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Andreia Gomes graduated in biochemistry in 2010 from Universidade de Trás-os-Montes e Alto Douro, Portugal, and completed her master in Biotechnology in 2012 from Faculdade de Ciências e Tecnologias ¿ Universidade Nova de Lisboa, Portugal. In 2021 Andreia completed her Ph.D in Molecular Biosciences from Instituto de Tecnologia Química e Biológia ¿ Universidade Nova de Lisboa, Portugal. She focused on the understanding of the molecular mechanisms underlying the beneficial effects of a (poly)phenol enriched diet in in vitro and in vivo cardiovascular models¿. Her work was awarded with an honorable mention in the category of Research and Development within Food & Nutrition Awards (FNA) 2019. Currently, Andreia is a postdoctoral researcher at the Translation Biology Laboratory at CBIOS-ULHT. From a total of 19 publications, 13 were published in the last 5 years, and they include 3 as first author. Andreia had 6 oral communications in scientific meetings (2 awarded as best oral communication) and 5 poster presentations in scientific meetings (2 awarded as best young poster communication). She integrated the management committee of 2 COST actions. Andreia offers proficiency in cell biology, particularly experience with different cell lines and primary cell culture techniques, and in different omics techniques: proteomics (2D-electrophoresis, Western blotting, size exclusion chromatography), metabolomics (UPLC MS/MS, NMR, 16s rRNA gene sequencing). Additionally, she has the FELASA Level C Course on Laboratory Animal Sciences. Works in the areas of Natural sciences with emphasis on Biological Sciences, and aims to help in the identification of molecular targets for therapeutic intervention and development of novel diagnostic tools for diabetes prevention and detection.
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Identification

Personal identification

Full name
Andreia Filipa dos Santos Gomes

Citation names

  • Gomes, Andreia

Author identifiers

Ciência ID
1D1E-DE66-DB38
ORCID iD
0000-0003-2605-2565

Addresses

  • Universidade Lusófona de Humanidades e Tecnologias, Escola de Ciências e Tecnologias da Saúde, Campo Grande 376, 1749-024, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/01/28
Concluded
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa, Portugal
"Disclosing the mechanisms underlying the beneficial effects of berries-driven polyphenols in in vitro, as well as in vivo cardiovascular models" (THESIS/DISSERTATION)
2012
Concluded
 Master in Biotechnology (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Proteomic analysis of a neurodegeneration cell model, treated with plant extracts with potential neuroprotective activity" (THESIS/DISSERTATION)
 16
2011
Concluded
 Biochemistry (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Synthesis, spectroscopic characterization and evaluation of squarylium cyanine dyes in a cell line proliferation HepG-2" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/09/11 - Current Contracted Researcher (Research) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2022/02/01 - 2023/09/10 Postdoc (Research) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2020/06/08 - 2022/01/31 Contracted Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/03/01 - 2020/04/30 Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/09/11 - Current Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Others

Category
Host institution 		Employer
2015/03/01 - 2019/02/28 PhD student (SFRH/BD/103155/2014) Instituto de Biologia Experimental e Tecnológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
(...)
2014/06/01 - 2015/02/28 Master Research Fellow Instituto de Biologia Experimental e Tecnológica, Portugal
2013/01/01 - 2014/05/31 MasterResearch Fellow Instituto de Biologia Experimental e Tecnológica, Portugal
Projects

Grant

Designation Funders
2019/07/01 - 2020/04/30 Nature Bioactive Food
PDR2020-101-031529
Master Student Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Concluded
2015/03/01 - 2019/06 Disclosing the mechanisms underlying the beneficial effects of berries-driven polyphenols in in vitro, as well as in vivo cardiovascular models
info:eu-repo/grantAgreement/FCT/3599-PPCDT/135793/PT
PhD Student Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/06/01 - 2015/02/28 Mechanisms of Cardioprotection by Berries-driven Polyphenols
FCT-ANR/BEX-BCM/0001/2013
Master Student Fellow
Concluded
2013/01/01 - 2014/05/31 EUBerry – The sustainable improvement of European berry production, quality and nutritional value in a changing environment: Strawberries, Currants, Blackberries and Raspberries
EUBerry FP7-KBBE-2010-265942
Master Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Concluded
Outputs

Publications

Journal article
  1. Farrim, Maria I.; Gomes, Andreia; Regina de A. Menezes; Milenkovic, Dragan. "Gene expression analysis reveals diabetes-related gene signatures". Human Genomics 18 16 (2024):
    Open access • Published • https://doi.org/10.1186/s40246-024-00582-z
  2. Rebelo, Maria; Tang, Cong; Coelho, Ana R; Labão-Almeida, Carlos; Schneider, Matthias M; Tatalick, Laurie; Ruivo, Pedro; et al. "De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection". The Journal of Infectious Diseases 228 6 (2023): 723-733. http://dx.doi.org/10.1093/infdis/jiad135.
    Open access • Published • 10.1093/infdis/jiad135
  3. Cruz-Machado, Ana Rita; Barreira, Sofia C.; Bandeira, Matilde; Veldhoen, Marc; Gomes, Andreia; Serrano, Marta; Duarte, Catarina; et al. "Risk Factors for Infection, Predictors of Severe Disease, and Antibody Response to COVID-19 in Patients With Inflammatory Rheumatic Diseases in Portugal—A Multicenter, Nationwide Study". Frontiers in Medicine 9 (2022): http://dx.doi.org/10.3389/fmed.2022.901817.
    10.3389/fmed.2022.901817
  4. Canto e Castro, Luísa; Gomes, Andreia; Serrano, Marta; Pereira, Ana Helena Guia; Ribeiro, Rita; Napoleão, Patrícia; Domingues, Inês; et al. "Longitudinal SARS-CoV-2 seroprevalence in Portugal and antibody maintenance 12 months after infection". European Journal of Immunology 52 1 (2021): 149-160. http://dx.doi.org/10.1002/eji.202149619.
    10.1002/eji.202149619
  5. Canto e Castro, Luísa; Pereira, Ana Helena Guia; Ribeiro, Rita; Alves, Catarina; Veloso, Luís; Vicente, Vera; Alves, Dalila; et al. "Prevalence of SARS-CoV-2 Antibodies after First 6 Months of COVID-19 Pandemic, Portugal". Emerging Infectious Diseases 27 11 (2021): 2878-2881. http://dx.doi.org/10.3201/eid2711.210636.
    Open access • Accepted • 10.3201/eid2711.210636
  6. Trombetta, Amelia C.; Farias, Guilherme B.; Gomes, André M. C.; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, Joel; et al. "Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype". Frontiers in Immunology 12 (2021): 2341. http://dx.doi.org/10.3389/fimmu.2021.691725.
    Open access • 10.3389/fimmu.2021.691725
  7. Miguel Esperança-Martins; Lisa Gonçalves; Inês Soares-Pinho; Gomes, Andreia; Marta Serrano; Birte Blankenhaus ; Patrícia Figueiredo-Campos; et al. "Humoral Immune Response of SARS-CoV-2–Infected Patients with Cancer: Influencing Factors and Mechanisms". The Oncologist 26 9 (2021): e1619-e1632. https://theoncologist.onlinelibrary.wiley.com/doi/10.1002/onco.13828.
    Open access • Published
  8. Figueiredo-Campos, Patrícia; Blankenhaus, Birte; Mota, Catarina; Gomes, Andreia; Serrano, Marta; Ariotti, Silvia; Costa, Catarina; et al. "Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset". European Journal of Immunology 50 12 (2020): 2025-2040. http://dx.doi.org/10.1002/eji.202048970.
    10.1002/eji.202048970
  9. Gomes, A.; Godinho-Pereira, J.; Oudot, C.; Sequeira, C.O.; Macià, A.; Carvalho, F.; Motilva, M.J.; et al. "Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats". Free Radical Biology and Medicine 154 (2020): 119-131. http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.002.
    10.1016/j.freeradbiomed.2020.05.002
  10. Ruskovska, Tatjana; Massaro, Marika; Carluccio, Maria Annunziata; Arola-Arnal, Anna; Muguerza, Begoña; Vanden Berghe, Wim; Declerck, Ken; et al. "Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease". Food & Function 11 6 (2020): 5040-5064. http://dx.doi.org/10.1039/d0fo00701c.
    10.1039/d0fo00701c
  11. Gomes; Oudot; Macià; Foito; Carregosa; Stewart; Van de Wiele; et al. "Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota". Nutrients 11 11 (2019): 2634. http://dx.doi.org/10.3390/nu11112634.
    10.3390/nu11112634
  12. Daniela Dias-Pedroso; Joel Guerra; Andreia Gomes; Carole Oudot; Catherine Brenner; Cláudia N. Santos; Helena L. A. Vieira. "Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol". Cardiovascular Toxicology 19 2 (2019): 156-167. https://doi.org/10.1007/s12012-018-9485-8.
    10.1007/s12012-018-9485-8
  13. Carole Oudot; Andreia Gomes; Valérie Nicolas; Morgane Le Gall; Philippe Chaffey; Cédric Broussard; Giuseppe Calamita; et al. "CSRP3 mediates polyphenols-induced cardioprotection in hypertension". The Journal of Nutritional Biochemistry 66 (2019): 29-42. https://doi.org/10.1016/j.jnutbio.2019.01.001.
    10.1016/j.jnutbio.2019.01.001
  14. Santos, C.N.; Gomes, A.; Oudot, C.; Dias-Pedroso, D.; Rodriguez-Mateos, A.; Vieira, H.L.A.; Brenner, C.. "Pure polyphenols applications for cardiac health and disease". Current Pharmaceutical Design 24 19 (2018): 2137-2156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054776733&partnerID=MN8TOARS.
    10.2174/1381612824666180608102344
  15. Gomes, A.; Pimpão, R.C.; Fortalezas, S.; Figueira, I.; Miguel, C.; Aguiar, C.; Salgueiro, L.; et al. "Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation". Industrial Crops and Products 74 (2015): 505-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930938252&partnerID=MN8TOARS.
    10.1016/j.indcrop.2015.04.037
  16. Gomes, Andreia. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson’s Disease". PLOS Genetics 10 5 (2014): e1004302. https://doi.org/10.1371/journal.pgen.1004302.
    Published
  17. Alminger, M.; Aura, A.-M.; Bohn, T.; Dufour, C.; El, S.N.; Gomes, A.; Karakaya, S.; et al. "In vitro models for studying secondary plant metabolite digestion and bioaccessibility". Comprehensive Reviews in Food Science and Food Safety 13 4 (2014): 413-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902975429&partnerID=MN8TOARS.
    10.1111/1541-4337.12081
  18. Tenreiro, Sandra; Reimao-Pinto, Madalena M.; Antas, Pedro; Rino, Jose; Wawrzycka, Donata; Macedo, Diana; Rosado-Ramos, Rita; et al. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLOS Genetics (2014): https://publons.com/wos-op/publon/6254382/.
    10.1371/JOURNAL.PGEN.1004302
  19. Gomes, Andreia. "Valuing the Endangered Species Antirrhinum lopesianum: Neuroprotective Activities and Strategies for in vitro Plant Propagation.". Antioxidants (2013):
    10.3390/antiox2040273
Magazine article
  1. Rosado-Ramos, Rita; Gomes, Andreia; Cláudia Nunes dos Santos. Corresponding author: Cláudia Nunes dos Santos. "Pequenos Frutos: Benefícios para a saúde em pequenas "embalagens"", Revista do Setor Agrário Voz do campo, 2017
  2. Gomes, Andreia; Rosado-Ramos, Rita; Cláudia Nunes dos Santos. Corresponding author: Cláudia Nunes dos Santos. "Efeitos benéficos dos polifenóis nas doenças cardiovasculares", Revista técnico-científica agrícola AGROTEC - Suplemento Pequenos Frutos , 2017
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/17 Análise integrada das alterações transcriptómicas associadas à diabetes: novas pistas para transdiferenciação de células pancreáticas 19º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2019/10/04 Beneficial effects of a berry-enriched diet in hypertensive rats: metabolic fate of (poly)phenols and the role of gut microbiota NutRedOx COST Action CA16112 Meeting
(Lisboa, Portugal)
2018/09/28 Beneficial effects of (poly)phenols in an animal model of hypertension: exploring the role of gut microbiota 2nd International Conference in Food Bioactives and Health
(Lisboa, Portugal)
2017/09/27 Daily consumption of a (poly)phenol enriched diet prevents death of hypertensive rats: exploring the role of gut microbiota. NutRedOx COST Action CA16112 & the 6th NutriOx Atelier 2017
(Strasburg, France)
2017/02/02 We are what we eat! Beneficial effects of polyphenols in cardiovascular diseases JorTec – Jornadas Tecnol gicas da Faculdade de Ci ncias e Tecnologia da Universidade Nova de Lisboa
(Almada, Portugal)
2016/10/15 Beneficial effects of a berries mixture in an animal model of hypertension V Colóquio Nacional de Pequenos Frutos
(Oeiras, Portugal)
2014/06/05 Daily Polyphenols intake from fresh fruits in Portugal 8th ISANH Congress on Polyphenols Applications
2013/10/09 In vitro models for studying secondary plant metabolite digestion and bioaccessibility 4th MC & WG Meeting INFOGEST Cost Action
(Izmir, Turkey)
2013/02/27 Portuguese endemic plant species: characterization of phenolics compounds, bioactivities and strategies for plant in vitro propagation, Workshop Plant Natural Products & Biotechnology
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/03/01 - Current Targeting ß-cell dysfunction as a therapeutic strategy for diabetes: a multi-omics approach
Co-supervisor of Maria Inês Farrim
 Health Sciences (PhD)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2022/03/01 - 2022/09/30 Potenciais propriedades antidiabéticas dos polifenóis presentes no bagaço da uva: uma revisão bibliográfica
Co-supervisor
 Nutritional Sciences (Degree)
Universidade Lusófona de Humanidades e Tecnologias, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/10 - 2019/10 Part of the Organizing Committee of the Training School on “Food metabolites and the impact of microbiota” held in Lisbon (October 2019) sponsored by the COST Action NutRedOx. (2019/10 - 2019/10)
Workshop (Member of the Organising Committee)
2018/09/26 - 2018/09/28 Part of the Organizing Committee of 2nd International Conference in Food Bioactives and Health, held in Lisbon, Portugal, September 26th to 28th, 2018. (2018/09/26 - 2018/09/28)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/04/20 - 2023/04/23 Poster presentation: Pancreatic islet cell reprogramming into insulin producers: a multi-omics approach
Congress
 American Physiology Summit
2022/12/05 - 2022/12/08 Poster presentation: A glimpse into the potential impact of diabetes care on mental health and wellness.
Congress
 International Diabetes Foundation
2022/11/17 - 2022/11/18 Poster presentation: Polifenóis como agentes de combate à disfunção das células ßpancreáticas: do efeito anti-amiloidogénico do IAPP à transdiferenciação celular
Congress
 4º Congresso Nacional APDP
Associação Protetora dos Diabéticos de Portugal, Portugal
2022/07/07 - 2022/07/07 A Microbiota e Saúde Humana
Symposium
 A Microbiota e Saúde Humana
Instituto Gulbenkian de Ciência, Portugal
2017/05/04 - 2017/05/05 Poster presentation: A (poly)phenol enriched diet prevents death of hypertensive rats: role of gut microbiota
Congress
 XVI Congresso de Nutrição e Alimentação
2016/11/23 - 2016/11/25 Poster presentation: Beneficial effects of (poly)phenols in a rat model of hypertension: does microbiota play a role?
Meeting
 7th ITQB PhD Students Meeting
2016/09/13 - 2016/09/15 Poster presentation: Beneficial effects of (poly)phenols in an animal model of hypertension: the role of gut microbiota
Conference
 1st International Conference on Food Bioactives & Health held in Norwich
2016/09/05 - 2016/09/09 Poster presentation: Metabolic fate of (poly)phenols in a rat model of hypertension: does the microbiota play a role?
Workshop
 II Summer School on Nutrigenomics, Camerino, Italy
2016/03/15 - 2016/03/17 Poster presentation: Unveiling the polyphenols metabolites underlying mechanisms responsible for their beneficial effect against hypertension
Meeting
 3rd WG Meeting COST Action POSITIVe, Bucarest, Romenia
2015/10/27 - 2015/10/30 Poster presentation: Identification of polyphenol metabolites in Dahl salt-sensitive hypertensive rat tissues after a sustained daily intake of a cardioprotective berries mixture
Congress
 International Conference on Polyphenols and Health, Tours, France,
2014/06/12 - 2014/06/13 Poster presentation: Mechanisms of Cardioprotection by Berries Driven Polyphenols
Conference
 14th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants
2012/04/20 - 2012/04/21 Poster presentation: O efeito das amoras no padrão das proteínas em células humanas
Meeting
 IV Colóquio Nacional da Produçãoo de Pequenos Frutos, Faro
2010/12/15 - 2010/12/17 Poster presentation: Evaluation of the effect of squarylium cyanine dyes on the proliferation and viability of HepG-2 cells in culture
Congress
 XVII Congresso Nacional de Bioquímica, Porto

Committee member

Activity description
Role 		Institution / Organization
2017 - 2020 Manage Committee of the COST Action CA16112 - Personalized Nutrition in aging society: redox control of major age-related diseases (NutRedOx)
2014 - 2018 Manage committee substitute at the COST Action FA1403 - Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe)
Member
2013 - 2015 Early Stage Researcher participating in working group 2 of the COST ActionFA1005 - Improving health properties of food by sharing our knowledge on the digestive process (INFOGEST)
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/10 - 2019/10 Invited to give a practical class (hands-on) on 16S rRNA gene sequencing data analysis - NutRedOx COST Action CA16112 Meeting at Universidade Lus fona de Humanidades e Tecnologias (Outros)
2017/10/09 - 2017/10/13 Theoretical and practical course about "Basic principles of cell culture" to MSc students at the Molecular Nutrition and Health Laboratory at iBET. (Outros)
2015/10 - 2015/10 Invited to teach one lesson about Proteomic analysis for the degree “Qualidade Alimentar e Nutrição Humana” from the Escola Superior de Agronomia – Instituto Politécnico de Santarém (Licenciatura) Instituto Politécnico de Santarém Escola Superior Agrária, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/01/14 Interview regarding the honorable mention obtained in the category of Research and Development within Food & Nutrition Awards 2019 for the project “Poly4Hiper - (Poly)phenols beneficial effects in hypertension” O Jornal Económico

Mentoring / Tutoring

Topic Student name
2014/09 - 2015/10 Berries driven (poly)phenols-induced cytoprotection in cardiomyocytes Joel Guerra
2013/09 - 2014/10 Polyphenols neuroprotective effect in a Parkinson's disease yeast model: Phosphoproteome alterations Vitor Gonçalves
Distinctions

Award

2020 Honorable mention in the category of Research and Development within Food & Nutrition Awards 2019 for the project “Poly4Hiper - (Poly)phenols beneficial effects in hypertension”
2019 Best Oral Communication at the NutRedOx COST Action CA16112 Meeting - “Beneficial effects of a berry-enriched diet in hypertensive rats: metabolic fate of (poly)phenols and the role of gut microbiota”
2017 Best Oral Communication at the NutRedOx COST Action CA16112 & Postgraduate Training Atelier "NutriOx" - “Daily consumption of a (poly)phenol enriched diet prevents death of hypertensive rats: exploring the role of gut microbiota”
2016 Young Investigators Poster Award in the II Summer School on Nutrigenomics - “Metabolic fate of (poly)phenols in a rat model of hypertension: does the microbiota play a role?”
2015 Young Investigators Poster Award in the 7th International Conference on Polyphenols and Health - Identification of polyphenol metabolites in Dahl salt-sensitive hypertensive rat tissues after a sustained daily intake of a cardioprotective berries mixture”

Other distinction

2017 Scholarship to participate in the training school "Use of Nutrigenetics and Nutri(Epi)genomics in Nutrition Research"
2013 Scholarship to participate in the PhD Training School entitled "Food Digestion and Human Health"