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João Xavier Santos. Concluiu o(a) Mestrado em Biologia Molecular e Genética em 2013 pelo(a) Universidade de Lisboa Faculdade de Ciências e Licenciatura em Biologia em 2011 pelo(a) Universidade de Évora Escola de Ciências e Tecnologia. Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Genética Humana.
Identification

Personal identification

Full name
João Pedro Xavier dos Santos

Citation names

  • Xavier Santos, João

Author identifiers

Ciência ID
4013-C8E3-FDF3
ORCID iD
0000-0003-2797-5513

Addresses

  • Instituto de Biossistemas e Ciências Integrativas (BioISI) - Faculdade de Ciências da Universidade de Lisboa (FCUL). Rua Ernesto de Vasconcelos, 1749-016, Lisboa, Lisboa, Portugal (Professional)
  • Instituto Nacional de Saúde Doutor Ricardo Jorge , 1649-016, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2016/03/01 - 2023/01/26
Concluded
 Biologia (Doutoramento)
Major in Biologia de Sistemas
Universidade de Lisboa Faculdade de Ciências, Portugal
"Gene-environment interactions in Autism Spectrum Disorder" (THESIS/DISSERTATION)
2011/09/11 - 2013/11/13
Concluded
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"The Role of ArlGTPases in the infection of macrophages by Salmonella" (THESIS/DISSERTATION)
 16
2008/09/06 - 2011/07/16
Concluded
 Biologia (Licenciatura)
Universidade de Évora Escola de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2014/01/01 - 2015/07/01 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Other Careers

Category
Host institution 		Employer
2019/02/01 - Current Técnico Superior (Técnico Superior) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Contract

Designation Funders
2019/10 - 2022/10 Gene-environment interactions in Autism Spectrum Disorder (GEnvIA)
PTDC/MED-OUT/28937/2017
PhD Student Fellow
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/01 - 2018/01 Autism Spectrum Disorders in the European Union (ASDEU)
SANCO/2014/C2/035
PhD Student Fellow
Concluded

Other

Designation Funders
2023/10/01 - Current Genomic Data Infrastructure (GDI)
GDI-ID-101081813
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 European Commission
2023/09/01 - Current A European consortium to determine how complex, real-world environments influence brain development
OC-2022-1-25773
Researcher
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Xavier Santos, João; Celia Rasga; Astrid M Vicente. "Exposure to Xenobiotics and Gene-Environment Interactions in Autism Spectrum Disorder: A Systematic Review". In Autism - Heterogeneity, Etiological Core and Outcome, edited by IntechOpen. 2021.
    Published • http://dx.doi.org/10.5772/intechopen.95758
  2. Joana Vilela; Muhammad Asif; Ana Rita Marques; João Xavier Santos; Célia Rasga; Astrid Vicente; Hugo Martiniano. "Biomedical Knowledge Graph Embeddings for Personalized Medicine". 2021.
    10.1007/978-3-030-86230-5_46
  3. João Xavier Santos; Célia Rasga; Astrid Moura Vicente. "Exposure to Xenobiotics and Gene-Environment Interactions in Autism Spectrum Disorder: A Systematic Review". {IntechOpen, 2021.
    10.5772/intechopen.95758
Conference poster
  1. Xavier Santos, João; Hugo Martiniano; Ana Rita Marques; Celia Rasga; Joana Vilela; Astrid M Vicente. "Exploring mechanisms of gene-environment interactions contributing to the onset of idiopathic Autism Spectrum Disorder". Paper presented in European Human Genetics Virtual Conference 2020, 2020.
  2. Xavier Santos, João; Ana Rita Marques; Hugo Martiniano; Joana Vilela; Celia Rasga; Guiomar Oliveira; Astrid M Vicente. "Rare variants targeting genes that encode for cytochrome P450 enzymes in Autism Spectrum Disorder". Paper presented in 52nd European Society of Human Genetics Conference, 2019.
  3. Xavier Santos, João; Ana Rita Marques; Celia Rasga; Muhammad Asif; Joana Vilela; Hugo Martiniano; Guiomar Oliveira; Ana Nunes; Astrid M Vicente. "A role for gene-environment interactions in Autism Spectrum Disorder is suggested by an excess of potentially pathogenic variants in genes regulating exposure to toxicants". Paper presented in 51st European Society of Human Genetics Conference, 2018.
  4. Xavier Santos, João; Celia Rasga; Ana Rita Marques; Astrid M Vicente. "CNVs targeting genes that regulate exposure to toxicants in Autism Spectrum Disorder (ASD) - a role for gene-environment interactions". Paper presented in 2017 International Meeting for Autism Research, 2017.
Journal article
  1. Joana Vilela; Hugo Martiniano; Ana Rita Marques; João Xavier Santos; Muhammad Asif; Célia Rasga; Guiomar Oliveira; Astrid Moura Vicente. "Identification of Neurotransmission and Synaptic Biological Processes Disrupted in Autism Spectrum Disorder Using Interaction Networks and Community Detection Analysis". Biomedicines (2023): https://doi.org/10.3390/biomedicines11112971.
    10.3390/biomedicines11112971
  2. Célia Rasga; João Xavier Santos; Cátia Café; Alexandra Oliveira; Frederico Duque; Manuel Posada; Ana Nunes; Guiomar Oliveira; Astrid Moura Vicente. "Prevalence of Autism Spectrum Disorder in the Centro region of Portugal: a population based study of school age children within the ASDEU project". Frontiers in Psychiatry 14 (2023): http://dx.doi.org/10.3389/fpsyt.2023.1148184.
    10.3389/fpsyt.2023.1148184
  3. João Xavier Santos; Pedro Sampaio; Célia Rasga; Hugo Martiniano; Clarissa Faria; Cátia Café; Alexandra Oliveira; et al. "Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder". Environmental Research (2023): https://doi.org/10.1016/j.envres.2023.115795.
    10.1016/j.envres.2023.115795
  4. Joana Vilela; Muhammad Asif; Ana Rita Marques; João Xavier Santos; Célia Rasga; Astrid Vicente; HFMC Martiniano. "Biomedical knowledge graph embeddings for personalized medicine: Predicting disease-gene associations". Expert Systems (2022): http://dx.doi.org/10.1111/exsy.13181.
    10.1111/exsy.13181
  5. Joana Vilela; Hugo Martiniano; Ana Rita Marques; João Xavier Santos; Célia Rasga; Guiomar Oliveira; Astrid Moura Vicente. "Disease similarity network analysis of Autism Spectrum Disorder and comorbid brain disorders". Frontiers in Molecular Neuroscience 15 (2022): http://dx.doi.org/10.3389/fnmol.2022.932305.
    10.3389/fnmol.2022.932305
  6. João Xavier Santos; Célia Rasga; Ana Rita Marques; Hugo Martiniano; Muhammad Asif; Joana Vilela; Guiomar Oliveira; et al. "A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics". Frontiers in Neuroscience 16 (2022): http://dx.doi.org/10.3389/fnins.2022.862315.
    10.3389/fnins.2022.862315
  7. Ana Rita Marques; João Xavier Santos; Hugo Martiniano; Joana Vilela; Célia Rasga; Luísa Romão; Astrid Moura Vicente. "Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder". Biomedicines 10 3 (2022): 665-665. https://doi.org/10.3390/biomedicines10030665.
    10.3390/biomedicines10030665
  8. Asif, Muhammad; Martiniano, Hugo F. M. C.; Marques, Ana Rita; Xavier Santos, João; Vilela, Joana; Rasga, Celia; Oliveira, Guiomar; Couto, Francisco M.; Vicente, Astrid M.. "Identification of biological mechanisms underlying a multidimensional ASD phenotype using machine learning". Translational Psychiatry 10 1 (2020): http://dx.doi.org/10.1038/s41398-020-0721-1.
    10.1038/s41398-020-0721-1
  9. Xavier Santos, João; Celia Rasga; Ana Rita Marques; Hugo Martiniano; Muhammad Asif; Joana Vilela; Guiomar Oliveira; Astrid M Vicente. "A role for gene-environment interactions in Autism Spectrum Disorder is suggested by variants in genes regulating exposure to environmental factors". bioRxiv (2019):
    Open access • Accepted • 10.1101/520544
Newsletter article
  1. Celia Rasga; Xavier Santos, João; Cátia Café; Alexandra Oliveira; Frederico Duque; Ana Nunes; Guiomar Oliveira; Astrid M Vicente. "Prevalência da perturbação do espectro do autismo na região Centro de Portugal: um estudo no âmbito do projeto ASDEU", Boletim Epidemiológico Observações, 2020, http://www.insa.min-saude.pt/category/informacao-e-cultura-cientifica/publicacoes/boletim-epidemiologico-observacoes-numero-27/.
  2. Xavier Santos, João; Célia Rasga; Ana Rita Marques; Muhammad Asif; Astrid M Vicente. "Interações gene-ambiente na perturbação do espetro do autismo", Boletim Epidemiológico Observações, 2017, http://www.insa.min-saude.pt/category/informacao-e-cultura-cientifica/publicacoes/boletim-epidemiologico-observacoes-suplemento-9/.
Thesis / Dissertation
  1. Xavier Santos, João. "The Role of Arl GTPases in the infection of macrophages by Salmonella". Master, Universidade de Lisboa Faculdade de Ciências, 2013. http://hdl.handle.net/10451/9641.
Distinctions

Award

2020 Conference Fellowship for European Countries

Other distinction

2017 Participant of the 11th class of Roche Continents Programme
F Hoffmann-La Roche AG, Switzerland