Personal identification

Full name

Ana Rita Agra de Almeida Quadros

Citation names

• Quadros, Ana
• Ana Rita Agra de Almeida Quadros
• Ana R. A. A. Quadros
• Ana Rita A. A. Quadros

Author identifiers

Ciência ID

3F1E-491E-23F5

ORCID iD

0000-0002-6909-2420

Knowledge fields

• Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

	Degree	Classification
2021 Concluded	Neuroscience (Doctor of Philosophy) Vrije Universiteit Amsterdam, Netherlands "Fbxo41 Regulates Hippocampal Development." (THESIS/DISSERTATION)
2014 Concluded	Master in Neuroscience (Master) Major in Multi-degree european master in Neuroscience Neurasmus, France "Effect of omega-3 in microglia and synaptic pruning after prenatal infection." (THESIS/DISSERTATION)
2014 Concluded	Neuroscience (Master) Vrije Universiteit Amsterdam, Netherlands
2014 Concluded	Neuroscience (Master) Université de Bordeaux, France
2014 Concluded	Clinical Neurosciences (Master) Charité - Universitätsmedizin Berlin, Germany
2012 Concluded	Bioquímica (Licenciatura) Universidade de Coimbra, Portugal "Effects of Exposure to Antiepileptic Drugs During Gestation and Nursing Periods in the Cognitive Capacities of CD1-mice" (THESIS/DISSERTATION)	16 (10th percentile)

Science

	Category Host institution	Employer
2020 - 2024	Postdoc (Research)	Massachusetts General Hospital & Harvard Medical School, United States
	Massachusetts General Hospital & Harvard Medical School, United States

Grant

	Designation	Funders
2022 - 2024	TDP-43-dependent truncation of Stathmin-2 mRNA as a novel target in Alzheimer’s disease A2022002F Researcher Massachusetts General Hospital & Harvard Medical School, United States	BrightFocus Foundation Concluded
2009 - 2009	Preparing organic compounds to be studied as novel drug vehicles Bolsa de Integracao a Investigacao Integration into Research Grant Fellow

Contract

	Designation	Funders
2012 - 2016	Fbxo41 is not required for presynaptic vesicle release CognitionNet FP7-ITN- 607508 PhD Student Fellow Vrije Universiteit Amsterdam, Netherlands

Publications

Journal article

Ana Rita Agra Almeida Quadros; Zhaozhi Li; Xue Wang; I. Sandra Ndayambaje; Sandeep Aryal; Nandini Ramesh; Matthew Nolan; et al. "Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease". Acta Neuropathologica (2024): http://dx.doi.org/10.1007/s00401-023-02655-0. 10.1007/s00401-023-02655-0 López-Erauskin, J.; Bravo-Hernandez, M.; Presa, M.; Baughn, M.W.; Melamed, Z.; Beccari, M.S.; Agra de Almeida Quadros, A.R.; et al. "Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation". Nature Neuroscience 27 1 (2024): 34-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-85177562718&partnerID=MN8TOARS. 10.1038/s41593-023-01496-0 Held A; Adler M; Marques C; Reyes CJ; Kavuturu AS; Quadros ARAA; Ndayambaje IS; et al. "iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons.". Cell reports (2023): https://doi.org/10.1016/j.celrep.2023.113046. 10.1016/j.celrep.2023.113046 Michael W. Baughn; Ze'ev Melamed; Jone Lopez Erauskin; Melinda Beccari; Karen Ling; Aamir Zuberi; Maximiliano Presa; et al. "Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies.". Science (New York, N.Y.) (2023): https://doi.org/10.1126/science.abq5622. 10.1126/science.abq5622 "Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation". iScience 25 4 (2022): 104069-104069. http://dx.doi.org/10.1016/j.isci.2022.104069. 10.1016/j.isci.2022.104069 "Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime". Neuropsychopharmacology (2020): http://dx.doi.org/10.1038/s41386-020-00793-7. 10.1038/s41386-020-00793-7 King, C.R.; A. A. Quadros, A.R.; Chazeau, A.; Saarloos, I.; van der Graaf, A.J.; Verhage, M.; Toonen, R.F.. "Fbxo41 Promotes Disassembly of Neuronal Primary Cilia". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066792399&partnerID=MN8TOARS. 10.1038/s41598-019-44589-2

Thesis / Dissertation

"The Role of FBXO41 in Neuronal Function and Hippocampal Development". 2021. https://research.vu.nl/en/publications/187cff52-a0bc-429e-9d26-748760bf74bf.

Award

2022	Postdoctoral Fellowship from BrightFocus Foundation (A2022002F; $200.000) BrightFocus Foundation, United States
2022	Selected Speaker, and winner of best lightening talk, Neurology Retreat, MGH Massachusetts General Hospital, United States
2014	Marie Curie Network Fellowship (CognitionNet FP7-ITN- 607508) European Union, Belgium
2013	Bourses d'excellence Eole, Réseau franco-néerlandais (Franco-Dutch Network, €500) Frans Nederlandse Academie, Netherlands
2012	Neurasmus Scholarship , European Union (€12.000) European Union, Belgium
2009	Scholarship for Integration in Investigation Fundação para a Ciência e a Tecnologia, Portugal

Other distinction

2024	Chair and selected speaker at AD/PD Conference (Lisbon) Kenes International Organizers of Congresses SA, Switzerland