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E. Mendes graduated in Pharmaceutical Sciences at the University of Lisbon (ULisboa) in 1986. In 1989, she finished a Master's Degree in Organic Technological Chemistry at Universidade Nova de Lisboa (Terpenoids from Salvia candelabrum). In 1998, E. Mendes concluded a PhD in the field of medicinal Chemistry (Synthesis and Evaluation of Potential Prodrugs of Carboxylic Acids) at the ULisboa. Since 1998, she is an assistant professor at the Faculty of Pharmacy of ULisboa (FFUL), working in Medicinal Chemistry, particularly, in prodrugs. Mendes¿ research has focused on the development of novel chemical delivery systems, including a strategy to increase the selectivity of several hybrid molecules with potential application in malignant melanoma. She was also involved in a project to develop potential candidates for neurodegenerative diseases with emphasis on exploring the enzymatic inhibitory activities of some classes of compounds. Another line of research in which she has been working is the development of compounds to target nucleic acids G-quadruplex structures and repress oncogene expression in cancer cells. She has been involved in research projects with national and international scientists. Currently, E. Mendes research is focused on the design, synthesis, structure-activity studies, and development and implementation of analytical procedures and methods for the chemical studies.
Identification

Personal identification

Full name
Maria Eduarda Romãozinho de Almeida Esteves Mendes

Citation names

  • Eduarda Mendes

Author identifiers

Ciência ID
3617-10D1-D66E
ORCID iD
0000-0002-7926-8821
Education
Degree Classification
1998
Concluded
Eduarda Mendes (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
""Development of Potential Prodrugs of Carboxylic Acids" (TESE/DISSERTAÇÃO)" (THESIS/DISSERTATION)
Muito Bom com Distinção e Louvor
1989
Concluded
Master in Technological Organic Chemistry (Mestrado)
Universidade Nova de Lisboa, Portugal
""Diterpenoids from Salvia candelabrum"" (THESIS/DISSERTATION)
Muito Bom
1986
Concluded
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"." (THESIS/DISSERTATION)
15 valores
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
1998/03/03 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2023/01/02 - 2024/07/01 Inquiring the druggability of DNAG4-helicase interactions with small molecules
2022.06099.PTDC
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Nanoformulated Hybrid Molecules for Targeting Melanoma Metastasis
PTDC/MED-QUI/31721/2017
Fundação para a Ciência e a Tecnologia
Ongoing
2013/06/24 - 2014/12/25 Exploring a new approach to the KRAS oncogene as a therapeutic target
EXPL/QEQ-MED/0502/2012
Fundação para a Ciência e a Tecnologia
Concluded
2007/08/01 - 2011/07/31 Design, synthesis and biological evaluation of multifunctional compounds for Alzheimer's disease
PTDC/SAU-NEU/64151/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Eduarda Mendes; M. Jesus Perry; Ana Paula Francisco. "The synthetic utility of triazenes in heterocycle synthesis". In Heterocyclic Targets in Advanced Organic Synthesis, 125-144. India, 2011.
    Published
  2. Ana Paula Francisco; Maria de Jesus Perry; Rui Moreira; Eduarda Mendes. "Alkylating Agents". In Anticancer Therapeutics, 133-158. United Kingdom, 2008.
    Published • 10.1002/9780470697047.ch9
Journal article
  1. Maria Eduarda Mendes. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics (2023):
    https://doi.org/10.1016/j.ijpharm.2023.123011
  2. Maria Eduarda Mendes. "G-quadruplexes in c-MYC Promoter as Targets for Cancer Therapy". Biomedicines (2023):
    DOI: 10.3390/biomedicines11030969
  3. "Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands". Bioorganic & Medicinal Chemistry Letters 72 (2022): 128862-128862. http://dx.doi.org/10.1016/j.bmcl.2022.128862.
    10.1016/j.bmcl.2022.128862
  4. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals 2022, 15, 300. (2022):
    doi.org/10.3390/ph15030300
  5. "Plant Terpenoids as Hit Compounds against Trypanosomiasis". Pharmaceuticals 2022, 15, 340. (2022):
    https://doi.org/ 10.3390/ph15030340
  6. Branco, Vasco; Carvalho, Luís; Barboza, Cássia; Mendes, Maria Eduarda; Cavaco, Afonso; Carvalho, Cristina. "Selenium and Redox Enzyme Activity in Pregnant Women Exposed to Methylmercury". (2022): http://hdl.handle.net/10451/58901.
    10.3390/antiox11112291
  7. Maria Mendes; Duarte, N. "Mid-Infrared Spectroscopy as a Valuable Tool to Tackle Food Analysis: A Literature Review on Coffee, Dairies, Honey, Olive Oil and Wine". Foods (2021): https://www.mdpi.com/2304-8158/10/2/477.
    10.3390/foods10020477
  8. Eduarda Mendes. "Sulfur Analogues of Tyrosine in the Development of Triazene Hybrid Compounds: A New Strategy against Melanoma". ACS Med. Chem. Lett. (2021):
    Published • doi.org/10.1021/acsmedchemlett.1c00252
  9. Eduarda Mendes. "New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study". Pharmaceuticals 14 7 (2021): 669.
    Open access • Published • doi.org/10.3390/ph14070669
  10. Zwergel, Clemens; Fioravanti, Rossella; Stazi, Giulia; Sarno, Federica; Battistelli, Cecilia; Romanelli, Annalisa; Nebbioso, Angela; et al. "Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation". Cancers 12 2 (2020): 447. http://dx.doi.org/10.3390/cancers12020447.
    10.3390/cancers12020447
  11. Rajat Ghosh; Jorge B. Vitor; Eduarda Mendes; Alexandra Paulo; Pratap Chandra Acharya. "Stereoselective synthesis of spirooxindole derivatives using one-pot multicomponent cycloaddition reaction and evaluation of their antiproliferative efficacy". ACS Omega 5 (42) (2020): 27332-27343.
    Open access • Published
  12. Ghosh, Rajat; Vítor, Jorge M. B.; Mendes, Maria Eduarda; Paulo, Alexandra; Acharya, Pratap Chandra. "Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy". (2020): http://hdl.handle.net/10451/58873.
    10.1021/acsomega.0c03675
  13. Silva, Daniel; Mendes, Eduarda; Summers, Eleanor J.; Neca, Ana; Jacinto, Ana C.; Reis, Telma; Agostinho, Paula; et al. "Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents". Drug Development Research (2019): http://dx.doi.org/10.1002/ddr.21594.
    10.1002/ddr.21594
  14. Francisco, Ana P.; Mendes, Eduarda; Santos, Ana R.; Perry, Maria J.. "Anticancer Triazenes: from Bioprecursors to Hybrid Molecules". (2019):
    10.2174/1381612825666190617155749
  15. Mendes, Eduarda; Cadoni, Enrico; Carneiro, Filipa; Afonso, Marta B.; Brito, Hugo; Lavrado, João; dos Santos, Daniel J. V. A.; et al. "Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells". ChemMedChem 14 14 (2019): 1325-1328. http://dx.doi.org/10.1002/cmdc.201900243.
    10.1002/cmdc.201900243
  16. Sousa, A.; Santos, F.; Gaspar, M.M.; Calado, S.; Pereira, J.D.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "The selective cytotoxicity of new triazene compounds to human melanoma cells". Bioorganic and Medicinal Chemistry 25 15 (2017): 3900-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020296185&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.049
  17. Eduarda Mendes; Susana Calado; Carla Eleutério; Maria de Jesus Rocha; Ana Paula Francisco; Maria Manuela Gaspar. "Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma". J Nanosci Adv Tech 1 4 (2016): 1-9.
    Published • 10.24218/jnat.2016.16
  18. Brito, H.; Martins, A.C.; Lavrado, J.; Mendes, E.; Francisco, A.P.; Santos, S.A.; Ohnmacht, S.A.; et al. "Targeting KRAS oncogene in colon cancer cells with 7-carboxylate Indolo[3,2-b] quinoline tri-alkylamine derivatives". PLoS ONE 10 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84934910595&partnerID=MN8TOARS.
    10.1371/journal.pone.0126891
  19. Mendes, E.; Perry, M.D.J.; Francisco, A.P.. "Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications". Expert Opinion on Drug Discovery 9 5 (2014): 533-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899116068&partnerID=MN8TOARS.
    10.1517/17460441.2014.907789
  20. Juárez-Jiménez, J.; Mendes, E.; Galdeano, C.; Martins, C.; Silva, D.B.; Marco-Contelles, J.; Do Carmo Carreiras, M.; Luque, F.J.; Ramsay, R.R.. "Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies". Biochimica et Biophysica Acta - Proteins and Proteomics 1844 2 (2014): 389-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890495975&partnerID=MN8TOARS.
    10.1016/j.bbapap.2013.11.003
  21. Carmo Carreiras, M.; Mendes, E.; Jesus Perry, M.; Francisco, A.P.; Marco-Contelles, J.. "The multifactorial nature of Alzheimer's disease for developing potential therapeutics". Current Topics in Medicinal Chemistry 13 15 (2013): 1745-1770. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887972850&partnerID=MN8TOARS.
  22. Silva, D.; Chioua, M.; Samadi, A.; Agostinho, P.; Garção, P.; Lajarín-Cuesta, R.; De Los Ríos, C.; et al. "Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: Effect against amyloid-ß-induced neurotoxicity". ACS Chemical Neuroscience 4 4 (2013): 547-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529529&partnerID=MN8TOARS.
    10.1021/cn300178k
  23. Monteiro, A.S.; Almeida, J.; Cabral, G.; Severino, P.; Videira, P.A.; Sousa, A.; Nunes, R.; et al. "Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines". European Journal of Medicinal Chemistry 70 (2013): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885368654&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.040
  24. Capucha, V.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "Development of triazene prodrugs for ADEPT strategy: New insights into drug delivery system based on carboxypeptidase G2 activation". Bioorganic and Medicinal Chemistry Letters 22 22 (2012): 6903-6908. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867847410&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.09.029
  25. Silva, D.; Chioua, M.; Samadi, A.; Carmo Carreiras, M.; Jimeno, M.-L.; Mendes, E.; Ríos, C.D.L.; et al. "Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives". European Journal of Medicinal Chemistry 46 9 (2011): 4676-4681. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052951494&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.05.068
  26. Perry, M.J.; Mendes, E.; Simplício, A.L.; Coelho, A.; Soares, R.V.; Iley, J.; Moreira, R.; Francisco, A.P.. "Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design". European Journal of Medicinal Chemistry 44 8 (2009): 3228-3234. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349149632&partnerID=MN8TOARS.
    10.1016/j.ejmech.2009.03.025
  27. Ribeiro, L.; Silva, N.; Iley, J.; Rautio, J.; Järvinen, T.; Mota-Filipe, H.; Moreira, R.; Mendes, E.. "Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: Suppressing the rearrangement pathway in aqueous media". Archiv der Pharmazie 340 1 (2007): 32-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846547138&partnerID=MN8TOARS.
    10.1002/ardp.200600145
  28. Mendes, E.; Furtado, T.; Neres, J.; Iley, J.; Jarvinen, T.; Rautio, J.; Moreira, R.. "Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents". Bioorganic and Medicinal Chemistry 10 3 (2002): 809-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036158330&partnerID=MN8TOARS.
    10.1016/S0968-0896(01)00336-4
  29. Iley, J.; Mendes, E.; Moreira, R.; Souza, S.. "Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates". European Journal of Pharmaceutical Sciences 9 2 (1999): 201-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033460252&partnerID=MN8TOARS.
    10.1016/S0928-0987(99)00057-3
  30. Iley, J.; Moreira, R.; Calheiros, T.; Mendes, E.. "Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl-ester prodrugs of carboxylic acid agents". Pharmaceutical Research 14 11 (1997): 1634-1639. http://www.scopus.com/inward/record.url?eid=2-s2.0-6844261184&partnerID=MN8TOARS.
    10.1023/A:1012146905833
  31. Moreira, R.; Calheiros, T.; Cabrita, J.; Mendes, E.; Pimentel, M.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: Chemical hydrolysis and anti-bacterial activity". Pharmaceutical Research 13 1 (1996): 70-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029865020&partnerID=MN8TOARS.
    10.1023/A:1016077200460
  32. Moreira, R.; Mendes, E.; Calheiros, T.; Bacelo, M.J.; Iley, J.. "A new direct synthesis of tertiary N-acyloxymethylamide prodrugs of carboxylic acid drugs". Tetrahedron Letters 35 38 (1994): 7107-7110. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027971217&partnerID=MN8TOARS.
  33. Mendes, E.; Simoes, F.; De La Torre, M.C.; Rodriguez, B.. "Terpenoids from Salvia sclareoides". Fitoterapia 64 1 (1993): http://www.scopus.com/inward/record.url?eid=2-s2.0-0027417780&partnerID=MN8TOARS.
  34. Mendes, E.; Marco, J.L.; Rodríguez, B.; Jimeno, M.L.; Lobo, A.M.; Prabhakar, S.. "Diterpenoids from Salvia candelabrum". Phytochemistry 28 6 (1989): 1685-1690. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001584631&partnerID=MN8TOARS.
Newspaper article
  1. Maria Eduarda Mendes. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management", 2023, https://doi.org/10.1016/j.biopha.2022.114021.
    DOI: 10.1016/j.biopha.2022.114021
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/10 - Current Novos derivados de triazenos direcionados para o combate do melanoma metastático/ "Novel targeted triazene derivatives against metastatic melanoma"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
2020 - 2021 Síntese e avaliação biológica de novos compostos antitumorais derivados de triazenos´/ "Synthesis and biological evaluation of new antitumor triazenes derivatives"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020 Desenvolvimento de moléculas híbridas para o tratamento do melanoma maligno metastático/ "Development of hybrid molecules for the treatment of metastatic malignant melanoma"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Síntese e avaliação biológica de potenciais inibidores da acetilcolinesterase e monoamina oxidase para a doença de Alzheimer/ "Synthesis and biological evaluation of potential acetylcholinesterase and monoamine oxidase inhibitors for Alzheimer's disease"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Avaliação quantitativa de metais contaminantes em diferentes tipos de cerveja comercializada em Portugal/ "Quantitative assessment of contaminating metals in different types of beer marketed in Portugal"
Co-supervisor
Mestrado em Controlo de Qualidade e Toxicologia dos Alimentos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Avaliação biológica de inibidores de monoamina oxidase A e B: síntese de análogos promissores/ "Biological evaluation of monoamine oxidase A and B inhibitors: synthesis of promising analogs"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Estudo comparativo do teor em metais contaminantes em amostras de chás provenientes de agricultura tradicional e biológica/ "Comparative study of the content of contaminating metals in tea samples from traditional and organic farming"
Supervisor
Mestrado em Controlo de Qualidade e Toxicologia dos Alimentos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012 Síntese e avaliação biológica de inibidores da monoamino oxidase para estratégias neuroprotetoras/ "Synthesis and biological evaluation of monoamine oxidase inhibitors for neuroprotective strategies"
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012 Síntese e estudo cinético de potenciais pró-fármacos para aplicação em MDEPT/ "Synthesis and kinetic study of potential prodrugs for application in MDEPT"
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2011 Estudo do Efeito Anti-tumoral de pró-fármacos de triazenos em linhas celulares de melanoma/ "Study of the anti-tumor effect of triazene prodrugs in melanoma cell lines"
Co-supervisor
Master in Clinical Analysis (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2010/05 Análise quantitativa de metais contaminantes em adoçantes comercializados em Portugal/ " Quantitative analysis of contaminating metals in sweeteners marketed in Portugal"
Co-supervisor
Mestrado em Controlo de Qualidade e Toxicologia dos Alimentos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2009/10 Pró-Fármacos de Triazenos Antitumorais para estudos ADEPT e MDEPT/ "Anti-tumor Triazene Prodrugs for ADEPT and MDEPT studies"
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal