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Beatriz Painho holds a BSc in Biology, from University of Lisbon and a Master in Biochemistry for Health, from Nova University of Lisbon. Her master thesis project aimed to explore hiPSC-derived 3D neural cultures to model Mucopolysaccharidosis type VII, in order to recapitulate the microenvironment of this ultra-rare disease. Currently, she is a Research Fellow at Instituto de Biologia Experimental e Tecnológica (iBET), involved in two main projects: one with the pharmaceutical industry and the CARDIOPATCH project. The latter aims to develop a scalable manufacturing strategy for the production of mesenchymal stromal cells (MSC) and MSC-derived extracellular vesicles with augmented cardiac potential.
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Identification

Personal identification

Full name
Beatriz Alexandra Carones Painho

Citation names

  • Painho, Beatriz
  • Painho, B.

Author identifiers

Ciência ID
3814-CFE6-6237

Email addresses

  • beatriz.painho@ibet.pt (Professional)
  • bpainho@gmail.com (Personal)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020/08 - 2021/07
Concluded
 Research Pratice Level 1 (Pós-Graduação)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 19
2020
Concluded
 Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Exploring induced pluripotent stem cell-derived 3D neural cultures to model Mucopolysaccharidosis type VII" (THESIS/DISSERTATION)
 17
2017
Concluded
 Biology - Branch of Molecular Biology and Genetics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2019/09 - Current Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Projects

Grant

Designation Funders
2023/05/01 - Current Next generation, off-the-shelf, non fraticide-directed CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia (carxall)
101113067
Research Fellow
European Innovation Council
Ongoing
2021/02 - 2023/04/30 CARDIOPATCH- Network of Excellence for the development of Advanced Therapies of Myocardial Infarction Treatment based on Regenerative Medicine and 3D Printing
SOE4/P1/E1063
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
European Regional Development Fund
Ongoing
2020/08 - 2022/12 Project with the Pharmaceutical Industry in Stem Cell Bioprocessing
-
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
Ongoing
2020/02 - 2020/07 Neurospheroids to model pathological neuroinflammation
iNOVA4Health.TL1.WP2
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
iNOVA4Health
Concluded
2019/09 - 2020/02 AstroReact - Unravelling the role of astrocyte-induced neural microenvironment remodelling in traumatic brain injury pathobiology
PTDC/BTM-ORG/29580/2017
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Marta Costa; Painho, Beatriz. Corresponding author: Marta Costa. "Real-time bioprocess monitoring for large-scale production of mesenchymal stromal cell-derived extracellular vesicles". Paper presented in ISCT 2023, 2023.
  2. Painho, Beatriz. "Scalable and transient gene expression in mesenchymal stromal cells expanded in stirred-tank bioreactors towards the treatment of myocardial infarction". Paper presented in ISCT 2023, 2023.
  3. Costa, Marta; Sousa, Carolina; Painho, Beatriz; Costa, Margarida; Pelacho, Beatriz; Prosper, Felipe; Arderiu, Gemma; et al. "Scalable production of metabolic and miRNA pre-conditioned mesenchymal stromal cells in a microcarrier-supported bioreactor towards the treatment of myocardial infarction". Paper presented in 27th Meeting of the European Society of Animal Cell Technology, 2022.
  4. Painho, Beatriz; Costa, Marta; Carrondo, Inês; Costa, Margarida; Fernandes, Rafael; Fayel, Maxime; Prats, Anne-Catherine; Roncalli, Jérome; Pelacho, Beatriz; Prosper, Felipe; Alves, Paula; Isidro, Inês; Serra, Margarida. "Advancing the manufacture of mesenchymal stromal cells-based products with augmented cardiac regenerative potential through genetic engineering and enhanced process control". Paper presented in 27th Meeting of the European Society of Animal Cell Technology, 2022.
  5. Costa, Marta; Painho, Beatriz; Costa, Margarida; Sousa, Carolina; Louro, Ana Filipa; Andreu-Oltra, Enrique; Fayel, Maxime; Pelacho, Beatriz; Prosper, Felipe; Prats, Anne-Catherine; Alves, Paula; Serra, Margarida. "Scalable and chemically-defined manufacturing of mesenchymal stromal cell-derived extracellular vesicles with augmented cardiac potential". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  6. Gomes, Catarina M.; Gonçalves, Carolina; Painho, Beatriz; Simão, Daniel; Brito, Catarina. "Exploring a human stem-cell derived 3D model to study astrocyte activation during neuroinflammation". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  7. Gomes, Catarina M.; Gonçalves, Carolina; Painho, Beatriz; Simão, Daniel; Brito, Catarina. "Exploring a human stem-cell derived 3D model to study astrocyte activation during neuroinflammation". Paper presented in EMBO Microglia 2021, 2021.
  8. Painho, Beatriz; Gonçalves, Carolina; Simão, Daniel; Terrasso, Ana Paula; Alves, Paula M.; Brito, Catarina. "hiPSC-derived neurospheroid models to address the role of neuronal microenviroment in neurological disorders". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
Journal article
  1. Costa, Marta H. G.; Costa, Margarida S.; Painho, Beatriz; Sousa, Carolina D.; Carrondo, Inês; Oltra, Enrique; Pelacho, Beatriz; et al. "Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell-derived extracellular vesicles in stirred-tank bioreactors". Biotechnology and Bioengineering (2023): http://dx.doi.org/10.1002/bit.28378.
    Published • 10.1002/bit.28378
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/20 - 2023/06/23 The gamma-delta conference featured 50 talks and 3 poster sessions, focused on unpublished data results from 6 fields of knowledge: Ligands & Repertoires, Development & Differentiation, Cancer Responses, Cancer Therapies, Infection and Tissues & Inflammation.
Conference
 10th International Gamma Delta Conference
2022/09/25 - 2022/09/29 The course addressed key bioprocessing aspects, analytical toolsets to assess the quantity and quality attributes, and regulatory challenges for the manufacturing of ATMPs, providing also a solid fundamental basis on vectorology and stem cell biology.
Other
 2nd Bioprocessing and Manufacturing of Gene and Cell Therapy Products Course
European Society for Animal Cell Technology (ESACT), Germany