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Daniela Cunha-Garcia graduated in Applied Biology from the University of Minho (UM) in 2017. Then, she volunteered as a trainee at the Life and Health Sciences Research Institute (ICVS, UM), working in neurodegenerative diseases, specifically the Machado-Joseph disease (MJD). She integrated the project entitled "Pathogenesis and Therapeutics of Machado-Joseph disease" as a member of the Translational Neurogenetics research team, led by Patrícia Maciel. Her participation in this project was focused on testing and developing therapeutic approaches for MJD. She finished her MSc in Health Sciences (UM) in 2021, with the thesis entitled:" Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease". In her master thesis, she focused on studying the involvement of (dys)functional astrocytes in the onset and progression of MJD. During these periods, she was a co-author in 2 research articles in peer-reviewed journals (Molecular Neurobiology IF=4.6 and Neuroscience IF=3.1), one of which as a second author. She also worked as a researcher in an ongoing study under the project "Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia". Currently, she is a PhD student at the ICVS, where she is focused on exploring the involvement of muscular pathology in Machado-Joseph disease and its potential as an early biomarker of the disease.
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Identification

Personal identification

Full name
DANIELA RAQUEL CUNHA GARCIA
Date of birth
1995/04/15
Gender
Female

Citation names

  • Cunha-Garcia, Daniela

Author identifiers

Ciência ID
331A-5378-72B8
ORCID iD
0000-0001-6090-3517

Email addresses

  • id9961@alunos.uminho.com (Professional)
  • danielacunhagarcia@gmail.com (Personal)

Telephones

Telephone
  • 253604835 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho; ICVS/3B’s - PT Government Associate Laboratory. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Exact Sciences - Mathematics - Statistics and Probability

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2022/04/01 - 2026/03/31
Ongoing
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
2018 - 2021
Concluded
 Health Sciences (Mestrado)
Major in Neuroscience
Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease " (THESIS/DISSERTATION)
 17
2018 - 2018
Concluded
 LABORATORY ANIMAL SCIENCE - according to FELASA category C recommendations (Pós-Graduação)
Major in Animal Science
Universidade do Minho Escola de Medicina, Portugal
 16
2014 - 2017
Concluded
 Applied Biology (Licenciatura)
Major in Biologia
Universidade do Minho Escola de Ciências, Portugal
"Implementation of lung slice culture for the study of alveologenesis in pulmonary physiology. " (THESIS/DISSERTATION)
 14
2010 - 2014
Concluded
 Ciências e Tecnologia (Ensino secundário)
Major in Ciências e Tecnologia
Escola Secundária Alberto Sampaio, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2021/07/23 - 2022/03/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Others

Category
Host institution 		Employer
2021/03 - 2021/07/22 Research Trainee Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
(...)
2017/09 - 2018/09 Research Trainee Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
(...)
Projects

Grant

Designation Funders
2021/07/23 - 2022/03/31 Determining the Efficacy of NLX-112 in a Mouse Experimental Model of Cerebellar Ataxia
ID3624
Researcher
Universidade do Minho, Portugal
Ongoing
2018 - 2019 Role of glial cells in the neurodegenerative process in Machado-Joseph disease.
PTDC/NEU-NMC/3648/2014
Estudante de Mestrado - Estagiário
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Gomes, Patrícia ; Duarte-Silva, Sara; Maciel, Patrícia. "Assessing the HPA-axis mediated stress responses in a mouse model of SCA3". Paper presented in 11th IBRO World Congress of Neuroscience, Granada, 2023.
    Published • 10.1016/j.ibneur.2023.08.1082
Conference poster
  1. Cunha-Garcia, Daniela ; Duarte-Silva, S; Maciel, Patrícia. "The skeletal muscle in SCA3: contribution to disease, potential for biomarker development and therapeutic target". Paper presented in Postgraduate Students Retreat MSc or PhD, grab your future, 2023.
  2. Ferreira-Lomba, Bruna; Guerreiro, Sara R; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et.al.; Maciel Patrícia. Corresponding author: Maciel Patrícia. "Motor coordination and balance ameliorated after treatment of the CMVMJD135 mouse model of Spinocerebellar Ataxia Type 3 with befiradol". Paper presented in International Congress for Ataxia Research (ICAR), 2022.
  3. Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al.; Maciel Patrícia. Corresponding author: Maciel Patrícia. "Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease". Paper presented in International Society for Neurochemistry-Asian Pacific Society of Neurochemistry (ISN-APSN), 2022.
  4. Ferreira-Lomba, Bruna; Guerreiro, Sara; Cunha-Garcia, Daniela ; Duarte-Silva, S; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Vidinha-Mira, André; et al.; Maciel Patrícia. Corresponding author: Maciel Patrícia. "Pre- and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS), 2022.
  5. Vidinha-Mira, André; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Vieira, Carmen ; Cunha-Garcia, Daniela ; Ferreira-Lomba, Bruna; Oliveira, Stéphanie; et al. "Does activation of serotonergic treatment suppress proteotoxicity in mouse models of neurodegenerative diseases?". Paper presented in Sixteenth - Young European Scientist (YES) Meeting, 2021.
  6. Guerreiro, Sara; Ferreira-Lomba, Bruna; Duarte-Silva, S; Cunha-Garcia, Daniela ; Vidinha-Mira, André; Vilasboas-Campos, Daniela; Teixeira-Castro, Andreia; Maciel, Patrícia. Corresponding author: Maciel, Patrícia. "NLX-112 improved the motor coordination and balance in a mouse experimental model of Machado-Joseph Disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  7. Vidinha-Mira, André; Monteiro-Fernandes, Daniela ; Guerreiro, Sara; Cunha-Garcia, Daniela; Ferreira-Lomba, Bruna; Pereira Oliveira, Stéphanie; et al.; Maciel Patrícia. Corresponding author: Maciel Patrícia. "Can chronic activation of serotonergic signalling be atherapeutic approach for neurodegenerative diseases?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), 2021.
  8. Oliveira, S; Duarte-Silva, S; Da Silva, J D; Cunha-Garcia, D; Esteves, S; Riess, O; Hübener-Schmid, J; Maciel, P; Teixeira-Castro, A. Corresponding author: Teixeira-Castro, A. "Towards the molecular determinants of serotonergic signaling-mediated suppression of SCA3 pathogenesis"". Paper presented in 8th Ataxia Investigators Meeting (AIM), 2021.
  9. Correia, J.S; Monteiro-Fernandes, D; Guerreiro, S; Lomba, B; Cunha-Garcia, D; Gomes, P; Viana, J; Duarte-Silva, S; Maciel, P. Corresponding author: Maciel, P. "Do MJD mice present a cerebellar cognitive affective syndrome?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), 2021.
  10. Cunha-Garcia, Daniela ; Monteiro-Fernandes, Daniela; Correia, Joana Sofia; Neves-Carvalho, Andreia; Oliveira, João Filipe; Duarte-Silva, S; Maciel, Patrícia. "Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2020.
  11. Cunha-Garcia, Daniela ; Oliveira, João Filipe; Correia, Joana Sofia; Neves-Carvalho, Andreia; Maciel, Patrícia; Duarte-Silva, S. "Impact of astrocytic calcium suppression in the pathogenesis of Machado Joseph disease". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2019.
  12. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Maciel, Patrícia. "Finding molecular determinants supporting serotonergic modulation as a therapeutic approach in Machado Joseph Disease". Paper presented in ICVS Open Day, 2019.
  13. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Maciel, Patrícia; Teixeira-Castro, Andreia. "Early modulation of serotonergic signaling suppresses aggregation in Spinocerebellar Ataxia 3". Paper presented in Workshop on "Strategies & tools for modulating pathologic protein self assembly in proteinopathies", 2019.
  14. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Costa, Maria do Carmo; Teixeira-Castro, Andreia; Maciel, Patrícia. "Preclinical evidence supporting serotonergic modulation as a therapeutic approach for Spinocerebellar Ataxia 3". Paper presented in AD/PD 2019 - The 14th International Conference on Alzheimer's & Parkinson's Diseases, 2019.
  15. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Maciel, Patrícia. "Preclinical evidence supporting early initiation of citalopram treatment in Machado-Joseph disease". Paper presented in ICVS Open Day, 2018.
  16. Oliveira, Stéphanie; Esteves, Sofia; Duarte-Silva, S; Cunha-Garcia, Daniela ; Teixeira-Castro, Andreia; Maciel, Patrícia. "Finding molecular determinants supporting serotonergic modulation as a therapeutic approach in Machado-Joseph disease". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2018.
  17. Oliveira, Stéphanie; Duarte-Silva, S; Esteves, Sofia; Cunha-Garcia, Daniela ; Maciel, Patrícia; Carvalho, A L; Teixeira-Castro, Andreia. "Serotonergic modulation of the proteostasis network and glutamatergic neurotransmission: impact on MJD". Paper presented in Neurosciences annual retreat (ICVS/3B's), 2017.
Journal article
  1. Cunha-Garcia, Daniela ; Monteiro-Fernandes, Daniela; Correia, Joana Sofia; Neves-Carvalho, Andreia; Vilaça-Ferreira, Ana Catarina; Guerra-Gomes, Sónia; Viana, João Filipe; et al. "Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3". International Journal of Molecular Sciences 24 13 (2023): 10606. http://dx.doi.org/10.3390/ijms241310606.
    Published • 10.3390/ijms241310606
  2. Guerra-Gomes, Sónia; Cunha-Garcia, Daniela; Marques Nascimento, Diana Sofia; Duarte-Silva, Sara; Loureiro-Campos, Eduardo; Morais Sardinha, Vanessa; Viana, João Filipe; et al. "IP 3 R2 null mice display a normal acquisition of somatic and neurological development milestones". European Journal of Neuroscience (2020): http://dx.doi.org/10.1111/ejn.14724.
    Published • 10.1111/ejn.14724
  3. Esteves, Sofia; Oliveira, Stéphanie; Duarte-Silva, Sara; Cunha-Garcia, Daniela; Teixeira-Castro, Andreia; Maciel, Patrícia. "Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease". Molecular Neurobiology 56 5 (2018): 3626-3637. http://dx.doi.org/10.1007/s12035-018-1332-1.
    Published • 10.1007/s12035-018-1332-1
Thesis / Dissertation
  1. Cunha-Garcia, Daniela. "Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease". Master, Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, 2021.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/18 Voluntary exercise improves balance and fine motor coordination of a transgenic mouse model of Machado -Joseph disease Sintomas não motores em doenças de Movimento
Neuroscience Portuguese Society (Luso, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/02 - 2021/02/28 Rare Disease Day (2021/02 - 2021/02/28)
Other (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/09/29 - 2023/09/29 The "European Night of Researchers 2023" is an event that occurs across European cities on the last Friday of Setember. The goal is to have researchers from different fields share experiences, their work and knowledge with citizens of all ages. European night of researchers 2023
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Escola de Medicina, Portugal
2019/07 - 2019/07 ICVS Satellite Meeting: Decoding astrocyte-neuron dialogues that produce brain outputs XIV European Meeting on Glial Cells in Health and Disease
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal