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From 2014 to 2017 she completed her bachelor's degree in Biochemistry, at the University of Minho. At the end of that year, she was integrated as a Research Trainee at the Life and Health Sciences Research Institute (ICVS) in a project to explore the relevance of adult hippocampal cytogenesis (neurogenesis and gliogenesis) in rat behavior and the function of female hormones in the context of depression (Cell Proliferation, doi: 10.1111/cpr.13165). After this period, in 2018, she enrolled in the ICVS/School of Medicine Master's degree in Health Sciences, with specialization in neurosciences. Her master's project was dedicated to unveil how adult cytogenesis impacts brain activity, in the context of mood disorders. In fact, during her master thesis, she explored the role of glial restricted precursor (GRP) cells, when transplanted into the brain dorsal dentate gyrus of the hippocampi, in a rodent model of cytogenesis impairments (GFAP-tk), a work whose results were recently accepted for publication in Molecular Psychiatry. In this regard, this work is one of the first to demonstrate a valuable and specific contribution of glial progenitors to accelerate not only the regulation of gliogenic levels, but also the rescue of neurogenesis, and importantly, the recovery of behavioral deficits intrinsic to mood disorders, such as depression. In addition, she has also been involved in multiple research teams/projects successfully funded, which have been creating a strong impact in the field of neuroscience, from which she was able to publish a total of nine papers in peer-reviewed journals (Molecular Psychiatry, Cell Proliferation, Antioxidants, Cells, Glia, Neuroscience and Biobehavioral Reviews, and Frontiers in Bioengineering and Biotechnology), four of them as first-author (two literature reviews and two results papers) in important journals of the respective fields, presenting a total accumulated impact factor of 74.952 (IF= 8.328/paper). To complement her publication record, she was invited to be guest editor of a special methods collection at JoVE (https://www.jove.com/methods-collections/809). Since early on, she has been involved in projects outside academia, working at a University of Minho start-up company "BnML" as a research associate, and then as a full-time project manager, getting in contact with clients and presenting the work developed under BnML context in conferences from the biotechnology/biomedicine field. During this period, she was also able to participate in the development and validation of an automated stress equipment, to be used for preclinical research, among neuroscience fields, which led to her first results paper (Cells, doi: 10.3390/cells12030381). Importantly, she supervised three students, one in the context of a bachelor's scientific project and two in the context of BnML's summer Internships. In addition to several other courses (Management and Bio-Entrepreneurship, Clinical Trials and Animal Models Experiments' certifications, Data Analysis and Business Intelligence), since 2021 up to 2023, she worked as a tax consultant, in funding advisory for R&D, innovation and sustainability incentives at Ernst & Young (EY). Specifically, it is important to highlight that this experience provided her skills on advisory services, regarding the application of R&D projects from consortia including academic and non-academic institutions to European Commission calls, as well as to fiscal and financial incentives from the Portuguese government. In July 2023, she won a PhD scholarship from FCT "2023.00893.BDANA", in the non-academic context, where she is currently developing her PhD project entitled "Does adult hippocampal gliogenesis modulate non-motor symptoms of PD? Understanding the role of newly-born glial cells in PD progression.".
Identification

Personal identification

Full name
Joana Catarina Martins Macedo

Citation names

  • Martins-Macedo, J

Author identifiers

Ciência ID
3010-9A37-C1FA
ORCID iD
0000-0003-0442-927X

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2023/12 - 2027/12
Ongoing
PhD in Neurosciences (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Bn'ML - Behavioral & Molecular Lab, Portugal

TBIO - Center for Translational Health & Medical Biotechnology, Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2024/10 - 2025/06
Ongoing
Post-Graduation in Data Analysis for Business (Pós-Graduação)
Instituto Politécnico do Cávado e do Ave, Portugal
2025/02/03 - 2025/02/06
Ongoing
Introduction to Python and Machine Learning for the Biosciences | 9th Edition (Outros)
Major in Advanced Course
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/11 - 2024/12
Concluded
Research Project Management, 4th edition (Outros)
Major in Advanced Course
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/04/04 - 2024/04/05
Concluded
Advanced Course: 4th Workshop on Neuroengineering: brain-on-a-chip platforms and Hands-on practical session: "Imaging neuronal activity with Calcium dyes" (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/08/01 - 2021/08/01
Concluded
ICH Good Clinical Practice E6 (R2) (Diploma de especialização)
The Global Health Network, France
2021/07/01 - 2021/07/31
Concluded
Master in Innovation Management (Outros)
ANJE Associação Nacional de Jovens Empresários, Portugal
2021/07/01 - 2021/07/31
Concluded
Data Analysis and Business Intelligence (Outros)
TecMinho Associação Universidade-Empresa para o Desenvolvimento, Portugal
2021/07/01 - 2021/07/31
Concluded
Excel - Visual Basic Applications Programming (Outros)
Galileu - Focus on Success, Portugal
2021/04 - 2021/04
Concluded
Digital Content Management Course (Outros)
ANJE Associação Nacional de Jovens Empresários, Portugal
2021/03 - 2021/03
Concluded
Digital Marketing Course (Outros)
ANJE Associação Nacional de Jovens Empresários, Portugal
2020/11 - 2020/12
Concluded
Advanced Course in Clinical Trials (Outros)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/09 - 2020/09
Concluded
Health Sciences (Mestrado)
Major in Neurociências
Universidade do Minho, Portugal
"Transplanting Glial Restricted Precursors into a model of cytogenesis ablation: Uncovering the interplay between neuro- and gliogenesis " (THESIS/DISSERTATION)
2019/11/04 - 2020/01/22
Concluded
Management of SMEs Course (Outros)
Major in Gestão de Empresas
TecMinho Associação Universidade-Empresa para o Desenvolvimento, Portugal
2019/01/28 - 2019/02/08
Concluded
Labortory Animal Science Course (Outros)
Major in FELASA categoria C para experimentação animal
Universidade do Minho, Portugal
2018/04 - 2018/04
Concluded
Advanced Course: Being a Bio-Entrepreneur (Outros)
Major in Bio-Empreededorismo
Universidade do Minho, Portugal
2018/03 - 2018/04
Concluded
Project Management Course (Outros)
Major in Gestão
TecMinho Associação Universidade-Empresa para o Desenvolvimento, Portugal
2014/09 - 2017/07
Concluded
Biochemistry (Licenciatura)
Universidade do Minho, Portugal
Affiliation

Science

Category
Host institution
Employer
2019 - 2021 Science and Technology Management BnML Behavioral and Molecular Lab Lda, Portugal
BnML Behavioral and Molecular Lab Lda, Portugal
2017 - 2018 Research Trainee (Research) BnML Behavioral and Molecular Lab Lda, Portugal
BnML Behavioral and Molecular Lab Lda, Portugal
2017/07 - 2017/11 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Others

Category
Host institution
Employer
2023/12 - 2027/12 PhD student in Neurosciences Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
(...)
2021/09 - 2023/09 Consultant | Tax - Funding Advisory for R&D, Innovation and Sustainability Incentives Ernst & Young Portugal, Portugal
Ernst & Young Portugal, Portugal
Projects

Grant

Designation Funders
2022 - Current Hippocampal connectivity and behavioral performance in health and depression: where does adult astrogliogenesis stand?
2022.02201.PTDC
Researcher
Laboratório Associado ICVS 3B's, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - Current SynChronize – Focused Ultrasound combined with Stem Cells Secretome and Pharmacotherapies: establishing a Multimodal path for Parkinson’s Disease repair
SynChronize
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Santa Casa da Misericórdia de Lisboa
Ongoing
2019 - Current Impact of adult astrogliogenesis in the brain
ID 11641
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Nature's Own Research Association
Ongoing
2024/01/02 - 2025/06/30 Será o Oxigénio juntamente com antidepressivos multimodais um caminho para mitigar a progressão e deterioração da doença de Parkinson?
2023.14158.PEX
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/05/01 - 2025/04/30 Mechanisms of action and resistance to the antimalarial Purydrazide
PTDC/SAU-PAR/2766/2021
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2017 - 2021 Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
721236
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2017 - 2020 Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
427/14
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação Bial
Concluded
2017 - 2019 Predicting the effects of antidepressants in the recovery, remission and relapse of depression: a novel multimodal approach
PTDC/DTP-PIC/6936/2014
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Rita Caridade-Silva; Bruna Araújo; Martins-Macedo, J; Benoit Larrat; Sébastien Mériaux; Fábio Teixeira. "IMPACT OF N-ACETYLCYSTEINE ON PARKINSON’S DISEASE FUNCTIONAL CONNECTOMICS: A FRIEND OR FOE?". 2023.
    10.1016/J.IBNEUR.2023.08.715
  2. Bruna Araújo; Martins-Macedo, J; Tiago Silveira-Rosa; Francisco Soares Neves; Patrícia Patrício; Eduardo Loureiro-Campos; Rita Caridade-Silva; et al. "HILUS, A NEW CYTOGENIC HIPPOCAMPAL NICHE MODULATED BY STRESS EXPOSURE AND TREATMENT WITH ANTIDEPRESSANTS". 2023.
    10.1016/J.IBNEUR.2023.08.1042
  3. Bruna Araújo; Jonas Campos; Rita Caridade-Silva; Bárbara Mendes-Pinheiro; Raquel Marques; Sandra Barata; Rui Lima; et al. "MODULATION OF BRAIN CONNECTIVITY, STRUCTURE, NEURON AND GLIA, AND MOTOR FUNCTION BY SAFINAMIDE MULTIMODAL ACTIONS IN A PRE-CLINICAL MODEL OF PARKINSON’S DISEASE". 2023.
    10.1016/J.IBNEUR.2023.08.337
  4. Martins-Macedo, Joana. "Transplanting GRPs Into an Animal Model of Cytogenesis Ablation: Uncovering the Interplay Between Neuro and Gliogenesis". Paper presented in JRC Summer School on Non-Animal Approaches in Science - The Three R…evolution, 2021.
  5. Rodrigues-Neves, A; Gaspar, Rita; Patrício, P; Lima, Susana; Silveira-Rosa, T; Martins-Macedo, J; Araújo, B.; et al. "Microglia, a key element in schizophrenia pathophysiology: insights from an animal model". Paper presented in EMBO Workshop Microglia 2020 - EMBL Heidelberg, Germany, 2020.
  6. Silveira-Rosa, T; Patrício, P; Mateus-Pinheiro, A; Araújo, B.; Martins-Macedo, J; Loureiro-Campos, E; Lima, Susana; et al. "Circuitry and connectivity of hippocampal neurons in the context of depression and antidepressant treatment". Paper presented in XIII NeRD retreat, Guimarães, Portugal, 2019.
  7. Lima, Susana; Patrício, P; Silveira-Rosa, T; Araújo, B.; Martins-Macedo, J; Pinto, Luisa. "The impact of reproductive experience in females on the susceptibility and treatment of depressive-like behavior with allopregnanolone". Paper presented in XIII NeRD retreat 2019, Guimarães, Portugal, 2019.
Journal article
  1. Catarina Teixeira; Joana Martins-Macedo; Eduardo Gomes; Carla Soares-Guedes; Rita Caridade-Silva; Bruna Araújo; Cristiana Vilela; et al. "From peripheral to central (Neuro)degeneration: Is heart-kidney a new axial paradigm for Parkinson’s disease?". Brain Organoid and Systems Neuroscience Journal (2024): https://doi.org/10.1016/j.bosn.2024.11.003.
    10.1016/j.bosn.2024.11.003
  2. Joana Martins-Macedo; Eduardo D. Gomes; João F. Oliveira; Patrícia Patrício; Luísa Pinto. "StressMatic: Bridging Innovation and Reliability in Animal Models of Stress". Brain Organoid and Systems Neuroscience Journal (2024): https://doi.org/10.1016/j.bosn.2024.11.002.
    10.1016/j.bosn.2024.11.002
  3. Cristiana Vilela; Bruna Araújo; Carla Soares-Guedes; Rita Caridade-Silva; Joana Martins-Macedo; Catarina Teixeira; Eduardo D. Gomes; et al. "From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment?". Cells (2024): https://doi.org/10.3390/cells13090770.
    10.3390/cells13090770
  4. Martins-Macedo, J; Bruna Araújo; Sandra I. Anjo; Tiago Silveira-Rosa; Patrícia Patrício; Nuno Dinis Alves; Joana M. Silva; et al. "Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation". Molecular Psychiatry (2024): https://doi.org/10.1038/s41380-024-02490-z.
    10.1038/s41380-024-02490-z
  5. Vilela, Cristiana; Araújo, Bruna; Soares-Guedes, Carla; Caridade-Silva, Rita; Martins-Macedo, J; Teixeira, Catarina; Gomes, Eduardo D.; et al. Corresponding author: Teixeira, Fábio G. "From the Gut to the Brain: Is microbiome a new paradigm in Parkinson’s Disease Treatment?". Cells (2024):
    Accepted
  6. Rita Caridade-Silva; Bruna Araújo; Martins-Macedo, J; Fábio G. Teixeira. "N-Acetylcysteine Treatment May Compensate Motor Impairments through Dopaminergic Transmission Modulation in a Striatal 6-Hydroxydopamine Parkinson’s Disease Rat Model". Antioxidants (2023): https://doi.org/10.3390/antiox12061257.
    10.3390/antiox12061257
  7. Martins-Macedo, Joana; António Mateus-Pinheiro; Cátia Alves; Fernando Veloso; Eduardo D. Gomes; Inês Ribeiro; Joana S. Correia; et al. "StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats". Cells (2023): https://doi.org/10.3390/cells12030381.
    10.3390/cells12030381
  8. Bruna Araújo; Rita Caridade-Silva; Carla Soares-Guedes; Joana Martins-Macedo; Eduardo D. Gomes; Susana Monteiro; Fábio G. Teixeira. "Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities". Cells (2022): https://doi.org/10.3390/cells11182908.
    10.3390/cells11182908
  9. Silveira-Rosa, Tiago; Mateus-Pinheiro, António; Correia, Joana Sofia; Silva, Joana Margarida; Martins-Macedo, Joana; Araújo, Bruna; Machado-Santos, Ana Rita; et al. "Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity". Cell Proliferation 55 2 (2021): http://dx.doi.org/10.1111/cpr.13165.
    Published • 10.1111/cpr.13165
  10. Joana Martins-Macedo; António J. Salgado; Eduardo D. Gomes; Luísa Pinto. "Adult brain cytogenesis in the context of mood disorders: From neurogenesis to the emergent role of gliogenesis". Neuroscience & Biobehavioral Reviews 131 (2021): 411-428. https://doi.org/10.1016/j.neubiorev.2021.09.030.
    10.1016/j.neubiorev.2021.09.030
  11. Mateus-Pinheiro, António; Patrício, Patrícia; Alves, Nuno Dinis; Martins-Macedo, Joana; Caetano, Inês; Silveira-Rosa, Tiago; Araújo, Bruna; et al. "Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits". Molecular Psychiatry 26 12 (2021): 7154-7166. http://dx.doi.org/10.1038/s41380-021-01287-8.
    Published • 10.1038/s41380-021-01287-8
  12. Landesmann, Brigitte; Paini, Alicia. "JRC Summer School on Non-animal Approaches in Science, May 2021 Preface". Alternatives to Laboratory Animals (2021): https://publons.com/wos-op/publon/55057579/.
    10.1177/02611929211065919
  13. Martins-Macedo, Joana; Lepore, Angelo C.; Domingues, Helena S.; Salgado, António J.; Gomes, Eduardo D.; Pinto, Luísa. "Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives". Glia (2020): http://dx.doi.org/10.1002/glia.23922.
    Accepted • 10.1002/glia.23922
  14. Gomes, Eduardo D.; Ghosh, Biswarup; Lima, Rui; Goulão, Miguel; Moreira-Gomes, Tiago; Martins-Macedo, Joana; Urban, Mark W.; et al. "Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00984.
    Accepted • 10.3389/fbioe.2020.00984
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/05 Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation 8th Symposium of the Portuguese Glial Network, 2024, Braga, Portugal
Portuguese Glial Network (Braga, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019/06 - 2019/09 BnML Summer Internship
Supervisor
Summer Internship (Other)
BnML Behavioral and Molecular Lab Lda, Portugal
2019/04 - 2019/07 Cell culture and engraftment of glial-restricted precursor (GRPs) cells in the adult hippocampus as a novel therapeutic tool to modulate neuronal networks
Co-supervisor
Biochemistry (Degree)
Universidade do Minho, Portugal
2018/06 - 2018/09 BnML Summer Internship
Supervisor
Internship (Other)
BnML Behavioral and Molecular Lab Lda, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/10/18 - Current Participation and Poster Presentation - TBIO Annual Meeting, at E2S – Escola Superior de Saúde, in Porto, on the 18th of October 2024 “Does adult hippocampal gliogenesis modulate non-motor symptoms of PD? Understanding the role of newly-born glial cells in PD progression" - Martins-Macedo J, Gomes ED, Alves ND, Ribeiro I, Teixeira C, Soares-Guedes C, Araújo B, Caridade-Silva R, Vilela C, Pinto L, Teixeira FG.
Meeting
TBIO Annual Meeting, at E2S – Escola Superior de Saúde, in Porto, on the 18th of October 2024
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2024/10/03 - 2024/10/04 Participation and Poster Presentation - “7th PhDay: From Theory to Application: Research in Action” held at i3S - Instituto de Investigação e Inovação em Saúde, in Porto, on the 3rd and 4th of October 2024 - “Does adult hippocampal gliogenesis modulate non-motor symptoms of PD? Understanding the role of newly-born glial cells in PD progression." - Martins-Macedo J, Gomes ED, Alves ND, Ribeiro I, Teixeira C, Soares-Guedes C, Araújo B, Caridade-Silva R, Vilela C, Pinto L, Teixeira FG
Conference
7th PhDay: From Theory to Application: Research in Action
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/06/12 - 2024/06/14 Participation and Poster presentation in the 5th meeting - Adult Neurogenesis in Physiology and Disease. Poster title: "Gliogenesis in mood disorders: influence of Glial-Restricted Precursors in a model of cytogenesis abrogation"
Congress
5th meeting - Adult Neurogenesis in Physiology and Disease 12-13-14 June 2024 Bordeaux (France)
Victoire Campus - University of Bordeaux, France
2024/02/15 - 2024/02/17 Open Campus, Instituto Politécnico do Porto, 15-17 February 2024
Congress
Open Campus, Instituto Politécnico do Porto, 15-17 February 2024
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2021/05 - 2021/05 Participation and Poster presentation in "JRC Summer School on Non-Animal Approaches in Science - The Three R…evolution"
Congress
JRC Summer School on Non-Animal Approaches in Science - The Three R…evolution
2017/05/25 - 2017/05/26 XV SPN Meeting
Congress
XV SPN Meeting
Sociedade Portuguesa de Neurociências , Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/04/02 - 2024/04/09 Lecturer in the Course “FCT PhD Scholarship Project Training, 1st Edition, 02-09 April 2024”, 84h (Pós-Graduação) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Methods Collection: Glial Precursors Isolation and Characterization in CNS Disorders JoVE
Distinctions

Other distinction

2023 PhD scholarship - 2023.00893.BDANA
Fundação para a Ciência e a Tecnologia, Portugal