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Vanessa Alexandra Gonçalves de Oliveira. Concluiu o(a) Licenciatura em Bioquímica em 1999/10 pelo(a) Universidade de Lisboa Faculdade de Ciências e Doctor of Philosophy em Doutoramento em 2006 pelo(a) University of Oxford Radcliffe Department of Medicine. Publicou 15 artigos em revistas especializadas. Recebeu 8 prémio(s) e/ou homenagens. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Aluminum Hydroxide; Animals; Antibodies; Antigen Presentation; CD4 Antigens; Cell Differentiation; Cells, Cultured; Clonal Selection, Antigen-Mediated; Forkhead Transcription Factors; Interleukin-10; Interleukin-2; Lymphocyte Activation; Mice; Mice, Knockout; Mice, Transgenic; Ovalbumin; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Immune Tolerance; Skin Transplantation; .
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Identification

Personal identification

Full name
Vanessa Alexandra Gonçalves de Oliveira

Citation names

  • Oliveira, Vanessa

Author identifiers

Ciência ID
2219-6C04-8A3E
ORCID iD
0000-0001-6884-2675

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Other Medical Sciences - Other Medical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2008/09/15 - 2014/07/31
Concluded
 Medicina (Mestrado integrado)
Major in Imuno-hemoterapia
Universidade de Lisboa Faculdade de Medicina, Portugal
 15
2007/09/15 - 2008/07/31
Attended
 Medicina Dentária (Mestrado integrado)
Universidade de Lisboa Faculdade de Medicina Dentária, Portugal
 NA
2001/10/01 - 2006/01/31
Concluded
 Tese de Doutoramento (PhD) (Doctor of Philosophy)
Major in Immunology
University of Oxford Radcliffe Department of Medicine, United Kingdom
"In vitro generation of CD4+ regulatory T cells" (THESIS/DISSERTATION)
 Approved
1995/09/21 - 1999/10
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
""n/a"" (THESIS/DISSERTATION)
 15
1992 - 1995
Attended
 Engenharia Química (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Licenciatura em Engenharia Química" (THESIS/DISSERTATION)
Affiliation

Other Careers

Category
Host institution 		Employer
2016/01/01 - Current Interno (Médica) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2015/01/01 - 2015/12/31 Interno (Médica) Centro Hospitalar Barreiro Montijo EPE, Portugal

Others

Category
Host institution 		Employer
2012/08/01 - 2015/01/01 Bolsa Pós-Doutoramento Instituto de Medicina Molecular João Lobo Antunes, Portugal
2006/04/01 - 2012/04/01 Bolsa Pós-Doutoramento Instituto de Medicina Molecular João Lobo Antunes, Portugal
2001/10/01 - 2006/01/31 Doutoramento University of Oxford Radcliffe Department of Medicine, United Kingdom
1999/07/01 - 2001/09/30 BIC (Bolsa de Iniciação à Investigação Científica) student Instituto Gulbenkian de Ciência, Portugal
1998/01/02 - 2000/04/02 Tutorial lessons of Chemistry and Biology Odiestudos, Portugal
1998/09/15 - 1999/07/01 Master Thesis on Chronic Myeloid Leukemia Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Grant

Designation Funders
2016/01 - 2018/12 Immunomodulatory effect of CD6-targeting in neuroinflammation
grant.Provided by PTCRIS: 141707
 Fundação para a Ciência e a Tecnologia
2012/01 - 2014/12 Regulation of germinal centre reaction by Foxp3+ follicular T cells
grant.Provided by PTCRIS: 120225
 Fundação para a Ciência e a Tecnologia
2011/01 - 2013/12 Cellular therapy for liver-specific immune suppression
grant.Provided by PTCRIS: 114424
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/06 Tolerance induction to recombinant clotting factors in a murine model of hemophilia
grant.Provided by PTCRIS: 108267
 Fundação para a Ciência e a Tecnologia
2007/07 - 2009/12 Co-receptor and co-stimulation blockade for the induction of regulatory T cells in allergic airways disease.
grant.Provided by PTCRIS: 64279
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2016/04/01 - 2019/09/30 Efeito imunomodulador do bloqueio de CD6 na neuroinflamação
PTDC/DTP-FTO/3080/2014
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2014/12/31 Regulação da reacção do centro germinal por células T foliculares Foxp3+
PTDC/SAU-IMU/120225/2010
Post-doc Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Terapia celular para imunossupressão específica do fígado
PTDC/SAU-TOX/114424/2009
Post-doc Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/08/01 - 2013/08/01 Boosting Dendritic Cell Function to Facilitate Tolerance Induction to Recombinant Clotting Factors
Early Career Investigator Award
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto Gulbenkian de Ciência, Portugal
Concluded
2010/01/01 - 2013/06/30 Indução de tolerância a factores de coagulação recombinantes num modelo animal de hemofilia
PTDC/SAU-OSM/108267/2008
Principal investigator
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/09 - 2009/12/31 Bloqueio de co-receptores e co-estimulação para indução de células T reguladoras em alergia respiratória.
PTDC/SAU-MII/64279/2006
Post-doc Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Freitas, Raquel Filipa; Basto, Afonso; Almeida, Silvia C.P.; Santos, Rita F.; Gonçalves, Carine M.; Corria-Osorio, Jesus; Carvalho, Tânia; et al. "Modulation of CD4 T cell function via CD6-targeting". EBioMedicine 47 (2019): 427-435. http://dx.doi.org/10.1016/j.ebiom.2019.08.008.
    10.1016/j.ebiom.2019.08.008
  2. Oliveira, Vanessa G.; Saraiva, Filipa; Costa, Fátima; de Sousa, Aida Botelho. "Present and Future Strategies with Curative Intent for Hereditary Hemoglobinopathies". OBM Transplantation 3 3 (2019): 1-1. http://dx.doi.org/10.21926/obm.transplant.1903086.
    10.21926/obm.transplant.1903086
  3. Oliveira, Vanessa. "Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.". Journal of immunology (Baltimore, Md. : 1950) (2018): http://europepmc.org/abstract/med/29167234.
    10.4049/jimmunol.1601886
  4. Oliveira, Vanessa. "In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model.". Journal of controlled release : official journal of the Controlled Release Society (2015): http://europepmc.org/abstract/med/25483429.
    10.1016/j.jconrel.2014.11.033
  5. Silva, Joana M; Vandermeulen, Gaëlle; Oliveira, Vanessa G; Pinto, Sandra N; Rodrigues, Catarina; Salgado, Ana; Afonso, Carlos A; et al. "Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach". Nanomedicine 9 17 (2014): 2639-2656. http://dx.doi.org/10.2217/nnm.14.135.
    10.2217/nnm.14.135
  6. Oliveira, Vanessa G.; Agua-Doce, Ana; Curotto de Lafaille, Maria A.; Lafaille, Juan J.; Graca, Luis. "Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10". Blood 121 19 (2013): 3936-3945. http://dx.doi.org/10.1182/blood-2012-09-457135.
    10.1182/blood-2012-09-457135
  7. Caridade, M.; Oliveira, V.G.; Agua-Doce, A.; Graca, L.; Ribeiro, R.M.. "The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective". Immunology and Cell Biology (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885825144&partnerID=MN8TOARS.
    10.1038/icb.2013.63
  8. Duarte, J.; Carrié, N.; Oliveira, V.G.; Almeida, C.; Agua-Doce, A.; Rodrigues, L.; Simas, J.P.; Mars, L.T.; Graca, L.. "T cell apoptosis and induction of foxp3 + regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis". Journal of Immunology 189 4 (2012): 1680-1688. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864827341&partnerID=MN8TOARS.
    10.4049/jimmunol.1201269
  9. Oliveira, V.G.; Caridade, M.; Paiva, R.S.; Demengeot, J.; Graca, L.. "Sub-optimal CD4 + T-cell activation triggers autonomous TGF-ß-dependent conversion to Foxp3 + regulatory T cells". European Journal of Immunology 41 5 (2011): 1249-1255. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952915024&partnerID=MN8TOARS.
    10.1002/eji.201040896
  10. Wollenberg, I.; Agua-Doce, A.; Hernández, A.; Almeida, C.; Oliveira, V.G.; Faro, J.; Graca, L.. "Regulation of the germinal center reaction by Foxp3 + follicular regulatory T cells". Journal of Immunology 187 9 (2011): 4553-4560. http://www.scopus.com/inward/record.url?eid=2-s2.0-80555133319&partnerID=MN8TOARS.
    10.4049/jimmunol.1101328
  11. Long, E.T.; Baker, S.; Oliveira, V.; Sawitzkib, B.; Wood, K.J.. "Alpha-1,2-mannosidase and hence N-glycosylation are required for regulatory t cell migration and allograft tolerance in mice". PLoS ONE 5 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77749239736&partnerID=MN8TOARS.
    10.1371/journal.pone.0008894
  12. Duarte, J.; Agua-Doce, A.; Oliveira, V.G.; Fonseca, J.E.; Grac, L.. "Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice". PLoS ONE 5 5 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956413981&partnerID=MN8TOARS.
    10.1371/journal.pone.0010558
  13. Oliveira, V.; Sawitzki, B.; Chapman, S.; Appelt, C.; Gebuhr, I.; Wieckiewicz, J.; Long, E.; Wood, K.J.. "Anti-CD4-mediated selection of Treg in vitro - In vitro suppression does not predict in vivo capacity to prevent graft rejection". European Journal of Immunology 38 6 (2008): 1677-1688. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649108520&partnerID=MN8TOARS.
    10.1002/eji.200737562
  14. Carneiro, J.; Leon, K.; Caramalho, Í.; Van Den Dool, C.; Gardner, R.; Oliveira, V.; Bergman, M.-L.; et al. "When three is not a crowd: A Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells". Immunological Reviews 216 1 (2007): 48-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947192440&partnerID=MN8TOARS.
    10.1111/j.1600-065X.2007.00487.x
  15. Oliveira, V.; Água-Doce, A.; Duarte, J.; Soares, M.P.; Graca, L.. "Regulatory T cell maintenance of dominant tolerance: Induction of tissue self-defense?". Transplant Immunology 17 1 (2006): 7-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748956936&partnerID=MN8TOARS.
    10.1016/j.trim.2006.09.028
  16. Sawitzki, B.; Kingsley, C.I.; Oliveira, V.; Karim, M.; Herber, M.; Wood, K.J.. "IFN-¿ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo". Journal of Experimental Medicine 201 12 (2005): 1925-1935. http://www.scopus.com/inward/record.url?eid=2-s2.0-22344434572&partnerID=MN8TOARS.
    10.1084/jem.20050419
  17. Vieira, Lui´s; Oliveira, Vanessa; Ambrósio, Ana P.; Marques, Bárbara; Pereira, Ana M.; Hagemeijer, Anne; Boavida, M.G.. "Translocation (8;17;15;21)(q22;q23;q15;q22) in acute myeloid leukemia (M2)". Cancer Genetics and Cytogenetics 128 2 (2001): 104-107. http://dx.doi.org/10.1016/s0165-4608(01)00404-6.
    10.1016/s0165-4608(01)00404-6

Intellectual property

Patent
  1. Oliveira, Vanessa. 2006. "SUPPRESSION OF TRANSPLANT REJECTION". United Kingdom.
    Expired
  2. Oliveira, Vanessa. 2004. "SUPPRESSION OF TRANSPLANT REJECTION". United Kingdom.
    Expired
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/10/07 “Flow cytometry in transplantation” Encontros de Gerações, "Gerações à conversa"
Ordem dos Médicos, (Lisboa, Porto e Coimbra, Portugal)
2018/06/13 A critical analysis of our experience as participants in an external quality assessment scheme for blood coagulation Clinical and Laboratory Haemostasis
NEQAS Coagulation (Sheffield, United Kingdom)
2018/03/20 Progenitor cell thresholds and hematopoietic engraftment in 900 autologous transplantations. Implications for quality control 44th Annual Meeting of the European Society for Blood and Marrow Transplantation
European Society for Blood and Marrow Transplantation (Lisboa, Portugal)
2017/11/16 Contagem de progenitores e enxerto hematopoiético em 900 transplantes autólogos. Implicações para o controle de qualidade Reunião Anual da Sociedade Portuguesa de Hematologia
Sociedade Portuguesa de Hematologia (Vilamoura, Portugal)
2017/07/10 Tolerance induction to recombinant FVIII in a model of hemophilia BHAP Awards Dinner and Ceremony, 2017
Bayer Global (Berlin, Germany)
2017/06/01 Benefícios após implementação de um protocolo de Patient Blood Management SETS-APIH
Associação Portuguesa de Imuno-hemoterapia (Porto, Portugal)
2017/05/05 Tolerance induction to recombinant FVIII in a model of hemophilia BHAP Alumni Global Webinar
BHAP Global
2017/05/04 Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10 redeSAÚDE 4th Annual Conference
Universidade de Lisboa (Lisboa, Portugal)
2016 Boosting dendritic cell function to facilitate tolerance induction to recombinant clotting factors BHAP Alumni Global Webminar
Bayer Global
2015/10/15 Boosting dendritic cell function to facilitate tolerance induction to recombinant clotting factors Bayer HealthCare Hematology Conference 2015
Bayer HealthCare (Dusseldorf, Germany)
2015/10/08 Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10 IX Congresso Nacional da Associação Portuguesa de Imuno-hemoterapia
Associação Portuguesa de Imuno-hemoterapia (Viseu, Portugal)
2012/10/13 Synergy between anti-CD4 mAb and adjuvant (alum) in the induction of immune tolerance using a model of haemophilia A Third International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases
(Shangai, China)
2008 Suboptimal conditions of TCR stimulation favour the induction of FoxP3+CD4+ cells XXXIV Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Porto, Portugal)
2006/09 CD62L+CD25+CD4+ regulatory T cells generated in vitro by anti-CD4 treatment express FoxP3 and can prevent rejection of allogeneic skin transplants 1st RCAI International Summer Program
RCAI (Yokohama, Japan)
2005 Treatment of CD4+ T cells with anti-CD4 in vitro induces the generation of cells capable of suppressing alloreactive responders in vitro and in vivo 3rd International Symposium on the clinical use of Cellular Products- Cellular Therapy
(Regensburg, Germany)
2005 Treatment of CD4+ T cells with anti-CD4 in vitro induces the generation of cells capable of suppressing alloreactive responders in vitro and in vivo Basic Sciences Symposium
(La Baule, France)
2003 Inhibition of mannosidase I in regulatory T cells reduces their potential to inhibit activation of naive CD4+ T cells British Transplantation Society Annual Meeting
British Transplantation Society (Londres, United Kingdom)
2003 Treatment of CD4+ T cells with anti-CD4 in vitro induces the generation of cells capable of suppressing alloreactive responders in vitro and in vivo Basic Sciences Symposium
British Transplantation Society (Keystone, United States)
2000 T cell mediated tolerance: Growth of regulatory CD25+ T cells depends on naïve CD25- T cells XXVI Reunion of the Portuguese Society of Immunology
Portuguese Society of Immunology (Porto, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016/11/25 - Current Noções básicas de "Patient Blood Management", PBM Otimização do doente cirúrgico e racionalização da transfusão
Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2016/11/04 - Current Revisão sobre critérios gerais de epidemiologia, diagnóstico e tratamento da insuficiência cardíaca
Other
 1º Curso de Actualização em Insuficiência Cardíaca
Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2016/06 - Current Noções gerais sobre a aplicabilidade de componentes sanguíneos Utilização de Componentes Sanguíneos
Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2016/06 - Current Noções gerais de fluidoterapia e sua aplicabilidade prática
Seminar
 Fluidoterapia
Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2016/03/03 - Current Breve descrição sobre os novos anticoagulantes orais com especial ênfase para o rivaroxabano
Symposium
 NOAC’s – O que esperar na prática clínica
Bayer Portugal SA, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/10/21 - 2020/10/21 “Protocolo de Transfusão Maciça”, Curso em Medicina Transfusional para Internos de Formação Geral Curso em Medicina Transfusional para Internos de Formação Geral (Especialização pós-licenciatura) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2017/05 - 2017/05 Transfusão de Concentrado de Plaquetas Medicina Transfusional para Internos de Especialidade e Internos de Ano Comum (Especialização pós-licenciatura) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2017/03 - 2017/03 Transfusão no Doente Crítico Sessão Clínica de Aprendizagem (Outros) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2017/02 - 2017/02 Transfusão em contexto de Urgência II Edição do Curso de Abordagem Prática do Doente Urgente (Especialização pós-licenciatura) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
2017/01/13 - 2017/01/13 Reversão do dabigatrano com anticorpo monoclonal Sessão de Formação para o Serviço de Anestesia do Hospital Professor Doutor Fernando Fonseca (Outros) Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Distinctions

Award

2015 1º Prémio Poster
Associação Portuguesa de Imuno-hemoterapia (APIH), Portugal

Other distinction

2011 Travel Grant
Sociedade Portuguesa de Imunologia, Portugal
2011 Early Career Investigator Award (to finance a project)
2006 Travel Grant
Keystone Symposia, United States
2006 RCAI 1st International Summer Program Scholarship
2005 Travel Grant
2004 Travel Grant
Keystone Symposia, United States
2003 BTS-Wyeth-Morris travelling fellowship 2003
British Transplantation Society, United Kingdom
2003 Travel Grant