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Andreia Peixoto graduated in Biochemistry by the Faculty of Sciences UPorto in 2012 and completed her MSc degree in Biochemistry at the same institution in 2014, where she received a merit scholarship for exceptional academic performance. During her Master and PhD, Andreia Peixoto initiated her studies on cell-surface protein glycosylation associated with malignant transformations of the urinary bladder, envisaging biomarkers discovery for theragnostic applications. During her Master and PhD, as a member of Experimental Pathology and Therapeutics Group (IPO-Porto) and Tumour and Microenvironments Interactions group (INEB), she got familiarized with state-of-the-art in vitro techniques, trough the collaboration with IPATIMUP (Institute of Molecular Pathology and Immunology of the University of Porto). Currently, she is a Junior Researcher at IPO-Porto (CI-IPOP) and i3S, being focused on glycan-mediated immunosupressive mechanisms envisaging novel cancer immunotherapies. In this context, she has proficiency in glycomics and glycoproteomics workflows as well as in novel gene editing technologies and immuno-oncology. She is currently the principal investigator of an FCT funded project for cancer glycovaccines development (https://doi.org/10.54499/2022.03621.PTDC). She often lectures to BSc and MSc courses and actively participates in glycobiology meetings and workshops. She holds 2 book chapters, 1 international patent, and 29 publications (36% as first author; 1420 citations; H-index: 20) in relevant peer-reviewed journals in glycobiology/proteomics, oncoglycobiology, cancer biomarkers and therapeutics. As part of an Oncology Center of Excellence, her research presents a strong translational and market-oriented character, which is expected to translate into novel glycan-based cancer tools.
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Identification

Personal identification

Full name
ANDREIA FILIPA FERREIRA PEIXOTO

Citation names

  • Peixoto, Andreia

Author identifiers

Ciência ID
361D-5B5E-A5C1
ORCID iD
0000-0001-9514-0775

Email addresses

  • andreia.peixoto@ipoporto.min-saude.pt (Professional)

Telephones

Telephone
  • (+351) 225084000 Ext.: 5110 (Professional)

Addresses

  • Instituto Português de Oncologia do Porto (IPO-Porto). Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2025/03/10 - 2025/03/12
Attended
 International Course of Immunotherapy (Curso de Especialização Tecnológica)
Precision Immunology Institute at the Icahn School of Medicine, United States
2023/10/12 - 2023/10/12
Concluded
 Life Science Intellectual Property Management and Exploitation (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2023/06/13 - 2023/06/29
Concluded
 Research Project Management course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021 - 2021
Concluded
 Good Practices in In Vitro Research Course (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01/01 - 2020/10/15
Concluded
 Doctoral Degree in Biomedical Sciences (Doutoramento)
Major in Doctoral Degree
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Exploring glycobiomarkers for advanced stage bladder cancer: adding the influence of hypoxia to the equation" (THESIS/DISSERTATION)
 Summa Cum Laude
2018/03/19 - 2018/03/22
Concluded
 Descriptive statistics and SPSS course (Curso Técnico Superior Profissional)
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2015/09/07 - 2015/09/18
Concluded
 Course in laboratory animal science (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Category C
2013/10/24 - 2014/01/09
Concluded
 English B2.2 course (Curso médio)
Major in B2.2 (vantage)
Universidade do Porto Faculdade de Letras, Portugal
 B2.2 (vantage)
2014
Concluded
 Master's degree in Biochemistry (Mestrado)
Major in Master
Universidade do Porto Faculdade de Ciências, Portugal
"Hypoxic regulation of glycosylation in bladder cancer" (THESIS/DISSERTATION)
 18 valores
2012
Concluded
 First Degree in Biochemistry (Licenciatura)
Major in Bachelor
Universidade do Porto Faculdade de Ciências, Portugal
"Surfactant self-aggregation studies in aqueous solution and interaction with DNA" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2020/10/15 - Current Visiting Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/01/04 - 2030/01/01 Contracted Researcher (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2014/09/15 - 2015/09/15 Research Trainee (Research) TREAT U – Biotechnology, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022 - Current Tutor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03/01 - 2020/09/15 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2016/01/01 - 2020/10/15 PhD Student researching on the topic "Exploring glycobiomarkers for advanced stage bladder cancer: adding the influence of hypoxia to the equation" Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
(...)
2013/09/09 - 2014/12/22 MSc student researching for the MSc Thesis on the topic "Hypoxic regulation of Glycosylation in Bladder Cancer" in the Experimental Pathology and Therapeutics Group at IPO-Porto research center Universidade do Porto Faculdade de Ciências, Portugal
2011/09/01 - 2012/09/15 Bsc student researching for the BSc thesis in the Molecular Energetics, Colloids and Bio-interfaces group of the Centro de Investigação em Química da Universidade do Porto, CIQ(U.P.) Universidade do Porto Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2021/10/01 - Current Phosphoproteomics of hypoxic and glucose deprived bladder cancer cells: the missing link towards systems oncology.
#EPIC-XS-0000341
Researcher
Universiteit Utrecht, Netherlands
 European Proteomics Infrastructure Consortium Providing Access
Ongoing
2016/01/01 - 2030/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
2023.06366.CEECIND/CP2864/CT0001
Invited Scientist Fellow
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2025/02/01 - 2028/01/31 CAR T-Matters - Transforming the CAR T-cell therapy landscape in Portugal
18427
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 Fundo Europeu de Desenvolvimento Regional (FEDER)
Ongoing
2024/02/04 - 2025/02/04 GlycoGuard: Glycophenotyping Early Signs of Gastric Cancer Towards Life Saving Interventions
LPCC-NRN 2024
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Liga Portuguesa Contra o Cancro
Ongoing
2022/01/01 - 2024/12/31 RESOLVE: Rational Design of Multivalent Glycocode-Inspired Nanovaccines for Gastric Cancer Immunotherapy
PTDC/MED-OUT/2512/2021
10.54499/PTDC/MED-OUT/2512/2021
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 REVERENT: PRE-CLINICAL VALIDATION OF A GLYCOCODE-INSPIRED VACCINE FOR BLADDER CANCER IMMUNOTHERAPY
2022.03621.PTDC
10.54499/2022.03621.PTDC
Principal investigator
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/01/01 GlycoSensor: Pre-Clinical Validation of a Point-of-Care Biosensor for Cancer Detection in Whole Blood Based on Abnormal Glycosylation
0
Researcher
Universal Biosensors Pty Ltd, Australia
Concluded
2022/01/01 - 2023/01/01 glycoINSPIRER: PRE-CLINICAL VALIDATION OF A GLYCOCODE-INSPIRED VACCINE FOR BLADDER CANCER IMMUNOTHERAPY
LPCC-NRN 2022
Supervisor
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
Concluded
2020/05 - 2020/08 GLYCOVID-19 Testing existing glycan-based drugs to neutralize SARS-CoV- 2
140_596817822
Other
Fundação para a Ciência e a Tecnologia
Ongoing
2016/01 - 2020/01 Exploring glycobiomarkers for advanced stage bladder cancer: adding the influence of hypoxia to the equation
SFRH/BD/111242/2015
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2024/10/01 - 2030/09/30 NextGenGlycoVacs: Next generation glycovaccines for immunologically cold tumours
2023.06366.CEECIND/CP2864/CT0001
10.54499/2023.06366.CEECIND/CP2864/CT0001
Principal investigator
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2021 - 2025/12/31 RISE: Health Research Network: From Lab to Community Health
LA/P/0053/2020
Researcher
Ongoing
2024/09/01 - 2025/09/01 Deciphering the Influence of CD276 glycocode in Gastric Cancer Immunoregulation
ESS-IPP MSc
Supervisor
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Peixoto, Andreia; Cotton, Sofia; Santos, Lúcio Lara; Ferreira, José Alexandre. "The Tumour Microenvironment and Circulating Tumour Cells: A Partnership Driving Metastasis and Glycan-Based Opportunities for Cancer Control". In Advances in Experimental Medicine and Biology, 1-33. Springer International Publishing, 2021.
    Published • 10.1007/978-3-030-73119-9_1
  2. Peixoto, Andreia. "Alterações Moleculares no Cancro da Bexiga: Biomarcadores para Terapêutica Guiada". In Tumores Malignos- tracto genito-urinário, 217-226. Portugal: Grupo Português Génito-Urinário, 2016.
    Published
Conference paper
  1. Peixoto, Andreia. "Definindo o papel da glicosilação na agressividade do cancro de bexiga: Impacto do microambiente tumoral". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia – ENJIO, 2023.
    Published
Conference poster
  1. Lourenço, Camila; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Freitas, Rui; Peixoto, Andreia; Santos, Lúcio; Maria José Oliveira; Ferreira, José Alexandre. "GlycoMAPP - Exploring the Impact of Glycosylation on Macrophage Polarization in the Context of Tumour Progression". Paper presented in 2nd Young Researchers Day, 2024.
  2. Peixoto, Andreia; Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Ferreira, Eduardo; Cotton, Sofia; et al. "Definindo o papel da glicosilação na agressividade do cancro de bexiga: Impacto do microambiente tumoral". Paper presented in IPO-Porto Summit, 2024.
  3. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "Pre-clinical Validation of a Multivalent CD44 Glycoconjugate Vaccine for Cancer Immunotherapy". Paper presented in 1st Young Researcher's Day, 2023.
  4. Ferreira, Eduardo; Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Palmeira, Carlos; et al. "A Targeted and Self-Adjuvated PLGA MUC16-Tn Nanoglycovaccine Candidate for Cancer Immunotherapy". Paper presented in 1st Young Researcher's Day, 2023.
  5. Santos, Beatriz; Ferreira, Dylan; Relvas-Santos, Marta; Peixoto, Andreia; Santos, Lúcio; Ferreira, José. "Unravelling the glycomics signature of formalin-fixed paraffin-embedded gastric cancer tissues". Paper presented in 1st Young Researcher's Day, 2023.
  6. Soares, Janine; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Brandão, Andreia; Freitas, Rui; Ferreira, Eduardo; et al. "Glycosylation as a driver of Colorectal cancer aggressiveness". Paper presented in 1st Young Researchers¿s Day, 2023.
  7. Dourado-Gonçalves, Martina; Freitas, Rui; Ferreira, Dylan; Relvas-Santos, Marta; Paulo, Paula; Lara Santos, Lúcio; Ferreira, José Alexandre; Peixoto, Andreia. "Functional Glycoproteomics Characterization of Gastric Cancer Cells Expressing Immature O-Glycans". Paper presented in 1st Young Researcher's Day, 2023.
  8. Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Lara Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. "Exploiting Glycoengineered Simple Cells and Targeted O-glycoproteomics Towards Bladder Cancer Neoantigens". Paper presented in 1st Young Researchers' Day, 2023.
  9. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Gaiteiro, Cristiana; Ferreira, Eduardo; Relvas-Santos, Marta; Soares, Janine; et al. "Production and pre-clinical evaluation of immunogenic CD44 glycoconjugates: setting the molecular bases for novel multivalent anti-cancer glycovaccines". Paper presented in Trabalho apresentado no XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  10. Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Paulo, Paula; Castro, Flávia; et al. "Cancer-associated short-chain O-GalNAc glycans induce an immunosupressive bladder cancer phenotype by impairing dendritic cells function. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology.". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  11. Peixoto, Andreia. "Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation". Paper presented in 27th PORTO CANCER MEETING, 2021.
  12. Ferreira, Dylan; Freitas, Rui; Fernandes, Elisabete; Gaiteiro, Cristiana; Peixoto, Andreia; Cotton, Sofia; Palmeira, Carlos; et al. "Nucleolin-SLeA as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells: a flow cytometry-assisted approach". Paper presented in XVII Congress of the Iberian Society of Cytometry, 2021.
  13. Peixoto, Andreia. "Exploring the CA19-9 glycoproteome of Borrmann type IV advanced gastric cancer for guided therapeutics". Paper presented in 29th International Carbohydrate Symposium, 2018.
  14. Peixoto, Andreia. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension". Paper presented in 29th International Carbohydrate Symposium, 2018.
  15. Peixoto, Andreia; Fernandes, Elisabete; Gaiteiro, Cristiana; Lima, Luís; Azevedo, Rita; Soares, Janine; Cotton, Sofia; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation". Paper presented in 29th International Carbohydrate Symposium (ICS 2018) by Peixoto A, 2018.
  16. Peixoto, Andreia. "Humoral response against sialyl-Lea expressing glycoproteins in esophageal cancer: insights for immunoproteomic studies". Paper presented in Esophageal and Gastric Cancer Initiative, 2016.
  17. Peixoto, Andreia. "Abnormal Glycosylation in Borrmann Type IV gastric cancer: insight for guided therapeutics". Paper presented in Esophageal and Gastric Cancer Initiative, 2016.
  18. Peixoto, Andreia. "Emerging Antibody-Based Therapeutic Strategies For Bladder Cancer: A Systematic Review". Paper presented in 2nd ASPIC International Congress, 2016.
  19. Peixoto, Andreia. "Antibody-based Therapeutic Strategies in Clinical Trials for Bladder Cancer: A Systematic Review". Paper presented in Oncology Spring Meeting, 2016.
  20. Peixoto, Andreia. "Hypoxia induces bladder cancer cell invasion by antagonizing the extension of protein O-glycosylation". Paper presented in Oncology Spring Meeting, 2016.
  21. Peixoto, Andreia. "Abnormal protein glycosylation and activated PI3K/Akt/mTOR pathway: role in bladder cancer prognosis and targeted therapeutic". 2015.
  22. Peixoto, Andreia. "Abnormal glycosylation in Borrmann type Iv gastric cancer: insight for guided therapeutics". Paper presented in Oncology Spring Meeting, 2015.
Journal article
  1. Peixoto, Andreia; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Freitas, Rui; Veth, Tim S.; Brandão, Andreia; et al. "Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells". iScience (2025): 111758. https://doi.org/10.1016/j.isci.2025.111758.
    Open access • Published • 10.1016/j.isci.2025.111758
  2. Freitas, Rui; Ferreira, Eduardo; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Santos, Beatriz; et al. "Targeted and Self-Adjuvated Nanoglycovaccine Candidate for Cancer Immunotherapy". ACS Nano (2024): http://dx.doi.org/10.1021/acsnano.3c12487.
    Open access • Published • 10.1021/acsnano.3c12487
  3. Ferreira, Eduardo; Ferreira, Dylan; Relvas-Santos, Marta; Freitas, Rui; Soares, Janine; Azevedo, Rita; Afonso, Luís Pedro; et al. "Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer". International Journal of Molecular Sciences 25 6 (2024): 3462. http://dx.doi.org/10.3390/ijms25063462.
    Accepted • 10.3390/ijms25063462
  4. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "A multivalent CD44 glycoconjugate vaccine candidate for cancer immunotherapy". Journal of Controlled Release 367 (2024): 540-556. http://dx.doi.org/10.1016/j.jconrel.2024.01.065.
    Published • 10.1016/j.jconrel.2024.01.065
  5. Freitas, Rui; Peixoto, Andreia; Ferreira, Eduardo; Miranda, Andreia; Santos, Lúcio Lara; Ferreira, José Alexandre. "Immunomodulatory glycomedicine: Introducing next generation cancer glycovaccines". Biotechnology Advances 65 (2023): 108144. http://dx.doi.org/10.1016/j.biotechadv.2023.108144.
    Accepted • 10.1016/j.biotechadv.2023.108144
  6. Peixoto, Andreia; Miranda, Andreia; Santos, Lúcio Lara; Ferreira, José Alexandre. "A Roadmap for Translational Cancer Glycoimmunology at Single Cell Resolution". Journal of Experimental & Clinical Cancer Research (2022):
    10.1186/s13046-022-02335-z
  7. Cristiana Gaiteiro; Janine Soares; Marta Relvas-Santos; Andreia Peixoto; Dylan Ferreira; Andreia Brandão; Elisabete Fernandes; et al. "Glycoproteogenomics characterizes the CD44 splicing code driving bladder cancer invasion". Theranostics 12 7 (2022): 3150-3177. https://www.thno.org/v12p3150.htm.
    Published • 10.1101/2021.09.04.458979
  8. Peixoto, Andreia; Ferreira, Dylan; Azevedo, Rita; Freitas, Rui; Fernandes, Elisabete; Relvas-Santos, Marta; Gaiteiro, Cristiana; et al. "Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer". Journal of Experimental & Clinical Cancer Research 40 1 (2021): http://dx.doi.org/10.1186/s13046-021-01988-6.
    Open access • Published • 10.1186/s13046-021-01988-6
  9. Ferreira, José Alexandre; Relvas-Santos, Marta; Peixoto, Andreia; Silva, André M.N.; Santos, Lúcio Lara. "Glycoproteogenomics: Setting the Course for Next Generation Cancer Neoantigens Discovery for Cancer Vaccines". Genomics, Proteomics & Bioinformatics (2021): http://dx.doi.org/10.1016/j.gpb.2021.03.005.
    Open access • Published • 10.1016/j.gpb.2021.03.005
  10. Andreia Peixoto; Rui A Freitas; Dylan A Ferreira; Marta Relvas-Santos; Paula Paulo; Marta Cardoso; Janine Soares; et al. "Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation". (2021): https://doi.org/10.1101/2021.02.14.431133.
    10.1101/2021.02.14.431133
  11. Sofia Cotton; Dylan Ferreira; Janine Soares; Andreia Peixoto; Marta Relvas-Santos; Rita Azevedo; Paulina Piairo; et al. "Target Score: A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22041664.
    Published • 10.3390/ijms22041664
  12. Fernandes, Elisabete; Freitas, Rui; Ferreira, Dylan; Soares, Janine; Azevedo, Rita; Gaiteiro, Cristiana; Peixoto, Andreia; et al. "Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells". Cancers 12 4 (2020): 861. http://dx.doi.org/10.3390/cancers12040861.
    Published • 10.3390/cancers12040861
  13. Fernandes, Elisabete; Sores, Janine; Cotton, Sofia; Peixoto, Andreia; Ferreira, Dylan; Freitas, Rui; Reis, Celso A.; Santos, Lúcio Lara; Ferreira, José Alexandre. "Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology". Theranostics 10 11 (2020): 4903-4928. http://dx.doi.org/10.7150/thno.42480.
    Published • 10.7150/thno.42480
  14. Fernandes, Elisabete; Ferreira, Dylan; Peixoto, Andreia; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Martins, Gabriela; et al. "Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential". International Journal of Pharmaceutics 570 (2019): 118646. http://dx.doi.org/10.1016/j.ijpharm.2019.118646.
    Open access • Published • 10.1016/j.ijpharm.2019.118646
  15. Peixoto, Andreia; Relvas-Santos, Marta; Azevedo, Rita; Santos, Lúcio Lara; Ferreira, José Alexandre. "Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks". Frontiers in Oncology 9 (2019): http://dx.doi.org/10.3389/fonc.2019.00380.
    Open access • Published • 10.3389/fonc.2019.00380
  16. Neves, Manuel; Azevedo, Rita; Lima, Luís; Oliveira, Marta I.; Peixoto, Andreia; Ferreira, Dylan; Soares, Janine; et al. "Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications". New Biotechnology 49 (2019): 77-87. http://dx.doi.org/10.1016/j.nbt.2018.09.004.
    Published • 10.1016/j.nbt.2018.09.004
  17. Azevedo, Rita; Soares, Janine; Gaiteiro, Cristiana; Peixoto, Andreia; Lima, Luís; Ferreira, Dylan; Relvas-Santos, Marta; et al. "Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer". Talanta 184 (2018): 347-355. http://dx.doi.org/10.1016/j.talanta.2018.03.028.
    Published • 10.1016/j.talanta.2018.03.028
  18. Azevedo, Rita; Gaiteiro, Cristiana; Peixoto, Andreia; Relvas-Santos, Marta; Lima, Luís; Santos, Lúcio Lara; Ferreira, José Alexandre. "CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications". Clinical Proteomics 15 1 (2018): http://dx.doi.org/10.1186/s12014-018-9198-9.
    Published • 10.1186/s12014-018-9198-9
  19. Azevedo R; Soares J; Peixoto A; Cotton S; Lima L; Santos LL; Ferreira JA. "Circulating tumor cells in bladder cancer: Emerging technologies and clinical implications foreseeing precision oncology.". Urologic oncology (2018): http://europepmc.org/abstract/med/29530466.
    10.1016/j.urolonc.2018.02.004
  20. Peixoto, Andreia. "Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases.". Urologic oncology (2017): http://europepmc.org/abstract/med/28911924.
    10.1016/j.urolonc.2017.08.012
  21. Peixoto, Andreia. "Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?". Oncotarget (2017): http://europepmc.org/abstract/med/28767404.
    10.18632/oncotarget.19433
  22. Cotton, Sofia; Azevedo, Rita; Gaiteiro, Cristiana; Ferreira, Dylan; Lima, Luís; Peixoto, Andreia; Fernandes, Elisabete; et al. "Targeted O-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours". Molecular Oncology 11 8 (2017): 895-912. http://dx.doi.org/10.1002/1878-0261.12035.
    Published • 10.1002/1878-0261.12035
  23. Ferreira, José Alexandre; Magalhães, Ana; Gomes, Joana; Peixoto, Andreia; Gaiteiro, Cristiana; Fernandes, Elisabete; Santos, Lúcio Lara; Reis, Celso A.. "Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics". Cancer Letters 387 (2017): 32-45. http://dx.doi.org/10.1016/j.canlet.2016.01.044.
    Published • 10.1016/j.canlet.2016.01.044
  24. Peixoto, Andreia; Fernandes, Elisabete; Gaiteiro, Cristiana; Lima, Luís; Azevedo, Rita; Soares, Janine; Cotton, Sofia; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension". Oncotarget 7 39 (2016): 63138-63157. https://doi.org/10.18632/oncotarget.11257.
    Published • 10.18632/oncotarget.11257
  25. Peixoto, Andreia. "Abnormal glycosylation in Borrmann type IV gastric cancer: insight for guided therapeutics". Revista Portuguesa de Cirurgia 37 (2016): http://www.scielo.mec.pt/scielo.php?pid=S1646-69182016000400003&script=sci_arttext&tlng=es.
    Published
  26. Ferreira, José Alexandre; Peixoto, Andreia; Neves, Manuel; Gaiteiro, Cristiana; Reis, Celso A.; Assaraf, Yehuda G.; Santos, Lúcio Lara. "Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation". Drug Resistance Updates 24 (2016): 34-54. http://dx.doi.org/10.1016/j.drup.2015.11.003.
    Published • 10.1016/j.drup.2015.11.003
  27. Lima L; Gaiteiro C; Peixoto A; Soares J; Neves M; Santos LL; Ferreira JA. "Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies.". (2016): http://europepmc.org/abstract/med/27835695.
  28. Fernandes, Elisabete; Peixoto, Andreia; Neves, Manuel; Afonso, Luís Pedro; Santos, Lúcio Lara; Ferreira, José Alexandre. "Humoral response against sialyl-LeA glycosylated protein species in esophageal cancer: Insights for immunoproteomic studies". ELECTROPHORESIS 36 23 (2015): 2902-2907. http://dx.doi.org/10.1002/elps.201500270.
    Published • 10.1002/elps.201500270
  29. Azevedo R; Ferreira JA; Peixoto A; Neves M; Sousa N; Lima A; Santos LL. "Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review.". (2015): http://europepmc.org/abstract/med/26196222.
    10.1016/j.jconrel.2015.07.002
  30. Peixoto, Andreia. "New trends in guided nanotherapies for digestive cancers: A systematic review.". Journal of controlled release : official journal of the Controlled Release Society (2015): http://europepmc.org/abstract/med/25957905.
    10.1016/j.jconrel.2015.05.003
  31. Costa C; Pereira S; Lima L; Peixoto A; Fernandes E; Neves D; Neves M; et al. "Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.". (2015): http://europepmc.org/abstract/med/26569621.
  32. Santos, Júlio; Fernandes, Elisabete; Ferreira, José Alexandre; Lima, Luís; Tavares, Ana; Peixoto, Andreia; Parreira, Beatriz; et al. "P53 and Cancer-Associated Sialylated Glycans Are Surrogate Markers of Cancerization of the Bladder Associated with Schistosoma haematobium Infection". PLoS Neglected Tropical Diseases 8 12 (2014): e3329. http://dx.doi.org/10.1371/journal.pntd.0003329.
    Open access • Published • 10.1371/journal.pntd.0003329
Preprint
  1. Andreia Peixoto; Dylan Ferreira; Andreia Miranda; Marta Relvas-Santos; Rui Freitas; Tim S. Veth; Andreia Brandão; et al. "Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells". 2023. https://doi.org/10.1101/2023.10.21.561355.
    10.1101/2023.10.21.561355
  2. Peixoto, Andreia; Freitas, Rui; Ferreira, Dylan; Relvas-Santos, Marta; Paulo, Paula; Cardoso, Marta; Soares, Janine; et al. "Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation". 2021. http://dx.doi.org/10.1101/2021.02.14.431133.
    10.1101/2021.02.14.431133

Intellectual property

Provisional application for patent
  1. 2022. "Method for cancer detection, prognosis, and therapeutic selection based on short CD44 glycoproteoforms".
    Protected
  2. 2022. "CD44 glycoepitopes and chimeric vaccine glycoconjugates for cancer therapy and synthesis methods thereof".
    Protected

Other

Other output
  1. Hypoxia induces bladder cancer cell invasion by antagonizing the extension of protein O-glycosylation. 2015. Peixoto, Andreia. http://ijup.up.pt/2015/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/04/07 CD276 immature glycosylation drives colorectal cancer aggressiveness and T-cell-mediated immune escape IMMUNO-model Workshop: Harmonizing in vivo models of immunotherapy, past, present and future directions of WG
Bergen University (Bergen, Norway)
2023/11/09 Exploring the cancer glycocode for glycovaccines development 1st Young Researcher's day
IPO-Porto Research center (Porto, Portugal)
2023/05/12 Hypoxia and glucose deprivation induce bladder cancer cells dormancy and immature glycosylation driving cancer aggressiveness 29th Porto Cancer Meeting
i3S-Institute for Research & Innovation in Health (Porto, Portugal)
2023/04/12 Uncovering the Role of Glycosylation in Bladder Cancer Aggressiveness: Insights from the Tumor Microenvironment IPO-Porto Research Center Scientific Meeting
IPO-Porto Research center (Porto, Portugal)
2022/07/12 Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation 30th International Carbohydrate Symposium
International Carbohydrate Organisation (Florianópolis, Brazil)
2021/06/17 Unravelling the Bladder tumour microenvironment using the Flow cytometry toolbox. XVII Congress of the Iberian Society of Cytometry
Instituto Português de Oncologia do Porto, Francisco Gentil, E.P.E (Porto, Portugal)
2019/09/04 Exploring the influence of oxygen and glucose on the bladder cancer glycome by cellular O-glycome reporter amplification : insights for targeted therapeutics 13th International Meeting of the Portuguese Carbohydrate Group- GLUPOR13
Instituto de Investigação e Inovação em Saúde -I3s (Porto, Portugal)
2019/04/24 Bladder cancer Glycomics and Glycoproteomics identify GLUT1 and HOMER3 as top-ranked potentially targetable biomarkers Clinical Biochemistry and Metabolomics Seminars
Escola superior de Saúde (Porto, Portugal)
2019/03/27 Exploring the influence of oxygen and glucose on the bladder cancer glycome by cellular O-glycome reporter amplification: insights for targeted therapeutics. 8th Mass spectrometry and Carbohydrates Workshop
University of Aveiro (Aveiro, Portugal)
2018/07/14 Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension 29th International Carbohydrate Symposium- ICS2018
Faculty of Sciences of the University of Lisbon (Lisboa, Portugal)
2018/06/12 The sweet and sour of protein glycosylation in bladder cancer: setting milestones for clinical applications Biotechnology Seminars
School of Health Sciences - Polytechnic of Porto (Porto, Portugal)
2017/09/11 Hypoxia enhances the malignant nature of badder cancer cells and concomitantly antagonizes protein O-glycosylation extension 12ª reunião do Grupo de Glúcidos- GLUPOR12
Sociedade Portuguesa de Química (Aveiro, Portugal)
2015/05/13 Hypoxia induces bladder cancer cell invasion by antagonizing the extension of protein O-glycosylation IJUP- Encontro de Investigação Jovem na Universidade do Porto
Reitoria da Universidade do Porto (Porto, Portugal)
2015/03/20 Changes in protein glycosylation: biological implications for bladder cancer progression and dissemination Biochemistry in Health Seminars
School of Health Sciences - Polytechnic of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - 2025/09/01 Deciphering the Influence of CD276 glycocode in Colorectal Cancer Immunoregulation
Supervisor
 DEGREE IN BIOCHEMISTRY IN HEALTH (Master)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2024/02/04 - 2025/02/04 GlycoGuard: Glycophenotyping Early Signs of Gastric Cancer Towards Life Saving Interventions
Co-supervisor of Beatriz Marinho Santos
 LPCC- Norte-2024 (Other)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2024/01/01 - 2024/07/15 Tumor Microenvironment and Aberrant Glycosylation: A partnership driving immune escape.
Supervisor of Sara Francisca Ribeiro Freitas
 MEDICINAL BIOTECHNOLOGY (Degree)
School of Health Polytechnic Institute of Porto, Portugal
2022/09/12 - 2023/11/12 Functional glycoproteomics caracterization of gastric cancer cells expressing immature O-glycans
Supervisor of Martina Dourado Gonçalves
 Master Degree in Oncology (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/12 - 2023/11/12 Functional glycoproteomics characterization of gastric cancer cells expressing selectin ligands
Co-supervisor of Beatriz Marinho Santos
 Master Degree in Oncology (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/01 - 2022/12/31 glycoINSPIRER: PRE-CLINICAL VALIDATION OF A GLYCOCODE-INSPIRED VACCINE FOR BLADDER CANCER IMMUNOTHERAPY (under the LPCC-NRN 2022 grant funding)
Supervisor of Andreia Rafaela Linhares Miranda
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2021/09/01 - 2022/12/12 CD44 glycovaccine for Bladder Cancer: synthesis, pre-clinical validation and biotechnological solutions thereof
Co-supervisor of Eduardo da Silva Ferreira
 Master in Biochemistry (Master)
Universidade de Aveiro, Portugal
2020/09/18 - 2022/02/18 Decoding the Crosstalk Between Dendritic Cells and Bladder Cancer Associated Glycans: A Way to Identify Novel Immunotherapy Targets
Co-supervisor of Andreia Rafaela Linhares Miranda
 Master in Medicine and Molecular Oncology (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/02/01 - 2026/02/01 Organization of a series of 13 Workshops on Transferable skills for researchers, including topics on Public speaking and presentation techniques; Research integrity; Scientific writing; Grant writing (covering CV and motivational letters writing); Teamwork and collective intelligence / Leadership skills; Creativity for researchers (Science communication for broader audiences; creativity exercises); Scientific graphic design; Well-being and resilience (how to deal with & help others); Time management & life design. (2025/02/01 - 2026/02/01)
Workshop (Co-organisor)
 Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/11 - 2023/05/12 29th Porto Cancer Meeting- Glycosylation in tumour Biology and its clinical implications I The Cancer bittersweet portrait
Symposium
 29th Porto Cancer Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/07/10 - 2022/07/15 The International Carbohydrate Symposium is an important forum for researchers involved in all aspects of carbohydrates and a biennial event that was held in Brazil.
Symposium
 30th International Carbohydrate Symposium (ICS2022)
International Carbohydrate Organisation, Australia
2021/06/14 - 2021/06/18 XVII Congress of the Iberian Society of Cytometry
Congress
 XVII Congress of the Iberian Society of Cytometry
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2021/06/16 - 2021/06/16 CarboMet Webinar
Meeting
 CarboMet Meeting
2021/05/27 - 2021/05/29 4th METABOLISM & CANCER SYMPOSIUM
Symposium
 4th METABOLISM & CANCER SYMPOSIUM VIRTUAL MEETING
2021/05/20 - 2021/05/21 27th PORTO CANCER MEETING Stemness & Metastasis: Advances in Research and Clinical Translation
Meeting
 27th PORTO CANCER MEETING
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/05/03 - 2021/05/03 International summit to promote and to dynamize European research and innovation in heath collaborative networks to meet the European plan for cancer (Europe's Beating Cancer Plan).
Conference
 European Cancer Research Summit 2021
Porto Comprehensive Cancer Center (P.CCC), Portugal
2021/04/29 - 2021/04/29 Participation in the online cycle of conferences in glycosciences promoted by the Grupo Especializado de Hidratos de Carbono de la Real Sociedad Española de Química.
Conference
 Conferencias en Glicociencias
Grupo Especializado de Hidratos de Carbono (RSEQ) de la Real Sociedad Española de Química, Spain
2016/03/10 - 2016/03/10 Instructor at the theoretical and practical course of molecular biology applied to oncology.
Conference
 1st Precision Oncology Meeting
Universidade Fernando Pessoa, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/07/07 Hematological parameters as prognostic biomarkers in esophageal and gastric cancer.
(Thesis) Main arguer
 Paulo Sérgio do Valle (Master)
Universidade Fernando Pessoa Faculdade de Ciências da Saúde, Portugal

Association member

Society Organization name Role
2024/11/18 - Current COST Action CA21135 IMMUNO-model member
2023/10/01 - Current Raquel Seruca Immuno-Oncology Club member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/02/10 - 2019/06/01 Integrated Laboratory Practice II (Licenciatura) Polytechnic Institute of Porto - School of Health, Portugal
2019/03/01 - 2019/04/30 Molecular and Celular Therapy Pathological Anatomy Master Degree (Mestrado) School of Heath Polytechnic Institute of Porto, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020/11/17 - Current Invited reviewer of the Journal of Molecular Medicine.
Evaluator
2022/09/05 - 2022/09/09 Elsevier book proposal reviewer for the working title "Colorectal Cancer: Disease, Diagnosis and Drug Delivery Approaches"
Evaluator
 Elsevier Inc, United States Elsevier Inc
2021/07/23 - 2021/07/30 Invited International journal of molecular sciences reviewer
Evaluator
2021/06/01 - 2021/06/01 Invited Cells journal reviewer
Evaluator
2021/02/20 - 2021/02/27 Invited Cancers journal reviewer
Evaluator
2021/02/05 - 2021/02/15 Invited Frontiers Immunology journal reviewer
Evaluator
2021/01/20 - 2021/02/11 Invited NWO Open Competition Domain Science M grants reviewer
Evaluator
 Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Netherlands
2021/01/04 - 2021/01/10 Invited Frontiers Cell and Developmental Biology journal reviewer
Evaluator
2020/11/22 - 2020/11/30 Elsevier book proposal reviewer for the book series "High throughput technologies in disease diagnostics and therapeutics"
Evaluator
 Elsevier Ltd, United Kingdom Elsevier Ltd
2020/04/18 - 2020/04/22 Invited Journal of Oncology journal reviewer
Evaluator
 Hindawi Publishing Corp
2019/11/20 - 2019/11/29 Elsevier proposal reviewer for the book series "Precision Medicine for the Management of Metastatic Cancers" Elsevier Ltd, United Kingdom

Journal scientific committee

Journal title (ISSN) Publisher
2023/02/10 - Current The Role of Glycosylation on EMT and Mucins in Cancer Development, Diagnostics, and Therapeutics Frontiers in Molecular Biosciences
2021/11/21 - Current Tumor-Associated Glycans and their Receptors on Immune Cells: Sweet-Talking the Security Guards in the Tumor Microenvironment Frontiers in Molecular Biosciences

Mentoring / Tutoring

Topic Student name
2022/02/14 - 2022/06/03 Laboratory and clinical practice training Martina Dourado Gonçalves
2022/02/14 - 2022/06/03 Laboratory and clinical practice training Beatriz Marinho Santos

Scientific expedition

Activity description Institution / Organization
2021/11/01 - 2021/11/10 Participated in the EPIC-XS project "Phosphoproteomics of Hypoxic and Glucose-Deprived Bladder Cancer Cells: The Missing Link Towards Systems Oncology." I developed and optimized advanced proteomics and phosphoproteomics workflows for the analysis of bladder cancer cell models under hypoxic and glucose-deprived conditions at the Netherlands Proteomics Center. This experience enhanced my technical expertise in mass spectrometry-based proteomics and contributed to the project’s goal of elucidating signaling pathways relevant to systems oncology. Netherlands Proteomics Centre, Netherlands
Distinctions

Other distinction

2023 Individual Call to Scientific Employment Stimulus - 6th Edition
Fundação para a Ciência e a Tecnologia, Portugal
2022 Call for R&D Projects in All Scientific Domains - 2022
Fundação para a Ciência e a Tecnologia, Portugal
2015 PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2014 Merit scholarship and diploma for exceptional academic performance
Universidade do Porto, Portugal