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José Lentilhas-Graça completed the Bachelor of Science in Basic Studies on Animal Health Sciences in 2009 and the Integrated Masters in Veterinary Medicine in 2010 by the Faculty of Veterinary Medicine of the University of Lisbon. He was a Research Trainee in the Prostate Cancer research field (2014 -2016) at Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine of the University of Lisbon. Currently, José is a PhD student in the Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC) (School of Medicine of the University of Minho, Faculty of Medicine of the University of Coimbra and NOVA Medical School|Faculdade de Ciências Médicas of the NOVA University of Lisbon). His research field is Neuroimmunology, studying the therapeutic role of Spleen Macrophages in Spinal Cord Injury and his PhD is carried out at Life and Health Sciences Research Institute (Instituto de Investigação em Ciências da Vida e Saúde, ICVS), School of Medicine, University of Minho, integrated in the ICVS/3B's Associate Laboratory, and at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. He published 4 articles in peer review journals, 2 as PhD student.
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Identification

Personal identification

Full name
JOSÉ CARLOS LENTILHAS DA GRAÇA

Citation names

  • Lentilhas-Graça, José
  • Graça, José L.
  • Graça, José

Author identifiers

Ciência ID
2F18-8015-9EE7
ORCID iD
0000-0003-3130-9556

Email addresses

  • id6519@alunos.uminho.pt (Professional)

Telephones

Telephone
  • 253604839 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Advanced (C1) Intermediate (B1) Beginner (A1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2016/09/15 - 2024
Ongoing
 Envelhecimento e Doenças Crónicas (associação) (Doutoramento)
Major in Sem especialidade
Universidade do Minho Escola de Medicina, Universidade de Coimbra Faculdade de Medicina, Universidade Nova de Lisboa NOVA medical school|Faculdade de Ciências Médicas, Portugal

Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Medicina, Universidade do Minho, integrado no Laboratório Associado ICVS/ 3B’s, Braga Portugal, e Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, Portugal
"Spinal Cord Injury: can recovery be achieved through the Spleen?" (THESIS/DISSERTATION)
2010
Concluded
 Integrated Masters in Veterinary Medicine (Mestrado)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"Otohematoma : estudo retrospectivo de 6 anos : possíveis etiologias" (THESIS/DISSERTATION)
 15 (15/20)
2009
Concluded
 Bachelor of Science in Basic Studies on Animal Health Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 15 (15/20)
Affiliation

Science

Category
Host institution 		Employer
2014/03/12 - 2016/06/30 Research Trainee (Research) Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Others

Category
Host institution 		Employer
2016/09/15 - Current PhD Student Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Medicina, Universidade do Minho, integrado no Laboratório Associado ICVS/ 3B’s, Braga Portugal, e Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, Portugal
Universidade do Minho Escola de Medicina, Universidade de Coimbra Faculdade de Medicina, Universidade Nova de Lisboa NOVA medical school|Faculdade de Ciências Médicas, Portugal , Portugal
2012/08/01 - 2012/09/30 Veterinarian in Veterinary Clinical Pathology and Veterinary Cytology VETinLAB - Análises Clínicas Veterinárias, VetPat, Portugal
2012/06/05 - 2012/07/31 Trainee in Veterinary Cytology Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2012/05/15 - 2012/05/25 Trainee in Veterinary Haematology and Cytology Nationwide Laboratories, United Kingdom
Nationwide Laboratories, United Kingdom
2011/07/01 - 2011/07/31 Veterinarian in Companion Animal Veterinary Clinics Veterinary Clinic of Algueirão , Portugal
2009/10/01 - 2010/03/31 Curricular Training in Companion Animal Clinics Veterinary Hospital of Restelo , Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2023/07/31 The peripheral sympathetic system as a target for immunomodulation in spinal cord injury pathophysiology
EXPL/MED-PAT/0931/2021
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/26 - 2021/07/25 Restoring the Functionality to the Injured Spinal Cord Through the Combinatory Action of Pharmaco-Therapies and Tissue Engineering Strategies
PTDC/CAL-EST/29206/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/02 - 2021/07/01 A Multidisciplinary Therapy to Repair the Injured Spinal Cord: Time to Move
PTDC/BTM-MAT/29968/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/11/30 Farmacologia e Células Estaminais para Reparar as Lesões da Medula Espinhal: Será o Todo Maior que a Soma das suas Partes?
PTDC/DTP-FTO/5109/2014
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Duarte, Antonio; Pedrosa, Ana-Rita; Trindade, Alexandre; Carvalho, Catarina; Graça, José; Carvalho, Sandra; Peleteiro, Maria C.; Adams, Ralf H.. "Abstract 5225: Endothelial-specific Jagged1 blockade prevents solid tumor growth in pre-clinical models". Paper presented in 106th Annual Meeting of the American Association for Cancer Research, Philadelphia, 2015.
    Published • 10.1158/1538-7445.am2015-5225
  2. Ana-Rita Pedrosa, Alexandre Trindade, Catarina Carvalho, José L. Graça, Sandra Carvalho, Maria Conceição Peleteiro; António Duarte. "Blocking Jagged1/2 inhibits prostate tumor development in a murine model of prostate adenocarcinoma (TRAMP)". Paper presented in 1st Associação Portuguesa de Investigação em Cancro (ASPIC) International Congress, Lisboa, 2014.
    Published
Conference poster
  1. Lentilhas-Graça, José ; João Afonso; Diogo J. Santos; Eduardo D. Gomes; Rui Lima; Andreia G. Pinho; Fernando Amorim; et al. "Polarized Splenic Macrophages and Spinal Cord Injury Repair: The Secretome Effect". Paper presented in 39th Annual Symposium of the National Neurotrauma Society, 2022.
  2. Lentilhas-Graça, José ; João Afonso; Diogo J. Santos; Eduardo D. Gomes; Rui Lima; Andreia G. Pinho; Nídia de Sousa; et al. "Splenic Macrophages on Spinal Cord Injury Repair: The Secretome Effect". Paper presented in 2nd International meeting of portuguese spinal cord injury researchers, 2022.
  3. Lentilhas-Graça, José ; João Afonso; Diogo J. Santos; Eduardo D. Gomes; Rui Lima; Andreia G. Pinho; Nídia de Sousa; et al. "STUDYING THE THERAPEUTIC EFFECT OF ACTIVATED SPLEEN MACROPHAGES SECRETOME ON SPINAL CORD INJURY REPAIR". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  4. J.L. Graça, E.D. Gomes, R. Lima, S.C. Serra, J. Afonso, I.M. Pereira, S. Monteiro, A.J. Salgado, R.D. Almeida; N.A. Silva. "Exploring the Effects of Spleen-derived M2 Macrophages for Spinal Cord Injury Repair". Paper presented in 1st Minho Meeting on Spinal Cord Injury and 1st International Meeting of the Portuguese Network for Spinal Cord Injury Research, 2019.
  5. Graça JL, Gomes ED, Lima R, Serra SC, Afonso J, Monteiro S, Salgado AJ, Almeida RD, Silva NA. "Effects of M2 Spleen–derived Macrophages on Axonal Regeneration". Paper presented in 1st International Symposium Secretome With]Out[ Borders, 2018.
  6. Ana-Rita Pedrosa, Alexandre Trindade, Catarina Carvalho, José Graça, Sandra Carvalho, Maria Conceição Peleteiro; Ralf H. Adams, António Duarte. "Endothelial Jagged1 regulates tumour perfusion and growth in a murine model of prostate adenocarcinoma (TRAMP)". Paper presented in Vascular Biology 2014, 2014.
Journal article
  1. Lentilhas-Graça, José; Santos, Diogo J.; Afonso, João; Monteiro, Andreia; Pinho, Andreia G.; Mendes, Vera M.; Dias, Marta S.; et al. "The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol". Frontiers in Immunology 15 (2024): http://dx.doi.org/10.3389/fimmu.2024.1354479.
    10.3389/fimmu.2024.1354479
  2. Pinho, Andreia G.; Cibrão, Jorge R.; Lima, Rui; Gomes, Eduardo D.; Serra, Sofia C.; Lentilhas-Graça, José; Ribeiro, C.; et al. "Immunomodulatory and regenerative effects of the full and fractioned adipose tissue derived stem cells secretome in spinal cord injury". Experimental Neurology 351 (2022): 113989. http://dx.doi.org/10.1016/j.expneurol.2022.113989.
    10.1016/j.expneurol.2022.113989
  3. Monteiro, Susana; Pinho, Andreia G.; Macieira, Mara; Serre-Miranda, Cláudia; Cibrão, Jorge R.; Lima, Rui; Soares-Cunha, Carina; et al. "Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord". Journal of Neuroinflammation 17 1 (2020): http://dx.doi.org/10.1186/s12974-020-01945-8.
    10.1186/s12974-020-01945-8
  4. Pedrosa, A.-R.; Graça, J.L.; Carvalho, S.; Peleteiro, M.C.; Duarte, A.; Trindade, A.. "Notch signaling dynamics in the adult healthy prostate and in prostatic tumor development". Prostate 76 1 (2015): 80-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942800866&partnerID=MN8TOARS.
    Published • 10.1002/pros.23102
  5. Pedrosa, A.-R.; Trindade, A.; Carvalho, C.; Graça, J.; Carvalho, S.; Peleteiro, M.C.; Adams, R.H.; Duarte, A.. "Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions". Oncotarget 6 27 (2015): 24404-24423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943408033&partnerID=MN8TOARS.
    Published • 10.18632/oncotarget.4380
Thesis / Dissertation
  1. Graça, José Carlos Lentilhas da. "Otohematoma : estudo retrospectivo de 6 anos : possíveis etiologias". Master, Universidade de Lisboa Faculdade de Medicina Veterinária, 2010. http://hdl.handle.net/10400.5/2586.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/03/25 Spinal cord injury: can recovery be achieved through the spleen? X Annual PhDOC Meeting
Universidade do Minho, Escola de Medicina (Braga, Portugal)
2020/10/30 Spinal Cord Injury: can recovery be achieved through the Spleen? IX Annual PhDOC Meeting
Universidade Nova de Lisboa, Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (Lisbon (Lisboa), via ZOOM, Portugal)
2019/10/31 Spinal Cord Injury: can recovery be achieved through the Spleen? VIII Annual PhDOC meeting
Universidade de Coimbra, Faculdade de Medicina (Coimbra, Portugal)
2018/10/18 Spinal Cord Injury: can recovery be achieved through the Spleen? VII Annual PhDOC meeting
Universidade do Minho, Escola de Medicina (Braga, Portugal)
2017/11/09 Spinal Cord Injury: can recovery be achieved through the Spleen? VI Annual PhDOC meeting
Universidade Nova de Lisboa, Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (Lisbon (Lisboa), Portugal)
2016/04/28 Notch Signaling Dynamics in the Adult Healthy Prostate and in Prostatic Tumor Development 2nd Associação Portuguesa de Investigação em Cancro (ASPIC) International Congress
IPO-PORTO (Oporto (Porto), Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/07/15 - 2019/07/15 1st Minho Meeting on Spinal Cord Injury and 1st International Meeting of the Portuguese Network for Spinal Cord Injury Research (2019/07/15 - 2019/07/15)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2018/10/18 - 2018/10/19 VII Annual PhDOC Meeting (2018/10/18 - 2018/10/19)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/11/14 - 2017/11/14 Vertebro-medullary lesions
Conference
 3a Edição das Conferências Santa Casa Neurociências - Lesões Vertebro-Medulares, Lisbon (Lisboa)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/10/14 - 2016/10/15 Encontro
Meeting
 V Annual PhDOC meeting
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/05/09 - 2013/05/10 Animal Pathology
Meeting
 XVIII Meeting of the Portuguese Society of Animal Pathology - International Meeting of Leporidae Pathology
Universidade de Évora, Portugal

Association member

Society Organization name Role
2011 - Current Ordem dos Médicos Veterinários Member
Distinctions

Other distinction

2016 PhD fellowship - PD/BD/127820/2016 in Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC)
Fundação para a Ciência e a Tecnologia, Portugal