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Ana Raquel Neves completed the bachelor¿s degree in Biochemistry in 2017 and master¿s in biotechnology in 2019 at the University of Beira Interior (Covilhã ¿ Portugal). Is currently doing the Ph.D. in Biomedicine since 2019 in CICS-UBI - Health Sciences Research Centre at the University of Beira Interior in collaboration with the Department of Biology & CESAM at University of Aveiro, the Cancer Research Centre at the University of Salamanca and the Engineering Research Institute of Aragon (I3A) at the University of Zaragoza. At a scientific level, her main research activity is related with the development of co-delivery systems for cancer gene therapy. Ana R. Neves works since her master¿s project with peptide-based systems to treat cervical and glioblastoma cancer. Her Ph.D. his supported by a FCT (Foundation for Science and Technology) doctoral fellowship since 2021. She counts with several chapters, reviews and original papers published and experienced laboratory students supervision and Biotechnology and Biomaterials practical classes teaching.
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Identification

Personal identification

Full name
Ana Raquel Bastos Neves

Citation names

  • Ana R. Neves
  • AR. Neves

Author identifiers

Ciência ID
301B-EB19-CE0C
ORCID iD
0000-0003-3170-0977

Email addresses

  • ana.neves@ubi.pt (Professional)
  • ana_raquel_bastos_neves@hotmail.com (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2019 - 2024
Ongoing
 Biomedicine (Faculty of Health Sciences) (Doutoramento)
Universidade da Beira Interior, Portugal
2017 - 2019
Concluded
 Biotechnology (Faculty of Sciences) (Mestrado)
Universidade da Beira Interior, Portugal
"Cancer gene therapy: design, development and in vitro evaluation of a plasmid DNA delivery system" (THESIS/DISSERTATION)
 17
2014 - 2017
Concluded
 Biochemistry (Faculty of Sciences) (Licenciatura)
Universidade da Beira Interior, Portugal
"Glucides derivatives for cystic fibrosis treatment " (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2019/07 - Current Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/10 - 2023/12 Visiting Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidad de Zaragoza - Campus Río Ebro, Spain
2023/05 - 2023/07 Visiting Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
2023/01/18 - 2023/01/20 Visiting Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidad de Zaragoza - Campus Río Ebro, Spain
2022/05/01 - 2022/05/31 Visiting Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidad de Salamanca - Campus Miguel de Unamuno, Spain
2018/07 - 2019/06 Research Trainee (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2021/01 - Current The bridge between Nanotechnology and Chronobiology: Circadian control of Cancer Therapy by Raman nanosensors
2020.08310.BD
PhD Student Fellow
Universidade da Beira Interior, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/02 - 2020/12 Gene Therapy for Glioblastoma: Nanobiotechnology-based strategies for targeted delivery
BID/FCS/2019
PhD Student Fellow
Universidade da Beira Interior, Portugal
 Banco Santander Portugal
Concluded
Outputs

Publications

Book chapter
  1. AR. Neves; Albuquerque, Tânia; Biswas, Swati; Costa, Diana Rita Barata. Corresponding author: Costa, Diana Rita Barata. "Calcium phosphate nanoparticles in therapeutics". In Inorganic Nanosystems, 407-435. Elsevier, 2023.
    Published • 10.1016/b978-0-323-85784-0.00005-4
  2. AR. Neves; Biswas, Swati; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Nanoconjugates and nanoconjugate formulations for improving drug delivery and therapeutic efficacy". In Advanced Nanoformulations, 397-430. Elsevier, 2023.
    Published • 10.1016/b978-0-323-85785-7.00020-6
  3. AR. Neves; Faria, Rúben; Biswas, Swati; Costa, Diana. Corresponding author: Costa, Diana. "Plant polysaccharides in formulation coating". In Plant Polysaccharides as Pharmaceutical Excipients, 391-413. Elsevier, 2023.
    Published • 10.1016/b978-0-323-90780-4.00010-3
  4. Ana R. Neves; Albuquerque, Tânia; Eusébio, Dalinda; Sousa, Ângela; Costa, Diana. "Challenges and future perspectives of natural biopolymers in drug delivery". In Natural Biopolymers for Drug Delivery. Elsevier, 2023.
    Submitted
  5. AR. Neves; Faria, Rúben; Albuquerque, Tânia; Quintela, Telma; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Future perspectives of biological macromolecules in biomedicine". In Biological Macromolecules, 607-632. Elsevier, 2022.
    Published • 10.1016/b978-0-323-85759-8.00026-9
  6. Albuquerque, Tânia; AR. Neves; Faria, Rúben; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Chronobiology and Nanotechnology for Personalized Cancer Therapy". In Cancer Nanotechnology, 205-227. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-17831-3_7
  7. Faria, Rúben; Albuquerque, Tânia; AR. Neves; Sousa, Ângela; Costa, Diana Rita Barata. Corresponding author: Costa, Diana Rita Barata. "Nanotechnology to Correct Mitochondrial Disorders in Cancer Diseases". In Cancer Nanotechnology, 179-203. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-17831-3_6
  8. AR. Neves. "Drug delivery for bone tissue engineering". In Advanced and Modern Approaches for Drug Delivery. Elsevier, 2022.
    In press
  9. AR. Neves. "Bio-inspired drug delivery therapeutics". In Recent and Future Trends in Pharmaceutics. Elsevier, 2022.
    Under revision
  10. Costa, Diana; Sousa, Ângela; Faria, Rúben; AR. Neves; Queiroz, João A.. Corresponding author: Queiroz, João A.. "Conception of Plasmid DNA and Polyethylenimine Delivery Systems with Potential Application in DNA Vaccines Field". In Methods in Molecular Biology, 271-284. Springer US, 2021.
    Published • 10.1007/978-1-0716-0872-2_15
Conference poster
  1. AR. Neves. "Transferrin-peptide-based complexes for dual drug/gene delivery towards glioblastoma". Paper presented in Ciência 2023, 2023.
  2. Ana R. Neves. "Glioblastoma therapy: development of WRAP5-based nanosytems for targeted drug/gene co-delivery". Paper presented in XVII ANNUAL CICS-UBI SYMPOSIUM 2022, 2022.
  3. Ana R. Neves. "Innovative WRAP5 peptide-based nanocomplexes for targeted TMZ/p53 co-delivery for glioblastoma treatment". Paper presented in Encontro Ciência 2022, 2022.
  4. Neves, Ana. "RALA/plasmid DNA nanoparticles: a promising gene therapy for cancer". Paper presented in III International Congress in Health Sciences Research Towards Innovation and Entrepreneurship: Trends in Aging and Cancer, 2019.
Journal article
  1. Neves, Ana. "Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells". Pharmaceutics 16 6 (2024): https://www.mdpi.com/1999-4923/16/6/781.
    Published
  2. AR. Neves. "The Role of Biological Rhythms in New Drug Formulations to Cross the Brain Barriers". International Journal of Molecular Sciences 24 16 (2023): https://www.mdpi.com/1422-0067/24/16/12541.
    Published
  3. AR. Neves. "A Potential Effect of Circadian Rhythm in the Delivery/Therapeutic Performance of Paclitaxel–Dendrimer Nanosystems". Journal of Functional Biomaterials 14 7 (2023): 362. https://www.mdpi.com/2079-4983/14/7/362.
    Published
  4. AR. Neves; Albuquerque, Tânia; Faria, Rúben; Gonçalves, Ana M.; Santos, Cecília; Vivès, Eric; Boisguérin, Prisca; et al. Corresponding author: Costa, Diana. "Development of WRAP5 Peptide Complexes for Targeted Drug/Gene Co-Delivery toward Glioblastoma Therapy". Pharmaceutics 14 10 (2022): 2213. http://dx.doi.org/10.3390/pharmaceutics14102213.
    Published • 10.3390/pharmaceutics14102213
  5. AR. Neves; Albuquerque, Tânia; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Circadian rhythm and disease: Relationship, new insights, and future perspectives". Journal of Cellular Physiology 237 8 (2022): 3239-3256. http://dx.doi.org/10.1002/jcp.30815.
    Published • 10.1002/jcp.30815
  6. Albuquerque, Tânia; AR. Neves; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector". Polymers 14 4 (2022): 681. http://dx.doi.org/10.3390/polym14040681.
    Published • 10.3390/polym14040681
  7. Eusébio, Dalinda; AR. Neves; Costa, Diana; Biswas, Swati; Alves, Gilberto; Cui, Zhengrong; Sousa, Ângela. Corresponding author: Sousa, Ângela. "Methods to improve the immunogenicity of plasmid DNA vaccines". Drug Discovery Today 26 11 (2021): 2575-2592. http://dx.doi.org/10.1016/j.drudis.2021.06.008.
    Published • 10.1016/j.drudis.2021.06.008
  8. AR. Neves; Albuquerque, Tânia; Faria, Rúben; Paul, Milan; Biswas, Swati; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Development of Tailor-Made Dendrimer Ternary Complexes for Drug/Gene Co-Delivery in Cancer". Pharmaceutics 13 8 (2021): 1256. http://dx.doi.org/10.3390/pharmaceutics13081256.
    Published • 10.3390/pharmaceutics13081256
  9. Albuquerque, Tânia; AR. Neves; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Exploring the link between chronobiology and drug delivery: effects on cancer therapy". Journal of Molecular Medicine 99 10 (2021): 1349-1371. http://dx.doi.org/10.1007/s00109-021-02106-x.
    Published • 10.1007/s00109-021-02106-x
  10. Serra, Ana Sofia; Eusébio, Dalinda; AR. Neves; Albuquerque, Tânia; Bhatt, Himanshu; Biswas, Swati; Costa, Diana; Sousa, Ângela. Corresponding author: Sousa, Ângela. "Synthesis and Characterization of Mannosylated Formulations to Deliver a Minicircle DNA Vaccine". Pharmaceutics 13 5 (2021): 673. http://dx.doi.org/10.3390/pharmaceutics13050673.
    Published • 10.3390/pharmaceutics13050673
  11. Faria, Rúben; Albuquerque, Tânia; AR. Neves; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana. Corresponding author: Costa, Diana. "Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes". Journal of Molecular Liquids 316 (2020): 113873. http://dx.doi.org/10.1016/j.molliq.2020.113873.
    Published • 10.1016/j.molliq.2020.113873
  12. Albuquerque, Tânia; Faria, Rúben; Sousa, Ângela; AR. Neves; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Polymer-peptide ternary systems as a tool to improve the properties of plasmid DNA vectors in gene delivery". Journal of Molecular Liquids 309 (2020): 113157. http://dx.doi.org/10.1016/j.molliq.2020.113157.
    Published • 10.1016/j.molliq.2020.113157
  13. AR. Neves; Sousa, A.; Faria, R.; Albuquerque, T.; Queiroz, J.A.; Costa, D.. Corresponding author: Costa, D.. "Cancer gene therapy mediated by RALA/plasmid DNA vectors: Nitrogen to phosphate groups ratio (N/P) as a tool for tunable transfection efficiency and apoptosis". Colloids and Surfaces B: Biointerfaces 185 (2020): 110610. http://dx.doi.org/10.1016/j.colsurfb.2019.110610.
    Published • 10.1016/j.colsurfb.2019.110610
  14. Faria, Rúben; Sousa, Ângela; AR. Neves; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Methotrexate-plasmid DNA polyplexes for cancer therapy: Characterization, cancer cell targeting ability and tuned in vitro transfection". Journal of Molecular Liquids 292 (2019): 111391. http://dx.doi.org/10.1016/j.molliq.2019.111391.
    Published • 10.1016/j.molliq.2019.111391
Thesis / Dissertation
  1. Neves, Ana. "Neves, AR. 2019. "Cancer gene therapy: design, development and in vitro evaluation of a plasmid DNA delivery system"". Master, Universidade da Beira Interior, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/11 Peptides-nanoparticles for glioblastoma targeting and therapy XVIII International CICS-UBI Symposium 2023
(Covilhã, Portugal)
2021/09/30 Ternary dendrimer complexes for drug/gene co-delivery in cancer XVI ANNUAL CICS-UBI SYMPOSIUM 2021
(Covilhã, Portugal)
2020/11/26 Therapeutic vaccines in cancer: nanotechnology & chronobiology "3 Minutos, 1 Slide, A tua tese"
(Covilhã, Portugal)
2020/10/01 Cancer gene therapy mediated by RALA/Plasmid DNA delivery systems XV ANNUAL CICS-UBI SYMPOSIUM 2020
Faculty of Health Sciencs (Covilhã, Portugal)
2019/07 Cancer gene therapy: design, development and in vitro evaluation of a RALA peptide/pDNA vector XIV ANNUAL CICS-UBI SYMPOSIUM 2019
Faculdade de Ciências da Saúde, UBI (Covilhã, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022 - 2023 IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics (2023/02/12 - 2023/02/15)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019/11 - 2019/11 Science & Technology 2019 Week - CICS-UBI Game Lab (2019/11/26 - 2019/11/26) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03/21 - Current DNA Fingerprinting Workshop
Meeting
 National meeting of Biomedical Sciences 2024
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018/07 - 2018/07 XIII Annual CICS-UBI Symposium 2018
Symposium
 XIII Annual CICS-UBI Symposium 2018
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2018 IV ENEBT - Biotechnology Students National Meeting, Covilhã
Meeting
 IV ENEBT - Biotechnology Students National Meeting, Covilhã
Universidade da Beira Interior Faculdade de Ciências, Portugal
2016 - 2016 IV Chemistry Students National Meeting (ENEQUI), Porto
Meeting
 IV Chemistry Students National Meeting (ENEQUI), Porto
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016 IV Chemistry and Biochemistry Journeys, Covilhã
Congress
 IV Chemistry and Biochemistry Journeys, Covilhã
Universidade da Beira Interior Faculdade de Ciências, Portugal
2015 - 2015 III Chemistry Students National Meeting (ENEQUI), Aveiro
Meeting
 III Chemistry Students National Meeting (ENEQUI), Aveiro
Universidade de Aveiro, Portugal
2015 - 2015 III Chemistry and Biochemistry Journeys, Covilhã
Congress
 III Chemistry and Biochemistry Journeys, Covilhã
Universidade da Beira Interior Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2021 - 2023/04 CAD-CICS-UBI: PhD Student Committee (CAD) of The Health Sciences Research Centre of University (CICS) of Beira Interior (UBI) Association member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/03/14 - Current Advanced DNA Vaccine Course (Lab: 4h) (Mestrado) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2024/04/04 - 2024/05/09 Courses: Biomedical Sciences, Biochemistry, Bioengineering and Biotechnology (Lab: 12h) Biomaterials (Licenciatura) Universidade da Beira Interior, Portugal
2023/05/02 - 2023/05/05 Courses: Biomedical Sciences, Biochemistry, and Biotechnology Biomaterials Universidade da Beira Interior, Portugal
2022/05 - 2022/05 Courses: Biomedical Sciences, Biochemistry, Bioengineering and Biotechnology Biomaterials Universidade da Beira Interior, Portugal
2020/11 - 2020/12 Courses: Biomedical Sciences, Biochemistry, Industrial Chemistry and Bioengineering (Lab: 60h) Pharmaceutic Biotechnology Universidade da Beira Interior, Portugal
2018 - 2018 Young Researchers Course (CICS-UBI), Covilhã (Outros) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2024/03 - 2024/04 Seminar Luísa Inês Mendes/Constança Da Conceição Pinto Barroso
2024/02/26 - 2024/03/01 Voluntary internship block of introduction to research, 3rd in the integrated masters in Medicine Camila Sá Coutinho Lapa
2023/04 - 2023/05 Seminar Lara Paiva / Ana Meirinhos
Distinctions

Award

2020 "3 minutos, 1 slide .... A Tua tese!" - 5th place
Banco Santander Portugal, Portugal

Universidade da Beira Interior, Portugal
2020 Merit Scholarship, 2018/2019