???global.info.a_carregar???
Miguel C Seabra, MD, PhD, is a leading researcher in the field of cellular and molecular medicine. MS holds a PhD from University of Texas Southwestern Medical Center (1992), where he was an Assistant Professor, before moving to the Faculty of Medicine, Imperial College London where he became Full Professor and head of Section until 2007. MS is now Full Professor at the Medical School of the Universidade Nova de Lisboa, Portugal, where he coordinates research in Cellular and Molecular Medicine and holds several chairs. More recently, he became Head of Global Eye Initiative at Fundação Champalimaud. MS was president of Fundação para a Ciência e a Tecnologia (FCT) from 2012 to 2015, the portuguese public funding agency for science and research in Portugal. He is Principal Investigador and Group Leader of the Molecular Mechanisms of Disease group at NMS-UNL, with 3 post-doctoral researchers, 2 PhD students in training and 1 Lab technician. In 2021 also became the Head of Global Eye Initiative, Fundação Champalimaud, where his research group is starting activities in 2022. Published 172 articles in journals, with more than 18000 citations (h-Index=70). In the world ranking of scientists in all areas by Ioannidis et al, he ranks 0.22% top globally and one of the portuguese top 10. Has 4 sections of books and 1 book. Has 1 patent registered and funded 2 biotechnology companies. Since 1996, supervised 22 PhD thesis and an average of 3 BSc and Masters students/year. Has received 10 awards and/or honors. Participates and/or participated as Principal investigator in dozens of projects, raising about ~10 million as Principal Investigator. Moreover, MS has provided remarkable contributions to the elucidation of the cellular and molecular mechanisms underlying Choroideremia and has been the leader of a pioneering clinical trial of Choroideremia gene therapy.
Identification

Personal identification

Full name
Miguel Seabra

Citation names

  • Seabra, MC
  • Miguel C. Seabra

Author identifiers

Ciência ID
2512-FAEF-E26F
ORCID iD
0000-0002-6404-4892
Researcher Id
M-3280-2013
Scopus Author Id
7004369652

Addresses

  • Nova Medical SchoolFaculdade de Ciências Médicas, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Proficiency (C2) Proficiency (C2) Upper intermediate (B2) Proficiency (C2) Upper intermediate (B2)
Spanish; Castilian Proficiency (C2) Upper intermediate (B2) Elementary (A2) Proficiency (C2) Upper intermediate (B2)
Education
Degree Classification
2011
Concluded
Habilitation in Biochemistry (Título de Agregado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Very good with distinction and unanimous praise
1988 - 1992
Concluded
PhD in Biochemistry and Molecular Biology (Doutoramento)
The University of Texas Southwestern Medical Center, United States
"Protein Prenyltransferases: A family of enzymes that modify GTP-binding proteins" (THESIS/DISSERTATION)
1980 - 1986
Concluded
Medicine (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Affiliation

Science

Category
Host institution
Employer
2006 - 2011 Principal Investigator (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
1992 - 1994 Research Trainee (Research) The University of Texas Southwestern Medical Center, United States

Teaching in Higher Education

Category
Host institution
Employer
2016 - Current Invited Full Professor (University Teacher) University College London Institute of Ophthalmology, United Kingdom
2007 - Current Full Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007 - 2015 Invited Full Professor (University Teacher) Imperial College London Faculty of Medicine, United Kingdom
Imperial College London Faculty of Medicine, United Kingdom
1999 - 2007 Full Professor (University Teacher) Imperial College London Faculty of Medicine, United Kingdom
Imperial College London Faculty of Medicine, United Kingdom
1997 - 1999 Associate Professor (University Teacher) Imperial College London Faculty of Medicine, United Kingdom
1994 - 1997 Assistant Professor (University Teacher) The University of Texas Southwestern Medical Center, United States
The University of Texas Southwestern Medical Center, United States

Positions / Appointments

Category
Host institution
Employer
2014 - 2015 President Science Europe, Belgium
2012 - 2015 President Fundação para a Ciência e a Tecnologia, Portugal
2009 - 2011 Organic Unit Director Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Others

Category
Host institution
Employer
2021 - Current Head of Global Eye Initiative Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
Projects

Contract

Designation Funders
2023/01/01 - Current CRISPR-Based Gene Editing for Choroideremia (50Keuros)
THROSSELL AND HILLIER FAMILIES RESEARCH AWARD
Principal investigator
Choroideremia Research Foundation, Inc., United States
Choroideremia Research Foundation, Inc.
Ongoing
2022/12/01 - 2025/11/30 NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration- La caixa Foundation (980 keuros)
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
La Caixa Foundation
Ongoing
2018/10/01 - 2022/06/30 Lysosome dysfunction in age-related diseases (240 keuros)
PTDC/MED-PAT/30385/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10 - 2022/06 Lysosome dysfunction in age-related diseases (240 keuros)
PTDC/MED-PAT/30385/2017
Fundação para a Ciência e a Tecnologia
2018/10/01 - 2022/03/30 Co-PI: Recovering neuronal function and promoting neuroprotection in diabetic retinopathy
PTDC/MED-PAT/29656/2017
Other
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Co-PI: A exocitose de lisossomas disfuncionais como novo paradigma na patogénese da aterosclerose
PTDC/MED-PAT/29395/2017
Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2021/09/30 Co-PI: Mecanismos moleculares de internalização e processamento de melanina por queratinócitos
PTDC/BIA-CEL/29765/2017
Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2020/06/30 Mechanisms of Cell Death in Choroideremia (180 Keuros)
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Choroideremia Research Foundation, Inc.
Concluded
2017/05/08 - 2020/05/07 Bioengineered in vitro model of retinal pigmented epithelium of human eye (100 Keuros)
M-ERA-NET2/0005/2016
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/09/01 - 2019/11/30 Correction of lysosomal dysfunction in Retinal Pigmented Epithelial (RPE) cells (325 Keuros)
__
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Boehringer Ingelheim Auslandsbeteiligungs GmbH
Concluded
2008/01/01 - 2010/12/31 Molecular mechanisms of organelle motility
PTDC/BIA-BCM/73146/2006
Principal investigator
Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/10/01 - 2010/03/31 Molecular mechanisms of formation of the parasitic vacuole in Malaria infection
PTDC/SAU-MII/72027/2006
Principal investigator
Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Seabra, Miguel. Choroideremia. 2015.
    10.1201/B14734-13
Book chapter
  1. "Age-related diseases: common mechanisms and therapeutic approaches". In Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata. Portugal: Universidade Nova de Lisboa and Fundação Amélia de Mello, 2021.
    Published
  2. Pereira-Leal, José B.; Gomes, Anita Q.; Seabra, Miguel C.. "Analysis and Preparation of Stable Complexes between Rab GTPases, Rab Escort Protein, and Rab Geranylgeranyl Transferase". In GTPase Protocols, 157-165. Humana Press, 2002.
    10.1385/1-59259-281-3:157
  3. Seabra, Miguel C.. "6 Biochemistry of Rab geranylgeranyltransferase". In Protein Lipidation, 131-154. Elsevier, 2001.
    Published • 10.1016/s1874-6047(01)80019-6
  4. Seabra, M.C.; James, G.L.; Seabra, Miguel. "Prenylation assays for small GTPases.". In Methods in molecular biology (Clifton, N.J.), 251-260. 1998.
    10.1385/0-89603-488-7:251
  5. Armstrong, Scott A.; Brown, Michael S.; Goldstein, Joseph L.; Seabra, Miguel C.. "[5] Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins". In Small GTPases and Their Regulators Part C: Proteins Involved in Transport, 30-41. Elsevier, 1995.
    10.1016/s0076-6879(95)57007-1
Conference abstract
  1. "Impairement of chorioretinal vasculature in patients with intermediate age-related macular degeneration.". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
  2. "Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
  3. "Effects of a-synuclein overexpression in retinal degeneration: a 3D organoid approach". Paper presented in Cell Bio Virtual - ASCB/EMBO Online Meeting, 2021.
  4. "Modelling retinal degenerative mechanisms using patient-derived organoids". Paper presented in 3rd NMS Symposium, 2021.
  5. "Modeling retinal degeneration by hyperglycemia using 3D human organoids". Paper presented in Organoids With]Out[ Borders - Online Symposium, 2020.
  6. "Modeling retinal degeneration by hyperglycemia and oxidative stress using 3D human organoids". Paper presented in EMBO|EMBL Symposium: Organoids: Modeling Organ development and disease in 3D cell culture-virtual, 2020.
  7. Flores, Rita; Ana Luisa Basilio; Nuno Moura-Coelho; Margarida Marques; Luisa Vieira; Joana Cardigos; Ines Fragoeiro; et al. "Novel disease progression biomarkers in non-exudative age-related macular degeneration: an association study between drusen type and morphology and Fundus Autofluorescence". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  8. Miguel C. Seabra; M. Helena Cardoso; Michael Hall; A. Sofia Falcão; Cristina Escrevente; Pedro Antas; Gabriela V. Santos; Tenreiro, Sandra; Clare E. Futter. "Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  9. Tarafder, A. K.; Pereira, F. J.; Correia, M. S.; Barral, D. C.; Seabra, M. C.. "Mechanisms of melanin transfer from melanocytes and formation of a parasol in keratinocytes". 2016.
  10. MacLaren, Robert; Seabra, Miguel; Simunovic, Matthew; Downes, Susan; Xue, Kanmin; Holder, Graham; Lotery, Andrew; et al. "SUSTAINED IMPROVEMENT IN VISUAL ACUITY AFTER RETINAL GENE THERAPY FOR CHOROIDEREMIA". 2016.
  11. Seabra, Miguel. "Long term vision results following retinal gene therapy for choroideremia". Paper presented in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), 2016.
  12. Seabra, Miguel C.; Futter, Clare E.; Feleciano, Diogo A.; Tolmachova, Tanya. "Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium". Paper presented in ARVO Annual Meeting Abstract, 2015.
  13. Miguel C Seabra. "Rab27a GTPase modulates L-type Ca2+ channel function via direct interaction with the Ca(V)1.3 subunit". 2015.
  14. Miguel C Seabra. "Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles". Paper presented in ARVO Annual Meeting, 2015.
  15. Seabra, Miguel C.; Futter, Clare; Evans, Martin J.; Wavre-Shapton, Silene; Feleciano, Diogo A.; Tolmachova, Tanya. "AMD-compatible lysosomal changes in Rab38-deficient mouse model". Paper presented in ARVO Annual Meeting, 2014.
  16. Miguel C Seabra. "Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia". Paper presented in ARVO Annual Meeting, 2014.
  17. Futter, Clare; Seabra, Miguel C.; Tolmachova, Tanya; Meschede, Ingrid Porpino. "Mechanisms of photoreceptor degeneration in choroideremia". Paper presented in ARVO Annual Meeting, 2014.
  18. Tolmachova, Tanya; Seabra, Miguel; Hughes, Alun; Douglass, Angela; Coxon, Fraser. "RAB27 KNOCKOUT MICE HAVE LOW BONE DENSITY DUE TO DEFECTIVE OSTEOBLAST FUNCTION". 2012.
  19. Seabra, M. C.; Barral, D. C.; Pereira, F. J. C.; Iannone, L.; Tarafder, A. K.; Correia, M. S.. "Optimizing an endocytosis assay for the characterization of melanin uptake and processing by keratinocytes". Paper presented in Meeting of the Society for Pigment Cell Research, 2012.
  20. Miguel C Seabra. "Pathogenesis of diseases involving defects in Rab GTPase function and membrane traffic". Paper presented in 36th FEBS Congress of the Biochemistry for Tomorrows Medicine, 2011.
  21. Seabra, M. C.. "Rab GTPases in membrane traffic and disease". Paper presented in 33rd Annual Meeting of the German-Society-for-Cell-Biology/German Melanoma Research Network, 2010.
  22. Seabra, M. C.; Harbottle, R. P.; Tolmachova, T.; Tracey-White, D. C.; Wong, S. P.; Moosajee, M.; Ostad-Saffari, E.. "Persistent Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy". Paper presented in ARVO Annual Meeting, 2010.
  23. Gerke, V; Cutler, D.; Seabra, M.; Darchen, F.; Pulido, Rojo, I. "Myosin Va in regulated exocytosis of Weibel-Palade bodies". Paper presented in 33rd Annual Meeting of the German-Society-for-Cell-Biology/German Melanoma Research Network, 2010.
  24. Westbroek, W.; De Wever, O.; Gahl, W.; Seabra, M.; Bracke, M.; Cocquyt, V; Van Belle, S.; et al. "The Secretory Small GTPase Rab27B Regulates Invasive Tumor Growth and Metastasis through Extracellular Heat Shock Protein 90 alpha". Paper presented in 32nd Annual San Antonio Breast Cancer Symposium, 2009.
  25. Seabra, Miguel C.; Wavre, Silene T.; Lopes, Vanda S.; Futter, Clare E.. "Melanosome biogenesis, transport and function in retinal pigment epithelial cells". 2008.
  26. McKenna, C. E.; Rogers, M. J.; Seabra, M. C.; Ebetino, F. H.; Kashemirov, B. A.; Blazewska, K. M.; Marma, M. S.; et al. "Inhibition of Rab geranylgeranyl transferase and Rab prenylation by phosphonocarboxylate drugs". 2008.
  27. Rogers, MJ; Seabra, MC; Mules, EH; Taylor, A; Coxon, FP. "Osteoclasts from gunmetal mice are defective in Rab prenylation but not in bone resorption". Paper presented in nd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 2005.
  28. Coxon, FP; Rogers, MJ; Seabra, MC; Mules, EH; Taylor, A. "Osteoclasts derived from gunmetal mice are functional despite having defects in Rab prenylation". Paper presented in Annual Meeting of the Bone-and-Tooth-Society, 2005.
  29. Huxley, C; Seeliger, M; Tanimoto, N; Tonagel, F; Futter, C; Ramalho, JS; Abrink, M; et al. "Choroideremia mouse model generated by conditional Rep1 knock-out". Paper presented in ARVO Annual Meeting, 2005.
  30. Seabra, MC. "Rab GTPAses and the control of membrane traffic in bone cells". Paper presented in 2nd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society, 2005.
  31. Seabra, MC; Pereira, PC; Futter, CE; Lopes, VS; Ramalho, JS. "Intracellular trafficking of melanosomes in the retinal pigmented epithelium: mapping of interactions between Rab27a, Myrip and MyoVIIa". Paper presented in ARVO Annual Meeting, 2004.
  32. Rogers, MJ; Ebetino, FH; Seabra, M; Mules, E; Coxon, FP. "A phosphonocarboxylate analogue of risedronate (NE10790) inhibits Rab prenylation in osteoclasts in vivo and disrupts the membrane localization of Rab proteins in osteoclasts in vitro". 2002.
  33. Hopkins, CR; Collinson, LM; Authi, KS; Hume, AN; Mules, EH; Ramalho, JS; Barral, DC; Seabra, MC. "Function of Rab27 proteins and implications for disease". 2001.
  34. Seabra, MC; Strom, M; Gomes, AQ. "Importance of the prenylation motif on the membrane targeting of Rab GTPases". 2001.
  35. Rogers, MJ; Ebetino, FH; Seabra, MC; Nesbitt, SA; Larijani, B; Horton, MA; Marshall, D; et al. "A novel inhibitor of Rab prenylation causes basolateral membrane changes in osteoclasts and reduces their resorptive activity". 2001.
  36. Rogers, MJ; Ebetino, FH; Seabra, MC; Dunford, J; Larijani, B; Coxon, FP. "Discovery of a novel inhibitor of RAB geranylgeranyl transferase that inhibits bone resorption by selectively preventing prenylation of RAB proteins in osteoclasts". 2001.
  37. Shivdasani, RA; Swank, R; Seabra, M; Hartwig, J; Novak, E; Schwer, H; Italiano, J; Tiwari, S. "A role for the Rab sub-family of Ras GTPases in formation and release of blood platelets". 2000.
  38. Kingsmore, S; Swank, R; Seabra, M; Wallace, M; Mishra, V; Novak, E; Mules, E; Zhang, Q; Detter, JC. "Positional cloning of the, gunmetal mouse mutations". 1999.
  39. Seabra, MC; Huxley, C; Ramalho, JS. "The role of Rab27a in the pathogenesis of choroideremia: Generation of transgenic mice expressing dominant-negative mutants of Rab27a". 1999.
  40. Burke, S; Desnoyers, L; Anant, JS; Seabra, MC. "Molecular pathogenesis of choroideremia: Kinetics of REP:RAB binding". 1997.
  41. MacDonald, IM; Seabra, MC; Ho, YK; Mah, DY. "Biochemical and mutational analysis of the REP-1 gene in a family with choroideremia". 1997.
  42. Zhang, H.; Seabra, M. C.; Deisenhofer, J.. "Preliminary X-ray structure analysis of Rab geranylgeranyl transferase". 1996.
    10.1107/s0108767396094664
  43. Ye, J; Seabra, MC. "Nucleotide dependence of RAB geranylgeranylation: Detection of a soluble RAB GTPase activating protein (RAB GAP) that stimulates RAB-GTP geranylgeranylation". 1996.
  44. SEABRA, MC. "THE PATHOGENESIS OF CHOROIDEREMIA - IDENTIFICATION OF A REP-1 SPECIFIC RAB". 1995.
  45. GOLDSTEIN, JL; BROWN, MS; ARMSTRONG, SA; CREMERS, FPM; SEABRA, MC. "DEFICIENCY OF RAB GERANYLGERANYLATION IN CHOROIDEREMIA - ROLE OF RAB ESCORT PROTEINS". 1994.
  46. Miguel C Seabra. "CDNA CLONING AND EXPRESSION OF COMPONENT-A OF RAT RAB GERANYLGERANYL TRANSFERASE". 1993.
  47. Reiss, Y.; Seabra, M.C.; Brown, M.S.; Goldstein, J.L.. "p21ras farnesyltransferase: purification and properties of the enzyme.". 1992.
Conference poster
  1. "Keratinocyte-melanocyte cross-talk in melanin transfer". Paper presented in SINAL 2019, 2019.
Journal article
  1. Antas, Pedro; Carvalho, Cláudia; Cabral-Teixeira, Joaquim; de Lemos, Luísa; Seabra, MC. "Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases". Trends in Molecular Medicine (2023): http://dx.doi.org/10.1016/j.molmed.2023.11.009.
    Open access • Published • 10.1016/j.molmed.2023.11.009
  2. Cardoso, M. Helena; Hall, Michael J.; Burgoyne, Thomas; Fale, Pedro; Storm, Tina; Escrevente, Cristina; Antas, Pedro; Seabra, MC; Futter, Clare E.. Corresponding author: Futter, Clare E.. "Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells". Investigative Opthalmology & Visual Science 64 11 (2023): 10. http://dx.doi.org/10.1167/iovs.64.11.10.
    Open access • Published • 10.1167/iovs.64.11.10
  3. Flores, Rita; Fradinho, Ana C.; Pereira, Rita Serras; Mendes, Jorge M.; Seabra, MC; Tenreiro, Sandra; Carneiro, Ângela. Corresponding author: Flores, Rita. "Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression". Translational Vision Science & Technology 12 7 (2023): 22. http://dx.doi.org/10.1167/tvst.12.7.22.
    Open access • Published • 10.1167/tvst.12.7.22
  4. Bento-Lopes, Liliana; Cabaço, Luís C.; Charneca, João; Neto, Matilde V.; Seabra, MC; Barral, Duarte C.. Corresponding author: Barral, Duarte C.. "Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing". International Journal of Molecular Sciences 24 14 (2023): 11289. http://dx.doi.org/10.3390/ijms241411289.
    Published • 10.3390/ijms241411289
  5. Burrinha, Tatiana; Cunha, César; Hall, Michael J.; Lopes-da-Silva, Mafalda; Seabra, MC; Guimas Almeida, Cláudia. Corresponding author: Guimas Almeida, Cláudia. "Deacidification of endolysosomes by neuronal aging drives synapse loss". Traffic 24 8 (2023): 334-354. http://dx.doi.org/10.1111/tra.12889.
    Open access • Published • 10.1111/tra.12889
  6. Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M. Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.; et al. Corresponding author: Santos, Cláudia N.. "Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37561-2.
    Open access • Published • 10.1038/s41467-023-37561-2
  7. Dias, Sarah Batista; de Lemos, Luísa; Sousa, Luís; Bitoque, Diogo B.; Silva, Gabriela Araújo; Seabra, Miguel C.; Tenreiro, Sandra. "Age-Related Changes of the Synucleins Profile in the Mouse Retina". Biomolecules 13 1 (2023): 180. http://dx.doi.org/10.3390/biom13010180.
    Open access • Accepted • 10.3390/biom13010180
  8. Cabral, Diogo; Ramtohul, Prithvi; Kaden, Talia R.; Tenreiro, Sandra; Seabra, Miguel C.; Freund, K. Bailey. "Hyperpigmented epiretinal membrane in macular telangiectasia type 2: imaging characteristics and correlation with transretinal pigment migration". Eye (2022): http://dx.doi.org/10.1038/s41433-022-02260-7.
    In press • 10.1038/s41433-022-02260-7
  9. Cabaço, Luís C.; Bento-Lopes, Liliana; Neto, Matilde V.; Ferreira, Andreia; Staubli, Wanja B.L.; Ramalho, José S.; Seabra, Miguel C.; Barral, Duarte C.. "RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditioned Medium". JID Innovations 2 5 (2022): 100139. http://dx.doi.org/10.1016/j.xjidi.2022.100139.
    Open access • 10.1016/j.xjidi.2022.100139
  10. Cabral, Diogo; Fradinho, Ana C.; Pereira, Telmo; Ramakrishnan, Meera S.; Bacci, Tommaso; An, Dong; Tenreiro, Sandra; et al. Corresponding author: Freund, K. Bailey. "Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography". Translational Vision Science & Technology 11 6 (2022): 2. http://dx.doi.org/10.1167/tvst.11.6.2.
    Open access • Published • 10.1167/tvst.11.6.2
  11. Flores, Rita; Carneiro, Ângela; Neri, Guilherme; Fradinho, Ana C.; Quenderra, Bruno; Barata, Maria João; Tenreiro, Sandra; Seabra, MC. Corresponding author: Flores, Rita. "Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration". Diagnostics 12 5 (2022): 1290. http://dx.doi.org/10.3390/diagnostics12051290.
    Open access • Published • 10.3390/diagnostics12051290
  12. Moreiras, Hugo; Bento-Lopes, Liliana; Neto, Matilde V.; Escrevente, Cristina; Cabaço, Luís C.; Hall, Michael J.; Ramalho, José S.; Seabra, MC; Barral, Duarte C.. Corresponding author: Barral, Duarte C.. "Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization". Traffic 23 6 (2022): 331-345. http://dx.doi.org/10.1111/tra.12843.
    Published • 10.1111/tra.12843
  13. Barral, Duarte C.; Staiano, Leopoldo; Guimas Almeida, Cláudia; Cutler, Dan F.; Eden, Emily R.; Futter, Clare E.; Galione, Antony; et al. Corresponding author: Seabra, MC. "Current methods to analyze lysosome morphology, positioning, motility and function". Traffic 23 5 (2022): 238-269. http://dx.doi.org/10.1111/tra.12839.
    Open access • Published • 10.1111/tra.12839
  14. Hall, Michael J.; Lopes-Ventura, Sara; Neto, Matilde V.; Charneca, João; Zoio, Patricia; Seabra, MC; Oliva, Abel; Barral, Duarte C.. Corresponding author: Barral, Duarte C.. "Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer". Pigment Cell & Melanoma Research 35 4 (2022): 425-435. http://dx.doi.org/10.1111/pcmr.13039.
    Published • 10.1111/pcmr.13039
  15. Flores, Rita; Carneiro, Ângela; Tenreiro, Sandra; Seabra, Miguel C.. "Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration". Life 12 1 (2021): 36. http://dx.doi.org/10.3390/life12010036.
    Open access • 10.3390/life12010036
  16. Escrevente, Cristina; Falcão, Ana S.; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira, Inês S.; et al. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
    Open access • Published • 10.1167/iovs.62.9.39
  17. Flores, Rita; Carneiro, Ângela; Vieira, Miguel; Tenreiro, Sandra; Seabra, Miguel C.. "Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives". Ophthalmologica (2021): http://dx.doi.org/10.1159/000517520.
    Open access • Published • 10.1159/000517520
  18. Moreiras, Hugo; Seabra, Miguel C.; Barral, Duarte C.. "Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms". International Journal of Molecular Sciences 22 9 (2021): 4466. http://dx.doi.org/10.3390/ijms22094466.
    Open access • 10.3390/ijms22094466
  19. Meschede, Ingrid P.; Burgoyne, Thomas; Tolmachova, Tanya; Seabra, Miguel C.; Futter, Clare E.. "Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia". PLOS ONE 15 11 (2020): e0242284. http://dx.doi.org/10.1371/journal.pone.0242284.
    Published • 10.1371/journal.pone.0242284
  20. Flores, Rita; Carneiro, Angela; Serra, Joana; Gouveia, Nélia; Pereira, Telmo; Mendes, Jorge M.; Coelho, Pedro S.; Tenreiro, Sandra; Seabra, Miguel C.. "CORRELATION STUDY BETWEEN DRUSEN MORPHOLOGY AND FUNDUS AUTOFLUORESCENCE". Retina Publish Ah (2020): http://dx.doi.org/10.1097/iae.0000000000002881.
    Published • 10.1097/iae.0000000000002881
  21. Meschede, Ingrid P.; Ovenden, Nicholas C.; Seabra, Miguel C.; Futter, Clare E.; Votruba, Marcela; Cheetham, Michael E.; Burgoyne, Thomas. "Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1". Proceedings of the National Academy of Sciences 117 27 (2020): 15684-15693. http://dx.doi.org/10.1073/pnas.2000304117.
    Open access • Published • 10.1073/pnas.2000304117
  22. Gross, Tilman; Wack, Gesine; Syhr, Katharina M. J.; Tolmachova, Tanya; Seabra, Miguel C.; Geisslinger, Gerd; Niederberger, Ellen; Schmidtko, Achim; Kallenborn-Gerhardt, Wiebke. "Rab27a Contributes to the Processing of Inflammatory Pain in Mice". Cells 9 6 (2020): 1488. http://dx.doi.org/10.3390/cells9061488.
    10.3390/cells9061488
  23. Miguel C. Seabra. "Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production.". EMBO reports (2020): https://europepmc.org/articles/PMC7132182.
    10.15252/embr.201948925
  24. Miguel C. Seabra. "The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes.". Pigment cell & melanoma research (2019): https://doi.org/10.1111/pcmr.12840.
    10.1111/pcmr.12840
  25. Hayes, Matthew J.; Burgoyne, Thomas; Wavre-Shapton, Silene T.; Tolmachova, Tanya; Seabra, Miguel C.; Futter, Clare E.. "Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease". Investigative Opthalmology & Visual Science 60 7 (2019): 2515. http://dx.doi.org/10.1167/iovs.19-26784.
    Open access • Published • 10.1167/iovs.19-26784
  26. Miguel C. Seabra. "Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease.". Investigative ophthalmology & visual science (2019): https://europepmc.org/articles/PMC6564051.
    10.1167/iovs.19-26784
  27. Storck, Elisabeth M.; Morales-Sanfrutos, Julia; Serwa, Remigiusz A.; Panyain, Nattawadee; Lanyon-Hogg, Thomas; Tolmachova, Tanya; Ventimiglia, Leandro N.; et al. "Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics". Nature Chemistry 11 6 (2019): 552-561. http://dx.doi.org/10.1038/s41557-019-0237-6.
    Open access • 10.1038/s41557-019-0237-6
  28. Sanzà, Paolo; Evans, Richard D.; Briggs, Deborah A.; Cantero, Marta; Montoliu, Lluis; Patel, Shyamal; Sviderskaya, Elena V.; et al. "Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a". Journal of Cell Science 132 9 (2019): jcs212035. http://dx.doi.org/10.1242/jcs.212035.
    Open access • Published • 10.1242/jcs.212035
  29. Moreiras, Hugo; Lopes-da-Silva, Mafalda; Seabra, Miguel C.; Barral, Duarte C.. "Melanin processing by keratinocytes: A non-microbial type of host-pathogen interaction?". Traffic 20 4 (2019): 301-304. http://dx.doi.org/10.1111/tra.12638.
    Open access • Published • 10.1111/tra.12638
  30. Hume, Alistair N.; Seabra, Miguel C.; Figueiredo, Ana C.; Itzen, Aymelt; Sviderskaya, Elena V.; Patel, Shyamal; Montoliu, Lluis; et al. "Nucleotide exchange factor Rab3GEP requires DENN and non- DENN elements for activation and targeting of Rab27a". Journal of Cell Science (2019): https://publons.com/publon/21577431/.
    10.1242/JCS.212035
  31. Xue, Kanmin; Jolly, Jasleen K; Barnard, Alun R.; Rudenko, Anna; Salvetti, Anna P.; Patrício, Maria I.; Edwards, Thomas L.; et al. "Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia". Nature Medicine 24 10 (2018): 1507-1512. http://dx.doi.org/10.1038/s41591-018-0185-5.
    Open access • 10.1038/s41591-018-0185-5
  32. Dimopoulos, Ioannis S.; Hoang, Stephanie C.; Radziwon, Alina; Binczyk, Natalia M.; Seabra, Miguel C.; MacLaren, Robert E.; Somani, Rizwan; Tennant, Matthew T.S.; MacDonald, Ian M.. "Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience". American Journal of Ophthalmology 193 (2018): 130-142. http://dx.doi.org/10.1016/j.ajo.2018.06.011.
    Open access • 10.1016/j.ajo.2018.06.011
  33. Seixas, Elsa; Escrevente, Cristina; Seabra, Miguel C.; Barral, Duarte C.. "Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-31171-5.
    Open access • 10.1038/s41598-018-31171-5
  34. Correia, Maria S.; Moreiras, Hugo; Pereira, Francisco J.C.; Neto, Matilde V.; Festas, Tiago C.; Tarafder, Abul K.; Ramalho, José S.; Seabra, Miguel C.; Barral, Duarte C.. "Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments". Journal of Investigative Dermatology 138 3 (2018): 637-646. http://dx.doi.org/10.1016/j.jid.2017.09.042.
    Published • 10.1016/j.jid.2017.09.042
  35. Seabra, Miguel C.; Jolly, Jasleen K.; Webster, Andrew; Black, Graeme; Lotery, Andrew; Downes, Susan; Edwards, Thomas L.; et al. "Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial". Investigative Ophthalmology & Visual Science (2018): https://publons.com/publon/21577433/.
  36. Alexander, Margaret; Ramstead, Andrew G.; Bauer, Kaylyn M.; Lee, Soh-Hyun; Runtsch, Marah C.; Wallace, Jared; Huffaker, Thomas B.; et al. "Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli". The Journal of Immunology 199 10 (2017): 3559-3570. http://dx.doi.org/10.4049/jimmunol.1700904.
    Open access • Published • 10.4049/jimmunol.1700904
  37. Edwards, Thomas L.; Jolly, Jasleen K.; Groppe, Markus; Barnard, Alun R.; Cottriall, Charles L.; Tolmachova, Tanya; Black, Graeme C.; et al. "Visual Acuity after Retinal Gene Therapy for Choroideremia". New England Journal of Medicine 374 20 (2016): 1996-1998. http://dx.doi.org/10.1056/nejmc1509501.
    Open access • 10.1056/nejmc1509501
  38. Wankel, Bret; Ouyang, Jiangyong; Guo, Xuemei; Hadjiolova, Krassimira; Miller, Jeremy; Liao, Yi; Tham, Daniel Kai Long; et al. "Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells". Molecular Biology of the Cell 27 10 (2016): 1621-1634. http://dx.doi.org/10.1091/mbc.e15-04-0230.
    Open access • Published • 10.1091/mbc.e15-04-0230
  39. Seabra, Miguel; Webster, Andrew; Lotery, Andrew J.; Black, Graeme C. M.; Holder, Graham E.; Downes, Susan; Xue, Kanmin; et al. "Long term vision results following retinal gene therapy for choroideremia". Investigative Ophthalmology & Visual Science (2016): https://publons.com/publon/21577439/.
  40. "Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells". Molecular biology of the cell (2016): http://europepmc.org/articles/PMC4865319.
    10.1091/mbc.E15-04-0230
  41. "Correction: A Role for Na+,K+-ATPase a1 in Regulating Rab27a Localisation on Melanosomes". PloS one (2016): http://europepmc.org/articles/PMC4740420.
    10.1371/journal.pone.0148719
  42. Burgoyne, Thomas; Meschede, Ingrid P.; Burden, Jemima J.; Bailly, Maryse; Seabra, Miguel C.; Futter, Clare E.. "Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment". Proceedings of the National Academy of Sciences 112 52 (2015): 15922-15927. http://dx.doi.org/10.1073/pnas.1509285113.
    Open access • Published • 10.1073/pnas.1509285113
  43. Thieleke-Matos, Carolina; Lopes da Silva, Mafalda; Cabrita-Santos, Laura; Portal, Martim D.; Rodrigues, Inês P.; Zuzarte-Luis, Vanessa; Ramalho, José S.; et al. "Host cell autophagy contributes to Plasmodium liver development". Cellular Microbiology 18 3 (2015): 437-450. http://dx.doi.org/10.1111/cmi.12524.
    Open access • 10.1111/cmi.12524
  44. Reichhart, Nadine; Markowski, Magdalena; Ishiyama, Shimpei; Wagner, Andrea; Crespo-Garcia, Sergio; Schorb, Talitha; Ramalho, José S.; et al. "Rab27a GTPase modulates L-type Ca 2+ channel function via interaction with the II–III linker of Ca V 1.3 subunit". Cellular Signalling 27 11 (2015): 2231-2240. http://dx.doi.org/10.1016/j.cellsig.2015.07.023.
    Published • 10.1016/j.cellsig.2015.07.023
  45. Wavre-Shapton, Silène T.; Calvi, Alessandra A.; Turmaine, Mark; Seabra, Miguel C.; Cutler, Daniel F.; Futter, Clare E.; Mitchison, Hannah M.. "Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium ofCln3¿ex1-6mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease)". Human Molecular Genetics (2015): ddv406. http://dx.doi.org/10.1093/hmg/ddv406.
    10.1093/hmg/ddv406
  46. Alexander, Margaret; Hu, Ruozhen; Runtsch, Marah C.; Kagele, Dominique A.; Mosbruger, Timothy L.; Tolmachova, Tanya; Seabra, Miguel C.; et al. "Exosome-delivered microRNAs modulate the inflammatory response to endotoxin". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms8321.
    Open access • 10.1038/ncomms8321
  47. Alexander, Margaret; Hu, Ruozhen; Runtsch, Marah C.; Kagele, Dominique A.; Mosbruger, Timothy L.; Tolmachova, Tanya; Seabra, Miguel C.; et al. "Exosome-delivered microRNAs modulate the inflammatory response to endotoxin". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms8321.
    Open access • Published • 10.1038/ncomms8321
  48. Walker, B.; Schmid, E.; Russo, A.; Schmidt, E.-M.; Burk, O.; Münzer, P.; Velic, A.; et al. "Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion". Journal of Thrombosis and Haemostasis 13 7 (2015): 1325-1334. http://dx.doi.org/10.1111/jth.12998.
    Open access • Published • 10.1111/jth.12998
  49. Burgoyne, T.; O'Connor, M. N.; Seabra, M. C.; Cutler, D. F.; Futter, C. E.. "Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL". Journal of Cell Science 128 7 (2015): 1400-1407. http://dx.doi.org/10.1242/jcs.164400.
    Open access • Published • 10.1242/jcs.164400
  50. Singh, Rajesh K; Furze, Rebecca C; Birrell, Mark A; Rankin, Sara M; Hume, Alistair N; Seabra, Miguel C. "A role for Rab27 in neutrophil chemotaxis and lung recruitment". BMC Cell Biology 15 1 (2014): http://dx.doi.org/10.1186/s12860-014-0039-z.
    Open access • Published • 10.1186/s12860-014-0039-z
  51. Hume, Alistair N.; Seabra, Miguel C.. "Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise". Pigment Cell & Melanoma Research 27 6 (2014): 1012-1013. http://dx.doi.org/10.1111/pcmr.12310.
    Published • 10.1111/pcmr.12310
  52. Okoye, Isobel S.; Coomes, Stephanie M.; Pelly, Victoria S.; Czieso, Stephanie; Papayannopoulos, Venizelos; Tolmachova, Tanya; Seabra, Miguel C.; Wilson, Mark S.. "MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells". Immunity 41 3 (2014): 503. http://dx.doi.org/10.1016/j.immuni.2014.08.008.
    Open access • 10.1016/j.immuni.2014.08.008
  53. Thieleke-Matos, Carolina; da Silva, Mafalda Lopes; Cabrita-Santos, Laura; Pires, Cristiana F.; Ramalho, José S.; Ikonomov, Ognian; Seixas, Elsa; et al. "Host PI(3,5)P2Activity Is Required forPlasmodium bergheiGrowth During Liver Stage Infection". Traffic 15 10 (2014): 1066-1082. http://dx.doi.org/10.1111/tra.12190.
    Open access • Published • 10.1111/tra.12190
  54. Wavre-Shapton, S. T.; Meschede, I. P.; Seabra, M. C.; Futter, C. E.. "Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium". Journal of Cell Science 127 17 (2014): 3852-3861. http://dx.doi.org/10.1242/jcs.154757.
    Open access • Published • 10.1242/jcs.154757
  55. Booth, Antonia E. G.; Tarafder, Abul K.; Hume, Alistair N.; Recchi, Chiara; Seabra, Miguel C.. "A Role for Na+,K+-ATPase a1 in Regulating Rab27a Localisation on Melanosomes". PLoS ONE 9 7 (2014): e102851. http://dx.doi.org/10.1371/journal.pone.0102851.
    Open access • Published • 10.1371/journal.pone.0102851
  56. Tarafder, Abul K.; Bolasco, Giulia; Correia, Maria S.; Pereira, Francisco J.C.; Iannone, Lucio; Hume, Alistair N.; Kirkpatrick, Niall; et al. "Rab11b Mediates Melanin Transfer between Donor Melanocytes and Acceptor Keratinocytes via Coupled Exo/Endocytosis". Journal of Investigative Dermatology 134 4 (2014): 1056-1066. http://dx.doi.org/10.1038/jid.2013.432.
    Published • 10.1038/jid.2013.432
  57. MacLaren, Robert E; Groppe, Markus; Barnard, Alun R; Cottriall, Charles L; Tolmachova, Tanya; Seymour, Len; Clark, K Reed; et al. "Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial". The Lancet 383 9923 (2014): 1129-1137. http://dx.doi.org/10.1016/s0140-6736(13)62117-0.
    Open access • 10.1016/s0140-6736(13)62117-0
  58. Seabra, Miguel C.; Webster, Andrew; Downes, Susan M.; Lotery, Andrew; Black, Graeme C.; Cremers, Frans P.; Tolmachova, Tanya; et al. "Improved visual function in patients with choroideremia undergoing subretinal gene therapy". Investigative Ophthalmology & Visual Science (2014): https://publons.com/publon/21577452/.
  59. Black, A.; Vasireddy, V.; Chung, D.C.; Maguire, A.M.; Gaddameedi, R.; Tolmachova, T.; Seabra, M.; Bennett, J.. "Adeno-associated virus 8-mediated gene therapy for choroideremia: Preclinical studies in in vitro and in vivo models". Journal of Gene Medicine 16 5-6 (2014): 122-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904540483&partnerID=MN8TOARS.
    10.1002/jgm.2768
  60. Burgoyne, T.; Jolly, R.; Martin-Martin, B.; Seabra, M.C.; Piccirillo, R.; Schiaffino, M.V.; Futter, C.E.. "Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes [J. Cell Sci. 126, 5143-5152]". Journal of Cell Science 127 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84894098374&partnerID=MN8TOARS.
    10.1242/jcs.148072
  61. Seabra, Miguel. "Portugal's research funding is secure". Nature (2014): https://publons.com/publon/21577447/.
    10.1038/507306B
  62. Burgoyne, T.; Jolly, R.; Martin-Martin, B.; Seabra, M. C.; Piccirillo, R.; Schiaffino, M. V.; Futter, C. E.. "Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes". Journal of Cell Science 126 22 (2013): 5143-5152. http://dx.doi.org/10.1242/jcs.128561.
    Open access • Published • 10.1242/jcs.128561
  63. Kim, John Dongil; Willetts, Lian; Ochkur, Sergei; Srivastava, Nutan; Hamburg, Rudolf; Shayeganpour, Anooshirvan; Seabra, Miguel C.; et al. "An essential role for Rab27a GTPase in eosinophil exocytosis". Journal of Leukocyte Biology 94 6 (2013): 1265-1274. http://dx.doi.org/10.1189/jlb.0812431.
    Open access • 10.1189/jlb.0812431
  64. Moosajee, Mariya; Ramsden, Simon C; Black, Graeme CM; Seabra, Miguel C; Webster, Andrew R. "Clinical utility gene card for: Choroideremia". European Journal of Human Genetics 22 4 (2013): 572-572. http://dx.doi.org/10.1038/ejhg.2013.183.
    Open access • 10.1038/ejhg.2013.183
  65. Tolmachova, Tanya; Tolmachov, Oleg E.; Barnard, Alun R.; de Silva, Samantha R.; Lipinski, Daniel M.; Walker, Nathan J.; MacLaren, Robert E.; Seabra, Miguel C.. "Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo". Journal of Molecular Medicine 91 7 (2013): 825-837. http://dx.doi.org/10.1007/s00109-013-1006-4.
    Open access • 10.1007/s00109-013-1006-4
  66. Kirsten, Marie L.; Baron, Rudi A.; Seabra, Miguel C.; Ces, Oscar. "Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy". Molecular Membrane Biology 30 4 (2013): 303-314. http://dx.doi.org/10.3109/09687688.2013.818725.
    Open access • 10.3109/09687688.2013.818725
  67. Seixas, Elsa; Barros, Mafalda; Seabra, Miguel C.; Barral, Duarte C.. "Rab and Arf Proteins in Genetic Diseases". Traffic 14 8 (2013): 871-885. http://dx.doi.org/10.1111/tra.12072.
    Open access • Published • 10.1111/tra.12072
  68. Wavre-Shapton, Silène T.; Tolmachova, Tanya; da Silva, Mafalda Lopes; Futter, Clare E.; Seabra, Miguel C.. "Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium". PLoS ONE 8 2 (2013): e57769. http://dx.doi.org/10.1371/journal.pone.0057769.
    Open access • Published • 10.1371/journal.pone.0057769
  69. Miguel C Seabra. "Gene Replacement Therapy for Choroideremia". Molecular Therapy (2013): https://publons.com/publon/21577458/.
  70. "Correction: Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium". PloS one (2013): http://europepmc.org/articles/PMC3654017.
    10.1371/annotation/83a88285-e6a0-41fb-ae67-4315c21e5090
  71. Singh, Rajesh K.; Mizuno, Koichi; Wasmeier, Christina; Wavre-Shapton, Silene T.; Recchi, Chiara; Catz, Sergio D.; Futter, Clare; et al. "Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion". FEBS Journal (2012): n/a-n/a. http://dx.doi.org/10.1111/febs.12081.
    Open access • 10.1111/febs.12081
  72. Bobrie, A.; Krumeich, S.; Reyal, F.; Recchi, C.; Moita, L. F.; Seabra, M. C.; Ostrowski, M.; Thery, C.. "Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression". Cancer Research 72 19 (2012): 4920-4930. http://dx.doi.org/10.1158/0008-5472.can-12-0925.
    Open access • 10.1158/0008-5472.can-12-0925
  73. Lopes da Silva, Mafalda; Thieleke-Matos, Carolina; Cabrita-Santos, Laura; Ramalho, José S.; Wavre-Shapton, Silène T.; Futter, Clare E.; Barral, Duarte C.; Seabra, Miguel C.. "The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver Stage Development". Traffic 13 10 (2012): 1351-1363. http://dx.doi.org/10.1111/j.1600-0854.2012.01398.x.
    Open access • Published • 10.1111/j.1600-0854.2012.01398.x
  74. Seixas, Elsa; Ramalho, José S.; Mota, Luís J.; Barral, Duarte C.; Seabra, Miguel C.. "Bacteria and Protozoa Differentially Modulate the Expression of Rab Proteins". PLoS ONE 7 7 (2012): e39858. http://dx.doi.org/10.1371/journal.pone.0039858.
    Open access • Published • 10.1371/journal.pone.0039858
  75. Tolmachova, Tanya; Tolmachov, Oleg E.; Wavre-Shapton, Silene T.; Tracey-White, Dhani; Futter, Clare E.; Seabra, Miguel C.. "CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice". The Journal of Gene Medicine 14 3 (2012): 158-168. http://dx.doi.org/10.1002/jgm.1652.
    Published • 10.1002/jgm.1652
  76. Seabra, Miguel; Booth AE; Seabra MC; Hume AN. "Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs". Biochemical Society transactions (2012): https://doi.org/10.1042/BST20120200.
    10.1042/bst20120200
  77. Seabra, Miguel. "Novel functions for Rab GTPases in multiple aspects of tumour progression". Biochemical Society transactions (2012): http://europepmc.org/articles/PMC3554041.
    10.1042/BST20120199
  78. Hendrix, An; Lambein, Kathleen; Westbroek, Wendy; Seabra, Miguel C.; Cocquyt, Veronique; Pauwels, Patrick; Bracke, Marc; Gespach, Christian; Wever, Olivier De. "An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue". The International Journal of Developmental Biology 56 5 (2012): 363-368. http://dx.doi.org/10.1387/ijdb.120008ah.
    Open access • 10.1387/ijdb.120008ah
  79. Miguel C Seabra. "Molecular characterization of melanin transfer from donor melanocytes to recipient keratinocytes". Molecular Biology of the Cell (2012): https://publons.com/publon/21577462/.
  80. Miguel C Seabra. "The Development of Non-Viral Vectors for Choroideremia". Molecular Therapy (2012): https://publons.com/publon/21577466/.
  81. Miguel C Seabra. "Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment". Journal of Cell Science (2012): https://publons.com/publon/21577467/.
    10.1242/JCS.100438
  82. Seabra, Miguel C.; MacLaren, Robert E.; During, Matthew J.; Groppe, Markus; Barnard, Alun R.; Tolmachov, Oleg E.; Tolmachova, Tanya. "AAV2/2-CBA-REP1 Vector with WPRE Provides Functional Expression of the Transgene in Choroideremia Mouse Knock-Out and Patient Cells". Molecular Therapy (2012): https://publons.com/publon/21577465/.
  83. Diekmann, Yoan; Seixas, Elsa; Gouw, Marc; Tavares-Cadete, Filipe; Seabra, Miguel C.; Pereira-Leal, José B.. "Thousands of Rab GTPases for the Cell Biologist". PLoS Computational Biology 7 10 (2011): e1002217. http://dx.doi.org/10.1371/journal.pcbi.1002217.
    Open access • Published • 10.1371/journal.pcbi.1002217
  84. Hume, Alistair N.; Seabra, Miguel C.. "Melanosomes on the move: a model to understand organelle dynamics". Biochemical Society Transactions 39 5 (2011): 1191-1196. http://dx.doi.org/10.1042/bst0391191.
    Published • 10.1042/bst0391191
  85. Rojo Pulido, Inés; Nightingale, Thomas D.; Darchen, François; Seabra, Miguel C.; Cutler, Daniel F.; Gerke, Volker. "Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von-Willebrand Factor Release from Endothelial Cells". Traffic 12 10 (2011): 1371-1382. http://dx.doi.org/10.1111/j.1600-0854.2011.01248.x.
    Open access • Published • 10.1111/j.1600-0854.2011.01248.x
  86. Chiang, Lilian; Ngo, Julie; Schechter, Joel E.; Karvar, Serhan; Tolmachova, Tanya; Seabra, Miguel C.; Hume, Alistair N.; Hamm-Alvarez, Sarah F.. "Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland". American Journal of Physiology-Cell Physiology 301 2 (2011): C507-C521. http://dx.doi.org/10.1152/ajpcell.00355.2010.
    Open access • Published • 10.1152/ajpcell.00355.2010
  87. Tarafder, Abul K.; Wasmeier, Christina; Figueiredo, Ana C.; Booth, Antonia E. G.; Orihara, Asumi; Ramalho, Jose S.; Hume, Alistair N.; Seabra, Miguel C.. "Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding". Traffic 12 8 (2011): 1056-1066. http://dx.doi.org/10.1111/j.1600-0854.2011.01216.x.
    Open access • Published • 10.1111/j.1600-0854.2011.01216.x
  88. Taylor, Adam; Mules, Emilie H.; Seabra, Miguel C.; Helfrich, Miep H.; Rogers, Michael J.; Coxon, Fraser P.. "Impaired prenylation of Rab GTPases in thegunmetalmouse causes defects in bone cell function". Small GTPases 2 3 (2011): 131-142. http://dx.doi.org/10.4161/sgtp.2.3.16488.
    Open access • 10.4161/sgtp.2.3.16488
  89. Bolasco, Giulia; Tracey-White, Dhani C.; Tolmachova, Tanya; Thorley, Andrew J.; Tetley, Teresa D.; Seabra, Miguel C.; Hume, Alistair N.. "Loss of Rab27 function results in abnormal lung epithelium structure in mice". American Journal of Physiology-Cell Physiology 300 3 (2011): C466-C476. http://dx.doi.org/10.1152/ajpcell.00446.2010.
    Open access • 10.1152/ajpcell.00446.2010
  90. Seabra, Miguel. "Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland". American journal of physiology. Cell physiology (2011): http://europepmc.org/articles/PMC3154548.
    10.1152/ajpcell.00355.2010
  91. Seabra, Miguel. "The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates". Bone (2011): https://doi.org/10.1016/j.bone.2011.03.686.
    10.1016/j.bone.2011.03.686
  92. Michael A. Ferenczi. "Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex Transport Function". Traffic (2011): https://publons.com/publon/10397620/.
    10.1111/J.1600-0854.2011.01283.X
  93. McKenna, Charles E.; Ebetino, Frank H.; Seabra, Miguel C.; Rogers, Michael J.; Baron, Rudi; Stewart, Charlotte A.; Coxon, Fraser P.; et al. "Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors". European Journal of Medicinal Chemistry (2011): https://publons.com/publon/2169969/.
    10.1016/J.EJMECH.2011.04.063
  94. Nightingale, T.D.; Pattni, K.; Hume, A.N.; Seabra, M.C.; Cutler, D.F.. "Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. (Blood (2009) 113, 20, (5010-5018))". Blood 117 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953124444&partnerID=MN8TOARS.
    10.1182/blood-2011-01-329136
  95. Anderson, Karen E.; Chessa, Tamara A. M.; Davidson, Keith; Henderson, Robert B.; Walker, Simon; Tolmachova, Tanya; Grys, Katarzyna; et al. "PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils". Blood 116 23 (2010): 4978-4989. http://dx.doi.org/10.1182/blood-2010-03-275602.
    Open access • Published • 10.1182/blood-2010-03-275602
  96. Tolmachova, Tanya; Wavre-Shapton, Silene T.; Barnard, Alun R.; MacLaren, Robert E.; Futter, Clare E.; Seabra, Miguel C.. "Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia". Investigative Opthalmology & Visual Science 51 10 (2010): 4913. http://dx.doi.org/10.1167/iovs.09-4892.
    Open access • Published • 10.1167/iovs.09-4892
  97. Hendrix A; Braems G; Bracke M; Seabra M; Gahl W; De Wever O; Westbroek W; et al. "The secretory small GTPase Rab27B as a marker for breast cancer progression.". Oncotarget (2010): http://europepmc.org/abstract/med/21304180.
    Open access • 10.18632/ONCOTARGET.100809
  98. Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van den Broecke, Rudy; Lambert, Jo; et al. "Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis". JNCI: Journal of the National Cancer Institute 102 12 (2010): 866-880. http://dx.doi.org/10.1093/jnci/djq153.
    Open access • 10.1093/jnci/djq153
  99. Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van den Broecke, Rudy; Lambert, Jo; et al. "Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis". JNCI: Journal of the National Cancer Institute 102 12 (2010): 866-880. http://dx.doi.org/10.1093/jnci/djq153.
    Open access • Published • 10.1093/jnci/djq153
  100. Ali, Bassam R.; Nouvel, Ian; Leung, Ka Fai; Hume, Alistair N.; Seabra, Miguel C.. "A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases". Biochemical and Biophysical Research Communications 397 1 (2010): 34-41. http://dx.doi.org/10.1016/j.bbrc.2010.05.045.
    Open access • Published • 10.1016/j.bbrc.2010.05.045
  101. McKenna, Charles E.; Kashemirov, Boris A.; Blaz¿ewska, Katarzyna M.; Mallard-Favier, Isabelle; Stewart, Charlotte A.; Rojas, Javier; Lundy, Mark W.; et al. "Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid". Journal of Medicinal Chemistry 53 9 (2010): 3454-3464. http://dx.doi.org/10.1021/jm900232u.
    Open access • Published • 10.1021/jm900232u
  102. Berry, Alexandra F. H.; Heal, William P.; Tarafder, Abul K.; Tolmachova, Tanya; Baron, Rudi A.; Seabra, Miguel C.; Tate, Edward W.. "Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry". ChemBioChem 11 6 (2010): 771-773. http://dx.doi.org/10.1002/cbic.201000087.
    10.1002/cbic.201000087
  103. Frasa, Marieke A.M.; Maximiano, Filipe C.; Smolarczyk, Kasia; Francis, Richard E.; Betson, Martha E.; Lozano, Encarnacion; Goldenring, James; et al. "Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation". Current Biology 20 3 (2010): 198-208. http://dx.doi.org/10.1016/j.cub.2009.12.053.
    Open access • 10.1016/j.cub.2009.12.053
  104. Miguel C Seabra. "Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms". Traffic (2010): https://publons.com/publon/21577478/.
    10.1111/J.1600-0854.2009.01029.X
  105. Ostrowski, Matias; Carmo, Nuno B.; Krumeich, Sophie; Fanget, Isabelle; Raposo, Graça; Savina, Ariel; Moita, Catarina F.; et al. "Rab27a and Rab27b control different steps of the exosome secretion pathway". Nature Cell Biology 12 1 (2009): 19-30. http://dx.doi.org/10.1038/ncb2000.
    Open access • Published • 10.1038/ncb2000
  106. Ramalho, José S.; Lopes, Vanda S.; Tarafder, Abul K.; Seabra, Miguel C.; Hume, Alistair N.. "Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport". Pigment Cell & Melanoma Research 22 4 (2009): 461-473. http://dx.doi.org/10.1111/j.1755-148x.2009.00567.x.
    10.1111/j.1755-148x.2009.00567.x
  107. Moosajee, Mariya; Tulloch, Merrin; Baron, Rudi A.; Gregory-Evans, Cheryl Y.; Pereira-Leal, Jose´ B.; Seabra, Miguel C.. "Single choroideremia Gene in Non mammalian Vertebrates Explains Early Embryonic Lethality of the Zebrafish Model of Choroideremia". Investigative Opthalmology & Visual Science 50 6 (2009): 3009. http://dx.doi.org/10.1167/iovs.08-2755.
    Published • 10.1167/iovs.08-2755
  108. Nightingale, Thomas D.; Pattni, Krupa; Hume, Alistair N.; Seabra, Miguel C.; Cutler, Daniel F.. "Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells". Blood 113 20 (2009): 5010-5018. http://dx.doi.org/10.1182/blood-2008-09-181206.
    Open access • Published • 10.1182/blood-2008-09-181206
  109. "Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase". The Journal of biological chemistry (2009): http://europepmc.org/articles/PMC2652301.
    10.1074/jbc.M806952200
  110. Baron, Rudi A.; Tavaré, Richard; Figueiredo, Ana C.; Blazewska, Katarzyna M.; Kashemirov, Boris A.; McKenna, Charles E.; Ebetino, Frank H.; et al. "Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase". Journal of Biological Chemistry 284 11 (2008): 6861-6868. http://dx.doi.org/10.1074/jbc.m806952200.
    Open access • Published • 10.1074/jbc.m806952200
  111. Wasmeier, C.; Hume, A. N.; Bolasco, G.; Seabra, M. C.. "Melanosomes at a glance". Journal of Cell Science 121 24 (2008): 3995-3999. http://dx.doi.org/10.1242/jcs.040667.
    Open access • Published • 10.1242/jcs.040667
  112. Hume, A. N.; Buttgereit, J.; Al-Awadhi, A. M.; Al-Suwaidi, S. S.; John, A.; Bader, M.; Seabra, M. C.; Al-Gazali, L.; Ali, B. R.. "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux". Human Molecular Genetics 18 2 (2008): 267-277. http://dx.doi.org/10.1093/hmg/ddn354.
    Open access • Published • 10.1093/hmg/ddn354
  113. Baron, Rudi A.; Seabra, Miguel C.. "Rab geranylgeranylation occurs preferentially via the pre-formed REP–RGGT complex and is regulated by geranylgeranyl pyrophosphate". Biochemical Journal 415 1 (2008): 67-75. http://dx.doi.org/10.1042/bj20080662.
    Published • 10.1042/bj20080662
  114. Moosajee, M.; Gregory-Evans, K.; Ellis, C. D.; Seabra, M. C.; Gregory-Evans, C. Y.. "Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease". Human Molecular Genetics 17 24 (2008): 3987-4000. http://dx.doi.org/10.1093/hmg/ddn302.
    Published • 10.1093/hmg/ddn302
  115. Figueiredo, Ana C.; Wasmeier, Christina; Tarafder, Abul K.; Ramalho, José S.; Baron, Rudi A.; Seabra, Miguel C.. "Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes". Journal of Biological Chemistry 283 34 (2008): 23209-23216. http://dx.doi.org/10.1074/jbc.m804134200.
    Open access • Published • 10.1074/jbc.m804134200
  116. "Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes". The Journal of biological chemistry (2008): http://europepmc.org/articles/PMC2516999.
    10.1074/jbc.M804134200
  117. Coxon, Fraser P.; Rogers, Michael J.; Ebetino, Frank H.; Kashemirov, Boris A.; McKenna, Charles E.; Blazewska, Katarzyna M.; Seabra, Miguel C.; et al. "Characterisation of the inhibition of rab prenylation by phosphonocarboxylates". Bone (2008): https://publons.com/publon/11292902/.
    10.1016/J.BONE.2007.12.167
  118. Lopes, Vanda S.; Wasmeier, Christina; Seabra, Miguel C.; Futter, Clare E.. "Melanosome Maturation Defect in Rab38-deficient Retinal Pigment Epithelium Results in Instability of Immature Melanosomes during Transient Melanogenesis". Molecular Biology of the Cell 18 10 (2007): 3914-3927. http://dx.doi.org/10.1091/mbc.e07-03-0268.
    Open access • Published • 10.1091/mbc.e07-03-0268
  119. Hume, A. N.; Ushakov, D. S.; Tarafder, A. K.; Ferenczi, M. A.; Seabra, M. C.. "Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes". Journal of Cell Science 120 17 (2007): 3111-3122. http://dx.doi.org/10.1242/jcs.010207.
    Open access • Published • 10.1242/jcs.010207
  120. Mizuno, Kouichi; Tolmachova, Tanya; Ushakov, Dmitry S.; Romao, Maryse; Åbrink, Magnus; Ferenczi, Michael A.; Raposo, Graça; Seabra, Miguel C.. "Rab27b Regulates Mast Cell Granule Dynamics and Secretion". Traffic 8 7 (2007): 883-892. http://dx.doi.org/10.1111/j.1600-0854.2007.00571.x.
    Open access • Published • 10.1111/j.1600-0854.2007.00571.x
  121. Lopes, Vanda S.; Ramalho, José S.; Owen, Dylan M.; Karl, Mike O.; Strauss, Olaf; Futter, Clare E.; Seabra, Miguel C.. "The Ternary Rab27a-Myrip-Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium". Traffic 8 5 (2007): 486-499. http://dx.doi.org/10.1111/j.1600-0854.2007.00548.x.
    Open access • Published • 10.1111/j.1600-0854.2007.00548.x
  122. Tolmachova, T.; Abrink, M.; Futter, C. E.; Authi, K. S.; Seabra, M. C.. "Rab27b regulates number and secretion of platelet dense granules". Proceedings of the National Academy of Sciences 104 14 (2007): 5872-5877. http://dx.doi.org/10.1073/pnas.0609879104.
    Open access • Published • 10.1073/pnas.0609879104
  123. Jancic, Carolina; Savina, Ariel; Wasmeier, Christina; Tolmachova, Tanya; El-Benna, Jamel; Dang, Pham My-Chan; Pascolo, Steve; et al. "Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes". Nature Cell Biology 9 4 (2007): 367-378. http://dx.doi.org/10.1038/ncb1552.
    Published • 10.1038/ncb1552
  124. "Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis". Molecular biology of the cell (2007): http://europepmc.org/articles/PMC1995718.
    10.1091/mbc.E07-03-0268
  125. Önfelt, Björn; Nedvetzki, Shlomo; Benninger, Richard K. P.; Purbhoo, Marco A.; Sowinski, Stefanie; Hume, Alistair N.; Seabra, Miguel C.; et al. "Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria". The Journal of Immunology 177 12 (2006): 8476-8483. http://dx.doi.org/10.4049/jimmunol.177.12.8476.
    Open access • Published • 10.4049/jimmunol.177.12.8476
  126. Onfelt B; Nedvetzki S; Benninger RK; Purbhoo MA; Sowinski S; Hume AN; Seabra MC; et al. "Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.". (2006): http://europepmc.org/abstract/med/17142745.
  127. Leung, Ka Fai; Baron, Rudi; Ali, Bassam R.; Magee, Anthony I.; Seabra, Miguel C.. "Rab GTPases Containing a CAAXMotif Are Processed Post-geranylgeranylation by Proteolysis and Methylation". Journal of Biological Chemistry 282 2 (2006): 1487-1497. http://dx.doi.org/10.1074/jbc.m605557200.
    Open access • Published • 10.1074/jbc.m605557200
  128. Hume, Alistair N.; Tarafder, Abul K.; Ramalho, José S.; Sviderskaya, Elena V.; Seabra, Miguel C.. "A Coiled-Coil Domain of Melanophilin Is Essential for Myosin Va Recruitment and Melanosome Transport in Melanocytes". Molecular Biology of the Cell 17 11 (2006): 4720-4735. http://dx.doi.org/10.1091/mbc.e06-05-0457.
    Open access • Published • 10.1091/mbc.e06-05-0457
  129. Wasmeier, Christina; Romao, Maryse; Plowright, Lynn; Bennett, Dorothy C.; Raposo, Grac¸a; Seabra, Miguel C.. "Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes". Journal of Cell Biology 175 2 (2006): 271-281. http://dx.doi.org/10.1083/jcb.200606050.
    Open access • Published • 10.1083/jcb.200606050
  130. Savina, Ariel; Jancic, Carolina; Hugues, Stephanie; Guermonprez, Pierre; Vargas, Pablo; Moura, Ivan Cruz; Lennon-Duménil, Ana-Maria; et al. "NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells". Cell 126 1 (2006): 205-218. http://dx.doi.org/10.1016/j.cell.2006.05.035.
    Open access • Published • 10.1016/j.cell.2006.05.035
  131. Tolmachova, T.. "Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia". Journal of Clinical Investigation 116 2 (2006): 386-394. http://dx.doi.org/10.1172/jci26617.
    Open access • Published • 10.1172/jci26617
  132. Leung, Ka Fai; Baron, Rudi; Seabra, Miguel C.. "Thematic review series: Lipid Posttranslational Modifications.Geranylgeranylation of Rab GTPases". Journal of Lipid Research 47 3 (2006): 467-475. http://dx.doi.org/10.1194/jlr.r500017-jlr200.
    Open access • 10.1194/jlr.r500017-jlr200
  133. "A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes". Molecular biology of the cell (2006): http://europepmc.org/articles/PMC1635380.
    10.1091/mbc.E06-05-0457
  134. "Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia". The Journal of clinical investigation (2006): http://europepmc.org/articles/PMC1326146.
    10.1172/JCI26617
  135. Johnson, Jennifer L.; Ellis, Beverly A.; Noack, Deborah; Seabra, Miguel C.; Catz, Sergio D.. "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase1". Biochemical Journal 391 3 (2005): 699-710. http://dx.doi.org/10.1042/bj20050380.
    Open access • Published • 10.1042/bj20050380
  136. Coxon, Fraser P.; Ebetino, Frank H.; Mules, Emilie H.; Seabra, Miguel C.; McKenna, Charles E.; Rogers, Michael J.. "Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo". Bone 37 3 (2005): 349-358. http://dx.doi.org/10.1016/j.bone.2005.04.021.
    Published • 10.1016/j.bone.2005.04.021
  137. Ali, B.R.; Seabra, M.C.. "Targeting of Rab GTPases to cellular membranes". Biochemical Society Transactions 33 4 (2005): 652-656. http://dx.doi.org/10.1042/bst0330652.
    Published • 10.1042/bst0330652
  138. Chen, Ying; Bellamy, William P.; Seabra, Miguel C.; Field, Mark C.; Ali, Bassam R.. "ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome". Human Molecular Genetics 14 17 (2005): 2559-2569. http://dx.doi.org/10.1093/hmg/ddi259.
    Published • 10.1093/hmg/ddi259
  139. Magee, Tony; Seabra, Miguel C. "Fatty acylation and prenylation of proteins: what's hot in fat". Current Opinion in Cell Biology 17 2 (2005): 190-196. http://dx.doi.org/10.1016/j.ceb.2005.02.003.
    Published • 10.1016/j.ceb.2005.02.003
  140. "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase". The Biochemical journal (2005): http://europepmc.org/articles/PMC1276972.
    10.1042/BJ20050380
  141. Ali, B. R.. "Multiple regions contribute to membrane targeting of Rab GTPases". Journal of Cell Science 117 26 (2004): 6401-6412. http://dx.doi.org/10.1242/jcs.01542.
    Open access • Published • 10.1242/jcs.01542
  142. Westbroek, Wendy; Lambert, Jo; Schepper, Sofie De; Kleta, Robert; Bossche, Karolien Van Den; Seabra, Miguel C.; Huizing, Marjan; Mommaas, Mieke; Naeyaert, Jean Marie. "Rab27b is Up-Regulated in Human Griscelli Syndrome Type II Melanocytes and Linked to the Actin Cytoskeleton via Exon F-Myosin Va Transcripts". Pigment Cell Research 17 5 (2004): 498-505. http://dx.doi.org/10.1111/j.1600-0749.2004.00173.x.
    Published • 10.1111/j.1600-0749.2004.00173.x
  143. Seabra, Miguel C; Wasmeier, Christina. "Controlling the location and activation of Rab GTPases". Current Opinion in Cell Biology 16 4 (2004): 451-457. http://dx.doi.org/10.1016/j.ceb.2004.06.014.
    Published • 10.1016/j.ceb.2004.06.014
  144. Futter, Clare E.; Ramalho, José S.; Jaissle, Gesine B.; Seeliger, Mathias W.; Seabra, Miguel C.. "The Role of Rab27a in the Regulation of Melanosome Distribution within Retinal Pigment Epithelial Cells". Molecular Biology of the Cell 15 5 (2004): 2264-2275. http://dx.doi.org/10.1091/mbc.e03-10-0772.
    Open access • Published • 10.1091/mbc.e03-10-0772
  145. Seabra, Miguel C.; Coudrier, Evelyne. "Rab GTPases and Myosin Motors in Organelle Motility". Traffic 5 6 (2004): 393-399. http://dx.doi.org/10.1111/j.1398-9219.2004.00190.x.
    Open access • Published • 10.1111/j.1398-9219.2004.00190.x
  146. Barral, Duarte C.; Seabra, Miguel C.. "The Melanosome as a Model to Study Organelle Motility in Mammals". Pigment Cell Research 17 2 (2004): 111-118. http://dx.doi.org/10.1111/j.1600-0749.2004.00138.x.
    Published • 10.1111/j.1600-0749.2004.00138.x
  147. Ramalho, J S. "Mouse genetic corneal disease resulting from transgenic insertional mutagenesis". British Journal of Ophthalmology 88 3 (2004): 428-432. http://dx.doi.org/10.1136/bjo.2003.028787.
    Open access • 10.1136/bjo.2003.028787
  148. Tolmachova, Tanya; Anders, Ross; Stinchcombe, Jane; Bossi, Giovanna; Griffiths, Gillian M.; Huxley, Clare; Seabra, Miguel C.. "A General Role for Rab27a in Secretory Cells". Molecular Biology of the Cell 15 1 (2004): 332-344. http://dx.doi.org/10.1091/mbc.e03-07-0452.
    Open access • Published • 10.1091/mbc.e03-07-0452
  149. "A general role for Rab27a in secretory cells". Molecular biology of the cell (2004): http://europepmc.org/articles/PMC307551.
    10.1091/mbc.E03-07-0452
  150. "The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells". Molecular biology of the cell (2004): http://europepmc.org/articles/PMC404021.
    10.1091/mbc.E03-10-0772
  151. Marques, MPM; Miranda, MA; Pereira, E; de Lima, MCP; da Cruz, MTG; Reis, E; Seabra, M; Teixeira, LJ. "Cytotoxic activity of metal complexes of biogenic polyamines: Polynuclear platinum(II) chelates". Journal of Medicinal Chemistry (2004): https://publons.com/publon/6017759/.
    10.1021/JM0311238
  152. Tiwari, Sanjay; Italiano, Joseph E.; Barral, Duarte C.; Mules, Emilie H.; Novak, Edward K.; Swank, Richard T.; Seabra, Miguel C.; Shivdasani, Ramesh A.. "A role for Rab27b in NF-E2-dependent pathways of platelet formation". Blood 102 12 (2003): 3970-3979. http://dx.doi.org/10.1182/blood-2003-03-0977.
    Published • 10.1182/blood-2003-03-0977
  153. MAGEE, Anthony I.; SEABRA, Miguel C.. "Are prenyl groups on proteins sticky fingers or greasy handles?". Biochemical Journal 376 1 (2003): e3-e4. http://dx.doi.org/10.1042/bj20031531.
    Open access • Published • 10.1042/bj20031531
  154. Hannah, M. J.. "Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type". Journal of Cell Science 116 19 (2003): 3939-3948. http://dx.doi.org/10.1242/jcs.00711.
    Open access • Published • 10.1242/jcs.00711
  155. Larijani, Banafshé; Hume, Alistair N.; Tarafder, Abul K.; Seabra, Miguel C.. "Multiple Factors Contribute to Inefficient Prenylation of Rab27a in Rab Prenylation Diseases". Journal of Biological Chemistry 278 47 (2003): 46798-46804. http://dx.doi.org/10.1074/jbc.m307799200.
    Open access • Published • 10.1074/jbc.m307799200
  156. Gomes, Anita Q.; Ali, Bassam R.; Ramalho, José S.; Godfrey, Richard F.; Barral, Duarte C.; Hume, Alistair N.; Seabra, Miguel C.. "Membrane Targeting of Rab GTPases Is Influenced by the Prenylation Motif". Molecular Biology of the Cell 14 5 (2003): 1882-1899. http://dx.doi.org/10.1091/mbc.e02-10-0639.
    Open access • Published • 10.1091/mbc.e02-10-0639
  157. Gomes, Anita Q.; Ali, Bassam R.; Ramalho, José S.; Godfrey, Richard F.; Barral, Duarte C.; Hume, Alistair N.; Seabra, Miguel C.. "Membrane Targeting of Rab GTPases Is Influenced by the Prenylation Motif". Molecular Biology of the Cell 14 5 (2003): 1882-1899. http://dx.doi.org/10.1091/mbc.e02-10-0639.
    Open access • Published • 10.1091/mbc.e02-10-0639
  158. Anand, Vibha; Barral, Duarte C; Zeng, Yong; Brunsmann, Frank; Maguire, Albert M; Seabra, Miguel C; Bennett, Jean. "Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus". Vision Research 43 8 (2003): 919-926. http://dx.doi.org/10.1016/s0042-6989(02)00389-9.
    Open access • 10.1016/s0042-6989(02)00389-9
  159. Pereira-Leal, José B.; Strom, Molly; Godfrey, Richard F.; Seabra, Miguel C.. "Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface". Biochemical and Biophysical Research Communications 301 1 (2003): 92-97. http://dx.doi.org/10.1016/s0006-291x(02)02963-7.
    Published • 10.1016/s0006-291x(02)02963-7
  160. "Are prenyl groups on proteins sticky fingers or greasy handles?". The Biochemical journal (2003): http://europepmc.org/articles/PMC1223795.
    10.1042/BJ20031531
  161. "Membrane targeting of Rab GTPases is influenced by the prenylation motif". Molecular biology of the cell (2003): http://europepmc.org/articles/PMC165084.
    10.1091/mbc.E02-10-0639
  162. Barral, D. C.. "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". Journal of Clinical Investigation 110 8 (2002): 1213-1213. http://dx.doi.org/10.1172/jci200215058e.
    Open access • Published • 10.1172/jci200215058e
  163. Strom, Molly; Hume, Alistair N.; Tarafder, Abul K.; Barkagianni, Eleni; Seabra, Miguel C.. "A Family of Rab27-binding Proteins". Journal of Biological Chemistry 277 28 (2002): 25423-25430. http://dx.doi.org/10.1074/jbc.m202574200.
    Open access • Published • 10.1074/jbc.m202574200
  164. Hume, Alistair N.; Collinson, Lucy M.; Hopkins, Colin R.; Strom, Molly; Barral, Duarte C.; Bossi, Giovanna; Griffiths, Gillian M.; Seabra, Miguel C.. "The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes". Traffic 3 3 (2002): 193-202. http://dx.doi.org/10.1034/j.1600-0854.2002.030305.x.
    Open access • Published • 10.1034/j.1600-0854.2002.030305.x
  165. Seabra, Miguel C; Mules, Emilie H; Hume, Alistair N. "Rab GTPases, intracellular traffic and disease". Trends in Molecular Medicine 8 1 (2002): 23-30. http://dx.doi.org/10.1016/s1471-4914(01)02227-4.
    10.1016/s1471-4914(01)02227-4
  166. Pereira-Leal JB; Gomes AQ; Seabra MC. "Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase.". (2002): http://europepmc.org/abstract/med/12094584.
  167. Ramalho, José S; Anders, Ross; Jaissle, Gesine B; Seeliger, Mathias W; Huxley, Clare; Seabra, Miguel C. "BMC Cell Biology". BMC Cell Biology 3 1 (2002): 26. http://dx.doi.org/10.1186/1471-2121-3-26.
    Open access • Published • 10.1186/1471-2121-3-26
  168. "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". The Journal of clinical investigation (2002): http://europepmc.org/articles/PMC150811.
    10.1172/JCI0215058
  169. Pereira-Leal, José B.; Seabra, Miguel C.. "Evolution of the rab family of small GTP-binding proteins". Journal of Molecular Biology 313 4 (2001): 889-901. http://dx.doi.org/10.1006/jmbi.2001.5072.
    Published • 10.1006/jmbi.2001.5072
  170. Coxon, Fraser P.; Helfrich, Miep H.; Larijani, Banafshe; Muzylak, Mariusz; Dunford, James E.; Marshall, Deborah; McKinnon, Alastair D.; et al. "Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages". Journal of Biological Chemistry 276 51 (2001): 48213-48222. http://dx.doi.org/10.1074/jbc.m106473200.
    Open access • Published • 10.1074/jbc.m106473200
  171. Marks, Michael S.; Seabra, Miguel C.. "The melanosome: membrane dynamics in black and white". Nature Reviews Molecular Cell Biology 2 10 (2001): 738-748. http://dx.doi.org/10.1038/35096009.
    10.1038/35096009
  172. Pereira-Leal, José B; Hume, Alistair N; Seabra, Miguel C. "Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease". FEBS Letters 498 2-3 (2001): 197-200. http://dx.doi.org/10.1016/s0014-5793(01)02483-8.
    10.1016/s0014-5793(01)02483-8
  173. Syed, Nasreen; Smith, Julie E; John, Sinoj K; Seabra, Miguel C; Aguirre, Gustavo D; Milam, Ann H. "Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia". Ophthalmology 108 4 (2001): 711-720. http://dx.doi.org/10.1016/s0161-6420(00)00643-6.
    Published • 10.1016/s0161-6420(00)00643-6
  174. Hume, Alistair N.; Collinson, Lucy M.; Rapak, Andrzej; Gomes, Anita Q.; Hopkins, Colin R.; Seabra, Miguel C.. "Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes". Journal of Cell Biology 152 4 (2001): 795-808. http://dx.doi.org/10.1083/jcb.152.4.795.
    Open access • Published • 10.1083/jcb.152.4.795
  175. Stinchcombe, Jane C.; Barral, Duarte C.; Mules, Emilie H.; Booth, Sarah; Hume, Alistair N.; Machesky, Laura M.; Seabra, Miguel C.; Griffiths, Gillian M.. "Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes". Journal of Cell Biology 152 4 (2001): 825-834. http://dx.doi.org/10.1083/jcb.152.4.825.
    Open access • Published • 10.1083/jcb.152.4.825
  176. Ramalho, José S; Tolmachova, Tanya; Hume, Alistair N; McGuigan, Amanda; Gregory-Evans, Cheryl Y; Huxley, Clare; Seabra, Miguel C. "BMC Genetics". BMC Genetics 2 1 (2001): 2. http://dx.doi.org/10.1186/1471-2156-2-2.
    Open access • 10.1186/1471-2156-2-2
  177. Miguel C Seabra. "Identification of a phosphonocarboxylate analogue of risedronate which inhibits geranylgeranyl transferase II and selectively prevents prenylation of Rab proteins in osteoclasts". Bone (2001): https://publons.com/publon/12022269/.
  178. "Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages". The Journal of biological chemistry (2001): http://intl.jbc.org/cgi/content/full/276/51/48213.
    10.1074/JBC.M106473200
  179. Ramalho, J.S.; Tolmachova, T.; Hume, A.N.; McGuigan, A.; Gregory-Evans, C.Y.; Huxley, C.; Seabra, M.C.. "Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.". BMC genetics [electronic resource] 2 1 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-18744416632&partnerID=MN8TOARS.
  180. Bergo, Martin O.; Leung, Gordon K.; Ambroziak, Patricia; Otto, James C.; Casey, Patrick J.; Gomes, Anita Q.; Seabra, Miguel C.; Young, Stephen G.. "Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice". Journal of Biological Chemistry 276 8 (2000): 5841-5845. http://dx.doi.org/10.1074/jbc.c000831200.
    Open access • Published • 10.1074/jbc.c000831200
  181. Pereira-Leal, José B; Seabra, Miguel C. "The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily 1 1Edited by M. Yaniv". Journal of Molecular Biology 301 4 (2000): 1077-1087. http://dx.doi.org/10.1006/jmbi.2000.4010.
    Published • 10.1006/jmbi.2000.4010
  182. Detter, J. C.; Zhang, Q.; Mules, E. H.; Novak, E. K.; Mishra, V. S.; Li, W.; McMurtrie, E. B.; et al. "Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis". Proceedings of the National Academy of Sciences 97 8 (2000): 4144-4149. http://dx.doi.org/10.1073/pnas.080517697.
    Open access • Published • 10.1073/pnas.080517697
  183. Zhang, Hong; Seabra, Miguel C; Deisenhofer, Johann. "Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution". Structure 8 3 (2000): 241-251. http://dx.doi.org/10.1016/s0969-2126(00)00102-7.
    Open access • 10.1016/s0969-2126(00)00102-7
  184. Tolmachova, Tanya; Ramalho, José S.; Anant, Janmeet S.; Schultz, Roger A.; Huxley, Clare M.; Seabra, Miguel C.. "Cloning, mapping and characterization of the human RAB27A gene". Gene 239 1 (1999): 109-116. http://dx.doi.org/10.1016/s0378-1119(99)00371-6.
    10.1016/s0378-1119(99)00371-6
  185. Desnoyers, L.; Seabra, M. C.. "Single prenyl-binding site on protein prenyl transferases". Proceedings of the National Academy of Sciences 95 21 (1998): 12266-12270. http://dx.doi.org/10.1073/pnas.95.21.12266.
    Open access • Published • 10.1073/pnas.95.21.12266
  186. MacDonald, I. "A practical diagnostic test for choroideremia". Ophthalmology 105 9 (1998): 1637-1640. http://dx.doi.org/10.1016/s0161-6420(98)99031-5.
    Published • 10.1016/s0161-6420(98)99031-5
  187. Anant, Janmeet S.; Desnoyers, Luc; Machius, Mischa; Demeler, Borries; Hansen, Jeffrey C.; Westover, Kenneth D.; Deisenhofer, Johann; Seabra, Miguel C.. "Mechanism of Rab Geranylgeranylation:  Formation of the Catalytic Ternary Complex†". Biochemistry 37 36 (1998): 12559-12568. http://dx.doi.org/10.1021/bi980881a.
    Open access • 10.1021/bi980881a
  188. Seabra, M.C.; Seabra, Miguel. "Membrane association and targeting of prenylated Ras-like GTPases". Cellular Signalling 10 3 (1998): 167-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031970317&partnerID=MN8TOARS.
    10.1016/S0898-6568(97)00120-4
  189. "Single prenyl-binding site on protein prenyl transferases". Proceedings of the National Academy of Sciences of the United States of America (1998): http://europepmc.org/articles/PMC22820.
    10.1073/PNAS.95.21.12266
  190. Bokhoven, Hans Van; Rawson, Robert B.; Merkx, Gerard F.M.; Cremers, Frans P.M.; Seabra, Miguel C.. "cDNA Cloning and Chromosomal Localization of the Genes Encoding the a- and ß-Subunits of Human Rab Geranylgeranyl Transferase: The 3' End of the a-Subunit Gene Overlaps with the Transglutaminase 1 Gene Promoter". Genomics 38 2 (1996): 133-140. http://dx.doi.org/10.1006/geno.1996.0608.
    10.1006/geno.1996.0608
  191. Rybin, Vladimir; Ullrich, Oliver; Rubino, Mariantonietta; Alexandrov, Kirill; Simon, Iris; Seabra, Miguel C.; Goody, Roger; Zerial, Marino. "GTPase activity of Rab5 acts as a timer for endocytic membrane fusion". Nature 383 6597 (1996): 266-269. http://dx.doi.org/10.1038/383266a0.
    Published • 10.1038/383266a0
  192. Desnoyers, L.; Anant, J. S.; Seabra, M. C.. "Geranylgeranylation of Rab proteins". Biochemical Society Transactions 24 3 (1996): 699-703. http://dx.doi.org/10.1042/bst0240699.
    Published • 10.1042/bst0240699
  193. Seabra, Miguel C.. "Nucleotide Dependence of Rab Geranylgeranylation". Journal of Biological Chemistry 271 24 (1996): 14398-14404. http://dx.doi.org/10.1074/jbc.271.24.14398.
    Open access • Published • 10.1074/jbc.271.24.14398
  194. Casey, Patrick J.; Seabra, Miguel C.. "Protein Prenyltransferases". Journal of Biological Chemistry 271 10 (1996): 5289-5292. http://dx.doi.org/10.1074/jbc.271.10.5289.
    Open access • Published • 10.1074/jbc.271.10.5289
  195. Wyne, Kathleen L.; Pathak, Ravindra K.; Seabra, Miguel C.; Hobbs, Helen H.. "Expression of the VLDL Receptor in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology 16 3 (1996): 407-415. http://dx.doi.org/10.1161/01.atv.16.3.407.
    Open access • 10.1161/01.atv.16.3.407
  196. Shen, Fang; Seabra, Miguel C.. "Mechanism of Digeranylgeranylation of Rab Proteins". Journal of Biological Chemistry 271 7 (1996): 3692-3698. http://dx.doi.org/10.1074/jbc.271.7.3692.
    Open access • Published • 10.1074/jbc.271.7.3692
  197. Mooser, V; Seabra, M C; Abedin, M; Landschulz, K T; Marcovina, S; Hobbs, H H. "Apolipoprotein(a) kringle 4-containing fragments in human urine. Relationship to plasma levels of lipoprotein(a).". Journal of Clinical Investigation 97 3 (1996): 858-864. http://dx.doi.org/10.1172/jci118487.
    Open access • Published • 10.1172/jci118487
  198. Seabra, Miguel C.. "New insights into the pathogenesis of choroideremia: a tale of two REPs". Ophthalmic Genetics 17 2 (1996): 43-46. http://dx.doi.org/10.3109/13816819609057869.
    Open access • 10.3109/13816819609057869
  199. Seabra, MC. "Nucleotide dependence of Rab geranylgeranylation - Rab escort protein interacts preferentially with GDP-bound Rab". Journal of Biological Chemistry (1996): https://publons.com/publon/11687801/.
    10.1074/JBC.271.24.14398
  200. Seabra, MC; Shen, F. "Mechanism of digeranylgeranylation of rab proteins - Formation of a complex between monogeranylgeranyl-rab and rab escort protein". Journal of Biological Chemistry (1996): https://publons.com/publon/11687808/.
  201. Seabra, MC; Cremers, FPM; Merkx, GFM; Rawson, RB; vanBokhoven, H. "cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter". Genomics (1996): https://publons.com/publon/11687795/.
  202. Seabra, M.C.. "New insights into the pathogenesis of choroideremia: a tale of two REPs.". Ophthalmic genetics 17 2 (1996): 43-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030158607&partnerID=MN8TOARS.
  203. Shen, F.; Seabra, M.C.. "Mechanism of digeranylgeranylation of rab proteins: Formation of a complex between Monogeranylgeranyl-Rab and Rab escort protein". Journal of Biological Chemistry 271 7 (1996): 3692-3698. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030051303&partnerID=MN8TOARS.
  204. Mooser, V.; Seabra, M.C.; Abedin, M.; Landschulz, K.T.; Marcovina, S.; Hobbs, H.H.. "Apolipoprotein(a) kringle 4-containing fragments in human urine: Relationship to plasma levels of lipoprotein(a)". Journal of Clinical Investigation 97 3 (1996): 858-864. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030027648&partnerID=MN8TOARS.
  205. Zerial, M; Goody, R; Seabra, M; Alexandrov, K; Ullrich, O; Rybin, V; Rubino, M. "GTPase activity of RAB5 as a timer for endocytic membrane fusion". Molecular Biology of the Cell (1996): https://publons.com/publon/10407425/.
  206. Seabra, M.C.. "Nucleotide dependence of rab geranylgeranylation rab escort protein interacts preferentially with GDP-bound Rab". Journal of Biological Chemistry 271 24 (1996): 14398-14404. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030010536&partnerID=MN8TOARS.
  207. Seabra, Miguel C.; Ho, Yiu K.; Anant, Janmeet S.. "Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia". Journal of Biological Chemistry 270 41 (1995): 24420-24427. http://dx.doi.org/10.1074/jbc.270.41.24420.
    Open access • Published • 10.1074/jbc.270.41.24420
  208. S A Armstrong; M S Brown; J L Goldstein; Seabra, Miguel C.. "Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins". Methods in Enzymology 257 (1995): 30-41. http://dx.doi.org/10.1074/jbc.271.24.14398.
    Published
  209. Farnsworth, C. C.; Seabra, M. C.; Ericsson, L. H.; Gelb, M. H.; Glomset, J. A.. "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.". Proceedings of the National Academy of Sciences 91 25 (1994): 11963-11967. http://dx.doi.org/10.1073/pnas.91.25.11963.
    Open access • Published • 10.1073/pnas.91.25.11963
  210. Alexandrov, K.; Horiuchi, H.; Steele-Mortimer, O.; Seabra, M.C.; Zerial, M.. "Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.". The EMBO Journal 13 22 (1994): 5262-5273. http://dx.doi.org/10.1002/j.1460-2075.1994.tb06860.x.
    Open access • 10.1002/j.1460-2075.1994.tb06860.x
  211. Smeland, T. E.; Seabra, M. C.; Goldstein, J. L.; Brown, M. S.. "Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.". Proceedings of the National Academy of Sciences 91 22 (1994): 10712-10716. http://dx.doi.org/10.1073/pnas.91.22.10712.
    Published • 10.1073/pnas.91.22.10712
  212. Seabra, Miguel. "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of biological chemistry (1994): http://europepmc.org/abstract/MED/8294464.
    Open access
  213. Seabra, M.; Brown, M.; Goldstein, J.. "Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase". Science 259 5093 (1993): 377-381. http://dx.doi.org/10.1126/science.8380507.
    10.1126/science.8380507
  214. Seabra, Miguel. "cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein". Cell (1993): https://doi.org/10.1016/0092-8674(93)90639-8.
    10.1016/0092-8674(93)90639-8
  215. Armstrong, S.A.; Seabra, M.C.; Südhof, T.C.; Goldstein, J.L.; Brown, M.S.. "cDNA cloning and expression of the a and ß subunits of rat rab geranylgeranyl transferase". Journal of Biological Chemistry 268 16 (1993): 12221-12229. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027298707&partnerID=MN8TOARS.
    Open access
  216. BROWN, MS; GOLDSTEIN, JL; SUDHOF, TC; SEABRA, MC; ARMSTRONG, SA. "CDNA CLONING AND EXPRESSION OF THE ALPHA-SUBUNIT AND BETA-SUBUNIT OF RAT RAB GERANYLGERANYL TRANSFERASE". FASEB Journal (1993): https://publons.com/publon/11687821/.
  217. Seabra, Miguel C.; Brown, Michael S.; Slaughter, Clive A.; Südhof, Thomas C.; Goldstein, Joseph L.. "Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product". Cell 70 6 (1992): 1049-1057. http://dx.doi.org/10.1016/0092-8674(92)90253-9.
    Published • 10.1016/0092-8674(92)90253-9
  218. Miguel C. Seabra; J L Goldstein; T C Südhof; M S Brown. "Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys". Journal of Biological Chemistry 267 20 (1992): 14497-14503. https://www.jbc.org/content/267/20/14497.long.
    Open access • Published
  219. Reiss, Y.; Seabra, M. C.; Brown, M. S.; Goldstein, J. L.. "p21ras Farnesyltransferase: purification and properties of the enzyme". Biochemical Society Transactions 20 2 (1992): 487-488. http://dx.doi.org/10.1042/bst0200487.
    Published • 10.1042/bst0200487
  220. Seabra, M.C.; Goldstein, J.L.; Südhof, T.C.; Brown, M.S.. "Rab geranylgeranyl transferase: A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys". Journal of Biological Chemistry 267 20 (1992): 14497-14503. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026629308&partnerID=MN8TOARS.
    Open access
  221. GOLDSTEIN, JL; BROWN, MS; SEABRA, MC; REISS, Y. "P21RAS FARNESYLTRANSFERASE - PURIFICATION AND PROPERTIES OF THE ENZYME". Biochemical Society Transactions (1992): https://publons.com/publon/11687817/.
    10.1042/BST0200487
  222. BROWN, MS; SUDHOF, TC; GOLDSTEIN, JL; SEABRA, MC. "RAB GERANYLGERANYL TRANSFERASE - A MULTISUBUNIT ENZYME THAT PRENYLATES GTP-BINDING PROTEINS TERMINATING IN CYS-X-CYS OR CYS-CYS". Journal of Biological Chemistry (1992): https://publons.com/publon/11687818/.
  223. Seabra, Miguel C.; Reiss, Yuval; Casey, Patrick J.; Brown, Michael S.; Goldstein, Joseph L.. "Protein farnesyltransferase and geranylgeranyltransferase share a common a subunit". Cell 65 3 (1991): 429-434. http://dx.doi.org/10.1016/0092-8674(91)90460-g.
    Published • 10.1016/0092-8674(91)90460-g
  224. Reiss, Y.; Seabra, M.C.; Armstrong, S.A.; Slaughter, C.A.; Goldstein, J.L.; Brown, M.S.. "Nonidentical subunits of p21H-ras farnesyltransferase: Peptide binding and farnesyl pyrophosphate carrier functions". Journal of Biological Chemistry 266 16 (1991): 10672-10677. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025923649&partnerID=MN8TOARS.
    Open access
  225. Seabra, M.C.; Reiss, Y.; Casey, P.J.; Brown, M.S.; Goldstein, J.L.. "Protein farnesyltransferase and geranylgeranyltransferase share a common a subunit". Cell 65 3 (1991): 429-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025819073&partnerID=MN8TOARS.
    10.1016/0092-8674(91)90460-G
  226. BROWN, MS; GOLDSTEIN, JL; SLAUGHTER, CA; ARMSTRONG, SA; SEABRA, MC; REISS, Y. "NONIDENTICAL SUBUNITS OF P21H-RAS FARNESYLTRANSFERASE - PEPTIDE BINDING AND FARNESYL PYROPHOSPHATE CARRIER FUNCTIONS". Journal of Biological Chemistry (1991): https://publons.com/publon/11687816/.
  227. REISS, Y; SEABRA, M; GOLDSTEIN, J; BROWN, M. "Purification of ras farnesyl:Protein transferase". Methods 1 3 (1990): 241-245. http://dx.doi.org/10.1016/s1046-2023(05)80323-8.
    10.1016/s1046-2023(05)80323-8
  228. Reiss, Yuval; Goldstein, Joseph L.; Seabra, Miguel C.; Casey, Patrick J.; Brown, Michael S.. "Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides". Cell 62 1 (1990): 81-88. http://dx.doi.org/10.1016/0092-8674(90)90242-7.
    Published • 10.1016/0092-8674(90)90242-7
  229. Reiss, Y.; Seabra, M.C.; Goldstein, J.L.; Brown, M.S.. "Purification of ras farnesyl:Protein transferase". Methods 1 3 (1990): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000504764&partnerID=MN8TOARS.
  230. Mesquita, M F; Seabra, M P; Halpern, M J. "Simple carbohydrates in the diet". The American Journal of Clinical Nutrition 45 5 (1987): 1197-1201. http://dx.doi.org/10.1093/ajcn/45.5.1197.
    Published • 10.1093/ajcn/45.5.1197
Preprint
  1. Luisa de Lemos; Pedro Antas; Inês S. Ferreira; Inês Paz Santos; Catarina M. Gomes; Catarina Brito; Miguel C. Seabra; Sandra Tenreiro. "3D human retinal organoid model for the study of early diabetic retinopathy". 2023. https://doi.org/10.1101/2023.09.04.556258.
    10.1101/2023.09.04.556258
  2. Michael J. Hall; Sara Lopes-Ventura; Matilde V. Neto; João Charneca; Patricia Zoio; Miguel C. Seabra; Abel Oliva; Duarte C. Barral. "Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer". 2022. https://doi.org/10.1101/2022.03.03.482849.
    10.1101/2022.03.03.482849

Intellectual property

Patent
  1. Miguel C. Seabra. 2011. "AAV-vectors for use in gene therapy of choroideremia". United Kingdom.
    Granted/Issued

Other

Other output
  1. Rab3a regulates melanin exocytosis induced by keratinocyte-conditioned medium. 2021. Luís C. Cabaço; Liliana Bento-Lopes; Matilde V. Neto; José S. Ramalho; Miguel C. Seabra; Duarte C. Barral. https://doi.org/10.1101/2021.05.24.445450.
    10.1101/2021.05.24.445450
  2. Melanocore uptake by keratinocytes occurs through phagocytosis and involves Protease-activated receptor-2 activation. 2021. Hugo Moreiras; Matilde V. Neto; Liliana Bento-Lopes; Cristina Escrevente; José S. Ramalho; Miguel C. Seabra; Duarte C. Barral. https://doi.org/10.1101/2021.04.13.439501.
    10.1101/2021.04.13.439501
Spin-off company
  1. 2014. Nighstar Therapeutics. https://craft.co/nightstarx-130.
  2. 2008. Sicgen Ltd. www.sicgen.pt.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/07/13 Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction ARVO Annual Meeting
2019 Lysosomal dysfunction in the Retinal pigmented Epithelium EMBO workshop Proteostasis: From organelles to organisms
(Ericeira, Portugal)
2019 Dysfunctional lysosomes in the retinal pigment epithelium LYSOCIL workshop
(Lisbon, Portugal)
2017 Molecular basis of skin pigmentation
University of Pennsylvania, Philadelphia, USA (United States)
2017 From gene discovery to gene therapy for an inherited retinopathy 1o Congresso das Escolas Médicas, Coimbra, Portugal
2017 "Molecular basis of skin pigmentation"
St Georges University of London, UK (United Kingdom)
2016 Gene therapy in the treatment of retinal dystrophies" 9th Congress of the Portuguese Society for Ophthalmology
2016 "From gene discovery to gene therapy for an inherited retinopathy in twenty years " 1st CEDOC symposium on chronic diseases, Lisbon, Portugal
(Portugal)
2016 "Melanin processing by keratinocytes after transfer" -20th European Society for Pigment Cell Research meeting, Milano, Italy
(Italy)
2016 "From gene discovery to gene therapy for an inherited retinopathy in twenty years "
CNC-IBILI, Coimbra, Portugal (Portugal)
2014 "Gene therapy in the treatment of retinal dystrophies" 57th Congress of the Portuguese Society for Ophthalmology
(Portugal)
2011 "New molecular therapies in the treatment of retinal diseases" - 54th Congress of the Portuguese Society for Ophthalmology
2011 "Preclinical trial in the mouse model for choroideremia" 1st International Choroideremia Research Symposium, Sommières, France
(France)
2011 "Melanocyte-keratinocyte interactions and the mystery of pigment transfer" 20th Congress of the European Academy of Dermatology and Venereology
(Lisbon, Portugal)
2011 "Pathogenesis of diseases involving defects in Rab GTPase function and membrane traffic" - 36th FEBS Congress
(torino, Italy)
2011 "Membrane traffic and disease" SINAL 2011
(Coimbra, Portugal)
2011 "Molecular mechanisms and new treatments for retinal degenerations" Ophthalmic Research Breakfast Meeting
Imperial College London, UK (United Kingdom)
2011 “Rab GTPases, membrane traffic and retinal degeneration” 7th PRO RETINA Research-Colloquim Potsdam
(Germany)
2010 “Intracellular membrane traffic and retinal degeneration: from bench to bedside” The Doctor Jessie Mole Lecture
University of Oxford, Reino Unido
2010 “CEDOC: o novo centro de investigação da Faculdade de Ciências Médicas”
Hospital da Luz, Lisboa, Portugal
2010 “Molecular mechanisms of regulated exocytosis” Tear Film and Ocular Surface Meeting
(Florença, Italy)
2010 “Mechanisms of melanosome transfer in human skin” 16th Meeting of the European Society for Pigment Cell Research, Hinxton
(United Kingdom)
2010 “Mechanisms of Rab GTPase-dependent disease” Gordon Research Conferences: Lysosomes & Endocytosis, Andover
(United States)
2010 “Terapia Génica: substituir genes que não funcionam” – Tedx Lisboa
2010 “Rab GTPases in membrane traffic and disease” 3rd Annual Meeting of the German Society for Cell Biology, Regensburg
(Germany)
2010 “Rab GTPases, membrane traffic and disease” Intracellular Trafficking Processes
Weizmann Institute of Science, Tel-Aviv
2010 “Medicina Molecular: mecanismos de doença e novas terapias”
, Instituto de Higiene e Medicina Tropical (Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2022/09/01 - Current Mechanisms of Cell Death in Choroideremia
Co-supervisor of Ana Fragoso Fonseca
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/07 - Current Bioengineered in vitro model of retinal pigmented epithelium of human eye
Supervisor
PhD in Biomedicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - Current Stem cell-derived Retinal Pigment Epithelium Models of Lysosomal Dysfunction in Disease
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019 Melanocyte-keratinocyte signalling in melanin secretion
Supervisor of MATILDE ROQUETE VIANA NETO
Envelhecimento e Doenças Crónicas (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2018 Molecular basis of the cross-talk between skin melanocytes and keratinocytes
Supervisor of JOÃO MIGUEL CONDEÇA CHARNECA
Mecanismos de Doença e Medicina Regenerativa (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2018 Avaliação da Permeabilidade da Barreira Hematoencefálica num modelo animal da doença de Alzheimer – Estudos de perfusão em Ressonância Magnética
Co-supervisor
Radiações Aplicadas às Tecnologias da Saúde (Master)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2018 - 2018 Molecular mechanisms of melanin secretion by melanocytes and processing within keratinocytes
Supervisor
Biomedicina (associação) (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2010 - 2010 Cellular reprogramming strategies for degenarative disorders involving the retinal pigment epithelium
Supervisor
Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2008 - 2008 New roles of RabGTPases on eye diseases: targeting VEGF secretion
Supervisor
Ciências da Vida (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006 - 2006 Dissecting the molecular interaction between hepatocytes and Plasmodium liver parasites
Supervisor
Biologia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2002 - 2002 Analysis of Mammalian Rab27a and Rab27b Genes and Implications for Disease
Supervisor
Universidade de Coimbra, Portugal
2001 - 2001 The Rab Family os Small Gtpases: Structural Determinants of Lipid Modification and Function
Supervisor
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2013 - 2013 Organization of European Society for Pigment Cell Research, Portugal (2013 - 2013)
Congress (Co-organisor)
2009 - 2009 FASEB Summer Research Conference, Vermont, USA (2009 - 2009)
Conference (Co-organisor)
2009 - 2009 ARVO/ISOCB Meeting, Portugal (2009 - 2009)
Meeting
2005 - 2005 Biochemical Society Focused Meeting, Membrane Traffic, UK (2005 - 2005)
Meeting (Co-organisor)
2004 - 2004 2nd International Workshop on Lysosome-related Organelles, Portugal (2004 - 2004)
Workshop (Co-organisor)
2002 - 2002 1st International Workshop on Lysosome-related Organelles, Portugal (2002 - 2002)
Workshop

Association member

Society Organization name Role
2008 - 2013 Member of Council, European Society for Pigment Cell Research

Committee member

Activity description
Role
Institution / Organization
2021 - Current Head of Global Eye Initiative at Fundação Champalimaud
Director
Fundação Champalimaud, Portugal
2021 - 2023 Director of the Doctoral Programmes at Fundação Champalimaud
Director
Fundação Champalimaud, Portugal
2017 - 2017 Member of Search Committee for Director of Gulbenkian Institute, Fundação Calouste Gulbenkian
Member
2015 - 2017 Member of the Scientific Council (FCM-UNL)
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2009 - 2011 Member of Fundação para a Ciência e Tecnologia (FCT) Scientific Council for Life & Health Sciences
Member
Fundação para a Ciência e a Tecnologia, Portugal
2007 - 2009 Vice–President of the Scientific Council (FCM-UNL)
President / Vice-president
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1998 - 2009 External Scientific Board Member, Vision Research Institute (IBILI)
Member
CNC.IBILI, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Coordinator of the PhD program in Health Sciences (FCM/UNL) Ciências da Saúde (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - Current Molecular mechanisms of disease, 5th year med course Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007 - 2015 Tissues, cells and molecules; 1st year med course Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2007 - 2015 Nutrition and metabolism, 1st year med course Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1997 - 2007 Cell and molecular biology, 1st year med course Medicine Imperial College London, United Kingdom
2000 - 2006 Director, Gulbenkian PhD Programme in Biomedicine, Lisbon, Portugal Biomedicina (Doutoramento) Instituto Gulbenkian de Ciência, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2007 - 2010 Member of Molecules, Genes and Cells Panel
Evaluator
Wellcome Trust, United Kingdom
2000 - 2010 Member of Medical Research Council College of Experts
Specialist
2007 - 2008 Head of Evaluation Panel, Biological Sciences
Evaluator
Fundação para a Ciência e a Tecnologia, Portugal

Interview (tv / radio show)

Program Topic
2010 - 2010 TEDxLisboa Terapia génica: substituir genes que não funcionam

Journal scientific committee

Journal title (ISSN) Publisher
2005 - 2010 Biochemical Journal (1470-8728) Portland Press
2004 - 2010 Pigment Cell & Melanoma Research (1755-148X) Wiley (Blackwell Publishing)
2004 - 2009 Journal of Biological Chemistry (1083-351X) American Society for Biochemistry and Molecular Biology
Distinctions

Award

2024 ESPCR Prize
2015 Grande Prémio BIAL de Medicina
Fundação Bial, Portugal
2006 Entrepreneurship Prize, Neotec
Agência Nacional de Inovação SA, Portugal
1997 Matilda Ziegler Research Award
E Matilda Ziegler Foundation for the Blind Inc, United States

Other distinction

2014 Medal of Distinguished Services , degree Gold
Ministério da Saúde, Portugal
2010 Dr Jessie Mole Lectureship
University of Oxford University College Oxford, United Kingdom
2010 Bolsa Terry Fox
Liga Portuguesa Contra o Cancro, Portugal
1995 Pew Scholar in the Biomedical Sciences
PEW Charitable Trusts, United States
1988 Fulbright Program Scholar
United States Bureau of Educational and Cultural Affairs Fulbright Program, United States
1988 Postgraduate Fellowship
Fundação Calouste Gulbenkian, Portugal
1986 Young Investigator Fellowship
Instituto Nacional de Investigação, Portugal