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Rafael Tiago Pereira Martins Aroso. Completed the Doutoramento in Chemistry PhD in 2022/07/20 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Mestrado in Medicinal Chemistry MSc in 2017 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Medicinal Chemistry BSc in 2015 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Is Researcher in Universidade de Coimbra. Published 19 articles in journals. Has 2 section(s) of books. Has 1 patent(s) registered. Organized 9 event(s). Co-supervised 2 MSc dissertation(s). Has received 7 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 project(s), Post-doc Fellow in 1 project(s), Principal investigator in 1 project(s) and Researcher in 6 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry and Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Medicinal Chemistry. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Photosensitizer; Porphyrin; .
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Identification

Personal identification

Full name
Rafael Tiago Pereira Martins Aroso

Citation names

  • Aroso, Rafael T.

Author identifiers

Ciência ID
2515-3B84-6F8D
ORCID iD
0000-0002-2657-9212

Email addresses

  • rafaelaroso@uc.pt (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2017 - 2022/07/20
Concluded
 Chemistry PhD (Doutoramento)
Major in Medicinal Chemistry
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Computational design and synthesis of molecules for application in antimicrobial therapies" (THESIS/DISSERTATION)
2016 - 2017
Concluded
 Medicinal Chemistry MSc (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Synthesis and study of new photosensitizers with potential for antimicrobial therapy" (THESIS/DISSERTATION)
 18
2012 - 2015
Concluded
 Medicinal Chemistry BSc (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2023/03/20 - Current Researcher (Research) Universidade de Coimbra, Portugal
Projects

Grant

Designation Funders
2025/09/01 - 2027 PorphIRON - Design, synthesis and optimization of Fe(III) based porphyrins for use as next-generation MRI probes
101146991
Post-doc Fellow
Centre de Biophysique Moléculaire, France
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2022/10/25 - 2023/11/30 The Challenge of Microplastic Pollution and the Emergence of Bioplastics as a Forward-Thinking Solution: Engaging Society's Participation
Environmental Education Contest + Interdisciplinary + Inclusive + Participatory 2022
Researcher
Concluded
2018 - 2022 Computational design and synthesis of molecules for application in antimicrobial therapies
PD/BD/143123/2019
PhD Student Fellow
Associação para a Inovação e Desenvolvimento da FCT
Concluded

Contract

Designation Funders
2024/04 - 2025/03 Natural-based antibacterial bioplastics: a synergic and sustainable approach for surface photo-decontamination (PhotoBioSyn)
SeedProjects@UC
Principal investigator
Concluded
2024/01 - 2024/12 Photosensitive Carbon Dioxide-Based Polycarbonate Derivatives and Photo-Antimicrobial Polycarbonate-Bioplasticizer Composites (CO2PhotoBioPlas)
Projetos Provas de Conceito 2023
Researcher
Concluded

Other

Designation Funders
2021/01/01 - Current Institute of Molecular Sciences Associate Laboratory
LA/P/0056/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025 Deliver-Detect-Defeat (DDD): How to place macromolecules in target cells and make therapies work
PTDC/QUI-OUT/0303/2021
Researcher
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2023 Centro de Química - Coimbra
UID/QUI/00313/2020
Researcher
Universidade de Coimbra Centro de Química de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2022 Synthesis of bimodal molecules for photodynamic inactivation of multidrug-resistant bacteria by dual therapy
PTDC/QUI-OUT/27996/2017
Researcher
Ongoing
Outputs

Publications

Book chapter
  1. Aroso, Rafael T.; Pereira, Mariette M.. "Chapter 2 - Synthesis of porphyrins". In Synthesis Of Pyrrol-Based Bioconjugates - Perspectives And Applications. CRC Press - Taylor & Francis Group, 2024.
    Published
  2. Vinagreiro, Carolina S.; Aroso, Rafael T.; Dias, Lucas D.; Pereira, Mariette M.; Paixão, Fátima. "Resistência a antibióticos: também um problema de educação?". In A escola de aprender – Contributos para a sua construção. Castelo Branco, Portugal, 2019.
Conference abstract
  1. Arnaut, Zoe A.; Felgueiras, Alexandre P.; Rodrigues, Fábio M. S.; Aroso, Rafael T.; Pais, Alberto A. C. C.; Pereira, Mariette M.. "Factorial design for optimization of tetra-substituted meso-aryl porphyrins synthesis through flow chemistry". Paper presented in XXVIII Encontro Galego-Portugués de Química, Vigo, 2024.
    Published
  2. Silva, Madalena F. C.; Domingos, Carolina V.; Aroso, Rafael T.; Piccirillo, Giusi; Silva, Gabriela; Pereira, Mariette M.. "Broad-Spectrum Photosensitive Materials for Photodynamic Inactivation of Multidrug-Resistant Bacteria". Paper presented in XXVIII Encontro Galego-Portugués de Química, Vigo, 2024.
    Published
  3. Domingos, Carolina V.; Aroso, Rafael T.; Silva, Madalena F. C.; Silva, Gabriela; Pereira, Mariette M.. "PLA-Curcumin Biopolymers: Shining a Light onto Potential Photodecontaminating Materials". Paper presented in 35th Annual Conference of the Association for the Advancement of Industrial Crops (AAIC), Lisbon, 2024.
  4. Pereira, Mariette M.; Aroso, Rafael T.; Silva, Madalena F. C.; Domingos, Carolina V.. Corresponding author: Pereira, Mariette M.. "Synthesis of Porphyrins Through Continuous Flow Processes and Their Structural Effect on the Photoinactivation of bacteria". Paper presented in International Conference on Porphyrins and Phthalocyanines (ICPP-13), Buffalo, 2024.
    Accepted
  5. Domingos, Carolina V.; Rodrigues, Fábio M. S.; Tavares, Iúri; Aroso, Rafael T.; Calvete, Mário; Pereira, Mariette M.. "Shining Against Resistance: Photodecontaminant Materials for Inactivation of Bacteria". Paper presented in 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, Faro, 2024.
  6. Silva, Madalena F. C.; Aroso, Rafael T.; Arnaut, Zoe A.; Pereira, Mariette M.. "Synthesis of amphiphilic di-cationic imidazolyl porphyrins for photoinactivation of bacteria". Paper presented in 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, Faro, 2024.
  7. Silva, Madalena F. C.; Aroso, Rafael T.; Arnaut, Zoe A.; Pereira, Mariette M.. "Synthesis of amphiphilic di-cationic imidazolyl porphyrins for photoinactivation of bacteria". Paper presented in 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, Faro, 2024.
  8. Domingos, Carolina V.; Rodrigues, Fábio M. S.; Tavares, Iúri; Aroso, Rafael T.; Calvete, Mário J. F. ; Pereira, Mariette M.. "Shining Against Resistance: Photodecontaminant Materials for Inactivation of Bacteria". Paper presented in 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, Faro, 2024.
  9. Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Amorim, Anita; Lobo, Ana Catarina S. ; Pereira, Mariette M.; Arnaut, Luis G.. "Photoinactivation of SARS-CoV-2 using a cationic di-imidazolyl chlorin photosensitizer". Paper presented in 18th International Photodynamic Association World Congress, Tampere, 2023.
    Published
  10. Domingos, Carolina V.; Fábio M. S. Rodrigues; Tavares, Iúri; Aroso, Rafael T.; Calvete, Mário J. F. ; Pereira, Mariette M.. Corresponding author: Domingos, Carolina V.. "Filmes de PVC fotodescontaminantes incorporando derivados de curcumina como fotossensibilizadores bioplastificantes". Paper presented in Encontro Nacional de Estudantes de Química (ENEQUI), Porto, 2023.
    Published
  11. Aroso, Rafael T.; Pereira, Mariette M.. "With a little help from our antibiotic friends: synergic dual phototherapy for inactivation of gram-negative bacteria". Paper presented in 18th International Photodynamic Association World Congress, Tampere, 2023.
  12. Aroso, Rafael T.; Silva, Madalena F. C.; Pereira, Mariette M.. "Antimicrobial photodynamic therapy combined with antimicrobials: an alternative approach for eradication of gram-negative bacteria". Paper presented in 10th EFMC Young Medicinal Chemists' Symposium, Zagreb, 2023.
  13. Giusi Piccirillo; Aroso, Rafael T.; João A. Baptista; Canotilho, joao; Castro, Ricardo A. E.; Gabriela J. da Silva; Calvete, Mário J. F. ; Pereira, Mariette M.; M. Ermelinda S. Eusébio. "Active Pharmaceutical Ingredient's multicomponent solid forms: a contribution to enhance the trimethoprim biopharmaceutical performance". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022.
  14. Domingos, Carolina V.; Aroso, Rafael T.; Giusi Piccirillo; Teresa M. R. Maria; M. Ermelinda S. Eusébio; Castro, Ricardo A. E.; Gabriela J. da Silva; Carrilho, Rui M. B.; Pereira, Mariette M.. "Filmes de PLA-Curcumina: novos materiais fotodescontaminantes para embalagens alimentares". Paper presented in VIII Encontro Científico NEQ/AAC, Coimbra, 2022.
  15. Daniela S. S. Teixeira; Pinto, Sara M. A.; Aroso, Rafael T.; Pereira, Mariette M.. "Fluorinated contrast agents for application in 19F MRI and PET". Paper presented in XXVI Encontro Galego -Portugués de Química, Santiago de Compostela, 2022.
  16. Aroso, Rafael T.; Carrilho, Rui M. B.; Pereira, Mariette M.. "Cationic imidazolyl porphyrins bearing amphiphilic side chains combined with antimicrobials: new strategies to potentiate E. coli photodynamic inactivation". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, Santiago de Compostela, 2022.
    Published
  17. Carrilho, Rui M. B.; Aroso, Rafael T.; Giusi Piccirillo; Costa, Conceição; Paixão, Fátima; Pereira, Mariette M.. "Química Verde: Mudança de Paradigma no Ensino Experimental das Ciências". Paper presented in II Encontro de Supervisão e Avaliação na Vida das Escolas / V International Seminar on Science Education, Castelo Branco, 2022.
  18. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana Catarina S. ; Amorim, Anita; Calvete, Mário J. F. ; Rodrigues-Santos, Paulo; et al. "Synthesis of di-imidazolyl porphyrins and their chlorin derivatives for photoinactivation of bacteria and viruses". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  19. Aroso, Rafael T.; Dias, Lucas D.; Soares, Jennifer M.; Blanco, Kate; Bagnato, Vanderlei S.; Silva, Gabriela J.; Pereira, Mariette M.. "Synergic combination of photodynamic inactivation with antibiotics for the treatment of bacterial infections in vitro and in vivo studies". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, Almada, 2022.
    Published
  20. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana C. S.; Amorim, Anita S.; Calvete, Mário J. F. ; Pereira, Dina; et al. "Synthesis of di-imidazolyl porphyrins and their chlorin derivatives for photoinactivation of bacteria and viruses". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022.
  21. Arnaut, Luis G.; Pereira, Mariette M.; Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M. A.; Lobo, Ana Catarina S. ; Santos, Paulo-Rodrigues. "Photodynamic therapy for Covid-19 and other infectious diseases". Paper presented in 19th Congress of the European Society for Photobiology, Salzburg, 2021.
    Published
  22. Aroso, Rafael T.; Calvete, Mário J. F. ; Gonzalez, Andreia C. S.; Tomé, Vanessa A.; Damas, Liliana; Carrilho, Rui M. B.; Pereira, Mariette M.. "Sustainable methodologies for the synthesis of metallophthalocyanines". Paper presented in 11th International conference on porphyrins & phthalocyanines, Buffalo, 2021.
    Published
  23. Aroso, Rafael T.; Arnaut, Zoe A.; Guedes, Rita C.; Pereira, Mariette M.. "Computational Design And Synthesis Of Benzimidazole Derivatives For Potential E. coli Dna Gyrase B Inhibition". Paper presented in XXIX European Colloquium on Heterocyclic Chemistry, Rouen, 2021.
    Published
  24. Carrilho, Rui M. B.; Gonzalez, Andreia; Aroso, Rafael T.; Fábio M. S. Rodrigues; Pereira, Mariette M.. "Catalytic Synthetic Approaches Towards Photosensitive Bio-Polymers". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2021), Évora, 2021.
    Published
  25. Arnaut, Z. A.; Aroso, T. Rafael; Nunes, S. C. C.; Pais, A. A. C. C.; Pinto, S. M. A.; Pereira, M. M.. "Design and scale-up of amphiphilic cationic meso-imidazolyl porphyrin-based photosensitizers for development of potential antimicrobial agents". Paper presented in ECHC - XXIX European Colloquium on Heterocyclic Chemistry, Online, 2021.
    Published
  26. Gonzalez, A. C. S.; Cruz, I. G.; Aroso, Rafael T.; Tavares, I.; Rodrigues, F. M. S.; Carrilho, R. M. B.; Pereira, M. M.. "Sustainable Catalytic Processes for the Development of Photosensitive Polymeric Materials". Paper presented in XI National Meeting on Catalysis and Porous Materials, Online, 2021.
    Published
  27. Arnaut, Zoe A.; Aroso, Rafael T.; Nunes, Sandra C. C.; Pais, Alberto A. C. C.; Pinto, Sara M. A.; Pereira, Mariette M.. "Design and scale-up of amphiphilic cationic meso-imidazolylporphyrin-based photosensitizers for development of potential antimicrobial agents". Paper presented in ECHC - XXIX European Colloquium on Heterocyclic Chemistry, Rouen, 2021.
  28. Giusi Piccirillo; Calvete, Mário; Vinagreiro, Carolina S.; Aroso, Rafael T.; Pereira, Mariette M.. "Dealing with the (ab)use of antibiotics: hybrid materials for heterogeneous catalytic downstream treatment". Paper presented in Ciência 2019 - Science and Technology in Portugal Summit, Lisbon, 2019.
  29. Carrilho, Rui M. B.; Gonzalez, Andreia C. S.; Aroso, Rafael T.; Dias, Lucas D.; Pina, J; Pereira, Mariette M.. "Tetrapyrrolic Macrocycles: Synthesis, Characterization and Catalytic Applications in CO2 Conversion". Paper presented in 3rd International Symposium on Synthesis and Catalysis (ISySyCat2019), 2019.
    Published
  30. Aroso, Rafael T.; Carolina S. Vinagreiro; Janusz M. Dabrowski; Barbara Pucelik; Grzegorz Dubin; Luís G. Arnaut; Mario J.F. Calvete; Mariette M. Pereira. "Structure-activity relationships of cationic imidazolyl phthalocyanines for use as antimicrobial agents". Paper presented in Tenth International Conference on Porphyrins & Phthalocyanines, Munique, 2018.
    Published
  31. Carolina S. Vinagreiro; Aroso, Rafael T.; Luís G. Arnaut; Mariette M. Pereira. "Synthesis of subphthalocyanine derivatives as alternative antibacterial photosensitizing agents". Paper presented in Tenth International Conference on Porphyrins & Phthalocyanines, Munique, 2018.
    Published
  32. Carolina S. Vinagreiro; Aroso, Rafael T.; Lucas D. Dias; Mariette M. Pereira; Fátima Paixão. "Antibiotics Resistance: Also an educational problem?". Paper presented in II International Seminar on Science Education, Castelo Branco, 2018.
    Published
  33. Lucas D. Dias; Carolina S. Vinagreiro; Aroso, Rafael T.; Marta Piñeiro; Mariette M. Pereira; Fátima Paixão. "Green Chemistry Principles - The example of the Synthesis of Aspirin". Paper presented in II International Seminar on Science Education, Castelo Branco, 2018.
    Published
  34. Pereira, Mariette M.; Calvete, Mário J. F.; Pinto, Sara M. A.; Carrilho, Rui M. B.; Dias, Lucas D.; Vinagreiro, Carolina S.; Aroso, Rafael T.. "Tetrapyrrolic macrocycles: Contributions for a sustainable World". Paper presented in 7th EuCheMS Conference on Nitrogen Ligands, 2018.
    Published
  35. Carolina S. Vinagreiro; Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik; Robert Paczynski,; Luís G. Arnaut; Mário J.F. Calvete; Mariette M. Pereira. "New alternatives for classic antibiotics: Dual phototherapy". Paper presented in 2nd International Caparica Conference in Antibiotic Resistance, Lisboa, 2017.
    Published
  36. Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik,; Robert Paczynski; Luís G. Arnaut; Mário J.F. Calvete; Mariette M. Pereira. "Cationic phthalocyanines as a promising new approach for the inactivation of multi-resistant microorganisms". Paper presented in 3rd Symposium on Medicinal Chemistry of the University of Minho, Braga, 2017.
    Published
Conference poster
  1. Arnaut, Zoe A.; Felgueiras, Alexandre P.; Fábio M. S. Rodrigues; Aroso, Rafael T.; Alberto A.C.C. Pais; Pereira, Mariette M.. "Synthesis of various meso-aryl porphyrins using flow chemistry". Paper presented in 13th International Conference on Porphyrins and Phthalocyanines, 2024.
  2. Aroso, Rafael T.; Domingos, Carolina V.; Fábio M. S. Rodrigues; Gabriela J. da Silva; Carrilho, Rui M. B.; Pereira, Mariette M.. Corresponding author: Aroso, Rafael T.. "Unraveling the Impact of Photosensitizer Structure on the Antibacterial Prowess of Photodecontaminant Biopolymers". Paper presented in International Conference on Porphyrins and Phthalocyanines (ICPP-13), 2024.
  3. Silva, Madalena F. C.; Aroso, Rafael T.; Arnaut, Zoe A.; Dabrowski, Janusz M.; Pucelik, Barbara; Barzowska, Agata; Silva, Gabriela; Arnaut, Luis G.; Pereira, Mariette M.. Corresponding author: Silva, Madalena F. C.. "Structure-activity studies of di-cationic imidazolyl porphyrins for PDI of E. coli". Paper presented in 18th International Photodynamic Association World Congress, 2023.
  4. Gonzalez, Andreia C. S.; Aroso, Rafael T.; Carrilho, Rui M. B.; Pereira, Mariette M.. "Development of sustainable catalytic processes towards polymeric materials versus fine chemicals via CO2 addition to epoxides". Paper presented in XXVIII SPQ National Encounter, 2023.
  5. Gonzalez, Andreia C. S.; Cruz, Inês G. ; Aroso, Rafael T.; Carrilho, Rui M. B.; Pereira, Mariette M.. "Homogeneous versus Heterogeneous Catalysts in CO2 Addition Reactions to Epoxides". Paper presented in International Symposium on Synthesis and Catalysis 2023, 2023.
  6. Aroso, Rafael T.; Arnaut, Zoe A.; Domingos, Carolina V.; Pinto, Sara M. A.; Silva, M. C.; Dabrowski, J.M.; Pucelik, B.; et al. Corresponding author: Aroso, Rafael T.. "Cationic imidazolyl-based photosensitizers with near-infrared absorption for inactivaction of bacteria". Paper presented in Coimbra Chemistry Centre Day, 2022.
  7. Silva, Madalena F. C.; Aroso, Rafael T.; Silva, Gabriela; Fábio M. S. Rodrigues; Carrilho, Rui M. B.; Pereira, Mariette M.. Corresponding author: Silva, Madalena F. C.. "Development of potential antibacterial agents through sustainable synthetic strategies". Paper presented in XXVI Encontro galego português de química, 2022.
  8. Domingos, Carolina V.; Aroso, Rafael T.; Giusi Piccirillo; Teresa M. R. Maria; M. Ermelinda S. Eusébio; Castro, Ricardo A. E.; Gabriela J. da Silva; Carrilho, Rui M. B.; Pereira, Mariette M.. "Photosensitive Packaging Materials For Microorganism Photoinactivation". Paper presented in EuChemS 2022, 2022.
  9. Arnaut, Zoe A.; Aroso, Rafael T.; Pinto, Sara M.; Pereira, Mariette M.. "Scale-up of cationic meso-imidazolyl porphyrin photosensitizers as antimicrobial agents". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  10. Aroso, Rafael T.; Arnaut, Z. A.; Pinto, S. M. A.; Domingos, C. V.; Silva, M. C.; Dabrowski, J.M.; Pucelik, B.; et al. "Cationic imidazolyl-based photosensitizers with near-infrared absorption for inactivation of bacteria". Paper presented in Coimbra Chemistry Centre Day, 2022.
  11. Aroso, Rafael T.; Calvete, Mário J. F. ; Pucelik, Barbara; Dubin, Grzegorz; Arnaut, Luis G.; Dabrowski, Janusz; Pereira, Mariette M.. "Cationic imidazolyl photosensitizers for inactivation of microorganisms in sub-micromolar concentrations". Paper presented in 11th International conference on porphyrins & phthalocyanines, 2021.
  12. Arnaut, Zoe A.; Aroso, Rafael T.; Nunes, S. C. C.; Pais, A. A. C. C.; Pinto, Sara M. A.; Arnaut, Luis G.; Pereira, Mariette M.. "Computational design and synthesis of imidazolyl-tetrapyrrolic macrocycles-based photosensitizers for photodynamic inactivation of micro-organisms". Paper presented in 11th International Conference on Porphyrins and Phthalocyanines (ICPP-11), 2021.
  13. Rodrigues, F. M. S.; Piccirillo, G.; Gonzalez, A. C. S.; Aroso, Rafael T.; Felgueiras, A. P.; Marques, D. L.; Masliy, V. ; et al. "Reusable catalysts for the Development of Sustainable Processes". Paper presented in Catalysis Science & Technology 10th Anniversary Symposium, 2021.
  14. Gonzalez, A. C. S.; Cruz, I. G.; Aroso, Rafael T.; Tavares, I.; Rodrigues, F. M. S.; Dias, L. D.; Carrilho, R. M. B.; Pereira, M. M.. "Sustainable Synthesis of Photosensitive Polymeric Materials for Antimicrobial Applications". Paper presented in EFMC-YMCS Young Medicinal Chemists’ Symposium, 2021.
  15. Rodrigues, F. M. S.; Piccirillo, G.; Gonzalez, A. C. S.; Aroso, Rafael T.; Felgueiras, A. P.; Marques, D. L.; Masliy, V. ; et al. "Development of Sustainable Processes Using Reusable Catalysts". Paper presented in Coimbra Chemistry Centre Day, 2021.
  16. Gonzalez, A. C. S.; Cruz, I. G.; Aroso, Rafael T.; Tavares, I.; Rodrigues, F. M. S.; Carrilho, R. M. B.; Pereira, M. M.. "Photosensitive Polycarbonates for Antimicrobial Applications". Paper presented in 6th CATSUS Worksho, 2021.
  17. Aroso, Rafael T.; Carolina S. Vinagreiro; Janusz M. Dabrowski; Fabio Schaberle; Gabriela Jorge da Silva; Vanderlei S. Bagnato; Luis G. Arnaut; Mario J.F. Calvete; Mariette M. Pereira. "Structure-activity relationships of cationic imidazolyl photosensitizers for sub-micromolar inactivation of bacteria". Paper presented in 13th National Organic Chemistry Meeting - 6th National Medicinal Chemistry Meeting, 2020.
  18. Aroso, Rafael T.; Sara M. A. Pinto; Carolina S. Vinagreiro; Lucas D. Dias; Giusi Piccirillo; Mario J.F. Calvete; Mariette M. Pereira. "Investigação Científica E Educação: Mãos Dadas Para Combater Infeções Multirresistentes". Paper presented in XVIII Encontro Nacional de Educação em Ciências, 2019.
  19. Arnaut, Zoé A.; Pereira, Mariette M.; Aroso, Rafael T.; Pinto, Sara M. A.; Guedes, Rita C.. "The quest for new antibiotics: synthesis of potential DNA gyrase inhibitors". Paper presented in XXVI Encontro Nacional da SPQ, 2019.
  20. Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik; Grzegorz Dubin; Rita C. Guedes; Luis G. Arnaut; Mario J.F. Calvete; Mariette M. Pereira. "Cationic photosensitizers and protein inhibitors: finding new ways to target antimicrobial resistance". Paper presented in XXVI Encontro Nacional da SPQ, 2019.
  21. Arnaut, Zoe A.; Aroso, Rafael T.; Rita C. Guedes; Sara M. A. Pinto; Mariette M. Pereira. "XXVI Encontro Nacional da SPQ". Paper presented in The quest for new antibiotics: synthesis of potential DNA gyrase inhibitors, 2019.
  22. Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik; Grzegorz Dubin; Luís G. Arnaut; Mario J.F. Calvete; Mariette M. Pereira. "Cationic Imidazolyl Phthalocyanines: Structure-activity Studies for Antimicrobial Therapy". Paper presented in São Paulo School of Advanced Science on Modern Topics in Biophotonics, 2019.
  23. Gonzalez, Andreia C. S.; Aroso, Rafael T.; Dias, Lucas D.; Carrilho, Rui M. B.; Pina, João; Pereira, Mariette M.. "Terpene-based metallophthalocyanines: Synthesis, characterization and catalytic applications in CO2 activation". Paper presented in XXVI National Meeting of the Portuguese Chemical Society (XXIV ENSPQ), 2019.
  24. Carolina S. Vinagreiro,; Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik; Robert Paczynski; Luís G. Arnaut; Mario J.F. Calvete; Mariette M. Pereira. "Development of new metal-based antimicrobial agents". Paper presented in EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 2017.
  25. Vanessa A. Tomé; Mário J.F. Calvete; Carolina S. Vinagreiro; Aroso, Rafael T.; Mariette M. Pereira. "Development of new NIR dyes by Pd-catalyzed aminocarbonylation". Paper presented in XXV SPQ National Congress, 2017.
  26. Aroso, Rafael T.; Janusz M. Dabrowski; Barbara Pucelik; Robert Paczynski; Luís G. Arnaut; Mário J.F. Calvete; Mariette M. Pereira. "Cationic imidazolyl phthalocyanines as promising photosensitizers for antimicrobial therapy". Paper presented in 16th International Photodynamic Association World Congress, 2017.
  27. Aroso, Rafael T.; Carolina S. Vinagreiro; Barbara Pucelik; Janusz M. Dabrowski; Robert Paczynski; Luís G. Arnaut; Mário J.F. Calvete; Mariette M. Pereira. "Tetrapyrrolic photosensitizers: are they the future for antimicrobial therapy?". Paper presented in Coimbra Chemistry Centre Day 2016, 2016.
Journal article
  1. Szuroczki, Péter; Mikle, Gábor; Aroso, Rafael T.; Arnaut, Zoe A.; Pinto, Sara M. A.; Carrilho, Rui M. B.; Bényei, Attila; Kollár, László; Pereira, Mariette M.. "Unlocking New Porphyrin Aminoacid Bioconjugates with a Pd-Catalyzed Carboxamide Synthesis". ChemPlusChem (2025): https://doi.org/10.1002/cplu.202500193.
    10.1002/cplu.202500193
  2. Pinto, Sara Martinho Almeida; Lacerda, Sara; Morfin, Jean-François; Aroso, Rafael Tiago;  Teixeira, Daniela Sofia de Sousa; Garda, Zoltán; Pereira, Maria Miguens;  Geraldes, Carlos Frederico Gusmão Campos; Tóth, Éva. "Towards more efficient, more specific, and safer MRI contrast agents: a Portuguese–French collaborative journey". Comptes Rendus. Chimie 28 G1 (2025): 95-110. https://doi.org/10.5802/crchim.363.
    10.5802/crchim.363
  3. Marques, Diana L.; Piccirillo, Giusi; Rodrigues, Fábio M. S.; Aroso, Rafael T.; Dias, Lucas D.; da Silva, Gabriela J.; Calvete, Mário J. F.; Pereira, Mariette M.. "Advancing continuous flow techniques in effective trimethoprim oxidation: combatting bacterial resistance in wastewater". Chemical Communications 61 3 (2025): 480-483. https://doi.org/10.1039/d4cc04504a.
    10.1039/d4cc04504a
  4. Piccirillo, Giusi; Aroso, Rafael; Baptista, João A.; A. E. Castro, Ricardo; da Silva, Gabriela J.; Calvete, Mário J.F.; Pereira, Mariette M.; Canotilho, João; Ermelinda S. Eusébio, M.. "Trimethoprim-Based multicomponent solid Systems: Mechanochemical Screening, characterization and antibacterial activity assessment". International Journal of Pharmaceutics 661 (2024): 124416. https://doi.org/10.1016/j.ijpharm.2024.124416.
    10.1016/j.ijpharm.2024.124416
  5. Silva, Madalena F. C.; Aroso, Rafael T.; Dabrowski, Janusz M.; Pucelik, Barbara; Barzowska, Agata; Silva, Gabriela; Arnaut, Luis G.; Pereira, Mariette M.. Corresponding author: Pereira, Mariette M.. "Photodynamic inactivation of E. coli with cationic imidazolyl-porphyrin photosensitizers and their synergic combination with antimicrobial cinnamaldehyde". Photochemical & Photobiological Sciences 23 (2024): 1129-1142. https://link.springer.com/article/10.1007/s43630-024-00581-y.
    Published
  6. Arnaut, Zoe A.; Pinto, Sara M. A.; Aroso, Rafael T.; Amorim, Anita S.; Lobo, Catarina S.; Schaberle, Fabio A.; Pereira, Dina; et al. "Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers". Photochemical & Photobiological Sciences 22 11 (2023): 2607-2620. http://dx.doi.org/10.1007/s43630-023-00476-4.
    10.1007/s43630-023-00476-4
  7. Rodrigues, Fábio M. S.; Tavares, Iúri; Aroso, Rafael T.; Dias, Lucas D.; Domingos, Carolina V.; de Faria, Clara M. G.; Piccirillo, Giusi; et al. "Photoantibacterial Poly(vinyl)chloride Films Applying Curcumin Derivatives as Bio-Based Plasticizers and Photosensitizers". Molecules 28 5 (2023): 2209. http://dx.doi.org/10.3390/molecules28052209.
    10.3390/molecules28052209
  8. Teixeira, Daniela S.S.; Aroso, Rafael T.; Almeida, Joseany M. S.; Brett, Christopher M.A.; Calvete, Mário J.F.; Pinto, Sara M.A.; Pereira, Mariette M.. "Microwave synthesis of cationic ABAB di-imidazolyl fluorinated porphyrins and manganese complexes". Journal of Porphyrins and Phthalocyanines 27 01n04 (2023): 614-626. http://dx.doi.org/10.1142/s1088424623500475.
    10.1142/s1088424623500475
  9. Aroso, Rafael T.; Piccirillo, Giusi; Dias, Lucas D.; Pinto, Sara M. A.; Arnaut, Luís G.; Pereira, Mariette M.. "Synthesis of Photosensitizers Based on Tetrapyrrolic Macrocycles for Combination with Antibiotics: Dual Inactivation of Bacteria". ChemPlusChem 87 11 (2022): http://dx.doi.org/10.1002/cplu.202200228.
    10.1002/cplu.202200228
  10. Rafael T. Aroso. "Synergic dual phototherapy: Cationic imidazolyl photosensitizers and ciprofloxacin for eradication of in vitro and in vivo E. coli infections". Journal of Photochemistry and Photobiology B: Biology 233 (2022): 112499-112499. http://dx.doi.org/10.1016/j.jphotobiol.2022.112499.
    10.1016/j.jphotobiol.2022.112499
  11. Piccirillo, Giusi; Aroso, Rafael T.; Rodrigues, Fábio M. S.; Carrilho, Rui M. B.; Pinto, Sara M. A.; Calvete, Mário J. F.; Pereira, Mariette M.. "Oxidative Degradation of Pharmaceuticals: The Role of Tetrapyrrole-Based Catalysts". Catalysts 11 11 (2021): 1335. http://dx.doi.org/10.3390/catal11111335.
    Published • 10.3390/catal11111335
  12. Aroso, Rafael T.; Schaberle, Fábio A.; Arnaut, Luís G.; Pereira, Mariette M.. "Photodynamic disinfection and its role in controlling infectious diseases". Photochemical & Photobiological Sciences 20 11 (2021): 1497-1545. http://dx.doi.org/10.1007/s43630-021-00102-1.
    Published • 10.1007/s43630-021-00102-1
  13. Gonzalez, Andreia C.S.; Felgueiras, Alexandre P.; Aroso, Rafael T.; Carrilho, Rui M.B.; Pereira, Mariette M.. "Al(III) phthalocyanine catalysts for CO2 addition to epoxides: Fine-tunable selectivity for cyclic carbonates versus polycarbonates". Journal of Organometallic Chemistry 950 (2021): 121979. http://dx.doi.org/10.1016/j.jorganchem.2021.121979.
    Published • 10.1016/j.jorganchem.2021.121979
  14. Aroso, Rafael T.; Guedes, Rita (5F1E-E3BE-991C); Pereira, Mariette M.. "Synthesis of Computationally Designed 2,5(6)-Benzimidazole Derivatives Via Pd-Catalyzed Reactions for Potential E. coli DNA Gyrase B Inhibition". Molecules 26 1326 (2021): 1-19.
    Open access • Published • 10.3390/ molecules26051326
  15. Gonzalez, Andreia C. S.; Aroso, Rafael T.; Carrilho, Rui M. B.; Claver, Carmen; Masdeu-Bulltó, Anna M.; Pereira, Mariette M.. "Sustainable Synthesis of Polymeric Materials versus Fine Chemicals via CO2 Addition to Epoxides". Chemistry Proceedings 3 (2021): 17. https://doi.org/10.3390/ecsoc-24-08357.
    Published • 10.3390/ecsoc-24-08357
  16. Aroso, Rafael T.; Giusi Piccirillo; Arnaut, Zoe A.; Gonzalez, Andreia C. S.; Rodrigues, Fábio M. S.; Pereira, Mariette M.. "Photodynamic inactivation of influenza virus as a potential alternative for the control of respiratory tract infections". Journal of Photochemistry and Photobiology (2021): 100043. 10.1016/j.jpap.2021.100043.
    Published • 10.1016/j.jpap.2021.100043
  17. Gonzalez, Andreia C. S.; Damas, Liliana; Aroso, Rafael T.; Tomé, Vanessa A.; Dias, Lucas D.; Pina, João; Carrilho, Rui M. B.; Pereira, Mariette M.. "Monoterpene-based metallophthalocyanines: Sustainable synthetic approaches and photophysical studies". Journal of Porphyrins and Phthalocyanines (2020): A-L. http://dx.doi.org/10.1142/s1088424620500066.
    10.1142/s1088424620500066
  18. Aroso, Rafael T.; Calvete, Mário J.F.; Pucelik, Barbara; Dubin, Grzegorz; Arnaut, Luis G.; Pereira, Mariette M.; Dabrowski, Janusz M.. "Photoinactivation of microorganisms with sub-micromolar concentrations of imidazolium metallophthalocyanine salts". European Journal of Medicinal Chemistry 184 (2019): 111740. http://dx.doi.org/10.1016/j.ejmech.2019.111740.
    10.1016/j.ejmech.2019.111740
  19. Tomé, Vanessa; Calvete, Mário; Vinagreiro, Carolina; Aroso, Rafael T.; Pereira, Mariette. "A New Tool in the Quest for Biocompatible Phthalocyanines: Palladium Catalyzed Aminocarbonylation for Amide Substituted Phthalonitriles and Illustrative Phthalocyanines Thereof". Catalysts 8 10 (2018): 480. http://dx.doi.org/10.3390/catal8100480.
    10.3390/catal8100480
Thesis / Dissertation
  1. Aroso, Rafael T.. "Synthesis and study of new photosensitizers with potential for antimicrobial therapy". Master, Universidade de Coimbra, 2017.

Intellectual property

Patent
  1. Carrilho, Rui M. B.; Pereira, Mariette M.; Gonzalez, Andreia; Aroso, Rafael T.; Piccirillo, Giusi; Rodrigues, Fábio M. S.. 2025. "Novel photosensitive carbon dioxide based polycarbonate derivatives and method for preparation of photoantimicrobial polycarbonate-bioplasticizer composites and their use".
Provisional application for patent
  1. 2020. "SMALL CATIONIC ORTHO-5,15-DI-HETEROARYL-CHLORIN AND BACTERIOCHLORIN DERIVATIVES AND THEIR APPLICATIONS IN PHOTOINACTIVATION OF MICROORGANISMS".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 Combinação sinérgica de inativação fotodinâmica com agentes antimicrobianos na inativação de E. coli: estudos in vitro e in vivo / Synergistic combination of photodynamic inactivation with antimicrobial agents in the inactivation of E. coli: in vitro and in vivo studies IX Encontro Científico do NEQ/AAC
University of Coimbra (Coimbra, Portugal)
2023 Combinação sinérgica de inativação fotodinâmica com agentes antimicrobianos na inativação de E. coli: estudos in vitro e in vivo IX Encontro Científico do NEQ/AAC
(Coimbra, Portugal)
2023 Química na melhoria da Saúde Pública: Estratégias para diminuição de microorganismos multirresistentes / Chemistry in the improvement of Public Health: Strategies for the reduction of multiresistant microorganisms High-school teachers participating in Junior Chemistry Olympics 2023 edition semi-final at the Department of Chemistry
Universidade de Coimbra (Coimbra, Portugal)
2023 Química na melhoria da Saúde Pública: Contribuições do grupo de Química Medicinal da Universidade de Coimbra / Chemistry in the improvement of Public Health: Contributions of the Medicinal Chemistry group of the University of Coimbra High-school students participating in Escola Molecular
Universidade de Coimbra (Coimbra, Portugal)
2022 Bioplásticos – Moléculas Mais Sustentáveis / Bioplastics – More Sustainable Molecules High school student within the scope of Escola Molecular activities
Universidade de Coimbra (Coimbra, Portugal)
2021/06/05 Combate aos microrganismos multi-resistentes: novos desafios da química / Fighting against multi-drug resistant microoganisms: chemistry's new challenges Escola Molecular da FCTUC
Universidade de Coimbra (Coimbra, Portugal)
2021/06/02 Como vencer os microorganismos? Contribuições da educação e ciência / How to beat microorganisms? Contributions of science and edutcation LABFCTUC
Agrupamento de Escolas Dr. Manuel Gomes de Almeida (Espinho, Portugal)
2021 Combate Aos Microrganismos Multiresistentes: Novos Desafios Da Química / Combating Multiresistent Microorganisms: New Challenges of Chemistry High-school students participating in Escola Molecular
Universidade de Coimbra (Coimbra, Portugal)
2021 Como Vencer Os Microorganismos? Contribuições Da Educação E Ciência / How to overcome microorganisms? Contributions from Education and Science labFCTUC activities, to a 12th grade class of Agrupamento de Escolas Dr. Manuel Gomes de Almeida
Agrupamento de Escolas Dr. Manuel Gomes de Almeida (Espinho, Portugal)
2020/01/09 Bactérias Multirresistentes aos antibióticos: Ciência e Educação para a Saúde / Antibiotic multiresistant bacteria: Science and Health Education Jornada Científica e Cultural - Rumos da Ciência
Instituto Politécnico de Castelo Branco (Castelo Branco, Portugal)
2019 Bactérias Multirresistentes aos antibióticos: Ciência e Educação para a Saúde / Multiresistant bacteria to antibiotics: Science and Education for Health Jornada Científica e Cultural – Rumos da Ciência
Escola Superior de Educação - Instituto Politécnico de Castelo Branco (Castelo Branco, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/04 - 2025/04 Fotoinactivação de bactérias/Bacterial photoinactivation
Co-supervisor of Tomás Domingues
 Laboratory Rotation - MSc in Medicinal Chemistry (Other)
Universidade de Coimbra, Portugal
2024/03 - 2024/09 Síntese de fotossensibilizadores para potencial aplicação médica fotodinâmica/Photosensitizer synthesis for potential medical application in photodynamics
Co-supervisor of João Jordão
 Internship - BSc in Medicinal Chemistry (Other)
Universidade de Coimbra, Portugal
2023 - 2024 Funcionalização de fotossensibilizadores para preparação de bioconjugados/Photosensitizer functionalization for the preparation of bioconjugates
Co-supervisor of Yonathan Reis
 Medicinal Chemistry (Master)
Universidade de Coimbra, Portugal
2022/07 - 2023/07 Materiais Fotossensíveis para Fotoinativação de Microrganismos / Photosensitive Materials for Microorganism Photoinactivation
Co-supervisor of Carolina Valente Domingos
 Química (Master)
Universidade de Coimbra, Portugal
2023 - 2023 Síntese de fotossenssibilizadores fluorados para preparação de bioconjugados/Synthesis and characterization of fluorinated photosensitizers for preparation of bioconjugates
Co-supervisor of Yonathan Reis
 Laboratory Rotation - MSc in Medicinal Chemistry (Other)
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/04/05 - Current Junior Chemistry Olympics 2025 edition semi-final (2025/04/05)
Other (Member of the Organising Committee)
2025/03/15 - Current Chemistry Olympics + 2025 edition semi-final (2025/03/15)
Other (Member of the Organising Committee)
2024/04/13 - Current Junior Chemistry Olympics 2024 edition semi-final (2024/04/13)
Other (Member of the Organising Committee)
2024/03/09 - Current Chemistry Olympics + 2024 edition semi-final (2024/03/09)
Other (Member of the Organising Committee)
2023 - Current Junior Chemistry Olympics 2023 edition semi-final (2023)
Other (Member of the Organising Committee)
2022 - Current Junior Chemistry Olympics 2022 edition semi-final (2022)
Other (Member of the Organising Committee)
2018 - Current XXVI Congresso Ibero-Americano de Catálise (2018)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2018 - Current Junior Chemistry Olympics 2018 edition semi-final (2018)
Other (Member of the Organising Committee)
2017 - 2017 16th International Photodynamic Association World Congress (2017)
Congress (Member of the Organising Committee)
 Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025/02/13 Estudo dos efeitos da inativação fotodinâmica na persistência bacteriana a antibióticos / Study of the effects of photodynamic inactivation in bacterial persistance to antibiotics
(Thesis) Main arguer
 Bruna Carolina Corrêa (Master)
Universidade de São Paulo Instituto de Física de São Carlos, Brazil
2023 Síntese e caraterização de fotossensibilizadores / Synthesis and characterization of photosensitizers - BSc Internship
(Thesis) Main arguer
 Juliana Cebola (Other)
Universidade de Coimbra, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - 2025 Invited Assistant Professor: Analytical Chemistry Chemical Engineering (Licenciatura) Universidade de Coimbra, Portugal
2023 - 2025 Invited Assistant Professor: Organic Chemistry I Chemistry (Licenciatura) Universidade de Coimbra, Portugal
2023 - 2025 Invited Assistant Professor: Tutorial in Chemistry Chemistry (Licenciatura) Universidade de Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2023 - 2024 Pharmaceuticals - Guest Editor MDPI

Mentoring / Tutoring

Topic Student name
2021/07 - 2022/09 Master Thesis: Desenvolvimento de potenciais agentes antibacterianos através de estratégias sintéticas sustentáveis (Development of potential antibacterial agents through sustainable synthetic approaches) Madalena Figueiredo Cunha e Silva
2022/02 - 2022/06 Laboratory internship - Preparação e caracterização de filmes fotossensíveis tendo em vista a inativação de bactérias / Preparation and caracterization of photosensitive films for bacterial inactivation Carolina Valente Domingos
2021/04/01 - 2021/07/01 Laboratory internship: Síntese de fotossensibilizadores catiónicos - potenciais antimicrobianos / Synthesis of cationic photosensitizers - potential antimicrobials Madalena Figueiredo Cunha e Silva
2021/03/01 - 2021/07/01 Laboratory internship: Síntese de fotossensibilizadores para inativação fotodinâmica de microrganismos / Synthesis of photosensitizers for microorganism photodynamic inactivation Carolina Valente Domingos
2021/04 - 2021/05 Laboratory internship: Estudo de possíveis fotossensibilizadores para terapia fotodinâmica antimicrobiana / Study of potential photosensitizers for antimicrobial photodynamic therapy Anita Amorim
Distinctions

Award

2022 Team member of "Prix Tremplin Mariano Gago De Cooperation Bilaterale En Recherche - Portugal" award, with project titled: Metal-based contrast agents for specific visualisation of biomarkers in Magnetic Resonance Imaging
2022 Team member of “Prémio Semente de Investigação Interdisciplinar” Project: Biofilter for Carbon Dioxide Capture and Valorization: A Sustainable Approach towards Environment, Health and Circular Economy (CO2BioFilter)
2018 Prof. António Jorge Andrade Gouveia award 2016/17
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Universidade de Coimbra, Portugal
2017 Angelini University Award 16/17 - Audience awards for best communication
Angelini Farmacéutica España, Spain

Other distinction

2015 3% best students 2014/2015
Universidade de Coimbra, Portugal
2014 3% best students 2013/2014
Universidade de Coimbra, Portugal
2013 3% best students 2012/2013
Universidade de Coimbra, Portugal