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Hugo Vicente Miranda is a Principal Investigator and Affiliated Assistant Professor at NOVA Medical School, leading the Dysmetabolism in Brain Diseases (DysBrainD) Laboratory. His research explores the intersection between metabolic dysfunction and neurodegeneration, with a particular focus on Parkinson’s disease (PD) and type 2 diabetes (T2D). His work has been instrumental in identifying glycation as a pathological trigger of PD, revealing how metabolic alterations contribute to neurodegeneration. During his PhD and postdoctoral training at the lab of Prof. Tiago Outeiro, a recognized leader in PD research, he uncovered the role of Sirtuin 2 in neurodegeneration, developed an enrichment method for a-synuclein in biosamples, and identified post-translational modifications with biomarker potential. Since establishing his independent lab in 2018, he has secured multiple competitive grants, including funding from the Michael J. Fox Foundation, and expanded his research into novel therapeutic strategies targeting metabolic dysfunction, particularly through insulin-degrading enzyme (IDE) modulation and carotid body (CB) silencing. His group has developed automated behavioral analysis pipelines and pioneered studies demonstrating how glycation drives a-synuclein pathology, published in high-impact journals such as Brain and npj Parkinson’s Disease. Vicente Miranda has received multiple research awards, including three prizes from the Portuguese Society for Diabetes and the prestigious Great Prize from the same society in 2021. He is an elected member of NOVA Medical School’s General Council, a scientific committee member of the Portuguese Society for Diabetes, and co-coordinator of its Translational Research Group. Internationally, he has been invited to present at key conferences, including the International Diabetes Federation Congress (IDF 2023) and the European Society for Clinical Investigation (ESCI 2023), and has a selected talk at the upcoming Synuclein Meeting 2025. With 30 publications in high-impact journals, over 2,500 citations, and an h-index of 20 (SCOPUS), he is an active contributor to the scientific community, serving as a reviewer for major journals and funding agencies such as Foundation Recherche Alzheimer and EMSTAR (Serbia). His research vision is to bridge mechanistic discoveries with translational applications, advancing innovative therapeutic strategies that address neurodegeneration through metabolic modulation.
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Identification

Personal identification

Full name
Hugo Miguel Vicente Miranda
Date of birth
1982/12/31
Gender
Male

Citation names

  • Vicente Miranda, Hugo

Author identifiers

Ciência ID
2719-3B78-B060
ORCID iD
0000-0001-8065-9259
Google Scholar ID
26igPEoAAAAJ
Researcher Id
I-3525-2013
Scopus Author Id
57193826021

Email addresses

  • hmvmiranda@nms.unl.pt (Professional)

Telephones

Telephone
  • (+351) 218803127 (Professional)

Addresses

  • NOVA Medical School / Faculdade de Ciências Médicas, Universidade Nova de Lisboa. Rua Câmara Pestana nº 6 | Edifício CEDOC II, 1150-082, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023/03 - 2023/03
Concluded
 Curso Pós-Graduado em Experimentação Animal Prático (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2023/02
Concluded
 Content Theory Course in Laboratory Animal Scienc (Outros)
Congento Consortium for Genetically Tractable Organisms, Portugal
2023/02
Concluded
 Upgrade to function B (Outros)
Congento Consortium for Genetically Tractable Organisms, Portugal
2016/09/01 - 2019/01/31
Concluded
 Neurosciences - Targeting the glycation defenses as a protective strategy for Parkinson’s disease (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018 - 2018
Concluded
 Grant Writing Intensive - Magdalena Bak-Maier (Outros)
Major in Grant Writing
Universidade Nova de Lisboa, Portugal

Make Time Count Ltd, United Kingdom
2017 - 2017
Concluded
 Supervision skills development course (Outros)
Major in Supervisão
Universidade Nova de Lisboa, Portugal
2014/01/01 - 2016/08/31
Concluded
 Neurosciences - Part 2: Modulation of alpha-synuclein aggregation and toxicity: protective strategies for Parkinson’s disease (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal
2014 - 2014
Concluded
 Science Communication workshop - Malcolm Love (Outros)
Major in Science Communication
Blackwell's University of the West of England, United Kingdom
2013/02 - 2013/12
Concluded
 Identification of factors that influence a-synuclein oligomerization in cell culture and in vivo (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal
2010/02/01 - 2013/01/31
Concluded
 Neurosciences - Part 1: Modulation of alpha-synuclein aggregation and toxicity: protective strategies for Parkinson’s disease (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal
2010/02 - 2013/01
Concluded
 Neurosciences: Modulation of alpha-synuclein aggregation and toxicity: protective strategies for Parkinson’s disease (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal
2013 - 2013
Concluded
 Grant Writing Workshop - Judith A. Swan (Outros)
Major in Grant Writing
Princeton University, United States

Instituto de Medicina Molecular, Portugal
2010/01/20
Concluded
 Biochemistry (Doutoramento)
Major in Specialty: Biochemical Regulation
Universidade de Lisboa, Portugal
"Protein Glycation and Methylglyoxal Metabolism in Parkinson´s Disease" (THESIS/DISSERTATION)
 summa cum laude
2010 - 2010
Concluded
 Quantitative Light Microscopy in Living Cells by Harvard Medical School Portugal Program (Outros)
Major in Microscopy
Harvard Medical School, United States

Instituto de Medicina Molecular, Portugal
2008 - 2008
Concluded
 Advanced training in FTMS-ICR (Outros)
Major in Mass Spectrometry
Bruker Daltonik GmbH, Germany

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2005/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Methylglyoxal metabolism and glycation in Saccharomyces cerevisiae Metabolismo do metilglioxal e glicação em Saccharomyces cerevisiae" (THESIS/DISSERTATION)
 17
2005 - 2005
Concluded
 Identification of proteins using mass spectrometry data – practical course (Outros)
Major in Mass spectrometry
Thermo Fisher Scientific Inc Darmstadt, Germany

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Positions / Appointments

Category
Host institution 		Employer
2023/01 - Current Vice-Coordinator of Cardiovascular, Renal and Metabolism Research Area Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/08 - Current Scientific Advisor Dart-Diagnostics, Portugal
2017 - Current Review Editor - Area of Neurodegeneration Frontiers - Academic Journals and Research Community, Switzerland
Frontiers - Academic Journals and Research Community, Switzerland
2020/12 - 2026/12 FACULTY COUNCIL - Elected member Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Others

Category
Host institution 		Employer
2021 - Current Review Editor - Metabolic Physiology Frontiers - Academic Journals and Research Community, Switzerland
Frontiers - Academic Journals and Research Community, Switzerland
2018/09/01 - Current Principal Investigator - Group Leader Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021 - 2024 Sustainability Council Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/01/01 - 2019/01/31 Post-doctoral researcher (funded by FCT) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2014/01/01 - 2019/01/31 Post-doctoral Researcher (funded by FCT) Instituto de Medicina Molecular, Portugal
2013/02/01 - 2013/12/31 Post-doctoral Researcher (Funded by Seventh Framework Programme (FP7) – Medelian Forms of Parkinson’s Disease Instituto de Medicina Molecular, Portugal
2010/02/01 - 2013/01/31 Post-doc researcher (funded by FCT) Instituto de Medicina Molecular, Portugal
2005/01/01 - 2010/01/20 PhD Researcher (funded by FCT) Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
Projects

Grant

Designation Funders
2022 - Current Role of a-synuclein in synucleinopathy
Marohn Stiftung
Researcher
Universitätsklinikum Erlangen, Germany
 IZKF
Ongoing
2019/09/16 - 2024/02/29 Unveiling insulin degrading enzyme as a therapeutic target for Parkinson’s disease (Supervisor of PhD Grant)
SFRH/BD/144743/2019
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/03/01 - 2022/02/28 Underlying role of glycation in the pathogenesis of Parkinson's disease (Supervisor of PhD Grant)
PD/BD/136863/2018
Supervisor
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2021 EMBO short term fellowship - Potential of anti-diabetics to ameliorate aSyn pathology - EUR 9.090,00
STF 8707
Supervisor
University of Leicester, United Kingdom

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Ongoing

Contract

Designation Funders
2023/09/01 - Current Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

GREEN-IT, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - Current IDE Biomarker Potential - EUR 5.000,00
SPD - GIFT 2021
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Sociedade Portuguesa de Diabetologia
Ongoing
2023/04 - 2027/03 Evaluating an Insulin-degrading Enzyme as a Novel Therapeutic Target for Parkinson's Disease - EUR 225.000,00 and EUR 200.000,00 of possible extension
MJFF-021400
Principal investigator
iNOVA4Health, Portugal
 Michael J Fox Foundation for Parkinson's Research
Ongoing
2022/11 - 2024/12 In the Crossroad between metabolic and neurodegenerative diseases - Requested EUR 21.500,00 - Already funded EUR 6.000,00
N/A
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 iNOVA4Health
Ongoing
2023/06 - 2024/05 Modulation of carotid body activity as a therapeutic strategy in the prevention of cognitive decline [EUR 5.000,00]
Bolsa José Luís Medina
Co-Principal Investigator (Co-PI)
iNOVA4Health, Portugal
 Sociedade Portuguesa de Diabetologia
Ongoing
2021 - 2023 Preventing the development of Parkinson's disease in type-2 diabetes patients - EUR 20.000,00
BigPrize 2021
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Sociedade Portuguesa de Diabetologia
Ongoing
2018/01 - 2020/12 Sugar stress in the brain: the missing link between aging, diabetes and Parkinson's disease. [EUR 70.000,00] PI/Coordinator
Multi/04462
Principal investigator
iNOVA4Health, Portugal
 iNOVA4Health
Concluded
2016/06/01 - 2020/02/29 Targeting the glycation defenses as a protective strategy for Parkinson's Disease [EUR 199.961,00] PI
PTDC/NEU-OSD/5644/2014
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/03/01 - 2019/12/31 Sugar stress in the brain [EUR 5000,00] PI
SPD2018 Charneco da Costa
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Sociedade Portuguesa de Diabetologia
Ongoing
2016/05/01 - 2019/10/31 Alzheimer3D: Trifunctional Conjugates for the Selective Drug Delivery in Alzheimer's Disease [EUR 198.364,00]
PTDC/QEQ-MED/5512/2014
Researcher
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/05/01 - 2019/10/31 Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer
PTDC/QEQ-MED/5512/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Medical School, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/09/01 - 2019/01/31 Targeting the glycation defenses as a protective strategy for Parkinson's disease. [EUR 118.000,00] Post-Doc Awardee
SFRH/BPD/109347/2015
Post-doc Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2010/02 - 2016/12 Modulation of alpha-synuclein aggregation and toxicity: protective strategies for Parkinson's disease. [EUR 115.000,00] - Post-doc position Awardee
SFRH / BPD / 64701 / 2009
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Foundation for Science and Tecnology
Concluded
2011 - 2015 Molecular determinants of microglial activation and neuronal dysfunction in in vivo models of Parkinson's disease. [EUR 115.664,00]
PTDC/SAU-ORG/114083/2009
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2014/05/31 Alpha-synuclein as a blood biomarker for Parkinson's disease
info:eu-repo/grantAgreement/FCT/3599-PPCDT/126579/PT
Supervisor
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2014 Alpha-synuclein as a blood biomarker for Parkinson's Disease [EUR 50.000,00] PI
EXPL/NEU-OSD/0606/2012
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2013 Identification of factors that influence alpha-synuclein oligomerization in cell culture and in vivo. [EUR 21.500,00] - Researcher
MEFOPA
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2009 - 2013 Neurasync. Seventh Framework Programme
FP7-PEOPLE-ITN-2008
Researcher
Instituto de Medicina Molecular, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2011/01/01 - 2012/12/31 Strategic Project - UI 612 - 2011-2012
PEst-OE/QUI/UI0612/2011
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2012 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation. [EUR 197.596,00] - Researcher
info:eu-repo/grantAgreement/FCT/3599-PPCDT/102049/PT
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/06/30 Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes.
PTDC/QUI/73430/2006
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/01 - 2010/01 Protein Glycation and Methylglyoxal Metabolism in Parkinson's Disease. [EUR 55.000,00] - PhD position Awardee
SFRH/BD/23035/ 2005
PhD Student Fellow
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
 Foundation for Science and Tecnology

Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2010 Toward an understanding of protein glycation in Parkinson¿s disease. [EUR 76.200,00] - Researcher
PTDC/QUI/73430/2006
Researcher
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2012/09/01 - 2013/10 Modulation of a-synuclein aggregation and toxicity
MSc Thesis
Supervisor
Concluded
Outputs

Publications

Book
  1. Tenreiro, Sandra; Paulo Pereira; Vieira, Otília V; Guimas Almeida, Claudia; Vicente Miranda, Hugo; Helena L.A. Vieira; Miguel C.. From Life Molecules to Global Health. Lisbon, Portugal: NOVA University of Lisbon. 2021.
    Published
Book chapter
  1. Hugo Vicente Miranda; Paula Moreira; Catarina Oliveira. Corresponding author: Hugo Vicente Miranda. "Secrets of Insulin: From Diabetes to Neurodegenerative Diseases - Corresponding Author". In 100 years of Insulin. Portugal: Sociedade Portuguesa Diabetologia, 2023.
    In press
  2. Capucho, Adriana M.; Chegão, Ana; Martins, Fátima O.; Melo, Bernardete F.; Madeira, Natália; Sacramento, Joana F.; Fonseca, Rosalina; Vicente Miranda, Hugo; Conde, Silvia V. Corresponding author: Vicente Miranda, Hugo. "Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changing Insulin Signaling in the Hippocampus and Prefrontal Cortex - CORRESPONDING AUTHOR". In Arterial Chemoreceptors, edited by Conde, Silvia V. Springer - Advances in Experimental Medicine and Biology, 2023.
    In press
  3. Tenreiro, Sandra; Paulo Pereira; Vieira, Otília V; Guimas Almeida, Claudia; Vicente Miranda, Hugo; Helena Vieira; Miguel C Seabra. "Age-related diseases: common mechanisms and therapeutic approaches". In "Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata. Principia, 2021.
    Published
  4. Susana Gonçalves* Co-first; Hugo Vicente Miranda* Co-first; Tiago F. Outeiro. "Novel Molecular Therapeutics in Parkinson's Disease". In Molecular and Cellular Therapeutics, edited by David Whitehouse; Ralph Rapley, 245-265. Wiley-Blackwell, 2012.
    10.1002/9781119967309.ch11
  5. Quintas, Alexandre; Oliveira, L. M. A.; Vicente Miranda, Hugo. "O sistema piruvato desidrogenase". In Bioquímica - organização molecular da vida, edited by Manuel Júdice Halpern; Ana Ponces Freire; Alexandre Quintas. Portugal: LIDEL edições técnicas Lda, 2008.
    Published
Conference abstract
  1. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Role of astrocytic signaling upon synaptic plasticity on AD-like conditions.". Paper presented in Fourteenth Young European Scientist Meeting, Porto, 2019.
    Published
Conference paper
  1. Abecasis, JPR; Ferreira, AEN; Vicente Miranda, Hugo; Gomes, Ricardo Anjos; Sousa Silva, Marta; Cordeiro, Carlos; Ponces-Freire, Ana. "Parameter estimation in multi-enzyme systems using evolutionary algorithms". Paper presented in BKDB2005 – Bioinformatics: Knowledge Discovery in Biology, 2005.
    Published • 10.13140/RG.2.1.1468.8802
Conference poster
  1. Sousa, Luís; Guarda, M; Marçal, AR; Chegão, A; Machado de Oliveira, R; Macedo, MP; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Insulin-degrading enzyme plays a neuroprotective role in an in vitro model of synucleinopathies". Paper presented in Alzheimer's disease / Parkinson's disease (AD/PD) Conference 2024, 2024.
  2. Sousa, Luís; Luzio, B; Chôcho, S; Guarda, M; Almeida, I; Machado de Oliveira, R; Macedo, MP; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Unveiling new links between type-2 diabetes and neurodegenerative diseases: IDE dysfunction as a promoter of cognitive and motor impairments". Paper presented in Alzheimer's disease / Parkinson's disease (AD/PD) Conference 2024, 2024.
  3. Sousa. Luis; de Oliveira RM; Guarda, M; Capucho, A; Chegão, A; Sousa-Lima, I; Macedo, MP; Vicente Miranda, Hugo. Corresponding author: Sousa. Luis. "Unveiling the insulin degrading enzyme as a novel therapeutic target for Parkinson's disease". Paper presented in 14th European Nutrition Conference FENS 2023, 2023.
  4. Sousa, Luis; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Unveiling Insulin-degrading enzyme as a new therapeutic target for Parkinson's disease". Paper presented in FENS Regional Meeting 2023, 2023.
  5. Capucho, AM; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Impact of carotid sinus nerve resection on cognitive function and synaptic plasticity in an animal model of dysmetabolism". Paper presented in FENS Regional Meeting 2023, 2023.
  6. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Glycation modulates glutamatergic signalling and exacerbates Parkinson's disease-like phenotypes". Paper presented in FENS Regional Meeting 2023, 2023.
  7. Capucho, Adriana M.; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Carotid body modulation prevents cognitive deficits and regulates levels of neurodegenerative markers in dysmetabolic rats¿". Paper presented in Warsaw, Poland - 15th International Symposium "Molecular basis of pathology and therapy in neurological disorders", 2022.
  8. Capucho, Adriana M.; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "Carotid body modulation prevents cognitive dysfunction and neurodegenerative processes in prediabetic rats". Paper presented in Europhysiology 2022 - Copenhagen, 2022.
  9. Vicente Miranda, Hugo. "Glycation Modulates Glutamatergic Signaling and Exacerbates Parkinson’s Disease-Like Phenotypes". Paper presented in Synuclein Meeting 2022 - Leuven, Belgium, 2022.
  10. Abreu, Daniela; Gomes, Joana I.; Sottomayor, Mariana; Ribeiro, Filipa Ferreira; Vicente Miranda, Hugo; Marques, Marta C; Summavielle, Teresa; et al. "Astrocyte's dysregulation: a central hub in Alzheimer's disease pathophysiology?". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  11. "Glycation modulates glutamatergic signalling and exacerbates Parkinson’s disease-like phenotypes". Paper presented in XVII Meeting of Portuguese Society for Neuroscience, 2021.
  12. "Mice overexpressing alpha-synuclein in the brain presente alterations in oxidative phosphorylation, endocytosis and synaptic vesicles dynamis in the midbrain". Paper presented in XVII Meeting of Portuguese Society for Neuroscience, 2021.
  13. "Unveiling insulin degrading enzyme as a new therapeutic target for Parkinson’s disease". Paper presented in XVII Meeting of Portuguese Society for Neuroscience, 2021.
  14. "Carotid sinus nerve resection prevents cognitive dysfunction in an animal model of dysmetabolism". Paper presented in SPN Meeting – Congress of Portuguese Neuroscience Society, 2021.
  15. "Glycation modulates glutamatergic signalling and exacerbates Parkinson’s disease-like phenotypes". Paper presented in European Physiology Day 2021, 2021.
  16. "Carotid sinus nerve resection prevents cognitive dysfunction in an animal model of dysmetabolism". Paper presented in European Physiology Day 2021, 2021.
  17. "Glycation induces Parkinson’s disease-like phenotypes in a mouse model of synucleinopathies via dysregulation of glutamatergic signaling and synaptic transmission - BEST POSTER PRIZE". Paper presented in ENCODS 2021 Virtual Meeting, 2021.
  18. Abreu, Daniela; Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Impact of astrocytes in neurotoxicity mediated by amyloid-ß: potential role of D-serine". Paper presented in AIMS Meeting – Annual International (bio)Medical Students Meeting, 2021.
  19. Marçal, A. R.; Sousa, L; Guarda, M; Chegão, Ana; Macedo, MP; Vicente Miranda, Hugo. "Underlying association between Parkinson’s disease and type-II diabetes mellitus: Insulin degrading enzyme as a therapeutic target". Paper presented in iMed Conference, 2020.
  20. Ana Chegão; Joana E Coelho; Inês Marques-Morgado; Mariana Guarda; Luísa V. Lopes; Tiago Fleming Outeiro; Vicente Miranda, Hugo. "Glycation impairs motor, cognitive and olfactory performance in a mouse model of synucleinopathy". Paper presented in FENS 2020 Virtual Forum, 2020.
  21. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "On the role of astrocytic signaling in Aß triggered synaptic deficits .". Paper presented in 12th FENS Forum of Neuroscience, Virtual Forum, 2020.
  22. Guarda, Mariana; Sousa, L.; De Oliveira, R. M.; Chegão, A.; Sousa-Lima, I.; Marçal, A.; Macedo, Maria Paula; Vicente Miranda, Hugo. "Murganhos alimentados com uma dieta rica em gorduras apresentam níveis diminuídos do enzima que degrada a insulina e acumulação de alfa-sinucleína no cérebro ("High fat diet mice present decreased levels of Insulin Degrading Enzyme and alpha-synuclein accumulation in the brain")". Paper presented in 16 ª Congresso Português de Diabetes (SPD), 2020.
  23. Sousa, L.; Guarda, M.; de Oliveira, R. M.; Chegão, Ana; Sousa-Lima, I.; Marçal, A. R.; Macedo, Maria Paula; Vicente Miranda, Hugo. "Murganhos alimentados com uma dieta rica em gorduras apresentam níveis diminuídos do enzima que degrada a insulina e acumulação de alfa-sinucleína no cérebro". Paper presented in 16º Congresso Português de Diabetes, 2020.
  24. Sousa, Luís; Guarda, Mariana; de Oliveira, R. M.; Chegão, Ana; Sousa-Lima, I; Marçal, Ana Rita; Macedo, Maria Paula; Vicente Miranda, Hugo. "Mice under high-fat diet show reduced levels of insulin degrading enzyme and accumulation of alpha-synuclein in the brain". Paper presented in 16th Portuguese Congress of Diabetes, 2020.
  25. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of tripartite synapse upon Aß-mediated synaptic deficits". Paper presented in 5th PhD Students Meeting of Mind-Brain College of Universidade de Lisboa, 2019.
  26. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of astrocytic signaling upon Aß-induced synaptic deficits.". Paper presented in AstraZeneca Foundation Innovate Competition, iMed Conference ® 11.0, 2019.
  27. Guarda, Mariana; Chegão, Ana; Fernandes Gomes, Bárbara; de Oliveira, R. M.; Sousa, L.; Sousa-Lima, I.; Macedo, M. P.; Vicente Miranda, Hugo. "Unveiling insulin degrading enzyme as a novel therapeutic target for Parkinson’s disease". Paper presented in iMED conference, 2019.
  28. Chegão, Ana; Fernandes Gomes, Bárbara; Outeiro, Tiago Fleming; Vicente Miranda, Hugo. "Metformin prevents the deleterious effects of glycation in cellular models of synucleinopathies | Corresponding Author". Paper presented in Synuclein Meeting 2019, 2019.
  29. Vicente Miranda, Hugo; Chegão, Ana; Oliveira, Márcia; Fernandes Gomes, Bárbara; Outeiro, Tiago Fleming. "Hsp27 prevents the deleterious effects of glycation in alpha-synuclein pathobiology | Corresponding Author". Paper presented in Synuclein Meeting 2019, 2019.
  30. Gomes, Joana; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastiao, A. M.; Diogenes, M. J.; Vaz, S. H.. "On the role of astrocytes upon Aß-mediated neurotoxicity". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  31. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of astrocytic signaling on AD-like conditions.". Paper presented in IV Symposium of the Portuguese Glial Network: Glia Diversity in Neuromodulation and Neurodegeneration, 2019.
  32. Vicente Miranda, Hugo. "Development of a novel therapeutic strategy to prevent the loss of BDNF signaling in Alzheimer’s disease". Paper presented in The 14th international conference on Alzheimer's and Parkinson's diseases, 2019.
  33. Vicente Miranda, Hugo; Chegão, Ana; Oliveira, Márcia; Fernandes Gomes, Bárbara; Outeiro, Tiago Fleming. "Hsp27 prevents the deleterious effects of glycation in Parkinson’s disease models | Corresponding author". Paper presented in The 14th international conference on Alzheimer's and Parkinson's diseases, 2019.
  34. Chegão, Ana; Fernandes Gomes, Bárbara; Outeiro, Tiago Fleming; Vicente Miranda, Hugo. "Metformin prevents the deleterious effects of glycation in cellular models of Parkinson’s disease. | Corresponding author". Paper presented in The 14th international conference on Alzheimer's and Parkinson's diseases, 2019.
  35. Vicente Miranda, Hugo; Chegão, Ana; Oliveira, M.; Gomes, B.; Outeiro, T. F.. "Hsp27 prevents the deleterious effects of glycation in Parkinson’s disease models.". Paper presented in AD/PD 2019: The 14th International Conference on Alzheimer’s & Parkinson’s Diseases, 2019.
  36. Van Zeller, Mariana; Diogo Dias; Vicente Miranda, Hugo; Valente, Cláudia A; Sebastião, AM. "Relevance of NLRP3 inflammasome in A1 astrocytes - impact of Aß-induced toxicity". Paper presented in 5th Meeting of the Mind-Brain College, 2019.
  37. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Role of astrocytes upon amyloid-ß (Aß) neurotoxic pathways.". Paper presented in 3rd SynaNet Annual Meeting, Neurologic and Psychiatric Disorders: from synapses to networks, 2018.
  38. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Role of SNARE-dependent gliotransmitters release from astrocytes upon amyloid-ß mediated neurotoxicity.". Paper presented in 4th PhD Students Meeting of Mind-Brain College of Universidade de Lisboa, 2018.
  39. Vicente Miranda, Hugo. "Metformin prevents the deleterious effects of glycation in cellular models of Parkinson’s disease. Workshop on integrative approaches in neurodegeneration.". Paper presented in FlySMALS consortium, Funded by European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases, 2018.
  40. Vicente Miranda, Hugo. "Metformin prevents the deleterious effects of glycation in cellular models of Parkinson’s disease.". Paper presented in 2nd NMS Symposium on Chronic Diseases and Translational Science, 2018.
  41. Vicente Miranda, Hugo. "a-synuclein posttranslational modifications as blood biomarkers for Parkinson's disease". Paper presented in ADPD, Mar 28 - Apr 3, Vienna, Austria., 2017.
  42. Vicente Miranda, Hugo. "PRPC mediates synaptic damage triggered by a-synuclein oligomers". Paper presented in ADPD, Mar 28 - Apr 3, Vienna, Austria., 2017.
  43. Vicente Miranda, Hugo. "Yeast uncover glycation as a modulator of a-synuclein-associated neurodegeneration". Paper presented in FENS, Jul 2-6, Copenhagen, Denmark., 2016.
  44. Vicente Miranda, Hugo. "Adenosine A2A receptors modulate alpha-synuclein toxicity and aggregation". Paper presented in Reunião da Sociedade Portuguesa de Farmacologia, Lisboa, Portugal, 2015.
  45. Vicente Miranda, Hugo. "Alpha-synuclein oligomers fail to induces synaptic dysfunction in adenosine A2A receptor knockout-mice". Paper presented in 9th FENS Forum of Neuroscience, Milan, Italy, 2014.
  46. Vicente Miranda, Hugo. "Glycation Modulates Huntingtin Aggregation and Toxicity". Paper presented in EHDN Plenary meeting, Barcelona, Spain., 2014.
  47. Vicente Miranda, Hugo. "Adenosine A2A receptor blockade prevents LTP impairment induced by a-synuclein". Paper presented in XIII Reunião da Sociedade Portuguesa de Neurociências (SPN), Luso, Portugal, 2013.
  48. Vicente Miranda, Hugo. "Heat-mediated enrichement of a-synuclein from cells and tissue for assessing post-translational modifications.". Paper presented in Portuguese Society for Neurosciences (SPN) meeting 2013, Luso, Portugal. May 30–June 1, 2013, 2013.
  49. Vicente Miranda, Hugo. "Adenosine A2A receptor blockade prevents LTP impairment induced by alpha-synuclein". Paper presented in XIII Reunião da Sociedade Portuguesa de Neurociências, Luso, Portugal. May 30–June 1, 2013, 2013.
  50. Vicente Miranda, Hugo. "Alpha-synuclein secretion: regulatory mechanisms and role in microglia activation and neurodegeneration in Parkinson’s disease". Paper presented in 8th FENS forum of Neuroscience, Barcelona July 14-18, Spain., 2012.
  51. Vicente Miranda, Hugo. "A method for rapid enrichment and characterization of post-translational modifications of the Parkinson’s associate protein alpha-synuclein,". Paper presented in I NeuroSeS Annual Symposium, Instituto de Medicina Molecular, Lisbon June 11, Portugal., 2011.
  52. Vicente Miranda, Hugo. "The role of alfa-synuclein secretion in microglia activation and neurodegeneration in Parkinson’s disease". Paper presented in XII Meeting Portuguese Society for Neurosciences, Instituto de Medicina Molecular, Lisbon May 26-28, Portugal. P-58., 2011.
  53. Vicente Miranda, Hugo. "SIRT2: Crossing the bridge between ageing and neurodegeneration". Paper presented in XII Meeting Portuguese Society for Neurosciences, Instituto de Medicina Molecular, Lisbon May 26-28, Portugal. P-17., 2011.
  54. Vicente Miranda, Hugo. "A method for rapid enrichment and characterization of post-translational modifications of the Parkinson’s associate protein alpha-synuclein". Paper presented in XII Meeting Portuguese Society for Neurosciences, Instituto de Medicina Molecular, Lisbon May 26-28, Portugal. P-4., 2011.
  55. Vicente Miranda, Hugo. "Yeast as a model to investigate the role and regulation of alpha-synuclein phosphorylation in Parkinson's disease.". Paper presented in The 24th International Conference on Yeast Genetics & Molecular Biology, Manchester, United Kingdom., 2009.
  56. Vicente Miranda, Hugo. "Parameter estimation in multi-enzyme systems using time-course analysis and in situ techniques". Paper presented in The 25th International Specialised Symposium on Yeasts, ISSY25, Finland., 2006.
  57. Vicente Miranda, Hugo. "MAGE in yeast: a cellular model of protein glycation in vivo.". Paper presented in The 25th International Specialised Symposium on Yeasts, ISSY25, Finland., 2006.
  58. Vicente Miranda, Hugo. "Advanced glycation end-products in yeast: formation and defence mechanisms". Paper presented in XIV Congresso Nacional de Bioquímica, Vilamoura - Portugal., 2004.
Journal article
  1. Vicente Miranda, Hugo. "TOTAL NUMBER OF ARTICLES: 35, Accumulated IF: 193 , Average IF: 6 | SINCE 2017: 16 Published Papers with Average IF 7 (6 papers with IF >9), 8 as Senior author | CITATIONS: >2570 (Google Scholar) | >1760 (Web of Science) | >1800 (SCOPUS) | h-index 20 (Clarivate & SCOPUS)". (2025):
  2. Chegão A; Fernandes Gomes B; Outeiro TF; Vicente Miranda, Hugo. "Metformin prevents the deleterious effects of glycation in cellular models of Parkinson's disease. (Under Preparation)". N/A N/A (2025): N/A-N/A.
  3. Chegão, Ana; Alexandre, Bruno M; Matthiesen, Rune; Lopes, Luísa V.; Anjos-Gomes, Ricardo; GOMES-ALVES, Patrícia; Coelho, Joana Esteves ; Outeiro, Tiago Fleming; Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. "aSyn overexpression impairs oxidative phosphorylation, endocytosis, and synaptic vesicle dynamics in the midbrain (Under Preparation)". npj Parkinson's Disease (2025):
    Submitted
  4. Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, Nuno; Atalaia-Barbacena, Henrique; et al. "A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease". Molecular Therapy 32 10 (2024): 3372-3401. https://doi.org/10.1016/j.ymthe.2024.08.022.
    Open access • Published • 10.1016/j.ymthe.2024.08.022
  5. Xiang, Wei; Vicente Miranda, Hugo. "Unraveling the complexity of alpha-synucleinopathies: Insights from the special issue “alpha synuclein and synucleinopathies”". Behavioural Brain Research 460 (2024): 114797. https://doi.org/10.1016/j.bbr.2023.114797.
    10.1016/j.bbr.2023.114797
  6. Chegão, Ana; Vicente Miranda, Hugo. "Unveiling new secrets in Parkinson's disease: The glycatome - CORRESPONDING AUTHOR". Behavioural Brain Research 442 (2023): 114309. http://dx.doi.org/10.1016/j.bbr.2023.114309 | IF=3.65 (2021).
    Open access • Published • 10.1016/j.bbr.2023.114309
  7. Capucho, Adriana M.; Chegão, Ana; Martins, Fátima O.; Melo, Bernardete F.; Madeira, Natália; Sacramento, Joana F.; Fonseca, Rosalina; Vicente Miranda, Hugo; Conde, Sílvia V.. "Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changing Insulin Signaling in the Hippocampus and Prefrontal Cortex". Advances in Experimental Medicine and Biology (2023): 143-152. http://dx.doi.org/10.1007/978-3-031-32371-3_16.
    10.1007/978-3-031-32371-3_16
  8. Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, Bárbara; et al. Corresponding author: Vicente Miranda, Hugo. "Glycation modulates glutamatergic signaling and exacerbates Parkinsons disease-like phenotypes. CORRESPONDING AUTHOR". npj Parkinson's Disease 8 1 (2022): http://dx.doi.org/10.1038/s41531-022-00314-x | IF = 9.3 (2021) | Citations: 5 (Google Scholar) 4 (Clarivate) 4 (SCOPUS) | TOP 6% Q1 Medicine (Neurology - clinical).
    Published • 10.1038/s41531-022-00314-x
  9. Capucho, Adriana M.; Chegão, Ana; Martins, Fátima O.; Vicente Miranda, Hugo; Conde, Sílvia V.. "Dysmetabolism and Neurodegeneration: Trick or Treat?". Nutrients 14 7 (2022): 1425. http://dx.doi.org/10.3390/nu14071425 - IF = 6.7 (2021) | Citations: 6 (Google Scholar) 5 (Clarivate) 5 (SCOPUS) | TOP 6% Q1 Agricultural and Biological Sciences (Food Science) (SCIMago).
    Published • 10.3390/nu14071425
  10. Vicente Miranda, Hugo. "Can We Prevent the Development of Parkinson’s Disease in Type-2 Diabetes Mellitus Patients?". Revista Portuguesa de Diabetes 16 4 (2021): 162-163. http://www.revportdiabetes.com/wp-content/uploads/2022/01/RPD_DEZ_2021_Editorial_Hugo_Vicente_Miranda_162-163.pdf.
    Open access • Published
  11. Sousa, Luís; Guarda, Mariana; Meneses, Maria João; Macedo, M Paula; Vicente Miranda, Hugo. "Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases CORRESPONDING AUTHOR". The Journal of Pathology 255 4 (2021): 346-361. http://dx.doi.org/10.1002/path.5777 | IF 2021: 9.883 | Citations: 23 (Google Scholar) 19 (Clarivate) 21 (SCOPUS) | 6th Best, TOP 3% in Medicine - Pathology and Forensic Medicine (SCImago-2021).
    10.1002/path.5777
  12. Ana Chegão; Mariana Guarda; Alexandre BM; Shvachiy, Liana; Mariana Temido-Ferreira; Inês Marques-Morgado; Bárbara Fernandes Gomes; et al. Corresponding author: Vicente Miranda, Hugo. "Exacerbation of Parkinson’s disease-like phenotypes by glycation involves glutamatergic signaling". BioRxiv (2021): https://doi.org/10.1101/2021.08.24.457507.
    Published
  13. Miranda, H.V.; Szego, ÉM.; Oliveira, L.M.A.; Breda, C.; Darendelioglu, E.; de Oliveira, R.M.; Ferreira, D.G.; et al. "Erratum to: Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". Brain : a journal of neurology 144 6 (2021): e58-e58. http://www.scopus.com/inward/record.url?eid=2-s2.0-85112862951&partnerID=MN8TOARS.
    10.1093/brain/awab175
  14. Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.00985 | IF 5.811, IF (5 years) 5.553 | Citations: 8 (Google Scholar) 6 (Clarivate) 6 (SCOPUS) | Q1 Pharmacology (SCIMago).
    Open access • 10.3389/fphar.2020.00985
  15. Vicente Miranda, Hugo; Chegão, Ana; Oliveira, Márcia S.; Fernandes Gomes, Bárbara; Enguita, Francisco J.; Outeiro, Tiago Fleming. "Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein *CORRESPONDING AUTHOR". The FASEB Journal Epub ahead of (2020): print. http://dx.doi.org/10.1096/fj.201902936r | IF 2020: 5.2 | Citations: 17 (Google Scholar) 14 (Clarivate) 13 (SCOPUS) | TOP 6% in Medicine (SCImago-2020) | *Corresponding author.
    Open access • Published • 10.1096/fj.201902936r
  16. Vicente Miranda, Hugo; Ana Chegão; Bárbara Fernandes Gomes; Francisco J. Enguita; Tiago Fleming Outeiro. "Hsp27 reduces glycation-induced toxicity and aggregation of a-synuclein *CORRESPONDING AUTHOR". bioRxiv 2020.03.03 975037 (2020): https://www.biorxiv.org/content/10.1101/2020.03.03.975037v1.
    Open access • Published
  17. Gomes, J. I.; Fonseca Gomes, J.; Vicente Miranda, Hugo; Sebastiao, A. M.; Diogenes, M. J.; Vaz, S. H.. "Astrocytic signaling upon Aß-mediated excitotoxicity". Frontiers in Cellular Neuroscience (2019): https://www.frontiersin.org/10.3389/conf.fncel.2019.01.00023/event_abstract.
    Published
  18. Hoffmann, Anna-Carin; Minakaki, Georgia; Menges, Stefanie; Salvi, Rachele; Savitskiy, Sergey; Kazman, Aida; Vicente Miranda, Hugo; et al. "Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-018-35811-8 | IF=4.1; TOP 5%, | TOP 5% Q1 Multidisciplinary (SCImago-2018) | Citations: 105 (Google Scholar) 73 (Clarivate) 74 (SCOPUS).
    Published • 10.1038/s41598-018-35811-8
  19. König, Annekatrin; Vicente Miranda, Hugo; Outeiro, Tiago Fleming. "Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's disease". Journal of Parkinson's disease 8 1 (2018): 33-43. http://dx.doi.org/10.3233/jpd-171285 | IF 2018: 3.698; last 5-year = 5.121 (ISI) Citations: 43 (Google Scholar) 27 (Clarivate) 32 (SCOPUS) | Q1 Neurology (clinical) (SCImago-2018).
    10.3233/jpd-171285
  20. Vicente Miranda, Hugo; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease. *CORRESPONDING AUTHOR". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-14175-5 | IF 2017: 4.122; last 5-year = 4.609 (ISI) Citations: 78 (Google Scholar); 59 (Clarivate); 58 (SCOPUS) | TOP 5%, Q1, Multidisciplinary (SCImago-2017).
    Open access • Published • 10.1038/s41598-017-14175-5
  21. Ferreira, Diana G; Temido-Ferreira, Mariana; Miranda, Hugo Vicente; Batalha, Vânia L; Coelho, Joana E; Szegö, Éva M; Marques-Morgado, Inês; et al. "a-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B.". Nature Neuroscience 20 11 (2017): 1569-1579. http://dx.doi.org/10.1038/nn.4648 | IF 2017: 19.9; last 5-year = 19.2 (ISI) Citations: 228 (Google Scholar); 160 (Clarivate); 164 (SCOPUS) | TOP 1%, Second Best - Q1 Neuroscience (SCImago-2016).
    10.1038/nn.4648
  22. Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies.". Brain 140 5 (2017): 1399-1419. http://dx.doi.org/10.1093/brain/awx056 | IF 2017: 11; last 5-year = 11.2 (ISI) Citations: 165 (G. Scholar) 116 (Scopus) 111 (Clarivate) TOP 1%, Third Best Journal in Neurology (SCIMago).
    10.1093/brain/awx056
  23. de Oliveira, Rita Machado* Co-first; Vicente Miranda, Hugo *Co-first; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLOS Biology 15 4 (2017): e1002601. http://dx.doi.org/10.1371/journal.pbio.1002601.
    Published • 10.1371/journal.pbio.1002601
  24. de Oliveira, Rita Machado* Co-first; Vicente Miranda, Hugo* Co-first; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2 mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLOS Biology 15 3 (2017): e2000374. http://dx.doi.org/10.1371/journal.pbio.2000374 | IF 2017: 9.2; last 5-year = 10.2 (ISI) Citations: 130 (Google Scholar); 88 (Clarivate); 98 (Scopus) | TOP 1%, Second Best - Agricultural and Biological Sciences (miscellaneous) (SCIma.
    Published • 10.1371/journal.pbio.2000374
  25. Ferreira, Diana G.; Batalha, Vânia L.; Vicente Miranda, Hugo; Coelho, Joana E.; Gomes, Rui; Gonçalves, Francisco Q.; Real, Joana I.; et al. "Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity". Cerebral Cortex 27 1 (2017): 718-730. http://dx.doi.org/10.1093/cercor/bhv268 | IF 2015 - 8.3; last 5-year - 7.9 (ISI) Citations: 78 (Google Scholar); 54 (Clarivate), 53 (Scopus) | TOP 5%, Fourth Best - Cell and Molecular Neuroscience (SCImago - 2015).
    Published • 10.1093/cercor/bhv268
  26. Goreti Ribeiro Morais []; Elisa Palma; Fernanda Marques; Lurdes Gano; Maria Cristina Oliveira; Antero Abrunhosa; Hugo Vicente Miranda; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry (2017): n/a-n/a. http://dx.doi.org/10.1002/jhet.2575 | IF 2016 0.893; last 5-year 0.866 (ISI) | Citations: 11 (Google Scholar); 7 (Clarivate); 7 (SCOPUS) | Q3 Organic Chemistry (SCImago-2016).
    10.1002/jhet.2575
  27. Vicente Miranda, Hugo; Gomes, Marcos António; Branco-Santos, Joana; Breda, Carlo; Lázaro, Diana F.; Lopes, Luísa Vaqueiro; Herrera, Federico; Giorgini, Flaviano; Outeiro, Tiago Fleming. "Glycation potentiates neurodegeneration in models of Huntington's disease". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep36798 | IF 2016: 4.3; last 5-year = 4.9 (ISI) Citations: 29 (Google Scholar); 21 (Clarivate); 20 (Scopus) | TOP 5%, Fifth Best - Q1 Multidisciplinary (SCImago-2016).
    Published • 10.1038/srep36798
  28. Outeiro, Tiago Fleming; Vicente Miranda, H. "B7 Glycation potentiates neurodegeneration in models of huntington’s disease". Journal of Neurology, Neurosurgery & Psychiatry 87 Suppl 1 (2016): A11.2-A11. http://dx.doi.org/10.1136/jnnp-2016-314597.38 | IF (2016): 7.349, IF (last 5-year): 7.160 (ISI) TOP 3% - Q1, #211 in 6670 - Medicine (Scimago-2016).
    10.1136/jnnp-2016-314597.38
  29. Vicente Miranda, Hugo; El-Agnaf, Omar M. A.; Outeiro, Tiago Fleming. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders 31 6 (2016): 782-790. http://dx.doi.org/10.1002/mds.26566 | IF 2016 = 7.1; last 5-year = 6.4 (ISI) | Citations: 129 (Google Scholar); 88 (Clarivate); 92 (Scopus) | TOP 5% - Q1 Neurology (clinical) (SCImago-2016).
    Published • 10.1002/mds.26566
  30. Nunes, Patrique; Morais, Goreti Ribeiro; Palma, Elisa; Silva, Francisco; Oliveira, Maria Cristina; Ferreira, Vera F. C.; Mendes, Filipa; et al. "Isostructural Re(i)/99mTc(i) tricarbonyl complexes for cancer theranostics". Organic & Biomolecular Chemistry 13 18 (2015): 5182-5194. http://dx.doi.org/10.1039/c5ob00124b | IF 2015 = 3.6; last 5-year = 3.4 (ISI) Citations: 18 (Google Scholar); 16 (Clarivate); 17 (Scopus) | Q1 Biochemistry (SCImago - 2015).
    Published • 10.1039/c5ob00124b
  31. Macedo, Diana; Tavares, Lucélia; McDougall, Gordon J.; Vicente Miranda, Hugo; Stewart, Derek; Ferreira, Ricardo B.; Tenreiro, Sandra; Outeiro, Tiago F.; Santos, Cláudia N.. "(Poly)phenols protect from a-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics 24 6 (2014): 1717-1732. http://dx.doi.org/10.1093/hmg/ddu585 | IF 2014 = 6.4; last 5-year = 6.9 (ISI) Citations: 73 (Google Scholar); 58 (Clarivate); 61 (Scopus) | TOP 5% - Q1 Genetics (SCImago - 2014).
    Published • 10.1093/hmg/ddu585
  32. Vicente Miranda, H.; Gomes, M.; Branco dos Santos, J.; Giorgini, F.; Outeiro, T.. "B08 Glycation Modulates Huntingtin Aggregation And Toxicity". Journal of Neurology, Neurosurgery & Psychiatry 85 Suppl 1 (2014): A11-A11. http://dx.doi.org/10.1136/jnnp-2014-309032.36 | IF (2014): 6.81, IF (last 5-year): 5.577 (ISI) TOP 3% - Q1, #215 in 6613 - Medicine (Scimago-2015).
    Published • 10.1136/jnnp-2014-309032.36
  33. Vicente Miranda, H; Xiang, Wei; de Oliveira, Rita M.; Simões, Tânia; Pimentel, José; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago F.. "Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry 126 5 (2013): 673-684. http://dx.doi.org/10.1111/jnc.12251 | IF 2013 - 4.244; last 5-year = 4 (ISI) Citations: 26 (Google Scholar); 15 (Clarivate), 17 (Scopus) | Q1 Biochemistry (SCImago - 2013).
    Published • 10.1111/jnc.12251
  34. Diogenes, M. J.; Dias, R. B.; Rombo, D. M.; Vicente Miranda, H.; Maiolino, F.; Guerreiro, P.; Nasstrom, T.; et al. "Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation". Journal of Neuroscience 32 34 (2012): 11750-11762. http://dx.doi.org/10.1523/jneurosci.0234-12.2012 | IF 2012 = 6.9; last 5-year = 7.4 (ISI) Citations: 268 (Google Scholar); 191 (Clarivate); 193 (Scopus) | Q1, (6.5%) - Neurosciences (miscellaneous) (SCImago - 2012).
    Published • 10.1523/jneurosci.0234-12.2012
  35. Autio, Henri; Castren, Eero; Davis, Sabrina; Diogenes, Maria J; Jeronimo-Santos, Andre; Karkkainen, Elisa; Karpova, Nina; et al. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.". Neurobiology of aging 33 6 (2012): 1122.e23-39. https://doi.org/10.1016/j.neurobiolaging.2011.11.006 | IF 2012 = 6.2; last 5-year = 5.2 (ISI) Citations: 90 (Google Scholar); 62 (Clarivate); 62 (Scopus) | TOP 5% - Neurology (clinical) (SCImago - 2012).
    10.1016/j.neurobiolaging.2011.11.006
  36. Ribeiro Morais, Goreti; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic & Medicinal Chemistry 19 24 (2011): 7698-7710. http://dx.doi.org/10.1016/j.bmc.2011.09.065 | IF 2011 = 2.921; last 5-year = 3 (ISI) Citations: 33 (Google Scholar); 21 (Publons); 21 (Scopus) | Q1, Organic Chemistry (SCImago - 2011).
    Published • 10.1016/j.bmc.2011.09.065
  37. Vicente Miranda, Hugo; Outeiro, Tiago Fleming. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology 221 1 (2009): 13-25. http://dx.doi.org/10.1002/path.2682 | IF 2010: 7.274; last 5-year: 6.941 (ISI) Citations: 179 (Google Scholar); 116 (Clarivate); 125 (Scopus) | TOP 1%, Third Best Pathology and Forensic Medicine (SCImago - 2010).
    Published • 10.1002/path.2682
  38. Miranda, Hugo Vicente; Ferreira, António E. N.; Quintas, Alexandre; Cordeiro, Carlos; Freire, Ana Ponces. "Measuring intracellular enzyme concentrations". Biochemistry and Molecular Biology Education 36 2 (2008): 135-138. http://dx.doi.org/10.1002/bmb.20166 | IF 2008 - 0.635; last 5-year 0.707 (Clarivate) | Citations: 5 (Google Scholar); 1 (Clarivate); 3 (Scopus) | Q4, Biochemistry (SCImago - 2008).
    Published • 10.1002/bmb.20166
  39. Gomes, Ricardo Anjos; Miranda, Hugo Vicente; Sousa Silva, Marta; Graça, Gonçalo; Coelho, Ana Varela; do Nascimento Ferreira, António Eduardo; Cordeiro, Carlos; Freire, Ana Ponces. "Protein glycation and methylglyoxal metabolism in yeast: finding peptide needles in protein haystacks". FEMS Yeast Research 8 1 (2008): 174-181. http://dx.doi.org/10.1111/j.1567-1364.2007.00337.x | IF 2008 2.579, last 5-year 2.629 (clarivate) | Citations 32 (Google Scholar) 20 (Clarivate); 22 (Scopus) | Q1 applied Microbiology and Biotechnology (SCImago).
    Published • 10.1111/j.1567-1364.2007.00337.x
  40. Gomes, Ricardo A.; Miranda, Hugo Vicente; Silva, Marta Sousa; Graça, Gonçalo; Coelho, Ana V.; Ferreira, António E.; Cordeiro, Carlos; Freire, Ana Ponces. "Yeast protein glycation in vivo by methylglyoxal: Molecular modification of glycolytic enzymes and heat shock proteins". FEBS Journal 273 23 (2006): 5273-5287. http://dx.doi.org/10.1111/j.1742-4658.2006.05520.x | IF 2006 3.033, last 5-year 4.068 (ISI) | Citations: 96 (Google Scholar); 65 (Clarivate); 68 (Scopus) | Q1, Biochemistry (SCImago - 2006).
    Published • 10.1111/j.1742-4658.2006.05520.x
  41. Vicente Miranda, Hugo; Ferreira, António E.N.; Cordeiro, Carlos; Freire, Ana Ponces. "Kinetic assay for measurement of enzyme concentration in situ". Analytical Biochemistry 354 1 (2006): 148-150. http://dx.doi.org/10.1016/j.ab.2005.09.002 | IF 2006 ¿ 2.948; last 5-year ¿ 2.564 (ISI) Citations: 2 (1oogle Scholar), 2 (Clarivate), 1 (Scopus) | Q2 iochemistry (SCImago - 2006).
    Published • 10.1016/j.ab.2005.09.002
  42. Gomes, Ricardo A.; Sousa Silva, Marta; Vicente Miranda, Hugo; Ferreira, Antonio E. N.; Cordeiro, Carlos A. A.; Freire, Ana Ponces. "Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism.". FEBS Journal 272 17 (2005): 4521-4531. http://dx.doi.org/10.1111/j.1742-4658.2005.04872.x | IF:4.1 (Clarivate). Q1 - Biochemistry (SCIMago) | Citations: 65 (Google Scholar); 42 (Clarivate); 44 (Scopus) | Q1 Biochemistry (SCImago - 2005).
    Published • 10.1111/j.1742-4658.2005.04872.x
Online resource
  1. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. World diabetes Day 2021. 2021. https://www.youtube.com/watch?v=whelUALDWQg.
  2. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Social Media Day. 2021. https://www.youtube.com/watch?v=IszEhLuqlVk&t=1s.
  3. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. World Parkinson's disease Day 2021 - Documentary. 2021. https://www.youtube.com/watch?v=B8oeuXAz7gY.
  4. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Hsp27 protection in Parkinson's disease. 2020. https://youtu.be/0Huf1fzIrOc.
  5. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Ana Chegão was awarded an EMBO short-term fellowship. 2020. https://youtu.be/6gJnrdcEQsM.
  6. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. World Parkinson's day 2020 @DysBrainD. 2020. https://youtu.be/c0h6td_RnKc.
  7. Vicente Miranda, Hugo. World Diabetes Day 2019 - Youtube Video. 2019. https://www.youtube.com/watch?v=zI4HqCml4YI&t=88s.
  8. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Dia Mundial da Diabetes 2019 - Youtube Video. 2019. https://www.youtube.com/watch?v=KTdui_QkmC0&t=59s.
  9. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Biomarkers for Parkinson's Disease - Youtube Video. 2017. https://www.youtube.com/watch?v=T3PJKuMXD6s.
  10. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. Biomarcadores para a doença de Parkinson - Youtube Video. 2017. https://www.youtube.com/watch?v=btAdfCPVi3M.
Thesis / Dissertation
  1. "Evaluating insulin-degrading enzyme role in the onset and development of Parkinson's disease - Soraia Chôcho (Scored 19 out of 20)". Master, Universidade Nova de Lisboa Medical School, 2025.
  2. "Type 2 diabetes mellitus as a risk factor for Parkinson's disease - Bruna Luzio (19 out of 20)". Master, Universidade Nova de Lisboa Medical School, 2024.
  3. "Therapeutic potential of anti-glycation compounds in animal models of Parkinson's disease - Rafaela Pina (Scored 17 out of 20)". Master, Universidade Nova de Lisboa Medical School, 2024.
  4. "Underlying role of glycation in the pathogenesis of Parkinson's disease - Ana Chegão Thesis Completed in December 2022". PhD, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2022.
  5. "The role of carotid body in brain insulin resistance and Neurodegeneration - Adriana Capucho - Rank 20 out of 20!". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2022.
  6. "Role of SNARE-dependent Gliotransmitters Release in Alzheimer¿s Disease: from astrocytes to circuits - Daniela Abreu - Scored 19 out of 20". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021.
  7. Vicente Miranda, Hugo. "Insulin-Degrading enzyme as a suppressor of alpha-synuclein pathogenesis - Ana Rita Marçal - Scored 19 out of 20". Master, Universidade de Lisboa Faculdade de Ciências, 2021. SUPERVISOR.
  8. "Nanoparticle and liposome-based microreactors as reactive oxygen species scavengers in neuroinflammation 3D models - Oksana Savchak - Scored 19 out of 20". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021.
  9. "Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signaling in Alzheimer¿s Disease - Tiago Coelho - Scored 19 out of 20". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021.
  10. Vicente Miranda, Hugo. "Insulin degrading enzyme as a therapeutic target for Parkinson¿s disease - Mariana Guarda - Scored 17 out of 20". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2019. SUPERVISOR.
  11. Miranda, Hugo Miguel Vicente,1982-; Caeiro, Filomena,1950-; Gomes, Bárbara Alexandra Fernandes. "Targeting the glycation defenses as a protective strategy for Parkinson's disease - Bárbara Fernandes Gomes - Scored 20 out of 20!!". Master, 2017. http://hdl.handle.net/10451/30537.
  12. Vicente Miranda, Hugo. "Alpha-Synuclein as a blood biomarker for Parkinson¿s disease - Rafaela Cássio - Scored 19 out of 20". Master, Instituto de Medicina Molecular, 2015. SUPERVISOR.
  13. Outeiro, Tiago; Miranda, Hugo; Oliveira, Márcia Santos. "Modulation of a-synuclein aggregation and toxicity - Márcia Oliveira - Scored 18 out of 20". Master, Instituto de Medicina Molecular, 2013. http://hdl.handle.net/10362/11195 SUPERVISOR.
  14. Quintas, Alexandre; Miranda, Hugo Miguel Vicente, 1982-. "Protein glycation and methylglyoxal metabolism in Parkinson's disease - Hugo Vicente Miranda". PhD, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2010. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000572162.
  15. Vicente Miranda, Hugo. "Methylglyoxal metabolism and protein glycation in Saccharomyces cerevisiae - Hugo Vicente Miranda - Scored 20 out of 20!!". Degree, Universidade de Lisboa Faculdade de Ciências, 2005.
Website
  1. Vicente Miranda, Hugo. Corresponding author: Vicente Miranda, Hugo. DysBrainD: Dysmetabolism in Brain diseases. 2018. https://nms.unl.pt/pt-pt/investigacao/grupos-de-investigacao/detalhe/n/dysbraind-dismetabolismo-em-doencas-do-cerebro.
Working paper
  1. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. 2021. "Astrocytic dn-SNARE expression prevents acute Aß effects in synaptic plasticity.".

Other

Other output
  1. Glycation modulates glutamatergic signalling and exacerbates Parkinson’s disease-like phenotypes. 2021. Chegão, A.; Guarda, M.; Alexandre, B.M.; Shvachiy, L.; Temido-Ferreira, M.; Marques-Morgado, I.; Gomes, B.F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115087484&partnerID=MN8TOARS.
    10.1101/2021.08.24.457507
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/04 Diabetes-Driven Neurodegeneration: IDE Deficiency and High-Fat Diet as Key Contributors to Parkinson’s Disease Neuropathology Synuclein Meeting 2025 - Cambridge, UK
Cambridge University (Cambridge, United Kingdom)
2024/06/27 A novel link between type-2 diabetes mellitus and Parkinson's disease: the role of glycation and insulin-degrading enzyme dysfunction 4th Chem & Biochem Students Meeting
Universidade de Lisboa, Faculdade de Ciências
2024/04/20 À procura de soluções terapêuticas para a doença de Parkinson. (Searching for therapeutic solutions for Parkinson's disease) Dia Mundial de Conscientização da Doença de Parkinson
Associação Parkinson Porto
2023/06/07 The sour side of Diabetes: Is Parkinson's disease a brain comorbidity? ESCI Annual Scientific Meeting
European Society for Clinical Investigation (ESCI) (Prague, Czech Republic)
2022/12/07 Links between Diabetes and Parkinson's disease: myth or reality? International Diabetes Federation World Congress
International Diabetes Federation (IDF) (Lisbon, Portugal)
2022/10/26 Glycatome: an underlying link between sugars and Brain diseases Aveiro IBIMED Seminers
IBIMED (Aveiro, Portugal)
2022/10/22 Carotid body modulation prevents cognitive dysfunction and neurodegenerative processes in prediabetic rats - Adriana Capucho (MSc student) 15th International Symposium “Molecular basis of pathology and therapy in neurological disorders”
(Warsaw, Poland)
2022/03 Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes International conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (AD/PD), Barcelona, Spain
Barcelona, Spain (Barcelona, Spain)
2021/10/13 Brain glycation exacerbates Parkinson's disease-like phenotypes by dysregulating glutamatergic-related proteins in the midbrain - RISING STAR AWARD - Ana Chegão (PhD student) 3rd NMS Symposium on Chronic Diseases and Translational Science
Virtual Meeting
2021/10/13 Carotid sinus nerve resection prevents cognitive dysfunction in an animal model of dysmetabolism - BEST 3 MINUTES FLASH TALK - Adriana Capucho (MSc student) 3rd NMS Symposium on Chronic Diseases and Translational Science
Virtual Meeting
2021/10/12 Glycation modulates glutamatergic signalling and exacerbates Parkinson¿s disease-like phenotypes - BEST TALK PRIZE - Ana Chegão (PhD student) European Physiology Day 2021
Virtual Meeting
2021/10/12 Carotid sinus nerve resection prevents cognitive dysfunction in an animal model of dysmetabolism - 2nd BEST TALK PRIZE - Adriana Capucho (MSc Student) European Physiology Day 2021
Virtual Meeting
2021/05/17 Thinking head (Cabecinha Pensadora) [Invited Speaker] Pint of Science
Pint of Science - Lisbon, Portugal (Lisbon, Portugal)
2021/02/08 Zooming in on the effects of Diabetes in Parkinson’s disease neuropathology [Invited Speaker] Neuroscience Seminar
Instituto de Medicina Molecular João Lobo Antunes (Lisboa, Portugal)
2021 Where did your Postdoc take you? ¿ [Invited Speaker] PostDoc Appreciation Week
i3s and COLife
2020/05/06 Crosstalk between Diabetes and Parkinson's disease [Invited Speaker] University of Leicester - Seminars
Department of Genetics and Genome Biology, University of Leicester (Leicester, United Kingdom)
2020/03/06 Brain glycation potentiates motor, cognitive and olfactive dysfunction in mice overexpressing alpha-synuclein Portuguese Congress of Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2020/03/06 Regulation of insulin degrading enzyme has therapeutic potential in a cellular model of Parkinson's disease 16th Portuguese Congress of diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2020/02/13 Round Table - Studying abroad [Invited Speaker] 2nd Meeting of Biochemistry MSc programme
Faculdade de Ciências - Universidade de Lisboa (Lisboa, Portugal)
2019/10/30 Papel da Investigação laboratorial no desenvolvimento de novas terapias "Role of laboratory research in the development of new therapies" [Invited Speaker] AIMS Masterclass - Changing the World and Medicine
Faculdade de Medicina, Universidade de Lisboa (Lisboa, Portugal)
2019/10/11 Lessons From Diabetes: Novel Parkinson's disease causative factors [Invited Speaker] Friedrich-Alexender Universitat Erlangen-Nürnberg, Universitätsklinikum Erlangen - Lectures
For!nter - BAVARIAN RESEARCH ASSOCIATION INTERACTION OF HUMAN BRAIN CELLS (Erlangen, Germany)
2019/04/11 Unveiling therapeutic solutions for Parkinson's disease [Invited Speaker] World day of Parkinson's disease
Portuguese Association of Parkinson's disease (Lisboa, Portugal)
2019/03/08 Anti-glycation drugs as therapeutic strategy for Parkinson's disease [Selected Speaker] 15º Congresso da Sociedade Portuguesa de Diabetologia
Tivoli Marina Hotel (Vilamoura, Portugal)
2018/10/18 Metformin prevents the deleterious effects of glycation in cellular models of Parkinson's disease NOVA Medical School Symposium
Universidade Nova de Lisboa, Faculdade de Ciências Médicas (Lisboa, Portugal)
2018 Effects of protein glycation in neurodegenerative diseases. [Invited Speaker] 3rd BioSAM – Biological Sciences Annual Meeting
Faculty of Sciences of the university of Lisbon, Portugal (Lisbon, Portugal)
2017 Sour side of sugars: Glycation in Huntington’s disease [Invited Speaker] Jornadas Lusófonas de Nutrição
Universidade Lusófona (Lisboa, Portugal)
2015/03 Glycation disrupts proteostasis and promotes neurodegenerative alterations in synucleinopathies 12th Alzheimer’s Disease and Parkinson Disease congress
Alzheimer’s Disease and Parkinson Disease (Nice, France)
2015 Adenosine A2A receptors as potential targets for Parkinson's disease-related cognitive deficits Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Ofir, Portugal)
2015 Alpha-synuclein as a blood biomarker for Parkinson’s disease [Selected Speaker] Reunião da Sociedade Portuguesa das doenças do Movimento
Sociedade Portuguesa das doenças do Movimento (Ofir, Portugal)
2014/11 Glycation disrupts proteostasis and promotes neurodegenerative alterations in synucleinopathies Society for Neurosciences (SFN)
Society for Neurosciences (SFN) (Washington, United States)
2014 AGE in yeast? New insights into the role of AGE and RAGE in health and disease EASD Symposia
(Munich, Germany)
2014 Alpha-synuclein as a blood biomarker for Parkinson’s disease [Selected Speaker] Reunião da Sociedade Portuguesa das doenças do Movimento
Sociedade Portuguesa das doenças do Movimento (Vimeiro, Portugal)
2013 Adenosine A2A receptor - A putative player in alpha-synuclein induced LTP impairment Society for Neuroscience (SFN) Annual Meeting
Society for Neuroscience (SFN) (California, United States)
2013 Heat-mediated enrichement of a-synuclein from cells and tissue for assessing post-translational modifications. [Selected Speaker] Reunião da Sociedade Portuguesa das doenças do Movimento
Sociedade Portuguesa das doenças do Movimento (Vimeiro, Portugal)
2013 Deciphering the molecular effects of alpha-synuclein post-translational modifications. [Invited Speaker] 7th Framework Programme for RTD - Grant Agreement HEALTH-2009-241791, MEFOPA
MEFOPA (Roma)
2013 Adenosine A2A receptor blockade prevents LTP impairment induced by alpha-synuclein XIII Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2010 Protein Glycation in Yeast: Novel Insights into the molecular basis of Parkinson's Disease. Lisbon Area Neuroscience Meeting
Instituto Gulbenkian Ciência (Oeiras, Portugal)
2010 The effects of glycation on alpha-synuclein misfolding and toxicity in a yeast model of Parkinson’s disease XIII Jornadas de biologia de leveduras “Nicolau van Uden”
(Lisboa, Portugal)
2009 Protein glycation and methylglyoxal metabolism in Parkinson’s disease IMM PhD students Meeting
Instituto de Medicina Molecular (Lisboa, Portugal)
2008 Protein glycation and methylglyoxal metabolism in Parkinson’s disease IMM PhD students Meeting
Instituto de Medicina Molecular (Lisboa, Portugal)
2005 Parameter estimation in multi-enzyme systems using evolutionary algorithms BKDB2005 - Bioinformatics: Knowledge Discovery in Biology
(Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/01 - 2026/12 The therapeutic role of carotid body modulation in animal models of dysmetabolism-induced neurodegeneration and of Parkinson’s disease
Supervisor
 Biomedicina (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09 - 2024/02/29 Unveiling insulin degrading enzyme as a therapeutic target for Parkinson’s disease - Luís Sousa
Supervisor
 PhD in Health Sciences (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2024 Role of IL-10 in Long-Covid - José Feliz
Supervisor
 Medicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09 - 2023/08 Therapeutic potential of anti-glycation compounds in animal models of Parkinson's disease
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/03/01 - 2022/04/01 Underlying role of glycation in the pathogenesis of Parkinson's disease - Ana Chegão - Thesis delivery in April 2022
Supervisor of Ana Chegão
 Regenerative Medicine and Mechanisms of Disease (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09 - 2022/02/25 The role of carotid body in brain insulin resistance and Neurodegeneration - Adriana Capucho - Ranked 20 out of 20!
Supervisor of Adriana Capucho
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021 Role of SNARE-dependent Gliotransmitters Release in Alzheimer's Disease: from astrocytes to circuits - Daniela Abreu - Ranked 19 out of 20!
Co-supervisor of Daniela Abreu
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021 Nanoparticle and liposome-based microreactors as reactive oxygen species scavengers in neuroinflammation 3D models - Oksana Savchak - Ranked 19 out of 20!
Co-supervisor of Oksana Savchak
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - 2021 Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signaling in Alzheimer's Disease - Tiago Coelho - Ranked 19 out of 20
Co-supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2020/08/31 Insulin Degrading Enzyme as a suppressor of alpha-synuclein pathogenesis - Ana Rita Marçal - Ranked 19 out of 20
Supervisor
 MSc in Medical Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/02 - 2020/03 Exploring the protection mechanism of insulin degrading enzyme over alpha-synuclein pathology in a cellular model of Parkinson's disease - Adriana Capucho
Supervisor
 Biomedical Research - Laboratory Rotation (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/01 - 2020/02 Impact of brain glycation in a mouse model of Parkinson's disease - Erik Cardoso
Supervisor
 Biomedical Research - Laboratory Rotation (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09 - 2019/12/09 Insulin degrading enzyme as a therapeutic target for Parkinson's disease - Mariana Guarda - Ranked 17 out of 20
Supervisor of Mariana Guarda
 Mestrado NOVA Biomedical Research (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - 2019/09/30 Impact of Insulin Degrading Enzyme on alpha-synuclein properties (solubility, toxicity, protein levels) - Yanni Schneider
Supervisor
 Molecular Medicine - International internship (Master)
Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische Fakultät, Germany
2018 - 2019/07 Sugar stress in the Brain - Bárbara Fernandes Gomes
Supervisor of Bárbara Fernandes Gomes
 Projecto de Investigação (Other)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/04 - 2019/05 Sugar stress in the Brain: targeting glycation as a novel therapeutic avenue for Parkinson's disease - Paloma Domingos
Supervisor
 Medicine - Research Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/04 - 2019/05 Glycation role in alpha-synuclein-associated Neurodegeneration: developing a mouse model to assess the neuropathological and behaviour effects of glycation - Miguel Mesquita
Supervisor
 Biomedical Research - Laboratory rotation (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/01 - 2019/04 Sugar Stress In The Brain: The Missing Link Between Diabetes and Parkinson’s Disease - Diana Chamiço
Supervisor of Diana Chamiço
 Biologia Celular e Molecular (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/04 - 2019/03/15 The effects of brain protein glycation in a mouse model of Parkinson's disease - Ana Pinto
Supervisor
 Biomedical Research - Laboratory Rotation (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018 Targeting the glycation defences as a protective strategy for Parkinson's Disease - Ana Chegão
Supervisor of Ana Chegão
 Project de Investigação (Other)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016 - 2017 Targeting the glycation defences as a protective strategy for Parkinson's Disease - Bárbara Fernandes Gomes - Scored 20 out of 20!!
Supervisor of Bárbara Fernandes Gomes
 Mestrado em Biologia molecular e celular (Master)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2013 - 2015 Alpha-synuclein as a blood biomarker for Parkinson's Disease - Rafaela Cássio - Scored 19 out of 20!
Supervisor of Rafaela Cássio
 Mestrado em Neurociências (Master)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2014 - 2014 Alpha-synuclein as a blood biomarker for Parkinson's Disease - Márcia Oliveira
Supervisor of Márcia Oliveira
 Projecto de Investigação (Other)
Instituto de Medicina Molecular, Portugal
2013 - 2014 Alpha-synuclein as a blood biomarker for Parkinson's Disease - Marcos António Gomes
Supervisor of Marcos António Gomes
 Projecto de Investigação (Other)
Instituto de Medicina Molecular, Portugal
2012 - 2013 Modulation of alpha-synuclein aggregation and toxicity - Márcia Oliveira - Scored 18 out of 20
Supervisor of Márcia Oliveira
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/09 - 2021/08 Organiser and moderator of Principal Investigators Weekly Chalk-Talks (2020/09 - 2021/08)
Seminar (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09 - 2021/08 Organiser and Moderator of Principal Investigator Monthly Meetings (2020/09 - 2021/08)
Meeting (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/02/01 - 2021/01/31 Journal Club of Neurosciences (2020/02/01 - 2021/01/31)
Seminar (President of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2016 Organizer of Pizza Seminars (2015 - 2016)
Seminar (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2015 - 2015 2nd inter-institutional post-doc retreat (2015 - 2015)
Congress (Co-organisor)
 Instituto de Medicina Molecular, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Fundação Champalimaud, Portugal
2015 - 2015 Organizer of Career Path Seminars (2015 - 2015)
Seminar (Co-organisor)
 Instituto de Medicina Molecular, Portugal
2011 - 2011 Brain awareness week: Parkinsonic Yeast (2011 - 2011)
Workshop (Co-organisor)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/03/11 - 2021/03/17 Chair/Moderator - Portuguese Congress of Diabetes - Fundamental Research
Congress
 17º Congresso de Diabetes
Sociedade Portuguesa de Diabetologia, Portugal
2020/02/13 - 2020/02/13 2º Encontro do Mestrado em Bioquímica – 2020 - Round table speaker
Round table
 Sessão V – A Bioquímica em perspetiva (Biochemistry in Perspective)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2017 Chair VI annual CEDOC PhDOC Meeting
Meeting
 VI annual CEDOC PhDOC Meeting
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2014 Chair of CAML PhD Student's meeting
Meeting
Universidade de Lisboa Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025/01 Evaluating Insulin-degrading enzyme role in the onset and development of Parkinson’s disease
Supervisor
 Soraia Chôcho (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/12 Exploring IDE as a modulator of alpha-synuclein pathology in experimental models of Parkinson’s disease
Supervisor
 Bruna Luzio (Master)
Universidade Nova de Lisboa Medical School, Portugal
2024/12 Therapeutic potential of anti-glycation compounds in animal models of Parkinson’s disease
Supervisor
 Rafaela Pina (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2024 The role of PINK1 in mitochondrial quality control and neurodegenerative diseases
(Thesis) Arguer
 Elvira Pequeno Leites (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2024 How does High-Fat diet disturb neuroregeneration: clues for the role of MIR-21 in the brain
(Thesis) Main arguer
 Bruna Martins Pires (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024 Targeting glutamine availability - a new strategy to treat malignant gliomas
(Thesis) Arguer
 Filipa Alexandra Dias Martins (PhD)
Universidade Nova de Lisboa Medical School, Portugal
2023/12 The role of insulin signalling in Alzheimer's disease
(Thesis) Main arguer
 Steven Ribeiro Alves (PhD)
Universidade de Aveiro, Portugal
2023/10 Noradrenergic Degeneration in a DJ-1 Knockout Mouse Model
(Thesis) Main arguer
 Filipa Ferreira Antunes (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022/12 Underlying role of glycation in the pathogenesis of Parkinson's disease - Ana Chegão Thesis Completed in December 2022
Supervisor
 Ana Chegão (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/11/25 THERAPEUTIC POTENTIAL OF INTRATHECAL APPLICATION OF miR-124-BASED SECRETOME IN THE SOD1G93A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS
(Thesis) Main arguer
 Marta Alexandra Marques dos Santos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/07 Studying the neuroprotective role of bone marrow-derived mesenchymal stem cell secretome using in vitro and in vivo models of Parkinson's disease
(Thesis) Main arguer
 Bárbara Pinheiro (PhD)
Laboratório Associado ICVS 3B's, Portugal

Universidade do Minho Escola de Medicina, Portugal
2022 Therapeutic potential of intrathecal application of miR-124-based secretive in the SOD1G93A model of amyotrophic lateral sclerosis
(Thesis) Main arguer
 Marta Alexandra Marques dos Santos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/12/16 The impact of the genetic risk factor BIN1 to Alzheimer’s disease development
(Thesis) Arguer
 Catarina Benavente Perdigão (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/10/07 Targeting Neuroinflammation And Neurodegeneration In Parkinson’s Disease
(Thesis) Main arguer
 Sara Oliveira (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/02/03 Insulin-Degrading enzyme as a suppressor of alpha-synuclein pathogenesis
Supervisor
 Ana Rita Miranda Marçal (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/28 Effects of glycation by methylglyoxal in saccharomyces cerevisiae
(Thesis) Main arguer
 Ana Sofia Mena Aires Pendão (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/12/09 Insulin degrading enzyme as a therapeutic target for Parkinson¿s disease - Mariana Guarda
Supervisor
 Mariana Guarda (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/11/22 Small molecule PGC-1a activators: A novel class of anti-neurodegenerative therapeutics
(Thesis) Main arguer
 Catarina Isabel Ambrósio Ranito (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/10/24 Understanding the impact of sporadic Alzheimer’s disease mutations on BIN1
(Thesis) Main arguer
 Mariana Barata (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 Dissecting the effect of Parkinson's Disease related PINK1 mutations on kinase activity.
(Thesis) Main arguer
 Filipa Alexandra Barroso Gonçalves (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 Targeting the glycation defenses as a protective strategy for Parkinson's disease
Supervisor
 Bárbara Gomes (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/07/29 Alpha-Synuclein as a blood biomarker for Parkinson¿s disease
Supervisor
 Rafaela Cássio (Master)
Instituto de Medicina Molecular, Portugal
2014 Selection of small domain antibodies specific for ß-Amyloid peptide
(Thesis) Main arguer
 Pedro Canhão (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2021/03/07 - Current European Society for Neurochemistry Member #1472
2021/03 - Current International Society for Neurochemistry Member
2021/03 - Current FENS - Federation of European Neuroscience Societies Member ESN28216
2018 - Current Sociedade Portuguesa Diabetologia Member
2018 - Current Portuguese Society for Neurosciences Member
2013 - Current Sociedade Portuguesa de Doenças do Movimento Member
2013 - Current Movement Disorders Society Member
2004 - Current Portuguese Biochemical Society Member
2014 - 2016 IMM Postdoctoral association (PDA) Elected Member of the committee

Committee member

Activity description
Role 		Institution / Organization
2020/02/01 - 2023/01/31 Elected representative of users of the cell culture Facility. Member of Decision panel of rules and strategy of cell culture facility in CEDOC, NOVA Medical School
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2016 Elected member of the direction of iMM Postdoctoral Association
Director
 Instituto de Medicina Molecular, Portugal

Conference scientific committee

Conference name Conference host
2021/06/16 - 2021/06/18 Third CEDOC Symposium on Chronic Diseases and Translational Science Nova Medical School

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02 - Current Role of Glycation in diseases - Integration of Metabolism and Nutrition Nutrição Humana e Metabolismo (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/10/21 - Current Post-translational Modifications Case Study: Neurodegenerative diseases Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09 - 2033/01 Cell and Molecular Biology Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/01 - 2023/02 Project Development in Biomedicine Biomedicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/11/28 - 2022/12/13 Cell and Molecular Mechanisms of Aging and Associated Diseases - 35h Cell and Molecular Mechanisms of Aging and Associated Diseases (Doktor (PhD)) EIT Health Ageing PhD School, Germany
2022/10/22 - 2022/10/22 Invited Lecture - Type-2 Diabetes and Parkinson's disease Doenças Metabólicas e Comportamento Alimentar (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2022/04 - 2022/04 How to evaluate neuronal loss in animal models of Neurodegeneration Biomedical Research (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/01 - 2022/02 Project Development in Biomedicine Biomedicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/01 - 2022/01 Integrative Biomedicine Biomedicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/12 - 2021/12 Invited lecture: Type 2 diabetes mellitus and its association with Parkinson’s disease and other neurodegenerative diseases Doenças Metabólicas e Comportamento Alimentar (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2021/11 - 2021/12 Cellular Regulation Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/11 - 2021/11 Critical Skills Biomedicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/10 - 2021/10 Critical Skills Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/04 - 2021/04 How to evaluate neuronal loss in animal models of Neurodegeneration Biomedical Research (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/02/20 - 2021/02/20 Role of Glycation in diseases - Integration of Metabolism and Nutrition Nutrição Humana e Metabolismo (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/01 - 2021/02 Project Development in Biomedicine PhD in Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/11 - 2020/12 Cellular Regulation Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/04/08 - 2020/04/08 How to evaluate neuronal loss in animal models of Neurodegeneration Biomedical Research (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/02/08 - 2020/02/08 Role of Glycation in diseases - Integration of Metabolism and Nutrition Nutrição Humana e Metabolismo (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/02/03 - 2020/02/07 Medicina Translacional (Translational Medicine) PhD in Mechanisms of Disease and Regenerative Medicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/11/29 - 2019/12/18 Cellular Regulation Investigação Biomédica (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/11/13 - 2019/11/13 Post-translational Modifications Case Study: Neurodegenerative diseases Bioquímica (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/04/02 - 2019/04/02 How to evaluate neuronal loss in animal models of Neurodegeneration Nova Biomedical Research MSc (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/15 - 2019/02/15 Evaluator on Translational Medicine (MSc Course) NOVA Biomedical Research MSc Course (Curso de mestrado (conclusão do curso de especialização)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/14 - 2019/02/14 Focus on Parkinson's Disease, Lecturer and Evaluator (MSc course) NOVA Biomedical Research, MSc course (Curso de mestrado (conclusão do curso de especialização)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/04 - 2019/02/08 Translational Medicine, Tutor and Evaluator (PhD course) Biomedicine PhD Course (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/04 - 2019/02/08 Medicina Translacional (Translational Medicine) PhD in Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019 Mecanismos Moleculares de Doença Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2017 Molecular Basis of Biomedicine A Base Molecular da Biomedicina Biomedicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013 - 2013 High throughput techniques for proteomic characterization CAML Ph.D. program (Doutoramento) Instituto de Medicina Molecular, Portugal
2009 - 2009 Enzymology Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2009 Bioquímica I Ciências Forenses e Criminais (Licenciatura) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2005 - 2006 Bioquímica Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2006 Enzymologia Bioquímica (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2006 Bioquímica I Ciências Farmacêuticas (Mestrado integrado) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2005 - 2005 High Performance Liquid chromatography Mass spectrometry theoretic and practical seminar to the Environmental and biological mass spectrometry group from Chemistry and Biochemistry Center from Faculdade de Ciências da Universidade de Lisboa. (Especialização pós-licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2005 Bioquímica Experimental IV Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2004 - 2005 Simulação Computacional em Bioquímica Teóricas e Práticas Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/04 - Current Project Peer Reviewer
Evaluator
 EMSTAR Pratiksha Trust, India EMSTAR Pratiksha Trust
2021 - Current Project Peer Reviewer
Evaluator
 Science Fund of the Republic of Serbia, Serbia
2021 - Current Project Peer Reviewer
Evaluator
 Fondation Recherche Alzheimer, Belgium Fondation Recherche Alzheimer
2021 - Current Project Peer Reviewer
Evaluator
 Governo dos Açores, Portugal Governo dos Açores
2021/03/18 - 2021/03/21 Research Competition Jury - Neurosciences
Evaluator
 AIMS Meeting 2021, Portugal
2021/03/11 - 2021/03/17 Oral Presentation Prize Jury
Evaluator
 Sociedade Portuguesa de Diabetologia, Portugal
2021/02/14 - 2021/03/06 Jury of Poster Sessions - International AIMS Meeting 2021
Evaluator
 AIMS Meeting 2021, Portugal
2020/03/06 - 2020/03/08 Jury of Oral presentation awards
Evaluator
 Sociedade Portuguesa de Diabetologia, Portugal
2019/03/08 - 2019/03/10 Jury of Poster awards
Evaluator
 Sociedade Portuguesa de Diabetologia, Portugal Sociedade Portuguesa de Diabetologia

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/12/06 Association between Diabetes and Parkinson's. Michael J. Fox Foundation funds NOVA Researchers A relação entre diabetes e Parkinson. Fundação Michael J. Fox financia cientistas da Nova Diário de Notícias
2022/04/25 Type-2 Diabetes patients are at higher risk of developing Parkinson's disease Pessoas com diabetes de tipo 2 são mais propensas à doença de Parkinson Público
2021/11/11 "Research project about the association between Parkinson's disease and diabetes awarded" Projecto de Investigação sobre relação entre doença de Parkinson e diabetes premiado LUSA - Clipping in several national news platforms: SIC Noticias, Visão, Observador, Notícias ao Minuto, Sapo, Postal do Algarve, Jornal Médico, O Mirante, Saúde Online, BeiraNews, Impala, JM Madeira; Mundo actual; Notícias de Coímbra; Radio Regional...
2021/07/01 How do you communicate about the use of animals in Research European Animal Research Association
2020/04/26 Title: A new relationship between diabetes and Parkinson's disease has been unveiled Portuguese scientists have been exploring the relationship between these diseases. They now bring us news about a protein that may contribute for a novel therapeutic strategy. This interview covered the latest publication about Hsp27 role in Parkinson's disease. Vicente Miranda, FASEB J, 2020 Jornal o Público
2020/04/26 "Finding another piece of the intricate relationship between diabetes and Parkinson's disease" Desvendada mais uma peça da relação intrincada entre a diabetes e a doença de Parkinson Jornal O Público
2019/04/11 Relationship between Diabetes and Parkinson's disease? Portuguese researches explain TSF radio notícias
2018/10/16 FCT does not have a deadline to present the reevaluation results of Scientific Research Projects "FCT não tem prazo para apresentar a reavaliação da candidatura dos projetos de investigação" Observador
2018/07/06 If there is more funding in Science, why are the researchers unhappy? "Se há mais dinheiro na Ciência porque é que os investigadores estão descontentes?" Observador
2018/05/23 About the unique call for FCT 2017 research projects "Sobre o concurso singular dos projetos FCT de 2017" Observador
2018/04/11 Portuguese researchers found a way to detect Parkinson's disease in a blood analysis "Portugueses descobrem como detetar Parkinson com análise ao sangue" Expresso
2017/11/27 Parkinson's disease leave scars in a protein in the blood "Doença de Parkinson deixa marcas numa proteína no sangue" Jornal O Público

Interview (tv / radio show)

Program Topic
2022/04/25 - 2022/04/25 TV News of Public Network RTP: People with Type II diabetes more likely to have Parkinson's Parkinson's Disease
2021/05/24 - 2021/05/24 The life of a scientist podcast The life of a Young PI
2021/02/18 - 2021/02/18 90 segundos de Ciência Studying the impact of Diabetes in Parkinson's disease (Estudando o impacto da Diabetes na Doença de Parkinson)
2019/04/11 - 2019/04/11 Morning news - TSF World Parkinson's disease day - Novel discoveries by DysBrainD
2017/04/11 - 2017/04/11 Diário da Manhã da TVI Interview provided by Tiago Outeiro, talking about my published work in PLOS Biology and Brain in 2017. New hope for Parkinson's disease Patients / Há uma nova esperança para os doentes de Parkinson

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current npj Parkinson's disease (2373-8057) Nature
2021 - Current JOVE - Journal of visualised experiments (1940-087X)
2020 - Current Frontiers in Cell and Developmental Biology (2296-634X) Frontiers
2020 - Current Biomolecules (2218-273X) MDPI
2020 - Current Life (2075-1729) MDPI
2020 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2017 - Current Frontiers in Neuroscience (1662-453X) Frontiers
2017 - Current Canadian Journal of Physiology and Pharmacology (0008-4212) Canadian Science Publishing

Mentoring / Tutoring

Topic Student name
2012 - 2014 Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntingtons’s disease Leonor Fleming
2012 - 2014 The role of alpha-synuclein phosphorylation in synucleinopathies Elisa Basso

Other jury / evaluation

Activity description Institution / Organization
2019/03/01 - Current PhD Thesis Committee - Tatiana Burrinha - Lysosomes dysfunction, the link between Aging and Alzheimer ´s disease? Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/01 - Current PhD Thesis Committee - Diego Borges - New insights in insulin clearance Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2025 PhD Thesis Committee - Mariana Afonso Barata - Breaking BIN1: Investigating mechanisms of synaptic dysfunction in Alzheimer’s disease Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2024 PhD Thesis Committee - Bernardo Antunes - The Metabolic Profile of Brain Mitochondria Instituto de Medicina Molecular, Portugal
2020 - 2024 PhD Thesis Committee - André Gabriel - Unraveling the functional interactions between circular RNAs and RNA binding proteins in atrial fibrillation Instituto de Medicina Molecular, Portugal
2018 - 2022 PhD Thesis Committee - Filipa Gonçalves - Parkinson’s Disease and Mitochondrial dysfunction: the role of PINK1 in mitochondria maintenance and clearance Instituto de Medicina Molecular, Portugal
2019/03/08 - 2019/03/10 Jury of Poster prize of Congresso da Sociedade Portuguesa de Diabetologia Sociedade Portuguesa de Diabetologia, Portugal
2018 - 2018 Jury of PhD Thesis Committee - Sara Oliveira Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2018 Jury of Poster Prize CEDOC PhD students retreat Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2018 Jury of Poster Prize - CEDOC PhDOC Meeting Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2018 PhD Thesis Committee - Joana Branco dos Santos Instituto de Medicina Molecular, Portugal
Distinctions

Award

2024 Award for Best Neuroscience and Diabetology Project - Bolsa José Luís Medina
Sociedade Portuguesa de Diabetologia, Portugal
2023 Award for Best Paper in Diabetology
Sociedade Portuguesa de Diabetologia, Portugal
2021 Big Prize from Portuguese Diabetology Society
Sociedade Portuguesa de Diabetologia, Portugal
2014 Award for best Poster at 8th EHDN Plenary meeting (Barcelona)
European Huntington's Disease Network (EHDN), Spain
2009 Award for best oral presentation
Instituto de Medicina Molecular, Portugal

Other distinction

2021 Research Grant: IDE as a biomarker. Vicente Miranda (PI) EUR 5.000,00
Sociedade Portuguesa de Diabetologia, Portugal
2021 Research Grant: Preventing the development of Parkinson's disease in Type-2 diabetes Patients. Vicente Miranda (PI) EUR 20.000,00
Sociedade Portuguesa de Diabetologia, Portugal
2021 Cover of Journal of Pathology Dec 2021
The Journal of Pathology, United Kingdom
2019 Junior Researcher [Awardee EUR 228.000,00]
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 Research Grant Sweet_PD_Multi/04462. Vicente Miranda (PI) EUR 70.000,00
iNOVA4Health, Portugal
2018 Research Grant: Stress dos Açucares no Cérebro. Vicente Miranda (PI) EUR 5.000,00
Sociedade Portuguesa de Diabetologia, Portugal
2017 HIGHLIGHT in Nature Reviews Molecular Cell Biology of "The mechanism of Sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson's disease", published in PLoS Biology
Nature Reviews Molecular Cell Biology, United Kingdom
2016 Research Grant PTDC/NEU-OSD/5644/2014. Vicente Miranda (PI) EUR 199.961,00
Fundação para a Ciência e a Tecnologia, Portugal
2015 Post-doctoral Research Fellowship [Awardee EUR 118.000,00]
Fundação para a Ciência e a Tecnologia, Portugal
2013 Research Grant: EXPL/NEU-OSD/0606/2012. Vicente Miranda (PI) (EUR 50.000,00)
Fundação para a Ciência e a Tecnologia, Portugal
2012 Post-doctoral Research Fellowship [Awardee EUR 21.500,00]
European Commission Seventh Framework Programme for Research and Technological Development, Belgium
2010 Post-doctoral Research Fellowship [Awardee EUR 115.000,00]
Fundação para a Ciência e a Tecnologia, Portugal
2006 PhD Fellowship [Awardee EUR 115.000,00]
Fundação para a Ciência e a Tecnologia, Portugal