Sandra Isabel Barbosa Marques (2B16-B800-C699)

Curriculum Vitae

Sandra Isabel Barbosa Marques

Identification

Personal identification

Full name: Sandra Isabel Barbosa Marques

Citation names

Marques, Sandra
Marques, S I
Sandra I Marques

Author identifiers

Ciência ID: 2B16-B800-C699
ORCID iD: 0000-0001-8090-5720
Google Scholar ID: eBYYMTEAAAAJ&hl

Knowledge fields

Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2022/12/13 - 2022/12/13 Concluded	Introduction to Data Science (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2021/10/19 - 2021/11/09 Concluded	Estágio Laboratorial de Histologia e Imunohistoquímica (Outros) Universidade do Porto Faculdade de Medicina, Portugal
2019/11/06 - 2019/11/08 Concluded	Course Atomic Force Microscopy applied to Life Sciences (Outros) I3S – INSTITUTO DE INVESTIGAÇÃO E INOVAÇÃO EM SAÚDE, Portugal
2018/09 - 2018/09 Concluded	INTRODUCTION TO DIGITAL IMAGE ANALYSIS WITH IMAGE J/FIJI (Outros) I3S – INSTITUTO DE INVESTIGAÇÃO E INOVAÇÃO EM SAÚDE, Portugal
2018/02 - 2018/05 Concluded	FELASA B (Outros) I3S – INSTITUTO DE INVESTIGAÇÃO E INOVAÇÃO EM SAÚDE, Portugal
2015 Concluded	Terapias Moleculares (Mestrado) Major in Sem especialização Instituto Universitário de Ciências da Saúde, Portugal "Screening and identification of samll molecules with potential antitumour activity and insight into the mechanism of action of a prenylated chalcone in MCF-7 breast cancer cells" (THESIS/DISSERTATION)	16 valores
2015 Concluded	Master degree in Molecular Therapies (Mestrado) Instituto Universitário de Ciências da Saúde, Portugal "Screening and identification of small molecules with potential antitumour activity and insight into the mechanism of action of a prenylated chalcone in MCF-7 breast cancer cells" (THESIS/DISSERTATION)	16
2011 Concluded	Biochemistry (Licenciatura) Instituto Superior de Ciências da Saúde - Norte, CESPU, Portugal "Creation of an stable HeLa cell line expressing a gene for a protein from the mitotic checkpoint" (THESIS/DISSERTATION)	13

Affiliation

Others

	Category Host institution	Employer
2021/01/01 - Current	PhD Student	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2019/11/11 - 2020/12/31	Research Fellow at ICETA/FFUP - H2020-JTI-IMI-2017-13-two-stage, ID 821528	Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal (...)
2018/01/02 - 2019/10/31	Research Fellow in the group Basic and Clinical Research in Iron Biology - Norte2020HOST22	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

2016/06/01 - 2016/08/31	Member of the investigation project : "Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents", leb by Professor	Instituto Universitário de Ciências da Saúded, Portugal

2012/03/01 - 2015/10/28	Master student in Molecular therapies, internship of 2nd year of the course, working in a project under supervision of Professor Doctor Hassan Bousbaa, as dissertation project.	Instituto Universitário de Ciências da Saúde, Portugal

2011/04/01 - 2011/11/01	Trainee researcher in the project “Creating an HeLa cell line expressing an human kinetochore gene”	Instituto Universitário de Ciências da Saúde, Portugal

Projects

Grant

	Designation	Funders
2021/01/01 - Current	Unraveling the involvement of G Protein-coupled receptors in the onset of mood and cognitive adverse events 2020.09080.BD PhD Student Fellow Universidade do Porto Faculdade de Farmácia, Portugal REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Associação para a Inovação e Desenvolvimento da FCT Ongoing

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade NOVA de Lisboa, Portugal INESC Microsistemas e Nanotecnologias, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDB/04378/2020 10.54499/UIDB/04378/2020 Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Journal article

Ana Margarida Araújo; Sandra I. Marques; Paula Guedes de Pinho; Helena Carmo; Félix Carvalho; João Pedro Silva. "Identification of key neuronal mechanisms triggered by dimethyl fumarate in SH-SY5Y human neuroblastoma cells through a metabolomic approach". Archives of Toxicology (2024): https://doi.org/10.1007/s00204-024-03683-9.
10.1007/s00204-024-03683-9
Bárbara Mota; Miguel Ramos; Sandra I. Marques; Ana Silva; Pedro A. Pereira; M. Dulce Madeira; Nuno Mateus; Armando Cardoso. "Effects of High-Fat and High-Fat High-Sugar Diets in the Anxiety, Learning and Memory, and in the Hippocampus Neurogenesis and Neuroinflammation of Aged Rats". Nutrients (2023): https://doi.org/10.3390/nu15061370.
10.3390/nu15061370
Sandra I. Marques; Helena Carmo; Félix Carvalho; Susana I. Sá; João Pedro Silva. "A Semi-Automatic Method for the Quantification of Astrocyte Number and Branching in Bulk Immunohistochemistry Images". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24054508.
10.3390/ijms24054508
Ferreira, A.V.; Duarte, T.L.; Marques, S.; Costa, P.; Neves, S.C.; Santos, T. dos; Granja, P.L.; Porto, G.. "Iron triggers the early stages of cartilage degeneration in vitro: the role of articular chondrocytes". Osteoarthritis and Cartilage Open (2021): 100145. http://dx.doi.org/10.1016/j.ocarto.2021.100145.
10.1016/j.ocarto.2021.100145
Carraro, Maria L.; Marques, Sandra; Silva, Ana Sofia; Freitas, Bruno; Silva, Patrícia M. A.; Pedrosa, Joel; De Marco, Paolo; et al. "Synthesis of New Chiral Derivatives of Xanthones with Enantioselective Effect on Tumor Cell Growth and DNA Crosslinking". ChemistrySelect 5 33 (2020): 10285-10291. http://dx.doi.org/10.1002/slct.202002588.
Marques, Sandra. "Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel". Molecules (2016): http://www.mdpi.com/1420-3049/21/8/982.
10.3390/molecules21080982
Sandra Marques; Joana Fonseca; Patricia Silva; Hassan Bousbaa. "Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment". CCDT 15 4 (2015): 272-281. http://dx.doi.org/10.2174/1568009615666150302130010.
10.2174/1568009615666150302130010
Teixeira JH; Silva PM; Reis RM; Moura IM; Marques S; Fonseca J; Monteiro LS; et al. "An overview of the spindle assembly checkpoint status in oral cancer.". (2014): http://europepmc.org/abstract/med/24995269.
10.1155/2014/145289

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09/12	Astrocyte response in rat brain is affected by pharmacologically-relevant doses of pharmaceuticals associated with neuropsychiatric/psychological adverse events	Eurotox 2023 European Societies of Toxicology (Ljubljana, Slovenia)
2023/02/01	“Protracted administration of pharmacologically relevant doses of paroxetine to rats promotes astrocyte activation in brain regions”	SPF 2023 Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2015/05	A new prenylated chalcone induces mitotic arrest and cell death by mitotic catastrophe in MCF-7 breast cancer. Authors: Marques S., Silva P., Fonseca J., Cidade H., Pinto M. M. and Bousbaa H.	8º Encontro de Jovens Investigadores Universidade do Porto (Porto, Portugal)

Event participation

	Activity description Type of event	Event name Institution / Organization
2016/04/28 - 2016/04/29	Panel Communication ("poster") "A prenylated chalcone acting as an antimitotic agent and inducing catastrophe in human cancer cells" Marques S., Fonseca J., Silva PMA, Pinto MM, Cidade H. and Bousbaa H. Aspic, 2nd International Congress IPO-Porto 28-29 April 2016 Conference	Aspic, 2nd International Congress Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2014/11/26 - 2014/11/28	Panel Communication ("poster") "Assessing the mitotic activity of a new prenylated chalcone in cancer cell lines" Fonseca, J.; Marques, S.; Silva, P.; Cidade, H.; Pinto, M. and Bousbaa, H. Conference	XX Luso- Galego Chemistry Meeting Universidade do Porto Faculdade de Farmácia, Portugal
2014/11/06 - 2014/11/07	Panel Communication ("poster") "Assessing the mitotic activity of a new prenylated chalcone in cancer cell lines' Fonseca, J.; Marques, S.; Silva, P.; Cidade, H.; Pinto, M. and Bousbaa, H. Porto 6-7 November 2014 Conference	INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society. Universidade do Porto, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2016/05/13 - 2016/05/14	Invited Professor for a lecture in "Compound Screening assay: Research for inhibitory activity in Cancer cell lines growth". Presented to the Pharmaceutical Chemistry Masters' class.	(Outros)	Universidade do Porto Faculdade de Farmácia, Portugal

Mentoring / Tutoring

	Topic	Student name
2016/04/01 - 2016/10/01	"Avaliação da actividade anti-tumoral de pequenas moléculas de origem natural e sintética"	Diogo Almeida
2015/01 - 2015/02	“Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama”;	Cristina Sá