???global.info.a_carregar???
Identification

Personal identification

Full name
José Maria Ferreira La Fuente de Carvalho La Fuente de Carvalho

Citation names

  • Carvalho, José

Author identifiers

Ciência ID
2717-8E70-3E25
ORCID iD
0000-0001-5605-8461
Education
Degree Classification
2013/03/16
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Instituto de Ciências Biomedicas Abel Salazar
Universidade do Porto, Portugal
 Aprovado
2013/03/16
Concluded
 Instituto de Ciencias Biomedicas Abel Salazar (Título de Agregado)
Major in Grau Academico
Universidade do Porto, Portugal
 Aprovado
2003
Concluded
 PhD in medical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1973 - 1979
Concluded
 Medicine degree (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
Affiliation

Science

Category
Host institution 		Employer
2003 - Current Researcher (Research) Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2003 - Current Invited Full Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Others

Category
Host institution 		Employer
2007 - Current Head of Service (Urology) Centro Hospitalar Universitário do Porto EPE, Portugal
Projects

Other

Designation Funders
2020/02 - Current Avaliação da disfunção eréctil como marcador de disfunção vascular em micro-artérias de doentes com obesidade e resistência à insulina
DEFI - CHUP
Researcher
Ongoing
2012 - 2012 Influência do envellhecimento vascular na vasodilatação endotelial das artérias mesentéricas humanas
DEFI - CHUP
Researcher
Concluded
2012 - 2012 Estimulación de vías de señalización que activan la eNOS como estrategia terapéutica para mejorar la eficacia de los inhibidores PDE5 en el tejido eréctil humano”
DEFI : CHUP
Researcher
Ongoing
2011 - 2012 Implicações clínicas da relação entre a obesidade e o carcinoma da prostata através do estudo de adipocinas inflamatórias e a biopsia da prostata transretal.
313/11 (210-DEFI/299-CES)
Researcher
Concluded
2011 - 2011 Tadalafil potentiates NO0/cGMP pathway in human prostate and enhances the efficacy of a1-adrenergic receptor antagonist, tamsoluzin, in inhibiting contractions of human prostate and bladder neck
DEFI - CHUP
Researcher
2011 - 2011 Avaliação do stress oxidativo no soro de doentes diabéticos com disfunção eréctil
312/11 (209-DEFI/298-CES)
Researcher
Concluded
2010 - 2010 Avaliação dos efeitos de nebivolol no relaxamento e acumulação de GMPc induzido pelos inibidores de sildenafil, tadalafil e vardenafil no corpo cavernoso humano e artérias de resistência de doentes diabéticos 081/10 (059-DEFI/077-CES)
081/10 (059-DEFI/077-CES)
Researcher
Concluded
2009 - 2009 Estudo multinacional aleatorizado, duplamente cego, controlado por placebo, de braços paralelos, destinado a avaliar a eficácia e segurança de tadalafil 2,5 e 5 mg, uma vez ao dia durante 12 semanas para tratamento da disfunção eréctil e dos sintomas de hiperplasia benigna da prostata em homens com
006/09 (NA-DEFI / 062-CES)
Technical development
Concluded
2009 - 2009 Modulação e remodulação dos vasos cavernosos humanos por purinas – importância da fisiopatologia da disfunção eréctil associada a diabetes mellitus 2
Projecto FCT –
Researcher
2007 - 2007 – Prevalência e indicadores de disfunção sexual masculina em doentes diabéticos 003/07 (DEFI-CES)
003/07 (DEFI-CES)
Researcher
Concluded
2007 - 2007 – “A placebo-controlled, double-blind, randomized, parallel group study of the efficacy and safety of dapoxetine in the treatment of subjects with premature ejaculation” 018/05 (DEFI-CES
018/05 (DEFI-CES
Researcher
Concluded
2005 - 2007 – Modulação purinérgica do tecido cavernoso em homens com e sem disfunção eréctil 011/05 (DEFI-CES)
011/05 (DEFI-CES)
Researcher
2005 - 2005 Avaliação de diferentes abridores de canais de potássio sobre a contractilidade da bexiga humana 009/05 (DEFI-CES)
009/05 (DEFI-CES)
Researcher
2005 - 2005 Avaliação de outras fosfodiesterases disntintas do tipo 5 como novo-alvo terapêutico para o desenvolvimento de novos tratamentos da disfunção eréctil 010/05 (DEFI-CES)
010/05 (DEFI-CES)
Researcher
Outputs

Publications

Book
  1. Carvalho, José. Peniopatia Diabetica. Matosinhos, Portugal: La Fuente de Carvalho. 2019.
    Published
  2. Carvalho, José. Actualizações na Infertilidade. 2010.
    Published
  3. Carvalho, José. O Homem aos 60 anos. Matosinhos, Portugal: La Fuente de Carvalho. 2008.
    Published
Book chapter
  1. Carvalho, José. "Disfunção Sexual em Oncologia". In Manual do Interno - Grupo Português de Oncologia Urológica. Porto, Portugal, 2019.
    Published
  2. Carvalho, José. "Fisiologia dos Genitais Masculinos". In Fisiologia Clinica. Porto, Portugal, 2017.
    Published
  3. Carvalho, José. "Clinical evaluation of erectile dysfunction". In International Book of Erectile Dysfunction. New York, United States, 2016.
  4. Carvalho, José. "Neoplasia do Pénis". In Grupo Português de Oncologia Génito Urinária e Sociedade Portuguesa de Oncologia. 2016.
    Published
  5. Carvalho, José. "A Andrologia no séc. XXI". In Instituto Hellis. S Paulo, Brazil, 2008.
  6. Carvalho, José. "Disfunção eréctil - Abordagem clinica". In Consensos na Disfunção Eréctil. Lisboa, Portugal, 2006.
  7. Carvalho, José. "Hiperplasia benigna da próstata – Recomendações terapêuticas". In Recomendações terapêuticas, 173-187. Lisboa, Portugal: Acta Médica Portuguesa, c, Vol. 14, Nº 2 (173-187), 2001, 2001.
    Published
  8. Carvalho, José. "Anatomia do Pénis". In Andrologia Clinica - Sociedade Portuguesa de Andrologia. 2000.
    Published
  9. Carvalho, José. "Fisiologia da erecção". In Andrologia Clinica - Sociedade Portuguesa de Andrologia. Lisboa, Portugal, 2000.
    Published
Journal article
  1. Alejandro Sevilleja-Ortiz; Mariam El Assar; Esther García-Rojo; Borja García-Gómez; Argentina Fernández; Alberto Sánchez-Ferrer; José M. La Fuente; et al. "Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue". Mechanisms of Ageing and Development 200 (2021): 111590-111590. https://doi.org/10.1016/j.mad.2021.111590.
    10.1016/j.mad.2021.111590
  2. Sevilleja-Ortiz, Alejandro; El Assar, Mariam; García-Rojo, Esther; Romero-Otero, Javier; García-Gómez, Borja; Fernández, Argentina; Medina-Polo, José; et al. "Enhanced Contribution of Orai Channels to Contractility of Human Penile Smooth Muscle in Erectile Dysfunction". The Journal of Sexual Medicine 17 5 (2020): 881-891. http://dx.doi.org/10.1016/j.jsxm.2020.02.020.
    Open access • Published • 10.1016/j.jsxm.2020.02.020
  3. La Fuente, José M.; Fernández, Argentina; Pepe-Cardoso, Augusto J.; Martínez-Salamanca, Juan I.; Louro, Nuno; Angulo, Javier. "L-cysteine/hydrogen sulfide pathway induces cGMP-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by PDE5 inhibition". European Journal of Pharmacology 863 (2019): 172675. http://dx.doi.org/10.1016/j.ejphar.2019.172675.
    10.1016/j.ejphar.2019.172675
  4. Duarte, M.F.; Luis, C.; Baylina, P.; Faria, M.I.; Fernandes, R.; La Fuente, J.M.. "Clinical and metabolic implications of obesity in prostate cancer: is testosterone a missing link?". Aging Male 22 4 (2019): 228-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055578655&partnerID=MN8TOARS.
    10.1080/13685538.2018.1519695
  5. Angulo, J.; El Assar, M.; Sevilleja-Ortiz, A.; Fernández, A.; Sánchez-Ferrer, A.; Romero-Otero, J.; Martínez-Salamanca, J.I.; La Fuente, J.M.; Rodríguez-Mañas, L.. "Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention". Redox Biology 26 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068573167&partnerID=MN8TOARS.
    10.1016/j.redox.2019.101271
  6. Adubeiro, N.; Nogueira, M.L.; Nunes, R.G.; Ferreira, H.A.; Ribeiro, E.; La Fuente, J.M.F.. "Apparent diffusion coefficient in the analysis of prostate cancer: determination of optimal b-value pair to differentiate normal from malignant tissue". Clinical Imaging 47 (2018): 90-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029297141&partnerID=MN8TOARS.
    10.1016/j.clinimag.2017.09.004
  7. Lopes-Santos, J.A.; Martins, C.; La Fuente, J.M.; Costa-Carvalho, M.F.. "A novel approach for classifying protruding ears is easy to calculate and implement in daily clinical practice". Acta Paediatrica, International Journal of Paediatrics 106 9 (2017): 1525-1530. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019357458&partnerID=MN8TOARS.
    10.1111/apa.13870
  8. Martínez-Salamanca, Juan I.; La Fuente, José M.; Martínez-Salamanca, Eduardo; Fernández, Argentina; Pepe-Cardoso, Augusto J.; Louro, Nuno; Carballido, Joaquín; Angulo, Javier. "a 1A -Adrenergic Receptor Antagonism Improves Erectile and Cavernosal Responses in Rats With Cavernous Nerve Injury and Enhances Neurogenic Responses in Human Corpus Cavernosum From Patients With Erectile Dysfunction Secondary to Radical Prostatectomy". The Journal of Sexual Medicine 13 12 (2016): 1844-1857. http://dx.doi.org/10.1016/j.jsxm.2016.10.005.
    10.1016/j.jsxm.2016.10.005
  9. Martínez-Salamanca, J.I.; La Fuente, J.M.; Fernández, A.; Martínez-Salamanca, E.; Pepe-Cardoso, A.J.; Carballido, J.; Angulo, J.. "Nitrergic function is lost but endothelial function is preserved in the corpus cavernosum and penile resistance arteries of men after radical prostatectomy". Journal of Sexual Medicine 12 3 (2015): 590-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924074033&partnerID=MN8TOARS.
    10.1111/jsm.12801
  10. Martínez-Salamanca, J.I.; La Fuente, J.M.; Cardoso, J.; Fernández, A.; Cuevas, P.; Wright, H.M.; Angulo, J.. "Nebivolol potentiates the efficacy of PDE5 inhibitors to relax corpus cavernosum and penile arteries from diabetic patients by enhancing the NO/cGMP pathway". Journal of Sexual Medicine 11 5 (2014): 1182-1192. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899483063&partnerID=MN8TOARS.
    10.1111/jsm.12477
  11. La Fuente, J.M.; Fernández, A.; Cuevas, P.; González-Corrochano, R.; Chen, M.X.; Angulo, J.. "Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats". European Journal of Pharmacology 735 1 (2014): 68-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899664310&partnerID=MN8TOARS.
    10.1016/j.ejphar.2014.03.060
  12. González-Corrochano, R.; La Fuente, J.M.; Cuevas, P.; Fernández, A.; Chen, M.X.; Angulo, J.. "Ca 2+-activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction". British Journal of Pharmacology 169 2 (2013): 449-461. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876947729&partnerID=MN8TOARS.
    10.1111/bph.12143
  13. Angulo J; Cuevas P; Fernández A; La Fuente JM; Allona A; Moncada I; Sáenz de Tejada I. "Tadalafil enhances the inhibitory effects of tamsulosin on neurogenic contractions of human prostate and bladder neck.". (2012): http://europepmc.org/abstract/med/22759598.
    10.1111/j.1743-6109.2012.02821.x
  14. Angulo J; Wright HM; Cuevas P; González-Corrochano R; Fernández A; Cuevas B; La Fuente JM; Gupta S; Sáenz de Tejada I. "Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling.". (2010): http://europepmc.org/abstract/med/20214719.
    10.1111/j.1743-6109.2010.01710.x
  15. Angulo J; González-Corrochano R; Cuevas P; Fernández A; La Fuente JM; Rolo F; Allona A; Sáenz de Tejada I. "Diabetes exacerbates the functional deficiency of NO/cGMP pathway associated with erectile dysfunction in human corpus cavernosum and penile arteries.". (2010): http://europepmc.org/abstract/med/19912487.
    10.1111/j.1743-6109.2009.01587.x
  16. Angulo J; Peiró C; Cuevas P; Gabancho S; Fernández A; González-Corrochano R; La Fuente JM; et al. "The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men.". (2009): http://europepmc.org/abstract/med/19040617.
    10.1111/j.1743-6109.2008.01088.x
  17. Hugo Nogueira, V.; Vila, F.; Osório, L.; Cavadas, V.; Teves, F.; Sabel, F.; Oliveira, M.; et al. "Spermatic cord torsion: diagnostic and therapeutic aspects | Torção do cordão espermático: aspectos de diagnóstico e terapêutica". Revista Internacional de Andrologia 7 1 (2009): 28-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-62249126166&partnerID=MN8TOARS.
    10.1016/S1698-031X(09)70259-6
  18. Carvalho, José. "Decreased Ecto-Ntpdase1/Cd39 Activity Leads to Desensitization of P2 Purinoceptors Regulating Tonus of Corpora Cavernosa in Impotent Men with Endothelial Dysfunction". Nucleosides, nucleotides and nucleic acids,27:6, 761-768 (2008):
    10.1080/15257770802145744.
  19. Angulo J; Cuevas P; Fernández A; Allona A; Moncada I; Martín-Morales A; La Fuente JM; de Tejada IS. "Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity.". (2006): http://europepmc.org/abstract/med/16888082.
    10.1124/jpet.106.108597
  20. Faria, M.; Magalhães-Cardoso, T.; Lafuente-De-Carvalho, J.-M.; Correia-De-Sá, P.. "Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A2B receptor dysfunction". Journal of Pharmacology and Experimental Therapeutics 319 1 (2006): 405-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749035754&partnerID=MN8TOARS.
    10.1124/jpet.106.107821
  21. Borges, R.; Versos, R.; Louro, N.; Massó, P.; Vila, F.; Osório, L.; Cavadas, V.; et al. "Male pseudohermaphroditism. Gender redistribution due to 17 ß-hydroxysteroid dehydrogenase deficiency | Pseudohermafroditismo masculino. Reatribuição de género por deficiência de 17 ß-hidroxiesteroide dehidrogenase". Revista Internacional de Andrologia 4 1 (2006): 39-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547898767&partnerID=MN8TOARS.
    10.1016/S1698-031X(06)73566-X
  22. Angulo J; Cuevas P; La Fuente JM; Pomerol JM; Ruiz-Castañé E; Puigvert A; Gabancho S; et al. "Regulation of human penile smooth muscle tone by prostanoid receptors.". (2002): http://europepmc.org/abstract/med/11976264.
    10.1038/sj.bjp.0704675
  23. Angulo, J.; Cuevas, P.; La Fuente, J.M.; Pomerol, J.M.; Ruiz-Castañé, E.; Puigvert, A.; Gabancho, S.; et al. "Regulation of human penile smooth muscle tone by prostanoid receptors". British Journal of Pharmacology 136 1 (2002): 23-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036261241&partnerID=MN8TOARS.