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My name is Alexandra Mónica Bastos Viana da Costa. I graduated in Biochemistry from the University of Porto, Faculdade de Ciências in 1989. From 1990 to 1994, I worked at the Parasitology Laboratory at the National Health Institute in Oporto (INSA). In 1994, I was awarded a Marie Curie Fellowship to conduct research at the Pasteur Institute in Lille, France, where I completed my PhD degree in 1998, accredited by USTL, Université de Lille I, France. From 1998 until 2002, I pursued a Post-doctoral FCT fellowship at the Institute Biology of Lille (IBL - France), focusing on leishmaniasis and immune response. Throughout my career, I have contributed to scientific literature, having published 12 articles in renowned journals and authored sections in 1 book. I have been involved in various research projects, participating in 8 different projects as a collaborator, serving as the Principal Investigator in 2 projects, and contributing as a Researcher and Supervisor in others. My expertise lies in the field of Medical and Health Sciences, with a focus on Health Sciences. My key areas include Oral Immunology, Periodontitis, Inflammatory Mediators, Haematological Parameters, and Parasitic Immunology.
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Identification

Personal identification

Full name
Alexandra Mónica Bastos Viana da Costa

Citation names

  • Viana da Costa A.
  • Viana Da Costa A.
  • Da Costa AV
  • da Costa AV

Author identifiers

Ciência ID
3210-404A-63D5
ORCID iD
0000-0003-2245-5316

Email addresses

  • alexandra.costa@iucs.cespu.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
French Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
1998 - 2002
Concluded
 IL-10 role in parasite persistence of Leishmania major infection mouse model (Pós-doutoramento)
Institut de Biologie de Lille, France
1994 - 1998/02/18
Concluded
 University of Lille I - USTL, France (Doktor (PhD))
Major in Health and Life Sciences
Université de Lille Faculté des Sciences et Technologies, France
""L'infection murine par Schistosoma bovis : I - Analyse des Paramètres Parasitaires et Immunologiques ; II - Approche des Mécanismes Protecteurs induits par la S. bovis 28 kDa Glutathion S-transférase" (THESIS/DISSERTATION)
 “Mention Très Honorable”
1989
Concluded
 Biochemistry (Licenciatura)
Major in Fundamental branch
Universidade do Porto Faculdade de Ciências, Portugal
"Candida albicans immunossupressive substances" (THESIS/DISSERTATION)
 12
Affiliation

Science

Category
Host institution 		Employer
1998 - 2002 Postdoc (Research) Institut de Biologie de Lille, France
PInstitut de Biologie de Lille, CNRS 8527, France. , France

Teaching in Higher Education

Category
Host institution 		Employer
2002/09 - 2024/02 Assistant Professor (University Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Other Careers

Category
Host institution 		Employer
1990 - 1994 Assessor Superior (Técnico Superior de Saúde) Instituto Nacional de Saúde Dr. Ricardo Jorge, Porto., Portugal

Others

Category
Host institution 		Employer
1994 - 1998 MARIE CURIE FELLOWSHIP Universidade de Lille I - Sciences and Technology, France, France
Institut Pasteur de Lille, France
Projects

Grant

Designation Funders
1998 - 2002 IL-10 role in parasite persistence in Leishmania major infection mouse model.
FCT
Post-doc
PInstitut de Biologie de Lille, CNRS 8527, France. , France
Concluded
1994 - 1998 Schistosomiasis by S. bovis – Murine Infection and 28GST Vaccine Potential
marie Curie
PhD Student Fellow
Institut Pasteur de Lille, France
Concluded

Contract

Designation Funders
2022/09 - 2023/10 Analysis of inflammatory mediators in the current classification of periodontal diseases: an extra panel os inflammatory activators, half -financed by CESPU AEPIAPD-GI-GI2-CESPU-2022
AEPIAPD-GI-GI2-CESPU-2022
Principal investigator
TOXRUN- Toxicology Research Unit, Portugal
 IUCS/CESPU
Ongoing
2022 - 2023 The association between type 1 diabetes mellitus and periodontal diseases
ADMt1PD
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Not funded
2021/03/15 - 2022/03/31 Analysis of inflammatory mediators in the new classification of periodontal diseases
AMDNCPD_PI2RL_IINFACTS_2021
Co-Investigador (co-responsável)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2016/06/01 - 2018/06/01 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2017 Evaluation of the antiparasitic activity of Nitazoxanide (NTZ)
ActAntiParasitic- iinfacts/CESPU-2016
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
Concluded
2009 - 2012 Influence of conventional periodontal treatment on change the levels of pro-inflammatory markers in saliva and crevicular fluid in subjects with periodontitis
06-GCD-CICS-09¿
Instituto Universitário de Ciências da Saúde, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário CRL
Concluded

Other

Designation Funders
2020/10/15 - 2022/03/07 Avaliação de paramêtros hematológicos e celulares a partir de buffy coats
Interna_IUCS_CESPU_Angola
Supervisor
Instituto Universitário de Ciências da Saúde, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Raman, PG; Gupta, LC. "CAPÍTULO 13 - Resposta imunológica a agentes infeciosos". In Resposta imunológica a agentes infeciosos”, Microbiologia Médica Vol. I, (pg 129-143), 2014, LIDEL, Edições Técnicas, Lisboa., 129-143. Portugal: LIDEL, 2014.
    Published
Conference poster
  1. Costa, Rosana; Alexandra Viana da Costa; BLANCA RÍOS-CARRASCO; Salazar, Filomena; Maria Gonçalves; Relvas, Marta. Corresponding author: Costa, Rosana. "The role of Matrix Metalloproteinase-9 in periodontal disease progression.". Paper presented in SEPA The Spanish Society of Periodontics and Osseointegration, 2023.
  2. S. Aguilera, M. Relvas, A. Viana da Costa. "Metalloproteinases and cellular components in saliva from periodontitis patients: preliminary study.". Paper presented in II TOXRUN International Congress 2023 - Scientific Letters, Volume 1. Supplement 1(2023) ISSN 2795-5117., 2023.
Journal article
  1. Relvas, Marta; Silvestre, Ricardo; Gonçalves, Maria; Cabral, Cristina; Mendes-Frias, Ana; Monteiro, Luís; Viana da Costa, Alexandra. "Analysis of Salivary Levels of IL-1ß, IL17A, OPG and RANK-L in Periodontitis Using the 2017 Classification of Periodontal Diseases An Exploratory Observational Study". Journal of Clinical Medicine 12 3 (2023): 1003. http://dx.doi.org/10.3390/jcm12031003.
    Open access • Published • 10.3390/jcm12031003
  2. Mendes, Leonel Leandro; Costa, Alexandra Mónica Bastos Viana da; Gonçalves, Maria dos Prazeres; Beirão, Maria Fernanda. "RETICULOCYTE COUNT FROM BUFFY COATS: MEDULAR RECOVERY AFTER BLOOD DONATION". International Journal of Health Science 2 58 (2022): 2-13. http://dx.doi.org/10.22533/at.ed.1592582229092.
    Published • 10.22533/at.ed.1592582229092
  3. REIS, CÁTIA; DA COSTA, ALEXANDRA VIANA; GUIMARÃES, JOÃO TIAGO; TUNA, DIANA; BRAGA, ANA CRISTINA; PACHECO, JOSÉ JULIO; AROSA, FERNANDO A.; SALAZAR, FILOMENA; CARDOSO, ELSA MARIA. "Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6". Exp Ther Med. 2014 Jul;8(1):323-327 (2014): http://dx.doi.org/10.3892/etm.2014.1724.
  4. Correia, Margareta P.; Costa, Alexandra V.; Uhrberg, Markus; Cardoso, Elsa M.; Arosa, Fernando A.. "IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion". Immunobiology. 2011 May;216(5):604-12. 216 5 (2011): 604-612. http://dx.doi.org/10.1016/j.imbio.2010.09.012.
    Published
  5. Almeida, André; Moreira, Maria João; Soares, Sónia; Delgado, Maria de Lurdes; Figueiredo, João; Magalhães, Elisabete Silva; Castro, António; Viana Da Costa, Alexandra; Correia da Costa, José Manuel. "Biological and Genetic Characterization of Cryptosporidium spp. and Giardia duodenalis Isolates from Five Hydrographical Basins in Northern Portugal". The Korean Journal of Parasitology 48 2 (2010): 105. http://dx.doi.org/10.3347/kjp.2010.48.2.105.
    10.3347/kjp.2010.48.2.105
  6. Viana da Costa, Alexandra; Huerre, Michel; Delacre, Myriam; Auriault, Claude; Manuel Correia Costa, José; Verwaerde, Claudie. "IL-10 leads to a higher parasite persistence in a resistant mouse model of Leishmania major infection". Parasitology International 51 4 (2002): 367-379. http://dx.doi.org/10.1016/s1383-5769(02)00039-9.
    10.1016/s1383-5769(02)00039-9
  7. DE KOZAK, Y.; THILLAYE-GOLDENBERG, B.; NAUD, M.-C.; DA COSTA, A. VIANA; AURIAULT, C.; VERWAERDE, C.. "Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene". Clinical and Experimental Immunology 130 2 (2002): 212-223. http://dx.doi.org/10.1046/j.1365-2249.2002.01969.x.
    10.1046/j.1365-2249.2002.01969.x
  8. VIANA DA COSTA, ALEXANDRA; GAUBERT, SOPHIE; LAFITTE, SOPHIA; FONTAINE, JOSETTE; CAPRON, ANDRE; GRZYCH, JEAN-MARIE. "Egg-hatching inhibition in mice immunized with recombinant Schistosoma bovis 28 kDa glutathione S-transferase". Parasite Immunology 21 7 (1999): 341-350. 10.1046/j.1365-3024.1999.00232.x..
    10.1046/j.1365-3024.1999.00232.x
  9. GAUBERT, SOPHIE. "X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model". Parasite Immunology 21 2 (1999): 89. http://dx.doi.org/10.1046/j.1365-3024.1999.00205.x.
    10.1046/j.1365-3024.1999.00205.x
  10. DA COSTA, ALEXANDRA VIANA; LAFITTE, SOPHIA; FONTAINE, JOSETTE; BOSSUS, MARC; GRAS-MASSE, HELENE; CAPRON, ANDRE; GRZYCH, JEAN-MARIE. "Definition and mapping of epitopes recognized by specific monoclonal antibodies to Schistosoma bovis 28 kDa glutathione S-transferase: relation with anti-egg viability immunity". Parasite Immunology 21 1 (1999): 9-18. 10.1046/j.1365-3024.1999.00196.x.
    10.1046/j.1365-3024.1999.00196.x
  11. VIANA da COSTA, ALEXANDRA; GAUBERT, SOPHIE; FONTAINE, JOSETTE; LAFITTE, SOPHIA; SEIXAS, ANTONIO; DE LOURDES SAMPAIO SILVA, MARIA; CAPRON, ANDRÉ; GRZYCH, JEAN-MARIE. "MurineSchistosoma bovisinfection: analysis of parasitic and immune parameters". Parasite Immunology 20 3 (1998): 143-153. 10.1046/j.1365-3024.1998.00136.x.
    10.1046/j.1365-3024.1998.00136.x
  12. Silva, M. L. Sampaio; Monjour, L.; da Costa, J. M. Correia; Pires, M. A.; da Costa, A. M. Viana; Castro, A. M.; Lopes, S. A.. "Antigenic Components of Excretory-Secretory Products of Adult Fasciola hepatica Recognized in Human Infections". The American Journal of Tropical Medicine and Hygiene 54 2 (1996): 146-148. http://dx.doi.org/10.4269/ajtmh.1996.54.146.
    10.4269/ajtmh.1996.54.146
Activities

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current 1600-0579 (1600-0579) John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Mentoring / Tutoring

Topic Student name
2023/11 - 2024 Quantification of the cytokine IL-17A in the saliva of patients with gingivitis and periodontitis. License of Biomedical Sciences Marta Pereira
2022/10 - 2023/07 Analysis, in saliva, of MMP-8 levels and relationship with leukocyte populations of patients with periodontitis. (Análise, na saliva, dos níveis de MMP-8 e relação com as populações de leucócitos de doentes com periodontite). License Biomedical Sciences Sofia Bordón Aguilera
2021/10 - 2022/06 Saliva: relevant physiological fluid in the current classification of periodontal diseases? (Saliva: fluido fisiológico relevante na atual classificação Co-orientation student of 5th year at Master's Degree Dissertation in Dentistry (Integrated Cycle). Marta Filipa Silva Mesquita
2021/10 - 2022/06 GCF and its inflammatory mediators in the current classification of periodontal diseases. (GCF e seus mediadores inflamatórios na classificação atual das doenças periodontais.) Co-orientation student at Master's Degree Dissertation in Dentistry (5th yea Ana Helena Albuquerque Mota Vieira Borges
2021/10 - 2022 Orientation of a Master degree student (Master Forensic Laboratory Science & Techniques/ MCTLF) Leonel Leandro Mendes