Carla Patricia Costa Lima (3514-AAA6-3E95)

Curriculum Vitae

Carla Patricia Costa Lima

Carla Lima obtained his First Degree in Chemistry in 2020 and his Master’s Degree in chemistry at the Faculty of Sciences of the University of Porto (FCUP) in 2022. During his Master's Thesis, he performed his work in the Medicinal Chemistry Group of FCUP, under the supervision of Doctor Sofia Benfeito, entitled “Development of new multitarget-directed ligands with potential application in Alzheimer’s disease”. After the MSc completion, Carla became a research fellow in the same group and his work focused on the development of bona fide targeted covalent inhibitors to unravel NOX2 (2022-2023). Later in 2023, she was awarded a PhD Research Scholarship from Fundação para a Ciência e Tecnologia and she’s currently a PhD student in chemistry under the supervision of Doctor Sofia Benfeito. Carla’s research interests include neurodegenerative disease, Targeted Drug Delivery, and Medicinal Chemistry.

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Identification

Personal identification

Full name: Carla Patricia Costa Lima

Citation names

Lima, Carla

Author identifiers

Ciência ID: 3514-AAA6-3E95
ORCID iD: 0000-0001-9389-686X
Scopus Author Id: 57206493270

Email addresses

up201705563@fc.up.pt (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences
Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)	Intermediate (B1)
Portuguese (Mother tongue)

Education

	Degree	Classification
2023/09/12 - 2027/09 Ongoing	Doutoramento em química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2020/09/28 - 2022/10 Concluded	Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal "Development of new multitargetdirected ligands with potential application in Alzheimer's disease" (THESIS/DISSERTATION)	16
2017/09/13 - 2020/09/29 Concluded	Química (Licenciatura) Major in Formação complementar Centrada em Química Universidade do Porto Faculdade de Ciências, Portugal "A importância das fluoroquinolonas como agentes antibacterianos" (THESIS/DISSERTATION)	13

Affiliation

Others

	Category Host institution	Employer
2023/09/12 - Current	PhD Student Fellow	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal
2022/10/15 - 2023/07/31	Master Research Fellow (NOXIous Project - EXPL/BIA-BQM/0492/2021)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal

Projects

Grant

	Designation	Funders
2022/10/15 - 2023/07/31	Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 Research Fellow Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Contract

	Designation	Funders
2023/01 - Current	DeFend: De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators 2022.04633.PTDC PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal

Outputs

Publications

Conference abstract	Castelôa, Mariana; Massari, Marta; Marchese, Sara; Lima, Carla; Reis, Joana; Basile, Lorenzo; Borges, Fernanda; et al. "Advancing NOX Inhibition: Development of Potent and Isoform-Selective Targeted Covalent Inhibitors". Paper presented in 32nd Young Research Fellows Meeting, Paris, 2025. Published Mariana Castelôa; Joana Reis; Carla Lima; Marta Massari; Sara Marchese; Lorenzo Basile; Fernanda Borges. "Insights into the Development of Isoform-Selective, Non-Interfering NOX Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network & COST ACTION, Rome, 2024. Mariana Castelôa; Carla Lima; Sofia Benfeito; Brandon Aguiar; Pedro Soares; Fernanda Borges; Daniel Chavarria. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network, Roma, 2023. Mariana Castelôa; Pedro Soares; Sofia Benfeito; Carla Lima; Fernanda Borges; Daniel Chavarria. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Galician-Portuguese International Conference on Chemistry, Santiago Compostela, 2022. Published
Conference poster	Alves, Catarina; Lima, Carla; Chavarria, Daniel; Cagide, Fernando; Currais, Antonio; Maher, Pamela; Teixeira, José; et al. "Targeting Mitochondrial Iron in Friedreich’s Ataxia". 2025. Carla Lima; Letícia Soares; Catarina Alves; Daniel Chamaria; Lisa Sequeira; Fernando Cagide; Fernanda Borges; Sofia Benfeito. "Getting around on Friedrich ataxia: development of new mitochondriotropic strategies". Paper presented in Ciência 2024: + Ciência para uma só saúde para o bem-estar global, 2024. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Paper presented in Encontro Ciência 2024, 2024. Mariana Castelôa; Joana Reis; Carla Lima; Marta Massari; Sara Marchese; Lorenzo Basile; Fernanda Borges; et al. "Insights into the Development of Isoform-Selective, Non-Interfering Nox Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network Rome, Italy, 2024. Carla Lima; Catarina Alves; Lisa Sequeira; Fernando Cagide; Fernanda Borges; Sofia Benfeito. "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network Rome, Italy, 2024. Soares, Letícia; Lima, Carla; Chavarria, Daniel; Lisa, Sequeira; Alves, Catarina; Borges, Fernanda; Benfeito, Sofia; et al. "Development of new iron chelators targeting mitochondria with potencial application in friedreich ataxia". Paper presented in IJUP - Encontro de Investigação Jovem, 2024. Castelôa, Mariana; Lima, Carla; Benfeito, S.; Brandon Aguiar; Soares Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the Reactivity and Drug-like Profile of Potential Covalent NOX2 Inhibitors". Paper presented in MedChem 2023 - XII Paul Ehrlich Euro-PhD Network meeting, 2023. Lima, Carla; Benfeito, Sofia ; Borges, Fernanda. "New Multitarget-directed ligands for the treatment of Alzheimer's disease". Paper presented in Mitochondrial physiology, redox biology, and genetics. International Meeting, May 12 and 13, 2023. Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Paper presented in II TOXRUN International Congress 2023, 2023. Mariana Casteloa; Pedro Soares; Sofia Benfeito; Carla Lima; Fernanda Borges; Daniel Chavarria. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego Português de Química, 2022. Carla Lima; Fernanda Borges; Sofia Benfeito. "New Multitarget-directed ligands for the treatment of Alzheimer's disease". Paper presented in 1º Congresso de Ciências, 2022. Vera silva; Sofia Benfeito; Inês Costa; Carla Lima; Daniel Chavarria; Fernando Remião; Fernanda Borges; Renata Silva. "Evaluation of cytotoxic and neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson's disease". Paper presented in MedChem 2022 - XI Paul Ehrlich Euro-PhD Network meeting, 2022.
Journal article	Benfeito, Sofia; Albuquerque, Bárbara; Sequeira, Lisa; Lima, Carla; Chavarria, Daniel; Serrão, Paula; Cagide, Fernando; Soares-da-Silva, Patrício; Borges, Fernanda. "Discovery of a Potent, Selective, and Blood-Brain Barrier Permeable Non-nitrocatechol Inhibitor of Catechol-O-methyltransferase". Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1021/acs.jmedchem.4c01682. 10.1021/acs.jmedchem.4c01682 Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; et al. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". European Journal of Medicinal Chemistry 243 (2022): 114740. http://dx.doi.org/10.1016/j.ejmech.2022.114740. 10.1016/j.ejmech.2022.114740
Thesis / Dissertation	"A importância das fluoroquinolonas como agentes antibacterianos". Degree, 2020.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/04/03	The quest for isoform-selective NOX inhibitors: challenges and advances	20th Hellenic Symposium on Medicinal Chemistry (Loannina, Greece)
2025/04	Addressing Mitochondrial Iron Dysregulation in Friedreich’s Ataxia	2nd International Electronic Conference on Antioxidants (IECAN2025) (Portugal)
2025/02/26	Innovative Approaches to Friedreich’s Ataxia Treatment	SCT Young Research Fellows Meeting Faculty of Sciences of University of Porto (Paris, France)
2025/02/26	Advancing NOX Inhibition: Development of Potent and Isoform- Selective Targeted Covalent Inhibitors	SCT Young Research Fellows Meeting Faculty of Sciences of University of Porto (Paris, France)
2022/11/17	Development of new multitarget-directed ligands with potential application in Alzheimer's disease	XXVI Encontro Galego-Português de Química Faculdade de Química da Universidade de Santiago de Compostela (Santiago Compostela, Spain)
2022/05/05	Development of new multitarget-directed ligands with potential application in Alzheimer's disease	IJUP’22 – 15º Encontro de Investigação Jovem da Universidade do Porto Universidade do Porto (Porto, Portugal)
2022/04/27	Development of new multitarget-directed ligands with potential application in Alzheimer's disease	Seminário Cientifico do Mestrado de Química Faculdade de Ciências da Universidade do Porto (Porto, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12) (2023/06/26 - 2023/07/12)	Erasmus Plus, Netherlands Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal Università degli Studi di Cagliari, Italy Università degli Studi di Pisa, Italy Universiteit Gent Faculteit Farmaceutische Wetenschappen, Belgium

Event participation

	Activity description Type of event	Event name Institution / Organization
2022/04/21 - 2022/04/24	Demonstração do curso de química pela Faculdade de Ciências da Universidade do Porto no pavilhão multiusos de Gondomar Exhibition	Mostra da UP 19º Universidade do Porto, Portugal
2018/04/12 - 2018/04/15	Demonstração do curso de química pela Faculdade de Ciências da Universidade do Porto nas instalações ICBAS/FFUP Exhibition	Mostra da UP 16º Universidade do Porto, Portugal
2018/02/22 - 2018/02/23	Demostração de várias atividade na Faculdade de Ciências da Universidade do Porto Exhibition	Dias Abertos FCUP 2018 Universidade do Porto Faculdade de Ciências, Portugal

Association member

	Society Organization name	Role
2022 - Current	Centro de Investigação em Química da Universidade do Porto