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Identification

Personal identification

Full name
Ana Isabel Dias Neto Domingos

Citation names

  • Domingos, Ana I

Author identifiers

Ciência ID
251E-E75B-E8AC
ORCID iD
0000-0002-7938-4814

Websites

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2000/11/01 - 2005/05/01
Concluded
 PhD Leslie Vosshall laboratory (Doktor (PhD))
The Rockefeller University, United States
1995/09/01 - 1999/06/01
Concluded
 Matemática (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2018/09/01 - Current Coordinating Researcher (Research) University of Oxford Department of Physiology Anatomy and Genetics, United Kingdom
University of Oxford Department of Physiology Anatomy and Genetics, United Kingdom
2013/10/01 - Current Auxiliary Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
2006/03/01 - 2013/09/30 Postdoc (Research) The Rockefeller University, United States
Projects

Grant

Designation Funders
2019/01 - 2024/12 Sympathetic and immune mechanisms underlying Obesity
ERC-2017-COG 771431
Principal investigator
European Research Council, Belgium
 European Research Council
Ongoing
2017/09 - 2022/09 HHMI / Welcome International Research Scholar Award
208576/Z/17/Z
 Wellcome Trust
2016/05 - 2019/04 Neuroanatomy of fat discerned with whole body optoacoustic and fluorescence imaging
e1698963
 International Human Frontier Science Program Organization
2015/07 - 2018/06 Optogenetic dissection of neural circuits controlling adiposity
Provided by PTCRIS: 142379
 Fundação para a Ciência e a Tecnologia
2015/07 - 2018/06 Optogenetic dissection of neural circuits controlling adiposity
grant.Provided by PTCRIS: 142379
 Fundação para a Ciência e a Tecnologia
2013/07 - 2015/06 Molecular profiling of AGRP neurons and hyperphagia
Provided by PTCRIS: 126812
 Fundação para a Ciência e a Tecnologia
2013/07 - 2015/06 Molecular profiling of AGRP neurons and hyperphagia
grant.Provided by PTCRIS: 126812
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. "Distress, brain metabolism, and inflammatory processes: A study with metastatic breast cancer patients". 2018.
    10.1002/pon.4878
Conference paper
  1. Voss, H.U.; Domingos, A.I.. "Analysis of coexisting neuronal populations in optogenetic and conventional BOLD data". 2012.
    10.1109/SPMB.2012.6469467
  2. Voss, H.U.; Ballon, D.J.; Domingos, A.I.. "Neuronal and hemodynamic source modeling of optogenetic BOLD signals". 2011.
    10.1109/SPMB.2011.6120104
Journal article
  1. Cardoso F; Klein Wolterink RGJ; Godinho-Silva C; Domingues RG; Ribeiro H; da Silva JA; Mahú I; Domingos AI; Veiga-Fernandes H. "Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit.". Nature (2021): http://europepmc.org/abstract/med/34408322.
    10.1038/s41586-021-03830-7
  2. O'Brien CJO; Domingos AI. "An anti-obesity immunotherapy?". Science (New York, N.Y.) (2021): http://europepmc.org/abstract/med/34210864.
    10.1126/science.abj5072
  3. Larabee, C.M.; Neely, O.C.; Domingos, A.I.. "Obesity: a neuroimmunometabolic perspective". Nature Reviews Endocrinology 16 1 (2020): 30-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075687331&partnerID=MN8TOARS.
    10.1038/s41574-019-0283-6
  4. Domingos, A.I.. "Leptin: a missing piece in the immunometabolism puzzle". Nature Reviews Immunology 20 1 (2020): 3-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075527839&partnerID=MN8TOARS.
    10.1038/s41577-019-0251-3
  5. Badenes, M.; Amin, A.; González-García, I.; Félix, I.; Burbridge, E.; Cavadas, M.; Ortega, F.J.; et al. "Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis". Molecular Metabolism 31 (2020): 67-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075953290&partnerID=MN8TOARS.
    10.1016/j.molmet.2019.10.006
  6. Sarker, G.; Larabee, C.M.; Domingos, A.I.. "ILC3s gut rhythm". Nature Immunology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077469634&partnerID=MN8TOARS.
    10.1038/s41590-019-0580-1
  7. Mahú, I.; Barateiro, A.; Rial-Pensado, E.; Martinéz-Sánchez, N.; Vaz, S.H.; Cal, P.M.S.D.; Jenkins, B.; et al. "Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects". Cell Metabolism (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085312788&partnerID=MN8TOARS.
    10.1016/j.cmet.2020.04.013
  8. Haberman, E.R.; Domingos, A.I.. "Illuminating Neuroimmunity: A Humoral Brain". Immunity 52 6 (2020): 900-902. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086498811&partnerID=MN8TOARS.
    10.1016/j.immuni.2020.05.011
  9. Seoane-Collazo, P.; Liñares-Pose, L.; Rial-Pensado, E.; Romero-Picó, A.; Moreno-Navarrete, J.M.; Martínez-Sánchez, N.; Garrido-Gil, P.; et al. "Central nicotine induces browning through hypothalamic ¿ opioid receptor". Nature Communications 10 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071896682&partnerID=MN8TOARS.
    10.1038/s41467-019-12004-z
  10. Blankenhaus, B.; Braza, F.; Martins, R.; Bastos-Amador, P.; González-García, I.; Carlos, A.R.; Mahu, I.; et al. "Ferritin regulates organismal energy balance and thermogenesis". Molecular Metabolism 24 (2019): 64-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063740016&partnerID=MN8TOARS.
    10.1016/j.molmet.2019.03.008
  11. Berger, J.M.; Singh, P.; Khrimian, L.; Morgan, D.A.; Chowdhury, S.; Arteaga-Solis, E.; Horvath, T.L.; et al. "Mediation of the Acute Stress Response by the Skeleton". Cell Metabolism 30 5 (2019): 890-902.e8. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073686107&partnerID=MN8TOARS.
    10.1016/j.cmet.2019.08.012
  12. Pirzgalska, R.M.; Domingos, A.I.. "Macrophages in obesity". Cellular immunology 330 (2018): 183-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051648735&partnerID=MN8TOARS.
    10.1016/j.cellimm.2018.04.014
  13. Schneeberger, M.; Tan, K.; Nectow, A.R.; Parolari, L.; Caglar, C.; Azevedo, E.; Li, Z.; Domingos, A.; Friedman, J.M.. "Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons". Molecular Metabolism 13 (2018): 83-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047483129&partnerID=MN8TOARS.
    10.1016/j.molmet.2018.05.001
  14. Zufall, F.; Domingos, A.I.. "The structure of Orco and its impact on our understanding of olfaction". Journal of General Physiology 150 12 (2018): 1602-1605. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057770867&partnerID=MN8TOARS.
    10.1085/jgp.201812226
  15. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193)". Nature 562 7725 (2018): 150-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054338940&partnerID=MN8TOARS.
    10.1038/s41586-018-0311-z
  16. "Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine". Nature Medicine (2017): http://dx.doi.org/10.1038/nm.4422.
    10.1038/nm.4422
  17. Pereira, M.M.A.; Mahú, I.; Seixas, E.; Martinéz-Sánchez, N.; Kubasova, N.; Pirzgalska, R.M.; Cohen, P.; et al. "Corrigendum: A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages". Nature communications 8 (2017): 15673-15673. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056394541&partnerID=MN8TOARS.
    10.1038/ncomms15673
  18. Mahú, I.; Domingos, A.I.. "The sympathetic neuro-adipose connection and the control of body weight". Experimental Cell Research (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016042784&partnerID=MN8TOARS.
    10.1016/j.yexcr.2017.03.047
  19. Barateiro, A.; Mahú, I.; Domingos, A.I.. "Leptin resistance and the neuro-adipose connection". Frontiers in Endocrinology 8 MAR (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017107612&partnerID=MN8TOARS.
    10.3389/fendo.2017.00045
  20. Pereira, M.M.A.; Mahú, I.; Seixas, E.; Martinéz-Sánchez, N.; Kubasova, N.; Pirzgalska, R.M.; Cohen, P.; et al. "A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages". Nature Communications 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017004495&partnerID=MN8TOARS.
    10.1038/ncomms14967
  21. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions". Nature 533 7601 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84966364917&partnerID=MN8TOARS.
    10.1038/nature16968
  22. Sano, T.; Huang, W.; Hall, J.A.; Yang, Y.; Chen, A.; Gavzy, S.J.; Lee, J.-Y.; et al. "Erratum: An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses (Cell (2015) 163 (381-393))". Cell 164 1-2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954289194&partnerID=MN8TOARS.
    10.1016/j.cell.2015.12.047
  23. Reis, B.S.; Lee, K.; Fanok, M.H.; Mascaraque, C.; Amoury, M.; Cohn, L.B.; Rogoz, A.; et al. "Leptin receptor signaling in T cells is required for Th17 differentiation". Journal of Immunology 194 11 (2015): 5253-5260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929649679&partnerID=MN8TOARS.
    10.4049/jimmunol.1402996
  24. Sano, T.; Huang, W.; Hall, J.A.; Yang, Y.; Chen, A.; Gavzy, S.J.; Lee, J.-Y.; et al. "An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses". Cell 163 2 (2015): 381-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943638660&partnerID=MN8TOARS.
    10.1016/j.cell.2015.08.061
  25. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions". Nature 528 7583 (2015): 517-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951288125&partnerID=MN8TOARS.
    10.1038/nature16193
  26. Zeng, W.; Pirzgalska, R.M.; Pereira, M.M.A.; Kubasova, N.; Barateiro, A.; Seixas, E.; Lu, Y.-H.; et al. "Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis". Cell 163 1 (2015): 84-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944733460&partnerID=MN8TOARS.
    10.1016/j.cell.2015.08.055
  27. Kubasova, N.; Burdakov, D.; Domingos, A.I.. "Sweet and low on leptin: Hormonal regulation of sweet taste buds". Diabetes 64 11 (2015): 3651-3652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956851300&partnerID=MN8TOARS.
    10.2337/dbi15-0004
  28. "Cellular and molecular basis of decision-making". EMBO reports (2014): http://dx.doi.org/10.15252/embr.201438993.
    10.15252/embr.201438993
  29. Domingos, A.I.; Vaynshteyn, J.; Sordillo, A.; Friedman, J.M.. "The reward value of sucrose in leptin-deficient obese mice". Molecular Metabolism 3 1 (2014): 73-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895141804&partnerID=MN8TOARS.
    10.1016/j.molmet.2013.10.007
  30. Domingos, A.I.; Sordillo, A.; Dietrich, M.O.; Liu, Z.-W.; Tellez, L.A.; Vaynshteyn, J.; Ferreira, J.G.; et al. "Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar". eLife 2013 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891822239&partnerID=MN8TOARS.
    10.7554/eLife.01462
  31. "Lean on Leptin or Lean for Sugar". Journal of Obesity & Weight Loss Therapy (2013): http://dx.doi.org/10.4172/2165-7904.1000166.
    10.4172/2165-7904.1000166
  32. Stanley, S.; Domingos, A.I.; Kelly, L.; Garfield, A.; Damanpour, S.; Heisler, L.; Friedman, J.. "Profiling of glucose-sensing neurons reveals that ghrh neurons are activated by hypoglycemia". Cell Metabolism 18 4 (2013): 596-607. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885145339&partnerID=MN8TOARS.
    10.1016/j.cmet.2013.09.002
  33. Chaudhury, D.; Walsh, J.J.; Friedman, A.K.; Juarez, B.; Ku, S.M.; Koo, J.W.; Ferguson, D.; et al. "Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons". Nature 493 7433 (2013): 532-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872925363&partnerID=MN8TOARS.
    10.1038/nature11713
  34. Domingos, A.I.; Vaynshteyn, J.; Voss, H.U.; Ren, X.; Gradinaru, V.; Zang, F.; Deisseroth, K.; De Araujo, I.E.; Friedman, J.. "Leptin regulates the reward value of nutrient". Nature Neuroscience 14 12 (2011): 1562-1568. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255186756&partnerID=MN8TOARS.
    10.1038/nn.2977
  35. Fishilevich, E.; Domingos, A.I.; Asahina, K.; Naef, F.; Vosshall, L.B.; Louis, M.. "Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila". Current Biology 15 23 (2005): 2086-2096. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444462215&partnerID=MN8TOARS.
    10.1016/j.cub.2005.11.016
  36. Larsson, M.C.; Domingos, A.I.; Jones, W.D.; Chiappe, M.E.; Amrein, H.; Vosshall, L.B.. "Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction". Neuron 43 5 (2004): 703-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444222660&partnerID=MN8TOARS.
    10.1016/j.neuron.2004.08.019
Preprint
  1. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.7554/eLife.91318.1.
    10.7554/eLife.91318.1
  2. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.7554/eLife.91318.
    10.7554/eLife.91318
  3. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.1101/2023.09.26.559578.
    10.1101/2023.09.26.559578
Activities

Association member

Society Organization name Role
2022/07/01 - Current American Physiological Society Editor in Chief (AJP- Endocrinology and Metabolism) - https://journals.physiology.org/ajpendo/edboard

Committee member

Activity description
Role 		Institution / Organization
2020/09/09 - Current Member of the Advisory Board (Cell Metabolism)
Other
 Cell Press, United States
2019/01/01 - Current Member of Board of Reviewing Editors (eLife)
Other
 eLife Sciences Publications Ltd, United Kingdom