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Francisca Lopes received her MSc degree in Pharmaceutical Sciences and holds a PhD in Medicinal Chemistry from the University of Lisbon. She joined the Faculty of Pharmacy at the University of Lisbon (FFUL) as an Assistant Professor in 2001, and was promoted to Associate Professor of Medcinal Chemistry in 2012. Francisca received the Habilitation in Pharmaceutical Sciences from FFUL in 2016. Francisca Lopes has successfully established an international research program on medicinal chemistry for tuberculosis and malaria, involving the collaboration with the University of California at S. Francisco (UCSF) and University of Cape Town (UCT). This program received the support from the Medicines for Malaria Venture (MMV). Her research program in tuberculosis and malaria drug discovery. She has has successfully (co-)mentored >20 MSc/PhD students and postdocs during her career. Francisca Lopes has established herself as an authority in the development of innovative chemical entities endowed with multi-targeting mechanisms of action applied to malaria and tuberculosis, regularly publishing reviews/research in highly recognised journals. She has published > 40 manuscripts, inlcuding in journals such as J Med Chem and ACS Med Chem Lett, and is inventor in 1 patent.
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Identification

Personal identification

Full name
Francisca Lopes

Citation names

  • Lopes, Francisca

Author identifiers

Ciência ID
3911-17F9-540E
ORCID iD
0000-0002-5350-147X

Telephones

Telephone
  • 217946400 (Personal)

Addresses

  • Faculdade de Farmácia da Universidade de Lisboa. Av Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree Classification
2016/06
Concluded
 Medicinal Chemistry (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2000
Concluded
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Potenciais Pró-fármacos de sulfonamidas. Reactividade química e enzimática" (THESIS/DISSERTATION)
 Muito Bom com Distinção e louvor
1986
Concluded
 Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa, Portugal
"Potenciais Pró-fármacos de Sulfonamidas : Reactividade Química e Enzimática" (THESIS/DISSERTATION)
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2012/07 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2000/04 - 2012/07 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1990/10 - 2000/04 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
1986/04/30 - 1990/10/17 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2022/10/27 - Current Iron-triggered technologies as a novel targeted therapy for cancer
LCF/TR/CI22/52660003
Researcher
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação 'la Caixa'
Ongoing
2023 - 2026 Ferrous Iron-Activable Drug Conjugates: Targeting Iron Metabolism in the Era of Precision Oncology
2022.07857.PTDC
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Researcher
Universidade Nova de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MED-FAR/30266/2017
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
PTDC/SAU-FAR/118459/2010
grant.Provided by PTCRIS: 118459
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia

Stichting Weten
Concluded
2010/04 - 2013/09 New drugs for treating and eradicating malaria
grant.Provided by PTCRIS: 110357
HMSP-CT/SAU-ICT/0068/2009
Researcher
Instituto de Medicina Molecular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Stichting Weten

Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/06 Targeting the mitochondrial electron transport chain of malaria parasites: computer-assisted design and synthesis of bc1 complex inhibitors as antimalarial agents
grant.Provided by PTCRIS: 98734
PTDC/SAU-FCF/098734/2008
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Stichting Weten

Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010 Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal activity
PTDC/QUI/65142/2006
Researcher
Universidade do Porto Centro de Investigação em Química, Portugal
Concluded
2002 - 2005 A new approach to antimalarial therapy. Novel chemical delivery systems for primaquine and amodiaquine
POCTI/FCB/39218/2001
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Lopes, Francisca. "Knorr Pyrazole Synthesis of Edaravone". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 366-369. RSC, 2016.
    Published
  2. Lopes, Francisca. "Preparation of Nitrostilbenes by the Wittig reaction". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 623-626. RSC, 2016.
    Published
  3. Lopes, Francisca. "Synthesis of Hippuric acid: an Example of Amide Bond Formation". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 147-150. RSC, 2016.
    Published
  4. Lopes, Francisca. "Stereoselective Epoxidation of Cholesterol by m-Chloroperoxybenzoic Acid.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 754-757. RSC, 2016.
    Published
  5. Lopes, Francisca. "Preparation of a sulfathiazole prodrug via N-acylation with succinic anhydride". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC). RSC, 2016.
    Published
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". 2015.
    10.1515/9783110468755-002
  7. Raquel, Ana; Lopes, Francisca; Moreira, Rui; Coelho, Ana; Rosrio, Maria. "Contribution of Mass Spectrometry to the Study of Antimalarial Agents". In Tandem Mass Spectrometry - Molecular Characterization. InTech, 2013.
    Published • 10.5772/56225
  8. Lopes, Francisca. "Azetidin-2-ones and Related Systems as Enzymes Inhibitors: Synthesis and Reactivity". In Heterocyclic Targets in Advanced Organic Synthesis. Research Signpost, 2011.
    Published
  9. Lopes, Francisca. "Liposomes as Carrier Systems for Proteins: Factors Affecting Protein Encapsulation". In Liposomes in the Therapy of Infectious Diseases and Cancer. Alan R. Liss Inc., 1989.
    Published
Journal article
  1. Leite, Debora I.; Campaniço, Andre; Costa, Pedro A. G.; Correa, Isadora A.; da Costa, Luciana J.; Bastos, Monica M.; Moreira, Rui; et al. "New azaaurone derivatives as potential multitarget agents in HIV-TB coinfection". Archiv der Pharmazie 357 2 (2023): http://dx.doi.org/10.1002/ardp.202300560.
    10.1002/ardp.202300560
  2. Campaniço, André; Harjivan, Shrika G.; Freitas, Elisabete; Serafini, Marco; Gaspar, M. Manuela; Capela, Rita; Gomes, Pedro; et al. "Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability". ChemMedChem 18 24 (2023): http://dx.doi.org/10.1002/cmdc.202300410.
    10.1002/cmdc.202300410
  3. Rita Capela; Rita Félix; Marta Clariano; Diogo Nunes; Maria de Jesus Perry; Francisca Lopes. "Target Identification in Anti-Tuberculosis Drug Discovery". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241310482.
    10.3390/ijms241310482
  4. Ana Georgina Gomes-Alves; Margarida Duarte; Tânia Cruz; Helena Castro; Francisca Lopes; Rui Moreira; Ana S. Ressurreição; Ana M. Tomás. "Biological Evaluation and Mechanistic Studies of Quinolin-(1 H )-Imines as a New Chemotype against Leishmaniasis". Antimicrobial Agents and Chemotherapy (2021): https://doi.org/10.1128/AAC.01513-20.
    10.1128/AAC.01513-20
  5. André Campaniço; Shrika G. Harjivan; Digby Warner; R Moreira; Francisca Lopes. "Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/22/8854.
    10.3390/ijms21228854
  6. Nunes, Andreia; Marto, Joana; Gonçalves, Lídia Maria; Simões, Sandra; Félix, Rita; Ascenso, Andreia; Lopes, Francisca; Ribeiro, Helena Margarida. "Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management". Pharmaceutics 12 4 (2020): 358. http://dx.doi.org/10.3390/pharmaceutics12040358.
    Accepted • 10.3390/pharmaceutics12040358
  7. Lopes, Francisca. "An Overview of Drug Resistance in Protozoal Diseases". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20225748.
    10.3390/ijms20225748
  8. Lopes, Francisca. "Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB". ChemMedChem (2019): http://dx.doi.org/10.1002/cmdc.201900289.
    10.1002/cmdc.201900289
  9. Capela, R.; Magalhães, J.; Miranda, D.; Machado, M.; Sanches-Vaz, M.; Albuquerque, I.S.; Sharma, M.; et al. "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability". European Journal of Medicinal Chemistry 149 (2018): 69-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042651839&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.02.048
  10. Campaniço, A.; Moreira, R.; Lopes, F.. "Drug discovery in tuberculosis. New drug targets and antimycobacterial agents". European Journal of Medicinal Chemistry 150 (2018): 525-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043527030&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.03.020
  11. Oliveira, R.; Miranda, D.; Magalhães, J.; Capela, R.; Perry, M.J.; O'Neill, P.M.; Moreira, R.; Lopes, F.. "From hybrid compounds to targeted drug delivery in antimalarial therapy". Bioorganic and Medicinal Chemistry 23 16 (2015): 5120-5130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938951204&partnerID=MN8TOARS.
    10.1016/j.bmc.2015.04.017
  12. Amorim Madeira, P.J.; Sitoe, A.R.F.; Gonçalves, D.; Rodrigues, T.; Guedes, R.C.; Lopes, F.; Moreira, R.; Bronze, M.R.. "Antiplasmodial drugs in the gas phase: A CID and DFT study of Quinolon-4(1H)-imine derivatives". Journal of the American Society for Mass Spectrometry 25 9 (2014): 1650-1661. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905716107&partnerID=MN8TOARS.
    10.1007/s13361-014-0940-x
  13. Miranda, D.; Capela, R.; Albuquerque, I.S.; Meireles, P.; Paiva, I.; Nogueira, F.; Amewu, R.; et al. "Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities". ACS Medicinal Chemistry Letters 5 2 (2014): 108-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894075620&partnerID=MN8TOARS.
    10.1021/ml4002985
  14. Oliveira, R.; Guedes, R.C.; Meireles, P.; Albuquerque, I.S.; Gonçalves, L.M.; Pires, E.; Bronze, M.R.; et al. "Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials". Journal of Medicinal Chemistry 57 11 (2014): 4916-4923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902449185&partnerID=MN8TOARS.
    10.1021/jm5004528
  15. Carrasco, M.P.; Gut, J.; Rodrigues, T.; Ribeiro, M.H.L.; Lopes, F.; Rosenthal, P.J.; Moreira, R.; Dos Santos, D.J.V.A.. "Exploring the molecular basis of Qobc1complex inhibitors activity to find novel antimalarials hits". Molecular Informatics 32 7 (2013): 659-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880276957&partnerID=MN8TOARS.
    10.1002/minf.201300024
  16. Rodrigues, T.; Da Cruz, F.P.; Lafuente-Monasterio, M.J.; Gonçalves, D.; Ressurreição, A.S.; Sitoe, A.R.; Bronze, M.R.; et al. "Quinolin-4(1 H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria". Journal of Medicinal Chemistry 56 11 (2013): 4811-4815. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879038195&partnerID=MN8TOARS.
    10.1021/jm400246e
  17. Ressurreição, A.S.; Gonçalves, D.; Sitoe, A.R.; Albuquerque, I.S.; Gut, J.; Góis, A.; Gonçalves, L.M.; et al. "Structural optimization of quinolon-4(1 H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability". Journal of Medicinal Chemistry 56 19 (2013): 7679-7690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885635225&partnerID=MN8TOARS.
    10.1021/jm4011466
  18. Oliveira, R.; Newton, A.S.; Guedes, R.C.; Miranda, D.; Amewu, R.K.; Srivastava, A.; Gut, J.; et al. "An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites". ChemMedChem 8 9 (2013): 1528-1536. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883052282&partnerID=MN8TOARS.
    10.1002/cmdc.201300202
  19. Rodrigues, T.; Ressurreição, A.S.; Da Cruz, F.P.; Albuquerque, I.S.; Gut, J.; Carrasco, M.P.; Gonçalves, D.; et al. "Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds". European Journal of Medicinal Chemistry 69 (2013): 872-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885342864&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.008
  20. Rodrigues, T.; Prudêncio, M.; Moreira, R.; Mota, M.M.; Lopes, F.. "Targeting the liver stage of malaria parasites: A yet unmet goal". Journal of Medicinal Chemistry 55 3 (2012): 995-1012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856909677&partnerID=MN8TOARS.
    10.1021/jm201095h
  21. Rodrigues, T.; Lopes, F.; Moreira, R.. "Microwave-assisted wittig reaction of semistabilized nitro-substituted benzyltriphenyl-phosphorous ylides with aldehydes in phase-transfer conditions". Synthetic Communications 42 5 (2012): 747-755. http://www.scopus.com/inward/record.url?eid=2-s2.0-80755130326&partnerID=MN8TOARS.
    10.1080/00397911.2010.530378
  22. Rodrigues, T.; Dos Santos, D.J.V.A.; Moreira, R.; Lopes, F.; Guedes, R.C.. "A quantum mechanical study of novel potential inhibitors of cytochrome bc1 as antimalarial compounds". International Journal of Quantum Chemistry 111 6 (2011): 1196-1207. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952142347&partnerID=MN8TOARS.
    10.1002/qua.22741
  23. Rodrigues, T.; Moreira, R.; Lopes, F.. "New hope in the fight against malaria?". Future Medicinal Chemistry 3 1 (2011): 1-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650654244&partnerID=MN8TOARS.
    10.4155/fmc.10.274
  24. Rodrigues, T.; Moreira, R.; Gut, J.; Rosenthal, P.J.; O'Neill, P.M.; Biagini, G.A.; Lopes, F.; Dos Santos, D.J.V.A.; Guedes, R.C.. "Identification of new antimalarial leads by use of virtual screening against cytochrome bc1". Bioorganic and Medicinal Chemistry 19 21 (2011): 6302-6308. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054911881&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.09.004
  25. Capela, R.; Cabal, G.G.; Rosenthal, P.J.; Gut, J.; Mota, M.M.; Moreira, R.; Lopes, F.; Prudêncio, M.. "Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy". Antimicrobial Agents and Chemotherapy 55 10 (2011): 4698-4706. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052865308&partnerID=MN8TOARS.
    10.1128/AAC.05133-11
  26. Rodrigues, T.; Lopes, F.; Moreira, R.. "Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status". Current Medicinal Chemistry 17 10 (2010): 929-956. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950637685&partnerID=MN8TOARS.
    10.2174/092986710790820660
  27. Capela, R.; Oliveira, R.; Gonçalves, L.M.; Domingos, A.; Gut, J.; Rosenthal, P.J.; Lopes, F.; Moreira, R.. "Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition". Bioorganic and Medicinal Chemistry Letters 19 12 (2009): 3229-3232. http://www.scopus.com/inward/record.url?eid=2-s2.0-65749094248&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.04.100
  28. Rodrigues, T.; Guedes, R.C.; dos Santos, D.J.V.A.; Carrasco, M.; Gut, J.; Rosenthal, P.J.; Moreira, R.; Lopes, F.. "Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials". Bioorganic and Medicinal Chemistry Letters 19 13 (2009): 3476-3480. http://www.scopus.com/inward/record.url?eid=2-s2.0-66349136182&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.05.017
  29. Rodrigues, T.; Moreira, R.; Dacunha-Marinho, B.; Lopes, F.. "Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl) -1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate". Acta Crystallographica Section E: Structure Reports Online 65 2 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-60349087045&partnerID=MN8TOARS.
    10.1107/S1600536809000324
  30. Rodrigues, T.; Moreira, R.; Guedes, R.C.; Iley, J.; Lopes, F.. "Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design". Archiv der Pharmazie 341 6 (2008): 344-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-50949107913&partnerID=MN8TOARS.
    10.1002/ardp.200700250
  31. Chambel, P.; Capela, R.; Lopes, F.; Iley, J.; Morais, J.; Gouveia, L.; Gomes, J.R.B.; Gomes, P.; Moreira, R.. "Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design". Tetrahedron 62 42 (2006): 9883-9891. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748140661&partnerID=MN8TOARS.
    10.1016/j.tet.2006.08.026
  32. Araújo, M.J.; Bom, J.; Capela, R.; Casimiro, C.; Chambel, P.; Gomes, P.; Iley, J.; et al. "Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials". Journal of Medicinal Chemistry 48 3 (2005): 888-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444269006&partnerID=MN8TOARS.
    10.1021/jm0494624
  33. Lopes, F.; Capela, R.; Gonçaves, J.O.; Horton, P.N.; Hursthouse, M.B.; Iley, J.; Casimiro, C.M.; Bom, J.; Moreira, R.. "Amidomethylation of amodiaquine: Antimalarial N-Mannich base derivatives". Tetrahedron Letters 45 41 (2004): 7663-7666. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544220004&partnerID=MN8TOARS.
    10.1016/j.tetlet.2004.08.093
  34. Iley, J.; Lopes, F.; Moreira, R.. "Kinetics and mechanism of hydrolysis of N-amidomethylsulfonamides". Journal of the Chemical Society, Perkin Transactions 2 5 (2001): 749-753. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035528977&partnerID=MN8TOARS.
  35. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 6: N-acyloxymethyl- and N-[(aminocarbonyloxy)methyl]sulfonamides as prodrugs of agents containing a secondary sulfonamide group". Bioorganic and Medicinal Chemistry 8 4 (2000): 707-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034027024&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00015-8
  36. Iley, J.; Barroso, H.; Moreira, R.; Lopes, F.; Calheiros, T.. "Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: Chemical hydrolysis and anti-bacterial activity". Bioorganic and Medicinal Chemistry 8 7 (2000): 1629-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033936572&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00099-7
  37. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 5. Kinetics and mechanism of the hydrolysis of tertiary N-acyloxymethylsulfonamides". Journal of the Chemical Society. Perkin Transactions 2 3 (1999): 431-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037889702&partnerID=MN8TOARS.
  38. Calheiros, T.; Iley, J.; Lopes, F.; Moreira, R.. "Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-acyloxymethylsulfonamide prodrugs". Bioorganic and Medicinal Chemistry Letters 5 9 (1995): 937-940. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063007&partnerID=MN8TOARS.
    10.1016/0960-894X(95)00146-K
  39. Cruz, M.E.M.; Gaspar, M.M.; Lopes, F.; Jorge, J.S.; Perez-Soler, R.. "Liposomal l-asparaginase: in vitro evaluation". International Journal of Pharmaceutics 96 1-3 (1993): 67-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027222049&partnerID=MN8TOARS.
    10.1016/0378-5173(93)90213-Y
  40. Cruz, M.E.M.; Corvo, M.L.; Esteves, A.M.; Lopes, F.C.; Soler, R.P.. "Enzymatic liposomal formulations". European Journal of Pharmacology 183 2 (1990): 399-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025329294&partnerID=MN8TOARS.
    10.1016/0014-2999(90)93280-4

Intellectual property

Patent
  1. Magalhães e Silva, Diogo; Moreira, Rui; Lopes, Francisca; Rodrigues, Cecília; Marques, Vanda. 2023. "Drug delivery systems based on endoperoxides useful in diagnosis and therapy, and methods thereof". Portugal.
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/24 Uncovering novel chemotypes targeting the mycobacterial energy metabolism as a strategy to control tuberculosis 15th National Organic Chemistry Meeting (15ENQO) and the 8th National Medicinal Chemistry Meeting (8ENQT)
SPQ (Faro, Portugal)
2022/04/01 Lead optimization of azaaurones as novel chemotypes against Mycobacterium tuberculosis 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting -
SPQ (Lisboa, Portugal)
2020/01 Discovery and optimization of new compounds active against multi-drug resistant M. tuberculosis II Simpósio de Investigação em Tuberculose e Micobactérias não Tuberculosas em Portugal
FFUL (Lisboa, Portugal)
2019/11 Discovery of azaaurones as potent antimycobacterial agents XXV Encontro Galego-Português de Química
Colegio Oficial de Químicos de Galicia (Santiago de Compostela, Spain)
2019/03 Novos Fármacos para a Tuberculose I Simpósio Dia Mundial da Tuberculose
FFUL/SPP/SPDIMC (Lisboa, Portugal)
2016/06 A chemical drug delivery approach to improve antimalarial activity Parasitic Infections
Euro Sci Con (London, United Kingdom)
2016 Nanoencapsulation of tetraoxane-based double drugs with antileishamanial activity 3rd COST Action CM1307 Conference
(Madrid, Spain)
2014 Stuctural optimization of multi-stage acting endoperoxide-based hybrid antimalarials COST Action CM1307 Join Event
(Calvi, France)
2012 Dual-stage acting antimalarials Medicinal Chemistry and Malaria Workshop
(Lisboa, Portugal)
2012 Peroxide-based hybrid drugs: synthesis and antimalarial evaluation Organic and Medicinal Chemistry Workshop
(Lisboa, Portugal)
2009 Artemisinin-falcipain inhibitor hybrid molecules: a new approach to dual acting antimalarial 2º Encontro da Plataforma Ibérica da Malária
GSK, Tres Cantos (Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/11/01 - Current Development of chemical tools to profile the target engagement of nitro 5-membered ring heterocycles against Mycobacterium tuberculosis
Supervisor
 Ciências Farmacêuticas (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11/01 - Current A multi targeting approach to tackle latency in tuberculosis
Supervisor
 Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/10/01 - Current Structural optimization of hybrid quinolinimine to target the mycobacterial energy metabolism
Supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Current Otimização Estrutural de quinoloniminas para atuação ao nível do metabolismo energético do Micobcterium tuberculosis
Supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Current The energetic metabolism of Mycobacterium tuberculosis as a target for the development of anti-tuberculosis drugs: new and promising approaches
Co-supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - Current Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Co-supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - Current Development of new drug leads for tuberculosis
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11 - 2024/11 Targeting the energy metabolism of Mycobacterium tuberculosis
Supervisor
 Pharmacy, Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/22 - 2022/12 Smart hydrid compounds to target the respiratory electron transport chain (ETC) of Mycobacterium tuberculosis
Supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11 - 2021/11 Desenvolvimento de moléculas híbridas tendo como alvo a cadeia respiratória do Mycobacterium tuberculosis
Supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2021/05 Development of artemisinin-vinyl sulfone hybrid drugs with potential antitumoral activity
Supervisor
 Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2020 Hit optimization to improve aqueous solubility of compounds with antimycobacterial activity
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Development of new neutrophil elastase inhibitors for topical formulation with improved therapeutic efficacy
Supervisor
 Mestrado de Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2019 Desenvolvimento de fármacos híbridos antitumorais direccionados para o lisossoma
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/09 - 2018/12 Chemical Interrogation of the protein cysteinome of malaria liver stage: from covalent inhibitors to bioorthogonal clickable probes Posdoctoral researcher
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Synthesis and identification of tetraoxane-based hybrid compounds as antileishmanials
Co-supervisor
Universiteit Antwerpen Departement Farmaceutische Wetenschappen, Belgium
2016 - 2017 Inducing oxidative stress in parasites: novel hybrid compounds based on peroxides to trap catalytic cysteine residues
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 Tetraoxanes as Chemical Drug Delivery Systems
Co-supervisor
2015 - 2016 Nanoencapsulation of New Compounds with Potential Anti-Leismanial Activity
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2016 Optimização de Compostos de Quinolina para Doenças Negligenciadas. Bloqueio de Vias de Metabolização
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01 - 2014/10 A mass spectrometry approach to unravel the metabolic pathways of antimalarial hybrid compounds. Postdoctoral researcher
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Synthesis and characterization of a hybrid compound with potential antimalarial activity
Co-supervisor
 Erasmus. University Liège (Master)
2010 - 2014 Peroxide-based hybrid and prodrug antimalarials to deliver cysteine protease inhibitors into the parasitic food vacuole
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Síntese de novos compostos híbridos com atividade antimalárica
Supervisor
2011 - 2012 Development of hybrid antimalarial compounds with peroxide and 8-aminoquinoline pharmacophores as candidates for malaria erradication
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2012 Compostos Híbridos da Artemisinina. Direccionamento para as fases sanguínea e hepática do parasita da malária
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010 Novel Mitochondrial Electron Transport-Chain Inhibitors as Potential Antimalarial Agents
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2006 Síntese e avaliação de derivados da amodiaquina
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/02/05 Combining synthesis inspired in natural products and nanotechnology: a rational strategy to treat biofilm infections
(Thesis) Main arguer
 Daniela Loureiro (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/12/21 Temporospatial Tuned Protein Degradation Using Light-Controllable PROteolysis-TArgeting Chimeras (PROTACS)
(Thesis) Arguer
 Anastasiya Voloshchuk (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/04/26 Flavones, Chalcones and Diarylpentanoids as Antitumor Agents: Discovery, Optimization and Structure-activity Relationship Studies
(Thesis) Main arguer
 Joana Moreira (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/02/01 Target-based and Phenotypic Studies towards the Discovery of Antimicrobial Adjuvants
(Thesis) Main arguer
 Fernando André Pereira Marques Durães (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/11/02 PREPARATION AND BIOLOGICAL EVALUATION OF NEW TRITERPENOID DERIVATIVES OF GLYCYRRHETINIC ACID
(Thesis) Main arguer
 Daniela Pereira Santana Alho (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022 Desenvolvimento de novos inibidores da necroptose direcionados à RIP1
(Thesis) Arguer
 Beatriz Chaves Cambaio (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Supervisor
 Diogo Maria Trindade Fonseca Magalhães e Silva (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/06 Synthesis and neuroprotection studies of new xanthenes and fluorenes
(Thesis) Main arguer
 Márcia Sofia Silva Martins (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/06/29 Genetic determinants of malaria therapeutics’ cross resistance with novel compounds
(Thesis) Arguer
 Carla Sofia Martins Calçada (PhD)
Universidade do Minho Escola de Medicina, Portugal
2021/04/09 Síntese e Avaliação Biológica de Novos Compostos Antitumorais Derivados de Triazenos
(Thesis) Main arguer
 Catarina Teixeira António (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12 Preparation and Preclinical Evaluation of New Ursane-type Triterpenoids
(Thesis) Main arguer
 Ana Sofia de Castro Valdeira (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/06/03 Hit optimization to improve aqueous solubility of compounds with antimycobacterial activity
Supervisor
 Elisabete Cristina Silva Freitas (Master)
2017/12 Doutoramento
(Thesis) Main arguer
 Sandra Antónia Cordeiro Figueiredo (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/07 Doutoramento
(Thesis) Main arguer
 Francesco Montalbano (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 Doutoramento
(Thesis) Arguer
 Marta Andreia Pais Carrasco (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 Doutoramento
(Thesis) Arguer
 Catarina Alexandra Batista Rodrigues (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/07 Doutoramento
Supervisor
 Rita Sofia Salvador Simões Capela (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/12 Doutoramento
Supervisor
 Tiago Correia de Oliveira Rodrigues (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/11 Doutoramento
(Thesis) Arguer
 João Paulo Martins Ferreira Lavrado (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/07 Doutoramento
(Thesis) Arguer
 Célia Maria Cardona Faustino (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007/10 Doutoramento
(Thesis) Arguer
 Ana Júlia Pinto Fonseca Seuve Afonso Rodrigues (PhD)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 Doutoramento
(Thesis) Arguer
 Luísa Cristina Dias Martins (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/05 Doutoramento
(Thesis) Main arguer
 Daniel André Botelho da Silva (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005/02 Doutoramento
(Thesis) Arguer
 Ana Paula Gameiro Francisco (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019/05 The topic of the interview was the challenges that tuberculosis drug discovery faces today. In addition, the development of new compounds for tuberculosis active against multi-resistant tuberculosis through the research project funded by FCT and developed in the Faculty of Pharmacy, was also adressed. News Farma Revista SIDA

Mentoring / Tutoring

Topic Student name
2016 - 2027 Design synthesis and biological evaluation of new antiplasmodial compounds related to ellagic acid Bernardo Santos Brasil
2016 - 2017 Analogues of the Antimicrobial Peptide BP214 Catarina Rainho Coelho
2016 - 2017 Tuberculose: Tratamento atual e novos fármacos em estudo Joana Brígida Fonseca Luís
2016 - 2017 Malária. Tratamento e Prevenção. Consulta do viajante. Nikolay Nikolaev Tomov
Distinctions

Other distinction

2015 Sabbatical fellowship for a research visit to the Molecular Mycobacteriology Research Unit and Drug Discovery and Development Centre , University of Cape Town
1997 Fellowship to attend the Winter School on Organic Reactivity (WISOR VI), Bressanone.
1987 Fellowship for a research visit to the MD Anderson Hospital Texas University