Identification
Personal identification
- Full name
- Andreia Alexandra Neves de Carvalho
- Date of birth
- 1984/03/27
- Gender
- Female
Citation names
- Neves-Carvalho, Andreia
Author identifiers
- Ciência ID
- 281E-C57D-5DA3
- ORCID iD
- 0000-0002-5710-0040
Email addresses
- andreiacarvalho@med.uminho.pt (Professional)
- andreia.an.carvalho@gmail.com (Personal)
Telephones
- Telephone
-
- 253605835 Ext.: 604835 (Professional)
Addresses
- Instituto de Ciências da Vida e da Saúde (ICVS). Escola de Ciências da Saúde, Campus de Gualtar, Universidade do Minho, 4710, Braga, Braga, Portugal (Professional)
Websites
- http://www.icvs.uminho.pt (Professional)
- http://www.icvs.uminho.pt/about-icvs/people/andreiacarvalho (Professional)
Knowledge fields
- Social Sciences - Media and Communications
- Exact Sciences - Mathematics - Statistics and Probability
- Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
- Exact Sciences - Mathematics - Statistics and Probability
- Exact Sciences - Computer and Information Sciences - Bioinformatics
- Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
- Natural sciences - Biological Sciences - Biochemical Research Methods
- Natural sciences - Biological Sciences - Cell Biology
- Natural sciences - Biological Sciences - Cell Biology
- Social Sciences - Media and Communications
- Medical and Health Sciences - Basic Medicine
- Medical and Health Sciences - Basic Medicine
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Spanish; Castilian | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) | Beginner (A1) |
Portuguese (Mother tongue) |
Education
Degree | Classification | |
---|---|---|
2020
Ongoing
|
Postdoctoral Fellow (Pós-doutoramento)
Major in Neurosciences
Universidade do Minho, Portugal
|
n/a |
2009 - 2014
Concluded
|
Health Sciences (Doutoramento)
Major in Health Sciences
Universidade do Minho Escola de Medicina, Portugal
Vrije University Amsterdam Onderzoeksgroep Organische Chemie, Netherlands "When gaining is losing: insights into the function of ataxin-3 and its perturbation in the context of Machado-Joseph disease" (THESIS/DISSERTATION)
|
Aprovado por unanimidade |
2009
Concluded
|
Molecular Genetics MSc (Mestrado)
Major in Molecular Genetics MSc
Universidade do Minho Escola de Ciências, Portugal
"Increased thermotolerance in the absence of ataxin-3 in C. elegans" (THESIS/DISSERTATION)
|
19 |
2007
Concluded
|
Aplied Biology (Licenciatura)
Major in Aplied Biology
Universidade do Minho Escola de Ciências, Portugal
"Estudo de parceiros moleculares da proteina de C.elegans envolvida na doença de Machado-Joseph, ATX-3" (THESIS/DISSERTATION)
|
15 |
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2014/12/01 - Current | Postdoc (Research) | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
Others
Category Host institution |
Employer | |
---|---|---|
2017/09/01 - Current | Posdoctoral fellowship: "Study of Cerebellar (Dys)function in Spinocerebellar Ataxia Type 3" | Fundação para a Ciência e a Tecnologia, Portugal |
2016/06/01 - 2017/12/31 | Posdoctoral grant: “Study of Tau splicing in the context of Machado-Joseph disease” | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2017/02/15 - 2017/08/31 | Posdoctoral grant:" Testing the therapeutic potential of Mesenchymal Cells and their secretive in an animal model of spinocerebellar ataxia type 3" | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2014/03/01 - 2015/05/28 | Research grant: “Estudo da função da ubiquitina hydrolase ataxina-3 em neurónios” | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2009/09/01 - 2014/12/01 | PhD student | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2008/01/01 - 2013/12/31 | Team member of a scientific project: PTDC/SAU-GMG/101572/2008 – “Ataxin-3: gain and loss of Machado-Joseph Disease” | Fundação para a Ciência e a Tecnologia, Portugal |
2007/09/01 - 2008/07/15 | Especialidade em Genética Molecular | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
2006/12/01 - 2007/12/31 | Estágio | Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal |
Projects
Grant
Designation | Funders | |
---|---|---|
2016/01/02 - 2016/12/31 | Testing the Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in an Animal Model of Spinocerebellar Ataxia
Type 3
NAF_PI_2016(ID1087)
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
National Ataxia Foundation
Concluded
|
2013/05 - 2015/09 | Proteostasis as a link between longevity pathways and neurodegenerative diseases
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
|
2010/04 - 2013/09 | Ataxin-3: gain and loss of function in Machado-Joseph disease
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2007 - 2012 | Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostico genético
Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostic genético
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Concluded
|
Contract
Designation | Funders | |
---|---|---|
2018 - 2021 | Combining Mesenchymal Stem Cells (MSCs) Secretome and Pharmacotherapies for the treatment of Parkinson's Disease
POCI-01-0145-FEDER-029751
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2020 | Nuclear Ataxin-3 Protein-protein Interactions as Therapeutic Targets in Machado-Joseph Disease
GFP-NAPPIT-MJD-04/2019
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2007 - 2012 | Atraso Mental Idiopático: avaliação de uma esratégia de microarray CGH para diagnostic genético
PIC//IC/83026/2007
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Conference poster |
|
Journal article |
|
Thesis / Dissertation |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2019 | Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors: implication for disease | RNA Meeting: ptRNA2019
(Porto, Portugal)
|
2019 | Study of Cerebellar circuits (Dys)function in Spinocerebellar Ataxia Type 3 | Molecular Neuroscience: From genes to circuits in health and disease
EMBO (Bangalore, India)
|
2019 | Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors | International Ataxia Research Conference
(United States)
|
2019 | Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease | IV Symposium of the Portuguese Glial Network; |
2019 | Microglial and astrocytic pathology in a mouse model of Machado-Joseph disease | International Ataxia Research Conference |
2018 | Testing the Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in an Animal Model of Machado-Joseph disease | Portuguese Society of Movement disorders
(Curia, Portugal)
|
2018 | Testing peripheral BDNF gene delivery using neuron-targeted nanoparticles as a strategy to reduce skeletal muscle atrophy and motor neuronopathy in a mouse model of SCA3 | Portuguese Society of Movement Disorders |
2017 | Study of the function of ATXN3, a DUB enzyme involved in Machado-Joseph disease | Bioinformatics postgraduation course
Universidade do Minho (Braga, Portugal)
|
2017 | Transfection methods: overview | Molecular and cellular analysis posgraduation course
Universidade do Minho (Braga, Portugal)
|
2017 | Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease | V Jornadas de Química e Bioquímica
Universidade da Beira Interior (Portugal)
|
2017 | Loss of function of ATXN3 alters the ubiquitome of neuronal cells, negatively impacting on the splicing process | São Paulo School of Advanced Science on Mass Spectrometry -based Proteomics (SPSAS-MS)
Universidade de Campinas - UNICAMP (Campinas, Brazil)
|
2017 | ATXN3 modulates mRNA splicing of Tau through ubiquitylation of splicing factors | Portuguese Society for Neuroscience (SPN) 2017
Portuguese Society for Neuroscience (SPN) (Braga, Portugal)
|
2017 | Regulation of neuronal mRNA splicing by ATXN3 is disturbed in SCA3/MJD | International Ataxic Research Conference (IARC) - 2017
International Ataxic Research Conference (IARC) (Pisa, Italy)
|
2017 | Neuroprotective effects of creatine-supplemented diet in the CMVMJD135 mouse model of Machado-Joseph disease | Portuguese Society of Movement disorders - 2017
Portuguese Society of Movement disorders (Portugal)
|
2016 | TUDCA reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph disease | Ataxia Investigators Meeting (AIM) - 2016
Ataxia Investigators Meeting (AIM) (Florida, United States)
|
2015 | Citalopram treatment ameliorates motor impairment and suppresses ataxin-3 aggregation in a Machado-Joseph disease mouse model | Ataxia Research Conference - 2015
Ataxia Research Conference (Windsor, United Kingdom)
|
2014 | Study of the function of ATXN3, a DUB enzyme involved in Machado-Joseph disease | Bioinformatics postgraduation course
Universidade do Minho (Braga, Portugal)
|
2014 | When gaining is loosing: insights into the function of ataxia-3 and its perturbation in the context of Machado-Joseph Disease | XVIII Congress of the Portuguese Biochemical Society - 2014
XVIII Congress of the Portuguese Biochemical Society (Coimbra, Portugal)
|
2014 | Mesenchymal stem cells secretome: a new therapeutic tool for Central Nervous System repair? | 6th Meeting FIRST
(Milão, Italy)
|
2013 | Tauroursodeoxycholic acid reduces neuroinflammation and improves motor symptoms in a transgenic mouse model of Machado-Joseph Disease | Portuguese Society of Movement Disorders
(Portugal)
|
2013 | Loss of function of the DUB Ataxin-3 affects differentiation, proliferation and cytoskeletal organization of neuronal cells through the modulation of ITGA5 levels | 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference
(Filadélfia, United States)
|
2012 | 17-DMAG and Valproic Acid improve the phenotype of a new transgenic mouse model of Machado-Joseph Disease | Ataxia Research Conference (ARC)
(Londres, United Kingdom)
|
2009 | Ataxin-3, UBXN-5 and CDC-48: a new trimolecular complex in C. elegans | V International Workshop on Machado-Joseph Disease
(S. Miguel, Portugal)
|
2009 | Increased thermotolerace and hormesis in the absence of ataxin-3 in C. elegans | V International Workshop on Machado-Joseph Disease
(S. Miguel, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2020 - Current | "Ataxin-3 as a biomarker in gliomas"
Supervisor
|
Universidade do Minho, Portugal
|
2020 - 2021 | "Sex differences in Citalopram effect in a Transgenic mouse model of spinocerebellar ataxia type 3"
Supervisor
|
|
2020 - 2021 | "A comprehensive characterisation of the cerebellar (dye)function in spinocerebellar ataxia type 3"
Supervisor
|
Universidade do Minho, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2019 - 2019 | XII Annual Scientific Neurosciences Retreat (2019 - 2019) | Universidade do Minho, Portugal |
2018 - 2018 | XII Annual Scientific Neurosciences Retreat (2018 - 2018)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
2018 - 2018 | I Workshop on the Cerebellum (2018 - 2018)
Workshop (President of the Organising Committee)
|
Universidade do Minho, Portugal |
2017 - 2017 | XI Annual Scientific Neurosciences Retreat (2017 - 2017)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
2005 - 2005 | VI Applied Biology students Meeting (2005 - 2005)
Meeting (Member of the Organising Committee)
|
Universidade do Minho, Portugal |
Event participation
Activity description Type of event |
Event name Institution / Organization |
|
---|---|---|
2019 - Current | Poster presentation
Congress
|
RNA Meeting: ptRNA2019
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2017 - Current | Oral communication
Workshop
|
São Paulo School of Advanced Science on Mass Spectrometry -based Proteomics (SPSAS-MS)
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
|
2018 - 2018 | Poster presentation
Congress
|
7th Ataxia Investigators Meeting
National Ataxia Foundation, United States
|
2018 - 2018 | Oral communication
Congress
|
Portuguese Society of Movement disorders |
2017 - 2017 | Oral communication
Congress
|
International Ataxia Research Conference (IARC) |
2017 - 2017 | Oral communication
Congress
|
XV Portuguese Society for Neuroscience (SPN) |
2015 - 2015 | Poster presentation
Congress
|
XXII Annual Meeting of Portuguese Society for Neurosciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2014 - 2014 | Oral communication
Congress
|
5th Ataxia Investigators Meeting
National Ataxia Foundation, United States
|
2014 - 2014 | Oral communication
Congress
|
XVIII Congress of the Portuguese Biochemical Society |
2013 - 2013 | Oral communication
Congress
|
5th Annual Ubiquitin Drug Discovery & Diagnostics Conference
Ubiquitin Conferences, United States
|
2013 - 2013 | Poster presentation
Congress
|
XIII Portuguese Society for Neurosciences (SPN)
Universidade de Coimbra, Portugal
|
2013 - 2013 | Poster presentation
Congress
|
XXXVIII Portuguese Meeting of Genetics
Universidade do Porto, Portugal
|
2012 - 2012 | Poster communication
Congress
|
6th National Meeting on Cell Signaling (SINAL)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
2010 - 2010 | Participation as a student in the EMBO practical course: Ubiquitin and SUMO
Workshop
|
EMBO practical course: Ubiquitin and SUMO
Cancer Research UK, United Kingdom
|
2010 - 2010 | Poster presentation
Congress
|
Proteomics of Protein Degradation & Ubiquitin Pathways (PPDUP)
International Forum of Proteomics, Canada
|
2009 - 2009 | Oral communication
Workshop
|
V Workshop on Machado-Joseph Disease
Universidade dos Açores Departamento de Biologia, Portugal
|
2004 - 2004 | Participation in Applied Biology students Meeting
Meeting
|
VI Meeting of Applied Biology
Universidade do Minho, Portugal
|
2003 - 2003 | Participation in the Applied Biology students Meeting
Meeting
|
V Meeting of Applied Biology
Universidade do Minho, Portugal
|
2002 - 2002 | Participation in the Applied Biology students Meeting
Meeting
|
IV Meeting of Applied Biology
Universidade do Minho, Portugal
|
2000 - 2000 | Workshop within the program "Ciência viva"
Workshop
|
Química Aplicada - Iniciação à Investigação
Ministério da Ciência e da Tecnologia, Portugal
|
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2017 - Current | Laboratory Animal Sciences Advanced course at ICVS - Practical classes | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
2017 - Current | Molecular and Cellular Analysis Course | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
2017 - Current | Bioinformatics course | (Curso de doutoramento (conclusão de unidades curriculares)) | Universidade do Minho, Portugal |
Evaluation committee
Activity description Role |
Institution / Organization | Funding entity | |
---|---|---|---|
2019 - Current | Evaluation of students performance on the Laboratory Animal Sciences course
Evaluator
|
Universidade do Minho, Portugal |
Interview (tv / radio show)
Program | Topic | |
---|---|---|
2017 - 2017 | Filmed at the International Ataxia Research Conference 2017 | Regulation of neuronal mRNA splicing by ATXN3 is disturbed in SCA3/MJD |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2019 - Current | Project development | Liliana Costa |
2019 - Current | Project development | Ana Cristina Fernandes |
2019 - Current | Ana Catarina Ferreira | |
2019 - Current | Ana Cristina Fernandes | |
2019 - Current | Liliana Costa | |
2012 - Current | Fátima Lopes | |
2012 - Current | Joana Silva | |
2019 - 2020 | Master in Health Science: Laboratory rotation | Ana Margarida Sousa |
2019 - 2020 | Master in Health Science: Laboratory rotation | Beatriz Ferreira |
2018 - 2019 | Trainnee student: Bachelor in Biochemistry | Catarina Ferreira |
2013 - 2014 | Mestrado | Revina Marslin |
2013 - 2014 | "Stable silencing of Ataxin-3 leads to abnormal differentiation in neuronal cells” | Ana Freitas |
2013 - 2013 | Master in Health Science: Laboratory rotation | Revina Mary Ann Marslin |
2013 - 2013 | Master in Health Science | Ana Freitas |
2013 - 2013 | PhD in Health Sciences: Laboratory rotation | Joana Margarida Mota Silva |
2013 - 2013 | PhD in Health Sciences: Laboratory Rotation | Fátima Daniela Lopes |
Distinctions
Award
2021 | Best work at XIII ENEBIOQ Workshop
Universidade of Trás-os-Montes e Alto Douro, Portugal
|
2019 | Best poster award at the VIII National RNA Meeting: ptRNA 2019: “Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors”, Porto (Portugal) |
2019 | Traveling award for EMBO workshop: from genes to disease (India) |
2019 | Travel grant – participation in the EMBO workshop: from genes to disease |
2019 | 3. Best poster presentation at the VII National RNA Meeting: ptRNA2019 |
2018 | National Ataxia Foundation (NAF) award for the AIM Meeting at Philadelphia (USA)
National Ataxia Foundation, United States
|
2018 | Traveling award for EMBO workshop: from genes to disease (India) |
2018 | 1. Travel grant – participation in the 7th Ataxia Investigators Meeting |
2017 | Sociedade Portuguesa de Doenças do movimento (Portugal) |
2016 | Traveling award for Ataxia UK (Italy)
Ataxia UK, United Kingdom
|
2014 | National Ataxia Foundation (NAF) award for the AIM Meeting at Las Vegas (USA)
National Ataxia Foundation, United States
|
2013 | Best poster presentation – Prize Prof Luís Archer: “17-DMAG induces autophagy and delays disease progression in a mouse model
of Machado-Joseph Disease”
Prize Prof Luís Archer, Portugal
|
2013 | Traveling award for the Ubiquitin Discovery & Diagnostics Conference, Philadelphia (USA) |
2013 | Best Abstract award at the Ubiquitin Discovery & Diagnostics Conference: “Loss of function of the DUB Ataxin-3 affects differentiation, proliferation and cytoskeletal organization of neuronal cell through the modulation of ITGA5 levels”, Philadelphia (USA |
2010 | VXII Rafael Hervada award for Biomedical Research: “Genetic and pharmacological modulation of the IIs and HSF-1 pathways rescues
neuronal proteotoxicity in a C. elegans model of Machado-Joseph disease”,
VXII Rafael Hervada award for Biomedical Research, Spain
|
2009 | Best oral communication at the V International workshop on Machado-Joseph Disease: “Ataxin-3, UBXN-5 and CDC-48: a new trimolecular
complex in C. elegans”,
V International workshop on Machado-Joseph Disease, Portugal
|
2008 | Traveling Award for EMBO Practical course |