current Scientific reports (2045-2322) Springer Nature

Other jury / evaluation

Activity description Institution / Organization
2023/11/01 - Current Grant Reviewer for the Botnar Foundation, Basel, Switzerland.
2020 - Current Grant Reviewer for The Netherlands Organization for Health Research and Development (ZonMw)
2019 - Current Jury of the Prize Best Article. Fundação Oswaldo Cruz Instituto René Rachou, Brazil
2018 - Current Jury of the Prize Best Article. Fundação Oswaldo Cruz Instituto René Rachou, Brazil
2018 - Current Grant Reviewer of Newton Advanced Fellowship applications for the Academy of Medical Sciences in partnership with the Royal Society and the British Academy , United Kingdom. The Royal Society, United Kingdom
Distinctions

Award

2022 Junior Investigator Poster Award, The Collaboration for TB Vaccine Discovery, Bill & Melinda Gates Foundation
Bill & Melinda Gates Foundation, United States
2018 VALIDATE Network Travel Award, United Kingdom
VALIDATE Network, United Kingdom
2018 Junior Investigator Poster Award, The Collaboration for TB Vaccine Discovery, Bill & Melinda Gates Foundation
Bill & Melinda Gates Foundation, United States
2008 Student/post-doc registration to Toll2008 meeting, Cascais, Portugal
University of Massachusetts Medical School, United States

Title

2024 Fellow of The Royal Society of Biology
The Royal Society of Biology, United Kingdom

Other distinction

2015 Associate Member, Magdalen College, Oxford, United Kingdom
University of Oxford Magdalen College, United Kingdom
2013 Post-Doctoral Scientist Fellowship, Jenner Institute, University of Oxford, United Kingdom
University of Oxford The Jenner Institute, United Kingdom
2006 PhD Fellowship, FCT, Portugal
Fundação para a Ciência e a Tecnologia, Portugal
1995 Research Technician Fellowship, FCT, Portugal
Fundação para a Ciência e a Tecnologia, Portugal