António Gil Pereira de Castro (2B14-A625-4C4A)

Curriculum Vitae

António Gil Pereira de Castro

Gil Castro began his scientific career at the Center for Experimental Cytology, University of Porto (1988 – 1994), where he did is PhD. As a postdoctoral researcher he moved to DNAX Research Institute, Palo Alto, CA,USA (1995 – 1998). He then moved to the Gulbenkian Institute for Science (1998 – 2000) to gain knowledge on molecular biology. He then moved to the Institute for Life and Health Sciences, University of Minho (2002 – present). This allowed him to focus his investigation on the immunological mechanism underlying protective/pathologic immune responses to M. tuberculosis. He has published 90 articles in specialized journals. He has received 10 awards and/or honors. He participates and/or participated in 11 projects, 5 of which as a principal investigator. He has already trained more than 30 students between masters and doctoral students.

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Identification

Personal identification

Full name: António Gil Pereira de Castro

Citation names

Castro, Gil

Author identifiers

Ciência ID: 2B14-A625-4C4A
ORCID iD: 0000-0002-4684-4183

Telephones

Telephone

253604815 Ext.: 604815 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Upper intermediate (B2)	Proficiency (C2)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
1996 Concluded	Biologia (Doutoramento) Major in Sem especialidade Universidade do Porto Faculdade de Ciências, Portugal "Citocinas e Regulação da Imunidade Natural e Adquirida na Infecção Experimental do Ratinho por Mycobacterium Avium" (THESIS/DISSERTATION)
1982 - 1987 Concluded	Biologia (Licenciatura) Major in Cientifico Universidade do Porto Faculdade de Ciências, Portugal	13

Affiliation

Science

	Category Host institution	Employer
2003/01/01 - Current	Principal Investigator (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003 - Current	Principal Investigator (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Escola de Medicina, Portugal (...)
2000/09/01 - 2002/07/31	Researcher (Research)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2008 - Current	Associate Professor (University Teacher)	Universidade do Minho, Portugal

2002/09/04 - 2008/03/01	Assistant Professor (University Teacher)	Universidade do Minho, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Positions / Appointments

	Category Host institution	Employer
2020/02/01 - Current	Conselho de escola	Universidade do Minho Escola de Medicina, Portugal

2003/01/02 - 2020/03/02	Conselho científico/técnico-científico ou orgão correspondente	Universidade do Minho Escola de Medicina, Portugal
	Universidade do Minho Escola de Medicina, Portugal
2011/02/01 - 2014/06/01	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Minho, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Others

	Category Host institution	Employer
1998/07/01 - 2000/07/31	Pos-Doc	Instituto Gulbenkian de Ciência, Portugal

1995/01/06 - 1998/05/01	Pos-Doc	Merck Research Laboratories Palo Alto, United States

Projects

Grant

	Designation	Funders
2010 - 2013	BCG vaccination: a tool to identify new correlates of protection and pathology in experimental infection with Mycobacterium tuberculosis PTDC/SAU-MII/101977/2008 Principal investigator	Fundação para a Ciência e Tecnologia
2009 - 2012	Reconstitution and Homeostasis of the Immune System Following HIV-Infection PIC/IC/83313/2007 Principal investigator	Fundação para a Ciência e Tecnologia
2007 - 2010	Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis PTDC/SAU-MII/70895/2006 Principal investigator	Fundação para a Ciência e Tecnologia
2002 - 2004	The Immune Response to Allografts: Role of Anti-inflammatory Cytokines POCTI/MGI/42345/2000 Principal investigator	Fundação para a Ciência e Tecnologia

Contract

	Designation	Funders
2018/06 - 2021/06	Immunological basis of failure in controlling Mycobacterium tuberculosis infection PTDC/SAU-INF/28463/2017 Principal investigator Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Ongoing
2018 - 2021	Microbiota in cancer immunosurveillance: new avenues for immunotherapy PTDC/MED-ONC/28658/2017 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Associação para a Inovação e Desenvolvimento da FCT Ongoing
2017/06 - 2020/05	Immunometabolic Networks in the Regulation of Visceral Leishmaniasis Infect-ERA/0001/2016 Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Ongoing
2014/03/31 - 2017	Deregulation of hematopoiesis by Interleukin-10 over-expression: implications for the development of hematological disorders FCT-ANR/BIM-MEC/0007/2013 Associação para a Inovação e Desenvolvimento da FCT, Portugal Association Francophone Internationale de Recherche Scientifique en Éducation Portugal, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
2009/01/01 - 2012/01/01	Molecular mechanisms regulating the expression of IL-12 cytokines by Mycobacterium tuberculosis infected macrophages and dendritic cells. PTDC/BIA-BCM/102776/2008 Researcher Associação para a Inovação e Desenvolvimento da FCT, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded

Outputs

Publications

Conference paper

Oliveira, J.T.; Picciochi, R.; Santos, T.C.; Malafaya, P.B.; Sousa, R.A.; Marques, A.P.; Castro, A.G.; et al. "Injectable gellan gum hydrogels as supports for cartilage tissue engineering applications: In vitro characterization and initial in vivo studies". 2008.
Santos, T.C.; Tuzlakoglu, K.; Morton, T.; Reise, K.; Marques, A.P.; Castro, A.G.; Redl, H.; Reis, R.L.; Van Griensven, M.. "In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using adipose derived adult stem cells and transgenic mice". 2008.

Journal article

Marne Azarias-da-Silva; pierre nioche; Calaiselvy Soudaramourty; Anne Bull-Maurer; Mounira Tiouajni; kong dechuan; Ouafa Zghidi-Abouzid; et al. "Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13". Science Advances (2023): http://dx.doi.org/10.1126/sciadv.adg2122.
10.1126/sciadv.adg2122
André Santa Cruz; Ana Mendes-Frias; Marne Azarias-da-Silva; Sónia André; Ana Isabel Oliveira; Olga Pires; Marta Mendes; et al. "Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+ß7 integrin+ T cells and anti-SARS-CoV-2 IgA response". Nature Communications (2023): http://dx.doi.org/10.1038/s41467-023-37368-1.
10.1038/s41467-023-37368-1
Paula Roberta Aguiar Pastrez; Ana Margarida Barbosa; Vânia Sammartino Mariano; Rhafaela Lima Causin; Antonio Gil Castro; Egídio Torrado; Longatto-Filho A. "Interleukin-8 and Interleukin-6 Are Biomarkers of Poor Prognosis in Esophageal Squamous Cell Carcinoma". Cancers (2023): http://dx.doi.org/10.3390/cancers15071997.
10.3390/cancers15071997
Daniel Barreira Rodrigues; Helena R. Moreira; Mariana T. Cerqueira; Alexandra P. Marques; António G. Castro; Rui L. Reis; R.P. Pirraco. "Highly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems". Biomaterials Research (2022): http://dx.doi.org/10.1186/s40824-022-00297-z.
10.1186/s40824-022-00297-z
Sonia André; Marne Azarias da Silva; Morgane Picard; Aurélie Alleaume-Buteau; Lucy Kundura; Renaud Cezar; Calaiselvy Soudaramourty; et al. "Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients". Cell Death & Disease (2022): http://dx.doi.org/10.1038/s41419-022-05190-0.
10.1038/s41419-022-05190-0
Catarina M. Ferreira; Consuelo Micheli; Palmira Barreira-Silva; Ana Margarida Barbosa; Mariana Resende; Manuel Vilanova; Ricardo Silvestre; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology (2022): http://dx.doi.org/10.3389/fimmu.2022.946181.
10.3389/fimmu.2022.946181
Alves, A.L.; Costa-Gouveia, J.; Vieira de Castro, J.; Sotelo, C.G.; Vázquez, J.A.; Pérez-Martín, R.I.; Torrado, E.; et al. "Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications". Acta Biomaterialia 141 (2022): 123-131. http://dx.doi.org/10.1016/j.actbio.2022.01.009.
10.1016/j.actbio.2022.01.009
André, Sonia; Picard, Morgane; Cezar, Renaud; Roux-Dalvai, Florence; Alleaume-Butaux, Aurélie; Soundaramourty, Calaiselvy; Cruz, André Santa; et al. "T cell apoptosis characterizes severe Covid-19 disease". Cell Death & Differentiation (2022): http://dx.doi.org/10.1038/s41418-022-00936-x.
10.1038/s41418-022-00936-x
"Immune System Efficiency in Cancer and the Microbiota Influence.". Pathobiology : journal of immunopathology, molecular and cellular biology (2021): https://doi.org/10.1159/000512326.
10.1159/000512326
Cardoso, A.; Martins, A.C.; Maceiras, A.R.; Liu, W.; Castro, I.; Castro, A.G.; Bandeira, A.; et al. "Interleukin-10 induces interferon-¿-dependent emergency myelopoiesis". Cell Reports 37 4 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85119977049&partnerID=MN8TOARS.
10.1016/j.celrep.2021.109887
Ferreira, C.M.; Barbosa, A.M.; Barreira-Silva, P.; Silvestre, R.; Cunha, C.; Carvalho, A.; Rodrigues, F.; et al. "Early IL-10 promotes vasculatureassociated CD4+ T cells unable to control Mycobacterium tuberculosis infection". JCI Insight 6 21 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118899876&partnerID=MN8TOARS.
10.1172/jci.insight.150060
Zamboni, F.; Cengiz, I.F.; Barbosa, A.M.; Castro, A.G.; Reis, R.L.; Oliveira, J.M.; Collins, M.N.. "Towards the development of a female animal model of t1dm using hyaluronic acid nanocoated cell transplantation: Refinements and considerations for future protocols". Pharmaceutics 13 11 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85119622614&partnerID=MN8TOARS.
10.3390/pharmaceutics13111925
Barbosa, A.M.; Martinho, O.; Nogueira, R.; Campos, J.; Lobo, L.; Pinto, H.; Longatto-Filho, A.; et al. "Increased cd3⁺, cd8⁺, or foxp3⁺ t lymphocyte infiltrations are associated with the pathogenesis of colorectal cancer but not with the overall survival of patients". Biology 10 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113948564&partnerID=MN8TOARS.
10.3390/biology10080808
Santa Cruz, A.; Mendes-Frias, A.; Oliveira, A.I.; Dias, L.; Matos, A.R.; Carvalho, A.; Capela, C.; et al. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102130540&partnerID=MN8TOARS.
10.3389/fimmu.2021.613422
"Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes.". Journal of translational autoimmunity (2020): https://europepmc.org/articles/PMC7388368.
10.1016/j.jtauto.2020.100056
"Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production.". Nature communications (2020): https://europepmc.org/articles/PMC7181847.
10.1038/s41467-020-15832-6
Mesquita, Inês; Ferreira, Carolina; Moreira, Diana; Kluck, George Eduardo Gabriel; Barbosa, Ana Margarida; Torrado, Egídio; Dinis-Oliveira, Ricardo Jorge; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. http://dx.doi.org/10.1016/j.celrep.2020.02.098.
10.1016/j.celrep.2020.02.098
"Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization.". Frontiers in immunology (2020): https://europepmc.org/articles/PMC7876410.
10.3389/fimmu.2020.589863
Mariana Resende; Catarina M. Ferreira; Ana Margarida Barbosa; Marcos S. Cardoso; Jeremy Sousa; Margarida Saraiva; António G. Castro; Rui Appelberg; Egídio Torrado. "Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection". Immunology 159 1 (2020): 121-129. https://doi.org/10.1111/imm.13131.
10.1111/imm.13131
Resende, M.; Cardoso, M.S.; Fróis-Martins, R.; Borges, M.; Jordan, M.B.; Castro, A.G.; Appelberg, R.. "TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-¿". Journal of Immunology 203 9 (2019): 2451-2458. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073667502&partnerID=MN8TOARS.
10.4049/jimmunol.1801594
Meira, L.; Chaves, C.; Araújo, D.; Almeida, L.; Boaventura, R.; Ramos, A.; Carvalho, T.; et al. "Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting". Pulmonology 25 6 (2019): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061974321&partnerID=MN8TOARS.
10.1016/j.pulmoe.2018.11.001
Fraga, A.G.; Trigo, G.; Murthy, R.K.; Akhtar, S.; Hebbur, M.; Pacheco, A.R.; Dominguez, J.; et al. "Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection". PLoS Neglected Tropical Diseases 13 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071832074&partnerID=MN8TOARS.
10.1371/journal.pntd.0007113
Castro, Gil. "The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis". Cytokine (2018): http://dx.doi.org/10.1016/j.cyto.2018.07.001.
10.1016/j.cyto.2018.07.001
Castro, Gil. "A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis". mSphere (2018): http://dx.doi.org/10.1128/msphere.00352-18.
10.1128/msphere.00352-18
Castro, Gil. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery". Frontiers in Physiology (2018): http://dx.doi.org/10.3389/fphys.2018.01247.
10.3389/fphys.2018.01247
Castro, Gil. "The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis". Frontiers in Immunology (2018): http://dx.doi.org/10.3389/fimmu.2018.00400.
10.3389/fimmu.2018.00400
Silva, E.M.; Mariano, V.S.; Aguiar Pastrez, P.R.; Pinto, M.C.; Castro, A.G.; Syrjanen, K.J.; Longatto-Filho, A.. "High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer". PLoS ONE 12 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85024483810&partnerID=MN8TOARS.
10.1371/journal.pone.0181125
Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
10.1016/j.jaci.2017.02.034
Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia". GLIA 65 9 (2017): 1439-1451. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021258982&partnerID=MN8TOARS.
10.1002/glia.23172
Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Balancing the immune response in the brain: IL-10 and its regulation". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997106994&partnerID=MN8TOARS.
10.1186/s12974-016-0763-8
Bastos, H.N.; Osório, N.S.; Castro, A.G.; Ramos, A.; Carvalho, T.; Meira, L.; Araújo, D.; et al. "A prediction rule to stratify mortality risk of patients with pulmonary tuberculosis". PLoS ONE 11 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992386220&partnerID=MN8TOARS.
10.1371/journal.pone.0162797
Silva, J.P.; Gonçalves, C.; Costa, C.; Sousa, J.; Silva-Gomes, R.; Castro, A.G.; Pedrosa, J.; Appelberg, R.; Gama, F.M.. "Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment". Journal of Controlled Release 235 (2016): 112-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973165158&partnerID=MN8TOARS.
10.1016/j.jconrel.2016.05.064
Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
10.4049/jimmunol.1600584
Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
10.1016/j.vaccine.2014.11.013
Silva-Gomes, R.; Marcq, E.; Trigo, G.; Gonçalves, C.M.; Longatto-Filho, A.; Castro, A.G.; Pedrosa, J.; Fraga, A.G.. "Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model". PLoS Neglected Tropical Diseases 9 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84953274374&partnerID=MN8TOARS.
10.1371/journal.pntd.0004265
Cardoso, F.; Castro, F.; Moreira-Teixeira, L.; Sousa, J.; Torrado, E.; Silvestre, R.; Castro, A.G.; Saraiva, M.; Pais, T.F.. "Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940426429&partnerID=MN8TOARS.
10.1371/journal.pone.0131904
Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
10.3389/fimmu.2015.00498
Carvalho, A.; Costa, P.; Triunfante, V.; Branca, F.; Rodrigues, F.; Santos, C.L.; Correia-Neves, M.; et al. "Analysis of a local HIV-1 epidemic in portugal highlights established transmission of Non-B and Non-G subtypes". Journal of Clinical Microbiology 53 5 (2015): 1506-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928032043&partnerID=MN8TOARS.
10.1128/JCM.03611-14
Teixeira-Coelho, M.; Guedes, J.; Ferreirinha, P.; Howes, A.; Pedrosa, J.; Rodrigues, F.; Lai, W.S.; et al. "Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages". European Journal of Immunology 44 3 (2014): 856-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030127&partnerID=MN8TOARS.
10.1002/eji.201343734
Santos, T.C.; Höring, B.; Reise, K.; Marques, A.P.; Silva, S.S.; Oliveira, J.M.; Mano, J.F.; et al. "In vivo performance of chitosan/soy-based membranes as wound-dressing devices for acute skin wounds". Tissue Engineering - Part A 19 7-8 (2013): 860-869. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874732614&partnerID=MN8TOARS.
10.1089/ten.tea.2011.0651
Menino, J.F.; Saraiva, M.; Gomes-Rezende, J.; Sturme, M.; Pedrosa, J.; Castro, A.G.; Ludovico, P.; Goldman, G.H.; Rodrigues, F.. "P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884191896&partnerID=MN8TOARS.
10.1371/journal.pone.0074725
Carmona, J.; Cruz, A.; Moreira-Teixeira, L.; Sousa, C.; Sousa, J.; Osorio, N.S.; Saraiva, A.L.; et al. "Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879468975&partnerID=MN8TOARS.
10.1371/journal.pone.0067277
Horta, A.; Nobrega, C.; Amorim-Machado, P.; Coutinho-Teixeira, V.; Barreira-Silva, P.; Boavida, S.; Costa, P.; et al. "Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4+ T Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874234588&partnerID=MN8TOARS.
10.1371/journal.pone.0057336
Trigo, G.; Martins, T.G.; Fraga, A.G.; Longatto-Filho, A.; Castro, A.G.; Azeredo, J.; Pedrosa, J.. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model". PLoS Neglected Tropical Diseases 7 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876876365&partnerID=MN8TOARS.
10.1371/journal.pntd.0002183
Menino, J.F.; Saraiva, M.; Gomes-Alves, A.G.; Lobo-Silva, D.; Sturme, M.; Gomes-Rezende, J.; Saraiva, A.L.; et al. "TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival". PLoS Neglected Tropical Diseases 7 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880846173&partnerID=MN8TOARS.
10.1371/journal.pntd.0002317
Rada, T.; Carvalho, P.P.; Santos, T.C.; Castro, A.G.; Reis, R.L.; Gomes, M.E.. "Chondrogenic potential of two hASCs subpopulations loaded onto gellan gum hydrogel evaluated in a nude mice model". Current Stem Cell Research and Therapy 8 5 (2013): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888089078&partnerID=MN8TOARS.
10.2174/1574888X113089990049
Osório, N.S.; Rodrigues, F.; Gagneux, S.; Pedrosa, J.; Pinto-Carbó, M.; Castro, A.G.; Young, D.; Comas, I.; Saraiva, M.. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure". Molecular Biology and Evolution 30 6 (2013): 1326-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727980&partnerID=MN8TOARS.
10.1093/molbev/mst038
Santos, T.C.; Morton, T.J.; Moritz, M.; Pfeifer, S.; Reise, K.; Marques, A.P.; Castro, A.G.; Reis, R.L.; Van Griensven, M.. "Vascular endothelial growth factor and fibroblast growth factor-2 incorporation in starch-based bone tissue-engineered constructs promote the in vivo expression of neovascularization mediators". Tissue Engineering - Part A 19 7-8 (2013): 834-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874685019&partnerID=MN8TOARS.
10.1089/ten.tea.2010.0741
Fraga, A.G.; Martins, T.G.; Torrado, E.; Huygen, K.; Portaels, F.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Cellular immunity confers transient protection in experimental buruli ulcer following BCG or mycolactone-negative mycobacterium ulcerans vaccination". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857837898&partnerID=MN8TOARS.
10.1371/journal.pone.0033406
Mishra, A.K.; Alves, J.E.; Krumbach, K.; Nigou, J.; Castro, A.G.; Geurtsen, J.; Eggeling, L.; Saraiva, M.; Besra, G.S.. "Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation". Journal of Biological Chemistry 287 53 (2012): 44173-44183. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871782017&partnerID=MN8TOARS.
10.1074/jbc.M112.402396
Martins, T.G.; Trigo, G.; Fraga, A.G.; Gama, J.B.; Longatto-Filho, A.; Saraiva, M.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection". PLoS Neglected Tropical Diseases 6 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870754979&partnerID=MN8TOARS.
10.1371/journal.pntd.0001925
Rada, T.; Santos, T.C.; Marques, A.P.; Correlo, V.M.; Frias, A.M.; Castro, A.G.; Neves, N.M.; Gomes, M.E.; Reis, R.L.. "Osteogenic differentiation of two distinct subpopulations of human adipose-derived stem cells: An in vitro and in vivo study". Journal of Tissue Engineering and Regenerative Medicine 6 1 (2012): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855338090&partnerID=MN8TOARS.
10.1002/term.388
Martins, T.G.; Gama, J.B.; Fraga, A.G.; Saraiva, M.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Local and regional re-establishment of cellular immunity during curative antibiotherapy of murine mycobacterium ulcerans infection". PLoS ONE 7 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857676432&partnerID=MN8TOARS.
10.1371/journal.pone.0032740
Carvalho, A.; Cunha, C.; Almeida, A.J.; Osório, N.S.; Saraiva, M.; Teixeira-Coelho, M.; Pedreiro, S.; et al. "The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma". Genes and Immunity 13 2 (2012): 197-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857787435&partnerID=MN8TOARS.
10.1038/gene.2011.59
Carvalho, A.; Osório, N.S.; Saraiva, M.; Cunha, C.; Almeida, A.J.; Teixeira-Coelho, M.; Ludovico, P.; et al. "The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation". PLoS ONE 6 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-81755184094&partnerID=MN8TOARS.
10.1371/journal.pone.0028256
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10.1093/intimm/dxq459
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10.1128/IAI.00820-10
Santos, T.C.; Marques, A.P.; Silva, S.S.; Oliveira, J.M.; Mano, J.F.; Castro, A.G.; Van Griensven, M.; Reis, R.L.. "Chitosan improves the biological performance of soy-based biomaterials". Tissue Engineering - Part A 16 9 (2010): 2883-2890. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956069691&partnerID=MN8TOARS.
10.1089/ten.tea.2010.0114
Oliveira, J.T.; Santos, T.C.; Martins, L.; Picciochi, R.; Marques, A.P.; Castro, A.G.; Neves, N.M.; Mano, J.F.; Reis, R.L.. "Gellan gum injectable hydrogels for cartilage tissue engineering applications: In vitro studies and preliminary in vivo evaluation". Tissue Engineering - Part A 16 1 (2010): 343-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-77049090031&partnerID=MN8TOARS.
10.1089/ten.tea.2009.0117
Nobrega, C.; Roque, S.; Nunes-Alves, C.; Coelho, A.; Medeiros, I.; Castro, A.G.; Appelberg, R.; Correia-Neves, M.. "Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen". Journal of Immunology 184 1 (2010): 351-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949157248&partnerID=MN8TOARS.
10.4049/jimmunol.0902152
Santos, T.C.; Marques, A.P.; Höring, B.; Martins, A.R.; Tuzlakoglu, K.; Castro, A.G.; Van Griensven, M.; Reis, R.L.. "In vivo short-term and long-term host reaction to starch-based scaffolds". Acta Biomaterialia 6 11 (2010): 4314-4326. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956927444&partnerID=MN8TOARS.
10.1016/j.actbio.2010.06.020
Torrado, E.; Fraga, A.G.; Logarinho, E.; Martins, T.G.; Carmona, J.A.; Gama, J.B.; Carvalho, M.A.; et al. "IFN-¿-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone". Journal of Immunology 184 2 (2010): 947-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249087225&partnerID=MN8TOARS.
10.4049/jimmunol.0902717
Teixeira, L.; Botelho, A.S.; Mesquita, S.D.; Correia, A.; Cerca, F.; Costa, R.; Sampaio, P.; Castro, A.G.; Vilanova, M.. "Plasmacytoid and conventional dendritic cells are early producers of IL-12 in Neospora caninum-infected mice". Immunology and Cell Biology 88 1 (2010): 79-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-74249110613&partnerID=MN8TOARS.
10.1038/icb.2009.65
Cruz, A.; Fraga, A.G.; Fountain, J.J.; Rangel-Moreno, J.; Torrado, E.; Saraiva, M.; Pereira, D.R.; et al. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis". Journal of Experimental Medicine 207 8 (2010): 1609-1616. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955390095&partnerID=MN8TOARS.
10.1084/jem.20100265
Lima-Rodrigues, M.; Lamas, N.; Valle-Fernandes, A.; Cruz, A.; Vieira, A.; Oliveira, P.; Pedrosa, J.; et al. "The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment". Inflammation Research 59 9 (2010): 743-753. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955652845&partnerID=MN8TOARS.
10.1007/s00011-010-0185-5
Sampaio, P.; Santos, M.; Correia, A.; Amaral, F.E.; Chavéz-Galarza, J.; Costa-de-Oliveira, S.; Castro, A.G.; Pedrosa, J.; Pais, C.. "Virulence attenuation of Candida albicans genetic variants isolated from a patient with a recurrent bloodstream infection". PLoS ONE 5 4 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956304308&partnerID=MN8TOARS.
10.1371/journal.pone.0010155
Almeida, A.J.; Cunha, C.; Carmona, J.A.; Sampaio-Marques, B.; Carvalho, A.; Malavazi, I.; Steensma, H.Y.; et al. "Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis". Fungal Genetics and Biology 46 12 (2009): 919-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350408790&partnerID=MN8TOARS.
10.1016/j.fgb.2009.08.004
Oliveira, J.T.; Santos, T.C.; Martins, L.; Silva, M.A.; Marques, A.P.; Castro, A.G.; Neves, N.M.; Reis, R.L.. "Performance of new gellan gum hydrogels combined with human articular chondrocytes for cartilage regeneration when subcutaneously implanted in nude mice". Journal of Tissue Engineering and Regenerative Medicine 3 7 (2009): 493-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449131501&partnerID=MN8TOARS.
10.1002/term.184
Gaspar, M.M.; Cruz, A.; Fraga, A.G.; Castro, A.G.; Cruz, M.E.M.; Pedrosa, J.. "Developments on drug delivery systems for the treatment of mycobacterial infections". Current Topics in Medicinal Chemistry 8 7 (2008): 579-591. http://www.scopus.com/inward/record.url?eid=2-s2.0-44949217601&partnerID=MN8TOARS.
10.2174/156802608783955629
Lima-Rodrigues, M.; Valle-Fernandes, A.; Lamas, N.; Cruz, A.; Baltazar, F.; Milanezi, F.; Nunes, R.; et al. "A new model of laryngitis: Neuropeptide, cyclooxygenase, and cytokine profile". Laryngoscope 118 1 (2008): 78-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549072217&partnerID=MN8TOARS.
10.1097/MLG.0b013e3181492400
Mesquita, A.R.; Correia-Neves, M.; Roque, S.; Castro, A.G.; Vieira, P.; Pedrosa, J.; Palha, J.A.; Sousa, N.. "IL-10 modulates depressive-like behavior". Journal of Psychiatric Research 43 2 (2008): 89-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849117677&partnerID=MN8TOARS.
10.1016/j.jpsychires.2008.02.004
Portaels, F.; Meyers, W.M.; Ablordey, A.; Castro, A.G.; Chemlal, K.; de Rijk, P.; Elsen, P.; et al. "First cultivation and characterization of Mycobacterium ulcerans from the environment". PLoS Neglected Tropical Diseases 2 3 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-48949118021&partnerID=MN8TOARS.
10.1371/journal.pntd.0000178
O'Garra, A.; Barrat, F.J.; Castro, A.G.; Vicari, A.; Hawrylowicz, C.. "Strategies for use of IL-10 or its antagonists in human disease". Immunological Reviews 223 1 (2008): 114-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-47249134619&partnerID=MN8TOARS.
10.1111/j.1600-065X.2008.00635.x
Teixeira, L.; Botelho, A.S.; Batista, A.R.; Meireles, C.S.; Ribeiro, A.; Domingues, H.S.; Correia Da Costa, J.M.; et al. "Analysis of the immune response to Neospora caninum in a model of intragastric infection in mice". Parasite Immunology 29 1 (2007): 23-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845584829&partnerID=MN8TOARS.
10.1111/j.1365-3024.2006.00911.x
Santos, T.C.; Marques, A.P.; Silva, S.S.; Oliveira, J.M.; Mano, J.F.; Castro, A.G.; Reis, R.L.. "In vitro evaluation of the behaviour of human polymorphonuclear neutrophils in direct contact with chitosan-based membranes". Journal of Biotechnology 132 2 (2007): 218-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349023267&partnerID=MN8TOARS.
10.1016/j.jbiotec.2007.07.497
Torrado, E.; Fraga, A.G.; Castro, A.G.; Stragier, P.; Meyers, W.M.; Portaels, F.; Silva, M.T.; Pedrosa, J.. "Evidence for an intramacrophage growth phase of Mycobacterium ulcerans". Infection and Immunity 75 2 (2007): 977-987. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846781153&partnerID=MN8TOARS.
10.1128/IAI.00889-06
Botelho, A.S.; Teixeira, L.; Correia-da-Costa, J.M.; Faustino, A.M.R.; Castro, A.G.; Vilanova, M.. "Neospora caninum: High susceptibility to the parasite in C57BL/10ScCr mice". Experimental Parasitology 115 1 (2007): 68-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751166574&partnerID=MN8TOARS.
10.1016/j.exppara.2006.06.004
Torrado, E.; Adusumilli, S.; Fraga, A.G.; Small, P.L.C.; Castro, A.G.; Pedrosa, J.. "Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection". Infection and Immunity 75 8 (2007): 3979-3988. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547624336&partnerID=MN8TOARS.
10.1128/IAI.00290-07
Cruz, A.; Khader, S.A.; Torrado, E.; Fraga, A.; Pearl, J.E.; Pedrosa, J.; Cooper, A.M.; Castro, A.G.. "Cutting edge: IFN-¿ regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection". Journal of Immunology 177 3 (2006): 1416-1420. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746215298&partnerID=MN8TOARS.
Neighbors, M.; Hartley, S.B.; Xu, X.; Castro, A.G.; Bouley, D.M.; O'Garra, A.. "Breakpoints in immunoregulation required for Th1 cells to induce diabetes". European Journal of Immunology 36 9 (2006): 2315-2323. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748859399&partnerID=MN8TOARS.
10.1002/eji.200636432
Oliveira, M.S.; Fraga, A.G.; Torrado, E.; Castro, A.G.; Pereira, J.P.; Longatto Filho, A.; Milanezi, F.; et al. "Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice". Infection and Immunity 73 10 (2005): 6299-6310. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444518934&partnerID=MN8TOARS.
10.1128/IAI.73.10.6299-6310.2005
Castro, A.G.; Neighbors, M.; Hurst, S.D.; Zonin, F.; Silva, R.A.; Murphy, E.; Liu, Y.-J.; O'Garra, A.. "Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide". Journal of Experimental Medicine 192 10 (2000): 1529-1534. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034694028&partnerID=MN8TOARS.
10.1084/jem.192.10.1529
Castro, A.G.; Hauser, T.M.; Cocks, B.G.; Abrams, J.; Zurawski, S.; Churakova, T.; Zonin, F.; et al. "Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): Differential expression and responsiveness in Th1 and Th2 cells". Journal of Immunology 163 11 (1999): 5860-5870. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033485397&partnerID=MN8TOARS.
Appelberg, R.; Castro, A.G.; Gomes, S.; Pedrosa, J.; Silva, M.T.. "Susceptibility of beige mice to Mycobacterium avium: Role of neutrophils". Infection and Immunity 63 9 (1995): 3381-3387. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029121416&partnerID=MN8TOARS.
Castro, A.G.; Silva, R.A.; Minoprio, P.; Appelberg, R.. "In vivo evidence for a non-T cell origin of interleukin-5". Scandinavian Journal of Immunology 41 3 (1995): 288-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028954076&partnerID=MN8TOARS.
10.1111/j.1365-3083.1995.tb03566.x
Castro, A.G.; Silva, R.A.; Appelberg, R.. "Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice". Journal of Immunology 155 4 (1995): 2013-2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029162723&partnerID=MN8TOARS.
Appelberg, R.; Sarmento, A.; Castro, A.G.. "Tumour necrosis factor-alpha (TNF-a) in the host resistance to mycobacteria of distinct virulence". Clinical and Experimental Immunology 101 2 (1995): 308-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029085639&partnerID=MN8TOARS.
Castro, A.G.; Minoprio, P.; Appelberg, R.. "The relative impact of bacterial virulence and host genetic background on cytokine expression during Mycobacterium avium infection of mice". Immunology 85 4 (1995): 556-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029148250&partnerID=MN8TOARS.
Appelberg, R.; Castro, A.G.; Pedrosa, J.; Silva, R.A.; Orme, I.M.; Minoprio, P.. "Erratum: Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection (Infection and Immunity 62:9 (3969))". Infection and Immunity 63 3 (1995): 1145-1145. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028903155&partnerID=MN8TOARS.
Pedrosa, J.; Florido, M.; Kunze, Z.M.; Castro, A.G.; Portaels, F.; McFadden, J.; Silva, M.T.; Appelberg, R.. "Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice". Clinical and Experimental Immunology 98 2 (1994): 210-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028062985&partnerID=MN8TOARS.
Appelberg, R.; Castro, A.G.; Pedrosa, J.; Minoprio, P.. "Role of interleukin-6 in the induction of protective T cells during mycobacterial infections in mice". Immunology 82 3 (1994): 361-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028103903&partnerID=MN8TOARS.
Appelberg, R.; Castro, A.G.; Pedrosa, J.; Silva, R.A.; Orme, I.M.; Minoprio, P.. "Role of gamma interferon and tumor necrosis factor alpha during T-cell- independent and -dependent phases of Mycobacterium avium infection". Infection and Immunity 62 9 (1994): 3962-3971. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028142783&partnerID=MN8TOARS.
Appelberg, R.; Castro, A.G.; Silva, M.T.. "Neutrophils as effector cells of T-cell-mediated, acquired immunity in murine listeriosis". Immunology 83 2 (1994): 302-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028139111&partnerID=MN8TOARS.
Castro, A.G.; Esaguy, N.; Macedo, P.M.; Aguas, A.P.; Silva, M.T.. "Live but not heat-killed mycobacteria cause rapid chemotaxis of large numbers of eosinophils in vivo and are ingested by the attracted granulocytes". Infection and Immunity 59 9 (1991): 3009-3014. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025912452&partnerID=MN8TOARS.

Other

Other output

Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection. 2018. Fraga, A.G.; Trigo, G.; Dominguez, J.; Silva-Gomes, R.; Gonçalves, C.M.; Hugo, O.; Castro, A.G.; Azeredo, J.; Pedrosa, J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092863359&partnerID=MN8TOARS.
10.1101/507129

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2017 - Current	Epigenetics and Genetics of Hematopoietic Stem Cells Heterogeneity Co-supervisor	Instituto Gulbenkian de Ciência, Portugal
2017 - Current	Production, characterization and functionalization of dendronized polymers as aAPC systems Co-supervisor	Universidade do Minho - Campus de Azurém, Portugal
2017 - Current	Dissecting the immunometabolic crosstalk of IL-17A/F-induced macrophage reprogramming during infection Co-supervisor	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012 - 2017	Assembly of granulomas during mycobacterial infections in mice: cellular and molecular dynamics Supervisor	Universidade do Minho Escola de Medicina, Portugal
2009 - 2016	Polyssacharide-based nanogels: novel tackling and treating approach of non-small cancer lung cells Co-supervisor	Universidade do Minho Escola de Engenharia, Portugal
2013 - 2014	Impact of IL-10 and SIRT-2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections Supervisor	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2013	Paracoccidioides brasiliensis: virulence factors and host susceptibility Co-supervisor	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2013	Characterization of the immune response following infection by multi-drug-resistant strains of Mycobacterium tuberculosis Supervisor	Universidade do Minho Escola de Medicina, Portugal
2007 - 2012	Impact of mycobacterial recognition by toll like receptors in the regulation of IL-10 and T helper type of responses Supervisor	Universidade do Minho Escola de Medicina, Portugal
2010 - 2011	Regulatory CD4+ T cells in the immune system homeostasis of HIV-infected patients under anti-retroviral therapy Supervisor
2010 - 2011	Importance of TLR2 on recognition and IL-17 presence on the innate immune responses to mycobacteria Supervisor	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2010	Understanding Buruli Ulcer: Elucidation of the cellular and molecular mechanisms underlying infection with Mycobacterium ulcerans Co-supervisor	Universidade do Minho Escola de Medicina, Portugal
2004 - 2009	In vivo performance and assessment of inflammatory response to starch-based scaffolds for tissue engineering Co-supervisor	Universidade do Minho, Portugal
2003 - 2006	Understanding BCG vaccination: implications for the design of new preventive strategies against mycobacteriosis Supervisor	Universidade do Minho Escola de Medicina, Portugal
2004 - 2005	Prevenção das parasitoses gastrintestinais – de transmissão fecal-oral Supervisor	Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019 - 2019	Research Seminar “The frontiers of research in ILD (2019 - 2019) Conference (Member of the Organising Committee)
2019 - 2019	XII Minho Medical Meeting (2019 - 2019) Meeting (Member of the Scientific Committee)	Universidade do Minho Escola de Medicina, Portugal
2015 - 2015	XLI Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “From basic Immunology to the latest clinical breakthrough (2015 - 2015) Congress (Member of the Organising Committee)	Universidade do Minho Escola de Medicina, Portugal
2010 - 2010	XXXVI Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “Fighting Intracellular Pathogens: from bench to bedside (2010 - 2010) Congress (Member of the Organising Committee)
2006 - 2006	XXXII Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “Innate and Acquired Immunity: evolution and regulation” (2006 - 2006) Congress (Member of the Organising Committee)	Universidade do Minho Escola de Medicina, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2018/05/23	Sensing and transcriptional requirements of innate lymphoid cells (Thesis) Main arguer	Rita Gomes Domingues (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2016	Mechanisms of action and antimycobacterial activity of antimicrobial peptides (Thesis) Main arguer	Tânia Martins da Silva (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/12/17	Towards the therapeutic use of regulatory T cells for the treatment of human autoimmune diseases (Thesis) Main arguer	Maria Catarina Mota da Silva (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2015/07/13	Immunoglobulin, somatic hypermutation and the survival of B cells (Thesis) Main arguer	Pedro José Ponce de Leão de Azevedo Geraldes (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2015/06/29	Cationic liposomes as antigen delivery systems: developemnt of na immunoprotective strategy against Candida albicans (Thesis) Main arguer	Maria Catarina Santos Carneiro (PhD) Universidade do Minho Departamento de Biologia, Portugal
2014	Macrophage-Mycobacterium avium subsp. paratuberculosis interplay in inflammatory bowel disease: possible immunopathological implications (Thesis) Main arguer	Nair Alexandra Barbosa Nazareth Campos (PhD) Universidade do Porto Faculdade de Medicina, Portugal
2013/11/21	Unravel key elements of tissue engineering constructs in the route to skin regeneration (Thesis) Main arguer	MarianaTeixeira Cerqueira (PhD) Universidade do Minho Centro de Engenharia Biológica, Portugal
2013/10/16	The immune response to mycobacteria of distinct virulence (Thesis) Main arguer	Manuel António Afonso Pereira Barroso (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/01/25	Impact of immunomodulatory proteins: at the level of the cell and the whole animal (Thesis) Main arguer	Vivian Leite de Oliveira (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/03/16	The Leishmania TDR1 family-related gene: functional studies and evaluation of TDR1 recombinant protein as a vaccine against leishmaniasis (Thesis) Main arguer	Ana Marta Franco da Silva (PhD) Universidade do Porto Faculdade de Farmácia, Portugal
2011	Co-cultures and cell sheet engineering as relevant tools to improve the outcome of bone tissue engineering strategies (Thesis) Arguer	Rogério Pedro Lemos de Sousa Pirraco (PhD) Universidade do Minho Escola de Engenharia, Portugal
2010	CD38 and Immune function: role of infections by intracellular bacteria and systemic autoimmunity (Thesis) Main arguer	Marta Susana de Almeida Viegas da Silva (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010	On the origin of Human CD8+ NK-like T cells: a role for IL-15 and hepatocytes? (Thesis) Main arguer	Margareta Isabel Pereira Correia (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009	Modulação de células dendriticas e monócitos pelo vírus da imunodeficiência Humana tipo 2 (Thesis) Main arguer	Rita Jorge Dias Cavaleiro (PhD) Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
2008	The role of antigen presenting cells in immune regulation mediated by regulatory T cells (Thesis) Main arguer	Andreia Cristina Leitão Correia Simão Lino (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006	GFP Tagged IL-10 Knock-in Mice (Thesis) Main arguer	Dinis Pedro Parente Calado (PhD) Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
2005	Inflammatory responses to biomaterials: interactions between leukocytes and self-assembled monolayers (Thesis) Main arguer	Maria Judite Tavares Moreira Novais Barbosa (PhD) Universidade do Porto Faculdade de Engenharia, Portugal
2004	Clonagem e caracterização de proteínas imunomoduladoras de Streptococcus sobrinus (Thesis) Arguer	Isabel Vicência Franco Campos Matias da Veiga Malta (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2004	Regulatory CD4 T cell function and dynamics in inflammation (Thesis) Main arguer	Íris Maria Ferreira Caramalho (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001	Modulação da resposta imunológica do ratinho à infecção pelo Mycobacterium avium: papel da IL-10 e da IL-12 em estratégias de imunomodulação, vacinação e quimioterapia Thesis Member	Regina Augusta Alves Pereira da Silva (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001	Cytokines as potential co-adjuvants in a subunit vaccine against tuberculosis (Thesis) Arguer	Irene Sofia Leal (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000	Protecção por neutrófilos nas infecções murinas por Mycobacterium tuberculosis e Mycobacterium avium: uma actividade não-fagocítica de um fagócito profissional (Thesis) Arguer	Jorge Pedrosa (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000	Interacção do Mycobacterium avium com o macrófago em apoptose Thesis Member	Teresa Faria Pais (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000	Interacção Mycobacterium avium – hospedeiro: factores de virulência e mecanismos de resistência Thesis Member	Manuela Florido (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

	Society Organization name	Role
1998 - Current	Sociedade Portuguesa de Imunologia	Sócio e Presidente Conselho Fiscal

Consulting

	Activity description	Institution / Organization
2019 - 2019	Graduate woman in science

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2019 - Current	Membro de painel de avaliação do Concurso de Bolsas de Doutoramento Evaluator	Associação para a Inovação e Desenvolvimento da FCT, Portugal	Associação para a Inovação e Desenvolvimento da FCT

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2011	Prémio Pulido Valente Ciência atribuído a estudo da UMinho	UMDicas
2011	Revacinação com BCG pode ter "efeito maléfico"	Jornal Noticias

Interview (tv / radio show)

	Program	Topic
2011 - 2011	SIC Noticias	Investigação: Estudo da Universidade do Minho recebe Prémio Pulido Valente Ciência 2010
2011 - 2011	RTP Noticias	Revacinação com BCG pode ser negativa

Journal scientific committee

	Journal title (ISSN)	Publisher
2011 - Current	Frontiers in Immunology (1664-3224)	Frontiers Media SA

Distinctions

Award

2010	SPI Best Paper Award Sociedade Portuguesa de Imunologia, Portugal
2010	Prémio Pulido Valente Ciência
2006	Prémio de Excelência em Imunologia Mário Arala Chaves Sociedade Portuguesa de Imunologia, Portugal
1994	Prémio Pfizer Pfizer Portugal, Portugal