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Isabel da Conceição Alves Alcobia Príncipe Henriques, concluiu o Doutoramento em Ciências Biomédicas em 2005, pela Faculdade de Medicina da Universidade de Lisboa e a Licenciatura em Biologia Microbiana e Genética em 1996 pela Faculdade de Ciências da Universidade de Lisboa. Desde 2007, exerce a sua atividade de docência como Professora Auxiliar no Instituto de Histologia e Biologia de Desenvolvimento da Faculdade de Medicina da Universidade de Lisboa. A sua área de investigação dedica-se ao estudo dos mecanismos celulares e moleculares envolvidos na diferenciação de células hematopoiéticas e na formação de órgãos linfóides como o timo. Autora de vários artigos científicos em revistas especializadas internacionais. Recebeu 1 prémio(s) e/ou homenagens. Highly dedicated and motivated biomedical researcher specialized in the field of cellular and developmental biology of hematopoietic cells and lymphoid organs. Currently, I have been involved in a project that aims to understand the cellular and molecular mechanisms involved in the thymus and parathyroid formation (PI Hélia Neves). Previous projects in which I was involved aimed: 1) to dissect the impact of IL7R gain-of-function mutations in T-cell leukemia and portray the landscape of IL-7/IL-7R signaling networks in health and malignancy (João Barata Lab, IMM-JLA), 2) understanding the role of Notch Signalling in the specification and differentiation of various cell types and tissues during embryogenesis, i.e. Hematopoietic, Thymic Epithelial and Endocrine-C cells (Instituto de Histologia e Biologia do Desenvolvimento, FML). During my PhD, I studied the spatial organization of the heterochromatin during the interphase of human cells.. Fisrt and co-author of several peer-reviewed scientific papers.
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Identification

Personal identification

Full name
ISABEL DA CONCEIÇÃO ALVES ALCOBIA PRÍNCIPE HENRIQUES

Citation names

  • Alcobia I
  • Isabel Alcobia

Author identifiers

Ciência ID
3714-0927-7AF1
ORCID iD
0000-0002-1861-4049
Google Scholar ID
https://scholar.google.com/citations?user=AF5sQdMAAAAJ&hl=pt-PT
Researcher Id
F-2081-2014

Email addresses

  • halcobia@medicina.ulisboa.pt (Professional)
  • isabel.henriques@gimm.pt (Professional)
  • halcobia@edu.ulisboa.pt (Professional)

Telephones

Fax
  • 217999527 (Professional)
Telephone
  • (+351) 21 7999528 Ext.: 47364 (Professional)

Addresses

  • Faculdade de Medicina da Universidade de Lisboa, Instituto de Histologia e Biologia do Desenvolvimento. Av. Prof Egas Moniz, Ed. Egas Moniz, IHBD Piso 3 Ala C, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2005
Concluded
 Doutoramento em Ciencias Biomédias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Spatial organisation of heterochromatin within the nucleus: a functional view of chromocenters in human hematopoietic cells" (THESIS/DISSERTATION)
 Aprovada com louvor e distinção - 18 valores
1996
Concluded
 Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 14 valores
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Researcher (Research) Gulbenkian Institute for Molecular Medicine, Portugal
2013/12/02 - 2024/09/30 Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2007/07/02 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2006/01/01 - 2013/12/01 Post-doc student Universidade de Lisboa Faculdade de Medicina, Portugal
2000/01/01 - 2005/05/31 Doctoral student Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2000/01/01 - 2004/04/30 ORGANIZAÇÃO ESPACIAL DA HETEROCROMATINA NO NÚCLEO: UMA VISÃO FUNCIONAL DE CROMOCENTROS EM CÉLULAS HUMANAS
PRAXIS XXI/BD/21438/99
 Fundação para a Ciência e a Tecnologia
Concluded
1997/03/01 - 1999/12/31 ORGANIZAÇÃO FUNCIONAL DE HETEROCROMATINA NO NÚCLEO. ANÁLISE DE CROMOCENTROS EM CÉLULAS HUMANAS
GGP XXI/BIC/4157/96
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2018/04 IL-7/IL-7R signaling networks in health and malignancy
info:eu-repo/grantAgreement/EC/H2020/648455/EU
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Ongoing
2013 - 2015 Dissecting the impact of IL7R gain-of-function mutations in T-cell leukemia
info:eu-repo/grantAgreement/FCT/3599-PPCDT/122428/PT
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2011/01/01 - 2014/06/30 Notch signalling in the specification and differentiation of thymic epithelial cells during embryogenesis.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/115264/PT
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2011/01/01 - 2014/06/30 Sinalização Notch na especificação e diferenciação das células epiteliais tímicas durante a embriogénese.
PTDC/SAU-BID/115264/2009
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Projecto Estratégico - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2012 Role of Notch Signalling in the Differentiation of Endocrine C cells during Embryogenesis.
projecto nº 441.00 - Pessoa Programme 2010-2011
Researcher
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Concluded
2008/04/01 - 2011/08/30 Sinalização Notch na hematopoiese e nicho hematopoiético embrionários.
PTDC/SAU-OBD/64165/2006
Post-doc
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/04/01 - 2011/08/30 Sinalização Notch na hematopoiese e nicho hematopoiético embrionários.
PTDC/SAU-OBD/64165/2006
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2006 Hoxb4 na formação de células estaminais hematopoieticas.
POCI/SAU-MMO/60419/2004
Post-doc Fellow
Instituto Gulbenkian de Ciência, Portugal
2000/01 - 2004/12 Organização 3D da heterocromatina no núcleo.
PRAXIS XXI/BIA/11011/1998
PhD Student Fellow
Universidade de Lisboa Instituto de Histologia e Biologia do Desenvolvimento, Portugal
Concluded
1997/01 - 1999/12 Topografia Nuclear e Rearranjos Moleculares de Genes Envolvidos em Translocações em Leucemia: Um Estudo em Fases Precoces da Diferenciação Hematopoiética
PRAXIS 2/2.1/SAU/1310/95
Scientific Initiation Fellow
Universidade de Lisboa Instituto de Histologia e Biologia do Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2016 - Current Identification of key moecular players in thymus development.
NA
Researcher
Universidade de Lisboa Instituto de Histologia e Biologia do Desenvolvimento, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Magalhães, L; Alcobia, I; Proa, Vitor; Gomes, E; Gama-Carvalho, Margarida; Neves, Hélia. "Identification of key moecular players in thymus development.". Paper presented in 10ª Edição-Dia da Investigação, Faculdade de Medicina da Universidade de Lisboa, Lisboa. 15 Dez., 2021.
  2. Ana Rita Teixeira; Edgar Gomes; Isabel Alcobia. "Exploring the role of the Notch ligand Delta-like 4 in mouse ESC exit from pluripotency.". Paper presented in 10ª Edição-Dia da Investigação, Faculdade de Medicina da Universidade de Lisboa, 2021.
  3. Monteiro, Luis; Alcobia I; Serafim, Teresa; Barata, Joao T.. "Exploring the IL-7 singling based on proteomics.". Paper presented in XIII PhD CAML Students Meeting., 2019.
  4. Figueiredo, Marta; Silva, Joana; Santos, Sofia; Proa, Vitor; Alcobia I; Dias, Sérgio; Zilhão, Rita; Cidadão, António; Neves, Hélia. "Notch and Hedgehog in thymus/parathyroid common primordium: a crossroad to organ formation.". Paper presented in 3rd Meeting of the Portuguese Society for Developmental Biology, 2015.
  5. Figueiredo, Marta; Silva, Joana; Santos, Sofia; Proa, Vitor; Alcobia I; Zilhão, Rita; Dias, Sérgio; Cidadão, António; Neves, Hélia. "Notch and Hedgehog in thymus/parathyroid common primordium: a crossroad to organ formation.". Paper presented in Thymus@Lisbon Symposium, 2015.
  6. Figueiredo, Marta; Silva, Joana; Santos, Sofia; Proa, Vitor; Alcobia I; Zilhão, Rita; Dias, Sérgio; Cidadão, António; Neves, Hélia. "Hh and Notch in thymus/parathyroids primordia development: Engaged partners?". Paper presented in IX PhD Students Meeting, Instituto de Medicina Molecular,, 2015.
  7. Alcobia I. "Differential effects of Notch signalling on the generation of hemangioblasts and erythro-myeloid progenitors.". Paper presented in 2º Encontro Anual da Sociedade Portuguesa de Biologia do Desenvolvimento, 2013.
  8. Alcobia I; Magalhães,Andreia S; Laranjeiro, Ricardo; Cidadão, António; Parreira, Leonor. "The role of Notch signaling during the development of endothelial and vascular smooth muscle progenitors.". Paper presented in EMBO Conference “Advances in Stem Cell Research: Development, Regeneration and Disease”, 2011.
  9. Alcobia I; Laranjeiro, Ricardo; Gomes, Andreia C.; Saavedra, Pedro; Zilhão, Rita; Cidadão, António; Parreira, Leonor. "Notch-signaling in ES-cell derived hematopoiesis.". Paper presented in Notch & Stem Cells Conference, 2010.
  10. Alcobia I; Laranjeiro, Ricardo; Gomes, Andreia C.; Saavedra, Pedro; Zilhão, Rita; Cidadão, António; Parreira, Leonor. "A stage specific biphasic role for Notch signaling in ES-cell derived hematopoiesis.". Paper presented in 7th Annual Meeting of the International Society for Stem Cell Research, 2009.
  11. Saavedra, Pedro; Alcobia I; Gomes, Andreia C.; Laranjeiro, Ricardo; Duarte, António; Cidadão, António; Parreira, Leonor. "The Notch-ligand Delta-4: a functional role in embryonic hematopoiesis.". Paper presented in Second National Meeting of Signal Transduction, 2008.
  12. Gomes, Andreia C.; Alcobia I; Parreira, Leonor; Cidadão, António. "Notch in embryonic hematopoiesis.". Paper presented in Keystone Symposia on Molecular and Cellular Biology: Stem Cell Interactions with their Microenvironmental Niche, 2007.
  13. Saavedra, Pedro; Alcobia I; Gomes, Andreia C.; Oliveira, Sonia; Duarte, António; Leonor Parreira; Cidadão A. "Haploinsufficiency of the Notch-ligand Delta 4 in ESC-derived embryoid bodies is associated with epithelial-mesenchymal transition and decreased hematopoietic potential in a gama-secretase independent manner.". Paper presented in 2nd International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2007.
  14. Alcobia I. "HoxB4 overexpression in mouse embryonic hematopoietic development.". Paper presented in British Societies for Cell and Developmental Biology, Joint Annual Meeting, 2006.
  15. Gomes, Andreia C.; Alcobia I; Oliveira, Sonia; Cidadão, António; Parreira, Leonor. "Notch signalling in mouse embryonic hematopoietic development.". Paper presented in British Societies for Cell and Developmental Biology, Joint Annual meeting, 2006.
  16. Alcobia I. "The spatial organisation of centromeric heterochromatin during normal human lymphopoiesis.". Paper presented in Alan Wolffe EMBO Workshop “Chromatin and Epigenetics”, 2003.
Journal article
  1. Isabel Alcobia; Margarida Gama-Carvalho; Leonor Magalhães; Vitor Proa; Sara Ferreira; Domingos Henrique; Hélia Neves. "Thymus-forming potential of the second pharyngeal pouch and its regulation by local mesenchyme in avian embryos". Cell Reports (2024): https://doi.org/10.1016/j.celrep.2024.114998.
    10.1016/j.celrep.2024.114998
  2. Teixeira, R. L.; da Silva Vieira, R.; Saavedra, M. J.; Polido-Pereira, J.; Moura, R. A.; Alcobia, I.; Fonseca, J. E.; Romão, V. C.. "Structured and prompt treatment of early arthritis in clinical practice leverages window of opportunity and leads to excellent clinical outcomes: an innovative retrospective cohort study". Clinical Rheumatology 43 12 (2024): 3941-3950. http://dx.doi.org/10.1007/s10067-024-07192-z.
    Published • 10.1007/s10067-024-07192-z
  3. Oliveira, Mariana L.; Akkapeddi, Padma; Alcobia, Isabel; Almeida, Afonso R.; Cardoso, Bruno A.; Fragoso, Rita; Serafim, Teresa L.; Barata, João T.. "From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia". Cellular Signalling 38 (2017): 10-25. http://dx.doi.org/10.1016/j.cellsig.2017.06.011.
    10.1016/j.cellsig.2017.06.011
  4. Figueiredo, Marta; Silva, Joana Clara; Santos, Ana Sofia; Proa, Vitor; Alcobia, Isabel; Zilhão, Rita; Cidadão, António; Neves, Hélia. "Notch and Hedgehog in the thymus/parathyroid common primordium: Crosstalk in organ formation". Developmental Biology 418 2 (2016): 268-282. http://dx.doi.org/10.1016/j.ydbio.2016.08.012.
    10.1016/j.ydbio.2016.08.012
  5. Laranjeiro, Ricardo; Alcobia, Isabel; Neves, Hélia; Gomes, Andreia C.; Saavedra, Pedro; Carvalho, Catarina C.; Duarte, António; Cidadão, António; Parreira, Leonor. "The Notch Ligand Delta-Like 4 Regulates Multiple Stages of Early Hemato-Vascular Development". PLoS ONE 7 4 (2012): e34553. http://dx.doi.org/10.1371/journal.pone.0034553.
    10.1371/journal.pone.0034553
  6. Alcobia, Isabel; Gomes, Andreia; Saavedra, Pedro; Laranjeiro, Ricardo; Oliveira, Sonia; Parreira, Leonor; Cidadao, Antonio. "Portrayal of the Notch System in Embryonic Stem Cell-Derived Embryoid Bodies". Cells Tissues Organs 193 4 (2011): 239-252. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288583000002&KeyUID=WOS:000288583000002.
    10.1159/000320572
  7. Alcobia, I; Quina, AS; Neves, H; Clode, N; Parreira, L. "The spatial organization of centromeric heterochromatin during normal human lymphopoiesis: Evidence for ontogenically determined spatial patterns.". Blood 102 11 (2003): 148B-148B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186537100591&KeyUID=WOS:000186537100591.
    10.1016/S0014-4827(03)00335-5
  8. Alcobia, I; Quina, AS; Neves, H; Clode, N; Parreira, L. "The spatial organization of heterochromatic compartments in human peripheral blood cells is established during hematopoietic differentiation". Blood 100 11 (2002): 150B-150B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000179184800628&KeyUID=WOS:000179184800628.
  9. Neves, H; Lucio, P; Alcobia, I; Clode, N; Parreira, L. "Differential role of Notch ligands Delta-1 and Jagged-1 in human hematopoietic progenitor cell differentiation.". Blood 100 11 (2002): 717A-717A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000179184702827&KeyUID=WOS:000179184702827.
  10. Alcobia, I; Quina, AS; Parreira, L. "Spatial organization of heterochromatin within the nucleus during hematopoietic differentiation.". Blood 98 11 (2001): 113B-113B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000172134200514&KeyUID=WOS:000172134200514.
  11. Alcobia I. "Spatial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type-specific organizational patterns.". Blood (2000): http://europepmc.org/abstract/med/10688815.
  12. Alcobia, I; Dilao, R; Parreira, L. "Spacial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type-specific organizational patterns". Blood 95 5 (2000): 1608-1615. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000085564700012&KeyUID=WOS:000085564700012.
  13. Alcobia, I.; Dilao, R.; Parreira, L.. "Spatial associations of centromeres in the nuclei of hematopoietic cells: Evidence for cell-type-specific organizational patterns". Blood 95 5 (2000): 1608-1615. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034161593&partnerID=MN8TOARS.
    10.1182/blood.v95.5.1608.005k32_1608_1615
  14. Alcobia, I; Dilao, R; Parreira, L. "Spatial associations of centromeres in the nucleus of normal hematopoietic cells: Evidence for cell-type-specific organizational patterns.". Blood 94 10 (1999): 137B-137B. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000083790700620&KeyUID=WOS:000083790700620.
Preprint
  1. Isabel Alcobia; Margarida Gama-Carvalho; Leonor Magalhães; Vitor Proa; Domingos Henrique; Hélia Neves. "Thymus formation in uncharted embryonic territories". 2022. https://doi.org/10.1101/2022.03.09.483697.
    10.1101/2022.03.09.483697
Report
  1. Simões, Irina Neves; Alcobia, Isabel. 2009. Caracterização fenotípica de populações celulares emergentes durante a diferenciação de corpos embrióides. http://hdl.handle.net/10451/3207.
Thesis / Dissertation
  1. Alcobia I. "Spatial organisation of heterochromatin within the nucleus: a functional view of chromocenters in human cells.". PhD, Universidade de Lisboa Faculdade de Medicina, 2005.
Distinctions

Other distinction

2000 1º Prémio LabMed