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I am a curious and ambitious young scientist who graduated in Biochemistry at the Faculty of Sciences, University of Lisbon (FC/ULisboa), which provided me with fundamental knowledge and skills and incited my curiosity and interest in scientific findings and teamwork. I recently completed my master's degree in Biopharmaceutical Sciences from the Faculty of Pharmacy, University of Lisbon (FF/ULisboa). Where, under the tutelage of Prof. João Gonçalves, I developed my Thesis project who aimed to characterize the immune responses triggered by SARS-CoV-2 and find patterns associated with the quality and amplitude of the immune response in severe COVID-19 patients. The results from my Thesis have already been submitted to publication. Currently, I am working as a Research Assistant in the Molecular Microbiology and Biotechnology group at the Research Institute for Medicines (iMed.ULisboa), the R&D Unit of FF/ULisboa that promotes pharmaceutical research to improve human health through disease prevention, diagnosis, and treatment. I consider myself an organized, responsible, and dedicated person, who loves a good challenge.
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Identification

Personal identification

Full name
Carolina Santos Palma

Citation names

  • S. Palma, Carolina

Author identifiers

Ciência ID
381E-624A-390A

Telephones

Mobile phone
  • 962269882 (Personal)

Addresses

  • Praça Afrânio Peixoto, nr 11, 3º Direito, 1000-009, Lisboa, Lisbon, Portugal (Personal)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1)
Education
Degree Classification
2022/01/01 - 2025/12/31
Ongoing
 Pharmacy (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/19 - 2021/02/25
Concluded
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Evaluation of the immune response to SARS-CoV-2 in ICU patients with COVID-19" (THESIS/DISSERTATION)
 17
2014/06/14 - 2018/07/06
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 13
Affiliation

Science

Category
Host institution 		Employer
2021/03/01 - 2022/12/31 Research Assistant (Research) Universidade de Lisboa - Associação para o Desenvolvimento do Ensino e Investigação da Microbiologia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2020 - Current Exosomal Fat-Liver Axis in Non-Alcoholic Fatty Liver Disease: Function and Modulation
PTDC/MED-PAT/31882/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2023/01/01 - 2024/06/30 O papel dos microRNAs na resposta imunitária e celular á vacinação COVID-19 em doentes hepáticos
2022.08837.PTDC
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2021/12 Fat2LiverTGR5 - Targeting the adipose tissue to treat fatty liver: role of TGR5
HR17-00601
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Obra Social La Caixa
Ongoing
2020 - 2021/12 MicroRNAs como biomarcadores diagnósticos de la evolución del daño hepático y papel en la enfermedad en pacientes ancianos (OLD-HEPAMARKER
CENIE
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidad de Salamanca, Spain
European Commission
Ongoing
2020 - 2021/12 "Testar com Ciência e Solidariedade"
02/SAICT/2020
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020 - 2021/12 "Teste rápido, de baixo custo e reduzida complexidade para deteção do RNA do SARS-Cov-2"
009_595764409
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Damião, Madalena; Simao, Andre L.; Miguel Rodrigues, Pedro; Afonso, Marta B.; Santos, André; Rodrigues, José; Fernandes, Diogo A. E.; et al. "Hepatic miRNA expression in experimental models of metabolic dysfuction-associated steatotic liver disease". Paper presented in EALS SLD Summit 2025, Estoril, 2025.
  2. Rodrigues, José; Fernandes, Diogo A. E.; S. Palma, Carolina; Moura Henrique, Mariana; Miguel Rodrigues, Pedro; Castro, Rui E.; Simao, Andre L.. "Hepatocyte-derived extracellular vesicles carriyng miR-21 trigger muscle cell dysfunction". Paper presented in EALS SLD Summit 2025, Estoril, 2025.
  3. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Patients with chronic liver disease demonstrate an impaired SARS-CoV-2-specific cellular immune response". Paper presented in iMed.Ulisboa Posgraduate Meeting, Lisbon, 2024.
  4. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Alterações na imunidade celular induzidas pelas vacinas contra a COVID-19 em indivíduos com doença hepática crónica". Paper presented in Congresso Português de Hepatologia, Figueira da Foz, 2024.
  5. Simao, Andre L.; Henrique, Mariana Moura; Fernandes, Diogo; Rodrigues, Pedro M.; Afonso, Marta B.; Santos, André A.; S. Palma, Carolina; et al. "O microRNA-222-3p encontra-se aumentado na esteatose hepática associada à disfunção metabólica e a sua inibição previne a progressão da doença em murganhos". Paper presented in Congresso Português de Hepatologia, Figueira da Foz, 2024.
  6. Fernandes, Diogo A. E.; Moura Henrique, Mariana; Rodrigues, José; Brígido, Ana; S. Palma, Carolina; Maria Banales, Jesus; Izquierdo-Sanchez, Laura; et al. "A inibição do microRNA-21 melhora a actividade muscular em murganhos com esteatose hepática associada à disfunção metabólica". Paper presented in Congresso Português de Hepatologia, Figueira da Foz, 2024.
  7. Cardoso, Miguel G.; Gonçalves, A. M.; Godinho-Santos, Ana; S. Palma, Carolina; Sidhu, P.; Marinho, A.; Leite, J.R.S.; Goncalves, Joao. "The cellular and humoral effects of vitamin D high doses in ICU patients with COVID-19". Paper presented in 15th iMed.Ulisboa postgraduate students meeting, Lisboa, 2024.
  8. Fernandes, Diogo; Moura Henrique, Mariana; Rodrigues, José; Brígido, Ana; S. Palma, Carolina; Izquierdo-Sanchez, Laura; Maria Banales, Jesus; et al. "miR-21 ablation ameliorates skeletal muscle function in metabolic dysfunction-associated steatotic liver disease in vivo". Paper presented in 15th iMed.Ulisboa postgraduate students meeting, Lisboa, 2024.
  9. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Chronic liver disease patients present a weak SARS-CoV-2 specific cellular immune response". Paper presented in UEG Week Vienna 2024, Vienna, 2024.
  10. Fernandes, Diogo; Henrique, Mariana Moura; Rodrigues, José; Brígido, Ana; S. Palma, Carolina; Izquierdo-Sanchez, Laura; Maria Banales, Jesus; et al. "miR-21 ablation rescue skeletal muscle function in a mouse model of metabolic dysfunction-associated steatotic liver disease". Paper presented in UEG Week Vienna 2024, Vienna, 2024.
  11. Fernandes, Diogo A. E.; Moura Henrique, Mariana; Rodrigues, José; Brígido, Ana; S. Palma, Carolina; Izquierdo-Sanchez, Laura; Maria Banales, Jesus; et al. "Inhibition of miR-21 improves muscle activity in experimental metabolic dysfunction-associated steatotic liver disease". Paper presented in EASL Congress, 2024.
  12. S. Palma, Carolina; Henrique, Mariana Moura; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Changes in cellular immunity induced by COVID-19 vaccines in patients with chronic liver disease". Paper presented in EALS congress 2024, Milan, 2024.
  13. Henrique, Mariana Moura; Palma, Carolina; Simao, Andre L.; Godinho-Santos, Ana; Cardoso, Miguel; Fernandes, Diogo; Carvalhana, Sofia; et al. "Long-term cellular immune response to COVID-19 vaccination in patients with chronic liver disease". Paper presented in EALS, 2023.
  14. Simao, Andre L.; Fernandes, Diogo A. E.; Silva, D (Silva, Daniela; Cruz, Margarida; Afonso, Marta B.; Santos, Andre A.; Moura Henrique, Mariana; et al. "Role of TGR5 in fat-to-liver communication during NAFLD". Paper presented in International Liver Congress, Viena, 2023.
  15. Casado, Igor; S. Palma, Carolina; Cardoso, Miguel; Godinho-Santos, Ana; Rodrigues, Ana Clara; Trindade, Carlos; Fonseca, João Eurico; Goncalves, Joao. "Characterization of humoral and cellular immune responses in rheumatoid arthritis patients following BNT162b2 vaccination". Paper presented in iMed.Ulisboa Posgraduate Meeting, Lisbon, 2023.
  16. Simao, Andre L.; Palma, Carolina; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Presence of cirrhosis in chronic liver disease patients associates with a lower immune response to COVID-19 vaccines-a multicenter european study". Paper presented in International Liver Congress, London, 2022.
    Published
Conference poster
  1. Fernandes, DAE; Rodrigues, J.; Henrique, Mariana; Palma, Carolina; Izquierdo-Sanches, L; Banales, Jesus; Rodrigues, PM; Castro, Rui; Simão, AL. "miR-21 Ablation Rescues Skeletal Muscle Function in a Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease". Paper presented in UEG Week 2024, 2024.
  2. Fernandes, DAE; Henrique, Mariana; Rodrigues, J.; Brígido, Ana; Palma, Carolina; Banales, Jesus; Izquierdo-Sanchez, L; et al. "A inibição do miR-21 melhora a atividade muscular em murganhos com estratos hepática associada à disfunção metabólica". Paper presented in Congresso Português de Hepatologia 2024, 2024.
  3. Araújo, C; Palma, Carolina; Igor casado; Fontes, Pedro; Goncalves, Joao. "P076: Induction of neutralizing antibody protection against SARS-CoV-2 Delta and Omicron variants following mRNA booster (BNT162b2) dose in cohorts of Portuguese subjects.". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., 2022.
  4. Henrique, Mariana Moura; André L. Simão; Palma, Carolina; A. P. Alves; Araújo, C; Goncalves, Joao; Caeiro F; Castro, Rui. "P70: Reduced humoral imune response of liver transplanted recipients to COVID-19 vaccines". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, Faculty of Pharmacy Lisbon., 2022.
Journal article
  1. Acúrcio, Rita C.; Kleiner, Ron; Vaskovich-Koubi, Daniella; Carreira, Bárbara; Liubomirski, Yulia; Palma, Carolina; Yeheskel, Adva; et al. "Intranasal Multiepitope PD-L1-siRNA-Based Nanovaccine: The Next-Gen COVID-19 Immunotherapy". Advanced Science 11 40 (2024): https://doi.org/10.1002/advs.202404159.
    10.1002/advs.202404159
  2. André Lopes Simão; Palma, Carolina; Laura Izquierdo-Sanchez; Antonella Putignano; Angela Carvalho-Gomes; Andreas Posch; Paola Zanaga; et al. Corresponding author: Rui E Castro. "Cirrhosis associates with lower immune response to COVID-19 vaccines in patients with chronic liver disease: a multicenter European study". JHEP Reports (2022):
    Submitted
Thesis / Dissertation
  1. Palma, Carolina. "Evaluation of the immune response to SARS-CoV-2 in ICU patients with COVID-19". Master, Universidade de Lisboa Faculdade de Farmácia, 2021.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/14 "Chronic liver disease patients present a weak SARS-CoV-2-specific cellular immune response" UEG Week Vienna 2024
UEG (Vienna, Austria)
2023/07 "Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease" 14th iMed.Ulisboa postgraduate students meeting
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2022/07 "Presence of cirrhosis in chronic liver disease patients associates with a lower immune response to COVID-19 vaccines - a multicenter European study" 13th iMed.ULisboa meeting
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/01/01 - Current Research Assistant João Gonçalves Lab and Rui Castro Lab, iMed.ULisboa, FFULisboa
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2025/01/23 - 2025/01/25 EALS SLD Summit EALS SLD Summit 2025
European Association for the Study of the Liver, Portugal
2024/10/12 - 2024/10/15 United European Gastroenterology Week
Conference
 United European Gastroenterology Week 2024
United European Gastroenterology, Austria
2024/07/11 - 2024/07/12 iMed.Ulisboa postgraduate students meeting
Meeting
 15th iMed.Ulisboa postgraduate students meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/04/18 - 2024/04/20 Congresso Português de Hepatologia Congresso Português de Hepatologia 2024
Associação portuguesa para o estudo do Fígado (APEF), Portugal
2023/06/26 - 2023/06/26 iMed.Ulisboa postgraduate students meeting
Meeting
 14th iMed.Ulisboa postgraduate students meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/05/08 - 2023/05/12 FLxFlow Course: Basic & Advanced Principles and Applications of Flow Cytometry
Other
 Basic & Advanced modules of the 4th edition of FLxFlow Course: Principles and Applications of Flow Cytometry
Fundação Champalimaud, Portugal

Gulbenkian Institute for Molecular Medicine, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/04/13 - 2023/04/15 Congresso Português de Hepatologia Congresso Português de Hepatologia 2023
Associação portuguesa para o estudo do Fígado (APEF), Portugal
2023 - 2023 Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório, desenhado segundo as recomendações da FELASA para Categoria B e organizado pela Faculdade de Farmácia da Universidade de Lisboa em colaboração com a Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL)
Other
 Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2022/07/04 - 2022/07/05 iMed.Ulisboa postgraduate students meeting
Meeting
 13th iMed.Ulisboa postgraduate students meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 Webinar "Coronavirus Disease 2019 (COVID-19): Role of Serologic Testing in Diagnosis and Assessment of Viral Immunity" by David M. Engman, MD, Ph.D.
2021 - 2021 Webinar "Role of serology in the next phase of COVID-19 investigation and response" by Linfa Wang, Ph.D.
2021 - 2021 Webinar "Immune profiling of hospitalized COVID-19 patients" by Josephine Giles Ph.D.
2021 - 2021 Webinar "COVID-19 RNA and DNA vaccines" by Deborah Fuller, Ph.D.
2021 - 2021 Webinar "COVID-19: A Clinical Lab's Response to a Pandemic" by Omai Garner, Ph.D., D (ABMM)
2021 - 2021 E-Learning Course "SARS-COV-2 & COVID-19"- https://lisbonph.pt/curso-e-learning virologia/#Sobre - LisbonPH
2021 - 2021 Webinar Liver transplantation and COVID-19: a joint ESOT-ELITA, ILTS, and EASL project. https://easl.eu/covid-19-and-the-liver/
2021 - 2021 Webinar "COVID-19 and the liver"
2021 - 2021 Webinar "COVID-19, Obesity and Fatty Liver Disease" - https://easlcampus.eu/videos/covid-19-and-liver-obesity-and-fatty-liver-disease
2020 - 2020 Webinar "Putting the Cart Before the Horse: SARS-CoV-2 Antibody Tests" by David G. Grenache, Ph.D., MT(ASCP), D(ABCC)
2020 - 2020 Webinar "All antibodies are NOT created equal: Comprehensive profiling of SARS-CoV-2 antibodies" by Tuomas Knowles
2020 - 2020 Webinar "COVID-19 Serology Assays and Cell Therapy Strategies" by Fatima Amanat, Dean Lee, and Lior Raviv.
2020 - 2020 E-Learning Course UEG online course on "Biomarkers of Liver Disease" Authors: Rui E. Castro, Frank Tacke, Jesús M. Bañales https://ueg.eu/p/119
2019/03/01 - 2020 Volunteer COVID-19 Diagnostic center, iMed.ULisboa | FFULisboa
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019 - 2019 Cancer Talks
Seminar
 "Serendipities of Acquired Immunity" by Dr. Tasuku Honjo, Champalimaud Foundation, Lisbon, Portugal.
2019 - 2019 33rd European Immunogenetics and Histocompatibility Conference
Conference
 "Functional Immunogenetics: The Historical Challenge", Lisbon, Portugal.
2019 - 2019 Seminar Parkinson by APDPk - Associação Portuguesa de Doentes de Parkinson, Lisbon, Portugal.
2019 - 2019 Biochemistry Masterclass Seminar, Faculty of Sciences, University of Lisbon, Portugal. "Biology of membrane transport" by Graça Soveral
2019 - 2019 Webinar "Innovative Approaches in Integrated Therapies" | Brain, Cancer and Infections, Institute of Molecular Medicine, Faculty of Medicine of the University of Lisbon, Portugal.
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019 - 2019 Volunteer ANBIOQ - Associação nacional de Bioquímicos - Organization, Reception and provision of information in 33rd European Immunogenetics and Histocompatibility conference.
2018 - 2018 Biochemistry Masterclass Seminar, Faculty of Sciences, University of Lisbon, Portugal. "Cancer Immunology" by Bruno Silva-Santos

Mentoring / Tutoring

Topic Student name
2021/01/01 - 2022/07/01 Vacinação COVID-19: Resposta Imunitária Matilde Gambito
2021/06/01 - 2022/06/28 Characterization of Immunogenicity produced by COVID-19 Vaccines in Autoimmune Arthritic Diseases Igor Casado