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Akhilesh Rai has completed Bachelor's (B.Sc.) in Chemistry and Botany, Chemistry from Deen Dayal Upadhyay Gorakhpur University, Master's (M.Sc.) in Biotechnology from Savitribai Phule Pune University and PhD in Biotechnology from Savitribai Phule Pune University. After completing his PhD, he moved to Nottingham Trent University, U.K. to pursue postdoctoral research on European Union FP7 project. In 2010, he moved to Universite Catholique Louvain as a postdoctoral researcher for 1 year. In 2012, he joined as FCT postdoctoral fellow at the Centre for Neuroscience and Cell Biology, Coimbra, Portugal. He was an assistant investigator at the Centre for Neuroscience and Cell Biology from 2013 to 2017 in the project led by Dr. Lino Ferreira. He was awarded the FCT Investigator grant and joined the Faculty of Medicine, University of Coimbra to start his independent group in November 2017. Notably, his team received the first prize at the first phase of the 7th Building Global Innovators (BGI-MIT Program) for the project related to developing a unique wound dressing for treating chronic wounds, which led to the generation of the spinoff company (CureMat Technology). Our work related to antimicrobial nanoparticles has been recognized and I have been conferred the prestigious Bluepharma-University of Coimbra Innovation award (2016) for the project Bug-killer. He has published more than 36 papers in international peer-reviewed journals, 5 book chapters, 1 patent granted (2 patents submitted at PCT level) with citations of more than 7000 and h-index-21. he has edited one book for the Elsevier group and currently editing another book for Springer Nature. He is also an active reviewer of many international journals related to nanotechnology, biodegradable NPs, antimicrobial materials, drug delivery, and antimicrobial surfaces. He supervised 2 PhD students and 8 master students for their theses. Currently, his group has two master's, two PhD students and one postdoctoral researcher. He has actively participated in several international conferences. He is guest editor of the special issues of Nanomaterials and (MDPI publishers) and Frontiers in Nanotechnology, and an associate editor of Frontiers of Medical Engineering. His research interests include the formulation of bioactive and peptide-conjugated nanomaterials and multifunctional coatings in treating oral infections and for regenerative medicine applications. His research group is also involved in the development of light-sensitive nanoparticles for brain targeting and understanding the paracrine effects on the integrity of the blood-brain barrier. His research group is also involved in the development of antimicrobial and bioactive coating on medical devices and implants. Recently, he is granted an FCT project to develop multifunctional dental implants for the treatment of peri-implant diseases. He is a team member of BioRobotbeads and Reset_Bone_Ageing projects funded by the regional fund (Centro2020 Portugal).
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Identification

Personal identification

Full name
Akhilesh Rai

Citation names

  • Rai, Akhilesh

Author identifiers

Ciência ID
3519-CD06-4243
ORCID iD
0000-0001-5352-5415

Email addresses

  • akhilesh.rai@uc.pt (Professional)

Addresses

  • UC-Biotech, 3060-194, Cantanhede, Cantanhede, Portugal (Professional)

Websites

  • http://erachair.uc-biotech.pt (Professional)

Knowledge fields

  • Engineering and Technology - Nano-technology
  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Hindi (Mother tongue)
Portuguese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020/11/09 - 2020/11/20
Concluded
 IV Modular training in Laboratory Animal Science (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2003/01/23 - 2007/12/19
Concluded
 Biotechnology (Doctor of Philosophy)
Major in Especialidade: Biotecnologia
Savitribai Phule Pune University, India
"Size and shape controlled synthesis of metal nanoparticles and its nanocomposites " (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2000/08/01 - 2002/06/30
Concluded
 Biotechnology (Master)
Major in Biotechnology
Savitribai Phule Pune University Department of Biotechnology, India
 First class
1996/07/01 - 1999/05/31
Concluded
 ChemistryBotany, Zoology (Bachelor)
Major in Chemistry and Botany
Deen Dayal Upadhyay Gorakhpur University, India
 Second class
Affiliation

Science

Category
Host institution 		Employer
2017/11/01 - Current Auxiliary Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/11/01 - 2017/10/31 Invited Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09/01 - 2015/09/30 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2011/04 - 2012/08 Postdoctoral researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/02/02 - 2011/01/31 Postdoctoal researcher Université catholique de Louvain Faculté des sciences, Belgium
Université catholique de Louvain Faculté des sciences, Belgium
2007 - 2009 Postdoctoral researcher Nottingham Trent University, United Kingdom
Nottingham Trent University - Clifton Campus, United Kingdom
Projects

Grant

Designation Funders
2021/10/01 - Current Biorobotbead_ Sistema robotizado para a produção de biomateriais e partículas
47081
team member
European Regional Development Fund
Ongoing
2021/10/01 - Current Reset Bone Ageing: Coating for orthopedic prostheses with the ability to increase bone tissue regeneration
Reset_Bone_Ageing _069790
team member
European Regional Development Fund
Ongoing
2022/01/01 - 2024/12/31 Fabrication of light responsive and multifunctional dental implant for the treatment of peri-implant diseases
PTDC/CTM-CTM/1719/2021
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2022/10 NanoNeurogenic: Enhancing brain accumulation by nanoparticle chemistry
(IF/00539/2015
Supervisor
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/11/01 - 2017 Triggerable nanomaterials to modulate cell activity
info:eu-repo/grantAgreement/EC/FP7/307384/EU
Other
European Research Council
Concluded
2010/06/01 - 2014 Antimicrobial coatings- Killmicrob
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105000/PT
Post-doc
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2014/12/01 - 2017 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
info:eu-repo/grantAgreement/FCT/5665-PICT/137185/PT
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2013 - 2015 Stemcell based platforms for Regenerative and Therapeutic Medicine
Centro-07-ST24-FEDER-002008
Researcher
Concluded
2011/04/01 - 2014 DEVELOPMENT OF ANTIMICROBIAL PEPTIDE-BASED COATINGS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F732112%F2010/PT
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2011 Conception de revetements (bio) organiques nano-et micro-structurés pour l'etude de l'adhésion bactérienne
885.324.344
Post-doc Fellow
Fonds de la Recherche Scientific
Concluded

Other

Designation Funders
2012/03/15 - 2015 NANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets
info:eu-repo/grantAgreement/FCT/COMPETE/121650/PT
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Rai, Akhilesh; Sahadevan Seena. Nanoparticles and Plant-Microbe Interactions An Environmental Perspective. 2023.
    Published • Editor
  2. Rai, Akhilesh. Nanotechnology based Strategies for Combating Antimicrobial Resistance. India: Springer Nature. 2023.
    Under revision • Editor
Book chapter
  1. Sahadevan Seena; Rai, Akhilesh. Corresponding author: Rai, Akhilesh. "Nanoengineering approaches to fight multidrug-resistant bacteria". In Non-traditional Approaches to Combat Antimicrobial Drug Resistance. 2023.
    Published
  2. Barros, Juliana; Rai, Akhilesh; Santosh Kumar; Sahadevan Seena. Corresponding author: Sahadevan Seena. "Mega-challenges of nano-metals on micro-decomposers in freshwaters". In Nanoparticles and plant-microbe interactions: An environmental perspective, edited by Sahadevan Seena; Akhilesh Rai; Santosh Kumar. 2023.
    In press
  3. Rai, Akhilesh; Comune, Michela; Ferreira, Lino. "Nanoparticle-Based Drug Delivery Systems: Promising Approaches Against Bacterial Infections". In Antibacterial Drug Discovery to Combat MDR, 605-633. Portugal: Springer Singapore, 2019.
    Accepted • 10.1007/978-981-13-9871-1_27
  4. Rai, Akhilesh. "Biocompatibility Issues of Organic and Inorganic Nanomaterials". In Frontiers in Biomaterials, 274-304. BENTHAM SCIENCE PUBLISHERS, 2014.
    Accepted • 10.2174/9781608058761114010013
Conference abstract
  1. Gagliardi, Teresa; Palma, Paulo J.; Chiara Tonda-Turo; Rai, Akhilesh. Corresponding author: Rai, Akhilesh. "Light-responsive and multifunctional antimicrobial coatings to prevent peri-implantitis". Paper presented in European Society of Biomaterials 2023, Davos, 2023.
  2. Rai, Akhilesh. "Immobilization of Cecropin-melittin antimicrobial peptide onto polyurethane to prevent infections without inducing thrombus formation". Paper presented in 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, Porto, 2017.
  3. Rai, Akhilesh. "Biocompatible antimicrobial peptide conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model". Paper presented in III Simposia De Nanociencia E Nanotechnologia Biomedica (Nano2016PT), Lisbon, 2016.
  4. Rai, Akhilesh. "Biocompatible antimicrobial peptide (AMP) conjugated gold nanoparticles with high stability against serum and protease". Paper presented in Eurpean Society of Biomaterials, 2013.
  5. Rai, Akhilesh. "An antimicrobial surface with potent antimicrobial activity and low cytotoxicity against human cells". Paper presented in European Biomaterials Society, Madrid, 2013.
  6. Rai, Akhilesh. "Cecropin-mellitin modified surfaces exhibit high antimicrobial activity and low cytotoxicity against human cells". Paper presented in Socienty for Biomaterials Spring meeting, 2013.
  7. Rai, Akhilesh. "Design of potent antimicrobial and biocompatible gold nanoparticles". Paper presented in NanoPT Conference, Porto, 2013.
  8. Rai, Akhilesh. "One pot synthesis of potent antimicrobial gold nanoparticles". Paper presented in Trends in Nanotechnology Conference, 2012.
  9. Rai, Akhilesh; Rai, A.; Prabhune, A.; Perry, C.C.. "Antibiotics mediated synthesis of gold nanoparticles with potent antimicrobial activity and their applications in antimicrobial coatings". Paper presented in Material Research Society (MRS) conference, 2010.
    10.1039/c0jm00817f
  10. Rai, Akhilesh. "The facile fabrication of controlled thickness silica films on solid surfaces using a bio-inspired approach". Paper presented in Material Research Society (MRS) conference, 2009.
  11. Rai, Akhilesh. "Synthesis of Au-Ag core-shell nanoparticles and its application in SERS". Paper presented in International Conference on Nanomaterials (Nano 2005), Shivakshi, 2005.
Conference poster
  1. A. Sofia Pinho; Renato Pereira; Mariana G. Pereira; Rai, Akhilesh; Lino Ferreira; M. Cristina L. Martins; Paula Parreira. "The art of deceiving: lipid-based decoys for Helicobacter pylori infection management". Paper presented in XXXVIth Workshop of the European Helicobacter and Microbiota Study Group - EHMSG 2023, 2023.
  2. Rai, Akhilesh; Catarina Praca; Lino Ferreira. "Targeting the Neurogenic Niches of Adult Brain by Peptide Conjugated Nanoparticles". Paper presented in European Society of Biomaterials, 2018.
  3. Akhilesh Rai; Andre F. Ferreira; Lino Ferreira; Pedro N. Simões. "Molecular Dynamics Investigation Of The Interaction Of A Cecropin Melettin Peptide With Gold Surfaces". Paper presented in ChemPor, 2014.
  4. Rai, Akhilesh. "Halide ions mediated shape change in gold nanotriangles". Paper presented in International Conference on Nanoscience and Technology (ICONSAT 2006), 2006.
  5. Rai, Akhilesh. "Reshaping of gold nanoparticles using chemical means". Paper presented in International Nanotechnology and Biotechnology Conference (INBC 2006), 2006.
Journal article
  1. Rafaela Ferrao; Simoes, Susana MN; Lino Ferreira; Rai, Akhilesh. "Effect of near-infrared light-responsive and non-immunogenic nanoparticles on the integrity of the blood-brain barrier and their accumulation in the brain". Biomaterials Advances (2023):
    Submitted
  2. Rai, Akhilesh; Sahadevan Seena; Gagliardi, Teresa; Palma, Paulo J.. Corresponding author: Rai, Akhilesh. "Advances in design of amino acid and peptide synthesized gold nanoparticles for their applications". Advances in Colloid and Interface Science (2023):
  3. Diogo, Patrícia; Amparo F. Faustino, M.; Palma, Paulo J; Rai, Akhilesh; Graça P. M. S. Neves, Maria; Miguel Santos, João. "May carriers at nanoscale improve the Endodontic’s future?". Advanced Drug Delivery Reviews 195 (2023): 114731. http://dx.doi.org/10.1016/j.addr.2023.114731.
    10.1016/j.addr.2023.114731
  4. Sahadevan Seena; Rafaela Ferrao; Melike Pala; S.L.K.W. Roelants; Wim Soetaert; Christian V. Stevens; Lino Ferreira; Rai, Akhilesh. Corresponding author: Rai, Akhilesh. "Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents". Biomaterials Advances (2023): https://www.sciencedirect.com/science/article/abs/pii/S2772950823000225.
    Published
  5. Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Miguel Lino; Tiago Rondão; Jian Ji; Artur Paiva; Lino Ferreira. "Antimicrobial Peptide-Tether Dressing Able to Enhance Wound Healing by Tissue Contact". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c06601.
    10.1021/acsami.2c06601
  6. Akhilesh Rai; Rafaela Ferrão; Paulo Palma; Tatiana Patricio; Paula Parreira; Elsa Anes; Chiara Tonda-Turo; et al. "Antimicrobial peptide-based materials: opportunities and challenges". Journal of Materials Chemistry B 10 14 (2022): 2384-2429. https://doi.org/10.1039/D1TB02617H.
    In press • 10.1039/D1TB02617H
  7. Rai, Akhilesh; Ferreira, Lino. "Biomedical applications of the peptide decorated gold nanoparticles". Critical Reviews in Biotechnology 41 2 (2021): 186-215. http://dx.doi.org/10.1080/07388551.2020.1853031.
    10.1080/07388551.2020.1853031
  8. Luís Estronca; Vitor Francisco; Patrícia Pitrez; Inês Honório; Lara Carvalho; Helena Vazão; Josephine Blersch; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions". Nanoscale Horizons (2021): https://doi.org/10.1039/D0NH00550A.
    10.1039/D0NH00550A
  9. Michela Comune; Akhilesh Rai; Paulo Palma; Chiara TondaTuro; Lino Ferreira. "Antimicrobial and pro-angiogenic properties of soluble and nanoparticle-immobilized LL37 peptides". Biomaterials Science (2021): https://doi.org/10.1039/D1BM01034D.
    10.1039/D1BM01034D
  10. Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez, Adrián; Antunes, Helena; Pinto, Sandra; Simoes, Susana MN; Rai, Akhilesh; Ferreira, Lino. "A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1A (HIF-1A)". Nanoscale 12 (2020): 9935-9942. http://dx.doi.org/10.1039/c9nr10503d.
    10.1039/c9nr10503d
  11. Querido, Micaela M.; Felgueiras, Helena P.; Rai, Akhilesh; Costa, Fabíola; Monteiro, Claudia; Borges, Inês; Oliveira, Diana; Ferreira, Lino; Martins, Maria Cristina Lopes. "Cecropin-Melittin Functionalized Polyurethane Surfaces Prevent Staphylococcus epidermidis Adhesion without Inducing Platelet Adhesion and Activation". Advanced Materials Interfaces 5 24 (2018): 1801390. http://dx.doi.org/10.1002/admi.201801390.
    Accepted • 10.1002/admi.201801390
  12. Ferreira, André F.; Comune, Michela; Rai, Akhilesh; Ferreira, Lino; Simões, Pedro N.. "Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics". The Journal of Physical Chemistry B 122 35 (2018): 8359-8366. http://dx.doi.org/10.1021/acs.jpcb.8b05717.
    Accepted • 10.1021/acs.jpcb.8b05717
  13. Praça, Catarina; Rai, Akhilesh; Santos, Tiago; Cristovão, Ana C.; Pinho, Sonia L.; Cecchelli, Romeo; Dehouck, Marie-Pierre; Bernardino, Liliana; Ferreira, Lino S.. "A nanoformulation for the preferential accumulation in adult neurogenic niches". Journal of Controlled Release 284 (2018): 57-72. http://dx.doi.org/10.1016/j.jconrel.2018.06.013.
    Accepted • 10.1016/j.jconrel.2018.06.013
  14. Saraiva, Cláudia; Talhada, Daniela; Rai, Akhilesh; Ferreira, Raquel; Ferreira, Lino; Bernardino, Liliana; Ruscher, Karsten. "MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo". PLOS ONE 13 3 (2018): e0193609. http://dx.doi.org/10.1371/journal.pone.0193609.
    Accepted • 10.1371/journal.pone.0193609
  15. Michela Comune; Akhilesh Rai; Kiran K. Chereddy; Sandra Pinto; Sezin Aday; André F. Ferreira; Alessandra Zonari; et al. "Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential". Journal of Controlled Release 262 (2017): 58-71. https://doi.org/10.1016/j.jconrel.2017.07.007.
    10.1016/j.jconrel.2017.07.007
  16. Ferreira, A.F.; Rai, A.; Ferreira, L.; Simões, P.N.. "Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies". European Biophysics Journal 46 3 (2017): 247-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979994138&partnerID=MN8TOARS.
    10.1007/s00249-016-1160-z
  17. Maleki, H.; Rai, A.; Pinto, S.; Evangelista, M.; Cardoso, R.M.S.; Paulo, C.; Carvalheiro, T.; et al. "High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide". ACS Applied Materials and Interfaces 8 18 (2016): 11366-11378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974846183&partnerID=MN8TOARS.
    10.1021/acsami.6b03355
  18. Rai, A.; Pinto, S.; Velho, T.R.; Ferreira, A.F.; Moita, C.; Trivedi, U.; Evangelista, M.; et al. "One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model". Biomaterials 85 (2016): 99-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958212359&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.01.051
  19. Rai, Akhilesh; Prabhune, Asmita; Perry, Carole C.. "Entrapment of commercially important invertase in silica particles at physiological pH and the effect of pH and temperature on enzyme activity". Materials Science and Engineering: C 32 4 (2012): 785-789. http://dx.doi.org/10.1016/j.msec.2012.01.026.
    Accepted • 10.1016/j.msec.2012.01.026
  20. Rai, A.; Perry, C.C.. "Mussel adhesive protein inspired coatings: A versatile method to fabricate silica films on various surfaces". Journal of Materials Chemistry 22 11 (2012): 4790-4796. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857508380&partnerID=MN8TOARS.
    10.1039/c2jm15810h
  21. Hickman, G.J.; Rai, A.; Boocock, D.J.; Rees, R.C.; Perry, C.C.. "Fabrication, characterisation and performance of hydrophilic and super-hydrophilic silica as cell culture surfaces". Journal of Materials Chemistry 22 24 (2012): 12141-12148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862217742&partnerID=MN8TOARS.
    10.1039/c2jm31161e
  22. Rai, A.; Perry, C.C.. "Facile fabrication of uniform silica films with tunable physical properties using silicatein protein from sponges". Langmuir 26 6 (2010): 4152-4159. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952966218&partnerID=MN8TOARS.
    10.1021/la903366a
  23. Rai, A.; Perry, C.C.. "Fabrication of tuneable thickness silica films on solid surfaces using amines and proteins". Silicon 1 2 (2009): 91-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957923654&partnerID=MN8TOARS.
    10.1007/s12633-009-9012-4
  24. Rai, A.; Chaudhary, M.; Ahmad, A.; Bhargava, S.; Sastry, M.. "Synthesis of triangular Au core-Ag shell nanoparticles". Materials Research Bulletin 42 7 (2007): 1212-1220. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247473125&partnerID=MN8TOARS.
    10.1016/j.materresbull.2006.10.019
  25. Rai, A.; Singh, A.; Ahmad, A.; Sastry, M.; Rai, Akhilesh. "Role of halide ions and temperature on the morphology of biologically synthesized gold nanotriangles". Langmuir 22 2 (2006): 736-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-31544434865&partnerID=MN8TOARS.
    10.1021/la052055q
  26. Shankar, S.S.; Rai, A.; Ahmad, A.; Sastry, M.. "Controlling the optical properties of lemongrass extract synthesized gold nanotriangles and potential application in infrared-absorbing optical coatings". Chemistry of Materials 17 3 (2005): 566-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444291501&partnerID=MN8TOARS.
    10.1021/cm048292g
  27. Shankar, S.S.; Rai, A.; Ahmad, A.; Sastry, M.. "Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth". Journal of Colloid and Interface Science 275 2 (2004): 496-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942564380&partnerID=MN8TOARS.
    10.1016/j.jcis.2004.03.003
  28. Shankar, S.S.; Rai, A.; Ankamwar, B.; Singh, A.; Ahmad, A.; Sastry, M.. "Biological synthesis of triangular gold nanoprisms". Nature Materials 3 7 (2004): 482-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042832367&partnerID=MN8TOARS.
    10.1038/nmat1152
Thesis / Dissertation
  1. Monteiro, Denise Irene Marta. "THERAPEUTIC EFFECTS OF NOVEL DRESSING COATED WITH LL37-AuNP FOR THE ENHANCED WOUND HEALING". Master, Universidade de Coimbra Faculdade de Farmácia, 2019. http://hdl.handle.net/10316/88197.
  2. Rai, Akhilesh. "Wound healing and pro-angiogenic properties of LL37-conjugated nanoparticles". PhD, 2015.

Intellectual property

Patent
  1. Rai, Akhilesh. 2015. "Antimicrobial coating compositions".
Provisional application for patent
  1. 2021. "PROCESS TO COAT A MEDICAL DEVICE SURFACE WITH PEPTIDE-BASED NANOPARTICLES".
    Disclosed
  2. 2020. "CHOLESTEROL/ETHYLENE GLYCOL GOLD NANOPARTICULES FOR TREATMENT OF HELICOBACTER PYLORI INFECTION".
    Disclosed

Other

Other output
  1. High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells. Medical device-associated infections are a multi-billion dollar burden for the worldwide healthcare systems. The modification of medical devices with non-leaching coatings capable of killing microorganisms on contact is one of the strategies being investigated to prevent microorganism colonization. Here we developed a robust antimicrobial coating based on the chemical immobilization of the antimic. 2016. Rai, Akhilesh; Pinto, Sandra; Evangelista, Marta B.; Gil, Helena; Kallip, Silvar; Ferreira, Mario G. S.; Ferreira, Lino; et al. http://hdl.handle.net/10773/19977.
    10.1016/j.actbio.2016.01.035
Spin-off company
  1. 2018. CureMat Technology. Development of wound dressing.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09 To reset the senescence program in senescent stem/progenitor cells by extracellular vesicles European Society of Biomaterials 2023
2023/09 Light-responsive and multifunctional antimicrobial coatings to prevent peri-implantitis European Society of Biomaterials 2023
(Davos, Switzerland)
2023/06 Synergistic antimicrobial effect between antimicrobial peptides conjugated nanoparticles European Society of Clinical Investigation
(Prague, Czech Republic)
2022/09/04 Immunotoxicity caused by near-infrared light-responsive nanoparticles on the integrity of the blood-brain barrier European Society of Biomaterials
(France)
2022/08/12 Immunotoxicity evaluation of light-responsive nanoparticles to the integrity of blood-brain barrier model International Online Conference on Nano Materials (ICN 2022)
(India)
2022/07/19 Near-infrared light-responsive nanoparticles as an efficient carrier to cross the blood-brain barrier Junior Euromat 2022
University of Coimbra (Coimbra)
2022/06/20 Antimicrobial peptide-based nanoformulations: Fight bacteria and promote tissue regeneration 8th International IBERIAN BIOPHYSICS CONGRESS
Spanish Biophysical Society (Bilbao, Spain)
2022/05/29 Design of antimicrobial peptide-based materials to fight infections and promote skin regeneration 5th Congress of the Hellenic Society of Gene Therapy and Regenerative Medicine
Hellenic Society (Thessaloniki, Greece)
2021/09/06 Peptide conjugated light-responsive NPs to target blood brain barrier European Society of Biomaterials
(Porto, Portugal)
2021/03/24 Peptide conjugated light-responsive NPs to target blood brain barrier Drug Delivery Webinar
(United Kingdom)
2021/03/24 Peptide decorated gold nanoparticles and their applications in wound healing and brain targeting Faculty Development Programme on 'Nanomaterials for Next Generation Applications
Indian Institute of technology Indore, India (Indore)
2019 Peptide conjugated nanoparticles and their biomedical applications V Semana da Bioengenharia
Instituto Superior Técnico (Lisbon, Portugal)
2019 Nanotechnology and Biomedical applications VII AEICBAS Biomedical Congress
University of Porto (Porto, Portugal)
2017/05/21 Antimicrobial peptide conjugated gold nanoparticles with their antimicrobial efficacy in systemic infection model 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2017, Porto
University of Porto (Porto, Portugal)
2017/05/17 Peptide conjugated nanoparticles and their biomedical applications II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
Faculty of Health Sciences of University of Beira Interior (Covilhã, Portugal)
2017 Antimicrobial peptide conjugated gold nanoparticle with enhanced skin regeneration property Portuguese Society for Stem Cells and Cell Biology
University of Beira Interior (Covilha, Portugal)
2017 Targeting the Neurogenic Niches of Adult Brain by Nanoparticles Portuguese Society of Stem Cells and Cell Biology
University of Beira Interior (Covilha, Portugal)
2013 Design of potent antimicrobial and biocompatible gold nanoparticles Nanoscience and Nanotechnology International Conference (NanoPT 2013)
(Porto, Portugal)
2013 An antimicrobial surface with potent antimicrobial activity and low cytotoxicity against human cells European Society of Biomaterials
(Madrid, Spain)
2013 Biocompatible antimicrobial peptide (AMP) conjugated gold nanoparticles with high stability against serum and proteases European Society of Biomaterials
(Madrid, Spain)
2013 Cecropin-mellitin modified surfaces exhibit high antimicrobial activity and low cytotoxicity against human cells ASB Spring meeting
(Boston, United States)
2012 Design of potent antimicrobial and biocompatible gold nanoparticles Trends in Nanotechnology International Conference (TNT2012)
(Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/03/30 - Current Design of multifuctional dental implants to prevent per-implantitis
Supervisor
Universidade de Coimbra, Portugal
2022/09 - Current Molecular dynamics approach to understand the interaction of conjugated antimicrobial peptides with the bacterial memrbane
Supervisor
 Chemical Enginering (Master)
Universidade de Coimbra, Portugal
2022/01 - Current Light-responsive NPs to deliver senolytic drugs to aged brain
Supervisor
 Life Science (PhD)
Universidade de Coimbra, Portugal
2012 - Current Wound healing and pro-angiogenic properties of LL37-conjugated nanoparticles
Co-supervisor
 Bioscience in area of Biotechnology (PhD)
2022/03/15 - 2022/10 Development of NIR light-responsive nanoparticles coating on implants to prevent infections
Supervisor
 Chemistry (Master)
Universidade de Coimbra, Portugal
2021/09/01 - 2022/09 Antimicrobial materials for dental applications
Co-supervisor
 Biomedical Engineering (Master)
Universidade de Coimbra, Portugal
2019/05/01 - 2019/11/30 Development of antimicrobial nanofibers to treat dental infection
Co-supervisor
 Biomedical Engineering (Master)
2019/05/01 - 2019/11/30 Antimicrobial nanofibers for dental regeneration and to control microbial infection
Co-supervisor
 Biomedical Engineering (Master)
Politecnico di Torino, Italy
2018/09/01 - 2019/09/06 Therapeutic effects of novel LL37-AuNPs coated dressing for the enhanced wound healing
Supervisor of Denise Marta
 Pharmaceutical Biotechnology (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016 - Current Attended Entrepreneurship program at Building Global Innovation, (MIT-Portugal program), Lisbon 2016
Workshop
 Building Global Innovation

Conference scientific committee

Conference name Conference host
2023/03 - Current European Society of Biomaterials 2023

Consulting

Activity description Institution / Organization
2012 - Current NANOECOTOX-Impacts of metal nanoparticles to aquatic ecosystems: from community responses to cellular targets (Centre of Molecular and Environmental Biology) University of Minho, Braga. Universidade do Minho, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Biomedical Engineering 2019-2020 Biomedical Engineering (Mestrado integrado) Universidade de Coimbra, Portugal
2019 - Current 2018-2019 Biomedical Engineering (Mestrado integrado) Universidade de Coimbra, Portugal
2019 - Current 2019-2020 PhDBEB (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/04 - Current I am a reviewer of European Society of Biomaterials 2021 and 2023 conferences to evaluate the submitted abstracts.
Evaluator

Interview (tv / radio show)

Program Topic
2023/03/20 - Current Olhó Robot" #16: International Brain Week: Drug delivery to the brain. Interviewed by Luís Pereira (available as podcast).

Journal scientific committee

Journal title (ISSN) Publisher
2022/12/01 - Current Frontiers in Medical Engineering
2021 - Current Journal of Applied Biopharmaceutics and Pharmacokinetics (2309-4435) Scientific Array
2021 - Current Frontiers in Nanotechnology Frontiers
2020/07/10 - Current Nanomaterials (2079-4991) MDPI
2020/07/01 - Current Antibiotics (2079-6382) MDPI AG

Mentoring / Tutoring

Topic Student name
2023/01/23 - Current Coating of dual antimcirobial peptide-conjugated NPs on surfaces Diogo Cruz
2022/10/01 - Current Therapeutic. evaluation of multifunctional dental implants in vitro and in vivo model Claudia Deus
2020/01 - Current Skin regeneration using light responsive NPs Rafaela Ferrão
2021/03 - 2021/12 Brain targeting using near infrared light-sensitive NPs Rafaela Ferrão
2019/07/09 - 2019/09/06 Synthesis of light sensitive nanoparticles for drug delivery application Laressa Leite
2018/09/06 - 2019/08/10 Formulation of biodegradable nanoparticles (NPs) encapsulated with a senotherapeutic Ana Cunha
2018/10/01 - 2018/11/06 To understand the mechanism of diabetic wound healing Ana Costa
2018/04/04 - 2018/07/31 Development of antimicrobial wound dressing Fabio Vidal
2018/03/05 - 2018/04/30 Formulation of biodegradable nanoparticles Adelaide Barbosa
2016/12/01 - 2017/09/30 Development of biodegradable nanoformulation to deliver small molecules Josephine Blersch

Other jury / evaluation

Activity description Institution / Organization
2020 - Current I am a team member of Reviewer Board of Pharmaceutics Journal from MDPI group.
2017/12/01 - Current I am reviewers of several journals such as ACS Applied Materials & Interfaces, Acta Biomaterialia, Colloids & Surfaces B, Macromolecule Biosciences and other journals related to Nanobiotechnology.
Distinctions

Award

2017 FCT Investigator award
2015 Innovation award
Bluepharma, Portugal

Universidade de Coimbra, Portugal
2011 FCT postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2003 Junior Research Fellowship
Council of Scientific & Industrial Research, India
2000 Fellowship
Savitribai Phule Pune University Department of Biotechnology, India

Other distinction

2018 Co founder