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Miguel Lino holds a MSc degree in Biomedical Engineering (Instituto Superior Técnico, University of Lisbon) and a PhD in Biosciences, Specialization in Biotechnology from the University of Coimbra (2017). Currently, he is a postdoctoral researcher in the Biomaterials and Stem Cell Based Therapeutics Group at CIBB, working in the area of nanobiotechnology and biomaterials for regenerative medicine purposes. During his PhD, he made significant contributions in the field of drug delivery. He was mostly involved in the development of light-triggerable nanoformulations for intracellular delivery of biomolecules with spatial and temporal control for modulation of cell activity. The work was developed within the scope of an ERC funded project (ERC Grant Agreement nº 307384). The results of his PhD work were the first report on spatiotemporal control of multiple biomolecule release from the same nanocarrier. Since 2017, as a post-doctoral researcher, he is working in a project that aims to better understand cardiovascular ageing and to develop therapies for cardiovascular/brain disorders. He has been particularly focused in the development of advanced extracellular vesicle based-therapies for the treatment of brain ischemia. Since 2019, he is also participating in collaborative projects with Professor Costanza Emanuelli (Imperial College, UK) within the scope of CardioRNA CostAction, Dr. Tomas Sobrino (Univ. Santiago Compostela) in the Interreg project Neuroatalantic, and Dr. Marina Resmini (Univ. Queen Mary, London) in the Marie Curie ITN project NanoStem. He is/was team member of 6 national and international projects (>5M €) funded by a diversity of agencies (e.g. FCT, European Commission). Over the years, Miguel mentored 5 visiting students and 2 research fellows and is presently supervising a team of 5 researchers (1 postdoctoral researcher, 1 PhD student and 3 MSc fellows) dedicated to brain targeting therapies. Overall he published 11 articles in high impact peer-reviewed journals, including Nanoscale, Biomaterials and ACS Nano and he has one international patent. Miguel Lino has co-organized 7 conferences/scientific meetings. Since 2019, he is the coordinator of the section Cell Therapies and Tissue Engineering of the Portuguese Society for Stem Cells and Cell Therapies
Identification

Personal identification

Full name
Miguel Maria da Fonseca Miranda Ferreira Lino

Citation names

  • Lino, Miguel

Author identifiers

Ciência ID
1C1F-4287-AF90
ORCID iD
0000-0001-6011-0058

Knowledge fields

  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2017
Concluded
PhD in Biosciences, Specialization in biotechnology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Light-triggerable Nanomaterials for the Delivery of Biomolecules" (THESIS/DISSERTATION)
Approved with praise and distinction
2007
Concluded
Integrated Masters in Biomedical Engineering (Mestrado)
Universidade de Lisboa, Portugal
"Análise ecográfica, estrutural e biomecânica de tendões" (THESIS/DISSERTATION)
17
Affiliation

Science

Category
Host institution
Employer
2021/06/01 - Current Invited Auxiliary Researcher (Research) Faculty of Medicine of the University of Coimbra, Portugal
2021/08/01 - 2021/09/25 Visiting Researcher (Research) Faculty of Medicine of the University of Coimbra, Portugal
Imperial College London - Hammersmith Campus, United Kingdom
2018/10/01 - 2021/03/31 Contracted Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Others

Category
Host institution
Employer
2017/11/01 - 2018/09/30 Post-doctoral researcher (project ERA@UC) CNC.IBILI, Portugal
2016/02/01 - 2017/10/31 Research assistant (project Nanotrigger ERC Grant Agreement nº 307384) CNC.IBILI, Portugal
2012/01/01 - 2017/06/20 PhD student (Doctoral program in Biosciences, Specialization in biotechnology) Universidade de Coimbra, Portugal
2009/09/01 - 2011/12/31 Research assistant. Development of antimicrobial nanomaterials and coatings for biomedical application Matera Lda, Portugal
Projects

Grant

Designation Funders
2017 - 2018/09/30 ERA@UC. Ref 669088. ERA Chair in Cellular and Molecular Biology of Ageing
Ref 669088
Post-doc Fellow
European Commission

Contract

Designation Funders
2018 - Current EXO-HEART: Protecção e regeneração cardíaca mediada pela administração sistémica e direcionada de exosomas.
PTDC/BTM-SAL/29919/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018 - Current A light-activatable nanoparticle library for the delivery of RNA-based therapies
PTDC/EQU-EQU/29414/2017
Post-doc
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019 Plataformas terapêuticas para acidentes vasculares cerebrais
SII&DT 3386 StrokeTherapy
Researcher

Other

Designation Funders
2012 - 2017/06/20 Triggerable nanomaterials to modulate cell activity
307384
PhD Student Fellow
CNC.IBILI, Portugal
European Research Council
2010 - 2012 Antimicrobial coatings and materials based in polycationic polymers
0000
Researcher
IAPMEI
Outputs

Publications

Conference paper
  1. Lino, Miguel. "Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel". Paper presented in ESCI 2019, 2019.
Conference poster
  1. Lino, Miguel. "Lignt-controlled systems for the delivery of microRNAs". Paper presented in 4th COST Action CardioRNA MC and WG Meeting, 2020.
  2. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Lino Ferreira. "Near-infrared triggered release of miRNAs for modulation of cell activity". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  3. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Henriques-Antunes; Alessandra Zonari; Lino Ferreira. "Spatio-temporal controlled delivery of miRNAs for modulation of angiogenic activity". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  4. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of cell activity by light-controlled delivery of miRNAS". Paper presented in 6th China-Europe Symposium on Biomaterials and Regenerative Medicine, 2017.
  5. Miguel Lino. "Light-controlled release of proteins from gold nanorods". Paper presented in 3rd Symposium in Nanoscience and Biomedical Nanotechnology, 2016.
Journal article
  1. Ricardo C. Abreu; Cristiana V. Ramos; Clarissa Becher; Miguel Lino; Carlos Jesus; Paula A. Costa Martins; Patrícia A. T. Martins; et al. "Exogenous loading of miRNAs into small extracellular vesicles". Journal of Extracellular Vesicles 10 10 (2021): https://doi.org/10.1002%2Fjev2.12111.
    10.1002/jev2.12111
  2. Sara Bernardo-Castro; Inês Albino; Ángela María Barrera-Sandoval; Francesca Tomatis; João André Sousa; Emanuel Martins; Susana Simões; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. https://doi.org/10.3390%2Flife11060482.
    10.3390/life11060482
  3. Lino, Miguel; Susana Simões; Francesca Tomatis; Inês Albino; Angela Barrera; Denis Vivien; Tomas Sobrino; Lino Ferreira. "Extracellular vesicles (EV) as brain therapeutics: a bioengineering perspective". Science Advances (2021):
    Submitted
  4. Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Lino, Miguel; Tiago Rondão; Artur Paiva; Lino Ferreira. "Antimicrobial peptide-tether dressing able to enhance wound healing by tissue contact". Biomaterials (2021):
    Under revision
  5. Francisco, Vitor; Lino, Miguel; Ferreira, Lino. "A near infrared light-triggerable modular formulation for the delivery of small biomolecules". Journal of Nanobiotechnology 17 1 (2019): http://dx.doi.org/10.1186/s12951-019-0530-y.
    10.1186/s12951-019-0530-y
  6. Helena Henriques-Antunes; Renato M. S. Cardoso; Alessandra Zonari; Joana Correia; Ermelindo C. Leal; Adrián Jiménez-Balsa; Miguel M. Lino; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano (2019): https://doi.org/10.1021/acsnano.9b00376.
    10.1021/acsnano.9b00376
  7. Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. https://doi.org/10.1039/C9NR02512J.
    10.1039/C9NR02512J
  8. Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers". ACS Nano (2018): https://doi.org/10.1021/acsnano.7b07538.
    10.1021/acsnano.7b07538
  9. Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira. "Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules". Bioconjugate Chemistry (2018): https://doi.org/10.1021%2Facs.bioconjchem.7b00820.
    10.1021/acs.bioconjchem.7b00820
  10. Miguel M. Lino; Lino Ferreira. "Light-triggerable formulations for the intracellular controlled release of biomolecules". Drug Discovery Today (2018): https://doi.org/10.1016%2Fj.drudis.2018.01.019.
    10.1016/j.drudis.2018.01.019
  11. Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira. "Intracellular delivery of more than one protein with spatio-temporal control". Nanoscale (2017): https://doi.org/10.1039/C7NR02414B.
    10.1039/C7NR02414B
  12. Miguel M. Lino; Cristiana S.O. Paulo; Ana C. Vale; M. Fátima Vaz; Lino S. Ferreira. "Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles". Dental Materials 29 10 (2013): e252-e262. https://doi.org/10.1016%2Fj.dental.2013.07.023.
    10.1016/j.dental.2013.07.023
  13. Lino, Miguel. "Differential internalization of amphotericin B – Conjugated nanoparticles in human cells and the expression of heat shock protein 70". Biomaterials 34 21 (2013): 5281-5293. http://www.sciencedirect.com/science/article/pii/S014296121300358X.
    https://doi.org/10.1016/j.biomaterials.2013.03.048
  14. D. Botequim; J. Maia; M. M. F. Lino; L. M. F. Lopes; P. N. Simões; L. M. Ilharco; L. Ferreira. "Nanoparticles and Surfaces Presenting Antifungal, Antibacterial and Antiviral Properties". Langmuir 28 20 (2012): 7646-7656. https://doi.org/10.1021%2Fla300948n.
    10.1021/la300948n
Thesis / Dissertation
  1. Lino, Miguel. "Light-triggerable nanomaterials for the delivery of biomolecules". PhD, Universidade de Coimbra, 2017.

Intellectual property

Patent
  1. Lino, Miguel. 2017. "composition for controlled release of a biomolecule, method of preparation and uses thereof". Portugal.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/07 Advanced formulations for the delivery of biomolecules 2nd NanoStem Summer School
University of Coimbra (Coimbra, Portugal)
2019/12 Modulation of microRNA Delivery with Light CiBB meeting 2019
CiBB (Coimbra, Portugal)
2019/07 Controlled release of small extracellular vesicles by a light-triggerable hydrogel improves diabetic wound healing Controlled Release Society, Annual Meeting and Exposition
CRS (Valência, Spain)
2019/05 Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/05 What is needed from preclinical research to set up a clinical trial 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/05 PET imaging and in vivo biodistribution of small extracellular vesicles 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/01/19 Controlled drug release systems Advanced workshop on biotechnology
Instituto de Educação e Cidadania (Portugal)
2018/12 Improved wound healing activity of small extracellular vesicles loaded in a light-triggerable hydrogel Secretome Without Borders
(Braga, Portugal)
2018 Controlling drug delivery with light IV Symposium of the Doctoral Program on Molecular and Environmental Biology,
(Braga, Portugal)
2016/07 Light controlled protein delivery German-Portuguese Student Workshop within the DAAD-Programme “Dialogue with Institutions of Higher Education in Southern Europe”
Biomaterials and Stem Cell based therapeutics Lab (Cantanhede, Portugal)
2016/05 Modulating protein delivery by opto-nanomedicine 10th World Biomaterials Congress,
(Montreal, Canada)
2015/10 Modulating cell activity by opto-nanomedicine 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
(Oeiras, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/11 - Current Neuroregenerative properties of extracellular vesicles
Supervisor of Inês Aires
2019/03 - Current Engineered formulations for brain gene editing
Co-supervisor of Angela Barrera
Universidade de Coimbra, Portugal
2018/09/01 - Current New platforms for brain targeting by extracellular vesicles
Co-supervisor of Inês Maria Cunha Albino
Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2016/06/27 - Current Stem cell workshop: from basic research to clinical applications, Centro Hospitalar da Universidade de Coimbra, Portugal, June 27 th 2016. (2016/06/27)
Workshop (Member of the Organising Committee)
2014/03 - Current Workshop on Stem cells: from basic research to therapeutic applications, Centro do Sangue e Transplantação de Coimbra, Coimbra, Portugal, March 24 th , 2014. (2014/03/24)
Workshop (Co-organisor)
2013/12 - Current German-Portuguese student Workshop on “Matrix Engineering meets Stem Cell Therapy”, Biocant, Cantanhede, Portugal, December 2013. (2013/12)
Workshop (Co-organisor)
2013/07/19 - Current First International Conference on Stem Cells for Drug Screening and Regenerative Medicine, Biocant, Cantanhede, Portugal, July 19 th , 2013. The meeting had the contribution of renowned speakers including Jeffrey Karp (Harvard University), Molly Stevens (Imperial College of London), Pedro Granja (INEB, University of Porto, Portugal), Stephen Minger (GE Healthcare, UK), Tim Allsop (Pfizer), Joaquim Cabral (IST, Portugal), Constanza Emanueli (University of Bristol), Marc Peschanski (I-STEM) and Ihor Lemischka (Mount Sinai School of Medicine). (2013/07/19)
2019/06/28 - 2019/06/29 Conference: Ageing, models mechanisms and therapies. Responsible for the dissemination of the event in the media. (2019/06/28 - 2019/06/29)
Conference (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2018/07/27 - 2018/07/27 Workshop on “Ageing: models and therapies”, Faculty of Medicine, University of Coimbra, Polo III, June 27 th , 2018. (2018/07/27)
Workshop (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2016/07/07 - 2016/07/08 German-Portuguese student Workshop on “Translation in Biomaterials and Stem Cell Research”, Biocant, Cantanhede, Portugal, July 7-8 2016. The event was organized in collaboration with Dr. Tilo Pompe from the University of Leipzig, Germany, and funded by the DAAD program “Dialogue with Institutions of Higher Education in Southern Europe”. (2016/07/07 - 2016/07/08)
Workshop
Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2016/07/18 - 2016/07/22 Building Global innovators (Innovation accelerator) – Entrepreneurship course
Other
Building Global Innovators
ISCTE Business School, Portugal
2015/10/05 - 2015/10/09 Quantitative Fluorescence Microscopy Course
Workshop
Quantitative Fluorescence Microscopy Course
CNC.IBILI, Portugal
2009/11/02 - 2009/11/07 7th International Stem Cell School in Regenerative Medicine
Workshop

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/01/11 Biocompatible Nanoparticles to Modulate Cell Activity
(Thesis) Arguer
Josephine Blersch (PhD)
Universidade de Coimbra, Portugal
2018/12 Funcionalização de filmes finos plasmónicos de Au-TiO2 com elementos de bioreconhecimento para deteção de biomoléculas
(Thesis) Main arguer
Diana Isabela Faria Meira (Master)
Universidade do Minho, Portugal
2018/12 Development of ZnO thin films for antimicrobial applications
(Thesis) Main arguer
Patrícia Alexandra Pereira da Silva (Master)
Universidade do Minho, Portugal

Association member

Society Organization name Role
2017/10 - Current Controlled Release Society

Committee member

Activity description
Role
Institution / Organization
2019/07 - Current Coordinator of the section Stem Cells and Tissue Engineering
Coordinator

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/09/01 - Current Regenerative Medicine Ciências de Engenharia Biomédica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/01/12 - 2019/03/16 Biotechnology and Regenerative Medicine (Outros) Instituto de Educação e Cidadania, Portugal

Interview (tv / radio show)

Program Topic
2019/01/29 - 2019/01/29 Rádio França Internacional - Magazine de Ciência

Mentoring / Tutoring

Topic Student name
2021/01/01 - Current Production and characterization of extracellular vesicles João Novo (MSc fellow)
2018/01/01 - Current Extracellular vesicles to treat brain ischemia Tiago Rondão (MSc fellow)
2020/07/01 - 2020/09/30 Functionalization of gold nanorods Natália Ferrari (MSc student)
2020/05/01 - 2020/09/30 Production of extracellular vesicles Clarissa Becher (MSc fellow)
2019/09/01 - 2020/03/31 Extracellular vesicles for the treatment of ischemic stroke Inês Morais
2020/01 - 2020/02 Cell culture; extracellular vesicle isolation and characterization Diana Pereira Gonçalves (Undergraduate student)
2019/09/01 - 2019/10/01 Modification of extracellular vesicles with targeting peptides Francesco Catapano (Postdoctoral researcher)
2018/05/01 - 2018/05/31 Exosome isolation, characterization and modification strategies Luís Oliveira (MSc student)
Distinctions

Award

2017 Best Poster Prize
CESB, Portugal
2017 Best Poster Prize
Sociedade Portuguesa de Células Estaminais e Terapias Celulares, Portugal

Other distinction

2021 Short term scientific mission
COST, European Cooperation in Science and Technology, Belgium
2011 PhD scholarship (sfrh/bd/81705/2011)
Fundação para a Ciência e a Tecnologia, Portugal
2009 Travel grant - 7th International Stem Cell School in Regenerative Medicine
European Union Marie Curie Conferences and Training Courses, Belgium