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I’m graduated in Biomedical Sciences, more precisely in Anatomia Patológica, Citológica e Tanatológica, where I had acquired all knowledge related to histology, immunohistochemistry, necropsy and tissue processing. My first professional experience started in January 2009 as a lab manager at Rheumatology Research Unit, Instituto de Medicina Molecular. The main responsibilities were financial management of projects as well as management and organization of the laboratory work and material. At the same time I started to work at Rheumatology Service at Hospital Santa Maria as a Study Coordinator of clinical trials in rheumatoid arthritis, osteoporosis and lupus. Moreover, In 2010 I have attended to the intensive course of Animal manipulation FELASA Cat B. Over the last 10 years, I have worked with several animal models, used all the available routes for drug delivery, developed immunization techniques for arthritis induction and oophorectomy procedure for osteoporotic studies. April 2017, I have concluded my PhD in Biomedical Sciences in Rheumatology field (started in 2012), with a work entitled “How early inflammatory events affect bone nano properties at rheumatoid arthritis onset”. Over 11 years of award-winning research I have developed several studies related to inflammation and rheumatology field, I have also conducted several pre-clinical studies in order to investigate the efficacy, toxicity and bone effects of 10 compounds (5 from global pharmaceutical companies). During this period 16 research articles were published. During my PhD I have performed several scientific formations techniques related to microarchitecture, biomechanics and material composition, such as micro computed tomography (micro-CT) (Oulu University, Finland), histomorphometry (INSERM, France), flexural tests (3-point bending) ( Instituto Superior Técnico de Lisboa), nanoindentation (Cranfield University, UK), X-ray spectroscopy (Instituto de ciências de saúde do sul) and fourier transform infrared spectroscopy (ftir) (Oulu University, Finland).
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Identification

Personal identification

Full name
Bruno Miguel Costa Vidal

Citation names

  • Vidal, Bruno

Author identifiers

Ciência ID
251C-3CD5-FB69
ORCID iD
0000-0003-2906-4705

Email addresses

  • vidal.bmc@gmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Engineering and Technology - Medical Engineering - Medical Engineering
  • Medical and Health Sciences - Health Sciences - Social Biomedical Sciences
  • Medical and Health Sciences - Clinical Medicine - Rheumatology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2017/04/19
Concluded
 Biomedical Sciences - Biopathological Sciences (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
""How early inflammatory events affect bone nano properties at rheumatoid arthritis onset"" (THESIS/DISSERTATION)
 "Aprovado com distinção e louvor por unanimidade"
2017/04/17
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Ciências Biopatológicas
Universidade de Lisboa Faculdade de Medicina, Portugal
"How early inflammatory events affect bone nano properties at rheumatoid arthritis onset" (THESIS/DISSERTATION)
2011/04/13
Concluded
 "Laboratory Animal Science" (Curso de Especialização Tecnológica)
Instituto de Medicina Molecular, Portugal
"n/a" (THESIS/DISSERTATION)
 18 valores
2008/08/01
Concluded
 Anatomia Patológica Citológica e Tanatológica (Licenciatura)
Escola Superior de Saúde Egas Moniz, Portugal
"Técnico de Anatomia Patológica Citológica e Tanatológica" (THESIS/DISSERTATION)
 15
Affiliation

Others

Category
Host institution 		Employer
2017/08/01 - Current Postdoctoral Researcher Instituto de Medicina Molecular, Portugal
2016/01/02 - 2017/05/31 European Calcified Tissue Society/ Amgen Fellowship Universidade de Lisboa Faculdade de Medicina, Portugal
2009/09/01 - 2017/05/01 Monitor de aulas de histologia prática de Engenharia Biomédica Universidade de Lisboa Faculdade de Medicina, Portugal
2012/01/02 - 2017/04/19 PhD Student - How early inflammatory events affect bone nano properties at rheumatoid arthritis onset - SFRH / BD / 81527 / 2011 (FCT Fellowship). Universidade de Lisboa Faculdade de Medicina, Portugal
2015/04/01 - 2015/07/29 Bio-engineering formation Cranfield Defence and Security, United Kingdom
2014/11/01 - 2015/03/29 Bio-engineering formation Oulun Yliopisto, Finland
2012/09/01 - 2012/11/29 Histomorphometry formation INSERM, France
2009/06/01 - 2012/01/02 Clinical Trials Coordinator Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2009/03/01 - 2011/12/31 Fellowship “Risco cardiovascular e inflamação – contribuição para a etiopatogenia da aterosclerose e da doença cardiovascular” PIC/IC/82920/2007. Instituto de Medicina Molecular, Portugal
2008/01/02 - 2008/01/26 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2007/11/01 - 2007/12/01 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital de Nossa Senhora do Rosário, Portugal
2007/10/01 - 2007/11/01 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital de Santa Maria, Portugal
2007/05/01 - 2007/06/01 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital Curry Cabral, Portugal
2007/04/01 - 2007/05/01 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital Curry Cabral, Portugal
2007/03/05 - 2007/03/30 Técnico de Anatomia Patológica Citológica e Tanatológica Hospital de São José, Portugal
Projects

Grant

Designation Funders
2017/05/04 - Current Preclinical evaluation of celastrol for the treatment of RA: long-term efficacy and safety in the chronic K/BxN mice model
Fundo de incentivo à investigação em Reumatologia
Post-doc Fellow
Ongoing
2012/01/01 - 2015/12/31 HOW EARLY INFLAMMATORY EVENTS AFFECT BONE NANO-PROPERTIES AT THE ONSET OF RHEUMATOID ARTHRITIS
SFRH/BD/81527/2011
 Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2015/12/31 HOW EARLY INFLAMMATORY EVENTS AFFECT BONE NANO-PROPERTIES AT THE ONSET OF RHEUMATOID ARTHRITIS
SFRH/BD/81527/2011
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/03 - 2011/12/31 Cardiovascular risk and inflammation- contribution to the etiopathogenesis of atherosclerosis and cardiovascular disease
PIC/IC/82920/2007
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2017/09/27 - Current The effect of tumor necrosis factor and NSAIDS on peripheral and axial inflammation in an animal model of spondyloarthritis
NA
Supervisor
Ongoing
2017/04/05 - Current Long term effect of tofacitinib on bone: friend or foe?
Pfizer/SPR prize
PhD Student Fellow
Ongoing
2017/04 - Current Long term effect of tofacitinib on bone: friend or foe?
Pfizer/SPR prize
 N/A
2021/10/01 - 2023/12/31 EARLY_JAKi: JAK-STAT signaling pathway as key to chronic arthritis onset
000
Post-doc
AbbVie Lda
Ongoing
2017 - 2022 Linking Biomechanics, Inflammation and Bone Formation in Psoriatic Arthritis.
000
Post-doc
Instituto de Medicina Molecular, Portugal
Ongoing
2017/11/23 - 2019/12/29 Carbon monoxide guided shuttles (COGSs) to fight Rheumatoid Arthritis
NA
Researcher
Concluded
2014/09/06 - 2017/04/30 HOW EARLY INFLAMMATORY EVENTS AFFECT BONE NANO-PROPERTIES AT THE ONSET OF RHEUMATOID ARTHRITIS
ECTS/AMGEN Bone Biology Prize 2014
Principal investigator
Fundação para a Ciência e a Tecnologia
2013/06/04 - 2016/10/30 Inhibition of bone and cartilage degradation in rat induced arthritis treated with tofacitinib
ASPIRE 2013 Pfizer
PhD Student Fellow
2010/03/05 - 2013/03/04 CORMRA (Development of carbon monoxide releasing molecules for the treatment of rheumatoid arthritis
FP7 Research - European commission
Research Fellow
Concluded
2011/01/01 - 2013/02/17 Projecto Estratégico - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/01/03 - 2011/12/31 Effects of inflammation on bone and cartilage: collagen pattern and biomechanical properties
info:eu-repo/grantAgreement/FCT/3599-PPCDT/65992/PT
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2019/10/17 - Current Marine-derived 3D printed biomimetic scaffolds for bone tissue regeneration
NA
Researcher
Ongoing
2018 - 2019 The effect of exercise and tumor necrosis factor inhibitor on peripheral and axial inflammation in an animal model of spondyloarthritis
000
Supervisor
Concluded
2015/01/26 - 2017/11/30 Linking Biomechanics, Inflammation and Bone Formation in Psoriatic Arthritis
NA
PhD Student Fellow
Concluded
2012/05/05 - 2017/10/05 Evaluation of celastrol as a candidate for the treatment of rheumatoid arthritis
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F928602%F2013/PT
PhD Student Fellow
2013/01/04 - 2014/12/19 Cálcio da concha de ostra e fibra alimentar solúvel" na prevenção da osteoporose num modelo animal
NA
Researcher
Concluded
2009/01/04 - 2012/01/03 Role of IL-1ß in Rheumatoid Arthritis
NA
Research Fellow
Concluded
2009/01/03 - 2011/12/31 Apoptotic mechanisms of osteoclasts in rheumatic diseases
NA
Research Fellow
Concluded
2009/01/03 - 2011/12/31 Structural and mechanical evaluation of the mineral and organic phases in osteoporotic bone using an animal model of osteoporosis
ECTS/Servier 2010 Award
Research Fellow
Concluded
2008/07/01 - 2011/12 FUNCTIONAL AND MOLECULAR STUDY OF NEUTROPHILS ROLE IN THE INITIATION AND PROGRESSION OF CHRONIC AUTOIMMUNE ARTHRITIS IN SKG MICE
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F405132%F2007/PT
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Agripino A; Cristina Mello-Sampayo; Stilwell, D.; Vidal, Bruno; Lopes, A.; Canhão, H.; Silva-Lima, B.; Marques MC. "Impacto da Diabetes Mellitus no osso de ratos ovariectomizados. Revista Portuguesa de Diabetes 9". Paper presented in 10º Congresso Português Diabetes, 2014.
Journal article
  1. Romão, Vasco C.; Polido-Pereira, Joaquim; Barros, Rita; Luís, Rita; Vidal, Bruno; Vieira-Sousa, Elsa; Vitorino, Emília; et al. "Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study". Arthritis Care & Research 72 10 (2020): 1497-1505. http://dx.doi.org/10.1002/acr.24050.
    10.1002/acr.24050
  2. Cascão, Rita; Vidal, Bruno; Carvalho, Tânia; Lopes, Inês Pascoal; Romão, Vasco C.; Goncalves, João; Moita, Luis Ferreira; Fonseca, João Eurico. "Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model". Frontiers in Medicine 7 (2020): http://dx.doi.org/10.3389/fmed.2020.00455.
    10.3389/fmed.2020.00455
  3. Rocha, Francisco Airton Castro; Girão, Virgínia Claudia Carneiro; Nunes, Rodolfo de Melo; Pinto, Ana Carolina Matias Dinelly; Vidal, Bruno; Fonseca, João Eurico. "Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus". PLOS ONE 14 12 (2019): e0226986. http://dx.doi.org/10.1371/journal.pone.0226986.
    10.1371/journal.pone.0226986
  4. Romão, Vasco C.; Polido-Pereira, Joaquim; Barros, Rita; Luís, Rita; Vidal, Bruno; Vieira-Sousa, Elsa; Vitorino, Emília; et al. "Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study". Arthritis Care & Research (2019): http://dx.doi.org/10.1002/acr.24050.
    10.1002/acr.24050
  5. Vidal, Bruno; Cascão, Rita; Finnilä, Mikko A J; Lopes, Inês P; da Glória, Vânia G; Saarakkala, Simo; Zioupos, Peter; Canhão, Helena; Fonseca, João Eurico. "Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model". Rheumatology 58 2 (2018): 371-371. http://dx.doi.org/10.1093/rheumatology/key377.
    10.1093/rheumatology/key377
  6. Vidal, Bruno; Cascão, Rita; Finnilä, Mikko A. J.; Lopes, Inês P.; Saarakkala, Simo; Zioupos, Peter; Canhão, Helena; Fonseca, João E.. "Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis". PLOS ONE 13 1 (2018): e0190920. http://dx.doi.org/10.1371/journal.pone.0190920.
    10.1371/journal.pone.0190920
  7. Cascão, Rita; Vidal, Bruno; Jalmari Finnilä, Mikko Arttu; Lopes, Inês Pascoal; Teixeira, Rui Lourenço; Saarakkala, Simo; Moita, Luis Ferreira; Fonseca, João Eurico. "Effect of celastrol on bone structure and mechanics in arthritic rats". RMD Open 3 2 (2017): e000438. http://dx.doi.org/10.1136/rmdopen-2017-000438.
    10.1136/rmdopen-2017-000438
  8. Vidal, Bruno; Cascão, Rita; Finnilä, Mikko A J; Lopes, Inês P; da Glória, Vânia G; Saarakkala, Simo; Zioupos, Peter; Canhão, Helena; Fonseca, João Eurico. "Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model". Rheumatology 57 8 (2017): 1461-1471. http://dx.doi.org/10.1093/rheumatology/kex258.
    10.1093/rheumatology/kex258
  9. de Mello-Sampayo, Cristina; Agripino, Alaíde Alves; Stilwell, Duarte; Vidal, Bruno; Fernando, Ana Luisa; Silva-Lima, Beatriz; Vaz, Maria Fátima; Canhão, Helena; Marques, M. Cristina. "Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures". International Journal of Endocrinology 2017 (2017): 1-9. http://dx.doi.org/10.1155/2017/4603247.
    10.1155/2017/4603247
  10. Cascão, Rita; Vidal, Bruno; Lopes, Inês P.; Paisana, Eunice; Rino, José; Moita, Luis F.; Fonseca, João E.. "Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats". PLOS ONE 10 12 (2015): e0142448. http://dx.doi.org/10.1371/journal.pone.0142448.
    10.1371/journal.pone.0142448
  11. Vidal, Bruno; Cascão, Rita; Vale, Ana Catarina; Cavaleiro, Inês; Vaz, Maria Fátima; Brito, José Américo Almeida; Canhão, Helena; Fonseca, João Eurico. "Arthritis Induces Early Bone High Turnover, Structural Degradation and Mechanical Weakness". PLOS ONE 10 1 (2015): e0117100. http://dx.doi.org/10.1371/journal.pone.0117100.
    10.1371/journal.pone.0117100
  12. Cascão, Rita; Vidal, Bruno; Raquel, Helena; Neves-Costa, Ana; Figueiredo, Nuno; Gupta, Vineet; Fonseca, João Eurico; Ferreira Moita, Luis. "Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis". Mediators of Inflammation 2014 (2014): 1-7. http://dx.doi.org/10.1155/2014/195327.
    10.1155/2014/195327
  13. Vale, Ana C.; Faustino, Jennifer; Reis, Luís; Lopes, Ana; Vidal, Bruno; Monteiro, Jacinto; Fonseca, João E.; Canhão, Helena; Vaz, Maria F.. "Effect of the Strain Rate on the Twisting of Trabecular Bone from Women with Hip Fracture". Journal of Biomechanical Engineering 135 12 (2013): http://dx.doi.org/10.1115/1.4025322.
    10.1115/1.4025322
  14. Caetano-Lopes, Joana; Rodrigues, Ana; Lopes, Ana; Vale, Ana C.; Pitts-Kiefer, Michael A.; Vidal, Bruno; Perpétuo, Inês P.; et al. "Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression". Clinical Reviews in Allergy & Immunology 47 1 (2013): 38-45. http://dx.doi.org/10.1007/s12016-013-8366-y.
    10.1007/s12016-013-8366-y
  15. Rodrigues, Ana M.; Caetano-Lopes, Joana; Vale, Ana C.; Vidal, Bruno; Lopes, Ana; Aleixo, Inês; Polido-Pereira, Joaquim; et al. "Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures". Bone 51 6 (2012): 981-989. http://dx.doi.org/10.1016/j.bone.2012.08.129.
    10.1016/j.bone.2012.08.129
  16. Cascão, R.; Vidal, B.; Raquel, H.; Neves-Costa, A.; Figueiredo, N.; Gupta, V.; Fonseca, J.E.; Moita, L.F.. "Effective treatment of rat adjuvant-induced arthritis by celastrol". Autoimmunity Reviews 11 12 (2012): 856-862. http://dx.doi.org/10.1016/j.autrev.2012.02.022.
    10.1016/j.autrev.2012.02.022
  17. Santos, Maria José; Carmona-Fernandes, Diana; Caetano-Lopes, Joana; Perpétuo, Inês P.; Vidal, Bruno; Capela, Susana; Canas da Silva, José; Fonseca, João Eurico. "TNF promoter -308 G>A and LTA 252 A>G polymorphisms in Portuguese patients with systemic lupus erythematosus". Rheumatology International 32 8 (2011): 2239-2244. http://dx.doi.org/10.1007/s00296-011-1950-7.
    10.1007/s00296-011-1950-7
  18. SANTOS, MARIA J.; FERNANDES, DIANA; CAETANO-LOPES, JOANA; PERPETUO, INÊS P.; VIDAL, BRUNO; CANHAO, HELENA; FONSECA, JOÃO E.. "Lymphotoxin-a 252 A>G Polymorphism: A Link Between Disease Susceptibility and Dyslipidemia in Rheumatoid Arthritis?". The Journal of Rheumatology 38 7 (2011): 1244-1249. http://dx.doi.org/10.3899/jrheum.101170.
    10.3899/jrheum.101170
Newspaper article
  1. Vidal, Bruno. "Bone histomorphometry revisited.", 2012
Thesis / Dissertation
  1. Vidal, Bruno. "How early inflammatory events affect bone nano-properties at Rheumatoid Arthritis onset". PhD, Universidade de Lisboa Faculdade de Medicina, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017 Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness ECTS
2016 Analyzing the effects of early arthritis in bone nanostructure Immunology Club
2016 Analyzing the effects of early arthritis in systemic bone loss CPR
2015 How early inflammatory events affect bone nano - properties at rheumatoid arthritis onset PhD Meeting
2012 How early inflammatory events affect bone nano - properties at rheumatoid arthritis onset 12th Medinterna International Meeting 2012

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/09 - 2019/12 The effect of tumor necrosis factor and NSAIDS on peripheral and axial inflammation in an animal model of spondyloarthritis
Supervisor
2016/10 - 2017/12 Efficacy and toxicity evaluation of celastrol in adjuvant-induced arthritis rat model
Co-supervisor
2016/10 - 2017/11 preclinical development of a new compound for the treatment of arthritis
Co-supervisor
2015/09 - 2016/11 Evaluation of celastrol as a candidate for the treatment of rheumatoid arthritis
Co-supervisor

Mentoring / Tutoring

Topic Student name
2015/09 - 2018/01 Mentor of biomedical engineer students from Instituto Superior Técnico de Lisboa. Several groups of students
Distinctions

Award

2017 JAKIE Sociedade Portuguesa de Reumatologia 2016
2014 ECTS/Amgen Bone Biology Fellowship
2013 ASPIRE 2013 – “Inhibition of bone and cartilage degradation in rat induced arthritis treated with tofacitinib”
2010 "Avaliação da qualidade do osso de epifises femorais e correlação com os factores de risco clínicos de fractura em doentes submetidos a artroplastia da anca"

Other distinction

2018 Fundo de apoio à investigação e formação Reumatológicas 2017
Sociedade Portuguesa de Reumatologia, Portugal