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Identification

Personal identification

Full name
Carlos Jorge Azevedo Costa Ribeiro

Citation names

  • Ribeiro, Carlos J A

Author identifiers

Ciência ID
241A-31B3-A5D2
ORCID iD
0000-0001-8002-910X
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=v0pAnYEAAAAJ
Researcher Id
ABC-9701-2021
Scopus Author Id
37034824600

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2011/01 - 2015/10
Concluded
Farmácia (Doutoramento)
Major in Especialidade: Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Design and synthesis of small molecule modulators of p53" (THESIS/DISSERTATION)
2007/09 - 2010/12
Concluded
Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
"Synthesis of spirooxindoles derivatives by 1,3-dipolar cycloaddition" (THESIS/DISSERTATION)
18/20
2004/11 - 2005/05
Concluded
Saúde comunitária (Pós-Graduação)
Universidade do Porto, Portugal

Cofanor, Portugal
1997/09 - 2003/07
Concluded
Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
16/20
Affiliation

Science

Category
Host institution
Employer
2019/07 - 2019/12 Postdoc (Research) University of Leeds Faculty of Engineering and Physical Sciences, United Kingdom
University of Leeds Faculty of Engineering and Physical Sciences, United Kingdom
2016/08 - 2019/06 Postdoc (Research) University of Minnesota Center for Drug Design, United States
University of Minnesota Center for Drug Design, United States
2013/05 - 2013/07 Visiting Researcher (Research) University of California Davis, United States
University of California Davis, United States
2003/02 - 2003/06 Visiting Researcher (Research) University of Strathclyde, United Kingdom
University of Strathclyde, United Kingdom

Positions / Appointments

Category
Host institution
Employer
2021/06/01 - Current Product developer Avextra Portugal, SA, Portugal
2021/06/01 - Current Product developer Psilo Pharma Inc, Canada
2008/06 - 2008/12 Diretor Técnico Pharmion - Sucursal Em Portugal, Portugal
2007/03 - 2007/09 Farmacêutico Adjunto Farmácia Sanil, Portugal
2003/09 - 2006/12 Farmacêutico Adjunto Farmácia Arnoso, Portugal
Projects

Contract

Designation Funders
2016/04/01 - 2019/04/01 Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Post-doc Fellow
Universidade do Minho, Portugal

Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. "10.7. Synthesis of a Spiroisoxazoline Oxindole by 1,3-Dipolar Cycloaddition". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. United Kingdom: Royal Society of Chemistry, 2017.
    Published
Conference poster
  1. Coelho, Diogo; Cruz, Tânia; Ribeiro, Carlos J A; Silva, Eduarda M. P.; Maria José Oliveira; Sarmento, Bruno. "A lipophilic 5-Fluorouracil prodrug to effectively encapsulate 5-FU and treat rectal cancer". Paper presented in PhD day, 5th Edition, Gandra, 2023.
  2. Borges, M. Margarida P; Gonçalves, Virgínia M. F.; Ribeiro, Carlos J A; Segundo, Marcela; Tiritan, Maria Elizabeth; Silva, Eduarda M. P.. "Development of a xanthone-BINOL conjugate as a chemosensor for the detection of chiral amino acids". Paper presented in XXVIII Encontro Nacional da SPQ, Aveiro, 2023.
Journal article
  1. Ribeiro, Carlos J A. "Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide". Journal of Medicinal Chemistry 62 9 (2019): 4669-4682. http://dx.doi.org/10.1021/acs.jmedchem.9b00274.
    10.1021/acs.jmedchem.9b00274
  2. Ribeiro, Carlos J A. "Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors". Bioorganic & Medicinal Chemistry Letters 29 2 (2019): 257-261. http://dx.doi.org/10.1016/j.bmcl.2018.11.044.
    10.1016/j.bmcl.2018.11.044
  3. Ribeiro, Carlos J A. "New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)". European Journal of Pharmaceutical Sciences 118 (2018): 67-79. http://dx.doi.org/10.1016/j.ejps.2018.03.021.
    10.1016/j.ejps.2018.03.021
  4. Ribeiro, Carlos J A. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://dx.doi.org/10.1016/j.ejmech.2017.09.037.
    10.1016/j.ejmech.2017.09.037
  5. Ribeiro, Carlos J A. "In vitro targeting of colon cancer cells using spiropyrazoline oxindoles". European Journal of Medicinal Chemistry 139 (2017): 168-179. http://dx.doi.org/10.1016/j.ejmech.2017.07.057.
    10.1016/j.ejmech.2017.07.057
  6. Ribeiro, Carlos J A. "Chemical Variations on the p53 Reactivation Theme". Pharmaceuticals 9 2 (2016): 25-25. http://dx.doi.org/10.3390/ph9020025.
    10.3390/ph9020025
  7. Ribeiro, Carlos J A. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic & Medicinal Chemistry 24 8 (2016): 1786-1792. http://dx.doi.org/10.1016/j.bmc.2016.03.005.
    10.1016/j.bmc.2016.03.005
  8. Ribeiro, Carlos J A. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://dx.doi.org/10.1039/c5md00450k.
    10.1039/c5md00450k
  9. Ribeiro, Carlos J A. "Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines". Organic Letters 16 24 (2014): 6270-6273. http://dx.doi.org/10.1021/ol5028128.
    10.1021/ol5028128
  10. Ribeiro, Carlos J A. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic & Medicinal Chemistry 22 1 (2014): 577-584. http://dx.doi.org/10.1016/j.bmc.2013.10.048.
    10.1016/j.bmc.2013.10.048
  11. Ribeiro, Carlos J A. "Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents". European Journal of Medicinal Chemistry 69 (2013): 365-372. http://dx.doi.org/10.1016/j.ejmech.2013.08.037.
    10.1016/j.ejmech.2013.08.037
  12. Ribeiro, Carlos J A. "Efficient synthesis of spiroisoxazoline oxindoles". Tetrahedron Letters 53 3 (2012): 281-284. http://dx.doi.org/10.1016/j.tetlet.2011.10.139.
    10.1016/j.tetlet.2011.10.139
  13. Ribeiro, Carlos J A. "Cell Death Targets and Potential Modulators in Alzheimers Disease". Current Pharmaceutical Design 16 25 (2010): 2851-2864. http://dx.doi.org/10.2174/138161210793176563.
    10.2174/138161210793176563
Thesis / Dissertation
  1. "Design and synthesis of small molecule modulators of p53". PhD, Universidade de Lisboa Faculdade de Farmácia, 2015. http://hdl.handle.net/10451/20616.
  2. Ribeiro, Carlos Jorge Azevedo Costa. "Síntese de Derivados Spiro-oxindoles via Cicloadição 1,3-Dipolar". Master, 2010. http://hdl.handle.net/10451/2613.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/10 A Novel Chemotype as Hepatitis B Virus Capsid Assembly Effectors 6th annual 'Wisc-e-sota' symposium
University of Minnesota and University of Wisconsin (La Crosse, United States)
2015/12 Spirooxadiazoline Oxindoles with Promising in Vitro Antitumor Activities 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry
Sociedade Portuguesa de Química (Porto, Portugal)
2014/12/09 Synthesis and Biological Evaluation of Spiroisoxazoline and Spirooxadiazoline Oxindoles as Anticancer Agents EFMC-YMCS 2014. 1st EFMC Young Medicinal Chemist Symposium
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2014/05 Synthesis and Biological Evaluation of Spiroisoxazoline Oxindoles as Anticancer Agents 4rd Portuguese Young Chemists Meeting
Portuguese Chemical Society (SPQ) and Universidade de Coimbra, Faculdade de Ciências e Tecnologia (Coimbra, Portugal)
2013/12/20 Spiroisoxazoline Oxindoles: a New Class of p53-MDM2 Interaction Inhibitors 4th iMed.UL Post-Graduate Students Meeting
Universidade de Lisboa, Faculdade de Farmácia (Lisboa, Portugal)
2013/09 Presentation of Literature Published in the Field of Cancer Stem cells - Chemical Point of View. COST Action CM1106: Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells. 2nd Working Group Meeting.
(Varsóvia, Poland)
2012/07 Synthesis and Biological Evaluation of New Spiroisoxazoline Oxindoles as Potential Anticancer Agents 32nd Edition of the European School of Medicinal Chemistry (ESMEC)
European School of Medicinal Chemistry (Urbino, Italy)
2012/05 Efficient Synthesis of New Spiroisoxazoline Oxindoles 3rd Portuguese Young Chemists Meeting
Portuguese Chemical Society (SPQ) and Universidade do Porto, faculdade de Ciências (Porto)
2011/11 Structural Characterization of a Novel Spiroisoxazoline Oxindole Modern Methods of Structure Elucidation (MMSE)
Universidade de Lisboa, Instituto Superior Técnico (Lisboa, Portugal)
Distinctions

Other distinction

2003 Eng. António de Almeida award for finishing the degree with final grade of 16/20, the highest, in the year 2002/2003, in Pharmaceutical Sciences, Faculty of Pharmacy - University of Porto
Fundação Engenheiro António de Almeida, Portugal