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I hold a Bachelor's degree in Biochemistry from FCTUC (University of Coimbra) and a Master's in Cell and Molecular Biology, with a focus on Neurobiology, from FCTUC and CNC (Center for Neuroscience and Cell Biology). During my Bachelor's, I interned in the Group Photonics and Reactivity at the Chemistry Department, University of Coimbra. Subsequently, I received a BIC scholarship in the Group Macromolecules, Colloids, and Photochemistry in the same Department. In my Master's, I did lab rotations in CIBIT (Coimbra Institute for Biomedical Imaging and Translational Research) and in the Group Data-Driven Molecular Design at CNC, where I broadened my expertise by exploring computational techniques, resulting in the production of my thesis dissertation. Currently I'm a Fellow Researcher in the Gene and Stem Cell Therapies for the Brain Group, where I contribute to the design and development of novel AAV capsids for enhanced tropism. In addition to my academic journey, I collaborated with Kosmicare Association and Kykeon Analytics, contributing to drug policy and analysis at events in Portugal. I'm driven by a passion for interdisciplinary research and a commitment to scientific advancement and societal well-being.
Identification

Personal identification

Full name
Guilherme Lopes Gabriel

Citation names

  • Guilherme Lopes-Gabriel

Author identifiers

Ciência ID
1A1D-CC02-FAAC
ORCID iD
0000-0003-4005-2641

Email addresses

  • guilherme.gabriel0199@gmail.com (Professional)
Education
Degree Classification
2024/11/23 - 2028
Ongoing
Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2025/01/20 - 2025/01/31
Attended
PDBEB: Principles and Practices in Drug Development (Curso de mestrado (conclusão do curso de especialização))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2025/01/06 - 2025/01/10
Attended
PDBEB: Synapse Assembly, Function and Plasticity (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/11/25 - 2024/11/29
Attended
PDBEB: Experimental Research Design & Responsible Research Practices (Part I) (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/04/16 - 2024/04/19
Attended
ESGCT 7th Annual Spring School, Hungary (Postgraduate Certificate)
European Society of Gene and Cell Therapy, Hungary
2023/11 - 2024
Ongoing
IBM Data Science (Postgraduate Certificate)
Coursera Inc, United States
2022/07
Concluded
Cell and Molecular Biology (Mestrado)
Major in Specialization in Neurobiology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"In Silico perspective on Psychedelic Studies Characterization of the interaction between small molecules and 5-HT2AR." (THESIS/DISSERTATION)
2017/09 - 2021/01
Concluded
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/01/06 - 2019/01/17
Concluded
II Modular Training in Laboratory Animal Science (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal

CNC.IBILI, Portugal
Affiliation

Others

Category
Host institution
Employer
2024/12/01 - Current PhD Student Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
(...)
2022/11 - 2024/11 Fellow Researcher - Gene and Stem Cell Therapies for the Brain Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/04/30 - 2022/07/15 MSc Student - Data-Driven Molecular Design Group Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/09 - 2019/12 Fellow for Early Scientific Career - Group Macromolecules, Colloids and Photochemistry Universidade de Coimbra Departamento de Química, Portugal
Universidade de Coimbra Departamento de Química, Portugal
2017/12 - 2019/08 Intern - Group Photonics and Reactivity Universidade de Coimbra Departamento de Química, Portugal
Universidade de Coimbra Departamento de Química, Portugal
Projects

Grant

Designation Funders
2023/11/23 - 2024/12/23 Accelerating Research & Development for Advanced Therapies
945473
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Ongoing
2022/11/21 - 2023/11/23 Enhanced AAV vector toolkit for the generation of novel animal models and therapeutic strategies for polyglutamine diseases
2021.05776.BD
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Coimbra Chemistry Center
Scientific Initiation Fellow
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Gabriel, Guilherme L.; Silva, Marta; Batista, Alexandre; Leandro, Kevin; Almeida, Rita; Silva, Ana Carolina; Lopes, M. M.; et al. "Hacking biology: optimizing AAV-based gene delivery for enhanced brain regio-specific targeting". Paper presented in ESGCT 31st Congress, 2024.
  2. Gabriel, Guilherme. "In silico approach on the biochemistry of perception: interaction between DMT and 5-HT2AR and its biased signaling". Paper presented in II Conferencia Psicodélica de Fuerteventura 2023, 2023.
  3. Gabriel, Guilherme. Corresponding author: Gabriel, Guilherme. "In silico approach on the biochemistry of perception: interaction between DMT and 5-HT2AR and its biased signaling". Paper presented in EJIBCE 2021, 2021.
Thesis / Dissertation
  1. "In Silico perspective on Psychedelic Studies Characterization of the interaction between small molecules and 5-HT2AR". Master, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2022.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/09 Hacking biology: optimizing AAV-based gene delivery for enhanced brain region-specific targeting. 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2024/02/09 Generation of lentiviral-base mouse models of spinocerebellar ataxias: where to target? 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2024/02/08 Extracellular vesicles delivery of CRIPR-Cas9 RNPs for therapeutic gene editing in Spinocerebellar Ataxia Type 3 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/07 - 2023/07 Functions of Drug Checking technician (TLC, FTIR, UV-Visible Spectroscopy), in the mobile unit of Associação Kosmicare, at the ZNA Gathering festival in Ponte de Sor, Portugal. In collaboration with Kykeon Analytics.
Festival
2022/08 - 2022/08 Functions of Drug Checking technician (TLC, FTIR, UV-Visible Spectroscopy), in the mobile unit of Associação Kosmicare, at the ZNA Gathering festival in Ponte de Sor, Portugal.
Festival

Association member

Society Organization name Role
2024/03 - Current OPEN Foundation Newsletter article writer; Marketing communications