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Identification

Personal identification

Full name
Rita Henriques Pinto de Barros

Author identifiers

Ciência ID
191D-1EF8-7146
ORCID iD
0000-0002-1667-7329

Telephones

Fax
  • 225570799 (Professional)
Telephone
  • 225570700 (Professional)

Addresses

  • IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto. Rua Júlio Amaral de Carvalho, 45 , 4200-135, Porto, Porto, Portugal (Professional)
Education
Degree Classification
2010/12/16
Concluded
 Doutoramento em Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Identification of signalling pathways involved in CDX2 regulation in metaplastic lesions" (THESIS/DISSERTATION)
 Aprovado, com distinção, por unanimidade
2005
Concluded
 Bioquímica - Ramo de Especialização em Bioquímica Aplicada (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Analysis of a multigene domain frequently targeted in MLV-induced T cell lymphomas in mice" (THESIS/DISSERTATION)
 17 valores
Affiliation

Positions / Appointments

Category
Host institution 		Employer
2018/09/01 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Centro Hospitalar Universitário de S. João, Portugal

Others

Category
Host institution 		Employer
2018/09/01 - 2024/08/31 Junior Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011/07/01 - 2017/11/30 Post-Doc Fellow Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011/02/01 - 2011/05/31 Visiting Post-Doc Researcher Icahn School of Medicine at Mount Sinai Black Family Stem Cell Institute, United States
2007/09/01 - 2010/12/31 Free Assistant Universidade do Porto Faculdade de Medicina, Portugal
2007/01/01 - 2010/12/16 PhD Student Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/10/01 - 2006/12/31 BI Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Contract

Designation Funders
2023/01/02 - 2024/07/01 O papel do exportador de heme FLVCR1 no carcinoma hepatocelular
2022.03222.PTDC
10.54499/2022.03222.PTDC
Centro Hospitalar Universitário de São João, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2023/06/30 CeLac and European consortium for a personalized medicine approach to Gastric Cancer
825832
10.3030/825832
Integration into Research Grant Fellow
European Commission
Concluded
2018/07/01 - 2021/12/31 Reconstructing the Program of Cancer Stem Cells
PTDC/MED-ONC/29017/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/06/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/07/01 - 2018/08/31 MOUSE MODELS OF INTESTINAL METAPLASIA - EXPLORING PATHWAYS FROM THE TGF-BETA SUPERFAMILY
SFRH/BPD/68276/2010
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/07/01 - 2011/09/29 CDX2 autoregulation in the reversibility/irreversibility of gastric intestinal metaplasia
PTDC/SAU-OBD/64490/2006
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2010/12/31 IDENTIFICATION OF SIGNALING PATHWAYS INVOLVED IN THE REGULATION OF CDX2 IN METAPLASTIC LESIONS
SFRH/BD/29622/2006
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Ribeirinho, Sara; Mesquita, Patricia; Marques, Cristiana; Barros, Rita; Amaral, Ana Luísa; Azevedo, Diana; Freire, Ana Filipa; David, Leonor; Almeida, Raquel. "SOX2 predicts stage II CRC patients response to adjuvant chemotherapy". Paper presented in Third international congress of the Portuguese Association of Cancer Research (ASPIC) that took place in 10th and 11st of May at the Gulbenkian Foundation, Lisbon, Portugal,, 2018.
    10.1158/1538-7445.am2015-5274
  2. Ribeirinho, Sara; Mesquita, Patricia; Freire, Ana Filipa; Pádua, Diana; Coelho, Ricardo; Marques, Cristiana; Barros, Rita; et al. "SOX2 as a predictive biomarker of resistance to therapy in stage II CRC patients". Paper presented in Annual meeting of the Instituto de Investigação e Inovação em Saúde that took place 29th and 30th of November 2018 at the Axis Vermar Conference & Beach Hotel in Póvoa de Varzim, Portugal, 2018.
  3. Pádua, Diana; Barros, Rita; Almeida, Raquel. "Isolation and characterization of gastric cancer stem cells based on SOX2/OCT4 activity". Paper presented in IJUP 10ª edição – Encontro de Investigação Jovem Universidade do Porto, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal, 2017.
  4. Ribeiro, Ana; de Oliveira, JT; Gomes, C; Barros, Rita; de Matos, Augusto J.; Reis, CA; Gärtner, Fátima. "Microenvironment-dependent regulation of galectin-3 in mammary tumours". Paper presented in GLYCO-T-9º International Symposium on Glycosyltransferases, 2014.
    10.1158/2326-6074.tumimm17-b67
  5. Ribeiro, Ana; de Oliveira, JT; Gomes, C; Barros, Rita; de Matos, Augusto J.; Reis, CA; Rutteman, Gerard R.; Gärtner, Fátima. "Galectin-3 is part of the cell response to stressful conditions in canine mammary tumors". Paper presented in 1st ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2014.
Journal article
  1. Amaro, Helena M.; Barros, Rita; Tavares, Tânia; Almeida, Raquel; Pinto, Isabel Sousa; Malcata, Francisco Xavier; Guedes, Ana Catarina. "Gloeothece sp.—Exploiting a New Source of Antioxidant, Anti-Inflammatory, and Antitumor Agents". Marine Drugs 19 11 (2021): 623. http://dx.doi.org/10.3390/md19110623.
    10.3390/md19110623
  2. Ribeirinho-Soares, Sara; Pádua, Diana; Amaral, Ana Luísa; Valentini, Elvia; Azevedo, Daniela; Marques, Cristiana; Barros, Rita; et al. "Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients". BMC Cancer 21 1 (2021): http://dx.doi.org/10.1186/s12885-021-08070-6.
    10.1186/s12885-021-08070-6
  3. Osório, Hugo; Silva, Cátia; Ferreira, Marta; Gullo, Irene; Máximo, Valdemar; Barros, Rita; Mendonça, Fernando; Oliveira, Carla; Carneiro, Fátima. "Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus". Journal of Clinical Medicine 10 3 (2021): 407. http://dx.doi.org/10.3390/jcm10030407.
    10.3390/jcm10030407
  4. Barros, Rita. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers (2020): http://dx.doi.org/10.3390/cancers12020495.
    10.3390/cancers12020495
  5. Barros, Rita. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Cell Communication and Signaling (2019): http://dx.doi.org/10.1186/s12964-019-0465-9.
    10.1186/s12964-019-0465-9
  6. Barros, Rita. "Expression and Clinical Relevance of SOX9 in Gastric Cancer". Disease Markers (2019): http://dx.doi.org/10.1155/2019/8267021.
    10.1155/2019/8267021
  7. Barros, Rita. "Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019". (2019): http://dx.doi.org/10.1055/a-0859-1883.
    10.1055/a-0859-1883
  8. Barros, Rita. "Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer". (2018): http://dx.doi.org/10.1002/1878-0261.12347.
    10.1002/1878-0261.12347
  9. Barros, Rita. "Mechanisms of regulation of normal and metaplastic intestinal differentiation". (2018): http://doi.org/10.14670/HH-11-938.
    10.14670/HH-11-938
  10. Barros, Rita. "Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?". (2017): http://dx.doi.org/10.1177/1066896916672332.
    10.1177/1066896916672332
  11. Barros, Rita. "Serum Galectin-3 Levels in Dogs with Metastatic and Non-metastatic Mammary Tumors.". In vivo (Athens, Greece) (2016):
  12. Barros, Rita. "Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa". (2016): http://dx.doi.org/10.1155/2016/1532791.
    10.1155/2016/1532791
  13. de Oliveira, JT; Santos, AL; Barros, Rita; Ribeiro, Claudia; Gomes, Catarina; de Matos, Augusto J.; Reis, CA; Gartner, Fátima. "Characterization of Sialidases Neu1, Neu2, and Neu4 in a Canine Model of Breast Cancer". Glycobiology Insights 6 (2016): 11-19. http://dx.doi.org/10.4137/gbi.s30034.
    10.4137/gbi.s30034
  14. Barros, Rita. "Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis". (2015): http://dx.doi.org/10.1371/journal.pone.0134458.
    10.1371/journal.pone.0134458
  15. de Oliveira, Joana T.; Santos, Ana L.; Gomes, Catarina; Barros, Rita; Ribeiro, Cláudia; Mendes, Nuno; de Matos, Augusto J.; et al. "Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate Induces Canine Mammary Cancer Cell Aggressiveness". PLOS ONE 10 4 (2015): e0121590. http://dx.doi.org/10.1371/journal.pone.0121590.
    10.1371/journal.pone.0121590
  16. Pinto, R.a b c , Barros, R.a b , Pereira-Castro, I.b h , Mesquita, P.d , Da Costa, L.T.e , Bennett, E.P.f , Almeida, R.a. "CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia". Laboratory Investigation 95 7 (2015): 718-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933060097&partnerID=40&md5=979c15e28c608864bfbc6fdd1a0994d8.
    10.1038/labinvest.2015.52
  17. Camilo, Vânia; Garrido, Mónica; Valente, Pedro; Ricardo, Sara; Amaral, Ana Luísa; Barros, Rita; Chaves, Paula; et al. "Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2". Histopathology 66 3 (2014): 343-350. http://dx.doi.org/10.1111/his.12544.
    10.1111/his.12544
  18. Camilo, Vania; Barros, Rita; Celestino, Ricardo; Castro, Patrcia; Vieira, Joana; Teixeira, Manuel R.; Carneiro, Fatima; et al. "Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome". Bmc Cancer 14 (2014):
    10.1186/1471-2407-14-753
  19. Bastos, Joana; Peleteiro, Bárbara; Barros, Rita; Alves, Luís; Severo, Milton; de Fátima Pina, Maria; Pinto, Hugo; et al. "Sociodemographic Determinants of Prevalence and Incidence ofHelicobacter pyloriInfection in Portuguese Adults". Helicobacter 18 6 (2013): 413-422. http://dx.doi.org/10.1111/hel.12061.
    10.1111/hel.12061
  20. Pereira, Bruno; Sousa, Sofia; Barros, Rita; Carreto, Laura; Oliveira, Patrícia; Oliveira, Carla; Chartier, Nicolas T.; et al. "CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness". Nucleic Acids Research 41 7 (2013): 3986-3999. http://dx.doi.org/10.1093/nar/gkt087.
    10.1093/nar/gkt087
  21. Amaro, H.M.a b , Barros, R.c , Guedes, A.C.a , Sousa-Pinto, I.a d , Malcata, F.X.a e. "Microalgal compounds modulate carcinogenesis in the gastrointestinal tract". Trends in Biotechnology 31 2 (2013): 92-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872788447&partnerID=40&md5=b7565d09732d6b810211ada99f150625.
    10.1016/j.tibtech.2012.11.004
  22. Clavel, Carlos; Grisanti, Laura; Zemla, Roland; Rezza, Amelie; Barros, Rita; Sennett, Rachel; Mazloom, Amin Reza; et al. "Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors". Developmental Cell 23 5 (2012): 981-994. http://dx.doi.org/10.1016/j.devcel.2012.10.013.
    10.1016/j.devcel.2012.10.013
  23. Peleteiro, Bárbara; Barros, Rita; Carrilho, Carla; Artiaga, Jeronimo; Cunha, Lina; Modcoicar, Prassad; Ferreira, Rui; et al. "Determinants of gastric CDX2 expression". European Journal of Cancer Prevention 21 6 (2012): 532-540. http://dx.doi.org/10.1097/cej.0b013e3283523480.
    10.1097/cej.0b013e3283523480
  24. Camilo, V.; Barros, R.; Sousa, S.; Magalhaes, A. M.; Lopes, T.; Mario Santos, A.; Pereira, T.; et al. "Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells". Carcinogenesis 33 10 (2012): 1985-1992. http://dx.doi.org/10.1093/carcin/bgs233.
    10.1093/carcin/bgs233
  25. Barros, R.a , Freund, J.-N.b , David, L.a c , Almeida, R.a c. "Gastric intestinal metaplasia revisited: Function and regulation of CDX2". Trends in Molecular Medicine 18 9 (2012): 555-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865606611&partnerID=40&md5=c44c5fd52e36729d1287239b7e5145b2.
    10.1016/j.molmed.2012.07.006
  26. Peleteiro, B.a c , Lunet, N.a c , Wen, X.b , Afonso, L.P.d , Mendes, N.e , Barros, R.e , Carneiro, F.b e e , Almeida, R. "Association between environmental factors and CDX2 expression in gastric cancer patients". European Journal of Cancer Prevention 21 5 (2012): 423-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864358456&partnerID=40&md5=12fd68cb01506c960e20d8df2af3c21d.
    10.1097/CEJ.0b013e32834ef1aa
  27. Peleteiro, B.a b , Cavaleiro-Pinto, M.a , Barros, R.c , Barros, H.a b , Lunet, N.a b. "Is cardia cancer aetiologically different from distal stomach cancer?". European Journal of Cancer Prevention 20 2 (2011): 96-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551517275&partnerID=40&md5=914afc3cf42ad39b08eb7fd1d19a5b40.
    10.1097/CEJ.0b013e3283429e77
  28. Barros, R.a , Da Costa, L.T.a b , Pinto-de-Sousa, J.c d , Duluc, I.e , Freund, J.-N.e , David, L.a d , Almeida, R.a d. "CDX2 autoregulation in human intestinal metaplasia of the stomach: Impact on the stability of the phenotype". Gut 60 3 (2011): 290-298. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851514659&partnerID=40&md5=446e9f88ef676af0a679e57adba9a094.
    10.1136/gut.2010.222323
  29. Peleteiro, B.a b f , Lunet, N.a b , Barros, R.c , La Vecchia, C.d e , Barros, H.a b. "Factors contributing to the underestimation of Helicobacter pylori-associated gastric cancer risk in a high-prevalence population". Cancer Causes and Control 21 8 (2010): 1257-1264. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955713569&partnerID=40&md5=2d80fe27b0c934a30e16f5e0ac05fb60.
    10.1007/s10552-010-9553-2
  30. Barros, R.a , Peleteiro, B.b c , Almeida, R.a d , Figueiredo, C.a d , Barros, H.b c , David, L.a d , Lunet, N.b c. "Relevance of high virulence Helicobacter pylori strains and futility of CDX2 expression for predicting intestinal metaplasia after eradication of infection". Scandinavian Journal of Gastroenterology 45 7-8 (2010): 828-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955694652&partnerID=40&md5=2d4825eef755f5d42620176bd8563896.
    10.3109/00365521003770269
  31. Barros, R.a b , Camilo, V.a b , Pereira, B.a b , Freund, J.-N.c , David, L.a b , Almeida, R.a b. "Pathophysiology of intestinal metaplasia of the stomach: Emphasis on CDX2 regulation". Biochemical Society Transactions 38 2 (2010): 358-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953279584&partnerID=40&md5=ee2d5cd5eb100703f515113f2bbefa29.
    10.1042/BST0380358
  32. Barros, R.a , Marcos, N.a , Reis, C.A.a b , De Luca, A.b , David, L.c , Almeida, R.a d. "CDX2 expression is induced by Helicobacter pylori in AGS cells". Scandinavian Journal of Gastroenterology 44 1 (2009): 124-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149099117&partnerID=40&md5=a5abde5751be4abe8cab489b7ba88260.
    10.1080/00365520802530846
  33. Barros, R.a , Mendes, N.a , Howe, J.R.e , Reis, C.A.a b , De Bolos, C.c , Carneiro, F.a b d , David, L.a b , Almeida, R.. "Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4". Histochemistry and Cell Biology 131 6 (2009): 765-772. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349211762&partnerID=40&md5=d01b2e8f6ff027d75336b9d22265e187.
    10.1007/s00418-009-0579-z
  34. Barros, R; Pereira, B; Duluc, I; Azevedo, M; Mendes, N; Camilo, V; Jacobs, RJ; et al. "Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines". The Journal of Pathology 215 4 (2008): 411-420. http://dx.doi.org/10.1002/path.2369.
    10.1002/path.2369
Preprint
  1. Costa, Ana Filipa; Senra, Emanuel; Campos, Diana; Faria-Ramos, Isabel; Santos-Ferreira, Liliana; Lamas, Sofia; Gomes, Joana; et al. Corresponding author: Gomes, Catarina. "Monensin as potential drug for treatment of SLeX-positive tumors". 2024. http://dx.doi.org/10.1101/2024.03.11.24304048.
    10.1101/2024.03.11.24304048
Distinctions

Award

2009 Biochemical Society poster prize at the "Barrett's Metaplasia" Meeting
Biochemical Society, United Kingdom
2006 Prémio Eng. António de Almeida
Fundação Engenheiro António de Almeida, Portugal
2004 Prémio Fernando Serrão
Universidade do Porto Faculdade de Ciências, Portugal