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Identification

Personal identification

Full name
Judite Raquel Martins Coimbra

Citation names

  • Coimbra, Judite RM

Author identifiers

Ciência ID
2516-A244-973A
ORCID iD
0000-0001-5913-3834

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2016/09/01 - 2023/06/19
Concluded
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Major in Química Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
"RATIONAL DRUG DESIGN OF NOVEL POTENT MULTIFUNCTIONAL AGENTS FOR ALZHEIMER’S DISEASE TREATMENT" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
2016/07/13
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Therapeutic targets in Alzheimer's Disease - Relevance of BACE1 and the inhibitors's development of this secretase" (THESIS/DISSERTATION)
 16
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2023/09 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/09 - 2023/08 Invited Assistant (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2019/04/01 - Current Rational Drug Design of novel potent multifunctional agents for Alzheimer’s Disease treatment
SFRH/BD/138460/2018
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/09/01 - 2019/03/31 Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos (Drugs2CAD)
CENTRO-01-0247-FEDER-003269
Research Fellow
Chem4Pharma, Portugal

Universidade de Coimbra, Portugal
Agência Nacional de Inovação SA
Concluded
Outputs

Publications

Conference poster
  1. Coimbra, Judite RM. "Novel Glutaminyl Cyclase Inhibitors Discovered by Molecular Modeling Studies". Paper presented in 8th EFMC Young Medicinal Chemists’ Symposium (EFMC-YMCS 2021), Virtual Meeting., 2021.
  2. Coimbra, Judite RM. "A Virtual Screening Protocol to Identify Novel Inhibitors of Glutaminyl Cyclase". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), Virtual Meeting., 2021.
  3. Coimbra, Judite. "Application of Computational Methods for Discovery of Novel BACE1 Hit Inhibitors: Ligand- and Structure-based Protocols with In Vitro Evaluation". Paper presented in 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, Aveiro, Portugal, 2020.
  4. Coimbra, Judite. "Targeting Alzheimer’s Disease: A Virtual Screening Protocol to Discover New Central-Acting BACE1 Inhibitors". Paper presented in Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, Orlando, FL, USA, 2019.
  5. Coimbra, Judite RM. "Targeting Alzheimer’s Disease: An Integrated Protocol of Virtual Screening for Discovery of Novel Anti-BACE1 Agents". Paper presented in Presented at the AD/PDTM 2019, the 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, Lisbon, Portugal, 2019.
  6. Coimbra, Judite. "Identification of Novel BACE1 Inhibitors: A Combined Protocol of Pharmacophore Modeling, Virtual Screening and Structure-based Drug Design". Paper presented in XXV EFMC International Symposium on Medicinal Chemistry, Ljubljana, Slovenia, 2018.
  7. Coimbra, Judite. "New BACE I Inhibitors: A Structure-based and Ligand-based Rational Drug Design. Pharmacophore Modeling and Virtual Screening". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, Coimbra, Portugal, 2018.
  8. Baptista, Salete J.; Coimbra, Judite. "Novel PARP-1 Inhibitor Scaffolds: A Dynamic-based Pharmacophore Approach". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, Coimbra, Portugal, 2018.
Journal article
  1. Judite R.M. Coimbra; Paula I. Moreira; Armanda E. Santos; Jorge A.R. Salvador. "Therapeutic potential of glutaminyl cyclases: current status and emerging trends". Drug Discovery Today (2023): 103644-103644. http://dx.doi.org/10.1016/j.drudis.2023.103644.
    10.1016/j.drudis.2023.103644
  2. Coimbra, Judite RM; Salvador, Jorge A.R.. Corresponding author: Salvador, Jorge A.R.. "A patent review of glutaminyl cyclase inhibitors (2004–present)". Expert Opinion on Therapeutic Patents 31 9 (2021): 809-836. http://dx.doi.org/10.1080/13543776.2021.1917549.
    10.1080/13543776.2021.1917549
  3. Coimbra, Judite RM. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer's Disease Models". Journal of Alzheimer's Disease (2020): http://doi.org/10.3233/JAD-200381.
    10.3233/JAD-200381
  4. Judite R. M. Coimbra; Salete J. Baptista; Teresa C. P. Dinis; Maria M. C. Silva; Paula I. Moreira; Armanda E. Santos; Jorge A. R. Salvador. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535-535. https://doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  5. Judite RM Coimbra; Pedro JM Sobral; Armanda E Santos; Paula I Moreira; Jorge AR Salvador. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry (2019): https://doi.org/10.4155/fmc-2019-0163.
    10.4155/fmc-2019-0163
  6. Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R.. "Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00178.
    Published • 10.3389/fchem.2018.00178
Magazine article
  1. Coimbra, Judite RM. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista?", Público, 2021, https://www.publico.pt/2021/09/15/ciencia/noticia/doencas-neurodegenerativas-quebracabecas-solucao-vista-1975912.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/12/19 In Silico Prediction and In Vitro Evaluation of New BACE1 Inhibitors for Alzheimer’s Disease CIBB Meeting 2019
CNC - Center for Neuroscience and Cell biology, UC (Coi, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/03 - Current Brain Awareness Week 2019 Participation in Scientific Communication events promoted by Center for Neuroscience and Cell Biology (CNC), University of Coimbra.
Other
 Brain Awareness Week 2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01 - Current Palestra: “Investigação em neurociências – Doenças da longevidade” em ação formativa de Curso em Yogaterapia promovido pela Federação Portuguesa de Yoga
Other
 Curso em Yogaterapia
Federação Portuguesa de Yoga, Portugal
2019/11 - Current 1st Annual Meeting in Pharmaceutical Sciences, FFUC
Meeting
 1st Annual Meeting in Pharmaceutical Sciences
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/11 - Current Science and Technology Week 2018 Participation in Scientific Communication events promoted by Center for Neuroscience and Cell Biology (CNC), University of Coimbra
Other
 Science and Technology Week 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/09 - Current The European Researchers' Night 2018 Participation in Scientific Communication events promoted by Center for Neuroscience and Cell Biology (CNC), University of Coimbra
Other
 The European Researchers' Night 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Association member

Society Organization name Role
2017/01/01 - Current Portuguese Chemical Society membro