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I obtained my PhD at the University of Oxford, UK, in Dr. Madalena Tarsounas laboratory, studying the role of DNA damage responses in maintaining genomic stability and preventing tumorigenesis. After my PhD, driven by my interest in disease mechanism, I joined Dr. Miguel Soares laboratory at Instituto Gulbenkian de Ciência (IGC), Portugal. I was awarded a postdoctoral fellowship by the Portuguese Foundation for Science and Technology (FCT) in 2014 to address how regulation of iron-heme metabolism impacts steady-state and the establishment of disease tolerance to different types of infection. In 2019, I was awarded by FCT with an Assistant Researcher position and with a L’Oréal Portugal Medals of Honor for Women in Science to pursue a new line of research where I combined my expertise on DNA damage and oxidative stress and mechanisms of disease, particularly intra- and extracellular communication, tackling the mechanisms behind LAMA2-related muscular dystrophies. In 2022, with this line of work I was rewarded with a competitive tenure track position as an Assistant Professor at the Faculty of Sciences, University of Lisbon. Throughout my career I have worked with a wide spectrum of in vitro (human and mouse cells) and in vivo (mouse models) models of disease (cancer, malaria, sepsis, iron deregulation, Lama2-deficiency). I have developed new cell lines using CRISPR-Cas9, lentiviral, retroviral or plasmid transfections. I have engaged in multiomics approaches including microRNA analysis, mRNA sequencing and metabolomics. This allowed me to gain crucial insights into disease mechanisms. I am member and co-leader of Working Group 5 of the COST Action “Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases” BenBedPhar(CA-20121). In addition, I am member and ambassador in the European Association for Cancer Research (EACR) and member of the Portuguese Cancer Research Association (ASPIC). I participated as Guest Editor in three special issues: Frontiers in Genetics, International Journal of Molecular Sciences and JoVE. I am also a reviewer for several international journals, including Cell Death and Disease, Cells, Antioxidants and Frontiers in Genetics. I have participated in science communication initiatives both within the research community, attending national and international conferences, where I presented my work both as oral communications (over 15) and posters (over 25). I have also engaged in various science outreach initiatives, being part of the book "Women in Science 2021" (Portugal), as well as participating in television and radio shows dedicated to science communication. I participated in science dissemination activities dedicated to schools and other lay audiences. I have been co-organizer of scientific events including the COST Action BenBedPhar 2023 Open day and the Second Annual Joint Postdoctoral Meeting Lisbon 2015. I have supervised 10 MSc students and currently I am supervising 4 MSc students and 4 PhD students. My role in teaching started in 2013, as an invited lecturer at Faculty of Sciences (University of Lisbon), first teaching Biomolecular Methods and later also Molecular and Cell Biology of Cancer. As a direct consequence of my participation in the second topic, I am the author of a book chapter (Springer International Publishing 2019). Since 2020, until my recent appointment as an Assistant Professor, I was lecturer at Ciências in Physiology (BSc level) and Genes and Molecules in Development and Seminars in Evolutionary Biology and Development (both at MSc level). SCIENTIFIC METRICS SCOPUS (February 2025) No. of accepted publications 23 No. of first author publications 9 No. of last author publications 3 Times Cited 1039 H Index 14 Average Citations per Item 45 Articles with impact factor >10 11
Identification

Personal identification

Full name
Ana Rita Cabral Martins Carlos

Citation names

  • Carlos, Ana Rita

Author identifiers

Ciência ID
2E10-CE9E-ECE4
ORCID iD
0000-0002-6953-1163
Researcher Id
K-6014-2019

Email addresses

  • arcarlos@ciencias.ulisboa.pt (Professional)

Telephones

Telephone
  • 217500000 Ext.: 522347 (Professional)

Addresses

  • Departamento de Biologia Animal Faculdade de Ciências, Universidade de Lisboa, Campo Grande , 1749-016 , Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pathology
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Pathology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2009/01/01 - 2013/01/18
Concluded
DPhil in Radiobiology (Doctor of Philosophy)
University of Oxford, United Kingdom
"DNA damage responses to loss of telomere integrity" (THESIS/DISSERTATION)
N/A
2008/11/08
Concluded
Mestrado em Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Análise da expressão génica em estirpes de Enterococcus como resposta a diferentes condições ambientais" (THESIS/DISSERTATION)
19
2007
Concluded
Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"(Não aplicável)" (THESIS/DISSERTATION)
17
Affiliation

Science

Category
Host institution
Employer
2022/11/14 - Current Principal Investigator (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/06/01 - 2022/11/13 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Centro de Ecologia Evolução e Alterações Ambientais, Portugal
2013/03/01 - 2019/05/31 Postdoc (Research) Fundação Calouste Gulbenkian, Portugal
Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2022/11/14 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2022/03/01 - Current Extracellular matrix in health and disease
CE3C#1036
Researcher
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Centro de Ecologia Evolução e Alterações Ambientais, Portugal
Ongoing
2022/01/15 - Current Overcoming the challenges of recombinant adenoassociated virus production to treat Muscular dystrophy
PTDC/BTM-ORG/1383/2020
Researcher
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
2020/09/11 - 2023/09/10 Understanding the responses of fetal muscle stem cells and myoblasts to their niche in a mouse model for LAMA2-CMD
23049
Researcher
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
AFM-Téléthon
Ongoing
2020/03/01 - 2022/12/31 Role of senescence on the onset of muscle dystrophy
0846-Prémio L'Oreal
Principal investigator
Centro de Ecologia Evolução e Alterações Ambientais, Portugal
L'Oréal Portugal, Unipessoal, Lda
Ongoing
2018/06/01 - 2019/05/31 Metabolic adaptation to infectious diseases
LISBOA-01-145-FEDER-029411
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
2013/06 - 2016/05 TREAT LIVER DISEASES BY TARGETING HEPATOCYTE NECROPTOSIS Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2025/01/01 - 2026/06/30 Targeting LAMA2-MD with CRISPR-Cas9 based gene therapy
2023.11177.PEX
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Goldsmiths University of London, United Kingdom

Sorbonne Université, France
Fundação para a Ciência e a Tecnologia
Ongoing
2025/01/01 - 2026/06/30 A novel role for LAMA2, an extracellular matrix component, in melanoma progression
2023.15036.PEX
Co-Principal Investigator (Co-PI)
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Goldsmiths University of London, United Kingdom

Fundação Champalimaud, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 CHANGE - Instituto para as Alterações Globais e Sustentabilidade
LA/P/0121/2020
Universidade do Algarve, Portugal

Fundação Gaspar Frutuoso, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo, Portugal

Universidade de Évora, Portugal

Universidade Nova de Lisboa Centro de Investigação em Ambiente e Sustentabilidade, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/06/01 - 2022/11/13 Mechanisms underlying JAK-STAT overactivation in Lama2-deficient congenital muscular dystrophy
CEECIND/01589/2017
Researcher
Centro de Ecologia Evolução e Alterações Ambientais, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2022/05/31 Metabolic adaptation to infectious diseases
PTDC/SAU-INF/29411/2017
Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto Gulbenkian de Ciência
UID/Multi/04555/2019
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/06/01 - 2018/09/30 DNA Damage and Disease Tolerance
SFRH/BPD/101608/2014
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/01 - 2012/12/31 ROLES OF HUMAN RAP1 PROTEIN IN TELOMERE MAINTENANCE AND GENOMIC INTEGRITY
SFRH/BD/47326/2008
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2021/12 - Current Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases
CA20121
Work Group Member
European Cooperation in Science and Technology, Belgium
Ongoing
2009/10/01 - 2009/10/31 STSM BM0703: European Cooperation in Science and Technology (COST)-Cancer and Genomic Control of Integrity (CANGENIN)
PhD Student Fellow
Danish Cancer Society Research Center, Denmark
Concluded
Outputs

Publications

Book chapter
  1. Carlos, Ana Rita. "Genomic Instability: DNA Repair and Cancer". 2019.
    10.1007/978-3-030-11812-9_5
Conference poster
  1. Ribeiro, Vanessa; Lopes, Ana Sofia; Conceição, Andreia; Fonseca, Inês; Ferreira, João; Mocho, Érica; Martins, Susana (F918-A1C4-98BF); et al. "LAMA2-DEFFICIENCY IMPACTS DNA DAMAGE IN MELANOMA". Paper presented in CE3C: the 10th Frontiers in E3, 2024.
  2. Caldeira, Inês; Ventura, Inês; Ribeiro, Vanessa; Carlos, Ana Rita; Santos, Romana. "Analysis of the effect of hydrodynamism on the regulation of sea urchin adhesion: a molecular and biomechanical approach". Paper presented in CE3C: the 10th Frontiers in E3, 2024.
  3. Martins, Susana G; Ribeiro, Vanessa; Pita, Mafalda; Melo, Catarina; Paulino-Cavaco, Cláudia; Antonini, Dario; Naidu, Sharadha Dayalan; et al. "Laminin-a2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms". Paper presented in CE3C: the 10th Frontiers in E3, 2024.
  4. Marques, Luís; Alves, Ana Mafalda; Martins, Susana G; Carlos, Ana Rita; Thorsteinsdottir, Solveig. "Analyzing AKT in skeletal muscle in development and disease". Paper presented in CE3C: the 10th Frontiers in E3, 2024.
  5. Martins, Susana G; Ribeiro, Vanessa; Pita, Mafalda; Melo, Catarina; Paulino-Cavaco, Cláudia; Antonini, Dario; Naidu, Sharadha Dayalan; et al. "Laminin-a2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms". Paper presented in 8th BenBedPhar Scientific Meeting, Lisbon, Portugal, 2024.
  6. Ribeiro, Vanessa; Lopes, Ana Sofia; Conceição, Andreia; Fonseca, Inês; Ferreira, João; Mocho, Érica; Martins, Susana G; et al. "LAMA2-Deficiency impacts DNA damage in melanoma". Paper presented in 4th Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference, Fusion Conferences,St. Julians, Malta, 2024.
  7. Ribeiro, Vanessa; Conceição, Andreia; Lopes, Ana Sofia; Fonseca, Inês; Luiz, Hugo; Martins, Susana (F918-A1C4-98BF); Thorsteinsdottir, Solveig; et al. Corresponding author: Carlos, Ana Rita. "Impact of changes in ECM in melanoma". Paper presented in EACR-AstraZeneca Conference – Cancer Epigenetics, 2023.
  8. Martins, Susana (F918-A1C4-98BF); Ribeiro, Vanessa; Melo, Catarina; Paulino-Cavaco, Cláudia; Dayalan Naidu, Sharadha; Fonseca, Inês; Saget, Bérénice; et al. Corresponding author: Carlos, Ana Rita. "Deregulation of multiple mechanisms shape the onset of LAMA2-congenital muscular dystrophy". Paper presented in 5th Scientific Meeting of BenBedPhar, 2023.
  9. Lopes, Ana Sofia; Conceição, Andreia; Ribeiro, Vanessa; Fonseca, Inês; Luiz, Hugo; Martins, Susana (F918-A1C4-98BF); Ferreira, João; et al. Corresponding author: Carlos, Ana Rita. "Impact of changes in ECM in melanoma". Paper presented in cE3c 9th Annual Meeting - Frontiers in E3, 2023.
  10. R. Fernandes, Diogo; Moura, Filipa; Thorsteinsdottir, Solveig; JM Escandell; Carlos, Ana Rita. Corresponding author: Carlos, Ana Rita. "LAMA2-CMD: establishment of a new gene therapy strategy using an in vitro model". Paper presented in cE3c 9th Annual Meeting - Frontiers in E3, 2023.
  11. Conceição, Andreia; Neves, Maria; Fonseca, Inês; Ribeiro, Vanessa; Martins, Susana (F918-A1C4-98BF); Luiz, Hugo; Thorsteinsdottir, Solveig; et al. Corresponding author: Carlos, Ana Rita. "Analyzing the impact of air pollution and changes in ECM in Melanoma". Paper presented in Jornadas Cientificas ULisboa, 2023.
  12. Lopes, Ana Sofia; Conceição, Andreia; Ribeiro, Vanessa; Fonseca, Inês; Luiz, Hugo; Martins, Susana (F918-A1C4-98BF); Thorsteinsdottir, Solveig; et al. Corresponding author: Carlos, Ana Rita. "Impact of LAMA2-deficiency in cancer". Paper presented in EACR: Stem Cell Biology, Cancer Plasticity and Therapeutic Potential, 2023.
  13. Martins, Susana G; Ribeiro, Vanessa; Paulino-Cavaco, Cláudia; Melo, Catarina; Luiz, Hugo; Fonseca, Inês; Saget, Bérénice; Carlos, Ana Rita; Thorsteinsdottir, Solveig. Corresponding author: Carlos, Ana Rita. "Proliferation and differentiation defects are key events for the onset of LAMA2-congenital muscular dystrophy". Paper presented in MDA Clinical &Scientific Conference, 2023.
  14. Fernandes, Diogo R; Thorsteinsdottir, Solveig; JM Escandell; Carlos, Ana Rita. "LAMA2-CMD: establishment of a new gene therapy strategy using an in vitro model". Paper presented in 2023 MDA Clinical & Scientific Conference, 2023.
  15. Lopes, Ana Sofia; Fonseca, Inês; Ribeiro, Vanessa; Luiz, Hugo; Martins, Susana G; Conceição, Andreia; Marques, Luís; et al. "Impact of LAMA2-deficiency in cancer". Paper presented in Champalimaud Research Symposium - Tumor Microenvironment, 2022.
  16. Ribeiro, Vanessa; Martins, Susana G; Melo, Catarina; Fonseca, Inês; Murtinheira, Fernanda; Herrera, Federico; Zilhão, Rita (CF15-75FB-F490); et al. "Laminin 211 is required for cell proliferation and myoblast differentiation in mouse models for LAMA2-congenital muscular dystrophy". Paper presented in 19th International Congress of Developmental Biology, 2022.
  17. Ribeiro, Vanessa; Martins, Susana G; Melo, Catarina; Gameiro dos Santos, Pedro; Soares, Ana Rita; Saget, Bérénice; Rodrigues, Gabriela; Carlos, Ana Rita; Thorsteinsdottir, Solveig. Corresponding author: Carlos, Ana Rita. "Lama2-deficiency impacts on Nfix and Myogenin pathways and myoblast differentiation". Paper presented in Myology/Mitonice 2022, 2022.
  18. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Bérénice; Carlos, Ana Rita; Thorsteinsdottir, Solveig. Corresponding author: Carlos, Ana Rita. "Onset of LAMA2-congenital muscular dystrophy involves cell cycle deregulation, altered redox metabolism and DNA damage". Paper presented in Myology/Mitonice 2022, 2022.
  19. Fonseca, Inês; Lopes, Ana Sofia; Martins, Susana G; Melo, Catarina; Ribeiro, Vanessa; Marques, Luís; Luiz, Hugo; et al. Corresponding author: Carlos, Ana Rita. "Impact of LAMA2-deficiency in cancer". Paper presented in PORTO CANCER MEETING Extracellular Vesicles, Cell Communication and Cancer Time to Prick the Bubble, 2022.
  20. Dias-Silva, Manuel; Gomes, André M. C.; Carlos, Ana Rita; Fernandes, Susana M. "Alveolar epithelial cells upregulate CCR10 expression during wound repair". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  21. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Bérénice; Thorsteinsdottir, Solveig; Carlos, Ana Rita. "Onset of LAMA2-congenital muscular dystrophy is characterized by defective cell proliferation and altered redox metabolism". Paper presented in Cell Symposia: Metabolites in Signaling and Disease, 2022.
  22. Ribeiro, Vanessa; Martins, Susana G; Melo, Catarina; Gameiro dos Santos, Pedro; Soares, Ana Rita; Saget, Bérénice; Rodrigues, Gabriela; Carlos, Ana Rita; Thorsteinsdottir, Solveig. Corresponding author: Carlos, Ana Rita. "Lama2-deficiency impacts on Nfix and Myogenin pathways and myoblast differentiation". Paper presented in 2022 MDA Clinical & Scientific Conference, 2022.
  23. Martins, Susana G; Melo, Catarina; Fonseca, Inês; Ribeiro, Vanessa; Saget, Bérénice; Thorsteinsdottir, Solveig; Carlos, Ana Rita. Corresponding author: Carlos, Ana Rita. "Onset of LAMA2-congenital muscular dystrophy in the mouse involves cell cycle deregulation, oxidative stress and DNA damage". Paper presented in 2022 MDA Clinical & Scientific Conference, 2022.
  24. Martins, Susana G; Gameiro dos Santos, Pedro; Cordero, G.A.; Melo, Catarina; Ribeiro, Vanessa; Antunes, Inês; Saget, Bérénice; et al. "LAMA2 congenital muscular dystrophy: the road to unravel the disease onset". Paper presented in Ciências Research Day 2021, 2021.
  25. Melo, Catarina; Saget, Bérénice; Martins, Susana G.; Rodrigues, Gabriela; Thorsteinsdottir, Solveig; Carlos, Ana Rita. Corresponding author: Carlos, Ana Rita. "Lama2-deficiency impacts on mechanisms involved in cell cycle regulation and survival". Paper presented in Frontiers in E3 7th Annual Meeting, 2021.
  26. Ribeiro, Vanessa; Martins, Susana G; Domingues, Ana Raquel; Pereira, Maria João; Carlos, Ana Rita; Thorsteinsdottir, Solveig. "How Lama2 deficiency impacts on Nfix and Myogenin pathways". Paper presented in Frontiers in E3 7th Annual Meeting, 2021.
  27. Fonseca, Inês; Lopes, Ana Sofia; Martins, Susana G; Pinto, Daniel; Ramos, Sância; Zilhão, Rita; Carlos, Ana Rita. Corresponding author: Carlos, Ana Rita. "Differential expression of extracellular matrix components in cancer". Paper presented in Frontiers in E3 7th Annual Meeting, 2021.
  28. Nunes, Andreia; Martins, Susana G; Antunes, Inês; Ybot-Gonzalez P.; Deries, M; Pinto-do-Ó, Perpetua; Carlos, Ana Rita; Nascimento, Diana; Thorsteinsdottir, Solveig. "Laminin remodeling during cardiac muscle development". Paper presented in Spanish & Portuguese Advanced Optical Microscopy Meeting 2020, 2020.
  29. Carlos, Ana Rita; Weis, Sebastian; Moita, Maria Raquel; Singh, Sumnima; Blankenhaus, Birte; Cardoso, Silvia; Larsen, Rasmus; et al. "Iron-mediated control of glucose metabolism is central to promote disease tolerance to polymicrobial infections". Paper presented in 19th SFRRI Biennial Meeting, 2018.
  30. Carlos, Ana Rita; Gozzelino, Raffaella; Soares, Miguel. "A protective role for ATM in hemolytic conditions". Paper presented in 19th biennial meeting SFRRI, 2018.
  31. Carlos, Ana Rita; Badie, S.; Jonkers, J.; Tarsounas, M.. "Roles of BRCA1 and CtIP in processing uncapped telomeres". Paper presented in EMBO Meeting - Telomeres and the DNA damage response, 2012.
  32. Carlos, Ana Rita; Tarsounas, M.. "Functions of human RAP1 in telomere and genome integrity". Paper presented in National Cancer Research Institute (NCRI) Cancer Conference, 2009.
  33. Carlos, Ana Rita; Semedo-Lemsaddek, Teresa; Barreto-Crespo, M.T.; Tenreiro, R. "Differential expression of enterococcal virulence-related genes: clinical versus food strains". Paper presented in The European Society of Clinical Microbiology and Infectious Diseases (ECCMID), 2009.
  34. Semedo-Lemsaddek, Teresa; Carlos, Ana Rita; Santos, J.; Vale de Gato, I.; Chambel, L.; Barreto-Crespo, M.T.; Tenreiro, R.. "Environmental adaptability: are clinical and food enterococci so much different?". Paper presented in International Union of Microbiological Societies (IUMS), International Congress of Bacteriology and Applied Microbiology, 2008.
Journal article
  1. Rojo AI; Buttari B; Cadenas S; Carlos AR; Cuadrado A; Falcão AS; López MG; et al. "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.". Redox biology (2024): http://europepmc.org/abstract/med/39709790.
    10.1016/j.redox.2024.103464
  2. Martins SG; Ribeiro V; Melo C; Paulino-Cavaco C; Antonini D; Dayalan Naidu S; Murtinheira F; et al. "Laminin-a2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms.". Life science alliance (2024): http://europepmc.org/abstract/med/39379105.
    10.26508/lsa.202402829
  3. Susana Ramos; Viktoria Jeney; Ana Figueiredo; Tiago Paixão; Maria Rosário Sambo; Vatúsia Quinhentos; Rui Martins; et al. "Targeting circulating labile heme as a defense strategy against malaria". Life Science Alliance (2024): https://doi.org/10.26508/lsa.202302276.
    10.26508/lsa.202302276
  4. Qian Wu; Ana Rita Carlos; Faouzi Braza; Marie-Louise Bergman; Jamil Z Kitoko; Patricia Bastos-Amador; Eloy Cuadrado; et al. "Ferritin heavy chain supports stability and function of the regulatory T cell lineage". The EMBO Journal (2024): https://doi.org/10.1038/s44318-024-00064-x.
    10.1038/s44318-024-00064-x
  5. Vanessa Ribeiro; Susana G. Martins; Ana Sofia Lopes; Sólveig Thorsteinsdóttir; Rita Zilhão; Ana Rita Carlos. "NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24054293.
    10.3390/ijms24054293
  6. Sara Petrillo; F. De Giorgio; F. Bertino; F. Garello; V. Bitonto; D. L. Longo; S. Mercurio; et al. "Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis". Angiogenesis (2023): http://dx.doi.org/10.1007/s10456-023-09865-w.
    10.1007/s10456-023-09865-w
  7. Ramos, Susana; Ademolue, Temitope W.; Jentho, Elisa; Wu, Qian; Guerra, Joel; Martins, Rui; Pires, Gil; et al. "A hypometabolic defense strategy against malaria". Cell Metabolism 34 8 (2022): 1183-1200.e12. http://dx.doi.org/10.1016/j.cmet.2022.06.011.
    10.1016/j.cmet.2022.06.011
  8. Carlos, Ana Rita; Allamand, Valérie. "Editorial: Extracellular matrix in homeostasis and cancer". (2022): http://hdl.handle.net/10451/55761.
    10.3389/fgene.2022.1107969
  9. Singh, S.; Thompson, J.A.; Yilmaz, B.; Li, H.; Weis, S.; Sobral, D.; Truglio, M.; et al. "Loss of a-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis". Cell Host and Microbe (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100766609&partnerID=MN8TOARS.
    10.1016/j.chom.2020.12.017
  10. Martins, Susana G.; Zilhão, Rita; Thorsteinsdottir, Solveig; Carlos, Ana Rita. "Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components". (2021): http://hdl.handle.net/10451/49224.
    10.3389/fgene.2021.673002
  11. Martins, Rui; Carlos, Ana Rita; Braza, Faouzi; Thompson, Jessica A.; Bastos-Amador, Patricia; Ramos, Susana; Soares, Miguel P.. "Disease Tolerance as an Inherent Component of Immunity". Annual Review of Immunology 37 1 (2019): 405-437. http://dx.doi.org/10.1146/annurev-immunol-042718-041739.
    10.1146/annurev-immunol-042718-041739
  12. Blankenhaus, B.; Braza, F.; Martins, R.; Bastos-Amador, P.; González-García, I.; Carlos, A.R.; Mahu, I.; et al. "Ferritin regulates organismal energy balance and thermogenesis". Molecular Metabolism (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063740016&partnerID=MN8TOARS.
    10.1016/j.molmet.2019.03.008
  13. Ramos, S.; Carlos, A.R.; Sundaram, B.; Jeney, V.; Ribeiro, A.; Gozzelino, R.; Bank, C.; et al. "Renal control of disease tolerance to malaria". Proceedings of the National Academy of Sciences of the United States of America 116 12 (2019): 5681-5686. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063288166&partnerID=MN8TOARS.
    10.1073/pnas.1822024116
  14. Carlos, A.R.; Weis, S.; Soares, M.P.. "Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance". Frontiers in immunology 9 (2018): 2498-2498. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056527033&partnerID=MN8TOARS.
    10.3389/fimmu.2018.02498
  15. Gouveia, Z.; Carlos, A.R.; Yuan, X.; Aires-da-Silva, F.; Stocker, R.; Maghzal, G.J.; Leal, S.S.; et al. "Characterization of plasma labile heme in hemolytic conditions". FEBS Journal 284 19 (2017): 3278-3301. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029000547&partnerID=MN8TOARS.
    10.1111/febs.14192
  16. Weis, S.; Carlos, A.R.; Moita, M.R.; Singh, S.; Blankenhaus, B.; Cardoso, S.; Larsen, R.; et al. "Metabolic Adaptation Establishes Disease Tolerance to Sepsis". Cell 169 7 (2017): 1263-1275.e14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020812716&partnerID=MN8TOARS.
    10.1016/j.cell.2017.05.031
  17. Carlos, A.R.; Weis, S.; Soares, M.P.. "Cross-Regulation of Iron and Glucose Metabolism in Response to Infection". Biochemistry 56 43 (2017): 5713-5714. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032640090&partnerID=MN8TOARS.
    10.1021/acs.biochem.7b00728
  18. Badie, S.; Carlos, A.R.; Folio, C.; Okamoto, K.; Bouwman, P.; Jonkers, J.; Tarsounas, M.. "BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres". EMBO Journal 34 3 (2015): 410-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922320494&partnerID=MN8TOARS.
    10.15252/embj.201488947
  19. Carlos, A.R.; Escandell, J.M.; Kotsantis, P.; Suwaki, N.; Bouwman, P.; Badie, S.; Folio, C.; et al. "ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets". Nature Communications 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899098006&partnerID=MN8TOARS.
    10.1038/ncomms3697
  20. Badie, S.; Escandell, J.M.; Bouwman, P.; Carlos, A.R.; Thanasoula, M.; Gallardo, M.M.; Suram, A.; et al. "BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping". Nature Structural and Molecular Biology 17 12 (2010): 1461-1469. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649837330&partnerID=MN8TOARS.
    10.1038/nsmb.1943
  21. Martinez, P.; Thanasoula, M.; Carlos, A.R.; Gómez-López, G.; Tejera, A.M.; Schoeftner, S.; Dominguez, O.; et al. "Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites". Nature Cell Biology 12 8 (2010): 768-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955173402&partnerID=MN8TOARS.
    10.1038/ncb2081
  22. Carlos, A.R.; Semedo-Lemsaddek, T.; Barreto-Crespo, M.T.; Tenreiro, R.. "Transcriptional analysis of virulence-related genes in enterococci from distinct origins". Journal of Applied Microbiology 108 5 (2010): 1563-1575. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950658716&partnerID=MN8TOARS.
    10.1111/j.1365-2672.2009.04551.x
  23. Carlos, A.R.; Santos, J.; Semedo-Lemsaddek, T.; Barreto-Crespo, M.T.; Tenreiro, R.. "Enterococci from artisanal dairy products show high levels of adaptability". International Journal of Food Microbiology 129 2 (2009): 194-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-59249092223&partnerID=MN8TOARS.
    10.1016/j.ijfoodmicro.2008.11.003
Preprint
  1. Martins, Susana G; Ribeiro, Vanessa; Melo, Catarina; Paulino-Cavaco, Claudia; Antonini, Dario; Dayalan Naidu, Sharadha; Murtinheira, Fernanda; et al. Corresponding author: Carlos, Ana Rita. "Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy". 2024. http://dx.doi.org/10.1101/2024.01.20.576409.
    10.1101/2024.01.20.576409

Other

Other output
  1. A hypometabolic defense strategy against plasmodium infection. 2021. Ramos, S.; Ademolue, T.W.; Jentho, E.; Wu, Q.; Guerra, J.; Martins, R.; Pires, G.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118235633&partnerID=MN8TOARS.
    10.1101/2021.09.08.459402
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/12 Mouse and human models to test LAMA2-MD therapeutic approaches CE3C: the 10th Frontiers in E3
CE3C (Lisbon, Portugal)
2024/10/10 Laminin-a2 chain deficiency leads to multi-organ oxidative stress 8th BenBedPhar Scientific Meeting, Lisbon, Portugal
COST Action - BenBedPhar (Lisbon, Portugal)
2024/03/05 Qual a importância da matriz extracelular para a célula?! NEBFCUL - XII Jornadas de Investigação em Biologia
Faculty of Sciences, University of Lisbon (Lisbon, Portugal)
2023/09/07 Using p53 deletion to revert LAMA2-congenital muscular dystrophy Frontiers in E3 - 9th cE3c annual meeting
(Lisbon, Portugal)
2023/09/07 Lama2-deficiency impacts myoblast differentiation in a mouse model for LAMA2- congenital muscular dystrophy Frontiers in E3 - 9th cE3c annual meeting
(Lisbon, Portugal)
2023/09/07 Impact of environmental pollutants in the skin: cell physiology and genetic changes cE3c 9th Annual Meeting - Frontiers in E3
(Lisbon, Portugal)
2021/10/01 LAMA2-CMD: disease mechanisms in skeletal muscle and heart Frontiers in E3 7th Annual Meeting
cE3c (Lisboa, Portugal)
2021/03/05 Mecanismos de doença: o percurso de uma bióloga IX Jornadas de Investigação em Biologia
NEB-FCUL (Lisboa, Portugal)
2020/10/28 Studying the mechanisms that trigger congenital muscular dystrophy Ciências Research Day 2020
2020/10/01 Disease mechanisms in LAMA2-CMD: mitochondrial dysfunction 6th cE3c Annual Meeting
2018/06/04 Heme regulation of glucose metabolism in bloodstream infections. SFRRI 2018, Lisbon, Portugal. 19th SFRRI Biennial Meeting
2018/03/15 Metabolic adaptation as a protective strategy against infectious diseases; 14th International SPDM Symposium 14th International SPDM Symposium
(Porto, Portugal)
2017/09/11 Weis S, Carlos AR, et al (2017). Ferritin heavy chain controls glucose metabolism and affords disease tolerance in sepsis. International Sepsis Forum, Paris, France. International Sepsis Forum
2017/05/19 Oral Presentation: Soares MP (2017) Metabolic Adaptation establishes disease tolerance to sepsis. American Thoracic Society 2017 International Conference, Washington, USA. American Thoracic Society 2017 International Conference
2011/05/03 Roles of BRCA1 and CtIP in processing uncapped telomeres; Cold Spring Harbor Laboratory (CSHL) Telomeres and Telomerase
Cold Spring Harbor Laboratory (CSHL) (Cold Spring Harbor, United States)
2008/09/01 Protein Differential-Display Analysis in Enterococci from Portuguese Ewe's Artisanal Cheeses. Food Micro 2008 Food Micro 2008, Dairy Microbiology
(Aberdeen, Scotland, United Kingdom)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2024/11/20 - Current Establishment of a new gene therapy strategy for LAMA2-MD using mice and patient-derived 3D in vitro models.
Supervisor
PhD in Biology (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/09/16 - Current Unravelling the first defects o f LAMA2 congenital muscular dystrophy: muscle stem cells versus myofibers
Co-supervisor
Master in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/09/16 - Current LAMA2 MD: establishment of a new gene therapy strategy using patient derived cell lines
Supervisor
Masters in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/09/16 - Current Dissecting how LAMA2 modulation impact melanoma progression in a 3D in vitro model
Supervisor
Masters in Organismal and Evolutionary Biology (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/09/16 - Current Analysis of the effect of hydrodynamism on the regulation of sea urchin adhesive strength: a molecular and biomechanical approach
Co-supervisor
Masters in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/01 - Current Dissecting the impact of LAMA2-deficiency in melanoma onset and progression
Supervisor
PhD in Biology (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/01 - Current The role of the extracellular environment in cancer
Supervisor of Ana Sofia Lopes
Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/12/01 - Current Disease mechanisms in LAMA2-deficiency: skeletal muscle and heart
Supervisor of Susana Martins
Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2023/09/18 - 2024/11/26 Establishing 3D models to dissect the role of basement membrane-cell communication in cancer
Supervisor
Master Degree in Organismal and Evolutionary Biology (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/18 - 2024/10/14 Understanding how LAMA2 deficiency impacts organ homeostasis
Supervisor
Master in Organismal and Evolutionary Biology (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/19 - 2024/02/20 Understanding the mechanisms at the onset of LAMA2-congenital muscular dystrophy
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/19 - 2024/01/16 Impact of environmental pollutants in the skin: cell physiology and genetic changes
Supervisor
2022/09/19 - 2024/01/12 LAMA2-CMD: establishment of a new gene therapy strategy using an in vitro model
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/19 - 2023/11 Understanding the impact of alterations in the expression of LAMA2 in melanoma
Supervisor
2021/09/01 - 2022/10/18 How Lama2-deficiency impacts myoblast differentiation in a mouse model for LAMA2-congenital muscular dystrophy
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/13 - 2022 Characterizing the impact of LAMA2-deficiency in cancer cell lines
Supervisor of Inês Fonseca
Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/09/07 - 2021/03/08 The impact of Lama2-deficiency on cell cycle regulation and survival
Supervisor of Catarina Melo
Centro de Ecologia Evolução e Alterações Ambientais, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2018/09/01 - 2019/11/30 A protective role for ATM in hemolytic conditions.
Supervisor
Instituto Gulbenkian de Ciência, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2015/11/04 - 2015/11/06 Organization of the Second Annual Joint Postdoctoral Meeting involving the IGC, ITQB, iBET, iMM and Champalimaud, Setubal, Portugal (2015/11/04 - 2015/11/06)
Meeting (Co-organisor)
Instituto Gulbenkian de Ciência, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2020/06/03 - Current Dia Aberto FCUL 2020, 2021
Other
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/05/20 - 2021/05/21 27th Porto Cancer Meeting
Conference
27th Porto Cancer Meeting
2017/04 - 2018/04 Science Outreach Activities: Day of Immunology; practical presentation to the general public.
Other
Instituto Gulbenkian de Ciência, Portugal
2018 - 2018 Science Outreach Activities: Open day of the Instituto Gulbenkian Ciência (IGC), Oeiras, Portugal.
Other
Instituto Gulbenkian de Ciência, Portugal
2010/06 - 2010/06 Science Outreach Activities: Cancer Research UK's Race, Oxford, United Kingdom.
Other
University of Oxford Wolfson College, United Kingdom

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/10/06 Intersectional genetics system for stem cell selection
(Thesis) Main arguer
João Nabo (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/03/30 The role of key post-translational modifications in the nuclear translocation of STAT3 dimers upon cytokine stimulation
(Thesis) Main arguer
Daniela Martins Alves (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/05/08 Estudo da presença de polimosfismo associados à resistência da P. falciparum aos ACTs em Timor Leste.
(Thesis) Main arguer
Patrícia Duarte (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/04/03 Caracterização da miogénese fetal em ratinhos modelo da distrofia muscular laminina 211-deficiente.
(Thesis) Main arguer
Ricardo Andrade (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2022/01/01 - Current European Association for Cancer Research (EACR) Member and Ambassador
2022/01/01 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2021/12/29 - Current COST Action CA20121 Member and co-WG5 leader
2014 - 2016 Science Outreach Activities: Author on the website Mapping Ignorance (http://mappingignorance.org/), promoting scientific writing. Author

Committee member

Activity description
Role
Institution / Organization
2021/06/01 - 2021/07/31 32nd International Biology Olympiad, Scientific Committee
Member
2014/10/01 - 2015/11/01 Member of the postdoc committee at Instituto Gulbenkian Ciência (IGC); Organization of soft skills workshops’ with national and international speakers and the Second Annual Joint Postdoctoral Meeting involving the IGC, ITQB, iBET, iMM and Champalimaud.
Member
Instituto Gulbenkian de Ciência, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/01/08 - Current Invited seminar: Using gene therapy to cure muscle dystrophies (Mestrado) Universidade de Aveiro Instituto de Biomedicina, Portugal
2022/09/05 - Current Animal Physiology (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/07 - Current Physiology - lectures and practical courses https://fenix.ciencias.ulisboa.pt/degrees/bioquimica-564500436615216/disciplina-curricular/564680825249472 Physiology (Bacharelato) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/09/07 - Current Seminars in Evolutionary and Developmental Biology - discussion classes https://fenix.ciencias.ulisboa.pt/courses/sbed-2254879305238640/pagina-inicial Seminars in Evolutionary and Developmental Biology (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/03/04 - Current Genes and Molecules in Development. Lectures and Practical Course. https://fenix.ciencias.ulisboa.pt/courses/gmd-2254879305237611 Genes and Molecules in Development (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/02/27 - Current Animal Development Biology. Lecturer. https://fenix.ciencias.ulisboa.pt/courses/bdani-566029444973860 (Licenciatura) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2016/02/22 - Current Molecular and Cell Biology of Cancer - Genomic Instability and Cancer; Master Degree in Molecular Biology and Genetics, FCUL, Portugal. Invited lecturer. Two hour lecture per year. Molecular and Cell Biology of Cancer (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2013/11/08 - Current Biomolecular Methods - Immunocytochemistry and Immunohistochemistry; Master Degree in Molecular Biology and Genetics. Invited lecturer. Two hour lecture per year. Biomolecular Methods (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/03/08 Women in Science Book 2021 Ciência Viva

Interview (tv / radio show)

Program Topic
2020/10/27 - Current 90 segundos Ciência
2020/02/25 - 2020/02/25 Muito Barulho para Nada

Journal scientific committee

Journal title (ISSN) Publisher
2022/02/01 - Current International Journal of Molecular Sciences MDPI
2021/02/16 - 2021/11/16 Frontiers in Genetics ( 1664-8021) Frontiers
Distinctions

Award

2019 L'Oréal Portugal Medals of Honor for Women in Science 2019
2018 Best poster award: A protective role for ATM in hemolytic conditions
2017 Hugo-Schottmöller Award of the German Sepsis Society, Weimar, Germany
2017 Best Abstract Award International Sepsis Forum, Paris, France
2005 Honorary Degree conferred by the “Fundação da Faculdade de Ciências da Universidade de Lisboa” distinguishing the freshmen with the highest grades of the academic year 2003/2004.
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal