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Identification

Personal identification

Full name
Maria Alexandra da Silva Paulo

Citation names

  • Paulo, Alexandra

Author identifiers

Ciência ID
2B13-DA6F-229F
ORCID iD
0000-0003-1433-5402

Email addresses

  • mapaulo@ff.ul.pt (Professional)
  • mapaulo@ff.ulisboa.pt (Professional)

Telephones

Telephone
  • 217946473 (Professional)

Addresses

  • Faculdade de Farmácia da Universidade de Lisboa. Av. Prof. Gama Pinto, 1649 003, Lisboa, Lisboa, Portugal (Professional)
  • iMed.ULisboa, Research Institute of Medicines, Faculty of Pharmacy, University of Lisbon, 1649 003, Lisbon, Lisbon, Portugal (Professional)

Websites

  • ORCID ID: 0000-0003-1433-5402 (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Advanced (C1) Beginner (A1) Beginner (A1)
Spanish; Castilian Advanced (C1)
Education
Degree Classification
2014
Concluded
Pharmacy (medicinal chemistry) (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
unanimidade
1998
Concluded
Pharmacy (Doctor of Philosophy)
University of London, United Kingdom
"Chemical and biological studies on african Cryptolepis species" (THESIS/DISSERTATION)
Aprovado
1990
Concluded
Pharmaceutical Sciences (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"not applicable" (THESIS/DISSERTATION)
16/20
Affiliation

Science

Category
Host institution
Employer
2007/01/01 - Current Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
1998 - 2007 Researcher (Research) Centro de Estudos Ciências Farmacêuticas / FFUL, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution
Employer
1998/06/02 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution
Employer
1991/07/01 - 1998/07/02 Researcher and Teaching Assistant Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2021 - 2024/03/28 Targeting mutant p53 with tryptophanol-derived small molecules
PTDC/QUI-QOR/1304/2020
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021/09 A new approach to fight tuberculosis: co-drugs activated by mycobacterial esterases
PTDC/SAU-INF/28080/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018 - 2021/08 DRUG DISCOVERY FOR p53 PPI-TARGETS
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2020 POINT4PAC - Precision Oncology by Innovative Therapies and Technologies
SAICTPAC/0019/2015
Researcher
COMPETE and FCT through PROGRAMAS DE ATIVIDADES CONJUNTAS (PAC)
2013 - 2014/12 Exploring a new approach to target KRAS oncogene
EXPL/QEQ-MED/0502/2012
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014/08 TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS
PTDC/SAU-FAR/114864/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Paulo, A.; Castillo, C.C.; Neidle, S.. "Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy". In Comprehensive Medicinal Chemistry III, edited by Chakalamannil, S; Rotella, DP; Ward, SE., 308-340. United Kingdom: Elsevier, 2017.
    Published • 10.1016/b978-0-12-409547-2.12397-2
  2. Lavrado J, et al; Paulo, Alexandra. "133. Synthesis of indolo(3,2-b)quinolin-11-one by acid-calalysed intramolecular double cyclization". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 585-589. The Royal Society of Chemistry, 2016.
    Published
  3. Lavrado, J. et al; Paulo, Alexandra. "138. Benzotriazole, a useful synthetic auxiliary in heterocyclizations". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 609-612. The Royal Society of Chemistry, 2016.
    Published
  4. Lavrado J, Moreira R; Paulo, Alexandra. "Chapter 5. Synthetic strategies towards bioactive indolo(3,2-b)quinolines". In Heterocyclic Targets in Advanced Organic Synthesis, 109-124. Research Signpost, 2011.
    Published
Conference abstract
  1. Cadoni, E et al.; Paulo, Alexandra. "New V-shape modular ligands: synthesis, biophysical, biochemical and in silico studies.". Paper presented in 6th International Meeting on Quadruplex Nucleic Acids, Prague, 2017.
    Published
  2. Paulo, Alexandra; Lavrado, J. et al. "KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indoloquinolines". Paper presented in 5th International Meeting on Quadruplex Nucleic Acids, Bordeaux, 2015.
    Published
  3. Paulo, Alexandra. "Broad SAR Exploration of 3-Piperidin-4-yl-1H-Indole Scaffold: towards a new antimalarial chemotype". Paper presented in EFMC-XXIII International Symposium on Medicinal Chemistry, ChemMedChem 2014; (special issue): 173, Lisbon, 2014.
    Published
  4. Paulo, Alexandra. "G-quadruplex stabilization by novel indolo(3,2-c)quinolines". Paper presented in EFMC – XXIII-International Symposium in Medicinal Chemistry, Lisbon, 2014.
    Published
  5. Paulo, Alexandra; Lavrado, J. et al. "Anticancer profile and G-quadruplex stabilization of indoloquinoline derivatives". Paper presented in 2º Encontro Nacional de Química Terapêutica, Rev. Port. Farmácia 2010, 52 (4): 13, Coimbra, 2010.
    Published
  6. Lavrado, J. et al; Paulo, Alexandra. "Studies towards the mechanism of antimalarial action of cryptolepine C-11 diamino derivatives.". Paper presented in 2º Encontro Nacional de Química Terapêutica, Rev. Port. Farmácia 2010, 52 (4): 33, Coimbra, 2010.
    Published
  7. Santos, SA et al;; Paulo, Alexandra. "Bis-alkylamine quindolone derivatives as new antimalarial leads". Paper presented in 2º Encontro Nacional de Química Terapêutica, Rev. Port. Farmácia 2010, 52 (4): 107, Coimbra, 2010.
    Published
  8. Dias, T, et al; Paulo, Alexandra. "Coreopsis tinctoria useful in glucose-intolerance therapeutics and diabetes prevention ?". Paper presented in 2nd Iberoamerican Congress on Phytotherapy. Revista de Fitoterapia, 9, (supl.1), Lisbon, 2009.
    Published
  9. Lavrado, J.; Paulo, Alexandra; Douglas, K.T. et al. "Antiplasmodial cryptolepine analogues: Interactions with single and double stranded oligonucleotides". Paper presented in 1º Encontro Nacional de Química Terapêutica. Rev. Port. Farmácia 2008, 52 (3): 97, Porto, 2008.
    Published
  10. Dias, T et al.; Paulo, Alexandra. "Coreopsis tinctoria infusions reverse streptozotocin-induced glucose-intolerance in rats.". Paper presented in 1º Encontro Nacional de Química Terapêutica. Rev. Port. Farmácia 2008, 52 (3): 76, Porto, 2008.
    Published
  11. Vítor, R et al.; Paulo, Alexandra. "Caracterização química do decocto das flores de Carqueja e estudo in vitro do seu efeito protector do endotélio". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas. Rev. Port. Farmácia 2003, 52 (supl.): 106, Lisboa, 2003.
    Published
  12. Teixeira G, Vítor, R;; Paulo, Alexandra. "caracteres morfoanatómicos e químicos da Carqueja.". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas. Rev. Port. Farmácia 2003, 52 (supl.): 107, 2003.
    Published
  13. Dias, C et al;; Paulo, Alexandra. "Estudo fitoquímico dos bolbos de Autonoë madeirensis.". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas. Rev. Port. Farmácia 2003, 52 (supl.): 170, 2003.
    Published
  14. Paulo, Alexandra. "The biological activity of Cryptolepis obtusa roots and their contained novel steroidal alkaloids". Paper presented in The 135th British Pharmaceutical Conference. J. Pharmacy and Pharmacology, 1998, 50 (suppl.):223, Eastbourne, 1998.
  15. Paulo, Alexandra; Houghton, PJ; Gomes ET; Duarte A et al. "Studies on the chemistry and in vitro antiplasmodial and antibacterial activity of cryptolepis sanguinolenta leaves.". Paper presented in The 134th British Pharmaceutical Conference. J. Pharmacy and Pharmacology, 1997, 49 (suppl. 4): 115, Scarborough, 1997.
    Published
  16. Paulo, Alexandra; Cabrita J, Pimentel M et al;. "Anti-campylobacter activity of african traditional medicines.". Paper presented in VII International Workshop on Campylobacter, Helicobacter and Related Organisms. Acta Gastro-Enterologica Belga 1993, 56 (supl): 13, Brussels, 1993.
    Published
Conference paper
  1. Paulo, Alexandra; Diniz MA, Silva O, Gomes ET. "Medicinal uses of plants from Guinea-Bissau". Paper presented in The biodiversity of african plants., 1996.
Journal article
  1. Mendes, Eduarda; Bahls, Bárbara; Aljnadi, Israa M.; Paulo, Alexandra. "Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands". Bioorganic & Medicinal Chemistry Letters 72 (2022): 128862. http://dx.doi.org/10.1016/j.bmcl.2022.128862.
    Published • 10.1016/j.bmcl.2022.128862
  2. Mendes, Eduarda; Aljnadi, Israa M.; Bahls, Bárbara; Victor, Bruno L.; Paulo, Alexandra. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals 15 3 (2022): 300. http://dx.doi.org/10.3390/ph15030300.
    Published • 10.3390/ph15030300
  3. Cadoni, Enrico; Magalhães, Pedro R.; Emídio, Rita M.; Mendes, Eduarda; Vítor, Jorge; Carvalho, Josué; Cruz, Carla; Victor, Bruno L.; Paulo, Alexandra. "New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study". Pharmaceuticals 14 7 (2021): 669. http://dx.doi.org/10.3390/ph14070669.
    Open access • Published • 10.3390/ph14070669
  4. Ghosh, Rajat; Vitor, Jorge B.; Mendes, Eduarda; Paulo, Alexandra; Acharya, Pratap Chandra. "Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy". ACS Omega 5 42 (2020): 27332-27343. http://dx.doi.org/10.1021/acsomega.0c03675.
    Open access • Published • 10.1021/acsomega.0c03675
  5. Clemens Zwergel; Rossella Fioravanti; Giulia Stazi; Federica Sarno; Cecilia Battistelli; Annalisa Romanelli; Angela Nebbioso; et al. "Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation". Cancers 12 2 (2020): 447-447. https://doi.org/10.3390/cancers12020447.
    Open access • Published • 10.3390/cancers12020447
  6. Mendes, E.; Cadoni, E.; Carneiro, F.; Afonso, M.B.; Brito, H.; Lavrado, J.; dos Santos, D.J.V.A.; et al. "Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells". ChemMedChem 14 14 (2019): 1325-1328.
    Published • 10.1002/cmdc.201900243
  7. Ana Rita Duarte; Enrico Cadoni; Ana S. Ressurreição; Rui Moreira; Alexandra Paulo. "Design of Modular G-quadruplex Ligands". ChemMedChem 13 (2018): 869-893. https://doi.org/10.1002/cmdc.201700747.
    Published • 10.1002/cmdc.201700747
  8. Mariz, I.F.A.; Pinto, S.; Lavrado, J.; Paulo, A.; Martinho, J.M.G.; Maçôas, E.M.S.. "Cryptolepine and quindoline: Understanding their photophysics". Physical Chemistry Chemical Physics 19 16 (2017): 10255-10263.
    10.1039/c7cp00455a
  9. Francisco, A.P.; Paulo, A.. "Oncogene expression modulation in cancer cell lines by DNA G-quadruplex-interactive small molecules". Current Medicinal Chemistry 24 (2017): 4873-4904.
    10.2174/0929867323666160829145055
  10. Santos, S.A.; Lukens, A.K.; Coelho, L.; Nogueira, F.; Wirth, D.F.; Mazitschek, R.; Moreira, R.; Paulo, A.. "Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype". European Journal of Medicinal Chemistry 102 (2015): 320-333.
    10.1016/j.ejmech.2015.07.047
  11. Lavrado, J.; Ohnmacht, S.A.; Correia, I.; Leitão, C.; Pisco, S.; Gunaratnam, M.; Moreira, R.; et al. "Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex". ChemMedChem 10 5 (2015): 836-849.
    10.1002/cmdc.201500067
  12. Figueiras, M.; Coelho, L.; Wicht, K.J.; Santos, S.A.; Lavrado, J.; Gut, J.; Rosenthal, P.J.; et al. "N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity". Bioorganic and Medicinal Chemistry 23 7 (2015): 1530-1539.
    Published • 10.1016/j.bmc.2015.02.007
  13. Lavrado, J.; Brito, H.; Borralho, P.M.; Ohnmacht, S.A.; Kim, N.-S.; Leitão, C.; Pisco, S.; et al. "KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines". Scientific Reports 5 (2015): 9696.
    Open access • Published • 10.1038/srep09696
  14. Brito, H.; Martins, A.C.; Lavrado, J.; Mendes, E.; Francisco, A.P.; Santos, S.A.; Ohnmacht, S.A.; et al. "Targeting KRAS oncogene in colon cancer cells with 7-carboxylate Indolo[3,2-b] quinoline tri-alkylamine derivatives". PLoS ONE 10 5 (2015): e0126891.
    Open access • Published • 10.1371/journal.pone.0126891
  15. Paulo, A.; Figueiras, M.; MacHado, M.; Charneira, C.; Lavrado, J.; Santos, S.A.; Lopes, D.; et al. "Bis-alkylamine indolo[3,2- B ]quinolines as hemozoin ligands: Implications for antimalarial cytostatic and cytocidal activities". Journal of Medicinal Chemistry 57 8 (2014): 3295-3313.
    Published • 10.1021/jm500075d
  16. Santos, S.A.; Paulo, A.. "Small molecule inhibitors of multidrug resistance gene (MDR1) expression: Preclinical evaluation and mechanisms of action". Current Cancer Drug Targets 13 8 (2013): 814-828.
    Published • 10.2174/15680096113139990082
  17. Lavrado, J.; Borralho, P.M.; Ohnmacht, S.A.; Castro, R.E.; Rodrigues, C.M.P.; Moreira, R.; Dos Santos, D.J.V.A.; Neidle, S.; Paulo, A.. "Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains". ChemMedChem 8 10 (2013): 1648-1661.
    Published • 10.1002/cmdc.201300288
  18. Rocha E Silva, L.F.; Montoia, A.; Amorim, R.C.N.; Melo, M.R.; Henrique, M.C.; Nunomura, S.M.; Costa, M.R.F.; et al. "Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog". Phytomedicine 20 1 (2012): 71-76.
    Published • 10.1016/j.phymed.2012.09.008
  19. Lavrado, J.; MacKey, Z.; Hansell, E.; McKerrow, J.H.; Paulo, A.; Moreira, R.. "Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives". Bioorganic and Medicinal Chemistry Letters 22 19 (2012): 6256-6260.
    Published • 10.1016/j.bmcl.2012.07.104
  20. Lavrado, J.; Paulo, A.; Bichenkova, E.; Douglas, K.T.; Moreira, R.. "1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities". Magnetic Resonance in Chemistry 50 3 (2012): 216-220.
    Published • 10.1002/mrc.2873
  21. Dias, T.; Liu, B.; Jones, P.; Houghton, P.J.; Mota-Filipe, H.; Paulo, A.. "Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells". Journal of Ethnopharmacology 139 2 (2012): 485-492.
    Published • 10.1016/j.jep.2011.11.038
  22. Lavrado, J.; Cabal, G.G.; Prudêncio, M.; Mota, M.M.; Gut, J.; Rosenthal, P.J.; Díaz, C.; et al. "Incorporation of basic side chains into cryptolepine scaffold: Structure-antimalarial activity relationships and mechanistic studies". Journal of Medicinal Chemistry 54 3 (2011): 734-750.
    10.1021/jm101383f
  23. Lavrado, J.; Reszka, A.P.; Moreira, R.; Neidle, S.; Paulo, A.. "C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization". Bioorganic and Medicinal Chemistry Letters 20 23 (2010): 7042-7045.
    Published • 10.1016/j.bmcl.2010.09.110
  24. Dias, T.; Bronze, M.R.; Houghton, P.J.; Mota-Filipe, H.; Paulo, A.. "The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats". Journal of Ethnopharmacology 132 2 (2010): 483-490.
    Published • 10.1016/j.jep.2010.08.048
  25. Lavrado, J.; Gani, K.; Nobre, P.A.; Santos, S.A.; Figueiredo, P.; Lopes, D.; Rosário, V.D.; et al. "Bis-alkylamine quindolone derivatives as new antimalarial leads". Bioorganic and Medicinal Chemistry Letters 20 19 (2010): 5634-5637.
    Published • 10.1016/j.bmcl.2010.08.043
  26. Lavrado, J.; Moreira, R.; Paulo, A.. "Indoloquinolines as scaffolds for drug discovery". Current Medicinal Chemistry 17 22 (2010): 2348-2370.
    Published • 10.2174/092986710791698521
  27. Dias, T.; Mota-Filipe, H.; Liu, B.; Jones, P.; Houghton, P.J.; Paulo, A.. "Recovery of oral glucose tolerance by wistar rats after treatment with Coreopsis tinctoria infusion". Phytotherapy Research 24 5 (2010): 699-705.
    Published • 10.1002/ptr.2998
  28. Dias, T; Mota-Filipe, H; Houghton, PJ; Bronze, MR; Paulo, A. "The flavonoid rich fraction of Coreopsis tinctoria promotes glucose tolerance regain in streptozotocin-induced glucose-intolerant rats". Planta Medica 75 09 (2009): 1009. http://dx.doi.org/10.1055/s-0029-1234724.
    Published • 10.1055/s-0029-1234724
  29. Dias, T; Mota-Filipe, H; Houghton, PJ; Paulo, A. "Antihyperglycaemic effect of Coreopsis tinctoria aqueous extract in streptozotocin-induced glucose-intolerant rats". Planta Medica 74 09 (2008): 954. http://dx.doi.org/10.1055/s-0028-1084059.
    Published • 10.1055/s-0028-1084059
  30. Paulo, A.; Martins, S.; Branco, P.; Dias, T.; Borges, C.; Rodrigues, A.I.; Costa, M.D.C.; Teixeira, A.; Mota-Filipe, H.. "The opposing effects of the flavonoids isoquercitrin and sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats". Phytotherapy Research 22 4 (2008): 539-543.
    Published • 10.1002/ptr.2403
  31. Lavrado, J.; Paulo, A.; Gut, J.; Rosenthal, P.J.; Moreira, R.. "Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity". Bioorganic and Medicinal Chemistry Letters 18 4 (2008): 1378-1381.
    Published • 10.1016/j.bmcl.2008.01.015
  32. Paulo, A.; Mota-Filipe, H.. "Effects of some natural 5-hydroxy-isoflavones on cultured human endothelial cells in presence and absence of hydrogen peroxide". Journal of Pharmacy and Pharmacology 58 1 (2006): 101-105.
    Published • 10.1211/jpp.58.1.0012
  33. Paulo, A.; Dias, C.; Jimeno, M.L.; Borges, C.; Nascimento, J.. "A new ¿7,22 sterol from the bulbs of Autonoë madeirensis". Fitoterapia 76 7-8 (2005): 765-767.
    Published • 10.1016/j.fitote.2005.06.002
  34. Vitor, R.F.; Mota-Filipe, H.; Teixeira, G.; Borges, C.; Rodrigues, A.I.; Teixeira, A.; Paulo, A.. "Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury". Journal of Ethnopharmacology 93 2-3 (2004): 363-370.
    Published • 10.1016/j.jep.2004.04.003
  35. Dias, C.; Paulo, A.; Nascimento, J.; Houghton, P.; Hawkes, J.E.; Conçalves, M.L.. "2-(4'-Aminobenzenamine)-pyrimidine, a New a-Antagonist from Autonoë madeirensis". Planta Medica 69 11 (2003): 1060-1062.
    Published • 10.1055/s-2003-45158
  36. Paulo, A.; Houghton, P.J.. "Chemotaxonomic analysis of the genus Cryptolepis". Biochemical Systematics and Ecology 31 2 (2003): 155-166.
    Published • 10.1016/S0305-1978(02)00075-3
  37. Dias, C.; Dias, M.; Borges, C.; Almoster-Ferreira, M.A.; Paulo, A.; Nascimento, J.. "Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques". Journal of Mass Spectrometry 38 12 (2003): 1240-1244.
    Published • 10.1002/jms.554
  38. Paulo, A.; Gomes, E.T.; Steele, J.; Warhurst, D.C.; Houghton, P.J.. "Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots". Planta Medica 66 1 (2000): 30-34.
    Published • 10.1055/s-2000-11106
  39. Paulo, A.; Jimeno, M.L.; Gomes, E.T.; Houghton, P.J.. "Steroidal alkaloids from Cryptolepis obtusa". Phytochemistry 53 3 (2000): 417-422.
    Published • 10.1016/S0031-9422(99)00568-3
  40. Paulo, A.; Gomes, E.T.; Duarte, A.; Perrett, S.; Houghton, P.J.. "Chemical and antimicrobial studies on Cryptolepis obtusa leaves". Fitoterapia 68 6 (1997): 558-559.
    Published
  41. Paulo, A.; Gomes, E.T.; Houghton, P.J.. "New alkaloids from Cryptolepis sanguinolenta". Journal of Natural Products 58 10 (1995): 1485-1491.
    Published • 10.1021/np50124a002
  42. Paulo, A.; Duarte, A.; Gomes, E.T.. "In vitro antibacterial screening of Cryptolepis sanguinolenta alkaloids". Journal of Ethnopharmacology 44 2 (1994): 127-130.
    Published • 10.1016/0378-8741(94)90079-5
  43. Paulo, A.; Pimentel, M.; Viegas, S.; Pires, I.; Duarte, A.; Cabrita, J.; Gomes, E.T.. "Cryptolepis sanguinolenta activity against diarrhoeal bacteria". Journal of Ethnopharmacology 44 2 (1994): 73-77.
    Published • 10.1016/0378-8741(94)90071-X
Thesis / Dissertation
  1. Paulo, Alexandra. "Chemical and biological studies on african Cryptolepis species". PhD, King's College London, 1998.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06/25 In Silico studies for developing new cancer therapeutics targeting DNA G-quadruplexes. 7th Computationally Driven Drug Discovery Meeting
Italian Chemical Society, Division of Medicinal Chemistry. (Italy)
2020/10/15 Challenges in the design of promoter G4 targeting small molecules (invited webinar) Webinar - Nucleic Acid secondary Structures and Beyond
University of Padova (Italy)
2020/08/28 Targeting quadruplex nucleic acids for cancer therapy. (Invited webinar) International Webinar on Drug Discovery & Drug Development
Tripura University (India)
2020/01 Challenges in the design of oncogene and p53 expression modulators. Keynote. 13th National Meeting of Organic Chemistry and 6th National Meeting of Medicinal Chemistry
Portuguese Society of Chemistry (Aveiro, Portugal)
2019/07 Targeting oncogene expression with small molecules: challenges and achievements. Invited Lecture XIV Annual Symposium of CICS-UBI
Universidade da Beira Interior (Covilhã, Portugal)
2017/07 Targeting oncogene expression with small molecules. Invited Communication. 1st Meeting of Lisbon University Chemistry College
University of Lisbon (Lisbon, Portugal)
2016/07 Targeting KRAS oncogene with G4-interactive small molecules. (Invited Communication) 8th iMed.ULisboa Postgraduate Students Meeting
Faculty of Pharmacy, ULisboa (Lisbon, Portugal)
2014/04 DNA G-quadruplex ligands for cancer therapy. (Invited Communication) ChemULisboa: New challenges in Chemistry in ULisboa
University of Lisbon (Lisbon, Portugal)
2013/06 From Africa to Africa: design of cryptolepine-based new antimalarials. (Invited Communication) Drug Discovery & Therapy World Congress
(Boston, United States)
2010 Investigação em Fitoquímica e Fitoterapia em Portugal. (Invited Lecture) IV Colóquio de Farmácia: Investigação em Portugal.
Escola Superior de Tecnologia da Saúde do Porto
2009 Novel analogues of the antiplasmodial natural indoloquinoline cryptolepine. (Invited Communication) 2º Encontro da Plataforma Ibérica da Malaria.
GSK, Diseases of the Developing World Research Centre, Madrid (Tres Cantos) (Madrid, Spain)
2009 Algumas plantas medicinais de Portugal e seus princípios ativos. (Invited Lecture) IV Simpósio Iberoamericano de Plantas Medicinais.
(Brazil)
2009 From traditional medicines to drug leads: the case of cryptolepine. (Invited communication) Conferência-Debate: Malaria 2009
Fundação Luso-Americana (Lisbon, Portugal)
2009 Fitoquímica em Fitoterapia: porquê e para quê? (Invited Lecture) 15ª Jornadas de Ciências Farmacêuticas: A Diversidade da Farmácia Contemporânea.
Instituto Superior de Ciências da Saúde Egas Moniz, Caparica, (Portugal)
2008 Pesquisa de compostos bioactivos em plantas medicinais: o exemplo da Carqueja ibérica. (Invited lecture) III Simpósio Iberoamericano de Plantas Medicinais
Universidade Estadual de Ponta Grossa (Brazil)
2000 Chemical and biological studies on two african Cryptolepis species. (Invited Lecture) 1ª Jornadas da Sociedade Portuguesa de Ciências Farmacêuticas.
Faculdade de Farmácia da Universidade do Porto (Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/04 - 2024 Development of G4 ADN - Helicase Interaction Inhibitors
Supervisor of Israa Aljnadi
Medicinal Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/01 - 2022/09/30 Computer-assisted design and synthesis of DNA-G4/helicase interaction inhibitors
Supervisor of Bárbara Bruni
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020/12 Síntese de compostos indólicos ativadores da p53
Supervisor of Adriana Margarida Duarte e Silva
Química Medicinal e Biofarmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2018 Development of p53 activators for anticancer therapy
Supervisor of Saiima Bered (Erasmus)
Pharmacy (Degree)
University College London School of Pharmacy, United Kingdom
2016 - 2017 Synthesis of new G-quadruplex ligands
Supervisor of Enrico Cadoni (Erasmus+)
Pharmacy (Master)
Università degli Studi di Roma La Sapienza, Italy
2016 - 2017 Derivados de bis-quinolinas como potenciais ligandos de G-quadruplexos de ADN: síntese e relações estrutura-atividade
Supervisor of Rita Santos
Ciências Farmacêuticas (Scientific initiation)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017 Desenvolvimento de análogos da criptolepina como sondas fluorescentes
Co-supervisor of Miguel Soares
Ciências Farmacêuticas (Scientific initiation)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Complexos de cobre dirigidos a G-quadruplex para teranóstica de cancro
Co-supervisor of Raquel Cristina Barão Correia
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Derivados de quinolinas ou isoquinolinas como potenciais ligandos seletivos de G-quadruplexos de ADN para a terapia do cancro
Co-supervisor of Jessica Gaspar
Ciências Farmacêuticas (Scientific initiation)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016 Medicinal Chemistry Approaches to Malaria Drug Discovery
Supervisor of Sofia Alexandre Santos
Pharmacy (Medicinal Chemistry) (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Targeting KRAS oncogene expression with G-quadruplex ligands
Supervisor of Filipa Andreia Cardoso Carneiro
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Ligandos seletivos de G-quadruplexos de ADN para a terapia do cancro
Supervisor
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Ligandos seletivos de G-quadruplexos de ADN para a terapia do cancro: Triazinas trisubstituídas
Co-supervisor of Mariana Sofia Matos Marques
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011 Síntese e avaliação de derivados bis-alquilamina de quindolonas como protótipos de novos antimaláricos bifuncionais
Supervisor of Marisa Frias Nogueira
Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2011 Phytochemical study of Coreopsis Tinctoria and evaluation of its antidiabetic properties.
Supervisor of Maria Teresa Matos de Figueiredo Ribeiro Dias
Pharmacy (Medicinal Chemistry) (PhD)
Universidade de Lisboa, Portugal
2006 - 2010 Novel C11amino Derivatives of Cryptolepine Synthesis and in Vitro Studies with Dna and Haeme
Co-supervisor of João Paulo Martins Ferreira Lavrado
Pharmacy (Medicinal Chemistry) (PhD)
Universidade de Lisboa, Portugal
2006 - 2006 Phytochemical study and radical scavenger activity of Coreopsis tinctoria polar extracts
Supervisor of Denise Serras Geraldes (Erasmus)
Pharmacy (Degree)
Universiteit Utrecht, Netherlands
1998 - 2003 Caracterização fitoquímica dos bolbos de Autonoë madeirensis. Estudo farmacológico do extracto etanólico e da 2-(4’-aminobenzenamina)-pirimidina
Supervisor of Catarina Soares Braga da Mota Rodrigues Dias
Pharmacy (Phytochemistry and Pharmacognosy) (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2000 - 2001 Caracterização química do extracto aquoso das flores de Carqueja e estudo do seu efeito protector do tecido endotelial
Supervisor of Rute Maria Filipe Vítor.
Química Farmacêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/11/14 A Tale of Furan and Nucleic Acids: The exploration of furan chemistry as a versatile tool for targeting oligonucleotides.
(Thesis) Main arguer
Enrico Cadoni (PhD)
Universiteit Gent, Belgium
2020/12/14 G-quadruplex aptamers for cervical cancer therapy
(Thesis) Arguer
Josué L. O. Carvalho (PhD)
Universidade da Beira Interior, Portugal
2020 Síntese e avaliação de novas moléculas híbridas para o tratamento do melanoma maligno metastático
(Thesis) Arguer
Sofia Gomes Serra (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2019 - 2023 COST Action INC: International Nucleome Consortium (CA18127) Member of Management Committee
2006 - 2009 Rede Iberoamericana de Estudo e Aproveitamento Sustentável da Biodiversidade Regional de Interesse Farmacêutico (RIBIOFAR), funded by Programa Iberoamericano de Ciência e Tecnologia para el Desarrollo (CYTED) Portuguese team leader

Journal scientific committee

Journal title (ISSN) Publisher
2017 - Current Scientific Reports (2045-2322) Springer Nature Publishing Group
2014 - Current Frontiers in Chemistry (2296-2646) Frontiers Media SA
2020/06 - 2021/12 Pharmaceuticals (ISSN 1424-8247) MDPI
2010 - 2014 Organic and Medicinal Chemistry Letters (2191-2858) Springer (Biomed Central Ltd.)

Mentoring / Tutoring

Topic Student name
2011 - 2016 Computer-assisted design, synthesis and evaluation of novel G-quadruplex ligands as selective anticancer agents João Paulo Martins Ferreira Lavrado (Pos-Doc)