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I am Rodrigo Barriga, currently pursuing a PhD in the Computational Medicinal Chemistry Lab (Rita Guedes’ Lab) at the Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon. My academic journey began at the Faculty of Sciences, University of Lisbon (FCUL), where I earned my bachelor's degree in Biochemistry in 2020, graduating as one of the top students in my class. During my studies, I was awarded the prestigious “Gulbenkian Mais” grant from the Gulbenkian Foundation, which supported me throughout both my bachelor's and master's degrees. I pursued a master’s degree in Biochemistry for Health at the NOVA School of Science and Technology and ITQB, where I developed my master’s thesis in Manuel Melo’s Multiscale Modeling Lab, entitled “Simulating Substrate Binding Sites in S. aureus Type II NADH Dehydrogenase (NDH-2).” Throughout my academic career, I have actively participated in national and international conferences, presenting my work at various prestigious events. I have received multiple academic merit awards and achieved significant accomplishments, including ranking 19th out of over 100 participants in the national Olimpíadas da Bioquímica (2019–2020), and earning a silver medal in the international iGEM (International Genetically Engineered Machine) competition in 2021. I have also been involved in various organizing committees for conferences and have contributed to several LGBTQ+ associations, reflecting my passion for advocacy and community involvement. In terms of technical skills, I would say I am an intermediate-level Python programmer, know how to use GROMACS for molecular dynamics simulations, have some skills in Chemioinformatics, and know how to use several software tools for macromolecular visualization (such as PyMOL, VMD, ChimeraX). Additionally, I am fluent in English and possess strong communication skills. On a personal level, I am highly committed, proactive, motivated, and curious. In my free time, I enjoy listening to music, binge-watching series, and spending time with my three dogs. Currently, I am conducting my PhD research at Rita Guedes’ Lab, focusing on the “Discovery of multi-targeting small-molecule agents targeting TIGIT and PD-L1 checkpoint pathways”. I have already mentored 3 bachelor's students and I am now mentoring a master's student. My work aims to identify a dual inhibitor of these immune checkpoints to develop novel cancer therapies. https://www.linkedin.com/in/rodrigo-barriga-alves-3332201a5/
Identification

Personal identification

Full name
Rodrigo Miguel de Sousa Barriga Alves
Date of birth
1999/05/20
Gender
Male

Citation names

  • Barriga, Rodrigo

Author identifiers

Ciência ID
381C-1072-CC11
ORCID iD
0000-0003-4439-1157

Email addresses

  • rodrigobarriga@edu.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2023/10 - 2027
Ongoing
Farmácia (Doutoramento)
Major in Medicinal and Pharmaceutical Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/03 - 2023/02
Concluded
Biochemistry for Health (Mestrado)
Major in Computacional Biophysics/Bioinformatics/Computational Biology
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Simulating substrate binding sites in the S. aureus Type II NADH Dehydrogenase" (THESIS/DISSERTATION)
18
2017/09/09 - 2020/08/31
Concluded
Biochemistry (Licenciatura)
Major in Biochemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
18
2014/09/01 - 2017/08/31
Concluded
Sciences and Techonology (Ensino secundário)
Major in Biologia e Geologia + Física e Química A
Escola Secundária Sebastião e Silva, Portugal
18
Projects

Grant

Designation Funders
2023/10/01 - 2027/09/30 Discovery of multi-targeting small-molecule agents targeting TIGIT and PD-L1 checkpoint pathways
2023.01201.BD
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Barriga, Rodrigo; Lotfi, Maryam; Pereira, Manuela M.; Manuel N. Melo. Corresponding author: Manuel N. Melo. "P-06.3-001 The analysis of Staphylococcus aureus' NDH-2 Coarse-Grain simulations might be the beginning to unveil a future therapeutical target". Paper presented in The Biochemistry Global Summit 25th IUBMB Congress 46th FEBS Congress 15th PABMB Congress, 2022.
    10.1002/2211-5463.13440
  2. Barriga, Rodrigo; Lotfi, Maryam; Pereira, Manuela M.; Manuel N. Melo. Corresponding author: Manuel N. Melo. "P49 The analysis of Staphylococcus aureus¿ NDH2 CoarseGrain simulations might be the beginning to unveil a future therapeutical target". Paper presented in 2nd Chem And Biochem Students Meeting, 2022.
  3. Barriga, Rodrigo; Lotfi, Maryam; Pereira, Manuela M.; Manuel N. Melo. Corresponding author: Manuel N. Melo. "P35 THE ANALYSIS OF STAPHYLOCOCCUS AUREUS¿ NDH2 COARSEGRAIN SIMULATIONS MIGHT BE THE BEGINNING TO UNVEIL A FUTURE THERAPEUTICAL TARGET". Paper presented in 2nd Meeting of Portuguese Young Biophysicists, 2022.
    10.5281/zenodo.6772805
  4. Barriga, Rodrigo; Lotfi, Maryam; Pereira, Manuela M.; Manuel N. Melo. Corresponding author: Manuel N. Melo. "P2 Parameterization of nucleotide cofactors and metabolites for the Martini 3 Coarse-Grain force field". Paper presented in VIII EJIBCE (Encontro de Jovens Investigadores de Biologia Computacional Estrutural), 2021.
Journal article
  1. Carlota Leonardo-Sousa; Rodrigo Barriga; Helena F. Florindo; Rita C. Acúrcio; R. C. Guedes. "Structural Insights and Development of Small Molecule Inhibitors Targeting TGF-ß Receptor I: A Comprehensive Review of Clinical Advances". Molecular Therapy Oncology (2025): http://dx.doi.org/10.1016/j.omton.2025.200945.
    10.1016/j.omton.2025.200945
Thesis / Dissertation
  1. "Simulating substrate binding sites in the S. aureus Type II NADH Dehydrogenase". Master, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2023. https://run.unl.pt/handle/10362/151163.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/07 Ligand-based drug design for novel TIGIT inhibitors in cancer therapy XV iMed.ULisboa Meeting
iMed.ULisboa (Lisbon, Portugal)
2024/05 "Designing the future of cancer immunotherapy: a computational strategy for dual inhibition of TIGIT and PD-L1 proteins" 4th Biophysics Festival
Universidade da Beira-Interior (Covilhã, Portugal)
2022/12/21 Oral presentation in the 3D-BioInfo-PT Meeting: "Simulating substrate binding sites in the S. aureus Type II NADH Dehydrogenase" 3D-BioInfo-PT Annual Meeting
Instituto de Tecnologia Química e Biológica António Xavier (Oeiras, Portugal)
2022/11 Parameterisation of nucleotides and quinones using Martini 3 force field parameters Martini developer's meeting
Martini Malta's group (Valletta, Malta)
2022/02 Simulating substrate binding sites in bacterial respiratory enzymes Jornadas Intercalares do Mestrado
Universidade Nova de Lisboa - Faculdade de Ciências e Tecnologias (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/07 - 2024/07 XV iMed.ULisboa Meeting (2024/07 - 2024/07)
Congress (Member of the Organising Committee)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/05 - 2024/05 4th Biophysics Festival (2024/05 - 2024/05)
Congress (Member of the Organising Committee)
Universidade da Beira Interior, Portugal
2022/12 - 2022/12 3D-BioInfo PT Workshops - December 19 and December 20; Workshops of Structural Computational Biology tools (2022/12/19 - 2022/12/20)
Workshop (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/12 - 2022/12 3D-BioInfo PT Meeting - December 21; National Meeting of Structural Computational Biology Portuguese groups (2022/12/21 - 2022/12/21)
Meeting (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/09 - 2022/09 Computational Biology workshop held at ITQB NOVA - member of the Organising Committee (3D-BioInfo-PT), in which applicants developed basic computational skills. (22nd and 23rd, September 2022) (2022/09/22 - 2022/09/23)
Workshop (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/07 - 2024/07 Poster: "Ligand-based drug design for novel TIGIT inhibitors in cancer therapy"
Congress
XV iMed.ULisboa Meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/06 - 2024/06 Visualizing Science with PyMOL 3
Workshop
Visualizing Science with PyMOL 3
Schrödinger GmbH, Germany
2024/05 - 2024/05 Poster: "Structural Insight into TIGIT inhibition for cancer treatment - a comprehensive review"
Congress
4th Biophysics Festival
Universidade da Beira Interior, Portugal
2024/04 - 2024/04 3D-BioInfo-PT Advanced Workshop
Workshop
3D-BioInfo-PT Advanced Workshop
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2024/02 - 2024/02 Poster: “TIGIT/PD-L1 dual inhibition: small molecules to fight cancer”
Congress
XVth Spanish-Portuguese Conference on Controlled Drug Delivery - New Horizons in Drug Delivery
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/01 - 2024/01 P01: "TIGIT/PD-L1 dual inhibition: finding small molecules to fight cancer"
Congress
15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting
Sociedade Portuguesa de Química, Portugal

Universidade do Algarve, Portugal
2023/12 - 2023/12 Workshop "Introduction to AI and Machine Learning for Biomedical Research"
Workshop
Introduction to AI and Machine Learning for Biomedical Research
VAIA - Flanders AI Academy, Netherlands
2023/11 - 2023/11 Workshop on Ageing and Cancer
Workshop
Ageing and Cancer
Sociedade Portuguesa de Bioquímica, Portugal
2023/08 - 2023/09 Introduction to Bioinformatics
Workshop
Introduction to Bioinformatics
2022/10 - 2022/10 Cambridge exam (C1, Advanced)
Other
LinguaSkill
Cambridge Assessment, United Kingdom
2022/07 - 2022/07 P-06.3-001: "The analysis of Staphylococcus aureus’ NDH-2 Coarse-Grain simulations might be the beginning to unveil a future therapeutical target"
Congress
IUBMB–FEBS–PABMB Congress
International Union of Biochemistry and Molecular Biology, Netherlands
2022/07 - 2022/07 P49: The analysis of Staphylococcus aureus’ NDH-2 Coarse-Grain simulations might be the beginning to unveil a future therapeutical target
Conference
2nd Chem And Biochem Students Meeting
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/10 - 2022/07 NowClub - C1: one year English course, in which I got a score of 18 out of 20
Other
NowClub
NowClub, Portugal
2022/06 - 2022/06 P35: "The analysis of Staphylococcus aureus' NDH-2 Coarse-Grain simulations might be the beginning to unveil a future therapeutical target"
Congress
2nd Meeting of Portuguese Young Biophysicists
Universidade de Aveiro, Portugal
2022/04 - 2022/04 Thesis Masterclass
Other
Thesis Masterclass
Speak and Lead, Portugal
2021/12 - 2021/12 Computational Biology Workshop at Coimbra (EJIBCE)
Workshop
VIII EJIBCE (Encontro de Jovens Investigadores de Biologia Computacional Estrutural)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/12 - 2021/12 Poster: "Parameterization of nucleotide cofactors and metabolites for the Martini 3 Coarse-Grain force field"
Congress
VIII EJIBCE (Encontro de Jovens Investigadores de Biologia Computacional Estrutural)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/03 - 2021/11 We got a silver medal. We were the only Portuguese team competing in this global synthetic biology contest, iGEM. We enrolled with the Microplastics theme. The main goal of this contest is to make aware of environmental issues and find ways to surpass them.
Other
iGEM
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/10 - 2021/10 VMD (Visual Molecular Dynamics) Workshop
Workshop
Visual Molecular Dynamics Workshop
Associação Nacional de Estudantes de Química, Portugal
2020 - 2020 1st Edition of the National Biochemistry Olympics - 19th place
Other
1st Edition of the National Biochemistry Olympics - 19th place
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03 - 2019/09 Encontro Nacional de Estudantes de Bioquímica (ENEBIOQ): a meeting of all Biochemistry students from all our country aiming networking, sharing ideas, etc. Forensics Toxicology workshop.
Meeting
Encontro Nacional de Estudantes de Bioquímica (ENEBIOQ)
Universidade de Aveiro, Portugal
2019/03 - 2019/03 Semana da Bioengenharia by Instituto Superior Técnico (IST). Prototyping and 3D printing workshop from JUNITEC. Electrocardiogram (ECG) workshop.
Workshop
Semana da Bioengenharia
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/03 - 2018/03 Emotional Intelligence Google - Fundação Calouste Gulbenkian; a workshop of self-knowledge and emotional management developed by Google (to Gulbenkian Mais grant holders)
Workshop
Emotional Intelligence Google
Fundação Calouste Gulbenkian, Portugal

Association member

Society Organization name Role
2023/01 - Current Portuguese Young Biophysicists - association in charged of organising the "Biophysics Festival" every year
2022/04 - Current SPB - Portuguese Biochemical Society or “Sociedade Portuguesa da Bioquímica” and SPBf, composed of members of the SPB that work in Biophysics - Portuguese Biophysics Society)
2018/05 - 2022/06 BioqUL Member of the former association of Biochemistry students from FCUL
2020/09 - 2022/05 NuPride LGBTQ+ association member from FCT
2018/05 - 2019/07 OutCiências LGBTQ+ association member from FCUL

Mentoring / Tutoring

Topic Student name
2024/02 - 2024/07 Bachelor's Project Afonso Machado and Carolina Rocha
2022/07 - 2022/07 Summer Science ITQB NOVA Guilherme Silva
Distinctions

Award

2021 Silver medal iGEM 2021
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020 1st Edition of the National Biochemistry Olympics - 19th place
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 Academic award 2018/2019 - 17.90 out of 20
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 Academic award 2017/2018 - 18.75 out of 20
Universidade de Lisboa Faculdade de Ciências, Portugal

Title

2017 Gulbenkian Mais Grant Holder
Fundação Calouste Gulbenkian, Portugal