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Catarina is currently immersed in her doctoral journey in the Central Nervous System, Blood and Peripheral Inflammation laboratory headed by Professor Adelaide Fernandes. She started her PhD degree at the Faculty of Pharmacy University of Lisbon (FFULisboa) in 2022. Since her master studies, Catarina was focused on exploring how blocking the action of an inflammatory molecule could prevent multiple sclerosis-associated pathogenesis using in vivo models. Afterwards, from 2018 to 2021, Catarina continued the studies as a Research Fellow of the project Grant for Multiple Sclerosis Innovation by Merck Serono to Professor Fernandes. In 2021, she received her PhD grant focused on the understanding of biological mechanisms underlying innate and adaptive immune interactions and their impact on MS progression. Also, she is interested to go a step further and fulfil the gap about the far-reaching effects of viral infections in these interactions and consequent MS progression. This work is being developed using innovative 3D cellular systems derived from induced pluripotent stem cells (IPSCs). In addition to her research project, Catarina is also member of the iMed.ULisboa PhD Students’ Commission (iPSCs) contributing to the academic community.
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Identification

Personal identification

Full name
Catarina Barros
Date of birth
1995/09/04
Gender
Female

Citation names

  • Barros, Catarina

Author identifiers

Ciência ID
1C1A-104D-D556
ORCID iD
0000-0002-5718-7246
Scopus Author Id
7102247049

Email addresses

  • catarinabarros@campus.ul.pt (Professional)
  • catarinabarros@campus.ul.pt (Professional)

Addresses

  • Avenida Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2022/01/01 - 2025/12/31
Ongoing
 Farmácia (Doutoramento)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
"“Deciphering the role of microglia-T cells interplay upon viral infection: impact in Multiple Sclerosis progression”" (THESIS/DISSERTATION)
2020/01 - 2020/02
Concluded
 International English Language Testing System (Outros)
British Council Portugal, Portugal
 B2
2018/03 - 2018/09
Concluded
 Laboratory Animal Science for Function A, certified by FELASA for Category B (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018
Concluded
 Biopharmaceutical Sciences (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Target S100B to reduce Experimental Autoimmune Encephalomyelitis pathogenesis" (THESIS/DISSERTATION)
 174
2016
Concluded
 Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Production of recombinant protein to develop polyclonal antibodies." (THESIS/DISSERTATION)
 134
Affiliation

Science

Category
Host institution 		Employer
2019/01/02 - 2021/12/31 Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/09 - 2018/11 Research Trainee (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016/01 - 2016/06 Research Trainee (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Projects

Grant

Designation Funders
2019/01/01 - 2021/12/31 Targeting multiple sclerosis immune- and psycho-pathophysiology by modulation of neuroinflammation
GMSI2017
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Merck KGaA
Ongoing

Contract

Designation Funders
2022/01/01 - 2024/12/31 Interplay between innate and acquired immune response at the basis for Multiple Sclerosis cognitive deficits
PTDC/MED-PAT/2582/2021
10.54499/PTDC/MED-PAT/2582/2021
Universidade do Minho, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 Interplay between innate and acquired immune response at the basis for Multiple Sclerosis cognitive deficits
PTDC/MED-PAT/2582/2021
10.54499/PTDC/MED-PAT/2582/2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Barros, Catarina; Alberro, Ainhoa; Fernandes, Adelaide. "Tackling the role of microglia in Multiple Sclerosis-associated cognitive impairment". Paper presented in XVI European Meeting on Glial Cells in Health and Disease, Berlin, 2023.
    Published • 10.1002/glia.24418
  2. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B plays an active role in the pathogenesis of the in vivo model of Multiple Sclerosis". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019.
    10.1002/glia.23675
  3. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Target S100B prevents in vivo MS-like pathology". Paper presented in 5th International Porto Congress of Multiple Sclerosis, Portugal, 2019.
    Published • 10.1007/s40120-019-0135-2
  4. Barateiro, Andreia; Barros, Catarina; Soromenho, Beatriz; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B has a crucial role in neuroinflammation and immune response in the in vivo model of Multiple Sclerosis". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences, Lisboa, 2019.
    10.3389/conf.fncel.2019.01.00052
  5. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Inhibition of S100B prevents ex vivo demyelination and improves EAE clinical score". 2018.
    10.1016/j.freeradbiomed.2018.04.504
  6. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B blockage prevents ex vivo demyelination and ameliorates EAE clinical score". Paper presented in Spring Reunion of the Portuguese Multiple Sclerosis Group, Coimbra, 2018.
Conference poster
  1. Barros, Catarina; Vaz Pinto, Maria; Costa, Inês; Fernandes, Adelaide. "Microglia derived from human PBMCs as a model to improve the study and characterization of Multiple Sclerosis". Paper presented in FENS Regional Meeting, 2023.
  2. Barros, Catarina; Vaz Pinto, Maria; Costa, Inês; Fernandes, Adelaide. "The use of PBMCs-derived microglia to study demyelination-associated mechanisms in Multiple Sclerosis". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  3. Barros, Catarina; Alberro, Ainhoa; Fernandes, Adelaide. "Addressing the Role of Microglia in Multiple Sclerosis-Associated Cognitive Impairment". Paper presented in V Symposium of the Portuguese Glial Network, 2022.
  4. Barros, Catarina; Alberro, Ainhoa; Fernandes, Adelaide. "Tackling microglia morphological changes in Multiple Sclerosis.". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  5. Ribeiro AR; Barros, Catarina; VazPinto, Maria; Leitão M; Alberro, Ainhoa; Barateiro, Andreia; Susan E Howllet; Fernandes, Adelaide. "Vamos desmistificar a Esclerose Múltipla". Paper presented in 1ª Edição Jornadas Científicas da Universidade de Lisboa, 2022.
  6. Barros, Catarina; Barateiro, Andreia; Basto, Afonso P; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B neutralization modulated Multiple Sclerosis-like pathogenesis.". Paper presented in iMed.ULisboa Meeting, 2021.
  7. Barros, Catarina; Barateiro, Andreia; Bastos, Afonso P; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B neutralization modulates T cells immune response in the in vivo model of Multiple Sclerosis". Paper presented in Conte Center Symposium on Neuro-Immune Interactions, 2021.
  8. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B as a crucial player in Multiple Sclerosis neuroinflammation and immunopathogenesis". Paper presented in 5th PhD Students Meeting of the Mind-Brain College of the Universidade de Lisboa, 2019.
  9. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B plays an active role in the pathogenesis of the in vivo model of Multiple Sclerosis". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  10. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B Specific Inhibition Prevents CNS Damage and Inflammation in the in vivo model of Multiple Sclerosis". Paper presented in 11th iMed.ULisboa Postgraduate Students’ Meeting & 4th i3DU Meeting, 2019.
  11. Barateiro, Andreia; Barros, Catarina; Soromenho, Beatriz; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B has a crucial role in inflammation and immune response in the in vivo model of Multiple Sclerosis". Paper presented in XVI Meeting of the Portuguese Society for Neurosciences, 2019.
  12. Barros, Catarina; Barateiro, Andreia; Soromenho, Beatriz; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B targeting change the inflammatory and imune profile of the in vivo model of Multiple Sclerosis". Paper presented in IV Symposium of the Portuguese Glial Network, 2019.
  13. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Role of astroglial-derived S100B during demyelination of the Multiple Sclerosis in vivo EAE model". Paper presented in IV Symposium of the Portuguese Glial Network, 2019.
  14. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Blockade of S100B prevents MS-associated pathogenesis in EAE model". Paper presented in 4th PhD Students Meeting of the Mind-Brain College of the Universidade de Lisboa, 2018.
  15. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Targeting S100B reduces demyelination-associated pathogenesis in ex vivo and in vivo models mimicking Multiple Sclerosis". Paper presented in 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2018.
  16. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B targeting prevents ex vivo demyelination and reduce EAE severity". Paper presented in 10th iMed.ULisboa Postgraduate Students’ Meeting & 3rd i3DU Meeting, 2018.
  17. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "Inhibition of S100B prevents ex vivo demyelination and improves EAE clinical score". Paper presented in 19th Biennial Meeting for the Society for Free Radical Research International (SFRRI), 2018.
Journal article
  1. Barateiro, Andreia; Barros, Catarina; Pinto, Maria V.; Ribeiro, Ana Rita; Alberro, Ainhoa; Fernandes, Adelaide. "Women in the field of multiple sclerosis: How they contributed to paradigm shifts". Frontiers in Molecular Neuroscience 16 (2023): http://dx.doi.org/10.3389/fnmol.2023.1087745.
    10.3389/fnmol.2023.1087745
  2. Barros, Catarina; Barateiro, Andreia; Neto, Alexandre; Soromenho, Beatriz; Bastos, Afonso P; Mateus, Joana M; Xapelli, Sara; et al. "S100B inhibition protects from chronic experimental autoimmune encephalomyelitis". Brain Communications (2022): http://dx.doi.org/10.1093/braincomms/fcac076.
    10.1093/braincomms/fcac076
  3. Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
    10.3390/cells10113163
  4. Ribeiro, Ana Rita; Barros, Catarina; Barateiro, Andreia; Howlett, Susan E; Fernandes, Adelaide. "Improved assessment of overall health in variably aged murine models of Multiple Sclerosis with a novel frailty index tool". The Journals of Gerontology: Series A (2021): http://dx.doi.org/10.1093/gerona/glab185.
    10.1093/gerona/glab185
  5. Barros, Catarina; Fernandes, Adelaide. "Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools". Multiple Sclerosis and Related Disorders 47 (2021): 102622. http://dx.doi.org/10.1016/j.msard.2020.102622.
    Published • 10.1016/j.msard.2020.102622
  6. das Neves, Sofia P.; Santos, Gisela; Barros, Catarina; Pereira, Diana Rodrigues; Ferreira, Ricardo; Mota, Cristina; Monteiro, Susana; et al. "Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms". Journal of Neuroimmunology 340 (2020): 577163. http://dx.doi.org/10.1016/j.jneuroim.2020.577163.
    Published
Magazine article
  1. Barros, Catarina. "Para além do visível: desmistificar os sintomas da esclerose múltipla", Público, 2023, https://www.publico.pt/2023/09/24/ciencia/noticia/alem-visivel-desmistificar-sintomas-esclerose-multipla-2064331.
Thesis / Dissertation
  1. Barros, Catarina. "Target S100B to reduce Experimental Autoimmune Encephalomyelitis Pathogenesis". Master, Universidade de Lisboa Instituto de Investigação do Medicamento, 2018.
  2. Barros, Catarina. "Production of recombinant protein to develop polyclonal antibodies". Degree, Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, 2016.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02 Microglia as a crucial player in synaptic pruning in Multiple Sclerosis 54th Meeting of the Portuguse Society of Pharmacology
Portuguese Society of Pharmacology (Portugal)
2023/07 Exploring the impact of microglia and CD8 T cells interplay in Multiple Sclerosis. 14th iMed.ULisboa Postgraduate Students Meeting
iMed.ULisboa Postgraduate Students Commission (ipSC) (Portugal)
2023/05 Microglia and T cells: the dark side of cognitive impairment in Multiple Sclerosis European Neuroscience Conference by Doctoral Students
European Neuroscience Conference by Doctoral Students (Portugal)
2021/02/19 Pentamidine prevents Multiple Sclerosis-like pathogenesis by neutralizing S100B toxic levels 51th Reunião da Sociedade Portuguesa de Farmacologia/39º Reunião de Farmacologia Clínica/20º Reunião de Toxicologia
Faculdade de Farmácia da Universidade de Lisboa (Portugal)
2021/02/19 Improved Frailty Index scale in in vivo model of Multiple Sclerosis: a novel approach to better understand phenotypic alterations in distinct mice-aged. 51a Reunião da Sociedade Portuguesa de Farmacologia, 39a Reunião de Farmacologia Clínica, 20a Reunião de Toxicologia
Faculdade de Farmácia Universidade de Lisboa
2020/09/11 Pentamidine as a new therapeutic strategy against Multiple Sclerosis-like pathology. MS Virtual 2020 - 8th Joint ACTRIMS/ECTRIMS
2019/06/01 S100B has crucial role in neuroinflammation and immune response in the in vivo model of Multiple Sclerosis XVI Meeting of the Portuguese Society for Neuroscience (SPN)
(Lisboa, Portugal)
2019/02/16 Targeting S100B prevents in vivo Multiple Sclerosis-like pathology 5th International Porto Congress of Multiple Sclerosis.
(Porto, Portugal)
2018/11/15 Blockade of S100B prevents MS-associated pathogenesis in EAE model 4th PhD Students Meeting of the Mind-Brain College of the Universidade de Lisboa.
(Lisboa, Portugal)
2018/05/19 S100B blockage prevents ex vivo demyelination and ameliorates EAE clinical score On the way to personalized medicine? New perspectives on treatment and patient monitoring in Multiple Sclerosis.
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/26 - Current 14th iMed.ULisboa Postgraduate Students Meeting (2023/06/26)
Meeting (President of the Organising Committee)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2022/07/04 - 2022/07/05 13th iMed.ULisboa Postgraduate Students Meeting (2022/07/04 - 2022/07/05)
Meeting (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019/07/10 - 2019/07/13 Voluntary in Conference Support in the XIV European Meeting on Glial Cells in Health and Disease. (2019/07/10 - 2019/07/13)
Conference (Member of the Organising Committee)
 Max Delbruck Center for Molcular Medicine, Germany
2019/05/29 - 2019/05/29 Organizing Committee of the IV Symposium of the Portuguese Glial Network "Glia Diversity in Neuromodulation and Neurodegeneration". (2019/05/29 - 2019/05/29)
Symposium (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/03/11 - 2019/03/15 Outreach activities as Brain Awareness Week 2019 (2019/03 - 2019/03) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/10/19 - 2017/11/20 Voluntary in Noite Europeia dos Investigadores (2017/10/19 - 2017/10/20)
Exhibition (Other)
 Ciência Viva, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/02/12 - Current STP Training - Introduction to Cell Sorting
Workshop
The Francis Crick Institute, United Kingdom
2022/11/08 - 2022/11/10 1st ECTRIMS Winter School: Use of MRI in Diagnosis, Management, and Research of Multiple Sclerosis
Workshop
 Use of MRI in Diagnosis, Management, and Research of Multiple Sclerosis
European Committee for Treatment and Research in Multiple Sclerosis, Switzerland
2022/06/20 - 2022/06/22 8th ECTRIMS Summer School 2020 ¿Cognition and behavior in Multiple Sclerosis
Workshop
 Cognition and behavior in Multiple Sclerosis
European Committee for Treatment and Research in Multiple Sclerosis, Switzerland
2021/02/18 - 2021/02/18 FlowJo workshop for data analysis
Workshop
 FlowJo Workshop
Instituto Gulbenkian de Ciência, Portugal
2019/11 - 2019/12 Short Course on Functional Magnetic Resonance Imaging (fMRI)
Workshop
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/12/16 - 2018/12/19 H2020 SynaNet workshop Disrupt>Encode>Consolidate
Workshop
Lancaster University Faculty of Health and Medicine, United Kingdom
2018/06/21 - 2018/06/22 Design & Communication in Science
Workshop
 Design & Communication in Science
Instituto de Medicina Molecular, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022 - Current The iMed.ULisboa Postgraduate Students Commission (ipSC) of the Research Institute for Medicines (iMed.ULisboa) aims to organize, promote, and disseminate scientific activities, fostering training and interaction among students, as well as establishing institutional collaborations to share technical-scientific knowledge.
President / Vice-president
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016/02 - 2016/06 Jornadas Tecnológicas (JORTEC) - “Um Mundo de oportunidades: à descoberta do futuro” This event promote the contact between students, researchers and their future.
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Scientific expedition

Activity description Institution / Organization
2023/07/01 - 2023/07/31 Scientific training period to learn about induced pluripotent stem cells differentiation into neural progenitor cells and 3D-brainspheres Université de Lausanne, Switzerland
2022/05/01 - 2022/06/04 Scientific training period to learn how to analyze RNA sequencing data and to use imaging techniques (functional magnetic resonance imaging). Biodonostia Instituto de Investigación Sanitaria, Spain
Distinctions

Award

2024 SPN Travel Grants for FENS2024
Sociedade Portuguesa de Neurociências, Portugal
2023 DMM Conference Travel Grant
The Company of Biologists Ltd, United Kingdom
2022 EMBO Scientific Exchange Grant

Other distinction

2020 Travel Grant for the 8th ECTRIMS Summer School
European Committee for Treatment and Research in Multiple Sclerosis, Switzerland
2018 Travel Grant for the SynaNet workshop
Horizon 2020, Belgium