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My research focuses on the eco-evolutionary mechanisms that influence genetic diversity and its variations at the genome scale and in space. It spans micro- and macro-evolutionary timescales, starting with intra-population mechanisms and extending to the study of divergence leading to speciation, and finally to molecular evolution between isolated species. To study these different levels, I use concepts and analysis methods from population genetics and apply them to polymorphism data produced using genome sequencing technologies. My study models are mainly fish and marine invertebrates. Although essentially fundamental, my research has applications in aquaculture genetic programmes and in the conservation and management of natural populations.
Identification

Personal identification

Full name
Pierre-Alexandre Gagnaire

Citation names

  • Gagnaire, Pierre-Alexandre

Author identifiers

Ciência ID
3612-AEB3-3244
ORCID iD
0000-0002-1908-3235
Google Scholar ID
orGqHhAAAAAJ&hl

Websites

  • https://cv.archives-ouvertes.fr/pierre-alexandre-gagnaire (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Evolutionary Biology

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2009
Concluded
Population genetics (Doctor of Philosophy)
Université de Montpellier, France
2004 - 2006
Concluded
Cellular and Molecular Biology, Oncology (Master)
École Normale Supérieure de Lyon, France
2002 - 2003
Concluded
Molecular and Cellular Biology (Licence)
École Normale Supérieure de Lyon, France
Affiliation

Science

Category
Host institution
Employer
2013 - Current Principal Investigator (Research) Université de Montpellier, France
2011 - 2013 Principal Investigator (Research) Institut des sciences de l'évolution de Montpellier, France
2010 - 2011 Postdoc (Research) Université Laval, Canada
2009 - 2010 Postdoc (Research) Université Laval, Canada
Projects

Grant

Designation Funders
2024/10/01 - 2028/09/30 Improving recent demographic inferences for marine conservation with genome-wide co-ancestry
ANR-24-CE02-4266-01
Principal investigator
CNRS Délégation Occitanie Est, France
Agence nationale de la recherche
Ongoing

Other

Designation Funders
2018/01/03 - 2021/01/03 Comparative Genomics of Divergence for linking speciation to species life-history traits – CoGeDiv
Principal investigator
Agence nationale de la recherche, France
Ongoing
2013/01/03 - 2014/01/03 ArchiGen
Principal investigator
Concluded
2011/01/03 - 2014/01/03 Labrad-Seq
Principal investigator
Agence nationale de la recherche, France
Concluded
Outputs

Publications

Journal article
  1. Meyer, Laura; Barry, Pierre; Riquet, Florentine; Foote, Andrew; Der Sarkissian, Clio; Cunha, Regina L.; Arbiol, Christine; et al. "Divergence and gene flow history at two large chromosomal inversions underlying ecotype differentiation in the long-snouted seahorse". (2024): http://hdl.handle.net/10400.1/20411.
    10.1111/mec.17277
  2. Jade Castel; Stéphane Hourdez; Florence Pradillon; Claire Daguin-Thiebaut; Marion Ballenghien; Stéphanie Ruault; Erwan Corre; et al. "Inter-Specific Genetic Exchange Despite Strong Divergence in Deep-Sea Hydrothermal Vent Gastropods of the Genus Alviniconcha". Genes (2022): https://www.mdpi.com/2073-4425/13/6/985.
    10.3390/genes13060985
  3. Carine Rey; Audrey Darnaude; Franck Ferraton; Bruno Guinand; François Bonhomme; Nicolas Bierne; Pierre-Alexandre Gagnaire. "Within-Generation Polygenic Selection Shapes Fitness-Related Traits across Environments in Juvenile Sea Bream". Genes (2020): https://www.mdpi.com/2073-4425/11/4/398.
    10.3390/genes11040398
  4. Sylvie Lapegue; Serge Heurtebise; Florence Cornette; Erwan Guichoux; Pierre-Alexandre Gagnaire. "Genetic Characterization of Cupped Oyster Resources in Europe Using Informative Single Nucleotide Polymorphism (SNP) Panels". Genes (2020): https://www.mdpi.com/2073-4425/11/4/451.
    10.3390/genes11040451
  5. Leitwein, Maeva; Duranton, Maud; Rougemont, Quentin; Gagnaire, Pierre-Alexandre; Bernatchez, Louis. "Using Haplotype Information for Conservation Genomics". Trends in Ecology & Evolution 35 3 (2020): 245-258. http://dx.doi.org/10.1016/j.tree.2019.10.012.
    10.1016/j.tree.2019.10.012
  6. Leitwein, Maeva; Cayuela, Hugo; Ferchaud, Anne-Laure; Normandeau, Éric; Gagnaire, Pierre-Alexandre; Bernatchez, Louis. "The role of recombination on genome-wide patterns of local ancestry exemplified by supplemented brook charr populations". Molecular Ecology 28 21 (2019): 4755-4769. http://dx.doi.org/10.1111/mec.15256.
    10.1111/mec.15256
  7. Rougeux, Clément; Gagnaire, Pierre-Alexandre; Praebel, Kim; Seehausen, Ole; Bernatchez, Louis. "Polygenic selection drives the evolution of convergent transcriptomic landscapes across continents within a Nearctic sister species complex". Molecular Ecology 28 19 (2019): 4388-4403. http://dx.doi.org/10.1111/mec.15226.
    10.1111/mec.15226
  8. Saint-Pé, Keoni; Leitwein, Maeva; Tissot, Laurence; Poulet, Nicolas; Guinand, Bruno; Berrebi, Patrick; Marselli, Geoffrey; et al. "Development of a large SNPs resource and a low-density SNP array for brown trout (Salmo trutta) population genetics". BMC Genomics 20 1 (2019): http://dx.doi.org/10.1186/s12864-019-5958-9.
    10.1186/s12864-019-5958-9
  9. Duranton, Maud; Bonhomme, François; Gagnaire, Pierre-Alexandre. "The spatial scale of dispersal revealed by admixture tracts". Evolutionary Applications 12 9 (2019): 1743-1756. http://dx.doi.org/10.1111/eva.12829.
    10.1111/eva.12829
  10. Vandeputte, M.; Gagnaire, P.-A.; Allal, F.. "The European sea bass: a key marine fish model in the wild and in aquaculture". Animal Genetics 50 3 (2019): 195-206. http://dx.doi.org/10.1111/age.12779.
    10.1111/age.12779
  11. Riquet, Florentine; Liautard-Haag, Cathy; Woodall, Lucy; Bouza, Carmen; Louisy, Patrick; Hamer, Bojan; Otero-Ferrer, Francisco; et al. "Parallel pattern of differentiation at a genomic island shared between clinal and mosaic hybrid zones in a complex of cryptic seahorse lineages". Evolution 73 4 (2019): 817-835. http://dx.doi.org/10.1111/evo.13696.
    10.1111/evo.13696
  12. Faggion, Sara; Vandeputte, Marc; Chatain, Béatrice; Gagnaire, Pierre-Alexandre; Allal, François. "Population-specific variations of the genetic architecture of sex determination in wild European sea bass Dicentrarchus labrax L.". Heredity 122 5 (2018): 612-621. http://dx.doi.org/10.1038/s41437-018-0157-z.
    10.1038/s41437-018-0157-z
  13. Gagnaire, Pierre-Alexandre; Lamy, Jean-Baptiste; Cornette, Florence; Heurtebise, Serge; Dégremont, Lionel; Flahauw, Emilie; Boudry, Pierre; Bierne, Nicolas; Lapègue, Sylvie. "Analysis of Genome-Wide Differentiation between Native and Introduced Populations of the Cupped Oysters Crassostrea gigas and Crassostrea angulata". Genome Biology and Evolution 10 9 (2018): 2518-2534. http://dx.doi.org/10.1093/gbe/evy194.
    10.1093/gbe/evy194
  14. Leitwein, Maeva; Gagnaire, Pierre-Alexandre; Desmarais, Erick; Berrebi, Patrick; Guinand, Bruno. "Genomic consequences of a recent three-way admixture in supplemented wild brown trout populations revealed by local ancestry tracts". Molecular Ecology 27 17 (2018): 3466-3483. http://dx.doi.org/10.1111/mec.14816.
    10.1111/mec.14816
  15. Fraïsse, Christelle; Roux, Camille; Gagnaire, Pierre-Alexandre; Romiguier, Jonathan; Faivre, Nicolas; Welch, John J.; Bierne, Nicolas. "The divergence history of European blue mussel species reconstructed from Approximate Bayesian Computation: the effects of sequencing techniques and sampling strategies". PeerJ 6 (2018): e5198. http://dx.doi.org/10.7717/peerj.5198.
    10.7717/peerj.5198
  16. Duranton, Maud; Allal, François; Fraïsse, Christelle; Bierne, Nicolas; Bonhomme, François; Gagnaire, Pierre-Alexandre. "The origin and remolding of genomic islands of differentiation in the European sea bass". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-04963-6.
    10.1038/s41467-018-04963-6
  17. Souissi, Ahmed; Bonhomme, François; Manchado, Manuel; Bahri-Sfar, Lilia; Gagnaire, Pierre-Alexandre. "Genomic and geographic footprints of differential introgression between two divergent fish species (Solea spp.)". Heredity 121 6 (2018): 579-593. http://dx.doi.org/10.1038/s41437-018-0079-9.
    10.1038/s41437-018-0079-9
  18. Babin, Charles; Gagnaire, Pierre-Alexandre; Pavey, Scott A; Bernatchez, Louis. "RAD-Seq Reveals Patterns of Additive Polygenic Variation Caused by Spatially-Varying Selection in the American Eel (Anguilla rostrata)". Genome Biology and Evolution 9 11 (2017): 2974-2986. http://dx.doi.org/10.1093/gbe/evx226.
    10.1093/gbe/evx226
  19. Rougeux, Clément; Bernatchez, Louis; Gagnaire, Pierre-Alexandre. "Modeling the Multiple Facets of Speciation-with-Gene-Flow toward Inferring the Divergence History of Lake Whitefish Species Pairs (Coregonus clupeaformis)". Genome Biology and Evolution 9 8 (2017): 2057-2074. http://dx.doi.org/10.1093/gbe/evx150.
    10.1093/gbe/evx150
  20. Leitwein, Maeva; Guinand, Bruno; Pouzadoux, Juliette; Desmarais, Erick; Berrebi, Patrick; Gagnaire, Pierre-Alexandre. "A Dense Brown Trout (Salmo trutta) Linkage Map Reveals Recent Chromosomal Rearrangements in theSalmoGenus and the Impact of Selection on Linked Neutral Diversity". G3: Genes|Genomes|Genetics 7 4 (2017): 1365-1376. http://dx.doi.org/10.1534/g3.116.038497.
    10.1534/g3.116.038497
  21. Souissi, Ahmed; Gagnaire, Pierre-Alexandre; Bonhomme, François; Bahri-Sfar, Lilia. "Introgressive hybridization and morphological transgression in the contact zone between two MediterraneanSoleaspecies". Ecology and Evolution 7 5 (2017): 1394-1402. http://dx.doi.org/10.1002/ece3.2533.
    10.1002/ece3.2533
  22. Guinand, B; Chauvel, C; Lechene, M; Tournois, J; Tsigenopoulos, CS; Darnaude, AM; McKenzie, DJ; Gagnaire, PA. "Candidate gene variation in gilthead sea bream reveals complex spatiotemporal selection patterns between marine and lagoon habitats". Marine Ecology Progress Series 558 (2016): 115-127. http://dx.doi.org/10.3354/meps11851.
    10.3354/meps11851
  23. Rougemont, Quentin; Gagnaire, Pierre-Alexandre; Perrier, Charles; Genthon, Clémence; Besnard, Anne-Laure; Launey, Sophie; Evanno, Guillaume. "Inferring the demographic history underlying parallel genomic divergence among pairs of parasitic and nonparasitic lamprey ecotypes". Molecular Ecology 26 1 (2016): 142-162. http://dx.doi.org/10.1111/mec.13664.
    10.1111/mec.13664
  24. Le Moan, A.; Gagnaire, P.-A.; Bonhomme, F.. "Parallel genetic divergence among coastal-marine ecotype pairs of European anchovy explained by differential introgression after secondary contact". Molecular Ecology 25 13 (2016): 3187-3202. http://dx.doi.org/10.1111/mec.13627.
    10.1111/mec.13627
  25. Szulkin, M.; Gagnaire, P.-A.; Bierne, N.; Charmantier, A.. "Population genomic footprints of fine-scale differentiation between habitats in Mediterranean blue tits". Molecular Ecology 25 2 (2016): 542-558. http://dx.doi.org/10.1111/mec.13486.
    10.1111/mec.13486
  26. Miller, Michael J.; Feunteun, Eric; Aoyama, Jun; Watanabe, Shun; Kuroki, Mari; Lecomte-Finiger, Raymonde; Minegishi, Yuki; et al. "Biodiversity and distribution of leptocephali west of the Mascarene Plateau in the southwestern Indian Ocean". Progress in Oceanography 137 (2015): 84-102. http://dx.doi.org/10.1016/j.pocean.2015.05.026.
    10.1016/j.pocean.2015.05.026
  27. Gagnaire, Pierre-Alexandre; Broquet, Thomas; Aurelle, Didier; Viard, Frédérique; Souissi, Ahmed; Bonhomme, François; Arnaud-Haond, Sophie; Bierne, Nicolas. "Using neutral, selected, and hitchhiker loci to assess connectivity of marine populations in the genomic era". Evolutionary Applications 8 8 (2015): 769-786. http://dx.doi.org/10.1111/eva.12288.
    10.1111/eva.12288
  28. Tine, Mbaye; Kuhl, Heiner; Gagnaire, Pierre-Alexandre; Louro, Bruno; Desmarais, Erick; Martins, Rute S.T.; Hecht, Jochen; et al. "European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms6770.
    10.1038/ncomms6770
  29. Sevellec, M.; Pavey, S. A.; Boutin, S.; Filteau, M.; Derome, N.; Bernatchez, L.. "Microbiome investigation in the ecological speciation context of lake whitefish (Coregonus clupeaformis) using next-generation sequencing". Journal of Evolutionary Biology 27 6 (2014): 1029-1046. http://dx.doi.org/10.1111/jeb.12374.
    10.1111/jeb.12374
  30. Ulrik, Malene G; Pujolar, José; Ferchaud, Anne-Laure; Jacobsen, Magnus W; Als, Thomas D; Gagnaire, Pierre; Frydenberg, Jane; et al. "Do North Atlantic eels show parallel patterns of spatially varying selection?". BMC Evolutionary Biology 14 1 (2014): 138. http://dx.doi.org/10.1186/1471-2148-14-138.
    10.1186/1471-2148-14-138
  31. Tine, Mbaye; Kuhl, Heiner; Gagnaire, Pierre-Alexandre; Louro, Bruno; Desmarais, Erick; Martins, Rute S. T.; Hecht, Jochen; et al. "European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation". (2014): http://hdl.handle.net/10400.1/11216.
    10.1038/ncomms6770
  32. Gagnaire, Pierre-Alexandre; Pavey, Scott A.; Normandeau, Eric; Bernatchez, Louis. "THE GENETIC ARCHITECTURE OF REPRODUCTIVE ISOLATION DURING SPECIATION-WITH-GENE-FLOW IN LAKE WHITEFISH SPECIES PAIRS ASSESSED BY RAD SEQUENCING". Evolution 67 9 (2013): 2483-2497. http://dx.doi.org/10.1111/evo.12075.
    10.1111/evo.12075
  33. Bierne, Nicolas; Gagnaire, Pierre-Alexandre; David, Patrice. "The geography of introgression in a patchy environment and the thorn in the side of ecological speciation". Current Zoology 59 1 (2013): 72-86. http://dx.doi.org/10.1093/czoolo/59.1.72.
    10.1093/czoolo/59.1.72
  34. Côté, Caroline L.; Gagnaire, Pierre-Alexandre; Bourret, Vincent; Verreault, Guy; Castonguay, Martin; Bernatchez, Louis. "Population genetics of the American eel (Anguilla rostrata):FST = 0 and North Atlantic Oscillation effects on demographic fluctuations of a panmictic species". Molecular Ecology 22 7 (2012): 1763-1776. http://dx.doi.org/10.1111/mec.12142.
    10.1111/mec.12142
  35. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Pavey, Scott A.; Bernatchez, Louis. "Mapping phenotypic, expression and transmission ratio distortion QTL using RAD markers in the Lake Whitefish(Coregonus clupeaformis)". Molecular Ecology 22 11 (2012): 3036-3048. http://dx.doi.org/10.1111/mec.12127.
    10.1111/mec.12127
  36. Chaoui, Lamya; Gagnaire, Pierre-Alexandre; Guinand, Bruno; Quignard, Jean-Pierre; Tsigenopoulos, Costas; Kara, M. Hichem; Bonhomme, François. "Microsatellite length variation in candidate genes correlates with habitat in the gilthead sea breamSparus aurata". Molecular Ecology 21 22 (2012): 5497-5511. http://dx.doi.org/10.1111/mec.12062.
    10.1111/mec.12062
  37. Laflamme, Simon; Côté, Caroline; Gagnaire, Pierre-Alexandre; Castonguay, Martin; Bernatchez, Louis. "RNA/DNA ratios in American glass eels (Anguilla rostrata): evidence for latitudinal variation in physiological status and constraints to oceanic migration?". Ecology and Evolution 2 5 (2012): 875-884. http://dx.doi.org/10.1002/ece3.212.
    10.1002/ece3.212
  38. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Bernatchez, Louis. "Comparative Genomics Reveals Adaptive Protein Evolution and a Possible Cytonuclear Incompatibility between European and American Eels". Molecular Biology and Evolution 29 10 (2012): 2909-2919. http://dx.doi.org/10.1093/molbev/mss076.
    10.1093/molbev/mss076
  39. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Côté, Caroline; Møller Hansen, Michael; Bernatchez, Louis. "The Genetic Consequences of Spatially Varying Selection in the Panmictic American Eel (Anguilla rostrata)". Genetics 190 2 (2011): 725-736. http://dx.doi.org/10.1534/genetics.111.134825.
    10.1534/genetics.111.134825
  40. Minegishi, Yuki; Gagnaire, Pierre-Alexandre; Aoyama, Jun; Bosc, Pierre; Feunteun, Eric; Tsukamoto, Katsumi; Berrebi, Patrick. "Present and past genetic connectivity of the Indo-Pacific tropical eel Anguilla bicolor". Journal of Biogeography 39 2 (2011): 408-420. http://dx.doi.org/10.1111/j.1365-2699.2011.02603.x.
    10.1111/j.1365-2699.2011.02603.x
  41. Gagnaire, Pierre-Alexandre; Minegishi, Yuki; Zenboudji, Saliha; Valade, Pierre; Aoyama, Jun; Berrebi, Patrick. "WITHIN-POPULATION STRUCTURE HIGHLIGHTED BY DIFFERENTIAL INTROGRESSION ACROSS SEMIPERMEABLE BARRIERS TO GENE FLOW IN ANGUILLA MARMORATA". Evolution 65 12 (2011): 3413-3427. http://dx.doi.org/10.1111/j.1558-5646.2011.01404.x.
    10.1111/j.1558-5646.2011.01404.x
  42. GAGNAIRE, P. A.; ALBERT, V.; JÓNSSON, B.; BERNATCHEZ, L.. "Natural selection influences AFLP intraspecific genetic variability and introgression patterns in Atlantic eels". Molecular Ecology 18 8 (2009): 1678-1691. http://dx.doi.org/10.1111/j.1365-294x.2009.04142.x.
    10.1111/j.1365-294x.2009.04142.x
  43. Gagnaire, PA; Minegishi, Y; Aoyama, J; Réveillac, E; Robinet, T; Bosc, P; Tsukamoto, K; Feunteun, E; Berrebi, P. "Ocean currents drive secondary contact between Anguilla marmorata populations in the Indian Ocean". Marine Ecology Progress Series 379 (2009): 267-278. http://dx.doi.org/10.3354/meps07895.
    10.3354/meps07895
  44. Robinet, T.; Réveillac, E.; Kuroki, M.; Aoyama, J.; Tsukamoto, K.; Rabenevanana, M. W.; Valade, P.; et al. "New clues for freshwater eels (Anguilla spp.) migration routes to eastern Madagascar and surrounding islands". Marine Biology 154 3 (2008): 453-463. http://dx.doi.org/10.1007/s00227-008-0938-7.
    10.1007/s00227-008-0938-7
  45. Gagnaire, P. A.; Tsukamoto, K.; Aoyama, J.; Minegishi, Y.; Valade, P.; Berrebi, P.. "RFLP and semi-multiplex PCR-based identification of four eel species from the south-western Indian Ocean region". Journal of Fish Biology 71 sb (2007): 279-287. http://dx.doi.org/10.1111/j.1095-8649.2007.01605.x.
    10.1111/j.1095-8649.2007.01605.x
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 ·Invited national presentations: Prospectives CNRS-INEE
2021 Invited international presentations: FSBI Symposium, Keynote
2021 ·Invited international presentations: , CeMEB Autumn Assembly, Keynote
2021 ·Invited national presentations: ESEminaires
2021 ·Invited national presentations: MARBEC seminar
2021 ·Invited national presentations: MOI seminar
2019 ·Invited national presentations: EEP lab seminar

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019 - 2023 Evolution des paysages de recombinaison chez les animaux
Supervisor
2019 - 2023 Génomique comparative de la divergence écotypique associée au gradient laguno-marin chez cinq espèces de poissons
Supervisor
2018 - 2022 Rôles des contraintes génomiques et des traits d'histoire de vie dans la spéciation : une approche de génomique comparative
Supervisor
2016 - 2019 Intégrer des approches expérimentales et d’évolution moléculaire en génomique de la spéciation afin d’identifier les mécanismes impliqués dans la divergence entre bar atlantique et loup méditerranéen
Supervisor

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022 - Current ·Symposium co-organisation on the Evolution of recombination genomic landscapes at the ESEB 2022 congress in Prague with Milan Malinsky. (2022)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019 - Current Invited international presentations: iMARCO Conference
Conference

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - 2023 Master 1 BEE Darwin: Co-organizer of the GGE module.

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2022 - Current ·Scientific project evaluator: Icelandic Research Fund (2022)
2022 - Current ·Scientific project evaluator: NERC (2022).
2021 - Current ·Scientific project evaluator: Atlantic Genome Canada (2021)
2020 - Current Scientific project evaluator: Austrian Science Fund FWF
2020 - Current ·Scientific project evaluator: ERC Consolidator (2020)