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Ana Costa. Concluiu o(a) Mestrado integrado em Ciências Farmacêuticas em 2011/10/12 pelo(a) Instituto Universitário de Ciências da Saúde e Doutoramento em Ciências Biomédicas em 2018/06/15 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. É Pós-doutorado no(a) Universidade de Lisboa Instituto de Investigação do Medicamento. Publicou 15 artigos em revistas especializadas. Possui 1 capítulo(s) de livros e 1 livro(s). Recebeu 4 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Doutoramento em 1 projeto(s), Bolseiro de Investigação em 1 projeto(s) e Investigador em 1 projeto(s). Nas suas atividades profissionais interagiu com 51 colaborador(es) em coautorias de trabalhos científicos.
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Identification

Personal identification

Full name
Ana Margarida Martins Maia da Costa

Citation names

  • Costa, Ana

Author identifiers

Ciência ID
3717-DCA7-FB47
ORCID iD
0000-0003-3272-8365

Telephones

Mobile phone
  • 919643950 (Personal)

Addresses

  • Av. Professor Gama Pinto, 1649-003, Lisbon, Lisboa, Portugal (Professional)
  • Rua Central de Gandra, 57, 4585-116, Gandra, Paredes, Portugal (Personal)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Education
Degree Classification
2019/05/06 - 2019/05/17
Concluded
 Laboratory Animal Science Course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/02/01 - 2018/06/15
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Establishment of a three-dimensional in vitro model of air-blood barrier to assess the translocation of nanoparticles targeted to the lung" (THESIS/DISSERTATION)
 Aproved
2006/10/01 - 2011/10/12
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Instituto Universitário de Ciências da Saúde, Portugal
"Não se aplica" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2021/06/03 - Current Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2018/12/03 - 2021/06/02 Postdoc (Research) Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
(...)
2018/04/01 - 2018/11/30 Research Assistant (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/02/01 - 2018/03/31 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/02/01 - 2017/07/31 Visiting Researcher (Research) Helmholtz-Institut für Pharmazeutische Forschung Saarland, Germany
2015/11/01 - 2016/06/30 Visiting Researcher (Research) Helmholtz-Institut für Pharmazeutische Forschung Saarland, Germany
2013/10/01 - 2014/01/31 Research Assistant (Research) Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
(...)
2013/05/03 - 2013/09/30 Research Assistant (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
(...)

Others

Category
Host institution 		Employer
2011/06/01 - 2011/07/31 Estágio Curricular Centro Hospitalar Universitário de São João, Portugal
2011/03/01 - 2011/05/31 Estágio Curricular Farmácia Senhora da Guia, Portugal
2011/02/14 - 2011/02/28 Estágio Curricular Laboratório de Análises Clínicas do Vale de Sousa, Portugal
Projects

Grant

Designation Funders
2014/02 - 2018/06 Establishment of a three-dimensional in vitro model of air-blood barrier to assess the translocation of nanoparticles targeted to the lung
SFRH/BD/95227/2013
SFRH/BD/95227/2013
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/12/03 - Current Sustainable, Safe, and Scalable (3S) approach for lycopene valorization: driving the knowledge toward an academia-industry interface for topical treatment of inflammation
PTDC/SAU-SER/30197/2017
LISBOA-01-0145-FEDER-030197
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/04/01 - 2019/11/30 Development of oral strips containing nanoencapsulated bioactive compounds
PTDC/BBBNAN/3249/2014
Research Fellow
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/10/01 - 2014/01/31 Cutaneous leishmaniasis: an innovative idea to explore the topical treatment of skin lesions
EXPL/CVT-EPI/0862/2012
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2013/09/30 Lung CYD-DDS (cyclodextrin-based drug delivery systems) for inhalation
PTDC/SAU-FCF/098733/2008
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Simões, S.; Costa, A.; Faria-Silva, A.C.; Ascenso, A.; Marto, J.; Carvalheiro, M.; Gonçalves, L.M.; et al. "Sustainable valorization of food-processing industry by-products: challenges and opportunities to obtain bioactive compounds". In Valorization of Agri-Food Wastes and By-Products, 619-644. Elsevier, 2021.
    Published • 10.1016/b978-0-12-824044-1.00023-4
  2. Costa, Ana. "Nanoemulsions for cosmetic products". 59-77. Elsevier, 2020.
    10.1016/b978-0-12-822286-7.00004-8
  3. Soares, S; Costa, a; Fonte, P; Sarmento, Bruno. "Invasive versus noninvasive delivery of insulin". In Drug Delivery: An Integrated Clinical and Engineering Approach:, edited by Rosen, Y.; Gurman, P.; Elman, N., 101-146. CRC Press, 2017.
    Published
  4. Costa, A.; Andrade, F.. "Tissue-based in vitro and ex vivo models for pulmonary permeability studies". In Concepts and Models for Drug Permeability Studies, edited by Sarmento, Bruno, 255-272. Elsevier, 2015.
Conference poster
  1. Costa, Ana; Franca Congiu; Joana Marto; Sandra Simões; Helena Margarida Ribeiro. "Effect of oil content on the physical-chemical properties and in vitro release profile of microemulsions". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  2. Costa, Ana; Andreia Ascenso; Joana Marto; Manuela Carvalheiro; Lidia Gonçalves; Helena Margarida Ribeiro; Sandra Simões. "Assessing the anti-inflammatory properties of lycopene-enriched extracts formulated in topical microemulsions". Paper presented in I Bioactive Natural Products Research Meeting 2019 (Bio.Natural Meeting 2019), 2019.
  3. Costa, Ana; Andreia Ascenso; Joana Marto; Manuela Carvalheiro; Lídia Gonçalves; Helena Margarida Ribeiro; Sandra Simões. "Assessing the anti-inflammatory properties of lycopene-enriched extracts formulated in topical microemulsions". Paper presented in 49th European Society for Dermatological Research Annual Meeting, 2019.
  4. Marta Marques; Costa, Ana; Andreia Ascenso; Joana Marto; Lidia Gonçalves; Manuela Carvalheiro; Alexandra Paiva; et al. "Lycopene-enriched extracts formulated in topical formulations". Paper presented in 11th young iMED .Ulisboa Postgraduated & 4th i3DU Student Meeting, 2019.
  5. Costa, Ana; Cristiane de Souza Carvalho-Wodarz; Bruno Sarmento; Claus-Michael Lehr; Vitor Seabra. "Towards the characterization of a three-dimensional in vitro alveolar model to test nanocarriers translocation". Paper presented in 10th World Congress Alternatives and Animal use in the Life Science, 2017.
  6. Costa, Ana; Stephanie Kletting; Cristiane de Souza Carvalho-Wodarz; Claus-Michael Lehr; Bruno Sarmento; Vitor Seabra. "Assessing the permeability of nanocarriers across the in vitro alveolar epithelium". Paper presented in 5th I3S Annual Meeting, 2016.
  7. Costa, Ana; Stephanie Kletting; Cristiane de Souza Carvalho-Wodarz; Vitor Seabra; Bruno Sarmento; Claus-Michael Lehr. "Assessing the permeability of nanocarriers across the in vitro alveolar epithelium.". Paper presented in BioBarriers 2016 - 11th Conference and Workshop on Biological Barriers, 2016.
  8. Sandra Soares; Pedro Fonte; Costa, Ana; José Carlos Andrade; Vitor Seabra; Domingos Ferreira; Reis, Salette; Bruno Sarmento. "Freeze-drying approaches for overcoming instability of insulin encapsulated into solid lipid nanoparticles". Paper presented in Nanoscience and Nanotechnology International Conference – NanoPT, 2015.
  9. Pedro Fonte; Sandra Soares; Costa, Ana; José Carlos Andrade; Vitor Seabra; Domingos Ferreira; Salette Reis; Bruno Sarmento. "Structural stability of proteins encapsulated into PLGA nanoparticles". Paper presented in .º Encontro de Investigação Jovem da Universidade do Porto – IJUP, 2015.
  10. Costa, Ana; Vitor Seabra; Bruno Sarmento. "Production and Characterization of Isoniazid-Loaded SLN for Tuberculosis Treatment". Paper presented in 4th I3S Annual Meeting. 30-31 de Outubro de 2014, 2014.
  11. Sandra Soares; Pedro Fonte; Costa, Ana; Vitor Seabra; Salette Reis; Bruno Sarmento. "A multivariate approach to evaluate freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin loaded into solid lipid nanoparticles". Paper presented in 32ª Reunião Anual do Colégio de Indústria, 2014.
  12. Sandra Soares; Pedro Fonte; Costa, Ana; Bruno Sarmento. "Freeze-drying of insulin-loaded solid lipid nanoparticles: from morphology to protein structure". Paper presented in Design and Industrial Development of Advanced Drug Delivery Systems, 2013.
  13. Pedro Fonte; Sandra Soares; Costa, Ana; José Carlos Andrade; Vitor Seabra; Domingos Ferreira; Reis, Salette; Bruno Sarmento. "Freeze-drying of insulin-loaded PLGA nanoparticles: the effect of cryoprotectants on particles stability". Paper presented in 4th International Congress: Nanotechnology, Medicine & Biology, 2013.
Journal article
  1. "Sustainable Valorization of Tomato By-Products to Obtain Bioac-Tive Compounds: Their Potential in Inflammation and Cancer Management". Molecules 27 5 (2022): 1701-1701. http://dx.doi.org/10.3390/molecules27051701.
    10.3390/molecules27051701
  2. Costa, Ana; Marques, Marta; Congiu, Franca; Paiva, Alexandre; Simões, Pedro; Ferreira, António; Bronze, Maria Rosário; et al. "Evaluating the Presence of Lycopene-Enriched Extracts from Tomato on Topical Emulsions: Physico-Chemical Characterization and Sensory Analysis". Applied Sciences 11 11 (2021): 5120. http://dx.doi.org/10.3390/app11115120.
    10.3390/app11115120
  3. Costa, Ana. "Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity". International Journal of Molecular Sciences 22 1 (2020): 242-242. http://dx.doi.org/10.3390/ijms22010242.
    10.3390/ijms22010242
  4. Costa, Ana. "Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs". Advanced Drug Delivery Reviews (2020): http://dx.doi.org/10.1016/j.addr.2020.09.008.
    10.1016/j.addr.2020.09.008
  5. Costa, Ana. "Lycopene in human health". LWT 127 (2020): 109323-109323. http://dx.doi.org/10.1016/j.lwt.2020.109323.
    10.1016/j.lwt.2020.109323
  6. Costa, Ana. "Evaluation of Lipid Nanoparticles for Topical Delivery of Protocatechuic Acid and Ethyl Protocatechuate as a New Photoprotection Strategy". International Journal of Pharmaceutics (2020): http://dx.doi.org/10.1016/j.ijpharm.2020.119336.
    10.1016/j.ijpharm.2020.119336
  7. Faria-Silva, C.; Ascenso, A.; Costa, A.M.; Marto, J.; Carvalheiro, M.; Ribeiro, H.M.; Simões, S.. "Feeding the skin: A new trend in food and cosmetics convergence". Trends in Food Science and Technology 95 (2020): 21-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075080873&partnerID=MN8TOARS.
    10.1016/j.tifs.2019.11.015
  8. Costa, Ana. "Stabilization of bluish pyranoanthocyanin pigments in aqueous systems using lignin nanoparticles". Dyes and Pigments (2019): http://dx.doi.org/10.1016/j.dyepig.2019.03.020.
    10.1016/j.dyepig.2019.03.020
  9. Costa, Ana. "Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.". Acta biomaterialia (2019): https://doi.org/10.1016/j.actbio.2019.04.037.
    10.1016/j.actbio.2019.04.037
  10. Abeer, M.M.; Meka, A.K.; Pujara, N.; Kumeria, T.; Strounina, E.; Nunes, R.; Costa, A.; et al. "Rationally designed dendritic silica nanoparticles for oral delivery of exenatide". Pharmaceutics 11 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073332977&partnerID=MN8TOARS.
    10.3390/pharmaceutics11080418
  11. Duy-Khiet Ho; Ana Costa; Chiara De Rossi; Cristiane de Souza Carvalho-Wodarz; Brigitta Loretz; Claus-Michael Lehr. "Polysaccharide Submicrocarrier for Improved Pulmonary Delivery of Poorly Soluble Anti-infective Ciprofloxacin: Preparation, Characterization, and Influence of Size on Cellular Uptake". Molecular Pharmaceutics 15 3 (2018): 1081-1096. https://doi.org/10.1021%2Facs.molpharmaceut.7b00967.
    10.1021/acs.molpharmaceut.7b00967
  12. Ana Costa; Bruno Sarmento; Vítor Seabra. "Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages". European Journal of Pharmaceutical Sciences (2017): https://doi.org/10.1016%2Fj.ejps.2017.12.006.
    10.1016/j.ejps.2017.12.006
  13. Fernanda Andrade; Pedro Fonte; Ana Costa; Cassilda Cunha Reis; Rute Nunes; Andreia Almeida; Domingos Ferreira; Mireia Oliva; Bruno Sarmento. "Pharmacological and toxicological assessment of innovative self-assembled polymeric micelles as powders for insulin pulmonary delivery". Nanomedicine 11 17 (2016): 2305-2317. https://doi.org/10.2217%2Fnnm-2016-0045.
    10.2217/nnm-2016-0045
  14. Ana Costa; Marina Pinheiro; Joana Magalhães; Ricardo Ribeiro; Vitor Seabra; Salette Reis; Bruno Sarmento. "The formulation of nanomedicines for treating tuberculosis". Advanced Drug Delivery Reviews 102 (2016): 102-115. https://doi.org/10.1016%2Fj.addr.2016.04.012.
    10.1016/j.addr.2016.04.012
  15. Ana Costa; Bruno Sarmento; Vítor Seabra. "Targeted Drug Delivery Systems for Lung Macrophages". Current Drug Targets 16 14 (2015): 1565-1581. https://doi.org/10.2174%2F1389450115666141114152713.
    10.2174/1389450115666141114152713
  16. Pedro Fonte; Sandra Soares; Flávia Sousa; Ana Costa; Vítor Seabra; Salette Reis; Bruno Sarmento. "Stability Study Perspective of the Effect of Freeze-Drying Using Cryoprotectants on the Structure of Insulin Loaded into PLGA Nanoparticles". Biomacromolecules 15 10 (2014): 3753-3765. https://doi.org/10.1021%2Fbm5010383.
    10.1021/bm5010383
  17. Nélio Drumond; André Sá Couto; Ana Costa; Helena Cabral-Marques. "Study of aerodynamic and release properties of inhaled particles containing cyclodextrins". Journal of Inclusion Phenomena and Macrocyclic Chemistry 80 1-2 (2014): 25-30. https://doi.org/10.1007%2Fs10847-014-0400-z.
    10.1007/s10847-014-0400-z
  18. Ana Costa; Bruno Sarmento; Vítor Seabra. "An evaluation of the latestin vitrotools for drug metabolism studies". Expert Opinion on Drug Metabolism & Toxicology 10 1 (2013): 103-119. https://doi.org/10.1517%2F17425255.2014.857402.
    10.1517/17425255.2014.857402
  19. Soares, S.; Fonte, P.; Costa, A.; Andrade, J.; Seabra, V.; Ferreira, D.; Reis, S.; Sarmento, B.. "Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles". International Journal of Pharmaceutics 456 2 (2013): 370-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886730036&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2013.08.076
  20. Pedro Fonte; Sandra Soares; Ana Costa; José Carlos Andrade; Vítor Seabra; Salette Reis; Bruno Sarmento. "Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying". Biomatter 2 4 (2012): 329-339. https://doi.org/10.4161%2Fbiom.23246.
    10.4161/biom.23246
  21. Soares, S.; Costa, A.; Sarmento, B.. "Novel non-invasive methods of insulin delivery". Expert Opinion on Drug Delivery 9 12 (2012): 1539-1558. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869786430&partnerID=MN8TOARS.
    10.1517/17425247.2012.737779

Other

Other output
  1. Invasive versus Noninvasive Delivery of Insulin. 2017. Sandra Soares; Ana Costa; Pedro Fonte; Bruno Sarmento; Soares, S.; Costa, A.; Fonte, P.; Sarmento, B.. https://doi.org/10.1201%2F9781315117584-6.
    10.1201/9781315117584-6
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/09/08 Is lycopene-enriched extracts from tomato waste an antioxidant strategy for skin protection? Sunset Skin Summit
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/05 From Garbage to Glamour: assessing the organoleptic properties of formulations containing lycopene-enriched extracts from Tomato Waste Natural Products Applications: Health, Cosmetic and Food
Instituto Politécnico de Bragança (On-line, Portugal)
2021/01/21 Assessing the tomato odor and the acceptability of microemulsions containing lycopene-enriched extracts from tomato processing residues Spanish Portuguese Local Chapter - Young Scientists Virtual Meeting
Control Release Society (Virtual Conference, Spain)
2019/08/29 Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier HIPS Symposium 2019
Helmholtz Centre for Infection Research (Saarbrucken, Germany)
2018/11/30 Three-dimensional in vitro model of air-blood barrier as a tool for evaluation the translocation of nanoparticles and the proinflammatory response 7th i3S Annual Meeting
i3S (Póvoa do Varzim, Portugal)
2018/05/07 The use of a three-dimensional in vitro alveolar model to test the translocation of nanocarriers and the proinflammatory response 1st Meeting in Biomedical Sciences
Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/09/08 - 2021/09/09 Organization of Sunset Skin Summit where iwas discussed the challenges and opportunities for the skin inflammation and stress oxidative, the skin neurobiology and the effect of Covid-19 pandemy on the skin health (2021/09/08 - 2021/09/09)
Seminar (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/11/27 Pharmaceutical Valorization of Tomato Processing Industry By-Products
(Thesis) Arguer
 Tânia Laranjeira (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Conference scientific committee

Conference name Conference host
2019/09/18 - 2019/09/21 49th European Society for Dermatological Research Annual Meeting Bordeux

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/09/20 - 2018/09/28 Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING (Curso de doutoramento (conclusão de unidades curriculares)) Instituto Universitário de Ciências da Saúde, Portugal
2017/09/21 - 2017/09/29 Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING (Curso de doutoramento (conclusão de unidades curriculares)) Instituto Universitário de Ciências da Saúde, Portugal
2016/09/27 - 2016/10/04 Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING Advanced Course: NANOTECHNOLOGY, DRUG DELIVERY AND DRUG TARGETING (Curso de doutoramento (conclusão de unidades curriculares)) Instituto Universitário de Ciências da Saúde, Portugal
Distinctions

Award

2019 HIPS EuroPhD
Helmholtz-Institut für Pharmazeutische Forschung Saarland, Germany
2018 Best Poster
2017 Travel award
2013 Travel award